105 results about "Ibuprofen" patented technology

The present invention relates to solid compositions. The present invention addresses the problem of providing a solid composition containing at least one substance selected from the group consisting of tepiperidine and salts thereof, and at least one substance selected from the group consisting of tranexamic acid and salts thereof, in which the dissolution of tepiperidine is improved. [Solution] A solid composition containing the following components: (A) at least one substance selected from the group consisting of tepiperidine and salts thereof; (B) at least one substance selected from the group consisting of tranexamic acid and salts thereof; and (C) at least one compound selected from the group consisting of ibuprofen and salts thereof, in which the solid composition does not include a solid composition comprising levocetirizine or loratadine.

The invention belongs to the technical field of medicines, and particularly relates to a preparation method of solubilizing type ibuprofen. The preparation method comprises the following steps: heating ibuprofen to a molten state, then pouring the ibuprofen into water, and carrying out intermittent ultrasonic treatment in a cooling process, so as to prepare the solubilizing ibuprofen. The preparation method disclosed by the invention is simple to operate, the required materials are easy to obtain, the cost is relatively low, and the prepared ibuprofen still keeps the original crystal form.

The invention relates to the field of drug detection, in particular to an ibuprofen trace impurity rapid detection method, the detection method adopts an ibuprofen trace impurity rapid detection device, the detection device comprises a hollow base cylinder, and the base cylinder is internally provided with a detection piece for rapidly detecting trace impurities in ibuprofen; according to the invention, an ibuprofen medicament is mixed with a solvent, impurities and an ibuprofen main body are rapidly separated, complex pretreatment is not needed, two times of ultraviolet detection comparison of a detection cavity and an analysis cavity or gradual screening detection of a plurality of sorting plates are combined, whether the impurities exist or not and whether the content is qualified or not can be rapidly judged, the detection period is greatly shortened, and the detection efficiency is improved. In addition, the use requirements on detection equipment and operators are effectively reduced, and the rapid and convenient detection effect is achieved.

The application belongs to the technical field of rice cultivation, and particularly relates to application of a jasmonic acid synthesis inhibitor in promoting growth and development of rice. The application finds that the jasmonic acid synthesis inhibitor can promote growth and development of rice, and specifically promotes growth and development of the aboveground part of rice and / or promotes growth and development of the root system of rice. The results of examples show that the jasmonic acid synthesis inhibitor, especially ibuprofen or copper reagent, can significantly increase the fresh weight of the aboveground part of rice, the root length and the fresh weight of the root, and the promoting effect of ibuprofen is superior to that of the copper reagent.

This invention provides a novel method for producing crystals composed of ibuprofen and tranexamic acid. [Solution] A method for producing crystals comprising ibuprofen and tranexamic acid, comprising: (1) adding a mixed powder of ibuprofen and tranexamic acid to an aqueous solution containing 65 w / w% or more and less than 100 w / w% ethanol, or adding the aqueous solution to the mixed powder to obtain a mixture in which the ratio of the content of the aqueous solution to the total mass of ibuprofen and tranexamic acid is 0.09 mL / g or more; and (2) generating the crystals from the obtained mixture.

The invention provides an efficient marine ibuprofen degradation method based on an algae-bacterium co-culture system. In the algae-bacterium co-culture system, the bacterium is a bacillus strain Cytobacillus firus, and the algae is a cocoon-type algae acl-Entomonis Sp. The invention also discloses a preparation method of the algae-bacterium co-culture system. The method comprises the following steps: inoculating an algae-bacterium co-culture system into artificial simulated marine sewage containing ibuprofen, and fully mixing to obtain a mixed solution; and then culturing under proper culture conditions. The removal rate of ibuprofen within 10 days reaches 80.6%, and the method has the advantages of being low in energy consumption, environmentally friendly and suitable for marine pharmaceutical pollution remediation, and is a green biological technical scheme which is driven by solar energy and is ecologically sustainable.

Described are synthetic compounds having anti-inflammatory properties and optionally analgesic properties. These compounds are derivatives of FDA-approved anti-inflammatory, such as ibuprofen and indomethacin, and can be formed using reactions under microwave irradiation. Generally, the compounds contains a moiety of the parent drug, a triazolyl heterocycle, and a substituted or unsubstituted aryl group. In some forms, the compounds show anti-inflammatory properties and optionally analgesic properties with similar or higher efficiencies compared with their respective parent drugs, with additional advantages including no or reduced adverse effects (e.g., without ulcerogenic liability in the gastric) and / or selective inhibition of COX-2 over COX-1. Pharmaceutical compositions suitable for the delivery of the compounds to a subject in need thereof are disclosed. The pharmaceutical formulation can be administered by oral administration, parenteral administration, inhalation, mucosal administration, or a combination thereof. Methods for preventing or treating an inflammatory disease or disorder in a subject are also disclosed.

The present invention provides a solid composition containing: crystals composed of ibuprofen and tranexamic acid; and a surfactant.

This invention provides a drug for antagonizing bacterial endotoxins, its preparation method, and its application, belonging to the biomedical field. The composition consists of 25-55 parts of dried powdered traditional Chinese medicine extract, 25-70 parts of mixed essential oil powder, and 40-90 parts of lentinan powder. The traditional Chinese medicine extract is prepared by decoction of Scutellaria baicalensis, Lonicera japonica, Forsythia suspensa, and Isatis indigotica under reduced pressure at low temperature and spray drying. The mixed essential oil powder is prepared by encapsulating peppermint oil and eucalyptus oil with gelatin and hydroxypropyl cellulose and then spray drying under high pressure. This invention, through specific formulation and processing, significantly enhances the synergistic antagonistic effect of each component against endotoxins. Experiments show that this composition exhibits antagonistic activity far superior to ibuprofen in vitro; in vivo, it significantly reduces the endotoxin content in the plasma of 817 broiler chickens, rapidly alleviates LPS-induced fever and diarrhea, and improves decreased growth performance. Therefore, this invention is of great significance for reducing antibiotic dependence and improving the efficiency of livestock and poultry farming.

1. The name of the designed product: packing box (ibuprofen sustained-release capsule). 2. The use of the designed product: the designed product is used for medicine packing. 3. The design points of the designed product: the combination of shape, pattern and color. 4. The picture or photo that best shows the design points: perspective view. 5. The design contains color.

The invention discloses an ibuprofen composition suspension and a preparation method thereof, the preparation method comprises the following steps: adding purified water accounting for 60% of the prescription dosage into a liquid preparation tank, slowly adding pregelatinized starch in a stirring state, and stirring for more than or equal to 10 minutes after the addition is finished; heating is started, so that the pregelatinized starch is gelatinized; adding a prescription amount of cane sugar into the liquid preparation tank, and stirring for 10 minutes to completely dissolve the cane sugar; starting a tank body for cooling, when the temperature of the liquid medicine is cooled to be less than or equal to 50 DEG C, slowly adding xanthan gum into the stirring tank through a 40-mesh screen under a stirring state, after the xanthan gum is added, continuously stirring for more than or equal to 30 minutes, starting self-circulation to pass through a 5mm screen for 30 minutes, and then replacing a 20-mesh screen to continuously and circularly stir; the xanthan gum and the raw material medicine are added into the stirring tank in a sieving mode, then the liquid medicine is subjected to continuous circulating sieving to ensure that the xanthan gum is completely swelled and the raw material medicine is uniformly dispersed, finally, the content uniformity RSD% of the liquid medicine at different positions is within 2%, and the uniformity of the liquid medicine is good; the feeding process is simplified to a certain extent, the use of equipment is reduced, the cleanness is realized, and the production efficiency is improved.

To provide a method for producing a novel solid composition. [Solution] The present invention provides a method for producing a solid composition, comprising the step of contacting (A) a crystal consisting of ibuprofen and tranexamic acid with (B) licorice.

The invention relates to an ibuprofen-containing transdermal patch as well as a preparation method and application thereof. The ibuprofen-containing transdermal patch comprises a polymer matrix layer, the polymer matrix layer comprises ibuprofen, a compound at least containing one amino group and a pressure-sensitive adhesive, and based on the weight of the polymer matrix layer, the ibuprofen accounts for 10-30% by weight, the compound at least containing one amino group accounts for 0.1-5% by weight, and the pressure-sensitive adhesive accounts for 0.1-5% by weight. The weight content of the pressure-sensitive adhesive is 45%-84%, the pressure-sensitive adhesive is composed of a silicone pressure-sensitive adhesive and an acrylate pressure-sensitive adhesive, and the weight ratio of the silicone pressure-sensitive adhesive to the acrylate pressure-sensitive adhesive is 1: 1-15: 1. According to the transdermal patch, the penetration capacity of ibuprofen is remarkably improved, particularly, the early-stage medicine penetration rate is higher, the medicine utilization rate is greatly improved, meanwhile, the patch is good in application performance, free of skin irritation, free of crystallization in the long-term storage process, good in stability and capable of better meeting the clinical medication requirement.

The invention discloses a zinc porphyrin modified electrode, a preparation method of the zinc porphyrin modified electrode and application of the zinc porphyrin modified electrode in synthesis of ibuprofen from CO2 and aryl halide through electro-catalysis. According to the invention, a zinc porphyrin polymer is immobilized on carbon cloth through pre-assembly and electropolymerization, and a novel zinc porphyrin modified electrode (Zn-TPP-CC) is developed. The electrode shows excellent catalytic performance, and the ibuprofen yield is as high as 96%. Experiments show that the Zn-TPP-CC cathode effectively catalyzes an electrocarboxylation reaction and promotes the generation of alkyl radicals by forming a stable Zn-Cl intermediate, and the process is crucial to subsequent CO2 insertion, so that the total energy barrier of the reaction is remarkably reduced. Evaluation shows that 0.213 kg of CO2 can be fixed when 1 kg of ibuprofen is produced in the process, and compared with a traditional method, carbon emission is reduced by 70.1%. According to the invention, a new view angle is provided for CO2 recycling and green drug synthesis, and the potential of multiphase electro-catalysis in efficient utilization of carbon resources is manifested.

The application relates to a preparation method and application of chiral two-dimensional cadmium sulfide nanosheets. The application aims to solve the problem that it is difficult to construct non-layered chiral two-dimensional inorganic nanomaterials. The method comprises the following steps: placing a first open reaction container and a second open reaction container in a sealable container, adding a cadmium acetate solution into the first open reaction container, then adding a left-rotational ibuprofen / chloroform solution drop by drop, adding a sodium sulfide aqueous solution into the second open reaction container, then adding a hydrochloric acid solution drop by drop, and finally sealing and standing. The application is used for preparing a circularly polarized light detection device for detecting left-rotational / right-rotational circularly polarized light. The application is used for the preparation and application of chiral two-dimensional cadmium sulfide nanosheets.

The invention relates to the technical field of medicines, and discloses a novel light cuspidine type diterpenoid alkaloid compound and application of the novel light cuspidine type diterpenoid alkaloid compound. According to the present invention, the novel C20 selaginine type diterpenoid alkaloids such as the Carmaloidline C, the Carmaloidline D and the Aconialoidline C, which are provided by the present invention, all have significant analgesic effects; wherein the analgesic activity of the Carmaloidline C is the strongest, is superior to that of the positive drug morphine and is obviously superior to that of the positive drug ibuprofen, and the analgesic activity of the Carmaloidline D and the analgesic activity of the Aponiloidline C are superior to that of the positive drug ibuprofen. The medicines can be used for developing analgesic medicines for various acute or chronic pains.

A pharmaceutical composition for intranasal administration and manufacturing method of preparations containing a combination of ibuprofen and ketoprofen at a fraction of the dose required when the same active ingredients are administered orally, useful in the treatment of migraine and other forms of headache.

The present invention relates to solid compositions. The present invention addresses the problem of providing a solid composition containing ibuprofen in which changes in properties are suppressed. [Solution] A solid composition comprising the following components: (A) ibuprofen; (B) at least one substance selected from the group consisting of tepiperidine and salts thereof; and (C) at least one compound selected from the group consisting of tranexamic acid and salts thereof, in which the solid composition does not include a solid composition containing levocetirizine or loratadine.

The present invention relates to solid compositions. The present invention addresses the problem of providing a novel solid composition. The solution of the invention is to provide a solid composition containing crystals formed by ibuprofen and tranexamic acid, and licorice.

The application discloses a preparation method of a 3D printing anti-inflammatory biodegradable airway stent, and provides a new solution for rapidly preparing a personalized biodegradable airway stent for clinical application. The preparation method comprises the following steps: preparing a customized airway stent by using a 3D printing technology; obtaining an amine crosslinked stent by using a surface modification method; and further obtaining an anti-inflammatory airway stent by using an amidation reaction between ibuprofen and the surface amino group. The process has good repeatability and excellent personalized customization performance, and can be used as an effective means for treating central airway obstruction.

This invention relates to the fields of environmental and chemical technology, specifically to a nitrogen-modified activated carbon adsorbent material, its preparation method, and its applications. The invention employs an ammonium chloride solution impregnation method combined with high-temperature activation under a nitrogen inert atmosphere to modify the surface of pretreated granular activated carbon, increasing the content of basic groups on the activated carbon surface, thus preparing a nitrogen-modified activated carbon adsorbent material. Experimental results show that the prepared nitrogen-modified activated carbon exhibits high adsorption efficiency for carboxylic acid drug pollutants such as naproxen, ibuprofen, and diclofenac. The preparation conditions of this invention are mild, the operation steps are simple, the required reagents are inexpensive, and the safety is relatively high, making it suitable for the treatment of drinking water, sewage, and medical wastewater.

The invention discloses an ibuprofen continuous flow recrystallization method. The method comprises the following steps: preheating an ibuprofen saturated solution, and pumping the preheated ibuprofen saturated solution into a micro-channel crystallizer; cooling the material in the micro-channel crystallizer to preliminarily generate a crystal nucleus; collecting the material which preliminarily generates the crystal nucleus, performing temperature-controlled stirring under ultrasonic treatment to complete a crystallization process, and performing purification treatment to obtain an ibuprofen crystal; segmented control is performed on the crystallization process, crystal nucleuses are preliminarily formed in the micro-channel crystallizer to avoid pipeline blockage, and then the crystallization growth process is completed in an ultrasonic oscillation state; the pipeline is prevented from being blocked under the condition that the large-flow stable operation of 100-200 ml / min is achieved, and the accurate control of the crystal size and the high yield are realized; the single-time continuous production time is longer than or equal to 30 min, and the blocking frequency is smaller than or equal to one time per batch; the grain size of the crystal is accurately controlled under large flow, D90 is smaller than or equal to 20 microns, the grain size distribution span (D90-D10) / D50 is smaller than or equal to 10, large flow and high yield are both considered, the refining yield is larger than or equal to 88%, and the treatment capacity per unit time is increased by more than three times compared with that of a traditional low-flow process.

The application provides a ibuprofen suppository, a preparation method and application thereof, and belongs to the technical field of medicines. The application overcomes the defects of slow effect, easy leakage and low bioavailability of traditional suppositories. The suppository is a hollow suppository, which comprises a shell layer and content filled in a hollow cavity of the shell layer; the shell layer is composed of a water-soluble base and a bioadhesive material, the water-soluble base is a mixture of PEG 400 and PEG 1000 ; the content contains ibuprofen active ingredients and an absorption promoter; the content is in the form of a solid powder, when the suppository enters the rectum, the shell layer dissolves and adheres to the rectal mucosa, and the content is directly exposed to the rectal body fluid in the form of a solid powder and is quickly dissolved. The application is particularly suitable for children's antipyretic and analgesic drug preparation, and has the advantages of rapid effect, accurate dosage and good compliance.

This invention relates to the use of ingredients comprising paracetamol, ibuprofen, and any one or both of antihistamine and guaifenesin (or a pharmaceutically acceptable salt, metabolite, or enantiomer of any mentioned aforesaid) in the production of a medication for the treatment of any one or more of mucosal congestion, coughing, fever, sinus secretions, muscle ache, malaise, cold, flu and headache in a human.

The invention describes in certain embodiments a soft gel capsule including a filler material including ibuprofen or a pharmaceutically acceptable salt thereof, and a shell composition comprising a non-gelatinous bio-based polymer, the film dissolving completely in less than 30 minutes when subjected to dissolution with a USP Apparatus I at 75-200 rpm basket speed or a USP Apparatus II with paddle speed at 75 RPM in 900 ml of 50 mM phosphate buffer (pH 7.2) and deionized water at 37 degrees C.

The present invention relates to a pharmaceutical composition comprising ibuprofen or a pharmaceutically acceptable derivative thereof and one or more solubilizers in the form: A) an aqueous solution for intravenous administration comprising a sodium salt or lysine salt of ibuprofen, acetaminophen and preferably one or more cyclodextrins; or B) an aqueous solution for intravenous administration wherein the one or more solubilizing agents are one or more essential amino acids and optionally one or more cyclodextrins; or C) a composition for oral administration comprising acetaminophen and cyclodextrin wherein the composition is in the form of i) an effervescent tablet or effervescent granule, or ii) an oral suspension or syrup or oral solution, or iii) a soft capsule.

This invention provides a novel method for producing crystals composed of ibuprofen and tranexamic acid. [Solution] A method for producing crystals consisting of ibuprofen and tranexamic acid, (1 ) An aqueous solution containing ethanol at a concentration of 65 w / w% or more and less than 100 w / w%, containing ibuprofen and Add a mixed powder of ibuprofen and tranexamic acid, or add the aqueous solution to the mixed powder, The ratio of the content of the aqueous solution to the total mass of fen and tranexamic acid is 0.09 mL. (1) To obtain a mixture that is 1 / g or more, and (2) To produce the crystals from the obtained mixture. A manufacturing method that includes [the ingredient].

Providing a solid composition. [Solution] The present invention provides a solid composition comprising crystals composed of ibuprofen and tranexamic acid, and a surfactant.

The invention relates to a method for providing a water-soluble adduct and an ibuprofen adduct, wherein the membrane permeability of the adduct is improved and the classification according to the Biopharmaceutics Classification System is influenced.

The present invention relates to a solid composition, an ibuprofen slow release improving agent, and a method for improving slow release of ibuprofen. The present invention addresses the problem of providing a solid composition containing ibuprofen and tranexamic acid, the dissolution persistence of which is improved. [Solution] A solid composition containing (A) ibuprofen, (B) at least one substance selected from the group consisting of dextromethorphan and salts thereof, and (C) tranexamic acid.