46 results about "Hematocrit" patented technology

The embodiment of the invention provides a continuous blood oxygen monitoring system in extracorporeal circulation and a control method thereof. The continuous blood oxygen monitoring system comprises a vein sensor, an artery sensor, a blood flow sensor, an oxygen sensor, a carbon dioxide sensor, a controller and a display, the vein sensor monitors the vein blood oxygen saturation degree; the artery sensor monitors arterial oxygen saturation and hematocrit; the blood flow sensor monitors the blood flow of the artery pipeline; the oxygen sensor monitors the oxygen concentration of the oxygenator; the carbon dioxide sensor monitors the carbon dioxide concentration of the oxygenator; the display provides an interaction control, responds to a trigger operation acting on the interaction control, sends an interaction instruction to the controller, and updates information displayed in an interaction interface according to the control of the controller; the controller receives the interaction instruction and executes processing corresponding to the interaction instruction; the processing includes controlling display information of the display; the display information comprises information corresponding to the monitoring parameters. The scheme ensures the safety and effectiveness of the treatment process.

The invention relates to the technical field of intraoperative intelligent monitoring, and particularly discloses a spinal canal debonding method and system for real-time state evaluation, and the method comprises the steps: collecting neural structure microcirculation blood flow data in real time through integrating a micro-sensing unit at a working end part of a surgical instrument, and extracting blood flow oscillation frequency and capillary hematocrit parameters; performing multi-scale signal decomposition on the blood flow oscillation frequency to obtain an energy distribution parameter, and performing dynamic mode recognition on the hematocrit data to obtain a main variation characteristic value; fusing the two characteristic parameters to generate a nervous tissue vitality index; inputting the index into a pre-trained neural network for time sequence feature analysis, and outputting a graded ischemia risk early warning signal; the operation rhythm is automatically adjusted through a decision tree control mechanism based on the early warning signal, and self-adaptive regulation and control according to the state of the nervous tissue are achieved; the technical problem that the risk of neural ischemia cannot be monitored in real time in a traditional spinal canal release operation is solved, and occult nerve injury caused by asymptomatic neural ischemia can be prevented.

The present invention relates to systems and methods for optimizing plasma collection volume. A plasma withdrawal system and a method for operating a plasma withdrawal system are provided by which the volume / weight of the anticoagulated plasma collected is optimized. In one example, a nomogram is provided that utilizes the donor hematocrit to calculate the volume / weight of raw plasma within a plasma product having a maximum volume allowed by the FDA nomogram. In a plasma withdrawal process having multiple collection phases followed by a reinfusion cycle in which concentrated red blood cells are returned to the donor, the volume of plasma product to be collected is calculated prior to the start of each collection cycle to account for the increasing hematocrit of the donor, resulting in a greater total volume of plasma product to be collected during the plasma withdrawal process.

There is disclosed a vital sign measuring device and method for obtaining an indication of a person's blood pressure via the person's finger by means of an inflatable measurement bladder adapted to contact only a portion of an underside of a finger defining a finger pad. A structure or other implement applies a downward force on a top portion of the finger opposite the finger pad. Blood pressure may be determined without the use of any electromagnetic radiation, such as miniature dynamic light sensing (mDLS). Apparatuses and methods for obtaining an indication of other vital signs, including hematocrit and total protein, are also disclosed.

The method for monitoring parameters of a patient during surgery with extracorporeal circulation serves to estimate the presence of AKI risk and comprises calculating a dynamic global index of AKI risk as a logistic regression deriving from a static AKI risk index and a dynamic index of AKI risk. The value and / or the time trend of such global index of AKI risk can be advantageously displayed on a monitor during the surgery. The dynamic AKI risk index is calculated at least on the basis of the extracorporeal circulation time, the minimum level of oxygen supply and the exposure time to oxygen supply below a critical threshold which are measured or determined repeatedly during surgery. Preferably, the dynamic AKI risk index is also calculated on the basis of the minimum mean arterial pressure during surgery and / or the maximum concentration of lactate in the blood during surgery and / or the minimum hematocrit during surgery and / or the fact that the patient has been subjected to transfusion(s) during the extracorporeal circulation.

A blood separation device includes a pump system, a separator, and a controller. The controller is programmed to execute a blood separation procedure including a red blood cell collection stage in which blood is conveyed into the separator, red blood cells are separated from the blood in the separator, and the separated red blood cells are conveyed from the separator into a collection container. The red blood cell collection stage is ended when a target volume of blood has been separated in the separator. The controller then determines a percentage of the red blood cells from the target volume of blood that have been collected in the collection container based on the volume of red blood cells and the hematocrit of the fluid in the collection container, a volumetric flow rate of pure red blood cells in the blood conveyed into the separator, and the procedure time.

The invention discloses an application of a natural product WithangatinA in preparation of erythroleukemia induced differentiation treatment drugs, the natural product WithangatinA promotes HEL and K562 cells to be transformed from malignant proliferative cells to normal megakaryocytes by inducing the cell particle size to become larger and significantly increasing multinuclear megakaryocytes and promoting expression of surface labeled molecules differentiated from megakaryocytes at the same time, and the erythroleukemia induced differentiation treatment drugs are obtained. The effect of resisting erythroleukemia is achieved. After the natural product Withangulin A is adopted for treatment, the size and the weight of the spleen of a leukemia mouse can be remarkably reduced, the hematocrit and the platelet number of the mouse are remarkably increased, in addition, treatment of the natural product Withangulin A has no obvious influence on the weight of the mouse, and the safety is high. In-vivo research shows that the medicine can induce megakaryocyte differentiation of erythroleukemia in a mouse body, the effect of resisting erythroleukemia is achieved, and a research basis is provided for development of differentiation treatment medicines of erythroleukemia.

A system includes: a dialysis system configured to provide a dialysis treatment for a patient; an optical monitoring system in communication with the dialysis system, wherein the optical monitoring system is configured to obtain measurements of the patient's hematocrit, oxygen saturation and / or blood volume change during the dialysis treatment, wherein the measurements are indicative of a double pool refill rate for the patient during the dialysis treatment; and a massaging system in communication with the dialysis system, wherein the massaging system is configured to provide massaging for the patient during the dialysis treatment, wherein providing massaging for the patient includes running a massage sequence taking into account the measurements obtained by the optical monitoring system.

The present invention relates to a method and apparatus for determining the activity of clotting factors in diluted capillary whole blood, citrated whole blood and citrated plasma. The invention also includes the detection of hemoglobin content in the whole blood sample to correct for clotting time so that the clotting time values are not affected by hemoglobin and hematocrit.

The utility model relates to medical equipment technical field discloses a kind of platelet-rich plasma separators, comprising: round plate, the outer surface of the round plate is fixedly installed with limit block.This kind of platelet-rich plasma separator, due to the design of movement mechanism, reach the flexible adjustment effect of centrifugal radius without replacing centrifugal cup, can be according to different patient blood viscosity, hematocrit and other indexes, accurately control centrifugal force, avoid platelet residue or excessive activation, significantly improve platelet-rich plasma preparation quality and biological activity.Discard the cumbersome operation of traditional replacement centrifugal cup, substantially improve operation efficiency, while reducing the mismatch risk caused by frequent replacement of spare parts, reduce the operation burden of medical staff, reduce equipment spare parts procurement cost and management difficulty, effectively improve the versatility and utilization of equipment, reduce hospital equipment procurement and maintenance cost.

The application discloses a multi-association coagulation time detection instrument and reagent card, and relates to the field of medical devices.The instrument comprises an instrument body, a reagent card channel for reagent card insertion, a first sensor and a second sensor arranged on the instrument body, the first sensor being used for detecting one end of a test channel on the reagent card, and the second sensor being used for detecting a waste liquid channel of the reagent card; a driving module, which is in communication with the waste liquid channel and the test channel respectively; and a control processing unit, which is in signal connection with the driving module, the first sensor and the second sensor respectively.After the above-mentioned instrument is used, a plurality of coagulation items can be tested at a time, each test channel can individually and accurately quantify a sample, and the blood sample and the reagent can be effectively mixed, so that the sample in the test channel can be prevented from being sucked into an air path, the waste liquid sample in the waste liquid channel can be prevented from flowing back, whether the added sample is excessive or insufficient can be detected, and the hematocrit of blood can be accurately detected.

Disclosed are methods, materials and devices for approximation of blood volume in a fluid, such as in a biological fluid collected during a surgical procedure. The method and devices may include the use of an RBC flocculant, for example polyDADMAC, and an approximate blood hematocrit from the type of animal blood being evaluated, as well as a calculated RBC packing ratio corresponding to the collection device being used. Also provided is a Blood Indicator Panel (BIP), comprising a series of markings calculated from an observed red blood settlement volume, the average animal blood hematocrit, and a calculated RBC packing ratio “η” value for the collection device. A collection device with a BIP is disclosed. Pediatric (about 200 ml or 250 ml size container), adult human (about 1,000 ml-1,500 ml) and veterinary (about 500 ml-2,500 ml) collection containers are also disclosed, that include a RBC flocculant, for use in approximating blood volume in a fluid.

The invention relates to a system and a method for optimizing plasma collection volume. A plasma retrieval system and a method for operating a plasma retrieval system are provided by which the volume / weight of collected anticoagulant plasma is optimized. In one example, a nomogram is provided that utilizes the donor's hematocrit to calculate the volume / weight of raw plasma within a plasma product having a maximum volume allowed by the FDA nomogram. In a plasma extraction process having a plurality of collection phases, after which a re-infusion cycle, in which concentrated red blood cells are returned to the donor, the volume of the plasma product to be collected is calculated before each collection cycle begins to account for an increased hematocrit of the donor, and the volume of the plasma product to be collected is calculated before each collection cycle begins. Thus, the total volume of the plasma product to be collected during the plasma extraction process is larger.

A method for collecting blood components using a medical system, the method comprising: receiving data associated with a subject by the medical system, the data associated with the subject including the subject's initial hematocrit value; determining the amount of subject-specific pure component to be collected by the medical system, the amount of subject-specific pure component to be collected by the medical system being determined using the subject's hematocrit value, the subject's total blood volume, and a target change in the hematocrit value; and performing a component collection process using the medical system to collect the determined amount of subject-specific pure component.

The present application relates to the technical field of pattern recognition, in particular to a multi-type blood glucose test paper recognition system, comprising four modules of feature perception, intelligent identification, excitation execution and compensation calculation, first, collecting high-frequency impedance phase sequence, charge-discharge relaxation time constant and sample transient surge signal through intelligent sensor, using recursive graph quantitative analysis to extract coupling feature vector; then, projecting the coupling feature vector to the attribute subspace of the preset matrix library, identifying the test paper reaction mediator potential interval, enzyme layer load abundance and hematocrit non-linear coefficient, and dynamically synthesizing the target excitation waveform containing the ladder-shaped pre-polarization segment and the load modulation sampling segment; then, driving the biochemical reaction according to the identification result to capture the Faraday steady-state response current; finally, using the weight matrix to execute space charge layer correction and diffusion flux gain adjustment, and outputting the detection result. The present application realizes accurate detection of heterogeneous test paper through multi-dimensional feature identification.

The application discloses a full-spectrum analysis method for monitoring blood oxygen saturation and hematocrit in an extracorporeal circulation pipeline, and comprises the following steps: step 1, constructing a photoelectric acquisition device; step 2, performing system initialization calibration; acquiring CMOS image sensor data, photodiode sensor dark current calibration data and empty pipeline reference data; step 3, using a main control unit to control a mixed light source module and a mixed sensor module to perform time sequence synchronous acquisition; acquiring a transmission image of a visible light band and a transmission light intensity voltage of an infrared band at a fixed frame rate; step 4, pre-processing the acquired transmission image data and transmission light intensity voltage data to generate an optical characteristic map reflecting the pipeline and an optical density vector reflecting absolute light absorption; and step 5, inputting the pre-processed optical characteristic map and optical density vector into a pre-trained double-flow deep neural network model to obtain quantitative values of blood oxygen saturation and hematocrit of liquid in the pipeline.

The invention relates to the technical field of medicines, in particular to application of a pharmaceutical composition in preparation of a medicine for treating thalassemia. The invention provides a pharmaceutical composition. The pharmaceutical composition is prepared from the following components in parts by mass: 2 to 5 parts of pravastatin sodium, 1 to 2 parts of roteciterp, 7 to 11 parts of deferasirox, 7 to 11 parts of morroniside and 30 to 40 parts of phellinus igniarius general flavone extract. The pharmaceutical composition provided by the invention shows multiple clinical beneficial effects in treatment of thalassemia. In the aspect of curative effect, the composition can significantly increase the number of peripheral red blood cells, the content of hemoglobin and the hematocrit of the peripheral blood of a patient and effectively reduce the variable coefficient of the volume of the red blood cells, which indicates that the composition not only can improve the anemia state, but also can improve the stability of the quality of the red blood cells. Besides, the traditional Chinese medicine composition can obviously relieve spleen enlargement and iron overload degree and reduce the iron deposition level of the liver and the spleen, so that the traditional Chinese medicine composition has a positive effect in the aspects of relieving hemolysis related complications and organ iron toxicity.

The invention discloses efficient and portable plateau study index detection equipment and a using method thereof.The efficient and portable plateau study index detection equipment comprises a micro-fluidic chip, a blood sampling device and a portable detector, and the micro-fluidic chip is provided with a three-electrode system used for collecting sample detection signals; a hematocrit detection module, an oxyhemoglobin saturation detection module, a control and processing module and a display and interaction module are arranged in the portable detector; the three-electrode system is connected to a receiving end of the hematocrit detection module through an electric signal; the blood collection device comprises a shell, a blood collection microneedle clamped in the shell and a blood storage device inserted and slidably connected into the shell, the blood collection end of the blood collection microneedle is located outside the shell, the blood discharge end of the blood collection microneedle is located in the shell, and the blood storage device can communicate with the blood discharge end of the blood collection microneedle. According to the invention, hematocrit detection is not limited by sites, and detection of two indexes of hematocrit detection and oxyhemoglobin saturation detection can be easily completed, so that response measures can be rapidly and accurately formulated.

A method of analyzing a blood sample from a subject includes loading the blood sample into a single chamber; acquiring, via an imaging system, a stack of serial focal plane images of the blood sample from a plurality of fields of view of the chamber; creating a virtual three dimensional image of the blood sample from selected ones of the stacks of serial focal plane images; and analyzing the virtual three dimensional image to identify blood formed elements within the blood sample. Identifying blood formed elements within the blood sample may include identifying a type and amount of white blood cells, and / or identifying an amount of red blood cells and / or hematocrit, and / or identifying an amount of platelets. Identifying blood formed elements within the blood sample may include determining numbers and percentage by volume in the blood sample of one or more types of white blood cells.

The embodiment of the invention relates to the field of hematology analyzers, and discloses a hematology analyzer and a debugging method.The debugging method comprises the steps that first feature values of test standard particles of different sizes on a target hematology analyzer are obtained, and a base line of the target hematology analyzer is calculated; the first characteristic value is an abscissa value which is corresponding to the peak value of the pulse distribution histogram and is used for representing the volume of the test standard particle; calculating a particle amplification degree difference between the target hematology analyzer and the standard hematology analyzer according to the base line and the first characteristic value; and adjusting a pulse distribution histogram generated by the target hematology analyzer according to the difference between the baseline and the particle amplification degree of the target hematology analyzer, so that the measured values of the target hematology analyzer and the standard hematology analyzer for the hematohematocrit or the average hematohematocrit of the same test standard particle are consistent. According to the application, the debugging problem of the hematology analyzer is solved, and the influence of instrument hardware on the pulse measurement value is avoided.

This invention discloses the application of Huanglian Shangqing tablets combined with glucocorticoids in the preparation of drugs for treating leukemia. The Huanglian Shangqing tablets combined with glucocorticoids can inhibit the activity of Jurkat cells in a concentration-dependent manner; inhibit the proliferation of Jurkat cells in a concentration- and time-dependent manner; and significantly induce apoptosis in the human acute lymphoblastic leukemia cell line Jurkat. In animal experiments, compared with the model group, the Huanglian Shangqing tablets combined with glucocorticoids can increase the hematocrit ratio of leukemia mice, reduce the spleen burden in mice, have no obvious toxic side effects, and improve the survival rate of leukemia mice. Therefore, the Huanglian Shangqing tablets combined with glucocorticoids have the potential value of developing drugs to reverse glucocorticoid resistance in leukemia. Furthermore, Huanglian Shangqing tablets are already used clinically, which can effectively shorten the preclinical research period and has a very good application prospect.

The utility model relates to a detection device capable of correcting hematocrit. The detection device comprises a dry chemical test paper clamping shell upper cover, hematocrit detection test paper, dry chemical test paper and a dry chemical test paper clamping shell lower cover, the hematocrit detection test paper comprises a double faced adhesive tape, a hydrophilic film, a double faced adhesive tape, a hematocrit detection electrode and a double faced adhesive tape from top to bottom; the dry chemical test paper clamping shell upper cover comprises a sample adding hole; and the lower cover of the dry chemical test paper clamping shell comprises a detection hole.

The invention relates to a method for evaluating the immune state of obese people and a kit thereof, relates to the technical field of medical data mining, and comprises an index combination for evaluating the immune state of the obese people. The index combination comprises the following indexes: hematocrit (HCT), hemoglobin content (HGB), low membrane potential percentage (Ts.MMPlow%) of killer T cells, percentage (T4Tcm%) of central memory assistant T cells, low membrane potential percentage (T8Tn.MMPlow%) of pure killer T cell mitochondria, percentage (NKT.NKG2D +%) of NKT cell expression NKG2D and mitochondrial mass (T8Tcm. MM) of central memory killer T cell mitochondria. The index combination obtained through screening has high biological interpretation and clinical correlation, and the immune state of obese people can be effectively evaluated.

The invention discloses a calibration method, a standard solution and a microfluidic electrochemical chip for rapid detection of hematocrit, and the calibration method comprises the following steps: n temperature nodes are sequentially arranged from low to high, the difference value of adjacent temperature nodes is 6.5 DEG C, and the lowest temperature node is less than 0 DEG C; n altitude nodes are sequentially arranged from low to high, the difference value of the adjacent altitude nodes is 1000 meters, the lowest altitude is 0 meter, and air pressure is set corresponding to the n altitude nodes; the n temperature and altitude nodes are combined into n detection environments in a one-to-one correspondence manner; placing the standard solution in a calibration pool, and detecting electrochemical signals in n detection environments; taking air pressure and temperature as independent variables, taking the average value of the signal values as a dependent variable, and establishing a calibration curve by using a least square method; according to the invention, influence factors of altitude and temperature on detection are fully calculated, accurate calibration can be carried out on detection of the microfluidic electrochemical chip, and errors in detection are reduced, so that the accuracy of a detection result is improved.

Disclosed are methods, materials and devices for approximation of blood volume in a fluid, such as in a biological fluid collected during a surgical procedure. The method and devices include the use of a RBC flocculant, such as polyDADMAC, and an approximate blood hematocrit for the type of animal, as well as a calculated RBC packing ratio corresponding to the collection device being used. Also provided is a Blood Indicator Panel (BIP), comprising a series of markings calculated from an observed red blood settlement volume, the average animal type hematocrit, and a calculated RBC packing ratio “η” value for the collection device. Pediatric (about 200 ml or 250 ml size container), adult human (about 1,000 ml-1,500 ml) and veterinary (about 500 ml-2,500 ml) collection containers are also disclosed, that include a RBC flocculant, for use in approximating blood volume in a fluid.

An example system includes a detector configured to detect a value that is based on a hematocrit of a test sample containing plasma and red blood cells, a fluidic channel configured to hold the test sample, and an acoustic transducer configured to apply acoustic waves to the fluidic channel to separate the plasma from the red blood cells in the fluidic channel. The acoustic waves have at least one of an amplitude, a frequency, or a duration that is based on the value.

The invention discloses an animal blood cell analyzer and an animal blood cell analysis method.According to the animal blood cell analyzer, a first protein detection result is corrected based on serum detection data obtained through searching in a historical database, tedious sample pretreatment is not needed, and the operation process is simplified; the first protein detection result can be corrected based on historical serum detection data, so that the cost of specific protein detection is reduced, the first protein detection result can accurately reflect the organism state of the animal, the error value of the detection result is reduced, and the detection accuracy is improved. The problem that when an existing animal blood cell analyzer uses whole blood to conduct specific protein detection, serum detection data such as fixed hematocrit is adopted for correction, and consequently detection errors are large is solved, and the detection accuracy can be improved.

An example system includes a chamber to hold a mixture that includes a whole blood sample from a patient, a light source to illuminate the mixture in the chamber, a detector to detect light from the light source transmitted through the mixture in the chamber, and one or more processing devices to determine, based on the light detected by the detector, a platelet aggregation value of the whole blood sample that is substantially independent of a hematocrit of the whole blood sample.

The invention provides an electrochemical test strip and device for total cholesterol detection, and relates to the technical field of biological detection. The electrochemical test strip for total cholesterol detection is sequentially provided with a substrate, an electrode layer, an insulating layer, an enzyme layer and a detection sample introduction channel from bottom to top, the enzyme layer is obtained by attaching reaction liquid; the reaction liquid comprises the following components in percentage by mass: 10-20% of a high-molecular polymer, 0.4% of cholesterol esterase, 2.7% of cholesterol dehydrogenase, 0.5% of coenzyme, 0.5-3% of an electron transfer agent and the balance of a buffer solution. The electrochemical test strip provided by the invention is not influenced by oxygen partial pressure (the detection range of hematocrit is 20%-70%), the type of detected blood samples is widened, the samples can be detected without pretreatment, and the electrochemical test strip is simple to operate, high in sensitivity and high in detection speed.

An example system includes a chamber to hold a mixture that includes a whole blood sample from a patient, a light source to illuminate the mixture in the chamber, a detector to detect light from the light source transmitted through the mixture in the chamber, and one or more processing devices to determine, based on the light detected by the detector, a platelet aggregation value of the whole blood sample that is substantially independent of a hematocrit of the whole blood sample.