A method and
system are presented for use in noninvasive monitoring at least one parameter of a
region of interest in a
human body. The
system comprises a measurement unit and a
control unit. The measurement unit comprises an optical unit having an illumination
assembly configured to define at least one output port for illuminating light, and a
light detection assembly configured to define at least one light input port for collecting light and to generate measured data indicative of the collected light; and an acoustic unit configured to generate acoustic
waves of a predetermined
ultrasound frequency range. The measurement unit is configured and operable to provide an operating condition such that the acoustic
waves of the predetermined frequency range overlap with an illuminating region within the
region of interest and substantially do not overlap with a region outside the
region of interest, and that the detection
assembly collects light scattered from the region of interest and light scattered from the region outside the region of interest. The measured data is thus indicative of
scattered light having both
ultrasound tagged and untagged light portions, thereby enabling to distinguish between light responses of the region of interest and the region outside the region of interest. The
control unit is connectable to the optical unit and to the acoustic unit to operate these units, and is responsive to the measured data and preprogrammed to process and analyze the measured data to extract therefrom data indicative of a
light response of the region of interest and determine the at least one desired parameter.