2700 results about "Target tissue" patented technology

The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

Systems, devices, and methods for performing a cosmetic procedure on a patient are provided herein. A system includes at least one treatment device. Each treatment device having a set of multiple treatment modules. Each treatment module having at least one coring element and at least one actuation assembly. Each actuation assembly being operably attached to at least one treatment module of the set of multiple treatment modules and performing a microcoring procedure that includes the attached treatment module translating in a series of reciprocating motions. Each reciprocating motion includes each coring element of the attached treatment module being inserted into and withdrawn from target tissue of a patient.

The invention discloses a drug resistance prediction method and system based on comparative learning and multi-modal fusion, and the method comprises the steps: firstly generating a molecular map and a molecular fingerprint based on the SMILES of a target drug, and extracting the molecular features of the drug through a comparative learning model constructed through combining a map attention network and a map convolution network; and then, acquiring protein expression, gene expression and metabolic expression data from the target tissue cells, extracting modal features through a deep convolutional network, a Transform encoder and a multi-dimensional attention network, and realizing adaptive fusion of the multi-modal features through a heterogeneous interactive attention mechanism. And finally, jointly inputting the fused multi-modal features and drug molecular features into a multi-layer sensor to realize high-precision prediction of the drug resistance of cells to drugs. By introducing a contrast learning and multi-modal feature fusion mechanism, the characterization capability and prediction precision of the model are effectively improved, and efficient and reliable support can be provided for drug screening and clinical decision making.

The invention discloses a flexible neural electrode and a preparation method thereof. The flexible neural electrode comprises a near-end contact part, a middle-section contact part, a lead connecting part and a far-end electrode part which are sequentially arranged in the implanting direction of target tissue. The near-end contact part is configured to be located outside the target tissue; the middle section contact part, the lead connecting part and the far-end electrode part are all configured to be located in the target tissue; the far-end electrode part is electrically connected with the middle section contact part and the near-end contact part through the lead connecting part. The near-end contact part is provided with a structure which is electrically connected with external equipment, and the external equipment is configured to be positioned outside the target tissue; the middle contact portion has a structure that forms an electrical connection with an internal device, and the internal device is configured to be located inside the target tissue. By adopting the flexible neural electrode provided by the embodiment of the invention, the treatment process can be simplified, and the operation times of a patient are reduced, so that the operation risk and the medical cost are reduced.

Disclosed herein are implantable intraocular drug delivery devices structured to provide targeted and / or controlled release of a drug to a desired intraocular target tissue, and methods of implanting and methods of using such devices for the treatment of ocular diseases and disorders. In certain embodiments, some, most, or essentially all of the device is made of biodegradable materials.

The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.

A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.

An apparatus includes a catheter assembly and an end effector. The catheter assembly includes an outer sheath with a distal end. The end effector is associated with a distal end of the catheter assembly. The end effector includes a panel assembly with microelectrodes for electrophysiological (EP) mapping. The microelectrodes are configured in a matrix within the panel assembly and provide multiple points of contact with the target tissue for EP mapping. The panel assembly can transition between a first contracted state and a second expanded state. The panel assembly can fit within the outer sheath in the first state. The panel assembly can expand outwardly away from a longitudinal axis defined by the catheter assembly in the second state once exposed distally relative to the distal end of the outer sheath.

The embodiment of the invention discloses an endoscope image processing method and an endoscope system thereof, and the method comprises the steps: obtaining a to-be-processed endoscope image and at least one frame of historical endoscope image, then recognizing a surgical instrument image in the to-be-processed endoscope image, enabling at least a part of target tissue to be shielded by the surgical instrument image, and then carrying out the recognition of the surgical instrument image in the to-be-processed endoscope image, the method comprises the following steps: determining a target tissue image which is not shielded by a surgical instrument in at least one frame of historical endoscope image, finally performing fusion processing on a to-be-processed endoscope image and the target tissue image to obtain a target endoscope image, and displaying the target endoscope image, different blocks in the surgical instrument image are subjected to transparency processing of different degrees, the transparency of the blocks closer to the edge of the surgical instrument is lower, the overall real contour of the surgical instrument can be clearly observed, meanwhile, the target tissue can be more remarkably observed in the central area of the surgical instrument, and the surgical instrument can be more accurately observed. And the overall display effect of the endoscope image is improved.

The invention discloses a skin targeted therapy laser control method and system based on a dual-wavelength synergistic effect, and the method comprises the steps: collecting the real-time morphological characteristics and pigment distribution data of skin tissues through a multispectral imaging unit, and recognizing the optical characteristic parameters of a target treatment region; generating a dual-wavelength combination scheme through a dynamic wavelength selection algorithm based on the optical characteristic parameters and the tissue structure characteristics of the target treatment area; according to a dual-wavelength combination scheme, generating a synergistic laser sequence with a specific pulse interval and energy ratio; the synergistic laser sequence is converted into a driving signal, and a dual-wavelength laser is controlled to output composite laser; and laser output parameters are dynamically adjusted through real-time thermal diffusion monitoring and an optical feedback mechanism. By utilizing the embodiment of the invention, accurate and selective heat dissipation of skin target tissues can be realized, surrounding normal tissues are effectively protected, the treatment safety and effectiveness are improved, and side effects are reduced.

The invention discloses a photoacoustic imaging method and a photoacoustic imaging system, and the method comprises the steps: obtaining the ultrasonic image data of an imaging target, and determining the biological tissue type of the imaging target based on the features of the ultrasonic image data; a luminous flux distribution result corresponding to the biological tissue type is determined, and the luminous flux distribution result is generated after a simulation target tissue corresponding to the biological tissue type of the imaging target is irradiated by laser in the simulation imaging process of the simulation target tissue; the light source is used for representing luminous flux distribution conditions of biological tissues relative to the body surface under different imaging depths; obtaining photoacoustic image data of the imaging target; determining compensation parameters of the photoacoustic image data based on the luminous flux distribution result; compensating the photoacoustic image data based on the compensation parameter to obtain compensated photoacoustic image data; and generating a photoacoustic image according to the compensated photoacoustic image data. According to the invention, the quality and precision of the photoacoustic image can be improved.

A microcatheter with a guidewire therein can be steered to target tissue, then the target tissue can be punctured with the guidewire to create a transseptal puncture. The microcatheter can have a diameter substantially smaller than known sheaths which are typically used to guide a needle to a target puncture site in known transseptal puncture treatments. The guidewire can have an atraumatic, electrically conductive distal end that can be electrically energized to puncture the target tissue. Once the guide wire is across, ancillary devices such as a dilator and sheath can be delivered over the guide wire across the transseptal puncture. The microcatheter can include one or more location sensors. A navigation module can use the electrically conductive distal end as a reference electrode to the location sensor(s) of the microcatheter.

A device for treating a diseased native valve in a patient is provided, the device including a frame structure and a plurality of leaflets. The device can further include a spiral anchor configured to extend around an outer circumference of the frame structure. The anchor can be configured to deliver a contrast agent into or near a target tissue. Other embodiments and methods of use are also provided.

One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source. The neuromuscular stimulator can include a controller and at least one electrode. The controller can be configured to receive certain power and stimulation parameters associated with a therapy signal from the power source. The at least one electrode can be configured to deliver the therapy signal to a target tissue associated with control of a posterior base of the tongue of the subject.

Embodiments of the present invention are directed to the treatment of hypertension, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pains, asthma, pulmonary arterial hypertension, and chronic obstructive pulmonary disease by delivering of an effective amount of formulations at desired temperature to target tissue. The formulations include gases, vapors, liquids, solutions, emulsions and suspensions of one or more ingredients. The temperature may enhance safety and efficacy of the formulations for the treatments. The amounts of the formulation and / or energy are effective to injury or damage the tissues to have a benefit of symptom relive.

The invention relates to the field of medical physics, and discloses a control method and system for pulse electric field ablation of duodenum, and the method comprises the steps: determining a multi-target tissue, needing pulse electric field ablation, of the duodenum corresponding to a target user, collecting a target tissue image of the multi-target tissue, and constructing a multi-tissue three-dimensional model of the multi-target tissue; analyzing tissue parameters of the multi-target tissue, and analyzing electric field intensity and pulse parameters required for ablation of the multi-target tissue; multiple electrodes of the ablation equipment are configured, and multiple electrode implantation sites of the multiple electrodes are determined; constructing a digestive tract model from the corresponding oral cavity to the duodenum of a target user, analyzing an ideal transmission path of multiple electrodes, analyzing a path deviation coefficient of a simulation transmission path and the ideal transmission path, correcting the simulation transmission path, transmitting the multiple electrodes to a multi-electrode implantation site, and then performing multi-electrode implantation. And pulse electric field ablation of multi-target tissues is realized by utilizing multiple electrodes. The precise ablation effect of the pulsed electric field can be improved.

The invention discloses an imaging equipment positioning guiding method, system and equipment based on sparse reconstruction, and the method comprises the steps: employing imaging equipment, and automatically collecting 2D images of a designated region of a simulation patient from a plurality of sparse angles; selecting a target tissue to be modeled on the 2D image; performing 3D modeling on the selected target tissue by adopting an extremely sparse reconstruction algorithm to form a 3D modeling image of the target tissue; registering the 3D modeling image and the 2D image, and calculating a first conversion relation between a visual coordinate system and a motion coordinate system of the imaging equipment; adjusting the initial pose of the 3D modeling image, and calculating the target position of the imaging device corresponding to the adjusted pose based on the first conversion relation and the adjusted pose of the 3D modeling image; and controlling the imaging equipment to reach the target position so as to obtain an expected imaging view angle of the target tissue.

An objective of the present disclosure is to provide anti-CD137 antigen-binding molecules which have immunocyte-activating effect, cytotoxic activity, or anti-tumor activity, and meanwhile have reduced effect on non-tumor tissues such as normal tissues and produce less side effects, and methods of using the same.Anti-CD137 antigen-binding molecules which have immunocyte-activating effect, cytotoxic activity, or anti-tumor activity, and meanwhile have reduced effect on non-tumor tissues such as normal tissues and produce less side effects, are provided by discovering and producing CD137 antigen-binding molecules whose binding activity to CD137 depends on various substances (for example, small molecule compounds) in target tissues. Methods of using the same, pharmaceutical formulations, and such are also provided.The present disclosure also provides an antigen-binding molecule whose binding activity to an antigen varies depending on a small molecule compound, a preparation method thereof, and uses thereof.

The inventions provided herein relate to injection applicators, tissue markers and uses thereof, e.g., to mark a target tissue site (e.g., a biopsy site in a breast tissue) or to produce a cell scaffold. The tissue markers described herein are designed to be resistant to fast migration (e.g., immediate migration after implantation through a needle track) and slow migration (e.g., over an extended period of time) upon implantation at a target tissue site (e.g., a biopsy site in a breast tissue), without using an adhesive. Additionally or alternatively, the tissue markers described herein can be readily detectable by at least one imaging modality, e.g., but not limited to magnetic resonance imaging, X-ray imaging, ultrasound imaging, or a combination thereof.

Treatment of damaged, diseased, abnormal, obstructive, cancerous or undesired tissue (e.g. a tumor, a benign tumor, a malignant tumor, a cyst, or an area of diseased tissue, etc) is provided by delivering specialized pulsed electric field energy to target tissue areas in a specific dose so as to obtain a superior outcome. The specialized PEF energy and delivery has been optimized to provide advanced treatment of target tissue areas, including destruction of undesired tissue and generation of improved inflammatory and immune responses. The specialized PEF energy provides superior outcomes to radiofrequency ablation and irreversible electroporation.

The invention relates to the technical field of ultrasonic scanning imaging, and discloses an ultrasonic robot real-time trajectory planning method and system based on an ultrasonic image. The trajectory planning method is applied to the ultrasonic scanning robot and specifically comprises the following steps that S101, an area where a target tissue is located is obtained, continuous scanning is carried out, an image of a cross section is obtained in real time, meanwhile, preliminary positioning of an ultrasonic probe is completed, and each frame of collected image and posture data of a current mechanical arm are synchronously recorded; and S102, carrying out image segmentation processing on the obtained image of the cross section, identifying a target structure region represented in each frame of image, accurately separating the target structure region from a complex background, obtaining the target segmentation of each frame of image, and then entering a spatial modeling stage. According to the method, the quality and robustness of the ultrasonic diagnosis image are improved by using the advantages of high learning efficiency and good generalization of the deep learning model, and the problem of poor online real-time adjustment capability in the current ultrasonic detection technology is solved.

An apparatus includes a catheter assembly and an end effector. The catheter assembly includes an outer sheath with a distal end. The end effector is associated with a distal end of the catheter assembly. The end effector includes a panel assembly with microelectrodes for electrophysiological (EP) mapping. The microelectrodes are configured in a matrix within the panel assembly and provide multiple points of contact with the target tissue for EP mapping. The panel assembly can transition between a first contracted state and a second expanded state. The panel assembly can fit within the outer sheath in the first state. The panel assembly can expand outwardly away from a longitudinal axis defined by the catheter assembly in the second state once exposed distally relative to the distal end of the outer sheath.

The invention relates to a photoacoustic-OCT (optical coherence tomography) bimodal endoscopic imaging system based on multi-element focusing. The photoacoustic-OCT bimodal endoscopic imaging system comprises a signal control module, an optical coherence tomography module, a photoacoustic signal excitation module, a light beam common-path module, an endoscope probe, a rotary withdrawing module and a data acquisition module, a sample arm of the optical coherence tomography module and the photoacoustic signal excitation module enter the endoscope probe through the light beam common-path module; an optical assembly and a photoacoustic receiver are arranged in the endoscope probe, and the optical assembly focuses OCT and photoacoustic combined laser and then irradiates target tissue with the focused OCT and photoacoustic combined laser; an ultrasonic signal generated after the target tissue is irradiated by the pulse laser is received by the photoacoustic signal receiver and converted into an ultrasonic electric signal, and the ultrasonic electric signal is sent to the data acquisition module; the rotation withdrawing module controls the endoscope probe to conduct three-dimensional body data scanning, and the data collecting module receives OCT interference signals and ultrasonic electric signals of the opto-acoustic receiver. Compared with the prior art, the device has the advantages of large working distance, high resolution and less influence by water.

A system to configure a neurostimulation signal to a patient's body has a neurostimulator to create a base stimulation signal which has a series of first pulses. A computer processor within the neurostimulator deconstructs the first series of pulses into a first and second partial pulse series which have respective first and second partial electrical pulses where the first and second partial electrical pulses substantially summate to the base stimulation signal. A programmable signal generator provides a constant amplitude of combined stimulation pulses by applying the first and second partial pulses to a number of contacts of an electrode positionally located to stimulate a target tissue in the patient's body.

Provided herein are systems, devices, and methods for treating tissue of a patient. The system includes a first energy delivery device having a first energy delivery element to be positioned proximate target tissue of the patient, a second energy delivery element, an energy delivery console to provide energy between the first energy delivery element and the second energy delivery element, and a user interface having a display for providing information to a user. The energy provided by the energy delivery console creates one or more electric fields within an energy delivery volume proximate the first energy delivery element, and at least one electric field within the energy delivery volume is sufficient to irreversibly electroporate target tissue within the energy delivery volume.

According to various embodiments, machine learning techniques for determining a pharmacokinetic parameter of a radiotracer in a patient are presented. The techniques include: obtaining a time sequence of positron emission tomography (PET) scans of a target tissue of the patient, where the time sequence of PET scans includes images of a radiotracer in the target tissue; providing the time series of the PET scans to a first neural network system, which provides features extracted from the time series of the PET scans; providing the features extracted from the time series of the PET scans to a second neural network system, which provides an estimated arterial input function; modeling the pharmacokinetic parameter of the radiotracer based on the estimated arterial input function and the time sequence of PET scans; and outputting an estimate of the pharmacokinetic parameter of the radiotracer based on the modeling.

Devices and methods are disclosed for treating tissue with microwave energy. Such devices and methods are able to treat cavities or surface tissue by creating one or more area or volumetric lesions. Also disclosed are flexible, low-profile devices that can be inserted non-invasively or minimally invasively near or into the target tissue as well as microwave antennas designed to generate ablation profiles that can ablate a large area or a large volume of target tissue in a single ablation. The devices include antennas wherein the field profile generated by an antenna is tailored and optimized for a particular clinical application. The antennas use unique properties of microwaves such as interaction of a microwave field with a metallic object and the use of additional shaping elements to shape the microwave field.

A system for treating a target tissue of a patient comprises a first robotic arm coupled to a treatment probe for treating the target tissue of the patient, and a second robotic arm coupled to an imaging probe for imaging the target tissue of the patient. The system further comprises one or more computing devices operably coupled with the first robotic arm and the second robotic arm, the one or more computing devices configured to execute instructions for controlling movement of one or more of the first robotic arm or the second robotic arm. The treatment probe and / or the imaging probe is constrained to be moved only within an allowable range of motion.

Surgical systems and methods for tracking physical objects near a target site during a surgical procedure are provided, the surgical system employs a navigation system and a surgical instrument; an instrument tracker is provided on the surgical instrument and a patient tracker is provided on the patient's target tissue; the system and method is configured to detect an error condition compromising accuracy of the navigation guidance and to track and monitor a tool-to-bone offset.