1404 results about "Aqueous ethanol" patented technology

The invention discloses a method for preparing a medical porous tantalum material. The method comprises the following steps of: mixing a poly ethanol aqueous solution and tantalum powder to obtain slurry, wherein the mass concentration of the poly ethanol aqueous solution is 2 to 8 percent; injecting the slurry into an organic foam by vibrating and pressurizing, wherein the vibrating frequency is 20 to 80 times/min; drying; degreasing; sintering, namely raising temperature to 1,500 to 1,800 DEG C at the speed of 10 to 20 DEG C/min under the vacuum degree of 10<-4> to 10<-3>Pa, preserving heat for 120 to 240 minutes, cooling to 200 to 300 DEG C along with a furnace, raising temperature to 1,500 to 1,800 DEG C at the speed of 10 to 20 DEG C/min again, preserving heat for 180 to 240 minutes, raising temperature to 2,000 to 2,200 DEG C at the speed of 5 to 10 DEG C/min, and preserving heat for 120 to 360 minutes; cooling; and performing thermal treatment, namely raising temperature to 800 to 900 DEG C at the speed of 10 to 20 DEG C/min under the vacuum degree of 10<-4> to 10<-3> Pa, preserving heat for 240 to 480 minutes, cooling to 400 DGE C at the speed of 2 to 5 DGE C/min, preserving heat for 120 to 300 minutes, and cooling to room temperature along with the furnace. The porous tantalum prepared by the method is very suitable to be used for the medical implant material for replacing bearing bone tissues, and biocompatibility and the mechanical property can be guaranteed simultaneously.

A neutraceutical beverage comprising pericarp extract from the Garcinia mangostana L. (mangosteen) plant, and juice from mangosteen fruit pulp, preferably combined with juice from at least one of four other ingredients selected from red grapes, lycium, sea buckthorn, and apple, preferably obtained from powdered extract of mangosteen pericarp and a mixture of fruit concentrate and/or powdered fruit and/or fruit extract In a preferred embodiment the neutraceutical beverage comprises mangosteen pericarp extract and juice from each of mangosteen fruit pulp, red grapes, lycium, sea buckthorn, and apple. The mangosteen pericarp extract can be obtained by a process in which mangosteen pericarp is extracted with ethanol, for example, a 50% ethanol, 50% water solution, and the extract is dried under vacuum. The beverage optionally can include one or more additional fruit juices or concentrates, or fruit or plant extracts, such as concord grape concentrate, blueberry concentrate, red raspberry concentrate, powdered green tea extract, powdered grape seed extract, and powdered grape skin extract.

The invention relates to a tamper-resistant, oral pharmaceutical dosage form comprising a pharmacologically active ingredient having psychotropic action and an ethylene-vinyl acetate (EVA) polymer which provides resistance against solvent extraction, resistance against grinding, and resistance against dose-dumping in aqueous ethanol.

The invention discloses core-shell silicon-containing synergetic flame retardant and a preparation method thereof. The invention is characterized in that non-halogen flame retardant is added into the aqueous liquid of ethanol and the pH value is adjusted to be 8 to 12 by an alkaline liquid under the temperature between 30 and 90 DEG C; a surface active agent and a silicone oxonium compound are added for reacting for 2 to 4 hours, thus obtaining the core-shell silicon-containing synergetic flame retardant which takes the non-halogen flame retardant decorated by the surface active agent as a core and takes the poly- silicone oxonium compound generated by the silicone oxonium compound under an alkaline condition as a shell layer; wherein, the weight ratio of the non-halogen flame retardant to the silicone oxonium compound is 2.3 to 19. The average grain diameter of the obtained product is not remarkably increased; the free fluidity of the grains is good; the shell layer is compact and uniform; the water property is greatly reduced; the high temperature water resistance is remarkably improved; the product can be used as the flame retardant of macromolecular materials like polyolefin, rubber, foaming plastics, and the like. Besides, the product can also be used for the inflaming retarding of paper, wood, fabrics, and the like.

The invention discloses a method for preparing a red algae agar fiber. The method comprises the following steps of: cleaning fresh red algae, removing impurities and air-drying; crushing red algae and removing color; extracting agar polysaccharide with hot water, purifying and drying to obtain agar polysaccharide which is suitable for spinning; preparing an agar polysaccharide spinning solution with a certain concentration, performing wet spinning by using an ethanol aqueous solution or DMF (Dimethyl Formamide) aqueous water as a coagulating bath to obtain spinnable agar fiber; and washing, performing ethanol dehydration and air-drying to obtain a fiber material. The method has the advantage of fully utilizing living marine resources along with low-cost and readily available raw materials; and the obtained agar fiber is a pure natural alginate fiber, has high biocompatibility and biodegradability and can be used for clothing industry and pharmaceutical industry.

The invention relates to a preparation method of a porous scaffold material and discloses a preparation method of a nano-fibrous silk fibroin-based porous scaffold. The preparation method comprises the following steps: blending a silk fibroin solution and a collagen solution under the temperature of 0-20 DEG C, standing to ensure the complete reaction of collagen and silk fibroin and generate nano-fiber; freezing the mixed solution to obtain a freezing body; performing freeze drying treatment on the freezing body to obtain a nano-fibrous porous scaffold material; and placing the nano-fibrous porous scaffold material in a vacuum drier with water and methanol, or an ethanol aqueous solution at the bottom, vacuumizing, and then standing to obtain the water-insoluble nano-fibrous porous scaffold. The obtained porous scaffold has 10-1000 microns of communicated pores. The pore walls consist of 10-100nm of nano-fibers; and the porous scaffold has similar nanoscale structures and micronscalestructures to extracellular matrix, is suitable for the adhesion and growth of cells and has good biocompatibility.

The invention relates to Chinese medicinal composition granules and a preparation method thereof. The Chinese medicinal composition granules comprise the following ruptured powder in part by weight: 3 to 18 parts of American ginseng ruptured powder, 1 to 24 parts of pseudo-ginseng ruptured powder, 6 to 36 parts of dendrobium ruptured powder, and 9 to 45 parts of root of red-rooted salvia ruptured powder, wherein the granularity D90 of the ruptured powder is between 5 and 75 mu m. The invention also provides a method for preparing the Chinese medicinal composition granules. The method comprises the following steps of: uniformly mixing the American ginseng ruptured powder, pseudo-ginseng ruptured powder, dendrobium ruptured powder, and root of red-rooted salvia ruptured powder of which the D90 is between 5 and 75 mu m; preparing a soft material by adopting aqueous ethanol at the concentration of over 20 vol percent; and after granulating by using a granulator with 10 to 30 meshes, drying and finishing the granules to obtain the Chinese medicinal composition granules. The Chinese medicinal composition granules are applied to preventing and regulating human cardiac-cerebral vascular system diseases and sub-health state such as weak immunity and fatigability, have the obvious advantages of high medical effect, high quality uniformity, convenient carrying and administration, safety, reliability, and the like, and can meet the requirement on modern fast-paced lifestyle.

The invention provides a method for preparing ergothioneine. The method takes mushrooms or leftovers as raw materials and comprises the following steps: extracting the raw materials in water or an ethanol water solution with the volume percent concentration of 5 percent to 30 percent at the temperature of 70 DEG C to 95 DEG C; sequentially separating and purifying an extracted product through macroporous resin and polyamide resin; collecting an eluting solution and concentrating to obtain ergothioneine extract. Compared with the prior art, the extract with the ergothioneine content of 20 percent to 98 percent can be obtained and the content is much higher than 1 percent to 5 percent in the prior art. The ergothioneine prepared by the invention can reach requirements of industrialized production and lays a foundation for further development and utilization of the ergothioneine extract.

A tamper-resistant pharmaceutical dosage form comprising a pharmacologically active ingredient embedded in a prolonged release matrix, which comprises a prolonged release matrix material selected from the group consisting of nonionic acrylic polymers and waxy materials and which provides prolonged release of the pharmacologically active ingredient, resistance against solvent extraction, resistance against grinding, and resistance against dose-dumping in aqueous ethanol.

The invention discloses a preparation method of an ethanol-permselective POSS (polyhedral oligomeric silsesquioxanes)/silicone rubber composite membrane and belongs to the technical field of pervaporation membrane separation. A membrane liquid formed by mixing of silicone rubber, POSS, a cross-linking agent, a catalyst and a solvent is prepared; a porous support PVDF (polyvinylidene fluoride) base membrane is coated with the membrane liquid; and the POSS/silicone rubber composite membrane is obtained through deep cross-linking. The obtained POSS/silicone rubber composite membrane has excellent ethanol-permselective performance for ethanol aqueous solutions with low concentration (1wt%-30wt%), and the separation factor alpha obtained is 1.70 and the permeation flux J is 0.15 kg/m2h under the optimum condition for ethanol aqueous solutions with the concentration of 10wt%.

The invention discloses a synthesis and preparation method of fasudil hydrochloride, which comprises the steps of taking 5-isoquinoline sulfoacid as raw material, refluxing in thionyl chloride to obtain 5-isoquinoline sulfonyl chloride hydrochloride, adding dichloromethane after dissolving with ice water, adjusting pH value of the solution to be neutral and performing liquid eparation; washing organic phase with water and edible salt, drying and filtering to obtain dichloromethane solution of 5-isoquinoline sulfonyl chloride; performing reaction of the solution with high purity piperazine in the presence of other alkaline reagents, washing the reaction solution with hydrochloric acid aqueous solution and sodium hydroxide aqueous solution after reaction, and extracting the washing solution respectively with dichloromethane; combining organic phases, washing with water, drying and filtering, and dropwise adding saturated hydrogen chloride ethanol solution to separate out crude product of fasudil hydrochloride; and recrystalizing the crude product with ethanol aqueous solution to obtain fasudil hydrochloride. The method provided by the invention greatly reduces the usage amount of high purity piperazine that is expensive by using deacidifying agents that are low in cost so as to reduce the preparation cost of fasudil hydrochloride effectively.

The invention belongs to a preparation method for preparing a polymer skeleton with the surface coated with HKUST-1 through 3D printing, and an application of a polymer skeleton. The preparation method comprises the following steps: printing the polymer skeleton according to a structure specified in a model file by using a 3D printer, and adding the polymer skeleton into an ethanol water solution containing copper salt and trimesic acid; stirring and dripping triethylamine into the ethanol water solution; drying an obtained product at normal temperature or at 50-80 DEG C; soaking the product in methanol, and during the period, replacing the methanol solvent once every 8 hours; drying at the normal temperature or at 50-80 DEG C. According to the preparation method disclosed by the invention, the reaction conditions in the preparation process are moderate, the synthesis is performed at the normal pressure, no pressure equipment is required, the grain size of crystals which form the HKUST-1 is from 20 nanometers to 5 micrometers, the HKUST-1 is uniformly distributed on the surface of a polymer, and the full coverage rate is basically realized. The prepared polymer skeleton with the surface coated with the HKUST-1 has a remarkable dye adsorption effect, and the adsorption efficiency can be over 90%.

The invention discloses a preparation method of a biodegradable nano-microsphere. The method comprises the following steps: 1, dissolving a biodegradable material into an organic solvent to obtain a solution A; 2, adding an emulsifier solution to the solution A, and carrying out ultrasonic dispersion to obtain an emulsified liquid; 3, carrying out negative pressure distillation on the emulsified liquid and discharging the organic solvent to prepare a suspension liquid; 4, pouring the suspension liquid into ethanol water, washing, standing, participating and filtering to obtain filtrate; and 5, carrying out spray drying on filtrate to obtain the biodegradable nano-microsphere. In addition, the invention further discloses an application of the prepared biodegradable nano-microsphere. The biodegradable nano-microsphere prepared by the invention is milk white, transparent or semi-transparent, tasteless, and uniform and consistent in particle size, and can completely meet the nano-microsphere size requirements for injection and application. The biodegradable nano-microsphere is combined with medical hydrogel, and can respectively play good filling and repairing roles at a short period, a middle period and a long period after being injected into a body.

The invention discloses a method for extracting a maslinic acid and oleanolic acid containing mixture from olea europaea L. pomace. The method comprises the following steps of: extracting an extract from the olea europaea L. pomace in an 80-95wt% (weight percent) ethanol aqueous solution, concentrating the extract, redissolving the extract in a 20-70wt% ethanol aqueous solution, adsorbing by using a macroporous adsorption resin, removing water-soluble impurities by using a water-washing resin column, desorbing by using a desorbing solution, mixing the desorbing solution, recovering the desorbing solution, and drying to obtain a maslinic acid and oleanolic acid containing extract. The mixture extracted from the olea europaea L. pomace contains more than 30% of maslinic acid and more than 23% of oleanolic acid.

The invention relates to an external preparation made from Chinese herbal medicines, specifically to a film-spraying agent for treating acute soft tissue injuries. 1000ml of the film-spraying agent in the invention is composed of the following raw materials: a Chinese herbal extract extracted from 20-60g of rheum officinale, 20-60g of Cacumen Platycladi, 10-30g of Cortex Phellodendri amurensis, 10-30g of Herba Lycopi and 10-30g of mint by ethanol, 2-6g of borneol, 0.4-1.2g of menthol, 2-6g of chlorobutanol, 30-60g of polyvinylpyrrolidone, 1-8g of hydroxypropyl methyl cellulose, and the rest ethanol water with a volume concentration of 30-40%. During application, the film-spraying agent of the invention is directly sprayed on the injured part and can form a film in 8 minutes. With good anti-inflammation, pain easing, stasis removing, acute soft tissue injury improving and microcirculation improving, as well as antibacterium effects, the film-spraying agent provided in the invention has an obvious effect in treating acute soft tissue injuries such as sprains, contusions and other local injuries, and redness, swelling, heat, pain, wound surface infection, as well as other aspects.

The invention discloses a sodium alginate pervaporation hybrid membrane for separating aqueous methanol solution, a preparation method and an application of the sodium alginate pervaporation hybrid membrane. Raw materials of the sodium alginate pervaporation hybrid membrane include sodium alginate and inorganic aid. The preparation method for the sodium alginate pervaporation hybrid membrane includes the following steps: mixing the sodium alginate and the inorganic aid to obtain membrane casting solution; and preparing the sodium alginate pervaporation hybrid membrane for separating the aqueous methanol solution by the aid of a solution casting method. The prepared organic-inorganic hybrid membrane is a highly hydrophilic pervaporation membrane, applicable to dehydrating of organic solvent, has good separation effect compared with other membranes which are difficult to separate the aqueous methanol solution, and meanwhile, has good separation effect for aqueous solutions such as aqueous ethanol solution, aqueous isopropanol solution.

The invention provides a strengthening-toughening modification type nano monofilament silk fiber and a preparation method thereof. The strengthening-toughening modification type nano monofilament silk fiber comprises 0.3-0.4% of oxidized graphene, 0.8-1.2% of nano-titanium dioxide particles, 80-85% of fibroin and the balance other substances. The preparation method particularly includes adding titanium dioxide sol into a fibroin solution with stirring sufficiently, and adding an oxidized graphene solution and a thickener sequentially so as to obtain a spinning solution; disposing the spinning solution into an electrostatic spinning injector and regulating voltage, distance and rotating speed of a receiver which is a rotary sticklike object so as to obtain a primary nano monofilament silk fiber; soaking the primary nano monofilament silk fiber into aqueous ethanol for pre-crystallization, and performing thermal treatment so as to obtain the nano monofilament silk fiber. The preparation method is simple, the nano monofilament silk fiber can be obtained by the rotary sticklike receiver through the electrostatic spinning technology, and the strengthening-toughening modification type nano monofilament silk fiber can be obtained by addition of the nano-particles and the oxidized graphene into the fibroin.

The invention belongs to the technical field of chemical coatings, and in particular, relates to a modified nano titanium dioxide self-cleaning coating and a preparation method thereof. The preparation method comprises the following steps: adding 1.5-3 parts of boron and nitrogen doped and coated nano titanium dioxide into an ethanol aqueous solution, stirring and dispersing, adding 0.5-2.5 parts of an organic silane coupling agent, carrying out stirring and heat preservation reaction, then carrying out suction filtration, drying and grinding to obtain silanized boron and nitrogen doped and coated nano titanium dioxide; dispersing 1.5-3 parts of the silanized boron and nitrogen doped and coated nano titanium dioxide into a mixed solution of 15-25 parts of an acrylate monomer and 0.5-2 parts of a co-emulsifier, stirring, carrying out ultrasonic dispersion, then adding 2-6 parts of an emulsifier and 50-90 parts of deionized water, stirring, carrying out ultrasonic dispersion, adding 0.3-0.6 part of an initiator, and carrying out heat preservation for 3-5 h, to obtain the modified nano titanium dioxide self-cleaning coating. The self-cleaning coating has the advantages of good dispersion of titanium dioxide and strong self-cleaning ability.