318 results about "Colloidal Silicon Dioxide" patented technology

The invention relates to the technical field of magnetic materials, in particular to high-performance samarium-iron-nitrogen powder and a preparation method and application thereof. The invention provides a preparation method of samarium-iron-nitrogen powder, which comprises the following steps: (1) mixing Sm2O3 powder, Fe powder and a Ca reducing agent, and carrying out reduction reaction to obtain samarium-iron alloy; (2) mixing and crushing the samarium-iron alloy, mixing the crushed samarium-iron alloy with a dispersant and a passivation solution, carrying out ball milling, separating, and drying to obtain samarium-iron alloy powder; (3) nitriding the samarium-iron alloy powder to obtain samarium-iron-nitrogen powder; wherein the dispersing agent is selected from at least one of alkali metal phosphates; the passivation solution comprises chromium chloride, nitric acid, sulfuric acid and colloidal silicon dioxide. The samarium-iron-nitrogen powder prepared through the method has good magnetic performance.

The invention discloses a preparation method of perindopril amlodipine tablets, and belongs to the field of pharmacy. The perindopril amlodipine tablet is prepared from the following raw material medicines: arginine perindopril and amlodipine besylate and auxiliary materials: lactose, microcrystalline cellulose, hydrophobic colloidal silicon dioxide and magnesium stearate. The preparation method of the perindopril amlodipine tablet comprises the following steps: weighing according to the prescription amount, crushing and sieving the raw materials for pretreatment, sieving the whole particles of the auxiliary materials for pretreatment, premixing, feeding and total mixing, tabletting and the like. The prepared perindopril amlodipine tablet is relatively good in quality, high in stability and relatively few in waste products.

Even when used for polishing a semiconductor wafer provided with a silicon nitride film, there is provided sulfonic acid-modified colloidal silica capable of forming a highly flat polished surface at high speed. Sulfonic acid-modified colloidal silica, wherein the sulfur content of the silica particles is 700 mass ppm or more and less than 3000 mass ppm per 1 g of the silica particles, the sulfur content in the solvent is 250 mass ppm or less per 1 g of the solvent, and the content of coarse particles having a particle size of 0.2 μm or more contained in the silica particles is 10,000,000 particles / mL or less when the silica particle concentration is 1 mass%.

The invention relates to the technical field of pharmaceutical preparations, in particular to a stable perindopril amlodipine tablet and a preparation method thereof, and the tablet comprises the following components in percentage by weight: 5.0% of arginine perindopril; 3.5% of amlodipine besylate; 20%-40% of pregelatinized starch; 40%-68% of a microcrystalline cellulose colloidal silicon dioxide compound; 2.5%-6% of a disintegrating agent, wherein the disintegrating agent is selected from one or more of ion exchange resin, sodium alginate and croscarmellose sodium; the pregelatinized starch and the microcrystalline cellulose colloidal silicon dioxide compound are selected as main diluents, so that the Maillard reaction possibly occurring between the lactose and the active pharmaceutical ingredients is completely avoided, the problem of increase of related substances is fundamentally solved, and the stability and the safety of the product are remarkably improved.

A polishing liquid which reduces the occurrence of erosion and scratches on a surface to be polished of an object to be polished having a cobalt-containing film after polishing in a case where the polishing liquid is applied to CMP of the object to be polished is provided. In addition, a chemical mechanical polishing method using the above-mentioned polishing liquid is provided. The polishing liquid is a polishing liquid used for chemical mechanical polishing of an object to be polished having a cobalt-containing film. The polishing liquid includes colloidal silica, an organic acid, a specific nitrogen-containing aromatic heterocyclic compound and hydrogen peroxide, and has a pH of 8.5 to 12.

The invention discloses granules of a composition containing rhizoma polygonati. The granules comprise the following components in percentage by weight: 30%-50% of composition dry paste powder, 38%-58% of a filling agent, 0.1%-20% of an adhesive and 0.1%-2% of a flow aid, the composition comprises rhizoma polygonati, fructus lycii, flos chrysanthemi and radix glehniae. Wherein the filling agent is dextrin; wherein the adhesive is maltodextrin or povidone; wherein the flow aid is colloidal silicon dioxide. According to the composition disclosed by the invention, proper auxiliary materials and an adding mode thereof are selected, so that the inherent properties of the original extract are improved, the extract is not easy to soften, the caking tendency caused by moisture absorption or heat absorption among particles is avoided, and the caking probability is reduced.

To provide colloidal silica in a single nano-size or a small particle size close to the single nano-size, in which its agglomeration does not substantially occur, and a method of producing the same.SOLUTION: The colloidal silica is characterized by being surface modified, having a BET diameter of not larger than 12 nm, and being not substantially agglomerated. The method of producing the colloidal silica is characterized by including a raw material preparation step of supplying easily decomposable organo-silicate to a reaction liquid including a hydrolysis catalyst consisting of an organic amine to make the organo-silicate react with the reaction liquid, to prepare raw material colloidal silica having a BET diameter of not larger than 12 mn, a concentration adjustment step of adjusting the solid content concentration of the raw material colloidal silica to not greater than 13 mass% and adjusting the concentration of the alcohol formed in the raw material preparation step to 1 to 25 mass%, a modification step of modifying the raw material colloidal silica of which concentration has been adjusted, and a concentration step of concentrating the content of residual organic solvent in the colloidal silica which has been modified, to be not greater than 1 mass%.SELECTED DRAWING: Figure 1

The invention provides a preparation method of a surface layer shell for precise casting production of a thick-wall titanium alloy. The preparation method comprises the following steps: S1, preparing a surface layer binder, wherein the surface layer binder comprises modified silica sol, a stabilizer, a reinforcing agent, a wetting agent and an acid-base regulator; the modified silica sol is diluted sodium-stabilized alkaline colloidal silicon dioxide; s2, preparing surface layer refractory powder, wherein the surface layer refractory powder comprises yttrium oxide powder, zirconium oxide powder and calcium fluoride powder; s3, preparing a surface layer coating; adding the surface layer refractory powder in the step S2 into the surface material binder in the step S1; s4, preparation of a surface layer shell, specifically, a module for preparing the surface layer shell enters the surface layer coating in the S3 to be subjected to slurry hanging, sand spraying and drying, and the step is repeated 1-2 times; and S5, the surface layer shell in the step S4 is subjected to firing forming, and the surface layer shell for precise casting production of the thick-wall titanium alloy is obtained. The surface layer shell obtained through the preparation method can be used for producing titanium alloy castings with the wall thickness ranging from 25 mm to 50 mm.

The present application provides a preparation method for a thermally expandable microsphere containing hydrophilic organic-modified colloidal silicon dioxide. In the preparation method, hydrophilic organic-modified colloidal silicon dioxide is mixed with a mixture of a monomer material capable of polymerizing to form a thermoplastic polymer shell and at least one foaming agent to form an emulsion, and the emulsion is polymerized to form the thermally expandable microsphere. Surface-modified colloidal silicon dioxide with hydrophilic organic group in the present application has good salt tolerance stability, can be stabilized in brine and is beneficial to the preparation of the thermally expandable microsphere; and the prepared microsphere has a narrow particle size distribution, can be easily dispersed in water and an organic system, and has good wettability. The application also relates to a thermally expandable microsphere and use thereof.

The present invention relates generally to methods of producing, using, and storing stable aqueously dispersed superhydrophobic compositions made from these compositions to provide superhydrophobic treatments on a range of porous, semi-porous, and non-porous target materials and surfaces as well as combinations of these materials and surfaces. More particularly, the present invention provides stably dispersed waterborne superhydrophobic compositions comprising colloidal silica or hydrophobically-modified silicon dioxide (i.e., silica) and one or more additional agents and / or compounds. When the compositions of the present invention are applied (e.g., via spray deposition, immersion, liquid application, and the like) to a suitable target material and / or surface the target is imparted with a durable (super)hydrophobic coating.

This application relates to the technical field of pharmaceutical preparations, and specifically discloses a pharmaceutical composition containing ibrutinib and its preparation method. The composition includes the active ingredient ibrutinib, colloidal silicon dioxide, solubilizers, and other excipients such as excipients; its preparation method is: the active ingredient ibrutinib is preferentially mixed with colloidal silicon dioxide and solubilizers, followed by dry granulation, mixing, and capsule filling. The composition of this application can be used for the treatment of diseases such as mantle cell lymphoma (MCL) / chronic lymphocytic leukemia (CLL) / small lymphocytic lymphoma, etc. It can effectively break the insoluble complex salt formed by ibrutinib and solubilizers, and has the advantages of fast dissolution rate and significantly improved bioavailability; in addition, the preparation method of this application has the advantages of good process reproducibility, simple process steps, low production cost, and being suitable for large-scale industrial production.

Provided is a coated article comprising a resinous base, a primer layer disposed on the resinous base, a hardcoat layer disposed on the primer layer, and an optically modified layer formed on a surface-layer portion of the hardcoat layer, wherein the primer layer is a cured coating film formed from a primer composition comprising (A) a vinyl-based (co)polymer and (B) inorganic particles having a given median diameter, the vinyl-based (co)polymer (A) including (A-1) a vinyl-based (co)polymer having an alkoxysilyl group and the primer layer having a thickness of 1-20 µm, and the hardcoat layer is a cured coating film formed from a silicone composition comprising (a) a silicone resin, (b) colloidal silica, and (c) an ultraviolet absorber, the hardcoat layer having a thickness of 1-15 µm.

The present invention provides a sulfonic acid-modified colloidal silica which has excellent long-term stability of metal adsorption amount and is capable of suppressing the amount of residual abrasive grains on a polished metal surface after polishing and cleaning.　This sulfonic acid-modified colloidal silica contains silica particles, and is characterized in that: (1) the surfaces of the silica particles are modified with a sulfonic acid group; (2) the Cu ion adsorption amount of the silica particles is 5.00-110.00 µmol / g; (3) the ratio (Cu ion adsorption amount (µmol / g) / S content (µmol / g)) of the Cu ion adsorption amount to the S content of the silica particles is 0.50 or more; and (4) the rate of change over time of the Cu ion adsorption amount of the silica particles is 1.30 or less as measured by the measurement method described below. [Measurement method of the rate of change over time of the Cu ion adsorption amount of the silica particles] The sulfonic acid-modified colloidal silica is left to stand at 25°C for 3 months. The Cu ion adsorption amount (µmol / g) of the silica particles before standing and the Cu ion adsorption amount (µmol / g) of the silica particles after standing are measured and the rate of change over time of the Cu ion adsorption amount of the silica particles is calculated by the following formula. (Rate of change over time of Cu ion adsorption amount of silica particles) = (Cu ion adsorption amount (µmol / g) of silica particles after standing) / (Cu ion adsorption amount (µmol / g) of silica particles before standing)

Provided is a colloidal silica which, when used as an abrasive grain for polishing, hardly leaves silica particles on the polished surface and can form a polished surface with reduced surface roughness. A colloidal silica in which silica particles are dispersed in a solvent, wherein the true specific gravity of the silica particles by the liquid phase substitution method is 1.60 or more and 2.20 or less, and the value of composite parameter 1 calculated by a specific formula is 10 or more and 200 or less.

The invention discloses a bisoprolol amlodipine compound tablet and a preparation process thereof, and the preparation method comprises the following steps: mixing bisoprolol or a pharmaceutically acceptable salt thereof with microcrystalline cellulose, carboxymethyl starch sodium, colloidal silicon dioxide and anhydrous citric acid according to a ratio, and carrying out dry granulation to obtain bisoprolol particles; the amlodipine or the pharmaceutically acceptable salt thereof, microcrystalline cellulose, carboxymethyl starch sodium, colloidal silicon dioxide and anhydrous citric acid are subjected to dry granulation in proportion, and amlodipine granules are obtained; the preparation method comprises the following steps: uniformly mixing bisoprolol particles and amlodipine particles, and uniformly mixing with a lubricant to obtain total mixed particles; and tabletting the total mixed particles to obtain the bisoprolol amlodipine compound tablet. According to the process, a relatively complex double-layer tablet process is not adopted, and the two active ingredients can be substantially separated, so that the operation can be effectively simplified, and the stability of the product can be improved.

The invention relates to the technical field of pharmaceutical preparations. Specifically, the invention relates to a sitafloxacin tablet and a preparation method thereof. The sitafloxacin tablet comprises (1) a solid dispersion which comprises (a) an active component which is sitafloxacin sesquihydrate and accounts for 15%-30% of the total weight of the tablet, (b) a solid dispersion carrier which is copovidone and accounts for 45%-65% of the total weight of the tablet, and (c) a stabilizer which is colloidal silicon dioxide and accounts for 0.1%-2.2% of the total weight of the tablet; (2) a filler accounting for 10-40% of the total weight of the tablet; (3) an adhesive accounting for 1%-5% of the total weight of the tablet; (4) a disintegrating agent accounting for 0.5-3% of the total weight of the tablet; and (5) a lubricant accounting for 0.2%-1.0% of the total weight of the tablet.

There is provided a pharmaceutical dosage form that is suitable for peroral administration to the gastrointestinal tract, which dosage form comprises a pharmaceutical composition in the form of a particulate mixture comprising solid particles of N-butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-iso-butylthiophene-2-sulfonamide (C21), or a pharmaceutically-acceptable salt thereof, admixed with a blend of carrier particles with weight- and / or a volume-based mean diameter, and / or a structural / particle density, that is / are similar to the weight- and / or volume-based mean diameter, and / or the structural / particle density, of the solid particles of C21, and a glidant, which composition is contained within a capsule that is suitable for such peroral administration. Preferred carrier particles have a weight- and / or a volume-based mean diameter that is less than about 100 μm. Preferred carrier particle materials include mannitol. Preferred glidants comprise colloidal silica. Such dosage forms find utility in the treatment of lung diseases, such as idiopathic pulmonary fibrosis, sarcoidosis and respiratory virus-induced tissue damage.

The invention discloses a mianserin hydrochloride tablet prepared in a wet granulation mode. The mianserin hydrochloride tablet is prepared from mianserin hydrochloride anhydride, calcium hydrogen phosphate, corn starch, hydroxypropyl methylcellulose, colloidal silicon dioxide, magnesium stearate and a film coating agent. According to the mianserin hydrochloride tablet and the preparation method thereof, the stability of the mianserin hydrochloride tablet is improved by using the high-concentration adhesive solution and optimizing the granulation parameter range, the problem that related substances are increased due to crystal transformation of active ingredients in the product preparation process is solved, and the medication safety of patients is better guaranteed.

Provided is a water-based inorganic coating agent capable of forming a coating film having high antifouling properties and excellent abrasion resistance. The aqueous inorganic coating agent includes colloidal silica, at least one of a sodium phosphate compound and a potassium phosphate compound, boric acid, aluminum monophosphate, and water.

Problems addressed by the present invention are to provide a lubricant composition that is capable of being used as an alternative to chemical conversion treatment by means of phosphate, to provide a lubricant composition having practical stable lubricative performance without the need for additional unwanted operations, and to provide a method for using this to form a lubrication coating, and a metal workpiece at which a lubrication coating is formed on a surface thereof. Provided as a means for solving such problems is a lubricant composition for causing formation of a hemimorphite-containing lubrication coating that contains a silicate compound (e.g., colloidal silica) and water-soluble zinc in solution.

The invention relates to a sample preparation method for EBSD detection of a MoSi target material, and the sample preparation method comprises the following steps: carrying out cutting, grinding treatment, mechanical polishing and chemical mechanical polishing on the MoSi target material in sequence to obtain a to-be-detected sample; a polishing solution adopted in the chemical mechanical polishing treatment comprises a basic solution, an acid solution and colloidal silicon dioxide, the polishing solution comprises 0.5-1 part by weight of the acid solution based on 100 parts by weight of the basic solution, and the concentration of the acid solution is 5-10 wt%; the MoSi target material sample prepared through the sample preparation method is smooth in surface, the roughness is as low as nanoscale, no obvious scratches exist, when the MoSi target material sample is used for EBSD detection, a diffraction Kikuchi zone is clear, the sample calibration rate reaches up to 90% or above, and a reliable detection sample is provided for research of microstructure characteristics of the MoSi material.

A composition comprises an aqueous dispersion of polymer particles, polymeric organic crosslinked microspheres, and colloidal silica particles. The composition is useful in coating compositions for exterior applications to achieve a balance of excellent dirt pickup resistance and durability performance under accelerated testing conditions.

The present disclosure is directed to coating compositions that include about 10 wt. % to about 90 wt. % water, about 5 wt. % to about 80 wt. % of a binder, and about 0.1 wt. % to about 20 wt. % of a colloidal silica functionalized with anionic molecules and / or a colloidal silica functionalized with neutral molecules. The present disclosure also is directed to methods of making coating compositions of the present technology.

The invention relates to the technical field of polishing solutions, in particular to a low-roughness polishing solution for fine polishing of silicon wafers and a preparation method of the low-roughness polishing solution. 20 to 40 parts of modified cerium oxide; 19.5 to 48 parts of a functional additive; 1.5 to 4.5 parts of a dispersion stabilizing system; 0.1 to 0.5 part of a surfactant; and 660 to 800 parts of ultrapure water. Monodisperse nano silicon dioxide colloid is synthesized through supercritical carbon dioxide, and surface damage caused by uneven grinding materials is eliminated from the source in combination with a crystal face regulation and control technology for activating cerium oxide through plasma; the activity of the oxidizing agent is locked by adopting an ultrasonic nano-encapsulation process, so that the service life of the polishing solution is greatly prolonged; and meanwhile, the synergistic effect of the abrasive materials is enhanced through oscillation curing and gradient doping processes, the sub-angstrom-level roughness is achieved, meanwhile, metal pollution is controlled at the ppt level, and a reliable surface treatment process is provided for manufacturing of chips with the diameters smaller than 3 nanometers.

The utility model discloses a colloidal silicon dioxide purification device, which relates to the technical field of silicon dioxide processing and comprises a purification cylinder, a filter frame fixed in the purification cylinder and adopting an annular structure, and a sealing seat arranged in an annular groove of the filter frame, an inverted circular-truncated-cone-shaped curved surface is arranged on the filter frame, and a filter screen is arranged on the curved surface; a rotating seat is rotationally mounted at the upper part of the sealing seat; a scraping plate attached to the filter screen is mounted on the side surface of the rotating seat through a bracket; a rotating table is rotationally installed on the lower portion of the sealing seat, a spiral transmission blade is arranged on the side face of the rotating table, and a rotating shaft of the rotating seat is fixedly connected with a rotating shaft of the rotating table through a connecting column in the sealing seat; when the filter screen is used for filtering, filtered materials fall on a transmission blade to push the transmission blade to rotate, and a rotating table drives a rotating seat to rotate synchronously, so that a scraping plate is attached to the filter screen to rotate to scrape the filter screen; impurities are effectively prevented from blocking the filter screen.

A method for synthesizing a mesoporous nano-sized ultra-stable Y zeolite includes adding sodium aluminate and colloidal silica to an aqueous NaOH solution and mixing to form a hydrogel having the following molar ratio composition: Na2O: Al2O3: SiO2: 200 to 400 H2O in the range of 8 to 12. The method further includes heating the hydrogel to an autoclave to form a zeolite precursor, filtering and washing the zeolite precursor to form a nano-sized Y zeolite. The method further includes combining the nano-sized Y zeolite with water to form a nano-sized Y zeolite slurry mixture, and then adding 0.1 M to 2.0 M of an aqueous ammonium hexafluorosilicate solution to form a dealumination solution. Finally, the method includes filtering and washing the dealuminated solution with water to form an ultra-stable Y zeolite precursor, drying the ultra-stable Y zeolite precursor, and calcining the dried zeolite precursor to form a nano-sized ultra-stable Y zeolite.

The application belongs to the technical field of electromagnetic wave absorbing materials, and particularly relates to a co-doped mesoporous carbon sphere wave absorbing material, a preparation method and an application. The preparation method comprises the following steps: aniline is added into a colloidal silica hydrochloric acid solution and uniformly mixed to obtain a mixed solution; then, ammonium persulfate hydrochloric acid solution is added into the mixed solution and uniformly mixed; drying is performed to obtain a precursor; the precursor is calcined under a protective atmosphere to obtain an intermediate; then, the intermediate and a sodium hydroxide solution are mixed, heated, and treated to obtain the co-doped mesoporous carbon sphere wave absorbing material. The calcination method comprises the following steps: the precursor is heated to 250-350 DEG C under a protective atmosphere and then heated to 700-900 DEG C for calcination. The co-doped mesoporous carbon sphere wave absorbing material has excellent wave absorbing performance.

The application of geocatalysts in controlling CO2 capture processes in situ as well as in a reaction vessel, chamber or tower is described. More specifically, a process for controlling the reaction of a CO2-containing gas stream with one or more starting materials selected from waste building material, mineral, rock, sand, amorphous material or combinations thereof is disclosed: wherein said starting material comprises Si and / or Al, and one or more divalent cation(s), water, and one or more organic compound(s) to control the reaction: thereby providing a product comprising: at least one carbonate mineral and preferably colloidal silica.

The invention relates to the technical field of furosemide tablets, in particular to a furosemide tablet and a preparation method thereof. The furosemide tablet is prepared from the following raw materials in parts by weight: 20 to 25 parts of furosemide, 65 to 70 parts of filler, 1.6 to 10 parts of flow aid and 20 to 23 parts of adhesive, the flow aid comprises talcum powder, colloidal silicon dioxide and magnesium stearate. According to the furosemide tablet, the fluidity of furosemide can be improved, the mixing uniformity of the raw materials can be improved, the sticking problem during tabletting can be avoided, the tabletting smoothness can be improved, the dissolution property of the furosemide tablet can be improved, and the dissolution rate of the furosemide tablet can be improved.

A nasal pharmaceutical composition comprising a porous excipient and an active agent, wherein the active agent is loaded onto a surface of the porous excipient located within pores of the porous excipient, wherein the porous excipient is an inorganic porous material selected from colloidal silicon dioxide, mesoporous silica, microporous silica and macroporous silica, and wherein the loaded porous excipient is dispersed in a gel, the gel comprising a vehicle comprising an oil or a mixture of oils, and wherein the composition is designed for nasal administration.