97 results about "Carboxymethyl starch" patented technology

The invention discloses a temperature control method and system in a carboxymethyl starch sodium production process, and relates to the technical field of chemical engineering process control, and the method comprises the following steps: dividing the carboxymethyl starch sodium production process, and determining a temperature control target; establishing a temperature-viscosity-time correlation model; key temperature control points are determined, and different temperature control areas in the reaction kettle are subjected to differential regulation and control by adopting a sectional control strategy; when the temperature gradient in the reaction kettle is detected to exceed a set temperature gradient allowable range, cooperatively adjusting the flow and the flow direction of a heating medium in the jacket of the reaction kettle by combining the heat transfer relation of the adjacent temperature control areas; and evaluating the reaction progress by combining a temperature-viscosity-time correlation model, and controlling to switch to the next reaction stage through temperature step conversion. According to the method, the temperature-viscosity-time correlation model is constructed, so that the viscosity abrupt change point is accurately predicted, the limitation of a traditional single-variable linear model is overcome, and the temperature control precision and the process stability are improved.

The invention belongs to the technical field of water purification materials, and particularly relates to a multifunctional water purification gel material and a preparation method thereof. The composite material consists of an outer-layer film, a middle-layer framework and an inner-layer carbon core, the outer-layer film is prepared from the following raw materials: sodium alginate, carboxymethyl starch, NaCl and Tween-20; the middle-layer framework is prepared from the following raw materials: chitosan, modified sodium bentonite and Fe-P nano powder; the inner-layer carbon core is prepared from the following raw materials: rice hull biochar, nano CaCO3, FeCl3. 6H2O and FeSO4. 7H2O. Efficient water purification is achieved through a three-layer synergistic structure, and the outer layer Ca < 2 + > cross-linked sodium alginate / carboxymethyl starch porous membrane intercepts particles and buffers metal ions; the middle layer is integrated with chitosan to chelate heavy metals, CTAB-bentonite electrostatically adsorbs anions and Fe-P nanoparticles to precipitate phosphate / arsenate; and the biochar-Fe3O4 complex on the inner layer provides deep adsorption and catalytic oxidation functions.

The invention relates to absorbable adhesive styptic powder and a preparation method thereof, and the absorbable adhesive styptic powder is characterized in that the absorbable adhesive styptic powder is formed by cross-linking aldehyde polysaccharide and a polyamino compound through Schiff base reaction, the raw materials are selected from at least one of glucan, sodium carboxymethyl cellulose, sodium hyaluronate, chitosan and carboxymethyl starch; the polyamino compound is selected from at least one of polylysine, polypeptide, bovine serum albumin and polyamine; the styptic powder is porous particles with the particle size of 10-1000 meshes, is cured into gel within 10 seconds after being in contact with body fluid, and is completely degraded within 15-60 days. According to the scheme, the styptic powder has the advantages of rapid wet adhesion, controllable degradation and excellent processability, and is an urgent clinical demand.

The invention relates to the technical field of packaging materials, in particular to a preparation method of a food heat-preservation environment-friendly quick-transportation packaging bag. The prepared quick-transportation packaging bag sequentially comprises an outer film layer, a heat preservation layer, an aluminum foil layer and an inner film layer from outside to inside. The outer film layer and the inner film layer are made of a blend of polylactic acid, carboxymethyl starch and glycerol, the thermal insulation layer is formed by compounding a phase change capsule, silicon dioxide aerogel and a polyurethane adhesive on an aluminum foil layer, the phase change capsule takes a mixture of n-octadecane and paraffin as a core material and takes Arabic gum as a wall material, and the outer surface of the wall material is coated with a stearic acid film layer; an antibacterial coating containing microwave modified beewax, a functional additive and 3-aminopropyltriethoxysilane is sprayed on the inner surface of the inner film layer; the prepared quick-transportation packaging bag has excellent heat preservation performance and antibacterial performance, also has good degradability, is environmentally friendly and can meet multiple requirements of modern food logistics for packaging.

The invention provides a natural polymer shear strength improving agent for temperature-resistant tackifying water-based drilling fluid as well as a preparation method and application of the natural polymer shear strength improving agent. The shear strength improving agent is prepared from the following raw materials in parts by mass: 1 to 7 parts of carboxymethyl starch, 1 to 5 parts of 2-acrylamido-2-methylpropanesulfonic acid, 1 to 5 parts of dimethyl diallyl ammonium chloride, 1 to 5 parts of N-vinyl pyrrolidone, 1 to 5 parts of acrylamide, 0.01 to 0.05 part of an initiator I, 0.01 to 0.05 part of an initiator II, 0.01 to 0.07 part of a cross-linking agent epoxy chloropropane, 50 to 70 parts of water and 150 to 220 parts of absolute ethyl alcohol. According to the shear strength improving agent, natural high polymer materials are used, a polymer net structure is formed through polymerization reaction, the cross-linking agent is used for promoting the net structure to be tighter for tackifying, and the shear strength improving agent has better thermal stability, dynamic shear force, flocculation capacity and suspension stability while the cost and the environmental load are reduced.

The invention discloses a bisoprolol amlodipine compound tablet and a preparation process thereof, and the preparation method comprises the following steps: mixing bisoprolol or a pharmaceutically acceptable salt thereof with microcrystalline cellulose, carboxymethyl starch sodium, colloidal silicon dioxide and anhydrous citric acid according to a ratio, and carrying out dry granulation to obtain bisoprolol particles; the amlodipine or the pharmaceutically acceptable salt thereof, microcrystalline cellulose, carboxymethyl starch sodium, colloidal silicon dioxide and anhydrous citric acid are subjected to dry granulation in proportion, and amlodipine granules are obtained; the preparation method comprises the following steps: uniformly mixing bisoprolol particles and amlodipine particles, and uniformly mixing with a lubricant to obtain total mixed particles; and tabletting the total mixed particles to obtain the bisoprolol amlodipine compound tablet. According to the process, a relatively complex double-layer tablet process is not adopted, and the two active ingredients can be substantially separated, so that the operation can be effectively simplified, and the stability of the product can be improved.

Carboxymethyl starch is a gelling or thickening agent for obtaining cosmetic or dermatological compositions with a cushioning effect. However, this starch has the disadvantage of forming fluff when applied to the skin and / or after drying. The present application proposes a solution for reducing the formation of fluff by combining an oil and a selected surfactant.

To provide a novel, non-foaming, tablet-type skin cleanser. [Solution] A tablet-type skin cleansing agent characterized by containing (A) to (C). (A) Bar-shaped crystalline cellulose (B) Anionic surfactants (C) One or more of the following: acrylates crosspolymer-2-Na, carboxymethyl starch sodium.

This invention relates to a rapid-setting high-strength concrete and its preparation method. The rapid-setting high-strength concrete comprises the following raw materials in parts by weight: 100-200 parts cement, 80-100 parts coarse aggregate, 40-60 parts fine aggregate, 10-20 parts rubber powder, 20-30 parts modified straw-based carbon powder, 0.3-0.5 parts coupling agent, and 0.6-0.8 parts water-reducing agent. The modified straw-based carbon powder is obtained by first adding straw powder to an activation solution containing aluminum sulfate, carboxymethyl starch, and triethanolamine, followed by activation, ball milling, and freeze-drying to obtain a precursor. The precursor is then mixed with flake aluminum powder and heated under an inert atmosphere to obtain the final product. The mass fraction of aluminum sulfate is 5-10%, the mass fraction of carboxymethyl starch is 5-10%, and the mass fraction of triethanolamine is 3-5%. This invention improves the rapid setting effect, compressive strength, flexural strength, and crack resistance of concrete by incorporating modified straw-based carbon powder into the concrete components. This is of great significance for improving the overall performance of concrete and developing infrastructure construction.

The application provides a method for preparing composite silicon fertilizer from silicon-rich residue, which is produced in the production process of phosphogypsum; the silicon-rich residue is first washed with water to remove soluble fluorine; then alkaline components such as carbide slag, calcium hydroxide and calcium oxide are added to fix fluorine; after treatment, the silicon-rich residue is mixed with water glass, polyacrylamide, superabsorbent resin, carboxymethyl starch, sodium carboxymethyl cellulose and other adhesives in a certain proportion, and then granulated to prepare granular composite silicon fertilizer; the effective silicon content in the composite silicon fertilizer is more than 25%, the effective phosphorus content is more than 0.2%, the potassium content is more than 0.3% and the composite silicon fertilizer does not contain soluble fluorine; the method realizes the resource utilization of the silicon-rich residue separated from the phosphogypsum, improves the economy of the overall phosphogypsum purification process and is beneficial to the popularization of the phosphogypsum purification process.

The application provides an oral instant tablet containing Morinda citrifolia oil, which comprises the following components in parts by mass: Morinda citrifolia oil microemulsion 10 parts, carrier 30-40 parts, coating material 2-4 parts, and disintegrating agent 2-5 parts. The coating material is selected from Aeroperl and / or Sylysia; the carrier is selected from one or more of microcrystalline cellulose MCC PH101, microcrystalline cellulose MCC PH102, starch and lactose; and the disintegrating agent is selected from carboxymethyl starch sodium and / or low-substituted hydroxypropyl cellulose. The microemulsification technology is used to wrap the essential oil to reduce the volatilization of the essential oil; the microemulsion is made into a tablet to cover the acidity, increase the compliance of the public, and realize the form change of the Morinda citrifolia oil microemulsion from liquid to solid. The application studies and prepares the oral instant tablet containing Morinda citrifolia oil, which not only solves the inherent defects of traditional dosage forms, but also provides a more convenient taking mode compared with common tablets.

The invention provides a preparation method of low-sodium carboxymethyl starch based on pregelatinization-puffing-etherification triple modification, and relates to the technical field of starch deep processing. The starch is used as a raw material, the low-sodium carboxymethyl starch is prepared through pre-gelatinization, preliminary alkalization, low-temperature high-pressure puffing, further alkalization, etherification, neutralization and purification in sequence, the product is high in substitution degree, uniform in distribution, high in purity, good in cold water solubility, high in transparency and stable in viscosity, and the application requirements in medicine and food are met; the application field of the carboxymethyl starch is expanded.

A hydrate decomposition inhibiting composition, a coupling enhanced solid hydrate, and a method for improving the solid hydrate storage and transportation stability relating to the technical field of natural gas safety storage and transportation are provided. The hydrate decomposition inhibiting composition contains a carboxymethyl starch salt and an alkyl glycoside surfactant. The composition improves the interface stability of the hydrate phase boundary and the mechanical stability of the hydrate and enhance the strength of the hydrate crystal interface since the colloidal solution formed by dispersing the sodium carboxymethyl starch and the alkyl glycoside surfactant in water can coat the surface of the hydrate to form a protective layer, thereby improving the structural stability of the hydrate. Therefore, the composition inhibits the decomposition of the hydrate, reduces the decomposition rate of the hydrate, and can further reduce the decomposition amount of the hydrate.

The invention discloses a carboxymethyl starch hydrogel adsorbent capable of efficiently adsorbing methylene blue and a preparation method of the carboxymethyl starch hydrogel adsorbent. The preparation method comprises the following steps: firstly, gelatinizing cassava starch serving as a raw material in an alkaline urea solution at a low temperature, crosslinking by utilizing epoxy chloropropane, and performing freeze thawing treatment to construct a stable three-dimensional network hydrogel skeleton; then, in an ethanol water solution system, carrying out alkalization and etherification reaction on the gel skeleton, and introducing a carboxymethyl group in situ; according to the method, an innovative strategy of first gelation and then carboxymethylation is adopted, through the space confinement effect of a cross-linked network, the technical problem that high-substitution-degree carboxymethyl starch is easy to dissolve is successfully solved, the substitution degree of the prepared adsorbent reaches up to 1.43, and the prepared adsorbent is insoluble in water and has excellent swelling resistance and mechanical strength. The adsorbent is high in methylene blue adsorption capacity, high in adsorption rate and stable in performance within the pH range of 4-11. The method is simple in process, low in cost and easy for large-scale production, and has a wide application prospect in the field of water treatment.

The application belongs to the technical field of polymer composites, and particularly relates to a shuttle-shaped nanocrystal compatibilized modified carboxymethyl starch / polyvinyl alcohol composite material and a preparation method and application thereof. The shuttle-shaped nanocrystal compatibilized modified carboxymethyl starch / polyvinyl alcohol composite material is prepared from the following raw materials: carboxymethyl starch, polyvinyl alcohol and shuttle-shaped nanocrystal. The application further provides a preparation method of the carboxymethyl starch / polyvinyl alcohol composite material. The prepared composite material has excellent compatibility, mechanical strength, toughness, ultraviolet blocking, high-energy blue light blocking, water vapor blocking, antibacterial, ammonia gas response color changing and other performances, and can maintain relatively high visible light transparency. The composite material can be used as an intelligent indicating material and effectively indicates the freshness change of shrimp and other meat food during storage. The composite material preparation process is simple, and has wide application value in the fields of food packaging, intelligent materials, ammonia gas detection, environmental monitoring and safety.

The invention discloses a preparation method for prolonging the validity period of erythromycin ethylsuccinate orally disintegrating tablets. The preparation method comprises the following steps: sequentially putting low-substituted hydroxypropyl cellulose, microcrystalline cellulose, aspartame, carboxymethyl starch sodium and polyvinylpolypyrrolidone into a wet granulation mixer, covering with a cover, starting equipment, carrying out low-speed dry mixing for 3 minutes, slowly adding low-concentration hydroxypropyl methylcellulose slurry from a feed port of a pot cover, and carrying out low-speed wet mixing for 3 minutes; stopping the machine, opening the cover, scraping powder on the inner surface of the pot cover and the periphery of the inner side of the pot by using a clean scraper, adding erythromycin ethylsuccinate raw materials, covering the cover, starting equipment, carrying out low-speed wet mixing for 3 minutes, and carrying out high-speed wet mixing for 2 minutes. By improving the medicine production process, the stability and durability of the medicine are improved, so that the validity period of the medicine is prolonged, and meanwhile, the effectiveness and safety of the medicine can still be kept within the prolonged validity period.

The invention relates to the technical field of nutritional supplement preparations for pets, in particular to a high-activity non-denatured II-type collagen pet joint dispersible tablet and a preparation method thereof. According to the technical scheme, the soft capsule is prepared from the following raw materials in percentage by weight: 4.0%-7.0% of non-modified II type collagen, 4.0%-6.0% of sodium chondroitin sulfate, 4.0%-6.0% of green lip mussel powder, 0.5%-1.5% of sodium hyaluronate, 30%-40% of microcrystalline cellulose, 12%-18% of sodium carboxymethyl starch, 15%-22% of sweet potato starch, 4.0%-6.0% of polyvinylpolypyrrolidone, 6.0%-10.0% of enzymolysis chicken liver powder, 2.0%-4.0% of yeast extract, 1.5%-3.5% of lactose goat milk powder and 0.3%-0.7% of magnesium stearate. A core active component structure is protected by virtue of nano embedding and a whole-course low-temperature process, and a dual joint maintenance path of immunoregulation and nutrition supplement is constructed.

The invention belongs to the technical field of pharmaceutical preparations, and particularly discloses a pharmaceutical composition of eszopiclone and a preparation method of the pharmaceutical composition, and the pharmaceutical composition comprises the following components by weight: 3-5% of eszopiclone; 65-85% of lactose; 5-25% of corn starch; 5-25% of pregelatinized starch; 0.5 to 5% of povidone K30; 0.5-5% of carboxymethyl starch sodium; 0.1-1% of silicon dioxide; and 0.25-5% of magnesium stearate. According to the preparation method provided by the invention, the main drug eszopiclone and lactose are mixed through an equivalent progressive increase method, and then the mixture is mixed with other diluents, disintegrants and adhesives to prepare wet granules, so that non-uniform dispersion of the main drug with a small proportion in the auxiliary materials can be avoided, the content uniformity of the product is ensured, and the problems in the background technology can be effectively solved.

The utility model discloses sodium carboxymethyl starch production equipment, and relates to the technical field of sodium carboxymethyl starch production, the sodium carboxymethyl starch production equipment comprises a mixing drum, the top of the mixing drum is provided with a drum cover, and the mixing drum is internally provided with a mixing component; the stirring assembly comprises a sleeve, the sleeve is rotationally connected into the barrel cover, a round pipe is rotationally connected into the sleeve, an inclined injection pipe is arranged in the middle of the round pipe, injection holes are formed in the surface of the inclined injection pipe, a first stirring rod is arranged on the surface of the round pipe, supports are arranged on the two sides of the sleeve, and scraping plates are arranged at the bottom ends of the supports; a second stirring rod is arranged on the surface of the scraping plate; the stirring device disclosed by the utility model has the beneficial effects that a medicament and an aqueous solution can be directly dispersed to the middle of a material, so that the material, the medicament and the aqueous solution are fully mixed, the stirring efficiency is improved, the material attached to the inner wall of the stirring barrel is conveniently scraped, the phenomenon that the material is attached to the inner wall of the stirring barrel is avoided, and the later maintenance and cleaning are convenient.

The invention relates to a preparation method of a wheat suspended seed coating agent suitable for an arid region, which is characterized by comprising the following steps: adding a dispersing agent and a defoaming agent into water, adding powder, and stirring for 15-40 minutes under the condition that the rotating speed is 800-3000r / min to obtain a suspension; the preparation method comprises the following steps: adding potassium fulvate and carboxymethyl starch into water, and dissolving to obtain a dissolved solution; adding trichoderma harzianum to obtain a suspension containing the trichoderma harzianum or a dissolving solution containing the trichoderma harzianum; and adding the dissolving solution and / or the dissolving solution containing the trichoderma harzianum into the dissolving solution containing the trichoderma harzianum to obtain the wheat suspended seed coating. The wheat seed coating agent prepared by the invention is applied to wheat, and the stress resistance of the wheat can be obviously improved.

The invention discloses a method for preparing glucose from starch, belongs to the technical field of preparing glucose by enzymolysis, and the method comprises the following steps: sizing, ultrasonic treatment, pretreatment, pre-expansion treatment, hydrolysis saccharification, filtration, desalination, concentration, and drying; the method for the pre-expansion treatment is to first add pre-treated gum arabic solution and carboxymethyl starch to the pre-treated starch slurry, stir for 20-30min and mix evenly at a speed of 600-800rpm, then warm up to 58-62°C, and keep 30-40min at this temperature to pre-expand starch particles. The method reduces the production energy consumption of glucose, shortens the production cycle, and improves the glucose yield and glucose value of glucose prepared by raw amylase, the glucose yield is 97.8-98.4%, and the glucose value is 96.2-96.6%.

The present invention aims to provide an intraoral adhesive film that combines adhesive properties and slow dissolution properties in a well-balanced manner. [Solution] The present invention provides an intraoral adhesive film containing (A) ιcarrageenan and (B) κcarrageenan. Preferably the film further contains (C) a water-soluble polymer such as tamarind gum, gum arabic, karaya gum, xanthan gum, gellan gum, tragacanth gum, guar gum, tara gum, locust bean gum, pullulan, gelatin, casein, pectin, agar, glucomannan, galactomannan, starch, carboxymethyl starch, dextrin, alginic acid, alginic acid ester, chitin, chitosan, carboxymethylcellulose, λcarrageenan, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, and ethylcellulose.

The invention discloses a pharmaceutical composition containing alfacalcidol and a preparation method of the pharmaceutical composition. According to the alfacalcidol pharmaceutical composition, mannitol with a specific particle size is adopted as a filling agent, carboxymethyl starch sodium is adopted as an adhesive, poloxamer 188 is adopted as a stabilizer, and one-step granulation is performed in cooperation with a fluidized bed, so that the compliance, safety and effectiveness of medication of patients are improved, and the alfacalcidol pharmaceutical composition which is reliable and stable in quality and extremely small in specification is obtained. The preparation method is convenient, controllable, high in operability, good in reproducibility and suitable for industrialization.

The invention discloses a composite anti-freezing microwave modified polymer dust suppressant and a preparation method and application thereof, and the composite anti-freezing microwave modified polymer dust suppressant is prepared according to the following steps: (1) putting sodium alginate and sodium carboxymethyl starch into a container, heating to uniformly disperse the sodium alginate and the sodium carboxymethyl starch in water, adding a tert-butyl hydroperoxide solution, stirring, adding N, N '-methylene bisacrylamide and acrylamide, and stirring to obtain a mixed solution; putting the container into a microwave reaction kettle, stirring, heating and reacting to obtain a uniform and stable sodium alginate-sodium carboxymethyl starch mixed solution; and (2) cooling the sodium alginate-sodium carboxymethyl starch mixed solution, adding carboxymethyl chitosan and ammonium dodecyl sulfate, fully stirring, adding calcium chloride, and mixing to obtain the product. The wind erosion resistance of the dust suppressant is effectively improved. Good moisturizing effect, anti-freezing property and wettability can be provided. The problem that the dust suppressant cannot have wind erosion resistance, high water-retaining property and anti-freezing property at the same time is solved.

The invention discloses ionic cross-linked starch hemostatic powder and a preparation method and application thereof.The preparation method includes the steps that carboxymethyl starch with the substitution degree not smaller than 0.3 is dissolved in deionized water to be continuously stirred, a metal ion solution is quantitatively and dropwise added into the solution to obtain floccules, the floccules are centrifuged, washed and freeze-dried, and the ionic cross-linked starch hemostatic powder is obtained; the ionic cross-linked starch hemostatic powder is prepared. The preparation process is mild in reaction condition, a chemical cross-linking agent with poor biological safety is not needed, the process is simple and environment-friendly, and large-scale production is easy to realize.

The metallurgical energy-saving composite modified pellet comprises the following raw materials by weight: dolomite powder 35-40 parts, steel slag powder 15-20 parts, sodium carboxymethyl starch 4-8 parts, cellulose ether 2-4 parts, polyacrylamide 3-5 parts and desulfurization ash 3-5 parts. The metallurgical energy-saving composite modified pellet adopts dolomite powder, steel slag powder, carboxymethyl starch and other raw materials, and simultaneously adds modified silicon carbide and bentonite agent to adjust and optimize, realizes coordinated improvement of the strength and desulfurization efficiency of the product through the mutual coordination of the raw materials, and has remarkable effects of corrosion resistance, moisture resistance and stability of the modified pellet.

The purpose of the present invention is to provide an intraoral adhesive film which has a good balance of adhesive properties and sustained-release properties. Specifically, the present invention provides an intraoral adhesive film containing (A) ι carrageenan and (B) κ carrageenan. It is preferable that the film further contain (C) a water soluble polymer such as tamarind gum, gum arabic, karaya gum, xanthan gum, gellan gum, tragacanth gum, guar gum, tara gum, locust bean gum, pullulan, gelatin, casein, pectin, agar, glucomannan, galactomannan, starch, carboxymethyl starch, dextrin, alginic acid, alginic acid ester, chitin, chitosan, carboxymethyl cellulose, λ carrageenan, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, methyl cellulose, or ethyl cellulose.

The present invention relates to a calcium-magnesium-based composite organic binder for pellets and its preparation and use methods. The calcium-magnesium-based composite organic binder for pellets is composed of the following components, measured by dry weight percentage: 97% to 99% converter slag, 0.5% to 2.2% polyethylene oxide, and 0.5% to 2.3% instant carboxymethyl starch. The present invention utilizes converter slag as a calcium-magnesium-containing raw material, adds a polyethylene oxide solution that has not been dehydrated or dried, and an instant carboxymethyl starch solution, and then undergoes microwave heating, stirring, and deep fusion reaction to obtain the calcium-magnesium-based composite organic binder for pellets. This not only achieves efficient and resource-recycling utilization of converter slag, but also helps improve the quality of pellets and reduce production costs for steel enterprises.

The invention relates to the technical field of textile printing and dyeing, in particular to a method for preparing digital printing paste from modified straw cellulose. The modified straw cellulose is used as a core, carboxymethyl cellulose, sodium sulfate, an auxiliary agent S60, hydrophobic filler modified carboxymethyl starch, a complexing agent sodium hexametaphosphate and a biological inhibitor BR are compounded, the formula and the preparation process are optimized, the raw material cost is remarkably reduced by 30% or above, and meanwhile the water holding property, rheological property and dye fixation effect of the paste are improved. The obtained paste is bright in color, soft in hand feeling, clear in outline and high in color fastness, and is particularly suitable for deep color digital printing of cotton fabrics. The method disclosed by the invention is simple and easy to implement, mild in condition and easy for large-scale production, and meets the requirements of the market on the efficient and environment-friendly digital printing paste.

The invention relates to the technical field of pharmaceutical preparations, in particular to a methylprednisolone pulse micro-tablet and a preparation method thereof. The methylprednisolone pulse microtablet comprises a quick release tablet core and a coating layer, the quick-release tablet core comprises methylprednisolone, a filler, an antistatic agent A, an antistatic agent B, an adhesive and a lubricant; the coating layer comprises a coating material and a plasticizer; wherein the antistatic agent A is selected from at least one of a combination of organic acid and bicarbonate or ammonium carbonate; the antistatic agent B is selected from at least one of polyoxyethylene, carbomer, high-expansion type pregelatinized starch, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, croscarmellose sodium and crospovidone. The antistatic agent A and the antistatic agent B have a synergistic effect, so that the electrostatic phenomenon can be effectively reduced, and particle adhesion and microchip agglomeration are avoided.