116 results about "Concentrations glucose" patented technology

The invention relates to the technical field of biomedical sensing and health monitoring, and discloses a noninvasive glucose detection system. The system comprises an interstitial fluid extraction device, a photoelectric sensing module and a main control circuit which are integrated on a flexible substrate. The interstitial fluid extraction device drives subcutaneous interstitial fluid to migrate to the hydrogel interface layer under the action of reverse ion electroosmosis; the photoelectric sensing module receives interstitial fluid through a hydrogel interface layer, a working electrode of the photoelectric sensing module comprises a Cu monatomic imprinting recognition layer, and imprinting holes formed by Cu monatomic sites are specifically coordinated with glucose molecules. The master control circuit controls sampling and determines the glucose concentration based on the photocurrent signal. Noninvasive sampling and monatomic imprinting photoelectric detection are fused, sampling-detection integration is achieved, and the device has the advantages of being noninvasive, painless, high in selectivity, high in interference resistance, comfortable to wear and the like and is suitable for continuous monitoring of blood glucose.

The invention relates to the crossing field of computer technology and biomedical engineering, and discloses a miniaturized intelligent blood glucose monitoring and analyzing method integrating edge computing. The method comprises the steps that glucose concentration and time sequence multi-source physiological signals are collected through a wearable sensor; performing data segmentation and multi-modal feature alignment based on the circadian rhythm; inputting the features into a lightweight student model obtained through knowledge distillation for blood glucose prediction; and the reasoning frequency is adaptively adjusted in combination with a memory feedback mechanism. The system comprises a sensing unit, a preprocessing unit, a lightweight model execution unit and a risk early warning unit. While the prediction precision is guaranteed, the model is compressed to be within 150 thousand parameters, a 512 KB on-chip memory is adapted, and low-power-consumption and high-stability end-side continuous blood glucose monitoring and early warning are achieved.

The invention provides a DNA enzyme triple-helix molecular switch detection system adaptive to a personal glucometer as well as a preparation method and application of the DNA enzyme triple-helix molecular switch detection system, and belongs to the technical field of biosensors. The DNA enzyme triple-helix molecular switch disclosed by the invention comprises an aptamer containing two nucleotide arm segments and DNA enzyme covalently coupled with a magnetic bead, two nucleotide arm segments of the aptamer and DNA enzyme form a triple helix structure; the two nucleotide arm segments comprise a nucleotide sequence SEQ ID NO.1 at the 5'end of the aptamer and a nucleotide sequence SEQ ID NO.2 at the 3 'end of the aptamer. According to the invention, the flexibility of an original aptamer is limited by using a terminal fixation strategy, the spatial conformation of the original aptamer is stabilized, the affinity of the aptamer to a target is improved, and the sensitivity of the aptamer to the target is improved by using a triple-helix molecular switch containing DNA enzyme and nano-enzyme-gold nanoparticles. Accurate and sensitive detection of trace pollutants in food is realized by measuring the reduction amplitude of the glucose concentration in the detection liquid through a household glucometer.

The invention relates to the technical field of medical detection equipment, and particularly provides a wearable sweat glucose detection system which comprises a sweat collecting and conveying unit which is provided with a sweat inlet and a sweat flow channel which are communicated with each other and is used for collecting and conveying sweat secreted by skin; the electric signal acquisition unit is arranged on the sweat flow channel, comprises a counter electrode, a working electrode and a reference electrode which are sequentially arranged along the flowing direction of sweat in the sweat flow channel, and is used for acquiring a real-time electric signal related to the glucose concentration; the working electrode comprises a porous alloy structure layer composed of platinum and nickel and a glucose oxidase layer located on the surface of the porous alloy structure layer; the signal processing unit is used for acquiring the real-time glucose concentration according to the real-time electric signal and a preset change curve of the electric signal about the glucose concentration; the system can effectively improve the sensitivity of glucose concentration detection and reduce the dosage of precious metal.

The invention relates to a system for storing or cultivating organ or tissue models and its use. The system is designed for verifying the functionality of the harvested organ or tissue models and allowing them to be processed. The system can be used for cultivating organ and / or tissue models harvested from donors and / or prepared using other techniques, such as using 3D and / or 4D bioprinting or electrospinning techniques, and comprises a chamber (2) for the organ or tissue models, which is equipped with means for measuring and adjusting the temperature of the perfusion liquid in the chamber, a perfusion liquid container (1), which is equipped with means for measuring and adjusting the temperature of the perfusion liquid therein, means (4) for measuring the glucose concentration in the perfusion liquid and adding glucose to the perfusion liquid in a metered amount, means (3) for measuring the pH of the perfusion liquid and adding a substance for adjusting the pH of the perfusion liquid in a metered amount, means for non-contact mixing of the perfusion liquid, and means for measuring and controlling the flow parameters of the perfusion liquid.

The invention discloses a corneal glucose real-time non-invasive detection system and method, and belongs to the technical field of glucose real-time non-invasive detection.The method comprises the following steps that corneal reflection spectrum, tear film thickness change and environment temperature and humidity data are obtained in real time, and spectrum compensation parameters are generated through a temperature and humidity compensation model; outputting a tear film refractive index correction value in combination with a refractive index correction model, and correcting the reflection spectrum through a combined correction formula; then, calculating a reference reflection spectrum and a deviation value based on historical data, extracting statistical characteristics, and fusing confidence to obtain a confidence factor for adjusting the deviation value; if the deviation exceeds the threshold value, replacing the corrected data with the reference data; and finally, calculating the glucose concentration according to the processed spectrum, and determining the health grade according to a preset comparison table. The high-reliability non-invasive blood glucose health monitoring closed-loop method and system are constructed through multi-source data fusion correction, intelligent deviation optimization and a confidence coefficient decision mechanism.

The invention relates to a method for monitoring host physical sign parameters on line and a multi-working electrode system. The accuracy of glucose monitoring can be improved. The method comprises the following steps: acquiring a first physical sign parameter of a host by adopting a first working electrode; acquiring a second physical sign parameter of the host by adopting a second working electrode; obtaining a target glucose concentration of the host based on the first physical sign parameter and the second physical sign parameter; the first working electrode and the second working electrode are arranged on the same substrate and can independently obtain a first physical sign parameter and a second physical sign parameter at different depths of the host tissue. The two working electrodes can effectively detect the concentrations of analytes at different depths, and by combining the sign parameters generated by the different working electrodes, a more reliable continuous monitoring result can be comprehensively obtained, and the monitoring accuracy is improved.

The invention provides a glucose hydrogel optical fiber sensor and a preparation method thereof. The glucose hydrogel optical fiber sensor comprises an optical fiber and a glucose fluorescence sensing module fixedly carried on the end face of the optical fiber. Wherein the optical fiber comprises a double-layer hydrogel optical fiber which comprises an inner fiber core and an outer cladding. The glucose fluorescence sensing module is formed by fixing a glucose fluorescence probe containing a boric acid group and a terminal amino group through a covalent reaction between the amino group and an epoxy group in the hydrogel network. The glucose hydrogel optical fiber sensor has excellent performance, high sensitivity and good selectivity, and can realize stable and real-time detection of glucose concentration in a complex physiological environment. The sensor is flexible in structure and good in biocompatibility, does not depend on enzyme reaction, and avoids the problem of signal drift caused by enzyme inactivation; meanwhile, the sensor is good in repeatability, can be integrated with other optical sensing modules to realize multi-parameter synchronous monitoring, and is suitable for long-term dynamic monitoring application in vivo.

Provided in the present application are a blood glucose monitoring method and a related apparatus. In the method, the blood glucose level at a first moment can be acquired on the basis of a glucose concentration in interstitial fluid at the first moment, a glucose concentration in the interstitial fluid within a time period before the first moment and a glucose concentration in the interstitial fluid within a time period after the first moment. In the present application, the glucose concentration in the interstitial fluid within the time period after the first moment is taken into consideration, and an additional time period is provided for the diffusion of glucose between the interstitial fluid and blood; therefore, when the blood glucose level drastically changes, the glucose concentration in the interstitial fluid more closely approximates the blood glucose level, and thus the accuracy of blood glucose monitoring can be improved.

A sensor device is adapted to detect glucose concentration in saliva of an object, and includes a conductive substrate, a polymer layer, and a carbon nanomaterial unit. The polymer layer is disposed on the conductive substrate and is made from conducting polymer. The carbon nanomaterial unit is disposed on the polymer layer and includes at least one carbon-nanotube layer. The saliva of the object is applied on the carbon nanomaterial unit and an enzyme is added to be mixed with the saliva to detect the glucose concentration in the saliva. A method for making the sensor device is also provided.

This invention discloses a green synthesis method for acid-base bifunctional molecular sieves and its application. The method constructs acid-base sites in a one-step synthesis, yielding a molecular sieve catalyst containing acid-base bifunctional sites. This molecular sieve exhibits high activity and stable performance, and can be used as a catalyst to catalyze the isomerization of glucose to fructose. It significantly improves conversion efficiency in reactions catalyzing the isomerization of high-concentration glucose to fructose or its conversion to methyl lactate. Furthermore, this synthesis method avoids the use of environmentally harmful fluorinated mineralizers and inorganic acids, solving the problems of complex, time-consuming, and environmentally unfriendly synthesis processes of existing acid-base bifunctional molecular sieves. It also addresses the issues of low reaction efficiency and low selectivity of existing catalysts in reactions catalyzing the conversion of high-concentration glucose.

The application belongs to the field of microorganisms, and particularly relates to a strain of ultrahigh molecular weight gamma-polyglutamic acid synthesis strain and application thereof. The specific technical scheme is as follows: a strain of Bacillus subtilis FB-3 is preserved in the China General Microbiological Culture Collection Center on April 29, 2022, and the preservation number is CGMCC NO. 24826. The Bacillus subtilis is inoculated into a gamma-PGA fermentation medium, and is subjected to early fermentation under the conditions of a glucose concentration of 5-20 g / L and a ventilation amount of 0.2-3 vvm for 6-18 hours. After the early fermentation is completed, the oxygen supply level in the fermentation system is adjusted in real time, and qO2 is maintained constant at 15-40 mmol / (g.h). The application provides a new strain of Bacillus subtilis, which can produce gamma-PGA with a molecular weight of up to 25000 KDa, far exceeding the existing level of the same kind of microorganism. The method provided by the application is simple to operate, can be automatically monitored and calculated, has low requirements on operators, is suitable for large-scale fermentation production of ultrahigh molecular weight gamma-PGA, and has industrial popularization and application value.

The present invention belongs to the technical field of insulin derivatives. Disclosed are a phenylboronic-acid-based insulin derivative, and a preparation method therefor and the use thereof. The provided phenylboronic-acid-based insulin derivative has a good glucose-responsive release function, wherein the phenylboronic acid group binds to a glycosyl protein to generate a phenylboronic acid ester bond, thereby generating an insulin and glycosyl protein complex in situ in blood. When the concentration of glucose in the blood is high, the glucose specifically cleaves the phenylboronic acid ester bond, thereby releasing the insulin. The provided phenylboronic-acid-based insulin derivative achieves stable and rapid glucose-responsive insulin release, which can steadily and persistently maintain the blood glucose of a diabetic subject within the normal range with almost no occurrence of hypoglycemia.

Methods and apparatus, including computer program products, are provided for processing analyte data. In some example implementations, a method may include generating glucose sensor data indicative of a host's glucose concentration using a glucose sensor; calculating a glycemic variability index (GVI) value based on the glucose sensor data; and providing output to a user responsive to the calculated glycemic variability index value. The GVI may be a ratio of a length of a line representative of the sensor data and an ideal length of the line. Related systems, methods, and articles of manufacture are also disclosed.

An agent is for inhibiting glucose uptake into red blood cells and a blood collection tube suppresses glucose concentration decrease. The agent for inhibiting glucose uptake into red blood cells includes inosine as an active ingredient. The inhibition agent can be used for suppressing a decrease in glucose concentration of whole blood collected in a blood collection tube. The blood collection tube includes inosine in an internal space. The blood collection tube can be used to measure glucose concentration in blood. The blood collection tube can further include a glycolysis inhibitor.

The invention relates to a method for improving PD-1 titer produced by Chinese hamster ovary cells. The method comprises the following steps: inoculating the Chinese hamster ovary cells into an initial culture medium for culturing; after the culture is performed for 48 hours, feeding a fed-batch culture medium every day, and maintaining the glucose concentration in the culture medium to be 1.3-1.7 g / L, the galactose concentration to be 0.6-1.0 g / L and the L-sodium lactate concentration to be 14-16 mM; the culture temperature is reduced, a fed-batch culture medium is fed every day, the glucose concentration in the culture medium is maintained at (2-2.8) g / L, the galactose concentration is maintained at (1.7-2.2) g / L, and cells are harvested. Galactose is introduced to serve as a second carbon source, and control over the culture initial metabolism environment and the carbon source in the culture stage is combined, so that the maximum accumulation amount of lactic acid is obviously reduced, the cell culture period is remarkably prolonged, and the maximum titer of the PD-1 antibody is remarkably improved compared with an existing process.

A method for measuring glucose and cortisol levels in earwax, wherein the measured cortisol and glucose levels are interpreted as average cortisol and glucose levels, and a medical device that provides effective, reliable, safe 5 and hygienic self-extraction of earwax.

The application provides a DNA enzyme triple helix molecular switch detection system suitable for a personal blood glucose meter, and a preparation method and application thereof, and belongs to the technical field of biosensors.The DNA enzyme triple helix molecular switch comprises an aptamer containing two nucleotide arm segments and DNA enzyme covalently coupled with a magnetic bead; the two nucleotide arm segments of the aptamer form a triple helix structure with the DNA enzyme; and the two nucleotide arm segments comprise a 5' end nucleotide sequence SEQ ID NO.1 of the aptamer and a 3' end nucleotide sequence SEQ ID NO.2 of the aptamer.The application uses a terminal fixation strategy to limit the flexibility of the original aptamer, stabilize the spatial conformation thereof, improve the affinity of the aptamer to the target, utilize the triple helix molecular switch containing the DNA enzyme and the nano-enzyme-gold nanoparticles, and realize accurate and sensitive detection of trace pollutants in food through determination of the reduction range of the glucose concentration in the detection liquid by using the household blood glucose meter.

The application provides a processing module, device and system for glucose concentration before and after exercise, the processing module is used for detecting glucose concentration of a subject and giving guidance information, the processing module is configured to determine a fluctuation type of a glucose concentration curve between before exercise and after exercise based on glucose data including time-varying glucose concentration between before exercise and after exercise of the subject, the fluctuation type reflects a change trend of the glucose concentration between before exercise and after exercise, and guidance information or suggestions related to exercise behavior are generated according to the fluctuation type. Therefore, the time spent on seeking doctor's advice can be reduced.

Methods and apparatus, including computer program products, are provided for processing analyte data. In some example implementations, a method may include generating glucose sensor data indicative of a host's glucose concentration using a glucose sensor; calculating a glycemic variability index (GVI) value based on the glucose sensor data; and providing output to a user responsive to the calculated glycemic variability index value. The GVI may be a ratio of a length of a line representative of the sensor data and an ideal length of the line. Related systems, methods, and articles of manufacture are also disclosed.

The utility model provides a glucose solution filling assembly for testing an electrochemical biosensor and a detection device, and relates to the technical field of biosensor detection, the glucose solution filling assembly comprises a liquid storage tank, a confluence piece, a constant-temperature water bath kettle and a sensor assembling assembly, the confluence piece is provided with a liquid inlet end and a liquid outlet end, the liquid inlet end is communicated with the accommodating cavities in a time-sharing manner and is higher than the liquid outlet end, the constant-temperature water bath pot receives a glucose solution discharged from the liquid outlet end, and the sensor assembling component fixes the electrochemical biosensor; in a non-filling state, the sensor assembling component and the confluence piece are close to and far away from the constant-temperature water bath kettle respectively, and in a filling state, the sensor assembling component and the confluence piece exchange position states respectively. By optimizing the pipeline connecting structure, the problems that an existing pipeline is complex in arrangement and large in occupied space are solved, and in the filling state and the non-filling state, the problem that glucose solution filling flexibility is poor is solved through movement matching of the confluence piece and the sensor assembling assembly.

A method for preparing an MOF-based glucose detection system, wherein a Zeolitic Imidazolate Framework (ZIF) is used as a metal-organic framework, and glucose oxidase (GOx) is loaded in the zeolitic imidazolate framework. The preparation method comprises the following steps: S1: adding water to a reaction flask in advance, and then sequentially adding a metal ion, an enzyme and an organic ligand in a molar ratio of 100-1500:1-10:1-150, and 0.1-0.5% (by weight) of ammonia water to the reaction flask, S2: mixing and reacting same at room temperature for more than 6 hours, and S3: after centrifugation by means of a centrifuge, removing the supernatant to obtain a solid precipitate of the Gox-MOF material loaded with glucose oxidase. A sensor for detecting trace glucose concentration in saliva, and an oral glucose meter comprising the sensor.

The present application relates to a kind of by chrysophyte fermentation-light coupling high-efficiency production of fucoxanthin method, comprising: chrysophyte is inoculated into fermenter and is carried out heterotrophic culture, while the algal liquid is continuously or intermittently lighted;Culture medium includes basic medium and feed medium, C / N is 4:1-40:1, nitrogen source uses organic nitrogen source or inorganic ammonium nitrogen;The glucose concentration in basic medium is 5-15g / L, temperature is 25-32℃, dissolved oxygen is controlled at 5-80%, pH is 4-8, light intensity 5-600 μmol m ‑2 s ‑1 ;Glucose concentration is monitored in time during the cultivation process, when glucose concentration is reduced to 0.5-3g / L, using peristaltic pump to flow feed medium is added to flow culture, control the glucose concentration in whole flow culture process in 1-10g / L;After 100h of cultivation, every 1-5h is sampled to detect the biomass dry weight contained in the culture medium in fermenter, when the detection value is unchanged or begins to drop, fermentation is finished, harvest, and the harvested product is used for extracting fucoxanthin.The present application establishes the feasibility basis of fermentation-light coupling chrysophyte cultivation to scale production of fucoxanthin.

1. Name of the product in this design: Blood Glucose Analyzer. 2. Purpose of this design: A medical device for measuring the concentration of glucose in human blood. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

The invention discloses a nanogold and wood composite material, a preparation method, application and a method for determining the content of glucose in reconstituted tobacco, glucose oxidation is directly catalyzed through the nanogold and wood composite material (AuNPs and wood), the glucose and tetramethyl benzidine (TMB) are subjected to a chromogenic reaction, and the content of the glucose in the reconstituted tobacco is determined by combining the linear relation between absorbance and the glucose concentration. And whether the glucose exists in the reconstituted tobacco and the concentrated solution sample or not and the specific content of the glucose can be accurately judged. The method provided by the invention can quickly obtain a detection result within 30 minutes, is suitable for efficiently screening reconstituted tobacco and concentrated solution samples with the glucose content lower than 0.01 gL <-1 >, can accurately determine the actual content of glucose in the reconstituted tobacco and the concentrated solution, does not need to depend on a standard substance or carry out modeling maintenance, and is simple and convenient to operate. The equipment cost is obviously reduced; and the operation process is simplified.

The invention relates to a system for regulating the concentration of glucose in the blood of a person, comprising: - a device for selectively supplying at least one and preferably two substances to said person, - at least one and preferably two infusion sets connectable to said device; - at least one sensor for measuring a glucose concentration in the blood of said person; - a controller for controlling said device such that a certain amount of a said substance is supplied per time unit, wherein said controller is arranged to determine a slope of the measured glucose concentration and if said slope exceeds a first threshold value said controller is arranged to control the device to supply a pre-injection amount of said at least one substance, said pre-injection amount being a percentage of a maximum pre-injection amount, wherein said percentage is dependent on the determined slope.

The invention provides a method for estimating an energy supply proportion based on glucose and ketone bodies and a related method and equipment, and the method for estimating the energy supply proportion comprises the steps: building a metabolic model based on a target metabolic pathway, the metabolic model being used for representing the relationship among a plurality of target metabolites related to the target metabolic pathway; a measured glucose concentration and a measured ketone body concentration are obtained, the measured glucose concentration and the measured ketone body concentration represent the glucose concentration and the ketone body concentration of blood in different tissues where the target metabolic pathway is distributed respectively, and the multiple target metabolites comprise glucose and ketone bodies of the blood; estimating a concentration of a first portion of the plurality of target metabolites based on the measured glucose concentration, the measured ketone body concentration, and a metabolic model; an energy supply ratio of glucose and fat is determined based on the concentration of the first portion of the plurality of target metabolites. Therefore, the convenience of estimating the energy supply proportion can be improved.

The present invention provides a biosensor for detecting glucose in saliva by using a saliva glucose measurement device, the biosensor comprising: an electrically insulated substrate; a plurality of electrodes disposed on the substrate and including a working electrode and a reference electrode for detecting glucose in the saliva; and a reagent layer disposed on the plurality of electrodes, wherein the reagent layer is disposed in a saliva inflow path which is located in the biosensor and configured to allow the saliva to flow thereinto. The reagent layer includes glucose dehydrogenase (GDH) and an electron transfer mediator, the saliva glucose measurement device is configured to apply a voltage to the working electrode and the reference electrode, the working electrode and the reference electrode are configured to transmit, to the saliva glucose measurement device, a current signal generated due to an oxidation / reduction reaction between the glucose dehydrogenase and the glucose in the saliva according to the applied voltage, and the value of the applied voltage is included in a numerical range of 150 mV to 300 mV.

This invention relates to an ATR sensor (10) for determining glucose concentration in a fluid, comprising a sensor housing (12) wherein the sensor housing (12) accommodates at least the following sensor components: an infrared radiation source (22); an ATR element (24) designed to transmit infrared radiation emitted by the infrared radiation source (22) by total internal reflection at at least one interface of the ATR element (24); at least one infrared detector (40) designed to sense the infrared radiation transmitted by the ATR element (24) and output a corresponding infrared measurement signal; and at least two infrared bandpass filters (36a, 36b) disposed between the ATR element (24) and the infrared detector (40), each infrared bandpass filter (36a, 36b) being designed such that only infrared radiation with a wavenumber within a predetermined wavenumber window (F1, F2) passes through. The first infrared bandpass filter (36a) allows a wavenumber range of 1005 cm⁻¹ at a temperature of 37°C. ‑1 Up to 1025 cm- 1 Infrared radiation at the first wavenumber window (F1) passes through. The second infrared bandpass filter (36b) allows infrared radiation with a range of 1075 cm⁻¹ at a temperature of 37°C. ‑1 Up to 1095 cm ‑1 Infrared radiation of the second wavenumber window (F2) passes through.

A technique for treating diabetes that recognizes patient insulin sensitivity is a time-varying physiological parameter. The described techniques for treating diabetes include measuring interstitial fluid glucose concentration, reading insulin delivery data, determining patient insulin sensitivity based on the interstitial fluid glucose concentration and insulin delivery data, and a time-varying physiological parameter, and dispensing an insulin dose from an insulin delivery device based on the determined patient insulin sensitivity.