29 results about "Creatinine" patented technology

There is provided a method for diagnosing a subject with early onset muscle atrophy, said method comprising: obtaining a biosample from the subject; and assaying the biosample for one or more biomarkers, said one more biomarkers are taurine, proline, citrulline, trigonelline, thymidine, ornithine, glutamate, L-pyroglutamic acid, creatinine, adenine, nicotinamide, 2-methylhippuric acid, maltol, L-arginine, hypotaurine, L-glutamine, homogentisic acid, methylhistidine, oxoglutaric acid, xanthine, L-carnitine, succinate, or a combination thereof; and identifying the subject with early onset muscle atrophy on the basis of a deviation in the one or more of said one more biomarkers.

The invention discloses a protein / polysaccharide composite dialysis membrane based on in-situ loaded lanthanum carbonate and application of the protein / polysaccharide composite dialysis membrane, a lanthanum carbonate loaded protein / polysaccharide composite aggregate is used for modifying a porous filter membrane, and the dialysis membrane with a lanthanum carbonate loaded protein / polysaccharide self-assembled membrane as a compact skin layer and the porous filter membrane as a supporting layer is formed. By integrating a membrane separation mechanism of hemodialysis and an adsorption principle of blood perfusion, the skin layer of the dialysis membrane has molecular sieve separation and chemical adsorption functions, efficient removal of molecular uremic toxins (phosphorus, creatine liver, bilirubin, p-cresol sulfate and indol sulfate) with different sizes is synergistically realized, macromolecular proteins in blood are effectively intercepted by pore size screening, and the dialysis membrane has the advantages of simple structure, low cost and high efficiency. According to the present invention, by using the adsorption effect of the functional group on the surface of the membrane, the high removal rate on the protein-bound urotoxin is achieved, the high removal effect on phosphorus is particularly achieved, the blood compatibility is considered, the large-scale preparation is easily achieved, and the new idea is provided for the development of the high-performance blood purification material.

The application provides a method for improving the flavor and quality of tilapia surimi products, and belongs to the technical field of aquatic product processing, and comprises the following steps: tilapia muscles are cut into small pieces, an improving agent is added, and the muscles are ground; the well-stirred surimi is made into fish cakes and shaped; the fish cakes are taken out after floating, and are placed in cold water for cooling; the shaped fish cakes are respectively fried at 150 DEG C, 180 DEG C and 210 DEG C for 4 min; the fish cakes are vacuum packaged and stored in a refrigerator after cooling; the flavor of the surimi is analyzed, the quality of the surimi is detected, and the deterioration of the surimi is determined and analyzed; threonine, creatinine and glucose are dissolved in a phosphate buffer to obtain A liquid; diethylene glycol is taken, mixed with soybean oil, and mixed with an improving agent by vortexing to obtain B liquid; the A liquid and the B liquid are fully mixed in a 48 mL sealed high-temperature pressure-resistant reaction bottle, and then are placed in an oil bath for reaction and then are placed in an ice water bath for reaction termination; the solution after reaction is removed and is reserved; the MeIQx content, precursor substances and intermediate substances of the MeIQx generation simulation system solution after reaction simulation are determined.

A method for preparing glutaryl-bridged bis-biogenic guanidine chelate (GbG)MX2 including contacting biogenic guanidine (G) with glutaryl chloride in DMSO solvent for an acylation reaction, to yield glutaryl-bridged bis-biogenic guanidine GbG (G-b-G), and mixing the glutaryl-bridged bis-biogenic guanidine GbG as a chelating ligand and a non-toxic metal salt MX2 in an amphiphilic mixed solvent DMSO-H2O for a ligand addition reaction, to yield glutaryl-bridged bis-biogenic guanidine chelate (GbG)MX2. The biogenic guanidine (G) is selected from arginine (Arg), guanidine acetic acid (Gaa), creatine (Cra), and creatinine (Cran). M represents Fe2+, Mg2+, or Zn2+; and X represents CI−, AcO−(CH3COO−), LaO−(CH3CH(OH)COO−). The glutaryl-bridged bis-biogenic guanidine chelate (GbG)MX2 can be used as a catalyst for production of polybutylene succinate (PBS) using succinic anhydride (SAn) and BDO as monomers through a batch process or a continuous process. The catalyst of (GbG)MX2 of the disclosure is non-toxic, and the PBS synthesized features excellent environmental and biological safety.

The present disclosure relates to biocide compositions compatible with enzyme biosensors and methods of use thereof. More particularly, the present disclosure relates to biocide compositions compatible with enzymes used to measure creatine and creatinine levels.

The present invention relates to a method by which a server detects renal disease of a companion animal on the basis of protein, creatinine and specific gravity, and is a technique related to a method for detecting renal disease of a companion animal on the basis of protein, creatinine and specific gravity, the method comprising the steps of: (a) constructing an RGB ratio table, and photographing a urine test strip stained with urine, so as to generate a test image; (b) generating a first RGB value by extracting, from the test image, RGB values for each of a protein pad area and a creatinine pad area corresponding to a renal test item area from among the test item areas of the urine test strip; and (c) generating a first ratio value through the generated first RGB value and a specific gravity RGB value extracted from a specific gravity pad area in the test image, generating a second ratio value, which is the ratio between the specific gravity of the RGB ratio table, and protein and creatinine, correcting the RGB value of the protein pad area and the RGB value of the creatinine pad area by comparing the first ratio value and the second ratio value, and determining the renal health state of the companion animal by comparing the corrected RGB values.

The present invention provides a method of assessing the risk of an individual to suffer from epithelial cancer, an analyzer therefor, and a kit thereof, the method comprising: measuring the content of a metabolite in a sample of the individual, the metabolite comprising urea nitrogen, creatinine, or a combination thereof; and comparing the contents of the metabolites of the negative control group and the sample, when the content of the metabolites of the sample is lower than the content of the metabolites of the negative control group, the individual is assessed to have the risk of suffering from the urinary epithelial cancer, and the kit comprises at least one reagent for identifying the metabolites in the sample of the individual so as to accurately assess the risk.

The application discloses a kind of growing and fattening pig compound feed and its preparation method and application.The compound feed includes sesame stem leaf and basic daily ration, and the sesame stem leaf accounts for 2%~40% of the mass of compound feed.The application also discloses the preparation method of the compound feed, the application of sesame stem leaf in the preparation of the compound feed and the method for feeding growing and fattening pig.The compound feed of the application has no significant influence on the growth performance of growing and fattening pig after adding sesame stem leaf, has no safety hidden trouble to the growth process and edible part of pig, can improve pork color brightness, reduce back fat thickness, improve lean meat rate, improve pork tenderness, significantly reduce serum alanine aminotransferase, total bile acid and creatinine levels, improve liver and kidney function, and has no histopathology influence on main organs, with high safety.The application widens the feed application field of sesame as high-protein plant resources, and can be used to replace part of soybean meal, to alleviate the problem of high dependence on external feed raw materials.

The utility model provides a semipermeable membrane for hemodialysis and a hemodialysis device. Specifically, the semipermeable membrane sequentially comprises a first polyester fiber non-woven fabric supporting layer and a second polyester fiber non-woven fabric supporting layer, a first chitosan layer; a porous polysulfone membrane, wherein the average pore size of pores in the porous polysulfone membrane is in the range of 5 nm to 50 nm; a second chitosan layer; and a second polyester fiber non-woven fabric supporting layer. The semi-permeable membrane for hemodialysis has good biocompatibility, wider waste removal capacity (besides small molecular substances (such as urea and creatinine), middle molecular substances (such as beta2-microglobulin) can be effectively removed) and good durability.

The invention relates to the technical field of treatment of pollutants in wastewater, in particular to an anti-interference silver-vanadium metal-organic framework derivative material as well as a preparation method and application thereof. The preparation method comprises the steps that firstly, an AgV-MOF material with a two-dimensional twisted wave layered structure is prepared, then an Ag / V-MOF derivative material is prepared through alkaline etching, the Ag / V-MOF derivative material is provided with the wrinkled two-dimensional twisted wave layered structure, a large number of-OH groups are attached to the surface, and the Ag / V-MOF derivative material is prepared. Silver ions and vanadium ions can form an electron transfer path through bridging of organic ligands, so that electron transmission and transfer in the material are facilitated, and the adsorption performance of active sites of the material is further improved; therefore, the Ag / V-MOF derivative material can present the characteristics of high efficiency, short time and strong anti-interference performance when adsorbing creatinine under the combined action of the charge on the surface of the material, the conjugated structure of the ligand, electron transfer of the metal center and the two-dimensional twisted wave layered structure with the folds.

The present invention relates to methods for detecting and / or measuring alanine transaminase (ALT) activity, aspartate transaminase (AST) activity, alkaline phosphatase (ALP) activity, glucose levels, creatinine levels, urea levels, asymmetric dimethylarginine (ADMA) levels, and / or symmetrical dimethylarginine (SDMA) levels in a sample. The method allows all of the activities and analytes, or any combination of activities and analytes, to be measured in a single assay.

Creatinine levels may be monitored as a measure of kidney function. Conventionally, blood and / or urine tests are used for this purpose. Analyte sensors capable of monitoring creatinine in vivo may comprise: a sensor tail comprising at least a first working electrode, a creatinine-responsive active area disposed upon a surface of the first working electrode, a first membrane that is permeable to creatinine and overcoats the creatinine-responsive active area, and an oxygen scavenger located upon the sensor tail in proximity to the creatinine-responsive active area. The creatinine-responsive active area comprises a first electron transfer agent, a first polymer, and an enzyme system comprising multiple enzymes, particularly creatinine amidohydrolase, creatine amidohydrolase, and sarcosine oxidase, that are capable of acting in concert to facilitate detection of creatinine. An oxidase enzyme may serve as the oxygen scavenger, particularly glucose oxidase when detecting creatinine in fluids also containing glucose.

The invention discloses application of a semen nigellae extract in preparation of a product for preventing and / or treating androgenetic alopecia. The total content of nigella alkaloid and nigella alkaloid 4-O-sulfite in the nigella seed extract is not less than 2%. The preparation process comprises the following steps: degreasing nigellum nigrum medicinal material powder with petroleum ether, extracting with an acidic aqueous solution, and enriching with macroporous adsorption resin and specifically purifying with anion exchange resin in sequence. Experiments show that the extract can most significantly reduce the levels of testosterone (T), dihydrotestosterone (DHT) and creatinine (Cr) in an androgenetic alopecia model mouse body, increase the level of estradiol (E2) and effectively promote back hair regeneration, and the effect of the extract is significantly superior to that of a water extract, an alcohol extract and a positive control drug. The extract is clear in component and controllable in quality, can be used for preparing medicines or wash supplies with multi-target anti-hair loss and hair growth functions, and provides a novel efficient natural raw material for treating androgenetic alopecia.

This method for assisting the diagnosis of mental stress comprises: a step for measuring the concentrations of a plurality of components contained in a biological sample collected from a subject; classifying the detected persons based on the personality features; and generating stress diagnosis assistance information for diagnosing the degree of mental stress of the subject on the basis of the determined concentrations of the components including betaine, creatine, GABA, creatinine, serotonin, kynurenic acid, 3-hydroxybutyric acid, and citric acid and the classification of the personality characteristics. According to the method, information serving as a support for accurately diagnosing the presence or absence or degree of mental stress of a subject can be provided.

The present disclosure relates to a creatinine sensor comprising a first working electrode, a creatinine sensing layer on the first working electrode, and a hydrophilic polyurethane film covering the creatinine sensing layer, the creatinine sensing layer comprises a redox medium, creatinine acylamino hydrolase, creatinine amidino hydrolase and sarcosine oxidase. The creatinine sensor may further include a background sensing electrode that does not detect creatinine. The present disclosure further relates to a method for sensing creatinine, comprising: exposing a creatinine sensor having a background sensing electrode to a fluid; applying a potential to the first working electrode and the second working electrode; obtaining, from the first working electrode, a first signal proportional to the concentration of creatinine and background interference in the fluid; obtaining a second signal proportional to the concentration of background interference in the fluid from the second working electrode; and determining the concentration of creatinine in the fluid by subtracting the second signal from the first signal.

The invention provides a method of detecting a brain tumour in a subject, the method comprising the steps of: (i) measuring the amount of at least one metabolite in a sample of cerebrospinal fluid (CSF) taken from a subject, wherein the at least one metabolite is selected from the group consisting of: propionyl carnitine, butyryl carnitine, creatine, creatinine, valine, glutamine, leucine, betaine, isoleucine, asparagine, pyruvate, acetyl carnitine, carnitine, proline, valine and any combination thereof; and (ii) analysing the amount of the at least one metabolite in the sample of CSF, wherein when the amount of the at least one metabolite in the sample of CSF is above a threshold amount a brain tumour in the subject is detected. The invention further provides a method of detecting a brain tumour in a subject comprising identifying elevated or reduced amounts of metabolites in the CSF of a subject, compared to concentrations of the same metabolites in subjects known not to have a brain tumour.

The present invention provides a type of TB-thiophene-pyridinium photodynamic bactericidal photosensitizer and its preparation and application. 4-bromoaniline, paraformaldehyde, 5-aldehyde-2-thiopheneboronic acid and iodomethane are selected as raw materials and synthesized through multi-step reactions to obtain: #imgabs0# Three TB-thiophene-pyridinium derivatives have excellent photophysical properties, pH applicable range, viscosity response, AIE properties and good biocompatibility. DCHA probe detects that all three products can produce ROS, and under the same conditions, the ROS yield of 14 is higher. DHR123 probe and EPR detect that all three compounds can produce superoxide anions. The three products have low dark toxicity and phototoxicity to normal cells; they have low dark toxicity but high phototoxicity to A549 (human non-small cell lung cancer cells), and the IC of A549 cells after illumination is low. 50 The serum creatinine levels were significantly reduced from >100 to 0.31, 0.11, and 1.4 μg·mL, respectively. ‑1 , and has a high safety factor, making it an excellent PDT anti-tumor photosensitizer with great value for further research and development.

An exemplary embodiment of the present disclosure provides a biosensor that can facilitate detection of the molecules creatinine, creatine and / or sarcosine in a minimal-equipment, portable, and low-cost fashion. Some aspects of the disclosure relate to methods and systems to enable quantitative measurement of certain biomarkers at the point of care without expensive instrumentation.

Systems and methods for determining an alarm status for a health index using the health index and one or more pieces of chemical information are disclosed. The chemical information may include potassium levels, creatinine levels, etc. The determined alert status may be provided to a user or process.

The invention belongs to the technical field of biology, and particularly relates to application of bacteroides vulgaris in preparation of medicine for preventing and treating sepsis injury, the sepsis injury is kidney injury caused by sepsis, the survival time of mice with sepsis can be obviously prolonged after pretreatment of bacteroides vulgaris, the survival rate of the mice is increased, and the application of bacteroides vulgaris in preparation of medicine for preventing and treating sepsis injury is achieved. In addition, the traditional Chinese medicine composition can obviously improve mouse kidney tissue morphological lesions, inhibit CLP-induced mouse kidney tissue pathological morphological injuries, obviously reduce serum BUN and Creatinine contents and slow down mouse CLP-induced sepsis kidney injuries, and a new medicine is provided for preventing and treating sepsis injuries.

Systems, devices, and methods include approaches involving comparing an analyte level measured using a chemical sensor and based on an optical property to a threshold, determining that a creatinine level, a potassium level, or a sodium has reached the threshold, and generating a visual recommendation on a user interface to consume a source of protein, a source of potassium, or a source of sodium.

Disclosed is a personal care composition comprising a carboxymethyl cysteine compound and a creatinine compound wherein the creatinine compound is selected from the group consisting of creatinine, creatinine salts, creatinine solvates, creatinine hydrates, and combinations thereof, and the content of the carboxymethyl cysteine compound is at least 0.00001% and no more than 10% of the weight of the composition.

The invention discloses a composition with a permeation promoting effect as well as a preparation method and application thereof, and relates to the technical field of cosmetics. The composition disclosed by the invention is obtained by fermenting a fermentation substrate by thalli; the fermentation substrate is prepared from the following raw materials: a dogwood extract, creatinine and polyhydric alcohols. The composition provided by the invention has an excellent penetration promoting effect, can promote the absorption of active ingredients by skin, is free of irritation to skin temperature, is suitable for being used as a penetration promoting agent for preparing cosmetics, and improves the utilization rate of the active ingredients of the cosmetics.

The present invention relates to a use of a composition for preventing, alleviating, or treating diabetic kidney disease, the composition comprising zinc salt and cyclo-hispro as active ingredients. More specifically, the present invention provides: a composition for preventing, alleviating, or treating diabetic kidney disease, the composition comprising zinc salt and cyclo-hispro as active ingredients, wherein the composition, when administered alone or in combination with an antihypertensive agent and / or antidiabetic agent, exhibits the effect of preventing, alleviating, or treating diabetic kidney disease through the effect of reducing albuminuria, reducing the albuminuria / creatinine ratio, or increasing the glomerular filtration rate; and a method for preventing, alleviating, or treating diabetic kidney disease using same.

A sample testing device comprising at least one working electrode and a reagent dried on and / or adjacent to the surface of the working electrode. The reagent comprises a protein receptor comprising copper and / or a copper salt. The reagent further comprises an acidic buffering agent. There is also provided a sample testing device comprising at least a first working electrode and a second working electrode. A first reagent is provided on and / or adjacent to the surface of the first working electrode and a second reagent is provided on and / or adjacent to the surface of the second working electrode. The first reagent comprises a protein receptor. The second reagent comprises a creatinine receptor comprising an enzymatic receptor.

The invention belongs to the technical field of pharmaceutical preparations for treating cardiovascular system diseases, and relates to a telmisartan pharmaceutical composition and a preparation method thereof. The telmisartan pharmaceutical composition disclosed by the invention is prepared from telmisartan, phospholipid, cholesterol, creatinine and carboxymethyl chitosan and is prepared by adopting a film dispersion method. The liposome material is optimized, in the hydration process, a liposome film interacts with creatinine and carboxymethyl chitosan dissolved in a buffer solution, a more stable liposome structure is formed, the stability of the liposome is enhanced, and the drug loading capacity and the encapsulation efficiency of the liposome are improved.

The invention discloses a medicinal and edible composite plant solid beverage for assisting in reducing uric acid and a preparation method of the medicinal and edible composite plant solid beverage. According to the medicinal and edible composite plant solid beverage, in-vitro uric acid reducing activity and sensory scores of a fuzzy mathematical model are subjected to equal weight by adopting comprehensive scores, and a formula is optimized by adopting a response surface method. The obtained formula extract comprises 0.50 g of mint, 1.10 g of lotus leaf, 2.00 g of dandelion, 2.00 g of composite powder for adjusting taste and 3.00 g of composite powder for promoting uric acid excretion, and the xanthine oxidase inhibition rate is 84.02 + / -0.15%. An in-vitro anti-oxidation experiment proves that the solid beverage has an anti-oxidation effect. In-vivo experiments prove that the solid beverage has the effect of promoting uric acid excretion by obviously reducing blood uric acid, serum creatinine level and uric acid excretion coefficient of a model mouse; the activity of xanthine oxidase in vivo can be reduced, and the effect of inhibiting uric acid synthesis is achieved; meanwhile, the activity of glutathione peroxidase and superoxide dismutase is improved, and the antioxidant activity is achieved. The product is a medicinal and edible solid beverage and shows wide market potential.

The present invention discloses a metabolite combination and its application in predicting the results of immune reconstruction after antiretroviral treatment of HIV-infected persons. The present invention has discovered for the first time a metabolite combination and model that can accurately distinguish between immune responders and immune non-responders, which are Glycylhydroxyproline, gamma-Glutamylalanine, C16-Sphingosine-1-phosphate, dihydrouracil, deoxyeritadenine, creatinine, trans-S-(1-Propenyl)-L-cysteine, N6,N6,N6-Trimethyl-L-lysine, and glucosamine. By detecting the content of the metabolite combination in the subject, it is possible to distinguish whether the subject can restore optimal immunity after antiretroviral treatment, thereby better intervening in the treatment process of HIV-infected persons, and guiding the optimization of the treatment plan for HIV-infected persons according to the treatment response.

This invention discloses a method for constructing a MeIQx generation simulation system, comprising the following steps: S1 System construction: Diethylene glycol and water are added to a reaction tube, followed by a certain amount of glycine, creatinine, and glucose, which are then mixed to obtain the MeIQx generation simulation system. The mixture is thoroughly mixed. S2 Different system construction: Two portions of the MeIQx generation simulation system are prepared. One portion is supplemented with soybean oil to obtain an oil-containing MeIQx generation simulation system, while the other portion is not supplemented to obtain an oil-free MeIQx generation simulation system. S3 Inhibitor addition: A certain amount of inhibitor is added to each of the two systems, and the mixture is thoroughly mixed. S4 Reaction simulation: The reaction tubes of the two systems are heated at a certain temperature and then cooled. S5 Substance detection: The MeIQx content, precursor substances, and intermediate substances in the two MeIQx generation simulation system solutions after reaction simulation are detected. This invention, by constructing a chemical simulation system and adding exogenous inhibitors, provides a scientific basis for the precise reduction and control of MeIQx during high-temperature processing of aquatic products.