1015 results about "Target tissue" patented technology

The invention discloses a skin targeted therapy laser control method and system based on a dual-wavelength synergistic effect, and the method comprises the steps: collecting the real-time morphological characteristics and pigment distribution data of skin tissues through a multispectral imaging unit, and recognizing the optical characteristic parameters of a target treatment region; generating a dual-wavelength combination scheme through a dynamic wavelength selection algorithm based on the optical characteristic parameters and the tissue structure characteristics of the target treatment area; according to a dual-wavelength combination scheme, generating a synergistic laser sequence with a specific pulse interval and energy ratio; the synergistic laser sequence is converted into a driving signal, and a dual-wavelength laser is controlled to output composite laser; and laser output parameters are dynamically adjusted through real-time thermal diffusion monitoring and an optical feedback mechanism. By utilizing the embodiment of the invention, accurate and selective heat dissipation of skin target tissues can be realized, surrounding normal tissues are effectively protected, the treatment safety and effectiveness are improved, and side effects are reduced.

An ablation system is disclosed. The ablation system comprises a tubular ablation catheter and an ablation instrument. The catheter comprises a far end used for being attached to target tissue to be ablated, a near end used for being connected with the ablation instrument and a catheter body located between the far end and the near end. The ablation instrument transmits radio frequency / pulse energy to the ablation catheter, so that the catheter ablates the target tissue; the electrode group at the far end is used for collecting electrocardiosignals of target tissues and transmitting the electrocardiosignals to the three-dimensional heart electrophysiological mapping system to realize heart modeling and mapping, and each electrode has the capabilities of collecting the electrocardiosignals and ablating the target tissues; and the electrode group receives a control signal from the ablation instrument, and determines that the electrodes in the electrode group work in a single-pole / double-pole mode according to the control signal and realizes dotted / linear ablation. According to the system, mapping and ablation functions are integrated in a single catheter, two purposes are achieved through one catheter, flexible switching of various ablation modes / shapes / energy is supported, and high universality is achieved.

The invention belongs to the technical field of medical imaging, and provides a tissue stress measurement method and system based on a reverberation shear wave field, and the method comprises the steps: applying steady-state harmonic excitation, and obtaining the reverberation shear wave field of a target tissue; determining a stress direction according to the prior information of the target tissue, and constructing a stress direction vector; constructing an analytic operator, and extracting an intermediate characteristic quantity of the reverberation shear wave field; and according to the intermediate characteristic quantity, combining stress direction inversion to reconstruct spatial stress distribution. According to the method, a complex reverberation wave field is modeled into superposition of multi-direction propagation wavelets by utilizing anisotropic propagation characteristics of shear waves and combining a traveling wave expansion model, and characteristic quantities related to local stress and material parameters are directly extracted from the reverberation wave field by designing a wave field operator with physical significance; the three technical problems existing in a traditional shear wave elastic imaging technology are solved, the dependence of a traditional method on a single propagation direction and wave pattern controllability is broken through, and in-situ, in-vivo and non-invasive quantification is achieved.

The invention discloses a biological scaffold viscoelasticity evaluation method and related equipment, and aims to overcome the defects of an existing biological scaffold viscoelasticity test method and biological tissue suitability quantitative evaluation. The method comprises the following steps: determining a target implantation part, and acquiring force relaxation experimental data of a biological scaffold by using an atomic force microscope; judging a contact point of the probe and the bracket based on the data; determining the moment when the force signal is stable after the support is compressed to the preset deformation according to the contact point as a force relaxation starting point; calculating the characteristic time when the force value is attenuated to half by taking the starting point as a timing starting point as a microscopic viscoelasticity index; and finally, realizing quantitative evaluation of viscoelasticity suitability by comparing the characteristic time of the stent and the target tissue.

To provide a system, a suturing device and a method for deployment of a stranded anchor via an endoscope.SOLUTION: The present disclosure relates generally to devices for endoscopic suture ends. In some embodiments, a suturing device 100 may include an elongate member 102 having a working channel 110 and a suture channel 112, the elongate member 102 having a proximal end 106 and a distal end 108. The suturing device 100 may further include a suture extending through the suture channel 112 and a plurality of anchor elements coupled to the suture such that the suture and the plurality of anchor elements may be deployed from the elongate member 102 for engagement with the target tissue 116.SELECTED DRAWING: Figure 2A

The invention belongs to the technical field of medical robots and minimally invasive surgery, and provides a robot control system and method for blue laser vaporization surgery of prostatic hyperplasia. Mapping the nuclear magnetic image volume data to a deformation field under an ultrasonic acquisition coordinate system, and deforming the preoperative nuclear magnetic image to an intra-operative ultrasonic space by using the deformation field to complete image registration; fusing the registered image with a stereoscopic vision system; the spatial depth of the surface of the target tissue is obtained from the endoscopic image so as to supplement navigation information; according to the utility model, the prostate deformation and probe posture change adaptive capacity in an operation is improved, the real-time visual closed-loop regulation and control capacity is improved, and the characteristics of small light spots, shallow heat diffusion, excellent hemostasis and the like of blue laser are combined, so that the vaporization and hemostasis precision in a tiny blood vessel dense area is ensured, and the problems of large tissue trauma and the like are avoided.

The invention relates to the technical field of drug release control. By providing a multi-modal data fusion nano-drug release kinetics prediction method, device and equipment and a medium, the method comprises the following steps: acquiring permeation path image data of a nano-drug in a target tissue, and acquiring drug release rate chemical data; performing time dimension synchronization processing on the permeation path image data and the drug release rate chemical data to generate a multi-modal space-time correlation data set; performing feature extraction processing on the multi-modal time-space correlation data set to obtain nano-drug permeation behavior features and release dynamics fluctuation features; constructing a space-time diagram neural network prediction model; training the space-time diagram neural network prediction model to obtain a trained prediction model; and generating a personalized drug release scheme through a reverse optimization algorithm on the basis of the drug release kinetics prediction curve and the quantitative index of the degree of variability, so as to achieve the technical effects of improving the prediction precision, enhancing the model adaptability and reducing the curative effect volatility.

The invention discloses a traditional Chinese medicine prescription efficacy prediction system and method based on a dual-encoder Transformer, and belongs to the technical field of crossing of artificial intelligence and traditional Chinese medicine informatization. Constructing a double-layer embedding expression module comprising a drug embedding layer and a chemical component embedding layer; extracting component aggregation expression of each medicine by using a grading Transform encoder and a content gating attention mechanism; dynamically fusing the expression into the input of a drug-grade encoder through a component information injection module; a compatibility perception bias matrix is introduced into a drug-grade encoder to learn the compatibility relationship between drugs; and finally, based on prescription comprehensive representation output by a drug-grade encoder, synchronously outputting probability distribution of disease indications and targeted tissues through a multi-task prediction module. According to the method, collaborative modeling of the hierarchical structure of the traditional Chinese medicine prescription is realized, the dynamic nature of feature representation and the prediction accuracy are improved, and multi-task learning and the interpretability of a prediction result are supported.

The invention provides a construction method of a plant tissue space transcriptome sequencing library, which comprises the following steps: fixing and embedding plant tissues to obtain embedded blocks; performing autofluorescence detection and tissue permeabilization treatment on part of the embedded blocks, and determining an autofluorescence threshold value and target tissue permeabilization time; slicing, pasting and fixing the remaining embedding blocks, and performing microscope fluorescence scanning detection and tissue permeabilization treatment on the tissue-containing chip according to an autofluorescence threshold value and target tissue permeabilization time to obtain a permeabilized tissue chip; and carrying out reverse transcription, tissue removal, cDNA release, recovery and amplification on the permeabilized tissue chip to obtain a cDNA amplification product. The plant tissue transcript constructed by the construction method is not easy to diffuse and high in capture rate, high-quality in-situ capture time-space group data can be obtained, the accuracy and the credibility are high, the sequencing accuracy is ensured, and the application value is high.

The invention relates to an immune sensitization IRE treatment platform based on NK cell membrane coated manganese carbonate. A manganese carbonate composite nano material is formed by coating the surfaces of manganese carbonate nano particles with cell membranes. According to the invention, higher tumor specificity enrichment is realized, non-target tissue accumulation and systemic toxicity risks are reduced, collaborative integration of tumor targeted delivery, immune activation and IRE ablation is realized, and compared with single IRE, anti-tumor immune response is significantly enhanced.

Transcorneal and fiberoptic laser delivery systems and methods for the treatment of eye diseases wherein energy is delivered by wavelengths transparent to the cornea to effect target tissues in the eye for the control of intraocular pressure in diseases such as glaucoma by delivery systems both external to and within ocular tissues. External delivery may be affected under gonioscopic control. Internal delivery may be controlled endoscopically or fiberoptically, both systems utilizing femtosecond laser energy to excise ocular tissue. The femtosecond light energy is delivered to the target tissues to be treated to effect precisely controlled photodisruption to enable portals for the outflow of aqueous fluid in the case of glaucoma in a manner which minimizes target tissue healing responses, inflammation and scarring.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

In some embodiments, an apparatus includes a handle assembly configured to be coupled to a tissue excision device. The tissue excision device can be configured to excise a target tissue site from a lung. The handle assembly can be configured to transition between a first operation and a second operation mode. The handle assembly in the first operation mode configured to form a portion of a tissue column. The handle assembly in the second operation mode configured to separate the tissue column from surrounding tissue, the handle assembly configured to transition from the first operation mode to the second operation mode after the tissue excision device forms a tissue column including the target tissue site.

The invention relates to the technical field of medical equipment, and provides a focused ultrasound system with multiple treatment modes. A power driving unit; the treatment head comprises a first ultrasonic transducer which is connected with the power driving unit and is used for responding to the excitation signal to form focused ultrasound and outputting the focused ultrasound to a focus; the control unit is suitable for determining a treatment plan according to the tissue characteristic information, and the treatment plan comprises the following steps: performing focused ultrasound irradiation on the target tissue by adopting one or more cooperative treatment modes adaptive to the tissue characteristic information; and controlling the power supply unit and the power driving unit to perform corresponding signal output based on the treatment plan, wherein the plurality of treatment modes comprise a heat effect mode and a histotripsy mode. The focused ultrasound system integrating multiple treatment modes is achieved, one or more matched modes can be selected for cooperative treatment based on tissue characteristics, the treatment efficiency and effect are effectively improved, and operation is convenient.

The invention relates to the field of laser medical instruments, and discloses a spectrum detection-based multi-wavelength optical fiber laser treatment diagnostic machine, which comprises a power supply system, a laser module, a spectrum identification module, a control system, a display operation system and an optical fiber for coupling laser, and the power supply system is respectively connected with the laser module and the spectrum identification module. A treatment and feedback shared optical path structure is adopted, and coaxial transmission of high-power treatment laser and weak biological spectrum signals in the same optical fiber is realized by using an optical signal separation unit. Compared with a traditional technical scheme of an external independent probe, the structure does not need to add an additional intervention detection part, not only simplifies a handheld end operation mechanism, but also ensures that a spectrum collection view field and a laser thermal action area are highly overlapped in space, and the detection accuracy is improved. Therefore, the real biological physicochemical characteristics of the target tissue in the treatment process can be obtained in real time and in situ, and the judgment error caused by the deviation of the detection position is eliminated.

Systems and methods utilizing RF energy to treat a patient's skin (e.g., dermis and hypodermis) or other target tissue including at a depth below a tissue surface (e.g., skin surface, mucosal surfaces of the vagina or esophagus) are provided herein. In various aspects, the methods and systems described herein can provide a RF-based treatment in which the deposition of RF energy can be selectively controlled to help ensure heating uniformity during one or more of body sculpting treatment (lipolysis), skin tightening treatment (laxity improvement), cellulite treatment, vaginal laxity or rejuvenation treatment, urinary incontinence treatment, fecal incontinence treatment, all by way of non-limiting examples. In various aspects, the systems can comprise one or more sources of RF energy (e.g., a RF generator), a treatment applicator comprising one or more electrode arrays configured to be disposed in contact with a tissue surface, and a return electrode (e.g., a neutral pad) to the tissue surface.

Devices, systems, and methods are provided for imaging cholesteatoma, e.g., using an endoscope including a light source configured to deliver visible light at one or more narrowband wavelengths distally from the endoscope selected to cause autofluorescence in target tissue, a camera coupled to the imaging element to acquire image signals of locations beyond the distal end, and one or more filters configured to remove wavelengths of light in the image signals acquired by the camera including the one or more narrowband wavelengths of visible light.

The invention discloses a magnetic control soft robot with electrical stimulation and drug release functions, and relates to the technical field of medical instruments. In the magnetic control soft robot provided by the invention, the magnetic layer is used for driving the body to move and position in the gastrointestinal tract under the driving of an external magnetic field; the electric control layer is used for supplying power and is responsible for controlling the opportunity and parameters of electric stimulation and controlling a drug release instruction; after a microneedle of the conductive hydrogel microneedle layer penetrates into tissue, nerve endings or muscle cells can be stimulated by applying a weak electric signal so as to regulate gastrointestinal motility, relieve pain and the like, a drug can be loaded in the microneedle, and when the electric signal is applied, the drug can be loaded in the microneedle by means of electromigration, electroosmosis and the like. Triggering the drug to be controllably released into the target tissue as required; the adhesive layer is used for temporarily anchoring the robot at a specific working position of the gastrointestinal tract; according to the magnetic control soft robot and the preparation method thereof, the comprehensive requirements of gastrointestinal tract disease treatment can be met.

The disclosure relates to compositions, methods, and processes for the preparation, use, and / or formulation of adeno-associated virus capsid proteins, wherein the capsid proteins comprise targeting peptide inserts for enhanced tropism to a target tissue.

Systems and methods are disclosed for using patient-specific anatomical models and physiological parameters to predict viability of a target tissue or vessel to guide diagnosis or treatment of cardiovascular disease. One method includes: receiving a patient-specific vessel model and a patient-specific tissue model of a patient anatomy; receiving one or more patient-specific physiological parameters (e.g. blood flow, anatomical characteristics, etc.) for one or more physiological states; estimating a viability characteristic of the patient-specific tissue or vessel model (e.g., via a trained machine learning algorithm), using the patient-specific physiological parameters; and outputting the viability characteristic to an electronic storage medium or display.

A method of positioning a cryoprobe includes receiving a cryoprobe repositioning selector indicating a desire to reposition a cryoprobe relative to a target tissue; obtaining cryoprobe operating information from one or more sensors positioned in the cryoprobe, wherein the cryoprobe operating information characterizes one or more operating parameters of the cryoprobe; energizing a heater in the cryoprobe to heat a tip of the cryoprobe to a predetermined cautery temperature threshold; and displaying a cautery indicator when the tip of the cryoprobe is greater than or equal to the cautery temperature threshold.

A device includes at least one first element in operative relation to at least one target tissue from a set of target tissues to treat sleep disordered breathing, which may include obstructive sleep apnea. The operative relation may include sensing and / or stimulation. The at least one target tissue may comprise diaphragm-related tissue, respiratory tissue-related nerves, and / or upper airway patency-related tissue. Example tissue in the set of target tissues includes hypoglossal nerve, infrahyoid muscle (IHM)-innervating nerve, IHMs, glossopharyngeal nerve, an internal superior laryngeal (iSL) nerve, phrenic nerve, diaphragm, pudendal nerve, among other nerves and muscles. In some example, multiple target tissue may be selected for stimulation and / or sensing.

The invention relates to the technical field of medical instruments, in particular to an active variable bush-hook of a cervical and lumbar surgery instrument and an application method of the active variable bush-hook. The variable bush-hook comprises a handle assembly and a variable bush-hook assembly which are connected with each other. The variable hook knife assembly comprises an angle-adjustable hook knife; by operating the handle assembly, the hooked knife can be driven to change the angle, and the cutting action on target tissue is achieved through manual force application. Through the specific structure connection and transmission design, the exposure angle of the cutting part of the hook knife can be changed, automatic resetting can be achieved, and precise, safe and active cutting of the hooked vertebra joint ligament or the posterior longitudinal ligament in the deep narrow space is achieved.

Systems, devices, and methods for delivering laser energy directed toward target tissue using a spectroscopic feedback. An exemplary laser feedback control system comprises a feedback analyzer to receive a signal from a target tissue using a spectroscopic sensor, and a laser controller to determine whether the received signal generally equals a first preset. If the received signal meets the first preset, the laser controller can send a control signal to a laser system to change from a first state to a second state of the first laser system. The laser system can deliver laser energy via an optical fiber towards the target tissue.

The invention relates to the technical field of image guidance positioning, and provides a radiotherapy positioning system and a positioning structure based on image guidance, which are characterized in that a comprehensive, accurate and adaptive radiotherapy positioning system is constructed, the positioning structure is monitored and analyzed in real time from multi-modal image data fusion in combination with physiological features of target tissues, and the positioning structure is used for positioning the target tissues. In the radiotherapy process, parameters of the treatment bed and the positioning structure can be dynamically and accurately adjusted according to the actual position and state change of the target tissue, the integration mode effectively avoids the problem of positioning deviation caused by the fact that a traditional positioning method is single and lacks real-time dynamic adjustment, and the positioning accuracy is improved. The overall precision and reliability of radiotherapy positioning are greatly improved, and a solid guarantee is provided for accurate action of radiotherapy on target tissues.

A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.

An implantable system for compressing internal tissue within a host body includes a compressing member and a stricture member made up of several interactive components for compressing internal tissue that could include a body canal which is a conduit for the flow of internal or external materials including fluids or solids or just a targeted tissue mass within the host body. The compressing aspect, including the stricture member, can also act to alternatively release said compression on the targeted tissue. In creating compression, the compressing aspect moves against the stricture member while reversing the compression is accomplished by reversing the process. An actuator, controlled by internal or remote electronic signals acts to move the compressing member.

A light based system for treating an eye includes a mask that is configured for positioning on the eye and a light source that is configured to deliver therapeutic light. The mask has an inner surface that is positionable against the eye and an outer surface that is opposite the inner surface. The mask is optically opaque to prevent transmission of light through the mask and the mask includes at least one transparent opening that allows transmission of light through the mask to target tissue of the eye posterior the transparent opening. The light source is positioned relative to the mask so that the delivered therapeutic light irradiates at least a portion of the mask and the transparent opening. Therapeutic light traverses through the transparent opening to the target tissue positioned posterior the transparent opening.

To provide a catheter capable of suppressing damage to a non-target tissue and preventing a medicine from falling off.SOLUTION: A catheter includes a first shaft 10, a second shaft, and a balloon having an expandable part 31 capable of adjusting a protrusion length of the expandable part 31 from the first shaft 10 according to the length of a lesioned part of a patient. The balloon includes a medicine layer 35 arranged on an outer surface of the expandable part 31. The expandable part 31 includes a balloon body part 33 and a convex part 32 protruding outward in a radial direction of the balloon body part 33. The balloon includes a wing part 34 in a deflated state, and an outermost end 32t of the convex part 32 is positioned more outward in the radial direction than an outermost end 34t of the wing part 34 in the deflated state, The convex part 32 includes a first region present closer on a proximal side than a distal end of the first shaft 10, and in the first region, the convex part 32 comes in contact with an inner wall of the first shaft 10.SELECTED DRAWING: Figure 9

The present disclosure describes systems and methods for cell therapy. Cells (e.g., stem cells, immune cells, cardiomyocytes, etc.) may be engineered to exhibit extended half-lives as compared to control cells (e.g., non-engineered cells). The cells may be engineered to exhibit increased proliferative activity as compared to control cells. In some embodiments, immune cells may be engineered to efficiently and specifically target diseased cells (e.g., cancer cells) while control cells are insufficient or unable to target the diseased cells. In some embodiments, stem cells or differentiated cells, such as myocardial cells, may be administered to a target tissue for enhanced tissue engineering or regenerative medicine. The engineered cells disclosed herein can be engineered ex vivo, in vitro, and in some embodiments in vivo. Engineered cells prepared ex vivo or in vitro may be administered to a subject in need thereof to treat a disease (e.g., myeloma or solid tumor). The engineered cell may be autologous to the subject. Alternatively, the engineered cell may also be allogeneic to the subject.