708results about "Antinoxious agents" patented technology

The application discloses a cardiovascular maintenance functional wine based on a composite fermentation process and a preparation method thereof. Through synergistic fermentation of rosewood flavones, five-grain nutrients and rhizoma notopterygii blood-activating components, a cardiovascular maintenance wine with multiple effects of blood pressure regulation, microcirculation improvement, nerve protection and anti-inflammation is developed. Process parameters are optimized and designed to ensure efficient reservation and release of active components, and the cardiovascular maintenance wine is suitable for daily auxiliary conditioning of sub-healthy people and cardiovascular risk groups.

This disclosure relates to compositions and methods using genetically modified bacteria that express superoxide dismutase (SOD) and catalase enzymes to reduce oxidative stress in the skin, and can be used for various skin conditions. In some embodiments of this disclosure, the genetically modified bacteria are Gram-positive bacteria, for example, of the genus Corynebacterium.

The present invention discloses compositions and methods comprising enriched bisdemethoxycurcumin (BDMC) present at 20% by weight or greater for use in inhibiting receptor for advanced glycation end products (RAGE) expression in a subject with a chronic inflammatory condition. The composition further comprises beta-amyrin palmitate (BAP). The present invention also discloses the use of the composition in managing a chronic inflammatory condition in a subject.

The present invention provides topical and internal skin preparations containing an extract of soapwort cultivated under artificial light with a specific wavelength range. [Solution] The soapwort of the present invention is cultivated by irradiating it with artificial light having a specific wavelength range, and the extract exhibits excellent collagen production promoting effect, MMP inhibitory effect, hyaluronic acid production promoting effect, cell proliferation promoting effect, and antioxidant effect. Furthermore, topical or internal skin preparations containing these effects are particularly effective and also exhibit excellent safety and stability. The soapwort extract of the present invention can be used not only in the field of beauty, such as preventing skin aging, but also in the field of medicine, such as suppressing functional decline due to aging, and is expected to be applied to cosmetics, foods, quasi-drugs, and pharmaceuticals.

This invention belongs to the field of pharmaceutical formulation technology and provides a vinpocetine suspension and its preparation method. The vinpocetine suspension of this invention comprises the following raw materials in specific mass parts: vinpocetine, a suspending agent, a solubilizer, a stabilizer, and water. The vinpocetine suspension of this invention is suitable for oral administration. The excipients in the suspension include a suspending agent, a solubilizer, and a stabilizer. The solubilizer inhibits the aggregation of vinpocetine nanoparticles and improves the solubility and dispersion uniformity of vinpocetine nanoparticles in water. The suspending agent and stabilizer together construct a spatially stable structure, ensuring the suspension and dispersion of vinpocetine nanoparticles and resisting sedimentation. The suspending agent, solubilizer, and stabilizer work synergistically to achieve nanoscale distribution and uniform dispersion and suspension of vinpocetine, significantly improving the bioavailability of vinpocetine. High-pressure homogenization achieves nanoscale distribution of vinpocetine, with a particle size of 200-300 nm.

The present invention relates to a skin regeneration composition comprising a culture medium of tonsil-derived mesenchymal stem cells, the antioxidant activity of which is enhanced by N-acetylcysteine (NAC), and to a method for preparing the same. According to the culture medium and the preparation method of the present invention, reactive oxygen species (ROS) can be effectively reduced during the culturing of tonsil-derived mesenchymal stem cells, thereby enhancing antioxidant efficacy and enabling the preparation of a composition having excellent skin regeneration effects.

This invention relates to a traditional Chinese medicine composition for improving cancer-related fatigue, its preparation method, and its application. Belonging to the field of traditional Chinese medicine technology, it solves the technical problems of the lack of modern traditional Chinese medicine preparations for cancer-related fatigue and the lack of a systematic explanation of the pharmacological mechanism. The solution is: a traditional Chinese medicine composition for improving cancer-related fatigue, its preparation method, and its application, formulated according to the principles of principal, assistant, adjuvant, and guide herbs. The principal herbs are Astragalus membranaceus and Codonopsis pilosula; the assistant herbs are Angelica sinensis and Rehmannia glutinosa; the adjuvant herbs are Poria cocos, Citrus reticulata peel, and Ophiopogon japonicus; and the guide herb is Glycyrrhiza uralensis. By weight fraction, the principal herb is 10-18 parts, the assistant herbs are 8-14 parts, the adjuvant herbs are 8-14 parts, and the guide herb is 1-3 parts. The preparation method of the traditional Chinese medicine composition for improving cancer-related fatigue includes the following steps: 1) water extraction; 2) concentration; 3) spray drying; 4) sieving and mixing; 5) granulation; and 6) drying and packaging. Compared with the prior art, this invention has the advantages of convenient administration, stable efficacy, and a systematic explanation of the pharmacological mechanism.

The application discloses a new use of Leonurine or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating radiation-induced brain injury, specifically, providing a safe and effective therapeutic drug for iron death, neuroinflammation, neuron damage and lipid metabolism disorder accompanying the radiation-induced brain injury, solving the technical problem of lack of specific treatment means in the prior art, and having a wide clinical application prospect. Experiments adopt a C57BL / c mouse 30 Gy whole brain X-ray radiation model, and results show that Leonurine can significantly improve the body weight decrease and survival rate of the model mice, reduce the serum IL-6 and IFN-alpha levels, inhibit the activation of microglial cells in the cerebral cortex and hippocampus, protect and repair damaged neurons, and improve the ultrastructure of mitochondria and synapses; meanwhile, the expression of GPX4 and SLC7A11 proteins in the brain tissue is up-regulated, the GSH content is increased to inhibit iron death, and the levels of GPE, GPS and GPC related to lipid metabolism are restored.

The application discloses a traditional Chinese medicine composition balm for relieving fatigue and / or anxiety and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine and the technical field of daily chemicals. The effective components of the traditional Chinese medicine composition balm provided by the application include a matrix composed of shea butter, jojoba oil and yellow bee wax, and compound essential oils composed of sweet orange essential oil, magnolia denudata essential oil and rose essential oil. The preparation process comprises the following steps: after the yellow bee wax is heated and melted, the shea butter and the jojoba oil are mixed, the compound essential oils are added after cooling to a specific temperature, and then the mixture is stirred uniformly and filled and solidified. The balm of the application can be effectively absorbed through the skin and the olfactory pathway through the synergistic effect of specific vegetable oils and essential oils and the optimized preparation process, and is suitable for relieving fatigue and anxiety caused by staying up late and the like, and has the beneficial effects of natural formula, convenient use and soothing effect.

The application discloses a novel fullerene hydrogel and a preparation method and application thereof. The fullerene hydrogel is formed by chemical cross-linking of a fullerene derivative shown in formula I and oxidized hyaluronic acid (oxHA). The fullerene-hyaluronic acid hydrogel material provided by the application has a porous framework, a large pore size and a cell loading potential.

The present invention provides a composition that possesses antioxidant activity while having high bioavailability. [Solution] The present invention provides a composition containing 1 to 15% by weight of prolycopene, and a method of using the composition, such as to prevent or treat a condition related to oxidative stress.

The disclosure relates to formulations and methods for the in vitro testing of ocular irritants. It was discovered that adding an antioxidant formulation to in vitro ocular irritation tests, including for example, a biochemical ocular irritation test, a reconstituted human corneal epithelium (RhCE) ocular irritation test and an excised eye depth of injury (Dol) test, substantially reduces the rate of false positives without diminishing test sensitivity, resulting in more accurately predicting ocular irritancy of test substances. More particularly, the disclosed method employs relatively high physiologic concentrations of one or more antioxidants that are normally present in tears. In a variation, much higher concentrations of one or more antioxidants may provide protection against in vivo exposure to ocular irritants.

The present application relates to the field of biological medicine and modernization of traditional Chinese medicine, and particularly relates to a therapeutic target, an inhibitor and a traditional Chinese medicine composition for treating ovarian hypofunction caused by oxidative stress and application thereof. The present application first determines SRC tyrosine kinase as a key drug target for preventing and treating the disease. The application of the SRC tyrosine kinase inhibitor (such as secaitinib) in preparing related drugs is provided, which can alleviate the damage of ovarian granulosa cells by inhibiting the SRC activity, down-regulating the expression of antioxidant enzyme related genes and reducing the level of active oxygen. Meanwhile, the present application provides a traditional Chinese medicine composition composed of mulberry, kudzu root, tuckahoe and medlar. The composition can improve the hormone level, enhance the antioxidant capacity, improve the ovarian function and fertility by inhibiting the SRC tyrosine kinase activity and the SRC-RAF1-MEK-ERK signal pathway. The present application provides a new solution for the targeted treatment of ovarian hypofunction and the modernization of traditional Chinese medicine.

The application relates to the technical field of biomedical materials, in particular to a self-lubricating anti-degradation hydrogel core-shell microsphere, a preparation method and application. The microsphere comprises a core and a shell layer; the core is a gel micro-core formed by photo-crosslinking of a photo-cured monomer; the gel micro-core is loaded with a drug; the shell layer is a lubricating anti-degradation layer formed by photo-crosslinking polymerization of a hydrophilic zwitterionic polymer and polyethylene glycol diacrylate after blending; the particle size of the core is 45-280 mu m, and the thickness of the shell layer is 0.1-20 mu m. The scheme provided in the application can load the drug in the core and provide the lubricating anti-degradation function, solves the problems of insufficient lubrication persistence, high enzymatic degradation sensitivity and uncontrollable drug release in the joint cavity, and has the advantages of long-acting lubrication, anti-degradation and controllable drug slow release.

The application discloses a use of a pharmaceutical composition of a phenolic acid compound and probiotics, and particularly relates to a combination of chlorogenic acid and lactobacillus reuteri. The combination of chlorogenic acid and lactobacillus reuteri can improve glycolipid metabolic disorder, improve cognitive dysfunction, emotional disorder and delay aging, and can be used for preparing a medicine for treating metabolic disorder combined with neuropsychiatric diseases.

The present invention relates to an oral anti-ageing composition comprising a mixture of: - At least one ingredient chosen from the group of niacinamide mononucleotide (NMN), niacinamide riboside (NR) and niacin - Resveratrol and / or pterostilbene - Pomegranate extract and / or - Sulforaphane or a source of sulforaphane; and - Vitamin D.

The application discloses a preparation method of a copper-based metal complex and application of the copper-based metal complex in antioxidation activity, relates to the technical field of functional materials, and has the chemical formula [Cu(H3dhbdc)2(H2O)2], wherein H3dhbdc is deprotonated 2,3-dihydroxyterephthalic acid. The copper-based metal complex has specific crystal structure and spatial structure, high synthesis purity, and good stability, and can be used in antioxidation activity. Under the same condition, the scavenging ability of H4dhbdc and the copper-based metal complex on •OH and O2 •‑ is explored, the copper-based metal complex is equivalent to H4dhbdc in terms of the scavenging effect on •OH free radicals, and is better than H4dhbdc in terms of the scavenging effect on O2 •‑ free radicals, and it is shown that the complex Cu 2+ after complexation not only retains the antioxidation activity of H4dhbdc, but also enhances the enzyme activity of H4dhbdc.

The application belongs to the technical field of cottonseed meal processing and animal feed, and particularly relates to application of enzymatic cottonseed meal in preparation of low-protein daily ration, promotion of animal intestinal development, improvement of animal production performance and improvement of carcass quality, wherein the small peptide content, free amino acid content and antioxidant activity of the enzymatic cottonseed meal are all significantly improved compared with cottonseed meal, the change of protein secondary structure and the significant reduction of relative molecular weight are more conducive to promotion of animal absorption of small molecules, are beneficial to animal intestinal health development, and can effectively improve animal growth performance. The feed prepared by replacing part of the conventional feed with the enzymatic cottonseed meal can still achieve the effects of promoting animal intestinal development and improving animal growth performance under the condition that the crude protein content is reduced by 1% to 2% compared with the basic daily ration or the conventional feed, and the feeding cost is significantly reduced compared with the use of the conventional feed.

The application belongs to the technical field of microbial fermentation, and particularly relates to a fermented lactobacillus mucioparius FJ701 and application of the fermented lactobacillus mucioparius FJ701 in preparation of high-biological-activity angelica fermentation product. The angelica fermentation product prepared by fermentation of the fermented lactobacillus mucioparius FJ701 has high content of dihydroferulic acid, butenyl phthalide, polyphenol and flavone, and in vitro simulation digestion experiments show that the bioavailability of dihydroferulic acid, butenyl phthalide and polyphenol is significantly improved.

The application belongs to the field of food processing and biomedical technology, and discloses a preparation method of a salty taste enhancing peptide-naringenin compound and application of the compound in improving cognitive decline. The compound is prepared by compounding salty taste enhancing peptides from soft-shelled turtle eggs and naringenin at a ratio of 20-150:1 (w:w). The preparation process comprises the following steps: soft-shelled turtle egg enzymolysis, ultrafiltration, freeze-drying to obtain salty taste enhancing peptides, mixing the salty taste enhancing peptides with a naringenin solution, concentration, and freeze-drying. The compound has good stability, salty taste enhancing and antioxidant activities, can reduce the use of salt and maintain salty taste. The compound can improve cognitive decline and anxiety caused by aging and diabetes, improve autonomous activity, memory and social skills, strengthen physical fitness, protect nerve cells and skeletal muscles, maintain brain tissue health, and can be applied to the preparation of related preparations for improving cognitive decline.

The present invention aims to provide a cytoprotective agent against ferroptosis that contains DHMBA as an active ingredient, by verifying the effect of DHMBA in suppressing ferroptotic cell death using DN model mice and human renal tubular cells HK-2, for each useful agent containing DHMBA as an active ingredient. [Solution] The present invention provides a cell agent for ferroptosis that has a cytoprotective effect against ferroptosis, comprising 3,5-dihydroxy-4-methoxybenzyl alcohol as an active ingredient.

The present application relates to the technical field of disease detection, and more particularly to a method for diagnosing and treating early atherosclerotic plaques based on multifunctional nanomaterial CeOx-P@PM, which comprises the following steps: S1: assembling CeOx with a MMP2 specific probe to form a CeOx-P compound; and S2: coating the CeOx-P compound with a biomimetic platelet membrane as a carrier to assemble CeOx-P@PM nanoparticles. The method for diagnosing and treating early atherosclerotic plaques based on multifunctional nanomaterial CeOx-P@PM has the excellent characteristics of efficient ROS removal, high bioavailability, lesion targeting, and dual-mode precise imaging, and will provide great help for the diagnosis and treatment of early atherosclerotic plaques in clinical practice.

The present invention relates to: a water-soluble substituent-based novel compound having high solubility and a method for preparing same. The novel compound having high solubility of the present invention has repeating units represented by chemical formula 1, and has an excellent anti-inflammatory effect and an excellent effect on diseases caused by oxidative stress and neuroinflammatory diseases, and thus is useful as a health food or a pharmaceutical composition. [Chemical formula 1]

The object of this disclosure is to provide an oral composition containing Rhodiola rosea extract with enhanced antioxidant activity. [Solution] By incorporating lutein and / or zeaxanthin into an oral composition containing Rhodiola rosea extract, the antioxidant effect is improved.

Disclosed in the present invention is use of an organometallic macrocyclic compound molecule in the catalytic enhancement of the level of intracellular oxidized coenzyme I and in an anti-aging product. The organometallic macrocyclic compound molecule of the present invention enters a cell and catalyzes the conversion of reduced coenzyme I within the cell into oxidized coenzyme I, thereby enhancing the metabolic activity of the cell and prolonging the lifespan of aging animals. The organometallic macrocyclic compound molecule is applied to oxidized coenzyme I supplements, anti-aging drugs, and health care products. By means of daily oral administration, the organometallic macrocyclic compound molecule can improve the metabolic activity of the aging population, thereby maintaining their physiological health and prolonging their lifespan.

The application belongs to the technical field of biological medicine, and particularly relates to an anti-aging ergothioneine composition for improving mitochondrial function and a preparation method thereof. The composition comprises the following components: ergothioneine, sea hao polysaccharide and entada extract. The ergothioneine has good mitochondrial targeted antioxidant activity, can up-regulate the expression of Sirt1 to activate PGC-1a, and promote mitochondrial biosynthesis; the sea hao polysaccharide is helpful to restore mitochondrial function, promote the generation of mitochondrial high-energy phosphoric compounds, improve cell activity and energy supply for regeneration, and can up-regulate the expression of key genes for mitochondrial biosynthesis and ATP synthase related genes. The entada extract can synergize with the ergothioneine and the sea hao polysaccharide, significantly down-regulate the expression of aging related proteins such as p53, p21 and p16 in cells, simultaneously inhibit the transcription of aging related genes, and has a good protective effect on aging cells.

Provided herein are methods and uses of combination therapies involving a GPRC5D-targeted cell therapy comprising a chimeric antigen receptor (CAR) containing an extracellular antigen binding domain that binds to G Protein-Coupled Receptor Class C Group 5 Member D (GPRC5D) and a combination agent, e.g., a bispecific antibody, for treating a subject having a cancer, such as multiple myeloma, as well as related methods, uses, and articles of manufacture.

The present invention relates to a pharmaceutical composition comprising an aminoaromatic compound and a liver function protecting agent, and uses thereof. Specifically, the aminoaromatic compound is a drug that interacts with various molecular targets to exhibit a therapeutic effect, but may cause a significant increase in liver enzymes (AST and ALT), which may pose a potential risk of hepatotoxicity. By co-administering the compound KDS12025 and a bile acid, it is thus possible in the present invention to effectively control the increase in liver enzyme levels by the aminoaromatic compound according to one embodiment.

This invention belongs to the field of functional food technology, specifically relating to an astaxanthin and collagen complex composition and its preparation method. The composition comprises the following components: 5 to 20 parts of astaxanthin phospholipid composite nanoparticles, 60 to 110 parts of glycosylated collagen peptides, 2 to 6 parts of hyaluronic acid-collagen peptide grafts, and 1 to 3 parts of curcumin-encapsulated components. The preparation method of the composition is as follows: S1, preparing an activated aqueous phase base; S2, sequential mixing and primary stabilization; S3, integrating the encapsulated components and fine homogenization; S4, final blending and degassing; S5, solid particle preparation. This invention, by constructing a synergistic system containing multiple modified functional components such as astaxanthin phospholipid composite nanoparticles and glycosylated collagen peptides, and employing a refined compounding process, effectively improves the physical stability of the product and synergistically enhances the bioavailability of the active ingredients and the overall antioxidant support efficacy.

The invention provides a composition containing a white peony root extract, a Chinese magnoliavine fruit extract, a pomegranate extract and a ginseng extract. The composition or the nutritional supplement and the pharmaceutical composition containing the composition can obviously promote the expression of the individual glycine-N-methyltransferase, so that the composition can be applied to nutritional supplement or pharmaceutical products for resisting aging, fatty liver or liver cancer and the like.