410 results about "Colloidal Silicon Dioxide" patented technology

The present invention provides a colloidal silica in which the average secondary particle diameter of silica particles is small, and the dispersion stability of silica particles can be maintained over a long period even under strongly acidic conditions of pH 3. The present invention also provides a method for producing the colloidal silica.　The present invention provides a colloidal silica containing silica particles, wherein the colloidal silica is characterized in that: the silica particles have an average secondary particle diameter of 20 nm or less as measured by a dynamic light scattering; the zeta potential measured under conditions of pH 3 is -20 mV or less; and the surface of the silica particles is modified with a sulfonic acid group.

The invention relates to the technical field of magnetic materials, in particular to high-performance samarium-iron-nitrogen powder and a preparation method and application thereof. The invention provides a preparation method of samarium-iron-nitrogen powder, which comprises the following steps: (1) mixing Sm2O3 powder, Fe powder and a Ca reducing agent, and carrying out reduction reaction to obtain samarium-iron alloy; (2) mixing and crushing the samarium-iron alloy, mixing the crushed samarium-iron alloy with a dispersant and a passivation solution, carrying out ball milling, separating, and drying to obtain samarium-iron alloy powder; (3) nitriding the samarium-iron alloy powder to obtain samarium-iron-nitrogen powder; wherein the dispersing agent is selected from at least one of alkali metal phosphates; the passivation solution comprises chromium chloride, nitric acid, sulfuric acid and colloidal silicon dioxide. The samarium-iron-nitrogen powder prepared through the method has good magnetic performance.

The present invention provides a colloidal silica having few fine particles. Also provided is a method for producing a colloidal silica.

The invention discloses a preparation method of perindopril amlodipine tablets, and belongs to the field of pharmacy. The perindopril amlodipine tablet is prepared from the following raw material medicines: arginine perindopril and amlodipine besylate and auxiliary materials: lactose, microcrystalline cellulose, hydrophobic colloidal silicon dioxide and magnesium stearate. The preparation method of the perindopril amlodipine tablet comprises the following steps: weighing according to the prescription amount, crushing and sieving the raw materials for pretreatment, sieving the whole particles of the auxiliary materials for pretreatment, premixing, feeding and total mixing, tabletting and the like. The prepared perindopril amlodipine tablet is relatively good in quality, high in stability and relatively few in waste products.

Even when used for polishing a semiconductor wafer provided with a silicon nitride film, there is provided sulfonic acid-modified colloidal silica capable of forming a highly flat polished surface at high speed. Sulfonic acid-modified colloidal silica, wherein the sulfur content of the silica particles is 700 mass ppm or more and less than 3000 mass ppm per 1 g of the silica particles, the sulfur content in the solvent is 250 mass ppm or less per 1 g of the solvent, and the content of coarse particles having a particle size of 0.2 μm or more contained in the silica particles is 10,000,000 particles / mL or less when the silica particle concentration is 1 mass%.

The invention discloses a metformin empagliflozin tablet composition and a preparation method thereof. The metformin empagliflozin tablet composition is prepared from the following raw materials: metformin hydrochloride, empagliflozin, corn starch, copovidone, colloidal silicon dioxide, magnesium stearate and a gastric-soluble film coating premix. According to the metformin empagliflozin composition and the preparation method thereof, empagliflozin is dispersed in part of auxiliary materials, then mixing granulation is carried out through a wet granulator, empagliflozin and part of the auxiliary materials are premixed, and the particle size range of a metformin hydrochloride raw material is controlled, so that the problems of poor empagliflozin content uniformity and large inter-batch dissolution difference of the metformin empagliflozin composition prepared by a traditional process are solved; by controlling the mesh number of the wet granulation screen, the problems that materials adhere to the screen, discharging is difficult, and production efficiency is low in the wet granulation process are solved; compared with a fluidized bed production process, the equipment cost is low, the operation is simpler, and the production efficiency is higher; the pharmaceutical composition prepared by the preparation method disclosed by the invention is uniform in component mixing, simple to prepare, controllable in quality and consistent in in-vitro dissolution with an original preparation.

The invention relates to the technical field of pharmaceutical preparations, in particular to a stable perindopril amlodipine tablet and a preparation method thereof, and the tablet comprises the following components in percentage by weight: 5.0% of arginine perindopril; 3.5% of amlodipine besylate; 20%-40% of pregelatinized starch; 40%-68% of a microcrystalline cellulose colloidal silicon dioxide compound; 2.5%-6% of a disintegrating agent, wherein the disintegrating agent is selected from one or more of ion exchange resin, sodium alginate and croscarmellose sodium; the pregelatinized starch and the microcrystalline cellulose colloidal silicon dioxide compound are selected as main diluents, so that the Maillard reaction possibly occurring between the lactose and the active pharmaceutical ingredients is completely avoided, the problem of increase of related substances is fundamentally solved, and the stability and the safety of the product are remarkably improved.

A polishing liquid which reduces the occurrence of erosion and scratches on a surface to be polished of an object to be polished having a cobalt-containing film after polishing in a case where the polishing liquid is applied to CMP of the object to be polished is provided. In addition, a chemical mechanical polishing method using the above-mentioned polishing liquid is provided. The polishing liquid is a polishing liquid used for chemical mechanical polishing of an object to be polished having a cobalt-containing film. The polishing liquid includes colloidal silica, an organic acid, a specific nitrogen-containing aromatic heterocyclic compound and hydrogen peroxide, and has a pH of 8.5 to 12.

The invention discloses granules of a composition containing rhizoma polygonati. The granules comprise the following components in percentage by weight: 30%-50% of composition dry paste powder, 38%-58% of a filling agent, 0.1%-20% of an adhesive and 0.1%-2% of a flow aid, the composition comprises rhizoma polygonati, fructus lycii, flos chrysanthemi and radix glehniae. Wherein the filling agent is dextrin; wherein the adhesive is maltodextrin or povidone; wherein the flow aid is colloidal silicon dioxide. According to the composition disclosed by the invention, proper auxiliary materials and an adding mode thereof are selected, so that the inherent properties of the original extract are improved, the extract is not easy to soften, the caking tendency caused by moisture absorption or heat absorption among particles is avoided, and the caking probability is reduced.

To provide an aqueous ink composition capable of achieving both excellent discharge stability and storage stability over a long period of time even in an inkjet printhead having a nozzle having a stepped part having a smaller diameter toward the ink discharge direction.SOLUTION: There is provided an aqueous ink composition discharged from a nozzle having a stepped part having a smaller diameter toward the ink discharge direction, which comprises a pigment, a colloidal silica, more than 0.5 mass% of 1,2-hexanediol based on the total amount of the aqueous ink composition as a first solvent and 0.1 mass% or more and less than 4.0 mass% of an alcohol having a Hansen solubility parameter polarity term of 9 or less and a hydrogen bonding term of 17 or less based on the total amount of the aqueous ink composition as a second solvent.SELECTED DRAWING: Figure 1

To provide colloidal silica in a single nano-size or a small particle size close to the single nano-size, in which its agglomeration does not substantially occur, and a method of producing the same.SOLUTION: The colloidal silica is characterized by being surface modified, having a BET diameter of not larger than 12 nm, and being not substantially agglomerated. The method of producing the colloidal silica is characterized by including a raw material preparation step of supplying easily decomposable organo-silicate to a reaction liquid including a hydrolysis catalyst consisting of an organic amine to make the organo-silicate react with the reaction liquid, to prepare raw material colloidal silica having a BET diameter of not larger than 12 mn, a concentration adjustment step of adjusting the solid content concentration of the raw material colloidal silica to not greater than 13 mass% and adjusting the concentration of the alcohol formed in the raw material preparation step to 1 to 25 mass%, a modification step of modifying the raw material colloidal silica of which concentration has been adjusted, and a concentration step of concentrating the content of residual organic solvent in the colloidal silica which has been modified, to be not greater than 1 mass%.SELECTED DRAWING: Figure 1

The invention provides a preparation method of a surface layer shell for precise casting production of a thick-wall titanium alloy. The preparation method comprises the following steps: S1, preparing a surface layer binder, wherein the surface layer binder comprises modified silica sol, a stabilizer, a reinforcing agent, a wetting agent and an acid-base regulator; the modified silica sol is diluted sodium-stabilized alkaline colloidal silicon dioxide; s2, preparing surface layer refractory powder, wherein the surface layer refractory powder comprises yttrium oxide powder, zirconium oxide powder and calcium fluoride powder; s3, preparing a surface layer coating; adding the surface layer refractory powder in the step S2 into the surface material binder in the step S1; s4, preparation of a surface layer shell, specifically, a module for preparing the surface layer shell enters the surface layer coating in the S3 to be subjected to slurry hanging, sand spraying and drying, and the step is repeated 1-2 times; and S5, the surface layer shell in the step S4 is subjected to firing forming, and the surface layer shell for precise casting production of the thick-wall titanium alloy is obtained. The surface layer shell obtained through the preparation method can be used for producing titanium alloy castings with the wall thickness ranging from 25 mm to 50 mm.

The present application provides a preparation method for a thermally expandable microsphere containing hydrophilic organic-modified colloidal silicon dioxide. In the preparation method, hydrophilic organic-modified colloidal silicon dioxide is mixed with a mixture of a monomer material capable of polymerizing to form a thermoplastic polymer shell and at least one foaming agent to form an emulsion, and the emulsion is polymerized to form the thermally expandable microsphere. Surface-modified colloidal silicon dioxide with hydrophilic organic group in the present application has good salt tolerance stability, can be stabilized in brine and is beneficial to the preparation of the thermally expandable microsphere; and the prepared microsphere has a narrow particle size distribution, can be easily dispersed in water and an organic system, and has good wettability. The application also relates to a thermally expandable microsphere and use thereof.

To provide colloidal silica with few fine particles.SOLUTION: Provided is a method for producing colloidal silica.SELECTED DRAWING: None

The present invention relates generally to methods of producing, using, and storing stable aqueously dispersed superhydrophobic compositions made from these compositions to provide superhydrophobic treatments on a range of porous, semi-porous, and non-porous target materials and surfaces as well as combinations of these materials and surfaces. More particularly, the present invention provides stably dispersed waterborne superhydrophobic compositions comprising colloidal silica or hydrophobically-modified silicon dioxide (i.e., silica) and one or more additional agents and / or compounds. When the compositions of the present invention are applied (e.g., via spray deposition, immersion, liquid application, and the like) to a suitable target material and / or surface the target is imparted with a durable (super)hydrophobic coating.

This application relates to the technical field of pharmaceutical preparations, and specifically discloses a pharmaceutical composition containing ibrutinib and its preparation method. The composition includes the active ingredient ibrutinib, colloidal silicon dioxide, solubilizers, and other excipients such as excipients; its preparation method is: the active ingredient ibrutinib is preferentially mixed with colloidal silicon dioxide and solubilizers, followed by dry granulation, mixing, and capsule filling. The composition of this application can be used for the treatment of diseases such as mantle cell lymphoma (MCL) / chronic lymphocytic leukemia (CLL) / small lymphocytic lymphoma, etc. It can effectively break the insoluble complex salt formed by ibrutinib and solubilizers, and has the advantages of fast dissolution rate and significantly improved bioavailability; in addition, the preparation method of this application has the advantages of good process reproducibility, simple process steps, low production cost, and being suitable for large-scale industrial production.

Provided is a coated article comprising a resinous base, a primer layer disposed on the resinous base, a hardcoat layer disposed on the primer layer, and an optically modified layer formed on a surface-layer portion of the hardcoat layer, wherein the primer layer is a cured coating film formed from a primer composition comprising (A) a vinyl-based (co)polymer and (B) inorganic particles having a given median diameter, the vinyl-based (co)polymer (A) including (A-1) a vinyl-based (co)polymer having an alkoxysilyl group and the primer layer having a thickness of 1-20 µm, and the hardcoat layer is a cured coating film formed from a silicone composition comprising (a) a silicone resin, (b) colloidal silica, and (c) an ultraviolet absorber, the hardcoat layer having a thickness of 1-15 µm.

The invention relates to the technical field of medicines, in particular to an agomelatine pharmaceutical composition as well as a preparation method and application thereof. The agomelatine pharmaceutical composition comprises inner-layer particles, a coating layer and outer-layer auxiliary materials, the inner-layer particles are prepared from the following raw materials: agomelatine, hydroxypropyl methylcellulose, mannitol and colloidal silicon dioxide; the coating layer is obtained by coating a chitosan-sodium carboxymethyl starch suspension on the surfaces of the inner-layer particles; the outer-layer auxiliary material is prepared from the following raw materials: glyceryl behenate, cane sugar, povidone, sodium carboxymethyl starch and magnesium stearate. The agomelatine pharmaceutical composition provided by the invention is stable in dissolution, extremely low in impurity content, controllable in quality and excellent in stability, and can be used for treating depression and related diseases thereof.

A coupling assembly for a motor vehicle powertrain includes a rigid carrier and a wet friction material attached to a surface of the rigid carrier. The wet friction material includes a base material enclosing a fiber matrix and filler particles embedded in the fiber matrix; a binder embedded in the base material; and a colloidal silica coating applied to an outer surface of the base material.

The present invention provides a sulfonic acid-modified colloidal silica which has excellent long-term stability of metal adsorption amount and is capable of suppressing the amount of residual abrasive grains on a polished metal surface after polishing and cleaning.　This sulfonic acid-modified colloidal silica contains silica particles, and is characterized in that: (1) the surfaces of the silica particles are modified with a sulfonic acid group; (2) the Cu ion adsorption amount of the silica particles is 5.00-110.00 µmol / g; (3) the ratio (Cu ion adsorption amount (µmol / g) / S content (µmol / g)) of the Cu ion adsorption amount to the S content of the silica particles is 0.50 or more; and (4) the rate of change over time of the Cu ion adsorption amount of the silica particles is 1.30 or less as measured by the measurement method described below. [Measurement method of the rate of change over time of the Cu ion adsorption amount of the silica particles] The sulfonic acid-modified colloidal silica is left to stand at 25°C for 3 months. The Cu ion adsorption amount (µmol / g) of the silica particles before standing and the Cu ion adsorption amount (µmol / g) of the silica particles after standing are measured and the rate of change over time of the Cu ion adsorption amount of the silica particles is calculated by the following formula. (Rate of change over time of Cu ion adsorption amount of silica particles) = (Cu ion adsorption amount (µmol / g) of silica particles after standing) / (Cu ion adsorption amount (µmol / g) of silica particles before standing)

Chemical mechanical polishing compositions and methods for preventing clogging of polishing pad grooves are disclosed. The chemical mechanical polishing composition comprises water, an abrasive having bimodal distribution of colloidal silica particles, including elongate colloidal silica particles, from 80% to less than or equal to 90% hydrolyzed polyvinyl alcohol, an electrolyte, and a pH greater than 7. The method comprises the following steps: providing a substrate containing silicon oxide; providing the chemical mechanical polishing composition; providing a chemical mechanical polishing pad having a polishing surface and a recess; creating a dynamic contact at an interface between the polishing surface of the chemical mechanical polishing pad and the substrate with a downforce of 20 to 35 kPa; a chemical mechanical polishing composition is dispensed onto a chemical mechanical polishing pad at or near an interface between the chemical mechanical polishing pad and a substrate. The water-based chemical mechanical polishing composition and method inhibit polishing pad recess clogging during chemical mechanical polishing of a semiconductor substrate.

Provided is a method of applying a nano coating to stainless steel including cleaning stainless steel; polishing the stainless steel with a nano abrasive composed of colloidal silica, nano-sized diamond particles, and ethylene glycol; immersing the stainless steel in a pickling solution composed of hydrochloric acid and containing an ionic liquid for 25 seconds; heat treating the surface of the stainless steel; applying a nano-coating agent composed of isopropyl alcohol, methylsilsesquioxane, siloxane, sulfuric acid, and distilled water to the surface of the stainless steel heat treated through the heat treatment step in an amount of 60 mg / m2; curing the nano-coating agent applied on the surface of the stainless steel for 5 minutes; coating the surface of the stainless steel with a chromium mixture; and coating the surface of the stainless steel coated with the chromium mixture through the chromium mixture coating step with a finishing agent.

Provided is a colloidal silica which, when used as an abrasive grain for polishing, hardly leaves silica particles on the polished surface and can form a polished surface with reduced surface roughness. A colloidal silica in which silica particles are dispersed in a solvent, wherein the true specific gravity of the silica particles by the liquid phase substitution method is 1.60 or more and 2.20 or less, and the value of composite parameter 1 calculated by a specific formula is 10 or more and 200 or less.

In the present invention, the amount of an alkoxysilane (for example, the total amount of tetraethyl orthosilicate and an alkoxysilane having an amino group) added in a core-particle shell-forming reaction is 200 times or more by mole relative to the amount of a basic catalyst present in a shell-forming reaction solution. According to the present invention, it is possible to provide a colloidal silica in which a silicon group having an amino group has been introduced into the interior of a particle, the colloidal silica containing core-shell silica particles having a silanol group density of 4.0 particles / nm2 or less, and having a small content of microparticles.

The invention discloses a bisoprolol amlodipine compound tablet and a preparation process thereof, and the preparation method comprises the following steps: mixing bisoprolol or a pharmaceutically acceptable salt thereof with microcrystalline cellulose, carboxymethyl starch sodium, colloidal silicon dioxide and anhydrous citric acid according to a ratio, and carrying out dry granulation to obtain bisoprolol particles; the amlodipine or the pharmaceutically acceptable salt thereof, microcrystalline cellulose, carboxymethyl starch sodium, colloidal silicon dioxide and anhydrous citric acid are subjected to dry granulation in proportion, and amlodipine granules are obtained; the preparation method comprises the following steps: uniformly mixing bisoprolol particles and amlodipine particles, and uniformly mixing with a lubricant to obtain total mixed particles; and tabletting the total mixed particles to obtain the bisoprolol amlodipine compound tablet. According to the process, a relatively complex double-layer tablet process is not adopted, and the two active ingredients can be substantially separated, so that the operation can be effectively simplified, and the stability of the product can be improved.

The invention relates to the technical field of pharmaceutical preparations. Specifically, the invention relates to a sitafloxacin tablet and a preparation method thereof. The sitafloxacin tablet comprises (1) a solid dispersion which comprises (a) an active component which is sitafloxacin sesquihydrate and accounts for 15%-30% of the total weight of the tablet, (b) a solid dispersion carrier which is copovidone and accounts for 45%-65% of the total weight of the tablet, and (c) a stabilizer which is colloidal silicon dioxide and accounts for 0.1%-2.2% of the total weight of the tablet; (2) a filler accounting for 10-40% of the total weight of the tablet; (3) an adhesive accounting for 1%-5% of the total weight of the tablet; (4) a disintegrating agent accounting for 0.5-3% of the total weight of the tablet; and (5) a lubricant accounting for 0.2%-1.0% of the total weight of the tablet.

There is provided a pharmaceutical dosage form that is suitable for peroral administration to the gastrointestinal tract, which dosage form comprises a pharmaceutical composition in the form of a particulate mixture comprising solid particles of N-butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-iso-butylthiophene-2-sulfonamide (C21), or a pharmaceutically-acceptable salt thereof, admixed with a blend of carrier particles with weight- and / or a volume-based mean diameter, and / or a structural / particle density, that is / are similar to the weight- and / or volume-based mean diameter, and / or the structural / particle density, of the solid particles of C21, and a glidant, which composition is contained within a capsule that is suitable for such peroral administration. Preferred carrier particles have a weight- and / or a volume-based mean diameter that is less than about 100 μm. Preferred carrier particle materials include mannitol. Preferred glidants comprise colloidal silica. Such dosage forms find utility in the treatment of lung diseases, such as idiopathic pulmonary fibrosis, sarcoidosis and respiratory virus-induced tissue damage.

The invention discloses a microcapsule antibacterial material and a preparation method thereof, and relates to the technical field of antibacterial materials. The preparation method comprises the following steps: dissolving quaternary ammonium chitosan in deionized water, dispersing nano iron oxide in the solution, carrying out ultrasonic treatment, adding lavender essential oil hybrid modified montmorillonite into the mixture, and stirring to prepare a mixed solution; dissolving sodium tripolyphosphate in deionized water, slowly dropwise adding the mixture until the mixture is stirred, and placing the mixture in a high-magnetic-field constant-humidity constant-temperature box to prepare an initial emulsion; mixing colloidal silicon dioxide with distilled water to prepare a SiO2 solution, adding the SiO2 solution into the initial emulsion, stirring, adding the quaternary ammonium chitosan solution, stirring, filtering, washing, drying to obtain a crude product material, and freeze-drying the crude product material in a freeze-drying machine to obtain the microcapsule antibacterial material.

The invention discloses a mianserin hydrochloride tablet prepared in a wet granulation mode. The mianserin hydrochloride tablet is prepared from mianserin hydrochloride anhydride, calcium hydrogen phosphate, corn starch, hydroxypropyl methylcellulose, colloidal silicon dioxide, magnesium stearate and a film coating agent. According to the mianserin hydrochloride tablet and the preparation method thereof, the stability of the mianserin hydrochloride tablet is improved by using the high-concentration adhesive solution and optimizing the granulation parameter range, the problem that related substances are increased due to crystal transformation of active ingredients in the product preparation process is solved, and the medication safety of patients is better guaranteed.

Provided is a water-based inorganic coating agent capable of forming a coating film having high antifouling properties and excellent abrasion resistance. The aqueous inorganic coating agent includes colloidal silica, at least one of a sodium phosphate compound and a potassium phosphate compound, boric acid, aluminum monophosphate, and water.