133 results about "Ibuprofen" patented technology

The present invention relates to solid compositions. The present invention addresses the problem of providing a solid composition containing at least one substance selected from the group consisting of tepiperidine and salts thereof, and at least one substance selected from the group consisting of tranexamic acid and salts thereof, in which the dissolution of tepiperidine is improved. [Solution] A solid composition containing the following components: (A) at least one substance selected from the group consisting of tepiperidine and salts thereof; (B) at least one substance selected from the group consisting of tranexamic acid and salts thereof; and (C) at least one compound selected from the group consisting of ibuprofen and salts thereof, in which the solid composition does not include a solid composition comprising levocetirizine or loratadine.

The invention belongs to the technical field of medicines, and particularly relates to a preparation method of solubilizing type ibuprofen. The preparation method comprises the following steps: heating ibuprofen to a molten state, then pouring the ibuprofen into water, and carrying out intermittent ultrasonic treatment in a cooling process, so as to prepare the solubilizing ibuprofen. The preparation method disclosed by the invention is simple to operate, the required materials are easy to obtain, the cost is relatively low, and the prepared ibuprofen still keeps the original crystal form.

A chemical composition for an oral pharmaceutical product is described having a therapeutically effective amount of one or more active pharmaceutical ingredients (API) including ibuprofen in combination with a cannabidiol (CBD) isolate.

The invention relates to the field of drug detection, in particular to an ibuprofen trace impurity rapid detection method, the detection method adopts an ibuprofen trace impurity rapid detection device, the detection device comprises a hollow base cylinder, and the base cylinder is internally provided with a detection piece for rapidly detecting trace impurities in ibuprofen; according to the invention, an ibuprofen medicament is mixed with a solvent, impurities and an ibuprofen main body are rapidly separated, complex pretreatment is not needed, two times of ultraviolet detection comparison of a detection cavity and an analysis cavity or gradual screening detection of a plurality of sorting plates are combined, whether the impurities exist or not and whether the content is qualified or not can be rapidly judged, the detection period is greatly shortened, and the detection efficiency is improved. In addition, the use requirements on detection equipment and operators are effectively reduced, and the rapid and convenient detection effect is achieved.

The application belongs to the technical field of rice cultivation, and particularly relates to application of a jasmonic acid synthesis inhibitor in promoting growth and development of rice. The application finds that the jasmonic acid synthesis inhibitor can promote growth and development of rice, and specifically promotes growth and development of the aboveground part of rice and / or promotes growth and development of the root system of rice. The results of examples show that the jasmonic acid synthesis inhibitor, especially ibuprofen or copper reagent, can significantly increase the fresh weight of the aboveground part of rice, the root length and the fresh weight of the root, and the promoting effect of ibuprofen is superior to that of the copper reagent.

This invention provides a novel method for producing crystals composed of ibuprofen and tranexamic acid. [Solution] A method for producing crystals comprising ibuprofen and tranexamic acid, comprising: (1) adding a mixed powder of ibuprofen and tranexamic acid to an aqueous solution containing 65 w / w% or more and less than 100 w / w% ethanol, or adding the aqueous solution to the mixed powder to obtain a mixture in which the ratio of the content of the aqueous solution to the total mass of ibuprofen and tranexamic acid is 0.09 mL / g or more; and (2) generating the crystals from the obtained mixture.

The invention provides an efficient marine ibuprofen degradation method based on an algae-bacterium co-culture system. In the algae-bacterium co-culture system, the bacterium is a bacillus strain Cytobacillus firus, and the algae is a cocoon-type algae acl-Entomonis Sp. The invention also discloses a preparation method of the algae-bacterium co-culture system. The method comprises the following steps: inoculating an algae-bacterium co-culture system into artificial simulated marine sewage containing ibuprofen, and fully mixing to obtain a mixed solution; and then culturing under proper culture conditions. The removal rate of ibuprofen within 10 days reaches 80.6%, and the method has the advantages of being low in energy consumption, environmentally friendly and suitable for marine pharmaceutical pollution remediation, and is a green biological technical scheme which is driven by solar energy and is ecologically sustainable.

A chemical composition for an oral pharmaceutical product is described having a therapeutically effective amount of one or more active pharmaceutical ingredients (API) including acetaminophen and ibuprofen in combination with a cannabidiol (CBD) isolate.

Described are synthetic compounds having anti-inflammatory properties and optionally analgesic properties. These compounds are derivatives of FDA-approved anti-inflammatory, such as ibuprofen and indomethacin, and can be formed using reactions under microwave irradiation. Generally, the compounds contains a moiety of the parent drug, a triazolyl heterocycle, and a substituted or unsubstituted aryl group. In some forms, the compounds show anti-inflammatory properties and optionally analgesic properties with similar or higher efficiencies compared with their respective parent drugs, with additional advantages including no or reduced adverse effects (e.g., without ulcerogenic liability in the gastric) and / or selective inhibition of COX-2 over COX-1. Pharmaceutical compositions suitable for the delivery of the compounds to a subject in need thereof are disclosed. The pharmaceutical formulation can be administered by oral administration, parenteral administration, inhalation, mucosal administration, or a combination thereof. Methods for preventing or treating an inflammatory disease or disorder in a subject are also disclosed.

The present invention provides a solid composition containing: crystals composed of ibuprofen and tranexamic acid; and a surfactant.

This invention provides a drug for antagonizing bacterial endotoxins, its preparation method, and its application, belonging to the biomedical field. The composition consists of 25-55 parts of dried powdered traditional Chinese medicine extract, 25-70 parts of mixed essential oil powder, and 40-90 parts of lentinan powder. The traditional Chinese medicine extract is prepared by decoction of Scutellaria baicalensis, Lonicera japonica, Forsythia suspensa, and Isatis indigotica under reduced pressure at low temperature and spray drying. The mixed essential oil powder is prepared by encapsulating peppermint oil and eucalyptus oil with gelatin and hydroxypropyl cellulose and then spray drying under high pressure. This invention, through specific formulation and processing, significantly enhances the synergistic antagonistic effect of each component against endotoxins. Experiments show that this composition exhibits antagonistic activity far superior to ibuprofen in vitro; in vivo, it significantly reduces the endotoxin content in the plasma of 817 broiler chickens, rapidly alleviates LPS-induced fever and diarrhea, and improves decreased growth performance. Therefore, this invention is of great significance for reducing antibiotic dependence and improving the efficiency of livestock and poultry farming.

1. The name of the designed product: packing box (ibuprofen sustained-release capsule). 2. The use of the designed product: the designed product is used for medicine packing. 3. The design points of the designed product: the combination of shape, pattern and color. 4. The picture or photo that best shows the design points: perspective view. 5. The design contains color.

The invention discloses an ibuprofen composition suspension and a preparation method thereof, the preparation method comprises the following steps: adding purified water accounting for 60% of the prescription dosage into a liquid preparation tank, slowly adding pregelatinized starch in a stirring state, and stirring for more than or equal to 10 minutes after the addition is finished; heating is started, so that the pregelatinized starch is gelatinized; adding a prescription amount of cane sugar into the liquid preparation tank, and stirring for 10 minutes to completely dissolve the cane sugar; starting a tank body for cooling, when the temperature of the liquid medicine is cooled to be less than or equal to 50 DEG C, slowly adding xanthan gum into the stirring tank through a 40-mesh screen under a stirring state, after the xanthan gum is added, continuously stirring for more than or equal to 30 minutes, starting self-circulation to pass through a 5mm screen for 30 minutes, and then replacing a 20-mesh screen to continuously and circularly stir; the xanthan gum and the raw material medicine are added into the stirring tank in a sieving mode, then the liquid medicine is subjected to continuous circulating sieving to ensure that the xanthan gum is completely swelled and the raw material medicine is uniformly dispersed, finally, the content uniformity RSD% of the liquid medicine at different positions is within 2%, and the uniformity of the liquid medicine is good; the feeding process is simplified to a certain extent, the use of equipment is reduced, the cleanness is realized, and the production efficiency is improved.

To provide a method for producing a novel solid composition. [Solution] The present invention provides a method for producing a solid composition, comprising the step of contacting (A) a crystal consisting of ibuprofen and tranexamic acid with (B) licorice.

The invention relates to an ibuprofen-containing transdermal patch as well as a preparation method and application thereof. The ibuprofen-containing transdermal patch comprises a polymer matrix layer, the polymer matrix layer comprises ibuprofen, a compound at least containing one amino group and a pressure-sensitive adhesive, and based on the weight of the polymer matrix layer, the ibuprofen accounts for 10-30% by weight, the compound at least containing one amino group accounts for 0.1-5% by weight, and the pressure-sensitive adhesive accounts for 0.1-5% by weight. The weight content of the pressure-sensitive adhesive is 45%-84%, the pressure-sensitive adhesive is composed of a silicone pressure-sensitive adhesive and an acrylate pressure-sensitive adhesive, and the weight ratio of the silicone pressure-sensitive adhesive to the acrylate pressure-sensitive adhesive is 1: 1-15: 1. According to the transdermal patch, the penetration capacity of ibuprofen is remarkably improved, particularly, the early-stage medicine penetration rate is higher, the medicine utilization rate is greatly improved, meanwhile, the patch is good in application performance, free of skin irritation, free of crystallization in the long-term storage process, good in stability and capable of better meeting the clinical medication requirement.

The invention discloses a zinc porphyrin modified electrode, a preparation method of the zinc porphyrin modified electrode and application of the zinc porphyrin modified electrode in synthesis of ibuprofen from CO2 and aryl halide through electro-catalysis. According to the invention, a zinc porphyrin polymer is immobilized on carbon cloth through pre-assembly and electropolymerization, and a novel zinc porphyrin modified electrode (Zn-TPP-CC) is developed. The electrode shows excellent catalytic performance, and the ibuprofen yield is as high as 96%. Experiments show that the Zn-TPP-CC cathode effectively catalyzes an electrocarboxylation reaction and promotes the generation of alkyl radicals by forming a stable Zn-Cl intermediate, and the process is crucial to subsequent CO2 insertion, so that the total energy barrier of the reaction is remarkably reduced. Evaluation shows that 0.213 kg of CO2 can be fixed when 1 kg of ibuprofen is produced in the process, and compared with a traditional method, carbon emission is reduced by 70.1%. According to the invention, a new view angle is provided for CO2 recycling and green drug synthesis, and the potential of multiphase electro-catalysis in efficient utilization of carbon resources is manifested.

The application relates to a preparation method and application of chiral two-dimensional cadmium sulfide nanosheets. The application aims to solve the problem that it is difficult to construct non-layered chiral two-dimensional inorganic nanomaterials. The method comprises the following steps: placing a first open reaction container and a second open reaction container in a sealable container, adding a cadmium acetate solution into the first open reaction container, then adding a left-rotational ibuprofen / chloroform solution drop by drop, adding a sodium sulfide aqueous solution into the second open reaction container, then adding a hydrochloric acid solution drop by drop, and finally sealing and standing. The application is used for preparing a circularly polarized light detection device for detecting left-rotational / right-rotational circularly polarized light. The application is used for the preparation and application of chiral two-dimensional cadmium sulfide nanosheets.

The invention relates to the technical field of medicines, and discloses a novel light cuspidine type diterpenoid alkaloid compound and application of the novel light cuspidine type diterpenoid alkaloid compound. According to the present invention, the novel C20 selaginine type diterpenoid alkaloids such as the Carmaloidline C, the Carmaloidline D and the Aconialoidline C, which are provided by the present invention, all have significant analgesic effects; wherein the analgesic activity of the Carmaloidline C is the strongest, is superior to that of the positive drug morphine and is obviously superior to that of the positive drug ibuprofen, and the analgesic activity of the Carmaloidline D and the analgesic activity of the Aponiloidline C are superior to that of the positive drug ibuprofen. The medicines can be used for developing analgesic medicines for various acute or chronic pains.

A pharmaceutical composition for intranasal administration and manufacturing method of preparations containing a combination of ibuprofen and ketoprofen at a fraction of the dose required when the same active ingredients are administered orally, useful in the treatment of migraine and other forms of headache.

The invention relates to the technical field of medicines, in particular to ibuprofen water-free swallowing granules and a preparation method thereof. The ibuprofen water-free swallowing particles are composed of medicine carrying particles and taste modifying particles. The medicine-carrying particles comprise the following components in percentage by weight: 50.0 to 95.0 percent of ibuprofen, 0 to 20.0 percent of disintegrating agent, 0.5 to 25.0 percent of adhesive and 0 to 50.0 percent of filling agent. The invention further discloses a preparation method of the medicine-carrying particles. The mass ratio of the ibuprofen to the disintegrating agent to the adhesive is (80-90): (0-10): (5-20). And the adhesive is selected from a low-melting-point adhesive. The medicine-carrying particles are granulated by a hot-melting granulator and then mixed with the taste-modifying particles. The ibuprofen water-free swallowing granules prepared by the invention are convenient to carry, can be rapidly disintegrated in the oral cavity and rapidly release medicines, enter gastrointestinal tracts along with swallowing actions to be absorbed, do not need to be swallowed by water, and are good in medication compliance and particularly suitable for patients with swallowing difficulty to take.

The present invention relates to solid compositions. The present invention addresses the problem of providing a solid composition containing ibuprofen in which changes in properties are suppressed. [Solution] A solid composition comprising the following components: (A) ibuprofen; (B) at least one substance selected from the group consisting of tepiperidine and salts thereof; and (C) at least one compound selected from the group consisting of tranexamic acid and salts thereof, in which the solid composition does not include a solid composition containing levocetirizine or loratadine.

The invention relates to a preparation method of a diamine chiral resolving agent. The method comprises the following steps: by taking chiral alpha-amino acid as a raw material, reacting the chiral alpha-amino acid with (Boc) 2O and alkali in a solvent to obtain Boc-protected amino acid; in a solvent, the Boc-protected amino acid and secondary amine are subjected to catalysis of a condensing agent and alkali to obtain Boc amino-protected secondary amide; dissolving the Boc amino protected secondary amide in an organic solvent, and removing a Boc protecting group under an acidic condition to obtain chiral alpha-amino secondary amide; and reducing the chiral alpha-amino secondary amide into amine under the action of a reducing agent to obtain chiral amino secondary amine, namely the target product diamine chiral resolving agent. The chiral alpha-amino acid required by the preparation method is cheap and easy to obtain, the operation is simple, the obtained chiral diamine resolving agent is novel in structure, the variety of alkaline resolving agents is enriched, and the chiral diamine resolving agent is applied to resolution of racemic propionic acid compounds such as non-steroidal anti-inflammatory drugs ibuprofen and flurbiprofen and has practicability.

Pharmaceutical compositions comprising ibuprofen and methods of making the pharmaceutical compositions using a solventless mixing process are provided. Excess coating material that is not bound to the coated ibuprofen can be removed by a sieving process. The coating and the quantitative ratio can also be optimized to minimize the amount of excess unbound coating material. In addition, the compositions can be formulated to maintain the functional coating of the coated ibuprofen and minimize the exposure of ibuprofen when mixed into a suspension.

A composition comprises an alkali metal salt of a first pharmaceutical ingredient; and a second pharmaceutical ingredient, wherein the second pharmaceutical ingredient is chemically incompatible with the first pharmaceutical ingredient, and the composition is an aqueous solution. The first active pharmaceutical ingredient can comprise ibuprofen or naproxen. The second pharmaceutical ingredient can comprise acetaminophen.

The invention discloses an ibuprofen transdermal patch based on core-shell structure viscous electrostatic spinning fibers and a preparation method of the ibuprofen transdermal patch, and belongs to the technical field of external transdermal patches. A viscous fiber membrane constructed based on core-shell structure electrospun fibers is used as a functional layer; a shell layer of the fibers is formed by curing a spinning solution formed by dissolving a thermoplastic elastomer and natural resin in an organic solvent B, and provides stable viscosity; the core layer is formed by curing a spinning solution formed by dissolving ibuprofen, a hydrophobic polymer and a penetration enhancer in an organic solvent A, and efficient loading and controllable release of drugs are achieved. By optimizing the shell-core flow rate ratio, spinning voltage and other key process parameters, the patch has the characteristics of strong adhesion in the initial stage and easy stripping in the later stage, and meanwhile, it is ensured that the transdermal permeation amount and release rate of the medicine meet the treatment requirements. The patch has the characteristics of high porosity and biphasic drug release which takes effect quickly in the initial stage and is maintained slowly in the subsequent stage, effectively avoids the first-pass effect and the skin irritation risk, and is particularly suitable for local treatment of inflammatory diseases such as acute gouty arthritis and the like.

Disclosed is a method of treating a subject for a respiratory viral infection. The method comprises administering to the subject by inhalation an effective amount of a hypertonic saline solution comprising an ibuprofenate salt.

1. Name of the designed product: packing box (ibuprofen sustained-release capsule). 2. Use of the designed product: the designed product is used for packing. 3. Design points of the designed product: the pattern. 4. Picture or photo best indicating the design points: front view.

The present invention relates to solid compositions. The present invention addresses the problem of providing a novel solid composition. The solution of the invention is to provide a solid composition containing crystals formed by ibuprofen and tranexamic acid, and licorice.

The application discloses a preparation method of a 3D printing anti-inflammatory biodegradable airway stent, and provides a new solution for rapidly preparing a personalized biodegradable airway stent for clinical application. The preparation method comprises the following steps: preparing a customized airway stent by using a 3D printing technology; obtaining an amine crosslinked stent by using a surface modification method; and further obtaining an anti-inflammatory airway stent by using an amidation reaction between ibuprofen and the surface amino group. The process has good repeatability and excellent personalized customization performance, and can be used as an effective means for treating central airway obstruction.

This invention relates to the fields of environmental and chemical technology, specifically to a nitrogen-modified activated carbon adsorbent material, its preparation method, and its applications. The invention employs an ammonium chloride solution impregnation method combined with high-temperature activation under a nitrogen inert atmosphere to modify the surface of pretreated granular activated carbon, increasing the content of basic groups on the activated carbon surface, thus preparing a nitrogen-modified activated carbon adsorbent material. Experimental results show that the prepared nitrogen-modified activated carbon exhibits high adsorption efficiency for carboxylic acid drug pollutants such as naproxen, ibuprofen, and diclofenac. The preparation conditions of this invention are mild, the operation steps are simple, the required reagents are inexpensive, and the safety is relatively high, making it suitable for the treatment of drinking water, sewage, and medical wastewater.