12 results about "Sustained release drug" patented technology

A method for designing and manufacturing a long release capsule for extended delivery of a drug to a patient in an ingestible capsule. The method includes determining a drug volume to be delivered and a drug delivery rate. A buoyancy element is selected based on the drug volume. A release port is selected based on the drug delivery rate and the properties of the drug. The design elements are used to produce a capsule design for an ingestible capsule. The design of the capsule is used to generate manufacturing instructions and produce the capsule.

The application provides a modified Zein Pickering emulsion, a preparation method thereof and application of the Pickering emulsion in fresh-keeping of sandgrass at room temperature, and belongs to the technical field of food fresh-keeping. The preparation method comprises the following steps: Zein is added into an alkaline solution for amino treatment, and after high-temperature reaction, the solution is cooled and the pH value of the solution is adjusted. After removing impurities, the solid sample is obtained through freeze-drying; the obtained sample is added into water together with another natural extract for reaction, the solution is transferred after a period of time, and impurities are removed, and then the modified Zein polymer coating is obtained through freeze-drying; the modified Zein material is added into water together with cinnamyl aldehyde, and after emulsification by using an ultrasonic homogenizer, the target Pickering emulsion is obtained. The Pickering emulsion obtained by the application has the advantages of sustained drug release, high external tolerance, anti-freeze-thaw cycle, excellent sterilization performance and outstanding antioxidant performance, and can be applied to fresh-keeping of sandgrass at room temperature.

The present invention relates to a solid oral pharmaceutical for Tetrahydrocannabinol (API) or any other Cannabinoid (API) with a novel, well defined method to enhance solubility of active pharmaceutical ingredients (API) with low solubility in aqueous media and use those enhanced API in a new approach of preparing modified and / or sustained release pharmaceutical formulation for API which are regularly not suitable for sustained release formulations because of their low solubility. This invention is applicable for small molecule API (molecular weight < 1000) for which the solubility can be enhanced by formation of a e.g., Cyclodextrin Complex regardless which Cyclodextrin or derivate thereof is employed according to the method described in this invention. Tetrahydrocannabinol and other Cannabinoids can be found in a wide range of indications like pain relief, insomnia, anti- depression and others.

The invention belongs to the technical field of biological medicine, and particularly discloses a biomacromolecule slow-release metal-polyphenol compound as well as a preparation method and application thereof. The compound comprises metal ions, aromatic alkyl amine polyphenol and a biological macromolecular active drug, wherein the aromatic alkyl amine polyphenol is a compound with a structural general formula as shown in a formula (I), a formula (II), a formula (III) or a formula (IV) or a pharmaceutically acceptable salt of the compound. The compound is formed by self-assembly of metal ions, polyphenol and active drugs under a water phase condition, efficient entrapment of biological macromolecular drugs can be achieved under a mild condition, the drug loading capacity is 1%-95%, and the entrapment efficiency is 1%-100%. The compound can realize controllable release of the loaded biomacromolecular drug, and presents a long-term and continuous slow-release drug delivery effect, so that the stability and bioavailability of the drug in vivo are effectively improved, the drug delivery frequency and potential adverse reaction are reduced, and the compound has a good application prospect.

Sustained release drug-loaded microparticles, pharmaceutical compositions comprising them, methods of making them, and methods of treatment using them are described.

The present invention relates to sustained release formulations of Potassium chloride crystals having a mesh size ranging from about 60 to 100 mesh, combined with one or more pharmaceutically acceptable excipients, wherein the potassium chloride crystals are coated with a coating solution comprising cellulosic polymer in an amount up to 9% w / w based on the total weight of the granules and to processes for their preparation.

The present disclosure provides for methods of producing analgesia in a subject. In some cases, methods produce analgesia in a subject undergoing arthroscopic subacromial decompression surgery. The present disclosure also relates to improved sustained release drug delivery systems. In some cases, a composition comprises an active pharmaceutical agent; at least one of sucrose acetate isobutyrate and a polyorthoester; an organic solvent; and 2,6-dimethylaniline, wherein the 2,6-dimethylaniline is present at a level less than 500 ppm. In some cases, a composition comprises bupivacaine N-oxide at a level less than 1 wt %, based on weight of the composition. In some cases, a composition comprises metal present at a level less than 5 ppm. Dosage forms and methods are also provided.

The invention relates to the technical field of polymer hydrogel, in particular to a heat-sensitive injectable hydrogel material based on natural polysaccharide Sacran and poloxamer 407 and application of the heat-sensitive injectable hydrogel material in wound treatment. The hydrogel is prepared by a physical blending method, wherein P407 endows the material with excellent thermosensitive gelling property and injectability. The Sacran chain penetrates through a P407 network through physical entanglement and hydrogen-bond interaction to form a stable semi-interpenetrating structure, so that the mechanical strength, the water absorption swelling capacity and the biocompatibility of the hydrogel are enhanced. Furthermore, two medicines of tannic acid and dipotassium glycyrrhizinate are synergistically loaded, so that multiple functions of resisting bacteria, resisting oxidation, resisting inflammation and the like are integrated, and wound healing can be effectively promoted. The hydrogel prepared by the invention not only shows excellent heat sensitivity, mechanical property and cytocompatibility, but also can continuously release drugs, so that the treatment effect is further improved. The preparation process of the hydrogel is simple, convenient, efficient, green and environment-friendly. Wide clinical application prospects are realized in the fields of wound dressings and tissue engineering.

The present invention relates to a solid oral pharmaceutical for Axitinib, Ibrutinib and / or Palbociclib (API) or any other Kinase Inhibitor API with a novel, well defined method to enhance solubility of active pharmaceutical ingredients (API) with low solubility in aqueous media and use those enhanced API in a new approach of preparing modified and / or sustained release pharmaceutical formulation for API which are regularly not suitable for sustained release formulations because of their low solubility. This invention is applicable for small molecule API (molecular weight < 1000) for which the solubility can be enhanced by formation of a e.g., Cyclodextrin Complex regardless which Cyclodextrin or derivate thereof is employed according to the method described in this invention. Axitinib, Ibrutinib and / or Palbociclib and other Kinase Inhibitors can be found for treatment of malign tumor diseases and others.

The invention relates to a pain-relieving nano pasting film with a multi-layer composite structure and a preparation process of the pain-relieving nano pasting film, and belongs to the technical field of pasting film preparation. The genipin, the gelatin and the glutamine transaminase are added in the preparation process, so that the state that the collagen is dissolved when encountering water is changed, and the film achieves a slow-release effect; in addition, non-steroidal anti-inflammatory drugs such as diclofenac sodium or ibuprofen arginine are added, and the analgesic effect of the finished product is increased through synergism of the analgesic effect, the antipyretic effect and the effect of inhibiting synthesis of prostaglandin at the inflammation part. The pain-relieving nano pasting film prepared by the invention is a multi-dimensional three-dimensional film woven by multiple processes, the first layer of film is film cloth formed by modifying collagen through system active components and then spinning, and the pain-relieving nano pasting film not only can quickly transdermally relieve pain, but also can continuously release medicines; the second layer of film is an imitated human body sebum film and can effectively lock medicinal components; the pain-relieving nano pasting film prepared by the preparation process is light, thin and comfortable, is fit and free of burden in use, and does not irritate skin.

The invention relates to the technical field of nano materials applied to biomedicine or cosmetics, in particular to supramolecular nano delivery hydrogel as well as a preparation method and application thereof. The supramolecular nano delivery hydrogel provided by the invention has good pH value stability, excellent biocompatibility and relatively high adaptability while controllably and continuously releasing drugs and adjusting mechanical properties to match surrounding tissues; the problem of toxicity caused by the fact that gel is prepared from polymers in the prior art is solved, modification is not needed, the preparation cost is saved, the drug effect can be assisted to be exerted, and the hydrogel can be applied to delivery of hydrophobic drugs or cosmetic functional raw materials inside and outside a human body. More importantly, the nano-micelle hydrogel system is stable, the pH value can be adjusted to a human skin application range, and the nano-micelle hydrogel can be stably stored for a long time. The preparation method of the supramolecular nano delivery hydrogel is simple, mild in condition, cheap and easily available in raw materials and suitable for large-scale industrial production.

An implant is disclosed for the sustained delivery of a drug. The implant comprises a core comprising at least one drug distributed uniformly in a polymer matrix of a first non-erodible polymer. The i