37 results about "Tissue volume" patented technology

A method for cross-referencing of 2D ultrasound scans of a tissue volume comprises generating first and second 2D representations of a target anatomy, respectively, from first and second series of 2D ultrasound images of the tissue volume generated. The method includes generating first and second simulated 2D representations of the target anatomy, respectively, from the second and first series of 2D ultrasound images. The 2D and simulated 2D representations are processed to at least substantially match pixel positions in the 2D and simulated 2D representations associated with the target anatomy. The method includes determining first and second correspondence transformation matrices from the processed 2D and simulated 2D representations, and using the first and second correspondence transformation matrices to determine, for a location in the second series of 2D ultrasound images associated with the target anatomy, a corresponding location in the first series of 2D ultrasound images.

The application discloses a percutaneous lung puncture path planning method and device based on lung segment level blood vessel structure constraint, and the method comprises the following steps: performing isotropic resampling, lung lobe segmentation and bronchial tree extraction on CT image data to generate a three-dimensional lung dissection model; inputting the three-dimensional lung dissection model into a lung segment semantic segmentation module to output a lung segment boundary; reconstructing the topological connection relationship between lung segment level blood supply arteries and drainage veins from the lung segment boundary to obtain a structured lung segment level blood vessel atlas; constructing a dynamic puncture risk field voxel map according to the structured lung segment level blood vessel atlas; sampling a plurality of candidate needle entry points in a surface feasible needle entry region to generate an initial path set in the three-dimensional lung dissection model; and weighting the path length, cumulative risk value, puncture angle penalty and high-density lung tissue volume according to a multi-objective optimization function to output a final puncture path. The application significantly improves the safety boundary and clinical applicability of percutaneous lung puncture.

A system for treating fat tissue, including: an ultrasound applicator, including: two or more ultrasound transducers configured to generate and direct ultrasonic waves to a selected tissue volume including fat tissue; a control unit, including: a control circuitry electrically connected to the two or more ultrasound transducers, wherein the control circuitry is configured to activate the two or more ultrasound transducers to heat the selected tissue volume.

A system for treating fat tissue, including: an ultrasound applicator, including: two or more ultrasound transducers configured to generate and direct ultrasonic waves to a selected tissue volume including fat tissue; a control unit, including: a control circuitry electrically connected to the two or more ultrasound transducers, wherein the control circuitry is configured to activate the two or more ultrasound transducers to heat the selected tissue volume.

In a method for obtaining a first length from a first two-dimensional image (71) representing a cross-section of a three-dimensional tissue volume at a first time, and a second length from a second two-dimensional image (81) representing a cross-section of a three-dimensional tissue volume at a second time, a first point (61.1) and a second point (61.2) are marked in the first two-dimensional image (71). Next, a third piece of data relating to the first two-dimensional image (71) is obtained. A fourth point (61.4) and a fifth point (61.5) are marked in the second two-dimensional image (81), and a sixth piece of data relating to the second two-dimensional image (81) is obtained. The marked first, second, fourth, and fifth points (61.1, 61.2, 61.4, 61.5), along with the third and sixth data, are used to check whether the positions and orientations of the first two-dimensional image (71) and the second two-dimensional image (72) match sufficiently. If they match, the first length is determined from the marked first and second points (61.1, 61.2) and the third data, and the second length is determined from the marked fourth and fifth points (61.4, 61.5) and the sixth data. In particular, the third and sixth data are obtained by marking the third point (61.3) and the sixth point (61.6), respectively. The third point (61.3) and the sixth point (61.6) may correspond to physiological landmarks visible in the first image (71) and the second image (81), respectively.

Some embodiments of the invention relate to an applicator for applying ultrasound energy to a tissue volume, comprising: an array comprising a plurality of ultrasound transducers, the transducers arranged side by side, the transducers configured to emit unfocused ultrasound energy suitable to thermally damage at least a portion of the tissue volume, each of the transducers comprising a coating thin enough so as not to substantially affect heat transfer via the coating to the tissue; and a cooling module configured to apply cooling via the transducers to prevent overheating of a surface of the tissue volume being contacted by the transducers.

A catheter and patch electrode system is provided for use with an ablation generator, having a 4-wire interface for improved impedance measurement. The 4-wire interface includes a pair of source connectors across which an excitation signal is produced and a pair of sense connector wires across which the impedance is measured. The system further includes a cable that connects the generator to a catheter that includes a shaft with an ablation tip electrode disposed at a distal end. The impedance sensor circuit produces an excitation signal across the source connectors, which is then carried to the catheter by the cable, then to the tip electrode, travels through the complex load (tissue volume), and returns to the generator via a patch electrode. The impedance is measured by observing the voltage drop across the sense connectors caused by the excitation signal.

A magnetic resonant imaging (MRI) review workstation includes a control processor, and a display integrated or otherwise operatively coupled with the control processor, wherein the control processor is configured to receive and analyze magnetic resonant imaging information pertaining to an imaged volume of tissue, and to cause to be displayed on the display output information that reflects or is otherwise indicative of an absorption rate of a contrast agent in the volume of tissue.

A method for cross-referencing of 2D ultrasound scans of a tissue volume comprises generating first and second 2D representations of a target anatomy, respectively, from first and second series of 2D ultrasound images of the tissue volume generated. The method includes generating first and second simulated 2D representations of the target anatomy, respectively, from the second and first series of 2D ultrasound images. The 2D and simulated 2D representations are processed to at least substantially match pixel positions in the 2D and simulated 2D representations associated with the target anatomy. The method includes determining first and second correspondence transformation matrices from the processed 2D and simulated 2D representations, and using the first and second correspondence transformation matrices to determine, for a location in the second series of 2D ultrasound images associated with the target anatomy, a corresponding location in the first series of 2D ultrasound images.

Some embodiments of the invention relate to an applicator for applying ultrasound energy to a tissue volume, comprising: an array comprising a plurality of ultrasound transducers, the transducers arranged side by side, the transducers configured to emit unfocused ultrasound energy suitable to thermally damage at least a portion of the tissue volume, each of the transducers comprising a coating thin enough so as not to substantially affect heat transfer via the coating to the tissue; and a cooling module configured to apply cooling via the transducers to prevent overheating of a surface of the tissue volume being contacted by the transducers.

The present invention relates to devices, systems and methods for determining a blood perfusion value of a subject, as well as suitable sensors. The apparatus comprises circuitry configured to: obtain a photoplethysmography (PPG) signal acquired by a sensor comprising a light emitter and a light detector at a measurement location of a subject; determining the modulation depth of the obtained PPG signal; and determining the determined depth of modulation by or from the depth of modulation based on measurement-related information indicative of the length of the optical path of light through the tissue of the subject from the light emitter to the light detector and / or the tissue volume of the tissue of the subject through which the light passes from the light emitter to the light detector The perfusion index is normalized to determine a blood perfusion value of the subject.

Some embodiments of the invention relate to an applicator for applying ultrasound energy to a tissue volume, comprising:an array comprising a plurality of ultrasound transducers, the transducers arranged side by side, the transducers configured to emit unfocused ultrasound energy suitable to thermally damage at least a portion of the tissue volume, each of the transducers comprising a coating thin enough so as not to substantially affect heat transfer via the coating to the tissue; anda cooling module configured to apply cooling via the transducers to prevent overheating of a surface of the tissue volume being contacted by the transducers.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. Treatment planning systems are also provided for preparing and implementing a digital treatment plan. The treatment planning can include dividing a target tissue volume into a plurality of treatment locations, and controlling the speed, and pattern of movement between these tissue locations.

A laser therapy device comprises a pulsed laser light source. Each triggering of tissue irradiation causes application of a first heating laser pulse of a first power and a first pulse duration and at least a second heating laser pulse of a second power and a second pulse duration to the tissue. Changes in volume resulting from the rising and the decreasing power gradient of the first laser pulse are detected. The therapy device, on the basis of the measured values relative to the change in volume and taking into consideration at least the predetermined rises of the power gradients of the first heating laser pulse, determines an estimated value for the temperature increase in the tissue during irradiation of the first heating laser pulse, and generates, from the estimated value, a command that causes adjustment of the second power and / or the second pulse duration of the second laser pulse.

The invention relates to the technical field of facial filling agents, and particularly discloses a facial filling agent containing polylactic acid microspheres and sodium hyaluronate and a preparation method of the facial filling agent. The preparation method comprises the following steps: preparing polylactic acid microspheres by adopting an emulsification-solvent evaporation method, compounding the polylactic acid microspheres with sodium hyaluronate, a mannitol compound and the like by adopting a freeze-drying technology, and finally performing irradiation sterilization to ensure that the polylactic acid microspheres are sterile. The long-term beautifying effects of filling wrinkles, supplementing tissue volume and improving facial skin are achieved through the contained polylactic acid microspheres for stimulating autologous collagen regeneration and the instant filling effect of sodium hyaluronate. And side reactions are reduced through the mannitol compound, and the onset time is shortened.

A method for providing a plyometric exercise to a subject, including: selecting at least one target region of interest (RO I) in a subject body for a plyometric exercise; positioning at least 2 electrodes above a tissue volume at the selected target ROI; generating at least one electric field by at least one pulse generator electrically coupled to the at least 2 electrodes; delivering the at least one electric field between the at least 2 electrodes to the tissue volume with parameter values selected for contracting at least one muscle in the tissue volume as part of a plyometric exercise of the at least one muscle.

This invention provides the application of Neoruscogenin in the preparation of anti-osteoporosis drugs, belonging to the field of pharmaceutical biotechnology. It was found that Neoruscogenin can significantly increase bone volume fraction, bone surface area to tissue volume ratio, bone mineral density, trabecular bone number, and trabecular bone thickness in osteoporotic mice, while significantly reducing trabecular bone separation; that is, Neoruscogenin can alleviate low bone mass in postmenopausal osteoporotic mice. Furthermore, Neoruscogenin treatment for 8 weeks did not significantly affect the major organs of mice, suggesting the biocompatibility of Neoruscogenin.

A method includes generating a series of two-dimensional (2D) ultrasound images of a tissue volume associated with a plurality of positions, respectively, along a scanning direction of the tissue volume. The method includes, for a pair of consecutive 2D ultrasound images, using a deep neural network to classify a difference between the pair of consecutive 2D ultrasound images of the series of 2D ultrasound images. The deep neural network is trained to classify differences between images based on one of a plurality of predefined classes. The method includes modifying a number of 2D ultrasound images in the series of 2D ultrasound images based on the classification of the difference between the pair of consecutive 2D ultrasound images of the series of 2D ultrasound images, thereby producing a modified series of 2D ultrasound images. The method includes performing a measurement of tissue using the modified series of 2D ultrasound images.

A magnetic resonance guided focused ultrasound (MRgFUS) system for treatment of neck pain of a patient can include a head support brace, an ultrasound transducer assembly, an acoustic coupling assembly, and a positioning gantry. The head support brace includes a conformal neck cradle having an ultrasound access opening. At least one imaging MRI coil can be oriented to allow imaging of a target tissue volume. The ultrasound transducer assembly includes a focused ultrasound transducer capable of producing a focused ultrasound and oriented to direct the focused ultrasound through the ultrasound access opening. The acoustic coupling assembly includes a conformable fluid enclosure housing a volume of ultrasound transparent liquid and adapted to transmit the focused ultrasound from the focused ultrasound transducer to skin of the patient. The positioning gantry is operatively connected to the ultrasound transducer assembly and adapted to translate the ultrasound assembly in at least one direction relative to the patient.

A “localizable” systemic gene therapy system is provided substantially increasing the transfection efficiency of the gene vectors into targeted tissue cells and substantially reducing the escape of the gene vectors from the targeted tissue volume, such as would waste the vectors, promote undesired immune reactions, and / or incur prohibitive costs for the required dose of gene-containing virus vectors. In this regard, the invention provides a means to simultaneously achieve local cell membrane permeability for virus vector transport and gene-containing vector injection in a portion of a vascularized organ. It includes a double-balloon catheter that create a finite contained volume in a blood vessel for the introduction of vectors with reduced loss along with a percutaneously inserted needle electrode providing increased cell membrane permeability for virus vector transport of the cells by creating an electric field in the same location where the vectors are injected.

A system for treating fat tissue, comprising: an ultrasound applicator, comprising: two or more ultrasound transducers configured to generate and direct ultrasonic waves to a selected tissue volume comprising fat tissue; a control unit, comprising: a control circuitry electrically connected to said two or more ultrasound transducers, wherein said control circuitry is configured to activate said two or more ultrasound transducers to heat said selected tissue volume.

Some embodiments of the invention relate to an applicator for applying ultrasound energy to a tissue volume, comprising: an array comprising a plurality of ultrasound transducers, the transducers arranged side by side, the transducers configured to emit unfocused ultrasound energy suitable to thermally damage at least a portion of the tissue volume, each of the transducers comprising a coating thin enough so as not to substantially affect heat transfer via the coating to the tissue; and a cooling module configured to apply cooling via the transducers to prevent overheating of a surface of the tissue volume being contacted by the transducers.

A system for treating fat tissue, including:an ultrasound applicator, including:two or more ultrasound transducers configured to generate and direct ultrasonic waves to a selected tissue volume including fat tissue;a control unit, including:a control circuitry electrically connected to the two or more ultrasound transducers, wherein the control circuitry is configured to activate the two or more ultrasound transducers to heat the selected tissue volume.

A method of analyzing an image of a volume of tissue to determine a risk of developing breast cancer using a volume averaged sound speed within the volume. A method of determining a response to a treatment plan by determining a volume and a volume averaged sound speed of a region of interest within a volume of breast tissue and generating a combined metric from the volume and the volume averaged sound speed over the plurality of instances of time. A method of analyzing an image of a volume of tissue of a breast by applying a spatial filter to at least one ultrasound tomography image at the computing system and generating a stiffness map from the at least one ultrasound tomography image.

Some embodiments of the invention relate to an applicator for applying ultrasound energy to a tissue volume, comprising: an array comprising a plurality of ultrasound transducers, the transducers arranged side by side, the transducers configured to emit unfocused ultrasound energy suitable to thermally damage at least a portion of the tissue volume, each of the transducers comprising a coating thin enough so as not to substantially affect heat transfer via the coating to the tissue; anda cooling module configured to apply cooling via the transducers to prevent overheating of a surface of the tissue volume being contacted by the transducers.

A method of quantifying a 3D fractional moving blood volume (3D-FMBV) in a tissue volume of a subject uses an ultrasound system. The method includes acquiring images of the tissue volume from a power Doppler scan of the tissue volume, applying image enhancement settings to the images, segmenting an organ, tissue or region thereof from the image data, determining geometric partitions of the segments based on distance from the transducer head of the ultrasound system, and computing a 3D-FMBV using a 3D-FMBV analysis algorithm from the partitions.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. Treatment planning systems are also provided for preparing and implementing a digital treatment plan. The treatment planning can include dividing a target tissue volume into a plurality of treatment locations, and controlling the speed, and pattern of movement between these tissue locations.

A system for treating fat tissue, including: an ultrasound applicator, including: two or more ultrasound transducers configured to generate and direct ultrasonic waves to a selected tissue volume including fat tissue; a control unit, including: a control circuitry electrically connected to the two or more ultrasound transducers, wherein the control circuitry is configured to activate the two or more ultrasound transducers to heat the selected tissue volume.

A system for treating fat tissue, including:an ultrasound applicator, including:two or more ultrasound transducers configured to generate and direct ultrasonic waves to a selected tissue volume including fat tissue;a control unit, including:a control circuitry electrically connected to the two or more ultrasound transducers, wherein the control circuitry is configured to activate the two or more ultrasound transducers to heat the selected tissue volume.

Systems and methods for operating a robotic manipulator coupled to an ultrasonic instrument to control movement of the ultrasonic instrument to resect a target volume of patient tissue. The ultrasonic instrument is driven with an AC drive signal that induces vibrations in a tip of the ultrasonic instrument, and is positioned so that a distal region of the tip is vibrating against a portion of the patient tissue. A characteristic of the AC drive signal is obtained when the distal region of the tip is vibrating against the tissue portion, and a determination is made of whether the tissue portion corresponds to the target volume based on the determined characteristic. The robotic manipulator is operated to control movement of the ultrasonic instrument relative to the patient tissue based on the determination.