2 results about "Sustained release drug" patented technology

The application provides a modified Zein Pickering emulsion, a preparation method thereof and application of the Pickering emulsion in fresh-keeping of sandgrass at room temperature, and belongs to the technical field of food fresh-keeping. The preparation method comprises the following steps: Zein is added into an alkaline solution for amino treatment, and after high-temperature reaction, the solution is cooled and the pH value of the solution is adjusted. After removing impurities, the solid sample is obtained through freeze-drying; the obtained sample is added into water together with another natural extract for reaction, the solution is transferred after a period of time, and impurities are removed, and then the modified Zein polymer coating is obtained through freeze-drying; the modified Zein material is added into water together with cinnamyl aldehyde, and after emulsification by using an ultrasonic homogenizer, the target Pickering emulsion is obtained. The Pickering emulsion obtained by the application has the advantages of sustained drug release, high external tolerance, anti-freeze-thaw cycle, excellent sterilization performance and outstanding antioxidant performance, and can be applied to fresh-keeping of sandgrass at room temperature.

The present disclosure provides for methods of producing analgesia in a subject. In some cases, methods produce analgesia in a subject undergoing arthroscopic subacromial decompression surgery. The present disclosure also relates to improved sustained release drug delivery systems. In some cases, a composition comprises an active pharmaceutical agent; at least one of sucrose acetate isobutyrate and a polyorthoester; an organic solvent; and 2,6-dimethylaniline, wherein the 2,6-dimethylaniline is present at a level less than 500 ppm. In some cases, a composition comprises bupivacaine N-oxide at a level less than 1 wt %, based on weight of the composition. In some cases, a composition comprises metal present at a level less than 5 ppm. Dosage forms and methods are also provided.