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4609 results about "Biosensor" patented technology
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A biosensor is an analytical device, used for the detection of a chemical substance, that combines a biological component with a physicochemical detector. The sensitive biological element, e.g. tissue, microorganisms, organelles, cell receptors, enzymes, antibodies, nucleic acids, etc., is a biologically derived material or biomimetic component that interacts, binds, or recognizes with the analyte under study. The biologically sensitive elements can also be created by biological engineering. The transducer or the detector element, which transforms one signal into another one, works in a physicochemical way: optical, piezoelectric, electrochemical, electrochemiluminescence etc., resulting from the interaction of the analyte with the biological element, to easily measure and quantify. The biosensor reader device with the associated electronics or signal processors that are primarily responsible for the display of the results in a user-friendly way. This sometimes accounts for the most expensive part of the sensor device, however it is possible to generate a user friendly display that includes transducer and sensitive element (holographic sensor). The readers are usually custom-designed and manufactured to suit the different working principles of biosensors.
Silicone composition for biocompatible membrane
InactiveUS20050090607A1Microbiological testing/measurementSynthetic resin layered productsSensor materialsPolymer
Owner:DECOM
Medication & health, environmental, and security monitoring, alert, intervention, information and network system with associated and supporting apparatuses
InactiveUS20060154642A1Facilitate user and/or occupant well beingExtended stayDispersed particle filtrationDrug and medicationsNetworked systemHealth administration
Systems and apparatuses include devices, biosensors, environmental sensors, security related sensors, networked products, communications processors and components, alert and information components, processors, and software to support: 1) facilitating medication regimen and patient / user health administration, dosage control, tracking, compliance, information inquiry and presentation, reminder and notification; 2) providing monitoring, information, ordering, and intervention; 3) presenting the option of leveraging the preventative care, alert and notification components with other components to facilitate user or occupant well being, along with living, work area and dwelling environmental or security safety; and 4) enhancing the dwelling, living or work area with products that may be networked to support the widespread acceptance of these systems and apparatuses. The systems include a) processing, centralizing and communicating device commands and / or programs, e.g. a multifunctional device controller; b) device administration; c) patient / user information; d) dwelling environmental safety; e) security breach information; f) centralized and remote apparatus and system activations through primary component or at least one backup.
Owner:INSIGNIO TECH
Biosensor membranes composed of polymers containing heterocyclic nitrogens
InactiveUS6932894B2Easy CalibrationConsider sensitivityImmobilised enzymesBioreactor/fermenter combinationsAnalyteNitrogen
Owner:ABBOTT DIABETES CARE INC
Silicone composition for biocompatible membrane
InactiveUS20080045824A1Prevent penetrationMicrobiological testing/measurementSynthetic resin layered productsSensor materialsBiosensor
Owner:DEXCOM INC
Membrane suitable for use in an analyte sensor, analyte sensor, and associated method
ActiveUS20050173245A1Facilitate linear responsivenessEasy CalibrationImmobilised enzymesBioreactor/fermenter combinationsMetaboliteSuperoxide
A multifunctional membrane is provided. The multifunctional membrane is suitable for use in an analyte sensor. In a particular application, the multifunctional membrane may be used in connection with an amperometric biosensor, such as a transcutaneous amperometric biosensor. Some functions of the membrane are associated with properties of membrane itself, which is comprised of crosslinked polymers containing heterocyclic nitrogen groups. For example, the membrane, by virtue of its polymeric composition, may regulate the flux of an analyte to a sensor. Such regulation generally improves the kinetic performance of the sensor over a broad range of analyte concentration. Other functions of the membrane are associated with functional components, such as a superoxide-dismutating / catalase catalyst, either in the form of an enzyme or an enzyme mimic, that can be bound to the scaffold provided by the membrane. The effect of any such enzyme or enzyme mimic is to lower the concentration of a metabolite, such as superoxide and / or hydrogen peroxide, in the immediate vicinity of the sensing layer of the biosensor. Lowering the concentrations of such metabolites, which are generally deleterious to the function of the sensor, generally protects or enhances biosensor integrity and performance. The membrane is thus an important tool for use in connection with analyte sensors, amperometric sensors, biosensors, and particularly, transcutaneous biosensors. A membrane-covered sensor and a method for making same are also provided.
Owner:ABBOTT DIABETES CARE INC
Implantable biosensor system, apparatus and method
InactiveUS6965791B1Good biocompatibilityIncrease volumeImmobilised enzymesBioreactor/fermenter combinationsForeign matterInterstitial glucose
An implantable biosensor assembly and system includes an enzymatic sensor probe from which subcutaneous and interstitial glucose levels may be inferred. The assembly may be associated by direct percutaneous connection with electronics, such as for signal amplification, sensor polarization, and data download, manipulation, display, and storage. The biosensor comprises a miniature probe characterized by lateral flexibility and tensile strength and has large electrode surface area for increased sensitivity. Irritation of tissues surrounding the probe is minimized due to ease of flexibility and small cross section of the sensor. Foreign body reaction is diminished due to a microscopically rough porous probe surface.
Owner:SORENSON DEVMENT
Healthcare networks with biosensors
InactiveUS20050101841A9Privacy protectionElectrotherapyData processing applicationsData controlInternet privacy
A healthcare network is provided for sharing information concerning the health of a user with at least one outside source, the network including a biosensor associated with the user that generates a biosensor signal containing the information; and a personal data control means including receiving means for receiving the biosensor signal, input means for receiving a privacy input from the user, and output means for generating a response signal based on the biosensor signal and privacy input. The network also includes a data allocation and processing module including means for receiving the response signal, and means for generating and directing an output signal to the at least one outside source, wherein the module is responsive to the response signal, and wherein the availability of the information to the at least one outside source is responsive to the privacy input.
Owner:BINFORMA GROUP LIABILITY
Apparatus and methods for analyte measurement and immuno assay
ActiveUS20030170881A1Avoid disadvantagesBioreactor/fermenter combinationsBiological substance pretreatmentsPoint of careOrganism
The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand / ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
Owner:ABBOTT POINT CARE
Biosensors having improved sample application and uses thereof
InactiveUS7118667B2Improve distributionEnhance introductionImmobilised enzymesBioreactor/fermenter combinationsAnalyteEnzyme
The present invention relates to biosensors having improved sample application and measuring properties and their uses for detection, preferably, quantitative measurement, of analyte in a liquid sample. In particular, the invention provides for a biosensor having a sample application, reaction area and liquid soluble hydrophilic material facilitating the speed and uniformity of sample application, especially small volume sample application, via capillary flow. Methods for assaying analytes or enzymes using the biosensors are further provided.
Owner:LEE JIN PO
Biosensor membranes composed of polymers containing heterocyclic nitrogens
InactiveUS20050241957A1Easy CalibrationConsider sensitivityMicrobiological testing/measurementVolume/mass flow measurementAnalyteNitrogen
Owner:ABBOTT DIABETES CARE INC
Electrochemical cell
InactiveUS6413410B1Improve accuracyImprove reliabilityWeather/light/corrosion resistanceMicrobiological testing/measurementAnalyteElectrochemical biosensor
This invention relates to a biosensor and more particularly to an electrochemical biosensor for determining the concentration of an analyte in a carrier. The invention is particularly useful for determining the concentration of glucose in blood and is described herein with reference to that use but it should be understood that the invention is applicable to other analytic determinations.
Owner:LIFESCAN INC
Modification assisted profiling (MAP) methodology
Methods of utilizing a biosensor platform for the purpose of studying macromolecule interactions is provided. Also provided are methods of sorting monoclonal antibodies directed against a particular antigen into functional groups wherein each group exhibits a characteristic binding profile to the antigen.
Owner:REGENERON PHARM INC
Methods for improving performance and reliability of biosensors
InactiveUS6885883B2Microbiological testing/measurementDiagnostic recording/measuringCurve fittingMonitoring system
The present invention relates to a predictive-kinetic method for use with data processing of a sensor-generated signal, as well as, microprocessors and monitoring systems employing such a predictive-kinetic method. Data from a transient region of a signal is used with suitable models and curve-fitting methods to predict the signal that would be measured for the system at the completion of the reaction. The values resulting from data processing of sensor response using the methods of the present invention are less sensitive to measurement variables.
Owner:ANIMAS TECH +1
Biofouling self-compensating biosensor
InactiveUS20070299617A1Reduce the burden onPatient compliance is goodImmobilised enzymesBioreactor/fermenter combinationsEngineeringBiofouling
An in vivo biosensor disposed upon a subject comprising an electrochemical cell having a plurality of electrodes and a computer-controlled voltage source incorporating a potentiostat that is generative of a poise potential regime, which computer-controlled voltage source is operationally coupled to a computing device that: computes an output current whose magnitude is proportional to an amount of an analyte in a bodily fluid of the subject; and, adjusts the output current for drift due to biofouling at points in time greater than or equal to an induction period; and, outputs the amount of the analyte by transducing the adjusted output current. Methods and algorithms for adjusting the output current for drift due to biofouling are provided.
Owner:ULTRADIAN DIAGNOSTICS
Amperometric biosensors based on redox enzymes
InactiveUS6241863B1Improved kineticsReduced activityImmobilised enzymesBioreactor/fermenter combinationsLipid formationRedox enzymes
The invention includes various prototypical amperometric biosensors for the quantification of biological substrates such as fructose, creatinine, creatine, and sarcosine, and the methods for producing these biosensors. Also included in the invention is a minaturized version of the biosensing devices. The components of these prototypical biosensors are immobilized on a self-assembled monolayer (SAM) comprising chemisorbed alkanethiols. The deposition of an amphiphilic lipid layer to these systems increases the stability and activity of the resultant biosensor and enhances the rejection of many interferents. An additional feature of the invention is the co-deposition of the components of the sensor via a novel detergent dialysis protocol. The invention features two particular biosensor systems. One embodiment involves fructose dehydrogenase as the redox / sensor enzyme and fructose as the substrate / analyte. Another embodiment involves the measurement of the substrates / analytes, creatinine, creatine and sarcosine, using sacrosine dehydrogenase as the redox / sensor enzyme, with the involvement of creatinine amidohydrolase and / or creatine amidinohydrolase in the reaction pathway.
Owner:MONBOUQUETTE HAROLD G
Apparatus and methods for analyte measurement and immunoassay
ActiveUS7419821B2Bioreactor/fermenter combinationsBiological substance pretreatmentsPoint of careEngineering
Owner:ABBOTT POINT CARE
Physiological sample collection devices and methods of using the same
InactiveUS20030143113A2Good repeatabilityImmobilised enzymesBioreactor/fermenter combinationsTest stripsBiomedical engineering
Abstract of Disclosure Devices, systems and methods are provided for piercing the skin, accessing and collecting physiological sample therein, and measuring a characteristic, e.g., an analyte concentration, of the sampled physiological sample. The subject devices are in the form of a test strip which include a biosensor and at least one skin-piercing element which is a planar extension of a portion of the biosensor. At least one fluid pathway resides within a portion of the biosensor and within the skin-piercing element. The skin-piercing element has a space-defining configuration therein which acts as a sample fluid pooling area upon penetration into the skin. Systems are provided which include one or more test strip devices and a meter for making analyte concentration measurements. Methods for using the devices and systems are also provided.
Owner:LIFESCAN INC
Method of making a biosensor
InactiveUS7073246B2Immobilised enzymesBioreactor/fermenter combinationsConductive materialsEngineering
A method of making a biosensor is provided. The biosensor includes an electrically conductive material on a base and electrode patterns formed on the base, the patterns having different feature sizes. The conductive material is partially removed from the base using broad field laser ablation so that less than 90% of the conductive material remains on the base and that the electrode pattern has an edge extending between two points. A standard deviation of the edge from a line extending between two points is less than about 6 μm.
Owner:ROCHE DIABETES CARE INC +1
Washable wearable biosensor
ActiveUS20100268056A1Level of comfortAvoid overwritingDiagnostic recording/measuringSensorsAdhesiveMultiple sensor
A washable, wearable biosensor that can gather sensor data, communicate the sensed data by wireless protocols, and permits the analysis of sensed data in real-time as a person goes about their normal lifestyle activities. The biosensor can be worn in multiple positions, can be put on or removed quickly without having to apply or remove gels and adhesives, and provides a snug, comfortable fit to gather data with minimal motion artifacts. The textile, wearable device can support integrated photoplethysmography, skin conductance, motion, and temperature sensors in a small wearable package. The supported sensors may be coupled to utilization devices by channel-sharing wireless protocols to enable the transmission of data from multiple users and multiple sensors (e.g. both sides of body, wrists or hands and feet, or multiple people). An on-board processor, or the receiving utilization device, can map patterns of the physiological and motion data to signals or alerts such as a likely seizure, drug craving, or other states that the wearer may exhibit or experience. The sensor data may be sent by wireless transmission and received by a mobile phone or other personal digital device, a computer, a favorite toy, or another wearable device. The sensors may include multiple photoplethysmographs and / or one or more EDAs which perform a time-domain measurement of skin conductance
Owner:MASSACHUSETTS INST OF TECH
Electrochemical biosensor strip for analysis of liquid samples
InactiveUS6863800B2Easy to transportImmobilised enzymesBioreactor/fermenter combinationsElectrochemical biosensorConcentrations glucose
A biosensor in the form of a strip. In one embodiment, the biosensor strip comprises an electrode support, a first electrode, i.e., a working electrode, a second electrode, i.e., a counter electrode, and a third electrode, i.e., a reference electrode. Each of the electrodes is disposed on and supported by the electrode support. Each of the electrodes is spaced apart from the other two electrodes. The biosensor strip can include a covering layer, which defines an enclosed space over the electrodes. This enclosed space includes a zone where an analyte in the sample reacts with reagent(s) deposited at the working electrode. This zone is referred to as the reaction zone. The covering layer has an aperture for receiving a sample for introduction into the reaction zone. The biosensor strip can also include at least one layer of mesh interposed in the enclosed space between the covering layer and the electrodes in the reaction zone. This layer of mesh facilitates transporting of the sample to the electrodes in the reaction zone. In another embodiment, a biosensor strip can be constructed to provide a configuration that will allow the sample to be introduced to the reaction zone by action of capillary force. In this embodiment, the layer of mesh can be omitted. The invention also provides a method for determining the concentration of glucose in a sample of whole blood by using the biosensor of this invention.
Owner:ABBOTT LAB INC
Sliver type autonomous biosensors
InactiveUS20040180391A1Bioreactor/fermenter combinationsBiological substance pretreatmentsIn vivoElectrochemistry
In vivo or in vitro monitoring of chemical and biochemical species (e.g., pH, or glucose levels) in the interstitial fluid of patients or in a sample of a fluid to be analyzed is provided by a probe (10, 70, 210, 270). For in vivo monitoring, the probe is readily inserted by a minimally invasive method. Optical or electrochemical sensing methods are employed to detect a physical or chemical change, such as pH, color, electrical potential, electric current, or the like, which is indicative of the concentration of the species or chemical property to be detected. Visual observation by the patient may be sufficient to monitor certain biochemicals (e.g., glucose) with this approach. A CAP membrane allows high enzyme loadings, and thus enables use of microminiature probes, and / or diagnosis of low levels of the analyte(s), with sufficient signal-to-noise ratio and low background current.
Owner:CASE WESTERN RESERVE UNIV
Regeneration of biosensors
InactiveUS6812031B1Low rateReduce trafficMicrobiological testing/measurementMaterial analysis by electric/magnetic meansAnalyteEngineering
The invention comprises a method of regenerating a biosensor. It involves passing a background flow of fluid without reactive components through the flow passage. At a selected point in time a sample aliquot is injected into said background flow. At a point in time when a signal from said sensor is obtained the flow rate of the background fluid is increased. The invention also comprises a system for continuous monitoring of analytes in a biological fluid, the system having increased life by virtue of inherent regeneration of sensors employed. It comprises a biosensor (26, 30, 32), a sampling device (4) for providing a sample of said biological fluid, and means (10, 15, 18, 24) for passing a flow of a background fluid through said flow passage at selectable flow rates, means (20, 50, 55) for injecting said sample into said flow of background fluid, and means (50, 55) for increasing the flow rate of said combined flow. Means for achieving a washing action at the signal generating portion are provided.
Owner:SENZIME
Biosensor and method for producing the same
InactiveUSRE36991E1The way is simple and fastImprove accuracyImmobilised enzymesBioreactor/fermenter combinationsReaction layerEnzyme
A biosensor for rapid quantification of a specific component contained in various biological samples with high accuracy has an electrically insulating base, an electrode system including a working electrode and a counter electrode formed on one face of the insulating base, and a reaction layer formed on the insulating base in close contact with the electrode system. The reaction layer contains at least a hydrophilic polymer, a buffer and an enzyme which is separated from the buffer.
Owner:PANASONIC HEALTHCARE HLDG CO LTD
Method and instrument for detecting biomolecular interactions
InactiveUS20030059855A1Inexpensively incorporatedHigh-throughput screeningBioreactor/fermenter combinationsBiological substance pretreatmentsBeam splitterImaging spectrometer
Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An instrument system for detecting a biochemical interaction on a biosensor. The system includes an array of detection locations comprises a light source for generating collimated white light. A beam splitter directs the collimated white light towards a surface of a sensor corresponding to the detector locations. A detection system includes an imaging spectrometer receiving the reflected light and generating an image of the reflected light.
Owner:X BODY
Methods and apparatus for application of micro-mechanical forces to tissues
InactiveUS7494482B2Accelerate tissue ingrowthEnhancing tissue repairNon-adhesive dressingsBone implantMicron scaleCell-Extracellular Matrix
Methods and devices for transmitting micromechanical forces locally to induce surface convolutions into tissues on the millimeter to micron scale for promoting wound healing are presented. These convolutions induce a moderate stretching of individual cells, stimulating cellular proliferation and elaboration of natural growth factors without increasing the size of the wound. Micromechanical forces can be applied directly to tissue, through biomolecules or the extracellular matrix. This invention can be used with biosensors, biodegradable materials and drug delivery systems. This invention will also be useful in pre-conditioned tissue-engineering constructs in vitro. Application of this invention will shorten healing times for wounds and reduce the need for invasive surgery.
Owner:MASSACHUSETTS INST OF TECH +2
Biosensor
InactiveUS6740215B1Large responseImprove accuracyImmobilised enzymesBioreactor/fermenter combinationsHydrophilic polymersOxidoreductase
A biosensor comprising an electrically insulating base plate, an electrode system containing a working electrode and a counter electrode disposed on the base plate, and a reagent system comprising at least an oxidoreductase, a hydrophilic polymer and an electron mediator, wherein the reagent system further comprises a substance having a function to convert an organic product generated by direct reaction of a substrate to be measured with the oxidoreductase to another compound.
Owner:PANASONIC HEALTHCARE HLDG CO LTD
Small volume biosensor for continuous analyte monitoring
InactiveUS7045054B1Increase ratingsMinimize periodImmobilised enzymesBioreactor/fermenter combinationsRedox enzymesContinuous analysis
Sensors (10, 110, 210, 310, 410) and a method for detecting an analyte are described. Sensors (10, 110, 210, 310, 410) each have a volume of a hydrophilic medium (24) that retains an amount of analyte proportionate to the concentration of analyte in a biological fluid, electrodes (12) and a redox enzyme in contact with medium (24), and an electron transfer mediator. The fluid contacts sensors (10, 110, 210, 310, 410) and at initially predetermined intervals intermittently applies a potential to electrode (12) sufficient to oxidize the mediator and sensing current through electrode (12) as a function of the duration of the applied potential. The applied mediator oxidizing applied potential is maintained for a period of time sufficient to determine the rate of change of current with time through electrode (12). The current flow is correlated with the current flow for known concentrations of the analyte in medium (24).
Owner:ROCHE DIABETES CARE INC
Device having a flow channel
InactiveUS6939450B2High strengthImmobilised enzymesBioreactor/fermenter combinationsOptical measurementsEngineering
A device having a flow channel, wherein at least one flow-terminating interface is used to control the flow of liquid in the flow channel. The flow-terminating interface prevents the flow of the liquid beyond the interface. In one aspect, the invention provides a sensor, such as, for example, a biosensor, in the form of a strip, the sensor being suitable for electrochemical or optical measurement. The sensor comprises a base layer and a cover layer, and the base layer is separated from the cover layer by a spacer layer. The base layer, cover layer, and spacer layer define a flow channel into which a liquid sample is drawn therein and flows therethrough by means of capillary attraction. The flow of the sample is terminated by a flow-terminating interface positioned in the flow channel.
Owner:ABBOTT LAB INC
Membrane suitable for use in an analyte sensor, analyte sensor, and associated method
ActiveUS7699964B2Facilitate linear responsiveness and calibration and stabilityPreserve and improve performance of sensorImmobilised enzymesBioreactor/fermenter combinationsMetaboliteAmperometric biosensor
A multifunctional membrane is provided. The multifunctional membrane is suitable for use in an analyte sensor. In a particular application, the multifunctional membrane may be used in connection with an amperometric biosensor, such as a transcutaneous amperometric biosensor. Some functions of the membrane are associated with properties of membrane itself, which is comprised of crosslinked polymers containing heterocyclic nitrogen groups. For example, the membrane, by virtue of its polymeric composition, may regulate the flux of an analyte to a sensor. Such regulation generally improves the kinetic performance of the sensor over a broad range of analyte concentration. Other functions of the membrane are associated with functional components, such as a superoxide-dismutating / catalase catalyst, either in the form of an enzyme or an enzyme mimic, that can be bound to the scaffold provided by the membrane. The effect of any such enzyme or enzyme mimic is to lower the concentration of a metabolite, such as superoxide and / or hydrogen peroxide, in the immediate vicinity of the sensing layer of the biosensor. Lowering the concentrations of such metabolites, which are generally deleterious to the function of the sensor, generally protects or enhances biosensor integrity and performance. The membrane is thus an important tool for use in connection with analyte sensors, amperometric sensors, biosensors, and particularly, transcutaneous biosensors. A membrane-covered sensor and a method for making same are also provided.
Owner:ABBOTT DIABETES CARE INC
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