1970 results about "Target tissue" patented technology

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

Systems, devices, and methods for performing a cosmetic procedure on a patient are provided herein. A system includes at least one treatment device. Each treatment device having a set of multiple treatment modules. Each treatment module having at least one coring element and at least one actuation assembly. Each actuation assembly being operably attached to at least one treatment module of the set of multiple treatment modules and performing a microcoring procedure that includes the attached treatment module translating in a series of reciprocating motions. Each reciprocating motion includes each coring element of the attached treatment module being inserted into and withdrawn from target tissue of a patient.

The invention discloses a drug resistance prediction method and system based on comparative learning and multi-modal fusion, and the method comprises the steps: firstly generating a molecular map and a molecular fingerprint based on the SMILES of a target drug, and extracting the molecular features of the drug through a comparative learning model constructed through combining a map attention network and a map convolution network; and then, acquiring protein expression, gene expression and metabolic expression data from the target tissue cells, extracting modal features through a deep convolutional network, a Transform encoder and a multi-dimensional attention network, and realizing adaptive fusion of the multi-modal features through a heterogeneous interactive attention mechanism. And finally, jointly inputting the fused multi-modal features and drug molecular features into a multi-layer sensor to realize high-precision prediction of the drug resistance of cells to drugs. By introducing a contrast learning and multi-modal feature fusion mechanism, the characterization capability and prediction precision of the model are effectively improved, and efficient and reliable support can be provided for drug screening and clinical decision making.

Disclosed herein are implantable intraocular drug delivery devices structured to provide targeted and / or controlled release of a drug to a desired intraocular target tissue, and methods of implanting and methods of using such devices for the treatment of ocular diseases and disorders. In certain embodiments, some, most, or essentially all of the device is made of biodegradable materials.

The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.

A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.

The invention discloses a skin targeted therapy laser control method and system based on a dual-wavelength synergistic effect, and the method comprises the steps: collecting the real-time morphological characteristics and pigment distribution data of skin tissues through a multispectral imaging unit, and recognizing the optical characteristic parameters of a target treatment region; generating a dual-wavelength combination scheme through a dynamic wavelength selection algorithm based on the optical characteristic parameters and the tissue structure characteristics of the target treatment area; according to a dual-wavelength combination scheme, generating a synergistic laser sequence with a specific pulse interval and energy ratio; the synergistic laser sequence is converted into a driving signal, and a dual-wavelength laser is controlled to output composite laser; and laser output parameters are dynamically adjusted through real-time thermal diffusion monitoring and an optical feedback mechanism. By utilizing the embodiment of the invention, accurate and selective heat dissipation of skin target tissues can be realized, surrounding normal tissues are effectively protected, the treatment safety and effectiveness are improved, and side effects are reduced.

One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source. The neuromuscular stimulator can include a controller and at least one electrode. The controller can be configured to receive certain power and stimulation parameters associated with a therapy signal from the power source. The at least one electrode can be configured to deliver the therapy signal to a target tissue associated with control of a posterior base of the tongue of the subject.

The invention discloses an imaging equipment positioning guiding method, system and equipment based on sparse reconstruction, and the method comprises the steps: employing imaging equipment, and automatically collecting 2D images of a designated region of a simulation patient from a plurality of sparse angles; selecting a target tissue to be modeled on the 2D image; performing 3D modeling on the selected target tissue by adopting an extremely sparse reconstruction algorithm to form a 3D modeling image of the target tissue; registering the 3D modeling image and the 2D image, and calculating a first conversion relation between a visual coordinate system and a motion coordinate system of the imaging equipment; adjusting the initial pose of the 3D modeling image, and calculating the target position of the imaging device corresponding to the adjusted pose based on the first conversion relation and the adjusted pose of the 3D modeling image; and controlling the imaging equipment to reach the target position so as to obtain an expected imaging view angle of the target tissue.

An objective of the present disclosure is to provide anti-CD137 antigen-binding molecules which have immunocyte-activating effect, cytotoxic activity, or anti-tumor activity, and meanwhile have reduced effect on non-tumor tissues such as normal tissues and produce less side effects, and methods of using the same.Anti-CD137 antigen-binding molecules which have immunocyte-activating effect, cytotoxic activity, or anti-tumor activity, and meanwhile have reduced effect on non-tumor tissues such as normal tissues and produce less side effects, are provided by discovering and producing CD137 antigen-binding molecules whose binding activity to CD137 depends on various substances (for example, small molecule compounds) in target tissues. Methods of using the same, pharmaceutical formulations, and such are also provided.The present disclosure also provides an antigen-binding molecule whose binding activity to an antigen varies depending on a small molecule compound, a preparation method thereof, and uses thereof.

The inventions provided herein relate to injection applicators, tissue markers and uses thereof, e.g., to mark a target tissue site (e.g., a biopsy site in a breast tissue) or to produce a cell scaffold. The tissue markers described herein are designed to be resistant to fast migration (e.g., immediate migration after implantation through a needle track) and slow migration (e.g., over an extended period of time) upon implantation at a target tissue site (e.g., a biopsy site in a breast tissue), without using an adhesive. Additionally or alternatively, the tissue markers described herein can be readily detectable by at least one imaging modality, e.g., but not limited to magnetic resonance imaging, X-ray imaging, ultrasound imaging, or a combination thereof.

Treatment of damaged, diseased, abnormal, obstructive, cancerous or undesired tissue (e.g. a tumor, a benign tumor, a malignant tumor, a cyst, or an area of diseased tissue, etc) is provided by delivering specialized pulsed electric field energy to target tissue areas in a specific dose so as to obtain a superior outcome. The specialized PEF energy and delivery has been optimized to provide advanced treatment of target tissue areas, including destruction of undesired tissue and generation of improved inflammatory and immune responses. The specialized PEF energy provides superior outcomes to radiofrequency ablation and irreversible electroporation.

The invention relates to the technical field of ultrasonic scanning imaging, and discloses an ultrasonic robot real-time trajectory planning method and system based on an ultrasonic image. The trajectory planning method is applied to the ultrasonic scanning robot and specifically comprises the following steps that S101, an area where a target tissue is located is obtained, continuous scanning is carried out, an image of a cross section is obtained in real time, meanwhile, preliminary positioning of an ultrasonic probe is completed, and each frame of collected image and posture data of a current mechanical arm are synchronously recorded; and S102, carrying out image segmentation processing on the obtained image of the cross section, identifying a target structure region represented in each frame of image, accurately separating the target structure region from a complex background, obtaining the target segmentation of each frame of image, and then entering a spatial modeling stage. According to the method, the quality and robustness of the ultrasonic diagnosis image are improved by using the advantages of high learning efficiency and good generalization of the deep learning model, and the problem of poor online real-time adjustment capability in the current ultrasonic detection technology is solved.

An apparatus includes a catheter assembly and an end effector. The catheter assembly includes an outer sheath with a distal end. The end effector is associated with a distal end of the catheter assembly. The end effector includes a panel assembly with microelectrodes for electrophysiological (EP) mapping. The microelectrodes are configured in a matrix within the panel assembly and provide multiple points of contact with the target tissue for EP mapping. The panel assembly can transition between a first contracted state and a second expanded state. The panel assembly can fit within the outer sheath in the first state. The panel assembly can expand outwardly away from a longitudinal axis defined by the catheter assembly in the second state once exposed distally relative to the distal end of the outer sheath.

A system to configure a neurostimulation signal to a patient's body has a neurostimulator to create a base stimulation signal which has a series of first pulses. A computer processor within the neurostimulator deconstructs the first series of pulses into a first and second partial pulse series which have respective first and second partial electrical pulses where the first and second partial electrical pulses substantially summate to the base stimulation signal. A programmable signal generator provides a constant amplitude of combined stimulation pulses by applying the first and second partial pulses to a number of contacts of an electrode positionally located to stimulate a target tissue in the patient's body.

Provided herein are systems, devices, and methods for treating tissue of a patient. The system includes a first energy delivery device having a first energy delivery element to be positioned proximate target tissue of the patient, a second energy delivery element, an energy delivery console to provide energy between the first energy delivery element and the second energy delivery element, and a user interface having a display for providing information to a user. The energy provided by the energy delivery console creates one or more electric fields within an energy delivery volume proximate the first energy delivery element, and at least one electric field within the energy delivery volume is sufficient to irreversibly electroporate target tissue within the energy delivery volume.

Devices and methods are disclosed for treating tissue with microwave energy. Such devices and methods are able to treat cavities or surface tissue by creating one or more area or volumetric lesions. Also disclosed are flexible, low-profile devices that can be inserted non-invasively or minimally invasively near or into the target tissue as well as microwave antennas designed to generate ablation profiles that can ablate a large area or a large volume of target tissue in a single ablation. The devices include antennas wherein the field profile generated by an antenna is tailored and optimized for a particular clinical application. The antennas use unique properties of microwaves such as interaction of a microwave field with a metallic object and the use of additional shaping elements to shape the microwave field.

Surgical systems and methods for tracking physical objects near a target site during a surgical procedure are provided, the surgical system employs a navigation system and a surgical instrument; an instrument tracker is provided on the surgical instrument and a patient tracker is provided on the patient's target tissue; the system and method is configured to detect an error condition compromising accuracy of the navigation guidance and to track and monitor a tool-to-bone offset.

The invention provides a radio frequency therapeutic instrument control method, and relates to the technical field of medical instruments, and the method comprises the steps: obtaining the dynamic change information of a target tissue surface temperature field in real time through collecting the dynamic temperature data of a target tissue surface; setting a temperature control constraint of the radio frequency therapeutic apparatus according to a plurality of temperature deviation indexes corresponding to the temperature sudden change area; performing region communication on the heat distribution rule in the temperature mutation region to obtain a temperature compensation boundary corresponding to the temperature mutation region on the surface of the target tissue, and determining a temperature change compensation trend of the radio frequency therapeutic apparatus according to the temperature compensation boundary and the dynamic temperature data; and determining multi-stage radio frequency treatment signals of the radio frequency treatment instrument in different temperature fields according to the temperature control constraint and the temperature change compensation trend, and matching temperature control strategies of the radio frequency treatment instrument according to the multi-stage radio frequency treatment signals. According to the invention, intelligent matching of temperature control strategies can be realized through multi-stage radio frequency treatment signals, so that the stability of temperature control of the radio frequency therapeutic apparatus is improved.

A system for treating tissue includes a cap mounted over a distal end of an endoscope, a clip mountable over the cap and including first and second jaws movably connected to one another between an insertion configuration, in which the first and second jaws extend over the cap to receive a target tissue therebetween, a review configuration, in which at least a portion of the clip extends into a field of view of the optical system of an endoscope, and a deployed configuration in which the clip is moved distally off of the cap so that the first and second jaws are drawn toward one another. A control element is configured so that movement proximally through the cap via a first distance moves the clip from the insertion configuration to the review configuration and a second distance moves the clip from the review configuration to the deployed configuration.

A device for ablating target tissue of a patient with electrical energy is provided. An elongate shaft includes a proximal portion and a distal portion, and a radially expandable element is attached to the distal portion. An ablation element for delivering electrical energy to target tissue is mounted to the radially expandable element. The device can be constructed and arranged to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided.

A device for ablating target tissue of a patient with electrical energy is provided. An elongate shaft includes a proximal portion and a distal portion, and a radially expandable element is attached to the distal portion. An ablation element for delivering electrical energy to target tissue is mounted to the radially expandable element. The device can be constructed and arranged to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided.

The invention relates to the technical field of laser medical treatment, and discloses a thulium laser emission control system and method.The system comprises a tissue feedback acquisition module, a parameter identification module, a control strategy module, a laser control module and an execution control module; according to the method, thermal response data of a target tissue under the action of laser are collected in real time, thermal parameters of the target tissue are dynamically calculated, a control target and constraint conditions are constructed based on the parameters, and a laser control parameter combination matched with the tissue state is determined and used for adjusting the output power, pulse width and frequency of a thulium laser. And real-time control and parameter updating in the laser emission process are realized. According to the invention, accurate matching of laser output parameters and tissue thermal states is realized, laser power, pulse width and frequency can be dynamically adjusted in the treatment process, the real-time performance and response capability of laser treatment are improved, and the safety, treatment effect and individual adaptability of urinary surgery are significantly enhanced.

The invention relates to a radionuclide-labeled glucose derivative molecular probe and application thereof, and belongs to the technical field of nuclear medicine. According to the present invention, propargyl glycine is used to synthesize an amino acid skeleton, and the amino acid skeleton reacts with glucose azide to prepare a series of radionuclide-labeled glucose derivative molecular probes, such as [68Ga] Ga-NOTA-SDG, [68Ga] Ga-NOTA-DDG, [68Ga] Ga-NOTA-TDG, [68Ga] Ga-DOTA-SDG, [68Ga] Ga-DOTA-DDG and the like; the glucose derivative molecular probe labeled by the series of radionuclides has the advantages of being simple and rapid in labeling, high in radiolabeling yield and good in stability, can accurately position tumors, has good tumor uptake and lower non-target tissue uptake, and has great application prospects in preparation of broad-spectrum tumor imaging agents.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. Treatment planning systems are also provided for preparing and implementing a digital treatment plan. The treatment planning can include dividing a target tissue volume into a plurality of treatment locations, and controlling the speed, and pattern of movement between these tissue locations.

A system to perform electroporation ablation of target tissue in a chamber of a patient's heart, the system comprising a catheter and a controller. The catheter includes an electrode assembly having a plurality of ablation electrodes, wherein the catheter is adapted to position the electrode assembly in contact with the target tissue. The controller is configured to identify, from among the plurality of ablation electrodes, a first subset of ablation electrodes that are in contact with the target tissue, and a second subset of ablation electrodes that are not in contact with the target tissue, and to apply a pulsed electrical signal to the first subset of ablation electrodes and not to the second subset of ablation electrodes.

The invention discloses an acid responsive nanoprobe as well as preparation and anti-tumor application thereof. The nanoprobe has a core-shell structure, takes a nanoparticle self-assembled by a polycation aggregation-induced emission (AIE) photosensitizer and functional nucleic acid as a core, and takes a hyaluronic acid modified metal polyphenol network as a shell. The nanoprobe utilizes the acid responsiveness and broad-spectrum absorption performance of the metal polyphenol network and the diagnosis and treatment advantages of the polycation AIE photosensitizer to realize the acid responsiveness'switch 'controllable diagnosis and treatment of the tumor nanoprobe. In a neutral environment, the fluorescence is weak, the generation of ROS is less, and the background noise signal of the nanoprobe and the toxicity of non-targeted tissues are reduced; in an acid environment, fluorescence is enhanced, the ROS yield is improved, and the treatment efficiency and the curative effect monitoring accuracy are improved. The nano diagnosis and treatment probe is ingenious in design and simple to prepare, and can realize PDT and gene therapy synergistic anti-tumor, in-situ real-time report of early tumor treatment effect and assistance in precise cancer treatment.

A system to treat a patient comprises a user interface that allows a physician to view an image of tissue to be treated in order to develop a treatment plan to resect tissue with a predefined removal profile. The image may comprise a plurality of images, and the planned treatment is shown on the images. The treatment probe may comprise an anchor, and the image shown on the screen may have a reference image marker shown on the screen corresponding to the anchor. The planned tissue removal profile can be displayed and scaled to the image of the target tissue of an organ such as the prostate, and the physician can adjust the treatment profile based on the scaled images to provide a treatment profile in three dimensions. The images shown on the display may comprise segmented images of the patient with treatment plan overlaid on the images.

The invention provides a visible light and short wave infrared fluorescent endoscopic imaging system and method, and belongs to the technical field of fluorescent endoscopic imaging, and the system comprises an endoscope which is used for guiding a light signal into a position needing to be checked and collecting a light signal reflected or transmitted from a target tissue; a light source; the light source adopts a multimode light source and is connected with the endoscope through an optical fiber; a camera module; the camera module is connected with the endoscope through the optical bayonet, and the camera module can receive optical signals output by the endoscope and convert the optical signals into image information; and the controller is in control connection with the light source, the camera module and the display, the camera module transmits the image information into the controller for processing, and the display displays the image information processed by the controller. By fusing the visible light imaging mode and the short wave infrared fluorescence imaging mode, surface details and deep structure information of the tissue can be captured at the same time, and the high-resolution and high-definition imaging effect is achieved.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are systems and methods for acoustically coupling a histotripsy therapy system to the skin of a patient to provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.