46 results about "Propynyl" patented technology

A cleansing wet wipe in which a base paper sheet is impregnated with a chemical liquid. The chemical liquid contains at least iodopropynyl butylcarbamate, polyamino-propyl biguanide, benzalkonium chloride, and cetylpyridinium chloride; and the content value for the iodopropynyl butylcarbamate in the chemical liquid is 0.005-0.02 mass % inclusive. The chemical liquid is adjusted to be acidic.

The invention discloses a preparation method, an intermediate and application of menochromone. The preparation method comprises the following steps: reacting 4-bromopyrrole-2-carboxylic acid with propargylamine to generate 4-bromo-N-propynyl pyrrole-2-formamide; the preparation method comprises the following steps: reacting 4-bromo-N-propinyl pyrrole-2-formamide with pinacol borane to generate a mixture; reacting the mixture with 2-(t-butyloxycarboryl amino)-5-iodo-1H-imidazole to generate (E)-(5-(3-(4-bromo-1H-pyrrole-2-formamido) prop-1-ene-1-yl)-1H-imidazole-2-yl) tert-butyl carbamate, and reacting the (E)-(5-(3-(4-bromo-1H-pyrrole-2-formamido) prop-1-ene-1-yl)-1H-imidazole-2-yl) tert-butyl carbamate with the tert-butyl carbamate; and reacting the (E)-(5-(3-(4-bromo-1H-pyrrole-2-formamido) prop-1-ene-1-yl)-1H-imidazole-2-yl) tert-butyl carbamate with a dioxane hydrochloride solution, so as to generate the menochromone. The invention provides a preparation method of menosin, which is short in synthetic route, simple and convenient to operate, high in product yield and suitable for industrial production.

The invention discloses an icaritin derivative, a composition and application, the structural formula of the icaritin derivative is as follows: in the structural formula, R1 is independently selected from hydrogen, hydroxyl and C1-C3 alkoxy; r2 is independently selected from hydrogen, an isopentenyl group, an isoamyl group and a Mannich base; r3 is independently selected from hydrogen, hydroxyl or OR3 ', R3 'is selected from rhamnosyl, rhamnose-(2-> 1)-glucosyl, rhamnose-(3-> 1)-glucosyl, propynyl and triazole groups substituted by alcoholic hydroxyl, benzyl and glycosyl; r4 is independently selected from a hydroxyl group or OR4 ', and R4' is selected from a propynyl group, a glucosyl group, and an alcoholic hydroxyl group, a benzyl group and a glycosyl substituted triazole group; r5 is independently selected from hydrogen, isopentenyl and Mannich base; mannich base is selected from N (CH3) 2 and N (CH2CH3) 2, R6 is independently selected from hydroxyl and OR6 ', and R6' is selected from hydrogen, rhamnosyl, rhamnose-(2-> 1)-xylosyl and rhamnose-(2-> 1)-rhamnosyl.The icaritin derivative provides a new direction for treatment of sarcopenia.

The present invention relates to a composition containing (a) a guanidine and / or an unsubstituted guanidine salt, and (b) at least one further component selected from the group consisting of 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one, 1, 2-benzisothiazolin-3-one, N-butyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, the cleaning agent is prepared from 2-benzisothiazolin-3-one, octyl isothiazolinone, bronopol, dibromo-nitrilopropionamide, dibromo-dicyanobutane, butyl carbamic acid iodopropynyl ester, aminomethyl propanol, aminoethyl propylene glycol, monoethanolamine, ethylhexylglycerin, hexylglycerin, 1, 2-pentanediol, 1, 2-hexanediol, 1, 2-heptanediol, 1, 2-octylene glycol, phenoxy ethanol and phenethyl alcohol. The cleaning agent is prepared from phenyl propanol, benzyl alcohol, isopropanol, ethylenediamine tetraacetic acid, (1-hydroxyethylidene) diphosphonic acid, 2-mercaptopyridine sodium oxide, 2-mercaptopyridine zinc oxide, o-phenylphenol, sorbic acid, benzoic acid, salicylic acid, lactic acid, citric acid and zinc. The invention also relates to an industrial product containing components (a) and (b), and to the use of said composition for the preservation of containers and for the preservation of industrial products. The invention also relates to the use of (a) a guanidine and / or an unsubstituted guanidine salt for improving the antimicrobial efficacy of one or more compounds selected from the group (b) described above.

Described herein are fabric softening compositions comprising a quaternary ammonium compound (e.g., an esterquat); a cationic polyquaternium polymer (e g., polyquaternium-7); a preservative system which comprises an organic acid (e.g., lactic acid or phosphonic acid); and 3-iodo-2-propynyl butylcarbamate (IPBC) or Dodecylguanidine Hydrochloride (DGH); and a phosphonic chelating agent (e.g., etidronic acid). Methods of making and using the fabric softening compositions are also described herein.

The invention relates to blends from iodopropargyl compound-containing and nitrogen-containing polymers with at least two beta aminoamine functions, to the preparation of these blends and to the use of these blends for the protection of technical materials from destruction by microorganisms, and to the technical materials finished with these blends

The invention relates to compounds and pharmaceutically acceptable salts thereof, and to their medical use. Exemplary medical uses are the prevention and treatment of a bacterial infection, for example, a mycobacterial infection, such as a Mycobacterium tuberculosis infection, e.g., in a respiratory system and / or extrapulmonic. The invention further relates to a use of such compounds, pharmaceutically acceptable salts thereof or prodrugs of the compounds as chemotherapeutic agents. Also, the invention relates to a use of such compounds, pharmaceutically acceptable salts thereof or prodrugs of the compounds for inhibiting mycobacterial type VII secretion.The compounds have the following formulawhereinQ and X are, respectively, CH and C, CR2 and C, CH and N, CR2 and N, or N and C;R1 is hydrogen, halide or optionally substituted linear or branched alkoxy having 1 or 2 carbon atoms;R2 is independently selected from hydrogen, halide or optionally substituted linear or branched alkoxy having 1 or 2 carbon atoms, andR3 is optionally substituted linear or branched alkoxy having 1-6 carbon atoms, haloalkyl having 1-6 carbon atoms, n-propyl, 2-propenyl, 2-propynyl, or n-pentyl,or a pharmaceutically acceptable salt of the compound, for use in the prevention or treatment of a bacterial infection.

The application discloses a polyarylbutene and a preparation method and application thereof. The polyarylbutene is obtained by polymerizing a multi-propargyl compound and a methylene compound in an organic solvent under the protection of inert gas. The method has mild conditions, the polymerized monomers are simple and easy to obtain, the polymer has high yield, high molecular weight, high atomic economy, and excellent regioselectivity and stereoselectivity. The polyarylbutene has excellent processability and high thermal stability, high refractive index, metal ion fluorescence quenching, and cell imaging, and can be applied to the fields of optics, detection, biology, medicine and environment.

Battery, including: an electrolyte comprising a first additive and a second additive, wherein the first additive has a structure represented by formula 1 and wherein the second additive comprises at least one of tripropargyl phosphate, propyl bis(2-propynyl) phosphate or ethyl bis(2-propynyl) phosphate; and a negative electrode plate comprising a negative electrode active material, wherein the negative electrode active material comprises the element silicon,

The present disclosure relates to the field of chemistry and medicine, and more particularly to a process for the preparation of 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl) ethyl]-5-methyl-N-propyl-2-alkynyl-1, 3-thiazol-2-amine (Compound 1), pharmaceutically acceptable salts and crystalline forms thereof, as well as methods for the preparation of 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl) ethyl]-5-methyl-N-propyl-2-alkynyl-1, 3-thiazol-2-amine (Compound 1). Methods for the treatment of congenital adrenal hyperplasia (CAH).

Examples of a biocide composition include an activated halogen compound selected from the group consisting of 2,2-dibromo-3-nitrlopropionamide; 2-bromo-2-nitropropane-1,3-diol; and 1,2-dibromo-2,4-dicyanobutane; benzisothiazolin-3-one; a pyridine-N-oxide selected from the group consisting of zinc pyrithione and sodium pyrithione; and a carbamate derivative selected from the group consisting of 3-iodo-2-propynyl butyl carbamate; zinc bis(dimethyldithiocarbamate); and bis(dimethyl carbamoyl) disulfide.

Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders that result in enzyme deficiencies that alter the production of adrenal steroids, due to 21-hydroxylase deficiency (a condition in which little or no cortisol biosynthesis occurs). A method is provided for administering 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-propa-2-inyl-1,3-thiazole-2-amine, or a pharmaceutically acceptable salt thereof, to adult subjects with congenital adrenal hyperplasia.

Three kinds of functionalized three-dimensional covalent organic framework materials, preparation method and application thereof in gas adsorption and separation belong to the technical field of porous organic framework material preparation.The three kinds of functionalized three-dimensional covalent organic framework materials TAM-DETP, TAM-DMTA and TAM-BPTA with ethoxyl, methyl and prop-2-yn-1-yloxy in the skeleton are prepared by Schiff base reaction with 2,5-diethoxyl terephthaldehyde, 2,5-dimethyl terephthaldehyde, 2,5-bis(prop-2-yn-1-yloxy) terephthaldehyde and tetra(4-aminophenyl) methane as raw materials under the catalysis of acetic acid, which are long-range ordered crystalline porous materials.The separation ratio of carbon dioxide / methane of TAM-BPTA is 23 at 273K and 100kPa; the separation ratio of carbon dioxide / methane of TAM-BPTA is 44 at 298K and 100kPa.

The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.

This invention discloses a method for preparing monohydroxymethylcyclopropane nucleoside analogs. The method includes: sequentially adding a vinyl nucleobase derivative and a propynyl thioacetal compound to a mixture of a gold-nitrogen heterocyclic carbene catalyst and a silver salt under inert gas protection. After reaction, a highly stereospecific and selective disulfide vinylcyclopropane nucleoside analog is obtained. Following hydrodesulfurization, a vinylcyclopropane nucleoside analog is obtained. Further oxidation, reduction, or deprotection in three steps yields the monohydroxymethylcyclopropane nucleoside analog. This invention provides a concise new route for the synthesis of vinylcyclopropane nucleoside and monohydroxymethylcyclopropane nucleoside analogs, with mild reaction conditions, overcoming the potential explosiveness and lengthy synthetic routes of traditional methods. The raw materials are readily available, and the product can be converted into various other useful potential bioactive molecules, demonstrating strong practicality.

This application provides a method for preparing methylcarboxylic acid-2-propynyl ester, comprising the following steps: (1) mixing dimethyl carbonate and propargyl alcohol, adding a first alkaline catalyst, stirring and heating to a temperature of 90-105°C, and distilling out methanol by reactive distillation to obtain a first component; (2) performing solid-liquid separation on the first component to obtain a first liquid, and performing vacuum distillation on the first liquid to remove propargyl alcohol and dimethyl carbonate to obtain methylcarboxylic acid-2-propynyl ester and residue; (3) performing vacuum distillation on the residue, replenishing dimethyl carbonate and the second alkaline catalyst with the distillate for reaction, and reusing the reaction liquid in step (2). This application uses the transesterification reaction of propargyl alcohol and dimethyl carbonate to synthesize methylcarboxylic acid-2-propynyl ester, which has high safety, low overall reaction temperature, fewer by-products and waste, and high yield.

The invention discloses a preparation method of an oxadiargyl sustained-release microcapsule suspending agent, which is characterized in that monodispersed silicon dioxide nanoparticles are used as a carrier, and a capsule wall is formed through the synergistic effect of chitosan and sodium alginate, so that directional adsorption and controllable release of oxadiargyl are realized. According to the oxadiargyl sustained-release microcapsule suspending agent disclosed by the invention, the action time of a drug on a target is prolonged through controlled release of the drug, the suspending agent is continuously effective in the growth cycle of crops, the number of times of applying the drug to the crops is reduced, the damage to the crops is reduced, the pollution to the environment is reduced, and the labor is saved. Meanwhile, due to the protection effect of the microcapsules, the storage stability of the preparation is improved.

The present disclosure relates generally to the treatment of adrenal dysfunction (such as congenital adrenal hyperplasia) with a combination of 2‑thiazolamine, 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-2-propyn-1-yl (crinecerfont) and certain pharmaceutical compositions of hydrocortisone (such as a delayed release oral pharmaceutical composition of hydrocortisone).

The application relates to the technical field of lithium ion batteries, in particular to an electrolyte and a battery. The electrolyte comprises an additive, a lithium salt, an organic solvent and an ionic liquid, wherein the additive comprises at least one of compounds with the structures shown in the following formula; in the formula, R1 is selected from any one of a methyl group, a propyl group, an ethyl group, an allyl group, a vinyl group, a propenyl group, an allyl group, an isopropenyl group, an ethynyl group, a propargyl group, a propynyl group, a 2-propenyl group, a 2-propynyl group, an isopropyl group, an ethynyl group and a tert-butyl group. The electrolyte of the application avoids capacity loss caused by three-step phase transition conversion of a traditional liquid electrolyte, can effectively prevent dissolution of polysulfides, and improves the fire-retardant effect, ionic conductivity and thermal chemical stability of the electrolyte.

The utility model discloses a gas purification device for preparation based on propynyl, which comprises a purification box, a purification structure, a feeding pipe, a feeding valve, an exhaust pipe, an exhaust valve and a spraying box, and relates to the technical field of gas purification, the gas purification device integrates multiple innovative designs and shows obvious advantages; firstly, according to the unique purification structure, through the principle of a stirring driver and a magnetic transmission, automatic rotation of a rotating circular ring, an inserting and sleeving shaft pipe and a cobweb exhaust pipe is achieved, and through the design, the contact area of gas and a purification assembly is increased, and the purification efficiency is greatly improved; meanwhile, due to the ingenious installation of the trumpet-shaped gathering piece, the gas can be gathered and guided to the purification assembly, the one-way Tesla valve effect is further formed, one-way drainage of the gas is ensured, and the purification effect is further improved.

The present disclosure relates to the adipate and malonate salts of 5-((1 R,4R)-2-oxa-5-azabicyclo [2.2.1]heptan-5-yl)-N-(3-( difluoromethyl)-1-((1r,4R)-4-((4-((3-(1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1 Hbenzo[d]imidazol-4-yl)prop-2-yn-1 -yl)oxy) piperidin-1-yl)methyl)cyclohexyl)-1 H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamid, to their crystalline forms, to their preparation and to their therapeutic use.

The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.

The present application belongs to the technical field of chemical herbicides, and particularly relates to a compound herbicide containing S-Isopropyl Methylcarbamate. The present application provides a compound herbicide containing S-Isopropyl Methylcarbamate, which is composed of S-Isopropyl Methylcarbamate-propynyl oxadiazolone microcapsule suspensible granules and propynyl oxadiazolone suspensible granules, so that: 1, part of the propynyl oxadiazolone is effectively microencapsulated, prolonging the effective period of weed control; 2, the compound herbicide has relatively high intensity of broadleaf weeds, gramineous weeds, and sedge weeds control effect in the early stage of the 100-day effective period, and can appropriately control various annual and perennial weeds throughout the effective period, ensuring outstanding weed control effect in corn, sorghum, peanut and other dry land crops.

The present invention relates to a non-aqueous electrolyte comprising a lithium salt, an organic solvent, and an additive, wherein the additive comprises a compound represented by the following chemical formula 1. [Chemical formula 1] JPEG2026511709000066.jpg60170 In the above chemical formula 1, R1 is an allyl group or a propagyl group, R2, R3, R4, and R5 are independently selected from hydrogen and C1-C5 alkyl groups, L is selected from a single bond and an alkylene group having C1-C10, and X is selected from -C(=O)-, -S(=O)-, and -S(=O)2-.

The application discloses a kind of herbicidal composition and its application, the composition includes active ingredient A and active ingredient B, wherein active ingredient A is formula (I) compound, active ingredient B is selected from one or more of oxadiazon, propynyl oxadiazon, cyclopentane oxadiazon.The mass ratio of active ingredient A and active ingredient B of the composition is 1:60-20:1.The component of the application is reasonable, and the effect of weeding in rice field is good, and its activity and weeding effect are not the simple superposition of each component, compared with the existing single preparation, with the characteristics of weeding effect, low drug dosage, broad herbicidal spectrum, good crop safety.

Ectoplasmic parasite infections in fish farming can cause significant difficulties and problems for the aquaculture industry. This disclosure generally relates to the treatment or control of ectopic parasite infections (such as sea lice) in fish (such as salmonids) using specific dosage regimens of isoxazoline. Specifically, the dosage regimen comprises the active ingredient shown in structural formula (I): (S)-3-methyl-N-(2-oxo-2-(prop-2-yn-1-ylamino)ethyl)-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)thiophene-2-carboxamide, including its salt, or N-oxide or solvate, at a dose of about 0.025 mg / kg / day to about 0.250 mg / kg / day, preferably about 0.025 mg / kg / day to about 0.125 mg / kg / day. Specifically, the dosage administration regimen includes oral administration for approximately 3 to approximately 10 consecutive days, preferably over a period of 7 consecutive days.

The invention discloses a multi-effect imidazoline corrosion inhibitor for acidizing and fracturing as well as a preparation method and application thereof, and relates to the technical field of oilfield chemistry, the preparation method comprises the following steps: uniformly stirring polyethylene glycol monomethyl ether and cyanuric chloride to react to prepare a polyether cyanuric chloride solution; the preparation method comprises the following steps: stirring 5-sulfosalicylic acid, propargyl alcohol, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and 4-dimethylaminopyridine to react to prepare a 5-sulfosalicylic acid propargyl alcohol ester product, reacting the 5-sulfosalicylic acid propargyl alcohol ester product with polyether cyanuric chloride to prepare a polyether-sulfonate disubstituted cyanuric chloride intermediate, and reacting the polyether-sulfonate disubstituted cyanuric chloride intermediate with polyether cyanuric chloride to prepare the polyether-sulfonate disubstituted cyanuric chloride intermediate. Dodecenylsuccinic acid and diethylenetriamine react to prepare an imidazoline intermediate, and the polyether-sulfonate disubstituted cyanuric chloride intermediate and the imidazoline intermediate are heated to react to obtain the polyether-sulfonate disubstituted cyanuric chloride. According to the prepared multi-effect imidazoline corrosion inhibitor, four functional groups are combined through chemical bonds, the defects of physical compounding are avoided, and the corrosion inhibition efficiency far exceeding that of physical compounding is achieved.

In general, the present disclosure is directed to a wood preservative composition. The wood preservative composition may be useful in inhibiting proliferation of wood decaying microorganisms. The wood preservative composition may include encapsulated 3-iodo-2-propynylbutylcarbamate (IPBC). The wood preservative compound may further include a succinate dehydrogenase inhibitor comprising penflufen. For instance, encapsulated IPBC and penflufen may be present in the wood preservative composition at a ratio of from about 1000:1 to about 1:50.

The application belongs to the technical field of pharmaceutical chemistry and pharmacology, and particularly relates to a flavanone schmidt rearrangement derivative, a preparation method and application thereof. A structural formula of the flavanone schmidt rearrangement derivative is shown in the following formula: wherein R represents one of benzyl, propynyl, allyl, isopentenyl, methyl, ethyl, isopropyl and n-butyl. The flavanone schmidt rearrangement derivative is a rearrangement compound obtained by schmidt rearrangement reaction of flavanone, and a derivative obtained by further alkylation. Pharmacological research shows that the compound has strong liver cancer cell proliferation inhibition activity, and can be applied to preparation of a drug for preventing and treating liver cancer.

The invention relates to a fixed-point propynylation modified 3-deoxy anthocyanin derivative, the molecular formula of the derivative is C21H15ClO4, and the chemical name of the derivative is 2-(4-hydroxyphenyl)-5, 7-bis (propyl-2-alkyne-1-yloxy) benzopyran chloride. The invention provides a preparation method of the 3-deoxy anthocyanin derivative, and effectively solves the problems that natural 3-deoxy anthocyanin is low in content and difficult to extract. The invention provides application of the 3-deoxy anthocyanin derivative in preparation of drugs for treating cervical cancer. The invention also provides a pharmaceutical composition for treating cervical cancer. The pharmaceutical composition comprises an effective dose of 3-deoxy anthocyanin derivative and 5-fluorouracil. The 3-deoxy anthocyanin derivative can be used as an effective anti-tumor compound for preparing a medicine for treating cervical cancer or an adjuvant therapy medicine for synergistically enhancing the anti-tumor activity of 5-fluorouracil.