The invention belongs to the technical field of cosmetics and particularly relates to anti-wrinkle essence and a preparing method thereof. The anti-wrinkle essence is prepared from cyclomethicone, butanediol, polydimethylsiloxane, poly(sodium L-glutamate), glycerinum, propylene glycol, polyglycerol-10, dipropylene glycol, erythritol, hydroxyethyl acrylate/acryloyl 2 methyl taurine sodium copolymer, bio-saccharide gum, xylitol, C20-22 alcohol phosphate/C20-22 alcohol, lactic acid bacillus/ pomegranate fruit extracts of fermented products, arctic rock chlamydomonas essence, starfish essence, hexapeptide-3, orange flower essence, gentian root extracts, arbutin, milk protein, tranexamic acid and the like. The anti-wrinkle essence is good in permeability and easy to absorb, effective moisturizing is achieved, skin wrinkles are repaired and inhibited from being regenerated, and skin aging is delayed.