165 results about "Propenyl" patented technology

The invention discloses a thermal antistatic fabric based on polyamide fibers and a preparation method thereof, and relates to the technical field of textile fibers. When the thermal antistatic fabric based on the polyamide fiber is prepared, caprolactam, a flame retardant and hexamethylenediamine react to prepare pre-modified polyamide; the pre-modified chinlon and 3-chloro-1-propanethiol are subjected to a reaction, and modified chinlon is prepared; the preparation method comprises the following steps: sequentially reacting graphene oxide with mercaptopropyltrimethoxysilane and 2-(2H-benzotriazole-2-yl)-4-methyl-6-(2-propenyl) phenol, so as to obtain modified graphene oxide; the modified chinlon and the modified graphene oxide are mixed and then subjected to melt spinning, and modified chinlon fibers are obtained; and twisting the modified polyamide fiber, spinning, and post-processing to obtain the thermal antibacterial fabric based on the polyamide fiber. The warm-keeping antistatic fabric based on the polyamide fiber has good warm-keeping, antistatic, flame-retardant, anti-aging and mechanical properties.

The invention belongs to the technical field of preparation of thickening agents, and particularly relates to a preparation method of a polymer thickening agent for fracturing. The preparation method comprises the following steps: preparing a pretreated methacrylic acid (triethoxysilyl) methyl ester solution; preparing a pretreated 2-[[2-(methacryloyloxy) ethyl] dimethylammonium] acetate solution; preparing a water phase; and preparing the polymer thickening agent for fracturing. According to the preparation method of the polymer thickening agent for fracturing, acrylamide is used as a main monomer, maleic acid mono [2 (1-oxy-2-propenyl) oxyethyl] ester, methacrylic acid (triethoxysilyl) methyl ester and 2-[[2-(methacryloyloxy) ethyl] dimethylammonium] acetate are used as functional monomers, and the acrylamide, the maleic acid mono [2 (1-oxy-2-propenyl) oxyethyl] ester, the methacrylic acid (triethoxysilyl) methyl ester, the methacrylic acid (triethoxysilyl) methyl ester and the 2-[[2-(methacryloyloxy) ethyl] dimethylammonium] acetate are used as functional monomers. A redox initiator and an azo initiator are combined to serve as an initiator system, multi-monomer copolymerization is achieved through gradient temperature polymerization, and the temperature-resistant and salt-resistant polymer thickening agent for fracturing is prepared.

The invention discloses a preparation method of a warm-keeping and health-care composite fabric, and relates to the technical field of functional fabrics. The preparation method comprises the following steps: firstly, combining fumed silica with graphene oxide hydrogel to prepare mixed aerogel; the mixed aerogel is combined with allyl trichlorosilane, and is grafted to a macromolecular chain of polypropylene through maleic anhydride, so that the compatibility is improved, and the agglomeration problem is solved; secondly, calcining tourmaline, then directly carrying out quenching hydration modification, combining Si-OH groups on the surface with active groups in a polyester molecular chain, and spinning into hollow fibers; the mixed aerogel can absorb far infrared rays dissipated and emitted by the modified tourmaline, and the aerogel absorbing the far infrared rays can generate a resonance effect and a warm effect and permeate into the deep layer of the skin; the modified tourmaline has the capability of generating negative ions, and the gull rock powder is added for combined action, so that the antibacterial effect is achieved by destroying the structure of bacteria, and the health-care effect is achieved. The composite fabric prepared by the invention has warm-keeping and health-care effects.

According to the invention, rigid anthracene is introduced as a framework of bridged binuclear metal, a pyridylamino binuclear metal titanium-zirconium-hafnium catalyst is constructed, and the molecular weight of the obtained polymer can be effectively improved through the synergistic effect between the binuclear metal and the steric hindrance and electronic effect on the catalyst structure; the polyolefin elastomer (POE), the isotatic polypropylene (iPP) and the propenyl elastomer (PBE) are efficiently synthesized. The pyridylamino binuclear metal titanium-zirconium-hafnium catalyst has the advantages that synthesis is simple, raw materials are easy to obtain, and the product yield is high. In copolymerization of ethylene and alpha-olefin, the catalyst shows excellent activity (5.75 * 10 < 7 > g (POE). Mol <-1 > (M). H <-1 >) and alpha-olefin selectivity (the insertion rate reaches 16.2 mol%), and the polyolefin elastomer POE with excellent performance is prepared. In propylene polymerization, the regularity of the polypropylene chain segment can be effectively regulated and controlled by adjusting the steric hindrance and the electronic effect of the catalyst, and the regularity gt is prepared with high activity (3.84 * 10 < 7 > g (PP). Mol <-1 > (M). H <-1 >); and the polypropylene material with high stereoregularity is prepared from 80 mmmm% of polypropylene with high stereoregularity. In copolymerization of ethylene and propylene, an elastomer material which takes propylene as a main material, can regulate and control the ethylene content to be 5-50 wt% and has unique characteristics of a propylene-ethylene semi-crystalline copolymer is prepared. In addition, the pyridylamino binuclear metal titanium-zirconium-hafnium catalyst also shows excellent high-temperature resistance (higher than 160 DEG C), is suitable for high-temperature solution polymerization, and can be used for preparing high-performance polyolefin elastomers. Therefore, the invention has original innovation, and provides a new direction for the development of the field of polyolefin materials.

The invention discloses a basalt fiber reinforced asphalt mixture based on solid waste synergy and a preparation method of the basalt fiber reinforced asphalt mixture, and belongs to the field of asphalt mixtures. The basalt fiber reinforced asphalt mixture based on solid waste synergy is prepared from the following raw material components in parts by mass: 1000 to 1200 parts of aggregate, 3 to 5 parts of modified basalt fiber, 50 to 73 parts of waste rubber modified asphalt, 2 to 4.38 parts of amphiphilic epoxy resin, 0.7 to 1.5 parts of curing agent and 0.06 to 0.13 part of accelerant, the modified basalt fiber is obtained by modifying triethoxysilyl butyraldehyde, 3-mercaptopropyltrimethoxysilane and allyl-1, 3-sultone, and the modified basalt fiber is prepared by modifying the triethoxysilyl butyraldehyde, the 3-mercaptopropyltrimethoxysilane and the allyl-1, 3-sultone; the amphiphilic epoxy resin is obtained by reacting dodecyl succinic anhydride, polyethylene glycol monomethyl ether 2000 and epoxy resin; m-phenylenediamine and 2-amino-4-cyanopyridine are adopted as the curing agent; n-methylimidazole is adopted as the accelerant; the asphalt mixture prepared by the invention has good rut resistance, crack resistance and water stability.

The invention discloses a preparation method, an intermediate and application of menochromone. The preparation method comprises the following steps: reacting 4-bromopyrrole-2-carboxylic acid with propargylamine to generate 4-bromo-N-propynyl pyrrole-2-formamide; the preparation method comprises the following steps: reacting 4-bromo-N-propinyl pyrrole-2-formamide with pinacol borane to generate a mixture; reacting the mixture with 2-(t-butyloxycarboryl amino)-5-iodo-1H-imidazole to generate (E)-(5-(3-(4-bromo-1H-pyrrole-2-formamido) prop-1-ene-1-yl)-1H-imidazole-2-yl) tert-butyl carbamate, and reacting the (E)-(5-(3-(4-bromo-1H-pyrrole-2-formamido) prop-1-ene-1-yl)-1H-imidazole-2-yl) tert-butyl carbamate with the tert-butyl carbamate; and reacting the (E)-(5-(3-(4-bromo-1H-pyrrole-2-formamido) prop-1-ene-1-yl)-1H-imidazole-2-yl) tert-butyl carbamate with a dioxane hydrochloride solution, so as to generate the menochromone. The invention provides a preparation method of menosin, which is short in synthetic route, simple and convenient to operate, high in product yield and suitable for industrial production.

The invention discloses a perillaldehyde benzyl derivative, a synthesis method thereof and application of the perillaldehyde benzyl derivative in preparation of a drug for resisting brain neuron dysfunction. According to the technical scheme, the perillaldehyde benzyl derivative is characterized in that the perillaldehyde benzyl derivative is 2-phenyl-1-(4-isopropenylcyclohex-1-ene) ethanone, the structural formula of the perillaldehyde benzyl derivative is shown in the specification, and the invention further specifically discloses a synthesis method of the perillaldehyde benzyl derivative and application of the perillaldehyde benzyl derivative to preparation of drugs for resisting brain neuron dysfunction. The perillaldehyde benzyl derivative synthesized by the invention can be used as an NMDAR2B agonist to act on NMDAR2B in a targeting manner, meanwhile, a p-PI3K / p-AKT signal channel is activated, the expression levels of NOX2 and NOX4 are inhibited, and the effect of resisting neuronal dysfunction is achieved.

A secondary battery and an electronic apparatus. Specifically, the secondary battery comprises: a positive electrode, a negative electrode, and an electrolyte; the positive electrode comprises a positive electrode current collector and a positive electrode material provided on the positive electrode current collector; the positive electrode material comprises lithium cobalt oxide; the electrolyte comprises methylene methane disulfonate and propenyl-1,3-sultone; relative to 100 parts by mass of the electrolyte, the sum of methylene methane disulfonate and propenyl-1,3-sultone is 0.02 parts by mass to 3.5 parts by mass. The overcurrent and over-temperature safety of the secondary battery are improved.

The invention relates to the technical field of chemical synthesis, and particularly discloses a compound with a peculiar smell removing function as well as a preparation method and application thereof. The chemical name of the compound is 2-ethoxy-3-((E)-methoxy-3-oxopropyl-1-alkene-1-yl) phenyl cinnamate, the smell of the compound is extremely light, sulfur-containing and nitrogen-containing compounds causing stink can be captured through a Michael addition reaction, and efficient peculiar smell removal is achieved. The preparation method comprises the following steps: (1) taking cinnamic acid as an initial raw material, and reacting with diethylamino sulfur trifluoride to prepare cinnamic acid acyl fluoride; (2) carrying out an esterification reaction on the cinnamic acid acyl fluoride and 2-methoxy-3-hydroxybenzaldehyde in the presence of 4-dimethylaminopyridine, so as to obtain 2-methoxy-3-formyl phenyl cinnamate; and (3) carrying out Wittig reaction on the 2-methoxy-3-formyl phenyl cinnamate and a phosphorus ylide reagent, so as to obtain the target compound.

The invention relates to a viologen derivative electrolyte solution with an electrochromic characteristic and a preparation method and application thereof. The electrolyte solution comprises a viologen derivative and ascorbic acid, the viologen derivative is selected from 1-butyl-4, 4 '-dipyridyl or 1-butyl-1'-(2-propenyl)-4, 4 '-dipyridyl, and the viologen derivative is selected from 1-butyl-4, 4'-dipyridyl or 1-butyl-1 '-( The obtained electrolyte solution can be used for preparing an electrochromic device. Compared with the prior art, the obtained electrochromic device based on the viologen derivative electrolyte can realize color conversion from colorless or brown to purple black under relatively small voltage, and has relatively large light modulation amplitude and relatively high response speed.

The invention discloses an epoxy resin-based dual-curing color-changing film material and a preparation method thereof, and relates to the technical field of functional polymer materials, and the epoxy resin-based dual-curing color-changing film material is prepared from the following components in parts by weight: 35-50 parts of epoxy resin, 10-15 parts of polypropylene glycol diglycidyl ether, 3-5 parts of a cationic thermal curing agent, 1, 3-bis (oxiranyl methyl)-5-(2-allyl)-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4- The photochromic coating is prepared from the following components in parts by weight: 20-30 parts of 1, 3, 5-triazine-2, 4, 6 (1H, 3H, 5H)-triketone, 3-5 parts of 1, 4-diacryloyl-1, 2, 3, 4-tetrahydro-6, 7-dimethyl quinoxaline, 5-8 parts of modified photochromic dye, 2-4 parts of metal organic framework nanocrystal, 30-40 parts of solvent and 1-2 parts of initiator. The film material is good in flexibility and aging resistance, remarkable in photochromic effect and long in service life.

To provide a composition exhibiting excellent mechanical characteristics and high heat resistance when cured, and to provide a cured product thereof.SOLUTION: The present disclosure relates to a composition containing a maleimide-based resin, a propenyl-based resin, and a radical scavenger, a cured product of the composition, a printed wiring board using the composition, a semiconductor encapsulating material using the composition, and a build-up film using the composition.SELECTED DRAWING: None

To provide a novel inverse latex using a novel metal ion sequestering agent.SOLUTION: There is provided a self-invertible inverse latex having an aqueous phase, comprising: a) a cross-linked anionic polyelectrolyte consisting of: at least one first monomer unit derived from 2-methyl-2-[(1-oxo-2-propenyl)amino]1-propane sulfonic acid in the form of a free or partially or totally salified acid; and at least one second monomer unit derived from at least one monomer selected from the group consisting of (2-hydroxyethyl)acrylate, (2,3-dihydroxypropyl)acrylate, (2-hydroxyethyl)methacrylate and the like; and at least one monomer unit derived from a cross-linking polyethylenic monomer; b) at least one chelating compound selected from the group consisting of ethylenediamine disuccinic acid in the form of trisodium salt, tetrasodium salt of glutamic acid, N,N diacetic, or the sodium salt of imminosuccinic acid.SELECTED DRAWING: None

The invention relates to the technical field of joint adhesives, in particular to weather-resistant epoxy joint paste, a preparation method and application of the weather-resistant epoxy joint paste to an air conditioner window machine. The weather-resistant epoxy seaming paste comprises a component A and a component B. The preparation method of the weather-resistant epoxy seaming paste comprises the following steps: reacting cysteine with EDA to prepare modified cysteine; enabling the modified cysteine to react with an ultraviolet light absorber 2-(2H-benzotriazole-2-yl)-4-methyl-6-(2-propenyl) phenol, so as to prepare a modified ultraviolet light absorber; the preparation method comprises the following steps: reacting 3, 3 ', 4, 4', 4 '-triphenylmethane triisocyanate with amino-modified nano zinc oxide to obtain isocyanate esterified nano zinc oxide; the preparation method comprises the following steps: reacting diisocyanate, isocyanated nano-zinc oxide and polyether polyol to obtain a polyurethane prepolymer, and mixing the polyurethane prepolymer with liquid epoxy resin to obtain a component A; 3, 3 '-dichloro-4, 4'-diaminodiphenyl methane and a modified ultraviolet light absorber are dispersed into ethyl alcohol, and a component B is prepared;

A polymer having a constitutional unit represented by formula (1), a constitutional unit represented by formula (2), a constitutional unit represented by formula (3), and a constitutional unit represented by formula (4) as repeating units, The present invention provides an electrode binder characterized by having a weight-average molecular weight of 520,000 to 1,100,000 and a creep displacement of 8% to 14% as determined by a nanoindentation test in accordance with ISO14577-1. [Formula 1] TIFF0007780687000017.tif48115 [Case 2] TIFF0007780687000018.tif48115However, in equation (1) and equation (2), R 1 , R 2 each independently represents a hydrogen atom or a methyl group; M represents Na, K, or Li; n and m represent the number of repetitions, and n / m is greater than 0 and not greater than 0.25. [C3] TIFF0007780687000019.tif48115However, in equation (3), R 3 is a hydrogen atom, R 4 is a methylene group, an ethylene group, a propylene group, or a butylene group, l is the number of repetitions, and m / l is 0.8 or more and less than 4.0. [C4] TIFF0007780687000020.tif54102In equation (4), R 5 represents a hydrogen atom or a methyl group, L represents -O- or -NH-, R 6 is an alkylene group having 1 to 10 carbon atoms, -R 9 A group represented by -O-R10-, or -R 11 -NH-R 12 - represents a group represented by R 7 represents an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms, and R 8 represents an alkyl group having 1 to 6 carbon atoms, and R 9 represents an alkylene group having 1 to 5 carbon atoms which may be substituted with a hydroxy group, and R 10 , R 11 , R 12each independently represents an alkylene group having 2 to 5 carbon atoms, p represents the number of repetitions, and p / m is 0.001 or more and 0.1 or less.

A polypropylene based composition comprising: A) from 40 wt% to 85 wt% of a first heterophasic propylene ethylene copolymer (HECO1) B) from 15 wt% to 60 wt%; of a second heterophasic propylene ethylene copolymer (HECO2) having: i) fraction soluble in xylene at 25°C ranging from 20.0 wt% to 38.0 wt%; ii) the melt flow rate (230°C / 5 kg.. ISO 1133) ranging from 0.2 g / 10min to 4.0 g / 10min; iii) intrinsic viscosity, measured in tetralin, of the fraction soluble in xylene at 25°C ranging from 5.7 dl / g to 9.2 dl / g.

The invention discloses a flame-retardant thermoplastic elastomer and a preparation method thereof, and relates to the technical field of high polymer materials. When the flame-retardant thermoplastic elastomer is prepared, cyanuric chloride sequentially reacts with 4-(phenylamino) benzaldehyde and N-(2-aminoethyl) maleimide to prepare a functional cross-linking agent; the preparation method comprises the following steps: grafting a vinyl phosphorus-containing monomer and 2-(2H-benzotriazole-2-yl)-4-methyl-6-(2-propenyl) phenol onto lignin through a free radical graft polymerization method to prepare modified lignin; the preparation method comprises the following steps: polymerizing polycaprolactone glycol and isophorone diisocyanate, and carrying out chain extension by using a bis (hydroxyethyl) furan monomer, so as to prepare polyurethane; uniformly mixing polyurethane, the modified lignin, a functional cross-linking agent and N, N-dimethyl formyl, drying and curing to obtain the flame-retardant thermoplastic elastomer. The flame-retardant thermoplastic elastomer prepared by the invention has the advantages of flame retardance, ultraviolet aging resistance and self-healing.

The invention discloses a preparation method and application of isotactic polypropylene, and belongs to the technical field of propylene catalytic polymerization. The invention solves the problem that the selective catalytic synthesis of the existing medium-tacticity polypropylene is difficult. The invention provides a preparation method of isotactic polypropylene, the isotacticity of the obtained isotactic polypropylene is 10-80%, the molecular weight range is 1.0 * 10 < 3 >-2.0 * 10 < 6 > g / mol, the molecular weight distribution is 1.1-8.0, and the obtained isotactic polypropylene can be used as a propenyl elastomer.

The present application relates to a kind of electrolyte additives and its preparation method, belong to electrolyte technical field;The present application uses propenyl-1,3-sulfonic acid lactone as raw material, using the double bond of propenyl-1,3-sulfonic acid lactone and the amino group of 4-amino-2-(trifluoromethyl) thiophene occurs Michael addition reaction under the catalysis of 1,8-diazabicyclo (7-ene) Undecane, obtain the intermediate with tertiary amine structure, then through the quaternary ammonium salt reaction of tertiary amine structure of intermediate and bromo atom of ethyl bromoacetate, obtain additive, the additive of the present application and phosphate ester additive are compounded to obtain electrolyte additive, the present application is modified by propenyl-1,3-sulfonic acid lactone, introduce fluorinated alkyl, effectively reduce intermolecular force, weaken the dependence of electrolyte viscosity on temperature, improve the ionic conductivity of electrolyte under low temperature condition.

The invention discloses a packaging film of an aluminum-plastic film for hot box testing, the packaging film sequentially comprises a bonding layer, a core layer and a heat sealing layer, the bonding layer is prepared by mixing maleic anhydride modified polypropylene, co-polypropylene and a vinyl or allyl elastomer, the melting point of the maleic anhydride modified polypropylene is 140-160 DEG C, the melt index is 3-8 g / min, and the vicat softening point is 110-150 DEG C; the core layer is prepared by mixing co-polypropylene and a vinyl or propenyl elastomer; the heat sealing layer is prepared by mixing co-polypropylene, an ethylene or propylene-based elastomer, low-melting-point acid modified polyolefin and a slipping agent, and the melting point of the low-melting-point acid modified polyolefin is 70-95 DEG C. The low-melting-point acid modified polyolefin with the melting point of 70-95 DEG C is added into the heat sealing layer, so that the packaging tension of the packaging film at the temperature of 130 DEG C is reduced, and the packaging film meets the hot box test requirement of the lithium ion battery monomer at the temperature of 130 DEG C.

Provided is a grease base oil that has excellent compatibility with respect to a nonpolar polymer material and has excellent water resistance, heat resistance, and low temperature fluidity. This grease base oil contains a polyalkylene glycol-based compound represented by formula (1).　(1): R1O-(EO)m-(PO)n-R2 (In formula (1), R1 represents an alkyl group having 1-3 carbon atoms, R2 represents a methyl group or hydrogen, EO represents an oxyethylene group, PO represents an oxypropylene group, EO and PO are randomly added, m represents the average addition mole number of EO and is 1-8, n represents the average addition mole number of PO and is 5-30, and the mass ratio of EO and PO is EO:PO=10:90 to 20:80.)

The invention relates to compounds and pharmaceutically acceptable salts thereof, and to their medical use. Exemplary medical uses are the prevention and treatment of a bacterial infection, for example, a mycobacterial infection, such as a Mycobacterium tuberculosis infection, e.g., in a respiratory system and / or extrapulmonic. The invention further relates to a use of such compounds, pharmaceutically acceptable salts thereof or prodrugs of the compounds as chemotherapeutic agents. Also, the invention relates to a use of such compounds, pharmaceutically acceptable salts thereof or prodrugs of the compounds for inhibiting mycobacterial type VII secretion.The compounds have the following formulawhereinQ and X are, respectively, CH and C, CR2 and C, CH and N, CR2 and N, or N and C;R1 is hydrogen, halide or optionally substituted linear or branched alkoxy having 1 or 2 carbon atoms;R2 is independently selected from hydrogen, halide or optionally substituted linear or branched alkoxy having 1 or 2 carbon atoms, andR3 is optionally substituted linear or branched alkoxy having 1-6 carbon atoms, haloalkyl having 1-6 carbon atoms, n-propyl, 2-propenyl, 2-propynyl, or n-pentyl,or a pharmaceutically acceptable salt of the compound, for use in the prevention or treatment of a bacterial infection.

The application discloses a kind of effectively prevent and control Gang Mei branch blight of nuisance pesticide and prevention and control method and application, specifically including the following components: methyl jasmonate 100-150mg / L, table 24-rape sprout lactone 0.01-0.5mg / L, 6-benzyl adenine 20-50mg / L, triacontanol 0.5-1mg / L, chitosan 300-600mg / L, organic silicon 100-400mg / L, phenylalanine 5-50mg / L, mannitol 5-30mg / L, betaine 50-300mg / L, 2 hydrated calcium chloride 150mg / L, eugenol 250mg / L, isopropenyl-5-chlorobenzimidazolone 0.02-0.05mg / L, alkyl phenol formaldehyde resin polyvinyl ether 800-1000mg / L, ethanol 10000-30000mg / L.The application is compounded by plant growth regulator, inorganic matter, amino acid and other components, induces Gang Mei planting seedling, so that it systematically obtains resistance, enhances defense, inhibits Gang Mei branch blight, stabilizes cell membrane and improves the ability of anti-abiotic adversity, and also helps to improve the content of Gang Mei medicinal component secondary metabolite.The pesticide prepared by the application does not contain pesticide chemical component, is safe, non-polluting, simple in use method, and can effectively prevent and control Gang Mei branch blight, improve Gang Mei yield, quality and medicinal value.

The application discloses a reaction type thermoplastic resin with a large free volume, a preparation method and a bismaleimide resin composition, and belongs to the technical field of polymer material toughening. N 2 a nucleophilic polycondensation reaction to obtain a polyaryletherketone / sulfone copolymer containing a reaction type group, wherein the bisphenol compound is selected from one or more of phenolphthalein, thymolphthalein, bisphenol fluorene and isoindolinone-based bisphenol. The application introduces a bisphenol compound with a large side group into the molecular chain of the thermoplastic resin to construct a large free volume structure, and simultaneously utilizes TGSH to provide an active propenyl group, so that the resin can participate in the curing and cross-linking reaction of bismaleimide. The bismaleimide resin composition using the resin as a toughening agent has a significantly improved toughness after curing.

The invention discloses a syringate compound capable of preventing and treating barn pests as well as a preparation method and application of the syringate compound. The syringate compound has the following molecular structure expression, and according to the design, the light stability is enhanced by utilizing a rigid cyclic structure of chrysanthemic acid, and the CarE activity can be inhibited through a propenyl side chain of eugenol, so that self metabolism inactivation of pyrethrin is blocked; .

The application relates to the technical field of compound preparation, and discloses a synthesis method of fosfomycin intermediate levofosfoxacin salt, which comprises the following steps: taking propynol as raw material, performing esterification reaction, adding Pt / C, Cu (II) EDTA and hydrogen into the obtained reaction solution to prepare a cis-propenyl dichloro oxygen phosphorus solution, adjusting the pH of the reaction solution by using ammonia gas after hydrolysis, and performing salt reaction and epoxidation by using R- (+) -alpha-phenylethylamine to obtain the product after post-treatment. The propynol is not hydrolyzed after esterification, so that the impurity propadienyl phosphate is reduced; the later hydrogenation can obtain higher-purity cis-propenyl phosphate; the step of hydrolysis after esterification is reduced, a large amount of water does not need to be distilled and concentrated, and energy consumption is reduced; the reaction temperature and hydrogen pressure in the hydrogenation step are both low, and the reaction safety is high; R- (+) -alpha-phenylethylamine is used in the epoxidation stage, so that the splitting operation is not needed, and the process is simplified; the solvents can be recycled and reused, and the method is environment-friendly.

Aqueous gel, its use in cosmetics and process to reduce the sticky effect felt during its application. Aqueous gel comprising from 0.5% wt to 5.0% wt of a crosslinked anionic polyelectrolyte (PA) comprising from 5.0% mol to 95.0% mol of monomeric units from 2-methyl-2-((1-oxo-2-propenyl)amino)-1-propanesulfonic acid partially or totally salified as an alkali salt or ammonium salt, from 4.9% mol to 90.0% mol of monomeric units of N,N-dialkylacrylamide and from 0.1% mol to 5.0% mol of monomeric units from a monomer of formula CH2=C(CH3)-C(=O)-O-(CH2-CH2-O-)n-R5; from 0.5% mass to 9.5% mass, either of an alkanol of formula R1-OH, or of a mixture of alkanols of formula R1-OH; or of a composition (C) of alkyl polyglycosides represented by the formulas R1-O-(G)xH, in which G represents either the remainder of glucose or the remainder of xylose and x represents a decimal number between 1.05 and 2.05;either a mixture (M) of said alkanol of formula R1-OH or of said mixture of alkanols of formula R1-OH and of said composition (C); from 0.0% mass to 3.0% mass one or more cosmetic active ingredients and the quantity of water necessary to make up to 100% mass in which the mass ratio (RM) having as numerator the mass of the alkanol(s) of formula R1-OH, or the mass of said composition (C) or the mass of said mixture (M) and as denominator, the mass of said cross-linked anionic polyelectrolyte (PA), is greater than or equal to 1 and less than or equal to 10; cosmetic skin care process using said aqueous gel; use, either of said alkanol of formula R1-OH, or of a mixture of alkanols of formula R1-OH, or of said composition (C) or of said mixture (M), with a view to reducing or eliminating the sticky effect felt when applying to the skin an aqueous gel comprising said anionic polyelectrolyte (PA);process for reducing or eliminating the sticky feeling experienced when applying an aqueous gel comprising said anionic polyelectrolyte (PA) to the skin by modifying its composition before application to the skin, by adding either the alkanol(s) of formula R1-OH, or said composition (C), or said mixture (M).;

A preparation process of 2-[2-(2, 4-difluorophenyl)-2-propylene-1-yl]-1, 3-propylene glycol belongs to the field of medical intermediates, and comprises the following steps: step 1, adding 1-[1-(bromomethyl) vinyl]-2, 4-difluoro-benzene and diethyl malonate into N, N-dimethylformamide, and then adding potassium carbonate for reaction; 2, after the reaction in the step 1 is completed, filtering to remove potassium carbonate, and then carrying out acid pickling, toluene extraction, saturated saline solution washing, concentration and rectification to obtain an oily substance; and step 3, adding the oily substance obtained in the step 2 into methanol, mixing, then adding sodium borohydride for reaction, and after the reaction is completed, concentrating, crystallizing and filtering to obtain the 2-[2-(2, 4-difluorophenyl)-2-propylene-1-yl]-1, 3-propylene glycol. According to the method, the cost is effectively reduced, so that the reaction period can be shortened, meanwhile, the reaction yield can be increased, and industrial production is facilitated.

This invention discloses a method for detecting genotoxic impurities in fosfomycin calcium. The method involves preparing a test solution and a reference solution using hydrochloric acid as a solvent, and then detecting the test solution and reference solution using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS / MS) to obtain the content of genotoxic impurities in fosfomycin calcium. The genotoxic impurities are: 1,2-epoxypropyl diethyl phosphate, (2-propenyl)-diethyl phosphate, allyl diethyl phosphate, and propyl diethyl phosphate. This invention develops an analytical method capable of simultaneously detecting four diethyl phosphonate genotoxic impurities in fosfomycin calcium. This method exhibits good specificity, injection precision, linear range, limit of quantitation, limit of detection, accuracy, repeatability, intermediate precision, and robustness. It can be used for the detection and monitoring of diethyl phosphonate impurities in fosfomycin calcium raw materials, ensuring product quality and improving the safety of clinical medication.

Disclosed herein are methods of treating compliment mediated diseases using a crosslinked poly(allyamine) polymer comprising the residues of 2-propen-1-ylamine, or a salt thereof, 1,3-bis(allylamino)propane, or a salt thereof, and 1,2-dichloroethane.