56 results about "Aspartame" patented technology

The invention discloses a bacterial strain for degrading aspartame, a bacterial-algae symbiotic system and application of the bacterial strain and the bacterial-algae symbiotic system, the bacterial strain is corn sphingomonas zeae NCU J1, and the preservation number of the bacterial strain is CCTCC (China Center for Type Culture Collection) NO: M 20251462. And an algal-bacterial symbiotic system is constructed by adopting an oriented symbiotic combination of the corn sphingomonas NCU J1 and the chlorella sp. The corn sphingomonas NCU J1 can metabolize an artificial sweetening agent aspartame and degradation products thereof, metabolism complementation can be achieved through an algal-bacterial symbiotic interface, and bacteria preferentially promote aspartame to be subjected to photohydrolysis to generate degradation products such as diketopiperazine derivatives. The microalgae synchronously start isomerism enzymatic reaction to convert degradation products such as diketopiperazine derivatives into low-toxicity products, the risk of secondary pollution is reduced by 40% or above compared with that of a traditional physical and chemical method, 150 mg / L aspartame can be efficiently degraded within 2 days, generation of derivatives of aspartame can be greatly reduced, secondary pollution is reduced, and the method is suitable for industrial production. And the method has a good application prospect in the aspect of rapidly treating aspartame-containing wastewater.

The invention discloses a preparation method of a high-performance peelable asparagus polyurea resin coating, and the high-performance peelable asparagus polyurea resin coating is prepared from the following raw materials in parts by weight: 40-50 parts of asparagus polyurea resin, 30-35 parts of an isocyanate curing agent, 3-6 parts of epoxy resin, 15-20 parts of a diluent, 0.2-0.8 part of a flatting agent and 0.2-0.8 part of a defoaming agent. Comprising the following steps: step 1, mixing the epoxy resin with a diluent to obtain a system 1; step 2, uniformly mixing and stirring asparagus polyurea resin, the system 1 and a diluent of the system 1 to obtain a system 2; step 3, adding the flatting agent and the defoaming agent into the system 2 obtained in the step 2 according to the proportion, and uniformly mixing and stirring to obtain a system 3; step 4, mixing an isocyanate curing agent with a diluent to obtain a system 4; and step 5, adding the system 4 into the system 3, and uniformly mixing and stirring to obtain the coating. The preparation method can be used for preparing the asparagus polyurea resin coating with high mechanical strength, weather resistance, low VOC (volatile organic compound) emission and controllable stripping performance.

The application belongs to the technical field of drug dissolution and dispersion, and particularly relates to a bunazosin water-based solution preparation and a preparation method. The bunazosin water-based solution preparation provided by the application comprises the following components: bunazosin, gamma-cyclodextrin, lecithin, polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, aspartame and water. The above components are mixed to be homogeneous to prepare an oral solution which is uniform, clear and can be stored for a long time. The scheme of the application further enriches the dosage form of bunazosin, improves the convenience of taking bunazosin, and is expected to help improve the oral bioavailability and absorption efficiency of bunazosin. The scheme of the application also provides a reference direction for the mechanism research on the dissolution and dispersion behavior of the insoluble bunazosin macromolecule in a water medium.

Disclosed herein are formulations (including sweet proteins and rare sugars) for improving the sweetness of low glycemic index rare sugars without altering the texture and flavor of the rare sugars and methods for improving the sweetness of rare sugars. More specifically, the present invention discloses methods for improving the sweetness of rare sugars without altering the sweetness profile, texture and flavor of the primary sugars. The invention also discloses the addition of Brazitame protein with liquid rare sugars at different temperatures during the synthesis of the rare sugars, before crystallization or before or after caramelization of the rare sugars, to increase sweetness. The Brazilian sweet protein increases the sweetness of rare sugars, but is not limited to D-psicose, D-tagatose, D-allose, isomaltulose, trehalose, sorbose, pinose, leucobiose and the like. The invention also provides for the evaluation of non-nutritional sweeteners (such as aspartame, acesulfame, sodium cyclamate, neotame, saccharin, sucralose, stevioside, etc.), as each has a limitation of taste quality if used with rare sugars. However, the use of Brazilian sweet protein does not alter the flavor and texture of rare sugars, and the taste profile matches sucrose.

This invention discloses an aspartame production mother liquor recovery and treatment device and process, including a main frame and a top cover. Diversion pipes are installed on both sides of the main frame, nozzles are installed on both sides of the inner wall of the main frame, the top cover is installed at the top of the main frame, and a drain port is provided at the bottom of one side of the main frame. A positioning groove is opened at the bottom of the outer wall of the collection bucket, and a cleaning structure is provided at the bottom of the rotating disk. This invention, by providing an auxiliary structure, includes a socket at the top of the rotating disk for inserting the collection bucket. Under the elastic force of a return spring, the positioning block slides along the inside of the groove towards the collection bucket and engages with the inside of the positioning groove, thus ensuring stable installation of the collection bucket. Furthermore, when removing the collection bucket, simply reverse the lever to remove the positioning block from the positioning groove, and the collection bucket can be pulled out upwards, thereby improving the recovery efficiency of the device.

The invention relates to a sweetening composition comprising a naturally sweet carbohydrate, a stevia compound, rubusoside, and tannin, wherein component d) is present in an amount on the scale of 1 mg / l to 400 mg / l; the invention also relates to a sweetening composition comprising a naturally sweet carbohydrate, a stevia compound, rubusoside, tannin, and oak extract or pomegranate extract; the invention further relates to a sweetening composition comprising acesulfame or aspartame, sucralose, a stevia compound, saccharin or cyclamate, neohesperidin, and tannin in an amount on the scale of 1 mg / l to 400 mg / l; furthermore, the invention relates to a sweetening composition comprising a) 0.1 to 50 g / l of a naturally sweet-tasting carbohydrate, b) 40 to 120 g / l of a naturally sweet-tasting carbohydrate other than a), and c) 30 to 300 mg / l of rubusoside; and, the invention relates to the use of said sweetening compositions for sweetening and preparing beverages.

The present invention relates to a spinosad cockroach bait and a preparation method thereof, comprising the following raw materials in percentage by content: 2% of spinosad; 0.1-0.3% of saccharide; 1-15% of taste additive; 0.1-0.5% of essence; and the balance of filler. The saccharide is aspartame. The taste additive includes one or more of talcum powder and mono- and diglycerides of fatty acids. The filler is roasted soybean cake powder. The invention is green, environment-friendly and degradable, not easy to absorb moisture and cake, and can induce cockroaches to eat.

The invention relates to a traditional Chinese medicine preparation for treating gastritis and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 40-50 parts of a traditional Chinese medicine composition, 10-15 parts of a sustained release agent, 25-32 parts of a filling agent and 3-8 parts of a flavoring agent, the slow release agent is modified carboxymethyl konjac glucomannan; the filling agent is cordyceps militaris polysaccharide and lactose; the flavoring agent is aspartame or sucralose. The sustained release agent is neohesperidin dihydrochalcone modified carboxymethyl konjac glucomannan, neohesperidin dihydrochalcone has the effect of inhibiting gastric acid secretion, and neohesperidin dihydrochalcone and the traditional Chinese medicine ingredient cuttlebone can synergistically play a role in preparing acid and jointly play a role in protecting gastric mucosa. Meanwhile, the cordyceps militaris polysaccharide has polysaccharide generality of thickening and stable film forming, and forms a compact network structure together with the modified carboxymethyl konjac glucomannan, and the obtained traditional Chinese medicine preparation has a good slow release effect.

The invention discloses a preparation method for prolonging the validity period of erythromycin ethylsuccinate orally disintegrating tablets. The preparation method comprises the following steps: sequentially putting low-substituted hydroxypropyl cellulose, microcrystalline cellulose, aspartame, carboxymethyl starch sodium and polyvinylpolypyrrolidone into a wet granulation mixer, covering with a cover, starting equipment, carrying out low-speed dry mixing for 3 minutes, slowly adding low-concentration hydroxypropyl methylcellulose slurry from a feed port of a pot cover, and carrying out low-speed wet mixing for 3 minutes; stopping the machine, opening the cover, scraping powder on the inner surface of the pot cover and the periphery of the inner side of the pot by using a clean scraper, adding erythromycin ethylsuccinate raw materials, covering the cover, starting equipment, carrying out low-speed wet mixing for 3 minutes, and carrying out high-speed wet mixing for 2 minutes. By improving the medicine production process, the stability and durability of the medicine are improved, so that the validity period of the medicine is prolonged, and meanwhile, the effectiveness and safety of the medicine can still be kept within the prolonged validity period.

The invention discloses a preparation method and application of metal organic framework immobilized ligase. The immobilized enzyme is prepared by encapsulating a high-performance ligase mutant Q186G / S328A with an amino acid sequence as shown in SEQ ID NO: 2 into a ZIF-8 framework in situ. The immobilized enzyme has high catalytic activity and high alpha-regioselectivity of the mutant and excellent stability brought by ZIF-8 encapsulation. When being used for catalyzing condensation of L-aspartic acid-alpha, beta-dimethyl ester and L-phenylalanine to prepare an aspartame key intermediate alpha-AMP, the alpha-AMP has the conversion rate, selectivity and operation stability which are superior to those of free enzyme, and can be recycled for multiple times while the activity is kept good. The invention provides a brand-new enzyme catalysis process for green, efficient, economical and industrial synthesis of aspartame.

The present invention relates to a confectionery containing psicose. Specifically disclosed is a sugar-free confectionery composition which is a jelly confectionery wherein the confectionery comprises: from 1% to 50% by weight of psicose; and from 1% to 50% of a polyol incremental sweetener in combination with a high-potency sweetener wherein the polyol incremental sweetener is selected from the group consisting of sorbitol, maltitol, isomaltitol, mannitol, xylitol, erythritol, and lactitol, and the high-potency sweetener is selected from the group consisting of kiwifruit protein, aspartame, acesulfame K, saccharin sodium, glycyrrhizin, Alisan, cyclohexylsulfamate, stevioside, dihydrochalcone, stevioside, stevioside, glycosylated stevioside, and Momordica grosvenori, and wherein the confectionery composition has a moisture content of from 15% to 20%, and wherein the sweetener is selected from the group consisting of ketoside, aspartame, acesulfame K, saccharin sodium, glycyrrhizin, Alisan, cyclohexylsulfamate, stevioside, dihydrochalcone, stevioside, glycosylated stevioside, and Momordica grosvenori; a method of making the sugar-free confectionery composition is also disclosed. The present invention provides a low calorie, low laxative confection comprising psicose with acceptable texture, stability, clarity, flavor delivery, and shelf life.

This invention relates to the field of detection, specifically to a method for the simultaneous determination of four flavoring agents in montmorillonite powder using high-performance liquid chromatography (HPLC). The method detects four flavoring agents in montmorillonite powder: sodium saccharin, aspartame, vanillin, and steviol glycoside. All four flavoring agents are separated from the baseline with satisfactory resolution, and there is no interference from excipients. The limits of detection (LODs) for sodium saccharin, aspartame, vanillin, and steviol glycoside are 4.66, 7.87, 7.81, and 8.51 ng / mL, respectively; the limits of quantitation (LOQs) are 13.98, 26.23, 26.02, and 25.52 ng / mL, respectively. The method developed in this invention exhibits high repeatability and stability, and can be used for the identification and content determination of flavoring agents in montmorillonite powder, providing a reference for the quality control of flavoring agents in montmorillonite powder.

The application discloses a Ce SA-MXene composite material and a preparation method and application thereof, the Ce SA-MXene composite material is formed by anchoring single-atom cerium on MXene, and the anchoring amount of the single-atom cerium accounts for 1-50 wt% of the total composite material; the preparation method comprises the following steps: adding cerium salt into a MXene suspension, fully mixing, filtering, washing and drying the obtained mixed solution, and then performing step-by-step calcination treatment, and the Ce SA-MXene composite material is obtained after the end of the step-by-step calcination treatment. The Ce SA-MXene composite material synthesized by the application has a large specific surface area, the metal cerium is dispersed in the form of atoms, the metal active sites are fully exposed, the reactivity and stability of the Ce SA-MXene composite material are enhanced by increasing the active sites, the Ce SA-MXene composite material is applied to the field of water pollution as a catalyst, can efficiently adsorb pollutants, such as artificial sweetener aspartame, can also realize recycling of the metal cerium, has the advantages of high catalytic efficiency, high use value, easy recycling and the like, and has a wide application prospect.

The invention relates to an electrolyte of a low-temperature water-based zinc ion battery, which is characterized in that an additive is formed by compounding sodium dodecyl benzene sulfonate, carboxymethyl cellulose and aspartame, and the ionic conductivity of the electrolyte at-30 DEG C is not less than 5 mS / cm; the zinc salt is one or more of zinc chloride, zinc nitrate, zinc perchlorate, zinc sulfate, zinc trifluoromethanesulfonate, zinc acetate, zinc citrate, zinc gluconate and zinc oxalate; the additives are sodium dodecyl benzene sulfonate, carboxymethyl cellulose and aspartame; the problems that an existing aqueous battery electrolyte additive is high in cost, large in environmental pollution and the like are solved. By optimizing the electrolyte formula, the working performance of the aqueous zinc ion battery under the low-temperature condition is improved.

The invention provides a modified radix asparagi polyurea coating composition, and relates to the technical field of radix asparagi polyurea. In the component A of the modified aspartic polyurea coating composition disclosed by the invention, the first aspartic ester resin containing a plurality of secondary amino groups and alkoxy silicon groups is used as matrix resin or one of the matrix resin, so that the modified aspartic polyurea coating composition has relatively good adhesive force on an inorganic base material, especially a metal base material; and the adhesive force, the anti-corrosion effect and the like of the asparagine polyurea coating on an inorganic base material, especially a metal base material are optimized.

The purpose of the present invention is to provide a novel crystal complex of nicotinamide mononucleotide, which is stable and highly safe. The present invention relates to a crystalline complex of a nicotinamide mononucleotide and a phenylalanine compound, the phenylalanine compound being L-phenylalanine and having peaks at diffraction angles (2 [theta]) of 19.7 + / -0.2 DEG, 26.4 + / -0.2 DEG, and 32.8 + / -0.2 DEG in a powder X-ray diffraction pattern measured using Cu-K [alpha] rays as an X-ray source. Alternatively, the phenylalanine-based compound is aspartame and has peaks at diffraction angles (2 [theta]) of 7.0 + / -0.2 DEG, 10.7 + / -0.2 DEG, 14.4 + / -0.2 DEG, and 29.1 + / -0.2 DEG in a powder X-ray diffraction pattern measured using a Cu-K [alpha] ray as an X-ray source.

A novel crystalline complex of nicotinamide mononucleotide that is stable and highly safe is provided. The crystalline complex contains nicotinamide mononucleotide and a phenylalanine-based compound. The crystalline complex has L-phenylalanine or aspartame as the phenylalanine-based compound. The crystalline complex having L-phenylalanine as the phenylalanine-based compound has peaks at diffraction angles (2θ) of 19.7±0.2°, 26.4±0.2°, and 32.8±0.2° in a diffraction pattern of powder X-ray diffraction measured with a Cu-Kα ray as an X-ray source. The crystalline complex having aspartame as the phenylalanine-based compound has peaks at diffraction angles (2θ) of 7.0±0.2°, 10.7±0.2°, 14.4±0.2°, and 29.1±0.2° in a diffraction pattern of powder X-ray diffraction measured with a Cu-Kα ray as an X-ray source.

The invention provides a cefditoren pivoxil particle and a preparation method thereof, the particle comprises a cefditoren pivoxil amorphous substance, hydroxypropyl methylcellulose, croscarmellose sodium, sucrose, aspartame, sucrose fatty acid ester, a coloring agent, sodium chloride and fruity essence, and the particle is obtained through a fluidized bed rotational flow side spraying granulation coating technology. The cefditoren pivoxil granules are round, controllable in particle size distribution range, fast in dissolution, good in stability, good in taste, good in in-vivo bioavailability and suitable for clinical use of children and old patients.

The present invention discloses a low-browning chitosan oligosaccharide tablet and a preparation method thereof, and belongs to the field of drug preparation technology. The low-browning chitosan oligosaccharide tablet of the present invention contains the following components by mass: 65-80 parts of chitosan oligosaccharide, 0-30 parts of D-mannitol, 5-12 parts of microcrystalline cellulose, 0.5-2 parts of sodium carboxymethyl starch, 2-5 parts of pyrroloquinoline quinone disodium salt, 0.01-0.02 parts of sodium metabisulfite, 0.5-2 parts of magnesium stearate, 0.1-3 parts of citric acid, and 0.01-0.5 parts of aspartame. The chitosan oligosaccharide tablet prepared by the above-mentioned components of the present invention has good adhesion, a smooth surface, no edge knocking or fragmentation, light product color, good stability, and almost no browning.

The utility model discloses a kind of neutralization reaction devices for aspartame purification, including reaction component, the upper portion of reaction component is equipped with make-up component, and make-up component is close to the side of reaction component middle axis and is provided with protective box, the inside of protective box is installed with first rotating component, and the rear end of first rotating component is connected with transmission component, first rotating component includes rotating big dish, first rotating shaft and first bearing, and the front end of rotating big dish is connected with first rotating shaft, the outside of first rotating shaft is connected with first bearing. Compared with the existing ordinary neutralization reaction device, the equipment can adjust transmission ratio, the proportion of material discharging is adjusted by the change of transmission ratio, so that the proportion of material adding is more accurate, the equipment can make material better spread by stirring structure, so that the mixing of material is more uniform.

The invention relates to the technical field of aspartame production equipment, in particular to a novel cooling device in aspartame production, which comprises a production tank, the production tank comprises a tank body and a tank cover, the tank cover is fixedly mounted on the upper end face of the tank body, an equipment hanging bracket is fixedly mounted in the tank body, and the equipment hanging bracket is fixedly mounted on the lower end face of the tank body. A center shell is fixedly installed below the equipment hanging bracket, a circulating cooling pipe set is arranged on the outer side face of the center shell, the two ends of the circulating cooling pipe set are fixedly installed in the center shell, and a stirring rod set is further installed in the middle of the center shell. The production tank is designed to be of a structure that the tank body and the tank cover are matched with each other, the center shell is stably and fixedly installed by installing the equipment hanging bracket in the tank body, then the circulating cooling pipe set can be stably installed through the center shell, and the circulating cooling pipe set is combined with the stirring structure; in the processing process, normal stirring and use can be achieved through the stirring assembly, and meanwhile the cooling efficiency can be effectively improved through the stirring mode.

The invention belongs to the technical field of bacteriostatic preparations, and particularly relates to an antiviral and bacteriostatic composition as well as a preparation method and application thereof. The antiviral and bacteriostatic composition is prepared from aprotinin, benzalkonium chloride, zinc gluconate, a plant extract, a flavoring agent and a solvent. The antibacterial rates of the antiviral and antibacterial composition to escherichia coli, staphylococcus aureus, candida albicans and pseudomonas aeruginosa are all higher than 99%, and the antiviral and antibacterial composition has a relatively strong antibacterial effect; the antiviral and bacteriostatic composition disclosed by the invention has a relatively strong inhibition effect on H3N2 and H1N1 influenza viruses; meanwhile, the safety is high, and if the eye drops accidentally enter the eyes, the eye drops have no irritation to the eyes and do not generate side effects of damaging the eyes. According to the antiviral and bacteriostatic composition, the peppermint essence and the aspartame in a specific ratio are combined as the flavoring agent, so that the antiviral and bacteriostatic composition is free of bitter and astringent feeling when being sprayed into the oral cavity and after being sprayed into the oral cavity, and also has proper sweetness.

The invention belongs to the technical field of chemicals, and particularly provides a preparation method of calcium carbonate dimeticone chewable tablets, which comprises the following steps: 1) mixing dimeticone and superfine silica powder, adding calcium carbonate, uniformly mixing, adding aspartame, essence, mannitol, corn starch and hydroxy propyl cellulose, sieving, and uniformly mixing to obtain a base material; (2) adding ethylene glycol chitosan and guar gum into a buffer solution, uniformly stirring, adding a galactose oxidase solution and a catalase solution, reacting at room temperature, adding compound polysaccharide, and continuously uniformly mixing to obtain slurry; and 3) adding the slurry and magnesium stearate into the base material, uniformly mixing to prepare a soft material, and then granulating and tabletting to obtain the calcium carbonate dimeticone chewable tablet. The calcium carbonate dimeticone chewable tablet prepared by the invention has the advantages of stable drug release, long drug effect duration and small adverse reaction.

The invention discloses bubble candies capable of supporting vision health and a preparation method of the bubble candies, and belongs to the technical field of food processing. The bubble candy comprises vitamin C, sodium ascorbate, lutein ester, zeaxanthin, astaxanthin, anthocyanin, beta carotene, semen cassiae, chrysanthemum, DL-malic acid, citric acid, sodium bicarbonate, sorbitol, xylitol, sucralose, stevioside, aspartame, passion fruit powder essence, magnesium stearate, sunset yellow aluminum lake, allura red aluminum lake and lemon yellow aluminum lake. The preparation method comprises the following steps: (1) weighing; (2) mixing; (3) tabletting; and (4) packaging. Starting from the goal of protecting eyesight health, vitamins, minerals and functional plant extract raw materials are taken as main materials, a carrier sorbitol with good compressibility, citric acid capable of improving bubble feeling, sodium bicarbonate and the like are taken as auxiliary materials, and according to a high-quality production process, the product dosage form is designed into the bubble tablet candy, so that the bubble tablet candy has better stability, and is suitable for popularization and application. The carrying is convenient.

The invention discloses nutrition powder capable of reducing blood sugar and preventing diabetic complications and a preparation method of the nutrition powder. The nutrition powder comprises the following components in parts by weight: 20-45 parts of tartary buckwheat flour, 15-35 parts of highland barley flour, 1-8 parts of psyllium husk powder, 1-5 parts of oat beta-glucan, 1-4 parts of inulin, 0.2-1 part of aspartame, 10-25 parts of medicinal and edible food powder and 1-15 parts of medicinal and edible plant extract. Through reasonable compatibility of the tartary buckwheat, the highland barley, the oat beta-glucan, the inulin, the medicinal and edible food, the medicinal and edible food extract and the psyllium seed husk powder, a diabetic patient can have satiety, the intake of food is reduced, the postprandial blood sugar is balanced, the fasting blood-glucose level of the patient can be reduced, islet cells are favorably repaired, and the diabetes mellitus can be effectively treated. Meanwhile, diabetic complications can be prevented.

The present invention relates to a super-weatherable single-component aspartic acid polyurea self-cleaning reflective coating. The raw materials of the coating include, by weight, 5-10 parts of a modified light-control material dispersion, 5-10 parts of a super-hydrophobic modified isocyanate, 10-20 parts of an aspartic acid ester internal plasticizing latent amine, 10-20 parts of an aliphatic isocyanate, 15-45 parts of a polyol, 20-40 parts of a filler, and 0.2-0.6 parts of an auxiliary agent. The modified light-control material dispersion is an aspartic acid ester-modified light-control material dispersion; the super-hydrophobic modified isocyanate is an isocyanate modified with the modified light-control material dispersion and a low-surface-energy molecule; the aspartic acid ester internal plasticizing latent amine is obtained by reacting aspartic acid ester, cyclohexane, and an aldehyde-containing compound. The resulting coating has good weather resistance, more reasonable stress-strain properties, and wear resistance, as well as extremely excellent directional reflection and sunlight absorption capabilities, a self-cleaning effect, and a long duration.

This invention discloses a bacterial strain that degrades aspartame, a bacterial-algal symbiotic system, and its application. The strain is *Sphingosphomonas zeatus* (…). Sphingomonas zeae The specimen, NCU J1, with accession number CCTCC NO:M 20251462, was prepared using *Sphingomonas zeylans* and *Chlorella vulgaris*. Chlorella A directional symbiotic combination of *Sphingosine monocytogenes* sp. constructs a bacterial-algal symbiotic system. *Sphingosine monocytogenes* can metabolize aspartame and its degradation products, and can achieve metabolic complementarity through the bacterial-algal symbiotic interface. The bacteria preferentially promote the photohydrolysis of aspartame to generate degradation products such as diketopiperazine derivatives, while the microalgae simultaneously initiate isomerization enzymatic reactions to convert the degradation products into low-toxicity products. Compared with traditional physicochemical methods, this reduces the risk of secondary pollution by more than 40%, achieving efficient degradation of aspartame and significantly reducing the formation of its derivatives. It can be used to treat wastewater containing aspartame.

The present invention discloses a water-based anti-corrosion topcoat, a preparation method and application thereof, and an oil casing, relating to the technical field of oil casing anti-corrosion. The preparation method comprises the following steps: stirring 13.5 to 58.7 parts by mass of water, 0.1 to 0.5 parts of a wetting and dispersing agent, and 0.1 to 0.5 parts of a defoaming agent at 300 to 500 rpm; adding 10 to 20 parts of an anti-rust pigment and dispersing the mixture at 1200 to 1500 rpm to a fineness of ≤25 μm; adding 15 to 20 parts of a water-based acrylic resin and 10 to 30 parts of a water-based aspartame polyurea resin and stirring the mixture at 790 to 810 rpm for 9 to 10 minutes; adding 0.1 to 0.5 parts of an adhesion promoter, 5 to 10 parts of a film-forming aid, and 1 to 5 parts of a thickener, stirring the mixture at 36 to 40°C, and adjusting the viscosity to 80 to 100 KU. The paint film formed by the prepared water-based anti-corrosion topcoat has a salt spray resistance of ≥1000h and an adhesion of level 0.

The invention discloses a digestion-aiding lactein tablet and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The method comprises the following steps: firstly, mixing lactein, cane sugar, aspartame, milk-flavored essence and talcum powder, granulating, adding magnesium stearate, uniformly mixing, and pressing into tablet cores; then preparing a coating solution containing hydroxypropyl methylcellulose, Tween 80, amphiphilic nano lamellar magnesium-aluminum layered double hydroxides, amphiphilic mesoporous silica-zinc oxide hybrid particles, ethyl oleate and polyethylene glycol 400, and then preparing the coating solution containing hydroxypropyl methylcellulose, Tween 80, amphiphilic nano lamellar magnesium-aluminum layered double hydroxides, amphiphilic mesoporous silica-zinc oxide hybrid particles, ethyl oleate and polyethylene glycol 400; and finally, spraying the coating liquid on the surface of the tablet core to obtain a finished product. According to the method, two amphiphilic nano materials prepared by adopting a specific process are combined with coating components to form a coating layer with a specific function. The prepared lactein tablet can effectively protect the core component and improve the action effect of the core component in the intestinal tract, so that the better functions of helping digestion and regulating the intestinal flora are synergistically exerted.

The invention relates to the technical field of compound synthesis, in particular to a neotame preparation method which comprises the following steps: adding 3, 3-dimethylbutyraldehyde, aspartame, acetic acid and a raney nickel catalyst into a methanol solvent to obtain a first mixed solution, introducing hydrogen into the first mixed solution to carry out hydrogenation reduction reaction, and after the hydrogenation reduction reaction is finished, separating and purifying to obtain neotame. The acetic acid is used for inhibiting the transesterification side reaction caused by the methanol solvent; performing reduced pressure distillation on the second mixed solution, adding an alkaline regulator to regulate the pH value of the second mixed solution, separating out a neotame crude product, and refining and purifying the neotame crude product to obtain neotame. Therefore, the crystallization efficiency and the product purity of the neotame crude product are improved.