244 results about "Colloidal Silicon Dioxide" patented technology

The invention discloses a preparation method of perindopril amlodipine tablets, and belongs to the field of pharmacy. The perindopril amlodipine tablet is prepared from the following raw material medicines: arginine perindopril and amlodipine besylate and auxiliary materials: lactose, microcrystalline cellulose, hydrophobic colloidal silicon dioxide and magnesium stearate. The preparation method of the perindopril amlodipine tablet comprises the following steps: weighing according to the prescription amount, crushing and sieving the raw materials for pretreatment, sieving the whole particles of the auxiliary materials for pretreatment, premixing, feeding and total mixing, tabletting and the like. The prepared perindopril amlodipine tablet is relatively good in quality, high in stability and relatively few in waste products.

The invention relates to the technical field of pharmaceutical preparations, in particular to a stable perindopril amlodipine tablet and a preparation method thereof, and the tablet comprises the following components in percentage by weight: 5.0% of arginine perindopril; 3.5% of amlodipine besylate; 20%-40% of pregelatinized starch; 40%-68% of a microcrystalline cellulose colloidal silicon dioxide compound; 2.5%-6% of a disintegrating agent, wherein the disintegrating agent is selected from one or more of ion exchange resin, sodium alginate and croscarmellose sodium; the pregelatinized starch and the microcrystalline cellulose colloidal silicon dioxide compound are selected as main diluents, so that the Maillard reaction possibly occurring between the lactose and the active pharmaceutical ingredients is completely avoided, the problem of increase of related substances is fundamentally solved, and the stability and the safety of the product are remarkably improved.

A polishing liquid which reduces the occurrence of erosion and scratches on a surface to be polished of an object to be polished having a cobalt-containing film after polishing in a case where the polishing liquid is applied to CMP of the object to be polished is provided. In addition, a chemical mechanical polishing method using the above-mentioned polishing liquid is provided. The polishing liquid is a polishing liquid used for chemical mechanical polishing of an object to be polished having a cobalt-containing film. The polishing liquid includes colloidal silica, an organic acid, a specific nitrogen-containing aromatic heterocyclic compound and hydrogen peroxide, and has a pH of 8.5 to 12.

The invention discloses granules of a composition containing rhizoma polygonati. The granules comprise the following components in percentage by weight: 30%-50% of composition dry paste powder, 38%-58% of a filling agent, 0.1%-20% of an adhesive and 0.1%-2% of a flow aid, the composition comprises rhizoma polygonati, fructus lycii, flos chrysanthemi and radix glehniae. Wherein the filling agent is dextrin; wherein the adhesive is maltodextrin or povidone; wherein the flow aid is colloidal silicon dioxide. According to the composition disclosed by the invention, proper auxiliary materials and an adding mode thereof are selected, so that the inherent properties of the original extract are improved, the extract is not easy to soften, the caking tendency caused by moisture absorption or heat absorption among particles is avoided, and the caking probability is reduced.

The present invention provides a sulfonic acid-modified colloidal silica which has excellent long-term stability of metal adsorption amount and is capable of suppressing the amount of residual abrasive grains on a polished metal surface after polishing and cleaning.　This sulfonic acid-modified colloidal silica contains silica particles, and is characterized in that: (1) the surfaces of the silica particles are modified with a sulfonic acid group; (2) the Cu ion adsorption amount of the silica particles is 5.00-110.00 µmol / g; (3) the ratio (Cu ion adsorption amount (µmol / g) / S content (µmol / g)) of the Cu ion adsorption amount to the S content of the silica particles is 0.50 or more; and (4) the rate of change over time of the Cu ion adsorption amount of the silica particles is 1.30 or less as measured by the measurement method described below. [Measurement method of the rate of change over time of the Cu ion adsorption amount of the silica particles] The sulfonic acid-modified colloidal silica is left to stand at 25°C for 3 months. The Cu ion adsorption amount (µmol / g) of the silica particles before standing and the Cu ion adsorption amount (µmol / g) of the silica particles after standing are measured and the rate of change over time of the Cu ion adsorption amount of the silica particles is calculated by the following formula. (Rate of change over time of Cu ion adsorption amount of silica particles) = (Cu ion adsorption amount (µmol / g) of silica particles after standing) / (Cu ion adsorption amount (µmol / g) of silica particles before standing)

There is provided a pharmaceutical dosage form that is suitable for peroral administration to the gastrointestinal tract, which dosage form comprises a pharmaceutical composition in the form of a particulate mixture comprising solid particles of N-butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-iso-butylthiophene-2-sulfonamide (C21), or a pharmaceutically-acceptable salt thereof, admixed with a blend of carrier particles with weight- and / or a volume-based mean diameter, and / or a structural / particle density, that is / are similar to the weight- and / or volume-based mean diameter, and / or the structural / particle density, of the solid particles of C21, and a glidant, which composition is contained within a capsule that is suitable for such peroral administration. Preferred carrier particles have a weight- and / or a volume-based mean diameter that is less than about 100 μm. Preferred carrier particle materials include mannitol. Preferred glidants comprise colloidal silica. Such dosage forms find utility in the treatment of lung diseases, such as idiopathic pulmonary fibrosis, sarcoidosis and respiratory virus-induced tissue damage.

The invention discloses a mianserin hydrochloride tablet prepared in a wet granulation mode. The mianserin hydrochloride tablet is prepared from mianserin hydrochloride anhydride, calcium hydrogen phosphate, corn starch, hydroxypropyl methylcellulose, colloidal silicon dioxide, magnesium stearate and a film coating agent. According to the mianserin hydrochloride tablet and the preparation method thereof, the stability of the mianserin hydrochloride tablet is improved by using the high-concentration adhesive solution and optimizing the granulation parameter range, the problem that related substances are increased due to crystal transformation of active ingredients in the product preparation process is solved, and the medication safety of patients is better guaranteed.

Provided is a water-based inorganic coating agent capable of forming a coating film having high antifouling properties and excellent abrasion resistance. The aqueous inorganic coating agent includes colloidal silica, at least one of a sodium phosphate compound and a potassium phosphate compound, boric acid, aluminum monophosphate, and water.

The invention relates to a sample preparation method for EBSD detection of a MoSi target material, and the sample preparation method comprises the following steps: carrying out cutting, grinding treatment, mechanical polishing and chemical mechanical polishing on the MoSi target material in sequence to obtain a to-be-detected sample; a polishing solution adopted in the chemical mechanical polishing treatment comprises a basic solution, an acid solution and colloidal silicon dioxide, the polishing solution comprises 0.5-1 part by weight of the acid solution based on 100 parts by weight of the basic solution, and the concentration of the acid solution is 5-10 wt%; the MoSi target material sample prepared through the sample preparation method is smooth in surface, the roughness is as low as nanoscale, no obvious scratches exist, when the MoSi target material sample is used for EBSD detection, a diffraction Kikuchi zone is clear, the sample calibration rate reaches up to 90% or above, and a reliable detection sample is provided for research of microstructure characteristics of the MoSi material.

A composition comprises an aqueous dispersion of polymer particles, polymeric organic crosslinked microspheres, and colloidal silica particles. The composition is useful in coating compositions for exterior applications to achieve a balance of excellent dirt pickup resistance and durability performance under accelerated testing conditions.

The present disclosure is directed to coating compositions that include about 10 wt. % to about 90 wt. % water, about 5 wt. % to about 80 wt. % of a binder, and about 0.1 wt. % to about 20 wt. % of a colloidal silica functionalized with anionic molecules and / or a colloidal silica functionalized with neutral molecules. The present disclosure also is directed to methods of making coating compositions of the present technology.

The invention relates to the technical field of polishing solutions, in particular to a low-roughness polishing solution for fine polishing of silicon wafers and a preparation method of the low-roughness polishing solution. 20 to 40 parts of modified cerium oxide; 19.5 to 48 parts of a functional additive; 1.5 to 4.5 parts of a dispersion stabilizing system; 0.1 to 0.5 part of a surfactant; and 660 to 800 parts of ultrapure water. Monodisperse nano silicon dioxide colloid is synthesized through supercritical carbon dioxide, and surface damage caused by uneven grinding materials is eliminated from the source in combination with a crystal face regulation and control technology for activating cerium oxide through plasma; the activity of the oxidizing agent is locked by adopting an ultrasonic nano-encapsulation process, so that the service life of the polishing solution is greatly prolonged; and meanwhile, the synergistic effect of the abrasive materials is enhanced through oscillation curing and gradient doping processes, the sub-angstrom-level roughness is achieved, meanwhile, metal pollution is controlled at the ppt level, and a reliable surface treatment process is provided for manufacturing of chips with the diameters smaller than 3 nanometers.

The utility model discloses a colloidal silicon dioxide purification device, which relates to the technical field of silicon dioxide processing and comprises a purification cylinder, a filter frame fixed in the purification cylinder and adopting an annular structure, and a sealing seat arranged in an annular groove of the filter frame, an inverted circular-truncated-cone-shaped curved surface is arranged on the filter frame, and a filter screen is arranged on the curved surface; a rotating seat is rotationally mounted at the upper part of the sealing seat; a scraping plate attached to the filter screen is mounted on the side surface of the rotating seat through a bracket; a rotating table is rotationally installed on the lower portion of the sealing seat, a spiral transmission blade is arranged on the side face of the rotating table, and a rotating shaft of the rotating seat is fixedly connected with a rotating shaft of the rotating table through a connecting column in the sealing seat; when the filter screen is used for filtering, filtered materials fall on a transmission blade to push the transmission blade to rotate, and a rotating table drives a rotating seat to rotate synchronously, so that a scraping plate is attached to the filter screen to rotate to scrape the filter screen; impurities are effectively prevented from blocking the filter screen.

The application belongs to the technical field of electromagnetic wave absorbing materials, and particularly relates to a co-doped mesoporous carbon sphere wave absorbing material, a preparation method and an application. The preparation method comprises the following steps: aniline is added into a colloidal silica hydrochloric acid solution and uniformly mixed to obtain a mixed solution; then, ammonium persulfate hydrochloric acid solution is added into the mixed solution and uniformly mixed; drying is performed to obtain a precursor; the precursor is calcined under a protective atmosphere to obtain an intermediate; then, the intermediate and a sodium hydroxide solution are mixed, heated, and treated to obtain the co-doped mesoporous carbon sphere wave absorbing material. The calcination method comprises the following steps: the precursor is heated to 250-350 DEG C under a protective atmosphere and then heated to 700-900 DEG C for calcination. The co-doped mesoporous carbon sphere wave absorbing material has excellent wave absorbing performance.

The invention relates to the technical field of furosemide tablets, in particular to a furosemide tablet and a preparation method thereof. The furosemide tablet is prepared from the following raw materials in parts by weight: 20 to 25 parts of furosemide, 65 to 70 parts of filler, 1.6 to 10 parts of flow aid and 20 to 23 parts of adhesive, the flow aid comprises talcum powder, colloidal silicon dioxide and magnesium stearate. According to the furosemide tablet, the fluidity of furosemide can be improved, the mixing uniformity of the raw materials can be improved, the sticking problem during tabletting can be avoided, the tabletting smoothness can be improved, the dissolution property of the furosemide tablet can be improved, and the dissolution rate of the furosemide tablet can be improved.

A nasal pharmaceutical composition comprising a porous excipient and an active agent, wherein the active agent is loaded onto a surface of the porous excipient located within pores of the porous excipient, wherein the porous excipient is an inorganic porous material selected from colloidal silicon dioxide, mesoporous silica, microporous silica and macroporous silica, and wherein the loaded porous excipient is dispersed in a gel, the gel comprising a vehicle comprising an oil or a mixture of oils, and wherein the composition is designed for nasal administration.

The invention belongs to the field of contact lens care, and particularly relates to a sandwich effervescent tablet for cleaning contact lenses and a preparation method of the sandwich effervescent tablet. The outer layer is prepared from the following raw materials: citric acid, sodium bicarbonate, disodium ethylene diamine tetraacetate, a surfactant, polyvinylpyrrolidone, microcrystalline cellulose and colloidal silicon dioxide; the middle layer is prepared from the following raw materials in parts by weight: sodium percarbonate, tetraacetylethylenediamine, phosphate buffer salt, a surfactant, anhydrous sodium carbonate, microcrystalline cellulose and colloidal silicon dioxide; the inner core is prepared from the following raw materials in parts by weight: catalase, a stabilizer, hydroxy propyl cellulose K4M, ethyl cellulose, microcrystalline cellulose and sodium bicarbonate. According to the invention, citric acid / bicarbonate is matched with an active agent to weaken a biological membrane in the outer layer, and a permeation channel is opened preferentially; the H2O2 platform is formed by matching middle-layer sodium percarbonate; and the inner core adopts HPMC / EC controlled-release catalase to realize hysteresis-burst release neutralization.

The invention relates to the technical field of alloys, in particular to a magnesium alloy spraying pretreatment process. According to the process, after alkali washing and acid activation are conducted on magnesium alloy, pre-adsorption and main conversion treatment are conducted in sequence. Both the pre-adsorption liquid A and the main conversion liquid B contain polyether / zwitterionic modified colloidal silicon dioxide mother liquor, the mother liquor is obtained through amination, polyether, tertiary amination and zwitterionic modification of colloidal silicon dioxide, and the dispersion stability and interfacial compatibility of the colloidal silicon dioxide in an acidic fluorine-containing environment are remarkably improved. A uniform and compact conversion film is formed on the surface of the treated magnesium alloy, and the coating is high in binding force, high in corrosion resistance, excellent in appearance and suitable for high-end application such as 3C product shells.

The present disclosure provides oral dosage forms comprising about 8.75% w / w deuruxolitinib phosphate, about 50% to about 60% w / w microcrystalline cellulose, about 25% to about 35% w / w lactose monohydrate, about 3% to about 6% w / w polyvinylpyrrolidone, about 2% to about 4% w / w hydroxypropyl cellulose, about 0.25% to about 0.75% w / w colloidal silicon dioxide, and about 0.25% to about 0.75% w / w magnesium stearate.

The application belongs to the technical field of layered composite film preparation, and provides an online coating high-barrier biaxially stretched polyethylene film and a preparation method and application thereof. First, polyethylene multilayer sheet is co-extruded and longitudinally stretched, and a to-be-coated base film is obtained through corona activation; then, nano clusters are constructed from phytic acid and zirconium salt, and a hybrid dispersion liquid is formed by introducing tannic acid, polyallylamine hydrochloride and epoxy silane; at the same time, sodium-based montmorillonite and colloidal silicon dioxide are compounded under the action of tannic acid and treated by silane to obtain a barrier dispersion liquid; the barrier dispersion liquid, polyvinyl alcohol, polyvinylpyrrolidone and polyhydric alcohol are prepared into an aqueous coating composition, which is coated on the base film online, dried and solidified, and then transversely stretched to obtain a film with stable oxygen and water vapor barrier properties and suitable for packaging applications.

The present invention provides an aqueous inorganic coating agent capable of forming a highly stain-resistant film on various substrates. [Solution] An aqueous inorganic coating agent comprising colloidal silica, at least one of a sodium phosphate compound and a potassium phosphate compound, boric acid, an inorganic thickener, and water.

The present application relates to the technical field of welding material, in particular to a high-toughness gas shielded welding wire and a preparation method thereof.The welding wire comprises a low-carbon steel belt sheath and a flux cored powder, and the flux cored powder comprises reduced iron powder, manganese powder, carbonyl nickel powder, molybdenum powder, titanium powder, silicon powder, graphite powder, rutile titanium dioxide, calcium fluoride, potassium fluorotitanate and cerium-aluminum co-doped microparticle powder; the cerium-aluminum co-doped microparticle powder takes calcium-rich borosilicate as a core, is treated by isopropanol aluminum hydrolysis polycondensation sealing, aluminum oxide nanoparticle enhancement, aluminum nitrate-colloidal silicon dioxide bridging and cerium nitrate outer layer, and is prepared; the welding wire is suitable for high-strength steel thick plate multi-layer multi-pass gas shielded welding, can improve low-temperature impact toughness and refine inclusions while maintaining high deposited metal strength.

The invention discloses a galanthamine hydrobromide enteric-coated tablet and a preparation method thereof. The tablet is composed of a tablet core, an isolation layer and an enteric layer, the tablet core contains 5.0%-16.0% of galanthamine hydrobromide, and auxiliary materials such as mannitol, a mixture of magnesium stearate and sodium stearyl fumarate in a specific proportion, colloidal silicon dioxide and the like are matched; the isolating layer adopts an opadry II type film coating, and the enteric-coated layer adopts an opadry Acryl-EZE II type enteric-coated coating. The dissolution rate of the tablet in an acidic medium with the pH value of 1.2 for 2 hours is less than 5%, the release rate of the tablet in a medium with the pH value of 5.5 or 6.8 for 45 minutes is more than or equal to 80%, the tablet is sealed and placed at 40 DEG C + / -2 DEG C / 75% + / -5% RH for 6 months, the stability is good, and the pharmacokinetic parameters are excellent. The preparation method comprises the steps of raw and auxiliary material pretreatment, graded premixing, total mixing and lubricating, tabletting, two-step coating and the like, and the process is stable and controllable. The enteric-coated tablet disclosed by the invention is strong in targeted release property, high in stability and good in bioavailability, and can guarantee the effectiveness and safety of medication.

To provide a process for producing cationic colloidal silica which is surface-modified by at least one aminoalkoxysilane having an amino group in a cationic form.SOLUTION: The production method comprises (i) reacting, under alkaline conditions, negatively charged colloidal silica with at least one aminoalkoxysilane having an amino group in a cationic form at above 20°C to produce surface-modified colloidal silica having a net negative surface charge, and (ii) reversing the surface charge of the net negatively charged surface-modified colloidal silica by contacting the net negatively charged surface-modified colloidal silica with an ion exchange resin to obtain positively charged surface-modified colloidal silica.SELECTED DRAWING: Figure 1

A process for preparing a macroporous material comprising an active phase comprising a potassium phosphate salt and / or a cesium phosphate salt and a support comprising α-SiC silicon carbide and silica comprising the following steps: a) contacting a colloidal silica sol with a powder of a potassium and / or cesium phosphate salt to obtain a suspension; b) adding a powder of precipitated silica, a powder of α-SiC silicon carbide and a solvent to obtain a paste; c) shaping the paste to obtain a material precursor; d) drying the material precursor at a temperature between 15°C and 250°C; e) calcining the dried material precursor obtained at the end of step d) at a temperature above 250°C and below or equal to 1200°C.

The invention belongs to the technical field of coating preparation, and provides a fireproof heat-insulating nano ceramic coating for a lithium battery and a preparation method of the fireproof heat-insulating nano ceramic coating. The coating is a water-based two-component system, in a first component, bisphenol A diglycidyl ether, compound colloidal silicon dioxide, boehmite and nano zirconium oxide and / or nano aluminum oxide are used for constructing a ceramic skeleton, and aerogel, hollow glass beads, expanded vermiculite and / or flaky mica and inorganic fibers are combined to form a heat insulation network; the flame-retardant system contains ammonium polyphosphate, pentaerythritol, melamine components, zinc borate and sealing glass powder, silane interface bonding components and thermal expansion microspheres are introduced, an expansion thermal insulation layer is formed when the flame-retardant system is heated, and the flame-retardant system is densified into a hard shell at high temperature; the second component is a water dispersible amine curing agent; the preparation method comprises the following steps: adding the interface bonding components step by step, and sequentially compounding the inorganic phase and the flame-retardant heat-insulating phase to obtain the double-component packaged coating which is suitable for safety protection of a lithium battery system.

To provide an antibacterial and antiviral coat structure that can be applied to a surface of a metal or resin housing, and can exhibit antibacterial and antiviral properties not only in presence of light but also under a light-shielding condition.SOLUTION: The antibacterial and antiviral coat structure comprises a base layer and an antibacterial and antiviral layer provided on the base layer. The antibacterial and antiviral layer consists of a metal oxide-based photocatalyst and a quaternary ammonium salt-based silane. The coat structure is formed by: dispersing the metal oxide-based photocatalyst in a solvent; adding the quaternary ammonium salt-based silane to a dispersion to react; and applying a liquid after a reaction on a substrate to dry. Preferably, the antibacterial and antiviral layer contains colloidal silica.SELECTED DRAWING: Figure 1

The present invention provides a citric acid-containing colloidal silica in which the formation of coarse particles having a size of 0.20 μm or greater when a shear force is applied is suppressed.　The present invention is a citric acid-containing colloidal silica comprising silica particles and citric acid, the citric acid-containing colloidal silica being characterized in that (1) the density of silanol groups per unit surface area of the silica particles is 1.6 x 1019 to 14.5 x 1019 groups / m2, and (2) the content of citric acid per unit surface area of the silica particles is 1.0 to 10.0 μg / m2.

The application discloses an olmesartan medoxomil and amlodipine besylate pharmaceutical composition and a preparation method thereof, and belongs to the technical field of medicines. The olmesartan medoxomil and amlodipine besylate pharmaceutical composition takes olmesartan medoxomil and amlodipine besylate as active ingredients, and is prepared into antihypertensive tablets by being matched with a disintegrant, a filler and a lubricant; wherein the filler is a mixture of pre-gelatinized starch and a co-processed product of microcrystalline cellulose and colloidal silicon dioxide. The preparation method adopts a direct compression process, and sequentially comprises the steps of mixing, whole-granulating, twice mixing, lubricating, tabletting and stomach-soluble film coating, and is simple in process and suitable for industrialized scale-up production. The application effectively solves the problem of low dissolution rate of the existing olmesartan medoxomil and amlodipine besylate tablets, and the prepared tablets have the advantages of high dissolution rate, similar dissolution curve to commercial preparations, high bioavailability, stable quality and good clinical application value.

Provided are an ink jet ink, an ink set, and an image recording method, in which an image with an excellent covering property can be recorded and abrasion deterioration of an ink jet head can be suppressed. The ink jet ink is an ink jet ink including water, titanium dioxide particles, and a silicon compound, in which an average primary particle diameter of the titanium dioxide particles is 100 nm or greater, the silicon compound is at least one selected from the group consisting of a silicate and colloidal silica, a content of the silicon compound is 0.0020% by mass or greater with respect to a total amount of the titanium dioxide particles, and a ratio of a volume average particle diameter of the colloidal silica to the average primary particle diameter of the titanium dioxide particles is 0.04 or less.