2147 results about "High spatial resolution" patented technology

This invention is directed to a 3-dimensional imaging lidar, which utilizes modest power kHz rate lasers, array detectors, photon-counting multi-channel timing receivers, and dual wedge optical scanners with transmitter point-ahead correction to provide contiguous high spatial resolution mapping of surface features including ground, water, man-made objects, vegetation and submerged surfaces from an aircraft or a spacecraft.

The invention consists in structuring scintillation radiation detectors as Photonic Bandgap Crystals or 3D layers of thin filaments, thus enabling extremely high spatial resolutions and achieving virtual voxellation of the radiation detector without physical separating walls. The ability to precisely measure the recoil electron track in a Compton camera enables to assess the directions of the gamma rays hitting the detector and consequently dispensing with collimators that strongly reduce the intensity of radiation detected by gamma cameras. The invention enables great enhancements of the capabilities of gamma cameras, SPECT, PET, CT and DR machines as well as their use in Homeland Security applications. Methods of fabrication of such radiation detectors are decribed.

For the high spatial resolution imaging of a structure of interest in a specimen, a substance is selected from a group of substances which have a fluorescent first state and a nonfluorescent second state; which can be converted fractionally from their first state into their second state by light which excites them into fluorescence, and which return from their second state into their first state; the specimen's structure of interest is imaged onto a sensor array, a spatial resolution limit of the imaging being greater (i.e. worse) than an average spacing between closest neighboring molecules of the substance in the specimen; the specimen is exposed to light in a region which has dimensions larger than the spatial resolution limit, fractions of the substance alternately being excited by the light to emit fluorescent light and converted into their second state, and at least 10% of the molecules of the substance that are respectively in the first state lying at a distance from their closest neighboring molecules in the first state which is greater than the spatial resolution limit; and the fluorescent light, which is spontaneously emitted by the substance from the region, is registered in a plurality of images recorded by the sensor array during continued exposure of the specimen to the light.

A method increases the spatial resolution of a source image based on an auxiliary, co-registered image of a higher spatial resolution. Each of the source and auxiliary images includes a plurality of pixels with corresponding spectral intensities and the method includes reducing, identifying, deriving, subdividing and modifying steps. Multiple auxiliary images can be used with the method.

In the reducing step, a spatial resolution of the auxiliary image is reduced to a common resolution with the source image. Then in the identifying step, corresponding groups of pixels at the common resolution in the source and auxiliary images are identified. Then in the deriving step, a mapping function is derived which relates the rate of change of intensity of each group in the auxiliary image and the corresponding rate of change of intensity in the corresponding group in the source image to the intensity vector. This map can be conditioned on any number of auxiliary image planes.

In the subdividing step, each source pixel is subdivided. Then in the modifying step, the spectral intensity of each subdivided source pixel is modifying based on the map and the local intensity variations of the auxiliary image. This results in increasing the resolution of the source image.

The present invention belongs to the field of fine surface structure measuring technology, and relates to one kind of differential confocal scanning detection method with high spatial resolution. Differential confocal microscopic double receiving light path configuration and double detector subtraction form the differential confocal signal in measuring the workpiece. Optical super-resolution confocal microscopic detection method is adopted to raise the transverse resolution, and differential confocal microscopic detection method is adopted to raise the longitudinal resolution, so as to reach differential confocal scanning detection of high spatial resolution. The method can meet the requirements in high spatial resolution, high precision and great measurement range, and is especially suitable for the measurement of fine surface 3D structure, miniature steps, miniature grooves, line width, surface appearance, etc.

The present disclosure relates to methods of and systems for modifying the transcriptional regulation of stem or progenitor cells to promote their differentiation or reprogramming of somatic cells. Further, the labeling and editing of human genomic loci in live cells with three orthogonal CRISPR/Cas9 components allow multicolor detection of genomic loci with high spatial resolution, which provides an avenue for barcoding elements of the human genome in the living state.

Conventional electro-optical imaging systems can not achieve wide field of view (FOV) and high spatial resolution imaging simultaneously due to format size limitations of image sensor arrays. To implement wide field of regard imaging with high resolution, mechanical scanning mechanisms are typically used. Still, sensor data processing and communication speed is constrained due to large amount of data if large format image sensor arrays are used. This invention describes an electro-optical imaging system that achieves wide FOV global imaging for suspect object detection and local high resolution for object recognition and tracking. It mimics foveated imaging property of human eyes. There is no mechanical scanning for changing the region of interest (ROI). Two relatively small format image sensor arrays are used to respectively acquire global low resolution image and local high resolution image. The ROI is detected and located by analysis of the global image. A lens array along with an electronically addressed switch array and a magnification lens is used to pick out and magnify the local image. The global image and local image are processed by the processor, and can be fused for display. Three embodiments of the invention are descried.

Techniques for monitoring and predicting environmental operating conditions in a data center are provided. In one aspect, a method for real-time, three-dimensional analysis of environmental operating conditions in a data center includes the following steps. High spatial resolution three-dimensional measurements of one or more environmental variables in the data center made at a time t₁ are obtained. Real-time measurements of the environmental variables in the data center made at a time t₂, wherein t₂ is later in time than t₁, are obtained. The high spatial resolution three-dimensional measurements are combined with the real-time measurements to derive a model for the environmental variables in the data center at the time t₂. The model is used to predict three-dimensional distributions of the environmental variables in the data center at the time t₂. A base model can be created and used to derive the model for the data center at the time t₂.

In a method of high spatial resolution imaging a structure of a sample, the structure is marked with a substance. The substance is selected from a group of substances which are capable of being repeatedly transferred out of a first state having first optical properties into a second state having second optical properties by means of an optical switch over signal, and which are capable of returning out of the second state into the first state, the two states differing with regard to at least one criteria. Within areas of the sample the sample is transferred into the second state by means of the optical switch over signal with which at least one spatially limited area of the sample is purposefully omitted. An optical measurement signal is detected, which is associated with the substance in the first state and which comes out of a detection area including both the area purposefully omitted with the switch over signal and areas in which the substance has been transferred into to second state.

Apparatus and method for high spatial resolution imaging of a sample's structure, including a diffraction-limited resolution volume with a plurality of dye molecules which can be switched between different states and have a distribution density which is greater than the inverse of the diffraction-limited resolution volume, where at least one state is fluorescing, the fluorescence being collected by an objective lens and imaged on a spatially resolving detector by an optical system. At least one light source provided for emitting a switching radiation and for emitting an excitation radiation. At least one of the light sources is arranged to radiate through the sample, and a switching and/or fluorescence excitation of the dye molecules is carried out. The switching is a photoactivation or a photodeactivation of the dye molecules. A focusing arrangement is provided for switching and/or for excitation to generate a line-like illumination region extending in a direction of illumination.

This invention relates to a method of forming a three-dimensional (3D) dosimetric map in a solid translucent or transparent polymer and to an article of manufacture comprising a polymer formulated to capture data imparted by incident penetrating radiation. The present invention provides a method of preparation of a solid translucent or transparent polymer matrix capable of detecting and displaying a dose or doses of penetrating radiation by forming within the polymeric matrix a 3D dosimetric map which is measurable and quantifiable by various known procedures. The dosimetric map is representative of the 3D distribution of the dose or doses of the penetrating radiation to which the polymer had been exposed and can be quantified at high spatial resolution, thereby providing an accurate, stable, storable record in three dimensions of the radiation exposure or dosing event(s).

The present invention relates to a method for the histologic classification of a tissue section. The method includes acquiring a mass spectrometric image and a light-optical image of the same tissue section (the optical image having a higher spatial resolution than the mass spectrometric image) and combining optical information on the structures of a subarea of the tissue section with mass spectrometric information on the subarea (the structures not being spatially resolved in the mass spectrometric image).

The present invention includes a method for parallel magnetic resonance imaging termed Superresolution Sensitivity Encoding (SURE-SENSE) and its application to functional and spectroscopic magnetic resonance imaging. SURE-SENSE acceleration is performed by acquiring only the central region of k-space instead of increasing the sampling distance over the complete k-space matrix and reconstruction is explicitly based on intra-voxel coil sensitivity variation. SURE-SENSE image reconstruction is formulated as a superresolution imaging problem where a collection of low resolution images acquired with multiple receiver coils are combined into a single image with higher spatial resolution using coil sensitivity maps acquired with high spatial resolution. The effective acceleration of conventional gradient encoding is given by the gain in spatial resolution Since SURE-SENSE is an ill-posed inverse problem, Tikhonov regularization is employed to control noise amplification. Unlike standard SENSE, SURE-SENSE allows acceleration along all encoding directions.