81 results about "Malonate" patented technology

The invention belongs to the technical field of fine chemical engineering, and discloses a synthesis method of a malonate compound, which comprises the following steps: under the action of a heterogeneous catalyst, carrying out hydrolysis-esterification reaction on cyanoacetic acid and alcohol, and after the reaction is finished, carrying out post-treatment to obtain the malonate compound, the heterogeneous catalyst comprises a carrier and an active component; the active component comprises ionic liquid and active metal; the carrier is an ordered mesoporous material; the active metal is alkaline earth metal. According to the method, malonate products can be obtained, the problems of low yield, serious equipment corrosion and large amount of three wastes are solved, efficient synthesis of malonate compounds is realized, meanwhile, the production efficiency is improved, and the environmental pollution is greatly reduced.

The application belongs to the field of organic synthesis, and discloses a method for preparing chiral 2-(1,3-diarylallyl)malonate by using a Pd / phosphine oxygen bidentate phosphine phenol ligand catalysis, which comprises the following steps: under a protective atmosphere, mixing P, O-bidentate phosphine phenol ligand, a palladium catalyst, N, O-bis(trimethylsilyl)acetamide, a malonate nucleophilic reagent and an allyl acetate electrophilic reagent in dichloromethane, and reacting to obtain chiral 2-(1,3-diarylallyl)malonate product. The system has the advantages of high enantioselectivity, high catalytic efficiency, wide substrate application range and mild conditions.

The application relates to a low-temperature calcined ytterbium oxide powder and a preparation method thereof, and belongs to the technical field of metal powder processing. The preparation method comprises the following steps: reacting ytterbium carbonate with malonic acid in an aqueous solution to generate a ytterbium malonate precursor; dispersing the ytterbium malonate precursor in a buffer solution, adding a dopamine salt for polymerization coating, and forming a polydopamine coating layer on the surface of the particles; and calcining the coated compound at 500-750 DEG C to obtain the ytterbium oxide powder. The ytterbium malonate is used to replace the traditional ytterbium carbonate precursor, so that the thermal decomposition temperature can be effectively reduced; the carbon coating layer formed by carbonization of the polydopamine plays a particle spacing protection role in the calcination process, effectively inhibits excessive grain growth and hard agglomeration, and high-dispersity and high-purity ytterbium oxide powder can be obtained at a low temperature. The method has low raw material cost, simple and controllable process, is green and environment-friendly, and is suitable for large-scale industrial production.

This invention relates to the field of chemical synthesis, specifically to a malonate dithioester compound, its preparation method, and its uses. The structural formula of the malonate dithioester derivative of this invention is shown in Formula I. The malonate dithioester compound of this invention is more stable than malonyl chloride and has the advantage of higher reactivity than ordinary malonate ester derivatives, and can be used as an excellent intermediate for the synthesis of pyrido[1,2-α]pyrimidinone mesoionic compounds.

The present disclosure provides methods for utilizing genetically modified microbes to co-produce 3-hydroxypropionic acid (3-HP) and acetyl-CoA, and derivatives thereof from malonate semialdehyde as a common single intermediate. The disclosure further provides modified microbe that co-produce the 3-HP and acetyl-CoA derivatives from malonate semialdehyde.

The present application relates to phenylethyl malonic acid diethyl ester heating technical field, specifically, it is a kind of phenylethyl malonic acid diethyl ester reaction heating device capable of uniform heating.It includes heating tank, feeding opening, discharge port and heater, heating tank is fixedly provided with sleeve inside, the sleeve is used to separate the inner wall of heating tank and sleeve into liquid storage cavity and shunt cavity, liquid storage cavity is located above shunt cavity, auxiliary liquid mixing stirring mechanism is arranged in the inner ring of sleeve, reciprocating mechanism is arranged at the top end of sleeve inside and the end of stirring mechanism.Liquid inside the sleeve is guided into the liquid storage cavity, then steam in the heater flows outward through shunt ring and steam pipe, the flowing steam can continuously conduct heat to the shunt ring, the shunt ring conducts heat to the sprayed liquid, and the sprayed liquid is divided into two streams under the action of shunt ring, so that the contact area of liquid and shunt ring is increased, thereby improving the efficiency of heat transfer and enhancing the uniformity of heat conduction.

The invention discloses an organic-inorganic hybrid malonate polar crystal material as well as a preparation method and application thereof, and belongs to the technical field of optical crystal materials. The chemical formula of the organic and inorganic hybrid malonate polar crystal material is RbLi (C3H2O4). H2O. The invention further discloses a preparation method of the organic and inorganic hybrid malonate polar crystal material. The invention also discloses a preparation method and application of the organic-inorganic hybrid malonate polar crystal material. According to the crystal material, flexible malonic acid radical anions are used as polar functional elements, the malonic acid radical is effectively induced to generate moderate structural distortion by utilizing a synergistic cation regulation strategy of Rb < + > and Li < + >, so that the crystal is stably crystallized in a polar space group, and meanwhile, the crystal material shows excellent nonlinear optical performance and is wide in application prospect.

Disclosed in the present invention is a process method for preparing fluopyram. The process method comprises the following steps: in the presence of a solvent 1, the compound potassium dimethyl 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]malonate reacting with a compound 1-D in a reaction vessel to obtain an intermediate compound, then distilling, and recovering the solvent 1, wherein the intermediate compound does not need to be purified; then adding water, a base, and a solvent 2 to the reaction vessel for reaction; after the reaction is finished, adjusting the pH, and continuing reaction; and after the reaction is finished, performing work-up to obtain the product fluopyram. The solvent 1 is selected from acetate solvents having a boiling point ranging from 40ºC to 110ºC at room temperature and atmospheric pressure. The process method of the present invention is simple, has high overall yield, and low cost, the quality of the product is stable and meets standards, and fluopyram is prepared in one pot, thereby facilitating reduction of the number of production devices, reducing investment, reducing costs, and increasing efficiency, and facilitating large-scale commercial production.

To provide a crystal of 2 - (4-acetylbenzyl) - 3 - ((4-fluorophenyl) amino) - 577 - trimethyl-7, 8-dihydro-pyrazolo-imidazo [1, 2-a] 2H [4, 3-e] pyrimidin-4 (5H) - one.SOLUTION: Provided is a crystal of an acid addition salt form selected from, for example, succinate form, citrate form, adipate form, tartrate form (e.g., L-tartrate form), malate form, gluconate form (e.g., D-gluconate form), maleate form, fumarate form, aspartate form (e.g., L-aspartate form), hippurate form, sebacate form, glycolate form, galactarate form, benzoate form, pamoate form, oxalate form and malonate form.SELECTED DRAWING: None

The invention discloses a synthesis method of 6-pentyl-2H-pyran-2-ketone, which comprises the following steps: step 1, reacting n-hexanoic acid or n-hexanoyl chloride with a malonate compound to obtain a compound a; step 2, carrying out carbonyl ketal protection reaction on the compound a to obtain a compound b; 3, the compound b is subjected to a reduction reaction, and a compound c is obtained; 4, the compound c is subjected to an oxidation reaction, and a compound d is obtained; 5, the compound d is subjected to a Wittig reaction, and a compound e is obtained; step 6, hydrolyzing the compound e, and removing a protecting group to obtain a compound f; and step 7, carrying out cyclization on the compound f, so as to obtain the 6-amyl-2H-pyran-2-one. According to the method, n-hexanoic acid (or n-hexanoyl chloride) serves as a starting raw material, 6PP is prepared through decarboxylation, ketal protection, reduction, oxidation, wittig reaction, hydrolysis deprotection and cyclization, the raw materials are cheap and easy to obtain, reaction conditions are mild, and the method is environmentally friendly and suitable for industrial production.

The invention discloses a kind of ethyl benzoate and its preparation method, belong to the field of fine chemical preparation. The preparation method of ethyl benzoate is, in the first step, acrolein and ethyl malonate are subjected to Kneuwengel condensation reaction to generate enester under triethylenediamine catalyst; In the second step, the diene ester and acrolein generated by the first step undergo Diels-Alder reaction to obtain cyclohexene carboxylate substituted with aldehyde group; In the third step, the cyclohexene carboxylate substituted with aldehyde group is subjected to decarbonylation and dehydrogenation reaction to generate ethyl benzoate under metal catalyst. The reaction conditions of the present invention are simple, the catalyst is simple and easy to obtain, and the cost is low. It is a method for synthesizing spices and flavors through a biomass route with great industrialization prospects.

A lithium secondary battery electrolyte solution includes an organic solvent and a first additive, a second additive, and an electrolyte salt that are dissolved in the organic solvent. The organic solvent includes a carboxylate solvent. A mass percent W1 of the carboxylate solvent in the organic solvent is 20% to 80%. The first additive includes one or more of monofluorophosphate, difluorophosphate, tetrafluoroborate, fluorosulfonate, oxalate borate, malonate borate, oxalate phosphate, or malonate phosphate. The second additive includes one or more of vinylene carbonate or a derivative thereof, or ethylene carbonate or a derivative thereof. The mass percent of the first additive and the mass percent of the second additive in the electrolyte solution are W2 or W3 respectively, satisfying: 0.035≤(W2+W3) / W1≤0.15.

The present invention discloses a method for preparing an indole-3-ylalkyl malonate compound. The method uses economical, cheap and readily available reaction raw materials, and is carried out under mild electrochemical conditions by reacting C (sp) with three components. 3 )–H / C(sp 2 )–H functionalization reaction, one-step construction to obtain indole-3-alkyl malonate compounds. This method is through C(sp 3 )‑H / C(sp 2 )-H functionalization regioselective pathway, with H2 as the only theoretical byproduct. Mechanistic studies suggest that the reaction proceeds via C(sp 3 )-H bond oxidation to generate alkyl radicals, radical addition to C=C bond, single electron oxidation and C(sp 2 Compared with existing methods, the preparation method of the present invention has the advantages of cheap and readily available raw materials, a wide range of reaction substrates, high yield of target products and good atom economy of the reaction.

The application discloses an asymmetric catalytic hydrogenation method of indolocyclopentenyl malonate and application thereof. The method comprises the following steps: in the presence of hydrogen atmosphere, a chiral Ir-SpiroPAP catalyst, a base and a solvent, performing asymmetric catalytic hydrogenation on indolocyclopentenyl malonate to obtain indolocyclopentenyl malonate. The indolocyclopentenyl malonate containing one tertiary carbon chiral center prepared by the method can be used as a key chiral raw material for asymmetric synthesis of a chiral drug Velsipity (Etrasimod). The method has higher enantioselectivity, lower catalyst consumption and a wide substrate application range.

Disclosed are chromane compounds, analogs thereof, and methods of their synthesis and use. The compounds may be synthesized by methods involving reductive annulations of arylidene malonates with unsaturated electrophiles using photoredox / Lewis acid cooperative catalysis. The compounds may be formulated in a pharmaceutical composition for treating one of the aforementioned diseases or disorders.

This invention discloses a controlled-release nitrogen fertilizer containing organic acid salt signaling substances. From the inside out, it comprises urea particles, a cross-linked material-trace element mixture, molten urea, and a bio-based polyurethane coating material. The cross-linked material-trace element mixture is a porous cross-linked material loaded with trace elements. The porous cross-linked material is obtained by cross-linking alginic acid and organic acid salts through a cross-linking agent. The organic acid salts are selected from at least one of sodium citrate, sodium fumarate, sodium maleate, sodium malonate, and sodium succinate. The trace elements are selected from at least one of zinc, cobalt, molybdenum, and iron. This invention, through alginic acid-organic acid salt cross-linking, precise loading of trace elements, and multi-layer coating technology, produces a novel controlled-release fertilizer that combines pH responsiveness, environmental resistance, and high nutrient utilization. Nutrient release can be dynamically controlled according to soil pH and crop needs, reducing nutrient loss and environmental pollution, meeting the needs of green agriculture development, and providing an innovative solution for improving fertilizer utilization and crop yield.

The invention relates to a method for constructing a spectrum-effect relationship of dried orange peel from different producing areas based on electrochemical fingerprints in combination with antioxidant activity. The method comprises the following steps: establishing electrochemical fingerprints of dried orange peel from different producing areas under the conditions that the temperature is 35 DEG C, the concentration of sulfuric acid is 1mol / L, the concentration of ceric ammonium sulfate is 0.005 mol / L, the concentration of malonic acid is 0.45 mol / L and the concentration of sodium bromate is 0.3 mol / L; an ABTS free radical scavenging rate method with high sensitivity and stability is selected for antioxidant activity evaluation. Meanwhile, a rapid and accurate spectrum-activity relationship method is established by analyzing the spectrum-activity relationship between the electrochemical fingerprints of the dried orange peel from different producing areas and the semi-inhibitory concentration of the ABTS free radical scavenging rate in combination with Pearson correlation. The method has certain scientific value and wide application value.

The invention discloses a polyether malonate fullerene derivative and a preparation method and application thereof, and belongs to the technical field of photovoltaic materials.The preparation method comprises the steps that firstly, a polyether malonate derivative is prepared, then the obtained polyether malonate derivative reacts with DBU, I2 and C60 under the water-free and oxygen-free conditions to obtain the polyether malonate fullerene derivative, and finally the polyether malonate fullerene derivative is obtained. The synthesis method is simple, application is convenient, operability is high, reaction raw materials are low in price and easy to obtain, the process for preparing a perovskite solar cell by using the polyether malonate fullerene derivative prepared through the method as an electron transport material is green and environmentally friendly, and the corresponding perovskite solar cell has the advantages of being high in device efficiency and stability.

The application discloses plant oil-containing insulating oil and a preparation method and application thereof, and belongs to the technical field of lubricating oil, and is used for solving the problems that plant oil-type insulating oil is prone to solidification at low temperature, and antioxidation stability and flame retardation need to be further improved in the prior art, wherein the preparation method of the plant oil-containing insulating oil comprises the following steps: uniformly mixing dimethyl 2-(4-aminophenyl)malonate and 4-(1-hydroxyethyl)-2,6-dimethoxyphenol in an inert gas atmosphere, adding dibutyl tin dilaurate, stirring, heating, and reacting to obtain modified steric phenol; mixing N,N-dimethylformamide, the modified steric phenol and di-tert-butyl chloromethyl phosphate, adding triethylamine, heating to reflux, stopping the reaction, washing, and drying to obtain a modified antioxidant; the plant oil-containing insulating oil prepared by the application has environmental protection, antioxidation and certain flame retardation, and is not prone to solidification at low temperature, these characteristics expand the application range of the insulating oil, and meet more strict application requirements.

本发明属于化学传感技术领域，具体涉及一种基于逻辑门检测 HeLa 细胞内阴离子的 NBD 锌配合物双模式光学探针及其制备方法和应用。所述传探针分子式为Zn(NBD‑BPHA)I2，其合成方法简单，实施可行性高，成本低廉，灵敏度、选择性、稳定性高，可同时检测丙二酸根、草酸根和焦磷酸根阴离子，为丙二酸根、草酸根和焦磷酸根阴离子检测领域的应用提供了一种新方法。

The utility model discloses a rectifying still for producing diethyl phenylethyl malonate, which is characterized in that a plurality of layers of pore plates are arranged in a still body through an annular support plate, a main shaft penetrates through guide sleeves of the pore plates, and after entering the still body, a diethyl phenylethyl malonate crude product reacts with rising steam, so that gas phase and liquid phase separation is realized; a gas phase is discharged from a gas phase outlet in the top, a liquid phase flows to the bottom of the kettle body, and in the process, when liquid phase stirring and heating in the kettle body are carried out through a stirring paddle at the bottom, the heat exchange effect is improved, so that the gas phase separation effect during boiling is improved, contact between steam and liquid is realized through a pore plate, and the gas-liquid separation effect is improved; a stirring rod is mounted above each layer of pore plate through a main shaft, so that the contact area of steam and the crude product of the diethyl phenylethylmalonate is greatly increased through stirring of the stirring rods, the gas-phase separation effect of the diethyl phenylethylmalonate is further improved, the rectification frequency is reduced, and the efficiency is improved.

The invention discloses insulating oil containing vegetable oil as well as a preparation method and application thereof, belongs to the technical field of lubricating oil, and aims at solving the problems that vegetable oil type insulating oil in the prior art is easy to solidify at low temperature, and the anti-oxidation stability and the flame retardance need to be further improved. The preparation method of the insulating oil containing the vegetable oil comprises the following steps: uniformly mixing dimethyl 2-(4-aminophenyl) malonate and 4-(1-ethoxyl)-2, 6-dimethoxyphenol in an inert gas atmosphere, adding dibutyltin dilaurate, stirring, heating and reacting to obtain modified sterically hindered phenol; mixing N, N-dimethylformamide, the modified sterically hindered phenol and di-tert-butyl chloromethyl phosphate, adding triethylamine, carrying out heating reflux, and after the reaction is finished, washing and drying to obtain a modified antioxidant; the vegetable oil-containing insulating oil prepared by the invention has environmental protection property, oxidation resistance and certain flame retardancy, and is not easy to solidify at low temperature, so that the application range of the insulating oil is expanded, and stricter application requirements are met.

The present invention relates to a method for recovering monopropyl malonate of the chemical structural formula Ⅰ: Select 1-chloropropane and diethyl malonate in DMF, and under the action of potassium carbonate or sodium carbonate and quaternary ammonium salt, carry out dipropylation to obtain dipropyl malonate; in the process of preparing dipropyl malonate, add an alcohol solvent to the filter cake inorganic salt [residual dipropyl malonate monoester (Ⅲ)], and obtain the monopropyl malonate of the formula Ⅰ through pulping, acidification, crystallization, filtration and low-temperature vacuum drying: where M is selected from K or Na; R 1 is selected from: a C1-C5 straight-chain alkyl group or a C3-C5 branched-chain alkyl group; the alcohol solvent is selected from methanol, ethanol, a C3-C6 straight-chain or C3-C6 branched-chain monohydric alcohol, ethylene glycol, a C3-C5 straight-chain dihydric alcohol or a C4-C5 branched-chain dihydric alcohol; H + is selected from hydrochloric acid, phosphoric acid or sulfuric acid.

The application discloses a preparation method of 2-methyl-3-nitro-4-hydroxypyridine, which comprises the following steps: taking 2-chloro-4-amino pyridine as raw material, and first reacting with mixed acid to obtain an intermediate 2-chloro-3-nitro-4-amino pyridine; the obtained intermediate is first reacted with dimethyl / ethyl malonate to obtain dimethyl / ethyl 2-(4-amino-3-nitro pyridine-2-yl) malonate, and then the dimethyl / ethyl 2-(4-amino-3-nitro pyridine-2-yl) malonate is subjected to a hydrolysis reaction to obtain an intermediate 2-methyl-3-nitro-4-amino pyridine; and the intermediate 2-methyl-3-nitro-4-amino pyridine is subjected to diazotization and hydrolysis reactions to obtain 2-methyl-3-nitro-4-hydroxypyridine. The target product is obtained by adopting a three-step method, raw materials are cheap and easy to obtain, the process is simple and easy to operate, the cost is low, the product has high yield and purity, the method is suitable for large-scale production, and has a wide application prospect.

This invention belongs to the field of supercapacitor technology. It discloses a method for preparing a Russian nesting doll-shaped porous carbon material and its application in a high-performance potassium-ion hybrid capacitor. The method includes simultaneously adding dihydrazine malonate and potassium hydroxide in a 1:1 molar ratio to a ball mill, grinding and aerating for at least 30 minutes, and transferring the resulting powder into a tube furnace under a N2 atmosphere at 2... o C min ‑1 Heating rate to 800 o C was calcined for 0.5 hours to obtain the carbonized product, which was then treated with deionized water and HCl (1 mol L). ‑1 The carbonized products were washed multiple times and freeze-dried for two days to obtain the final product. A potassium-ion hybrid capacitor assembled using Russian nesting doll-shaped porous carbon as the negative electrode and activated carbon as the positive electrode exhibits high energy density, ultra-high power output, and long cycle life, highlighting the superiority of the Russian nesting doll-shaped porous structure. This invention is simple to operate and environmentally friendly, and provides important guidance for the design of three-dimensional pore structures, especially multi-channel pore structures.

Disclosed in the present invention is a process for preparing a key intermediate of fluopyram. The key intermediate is dimethyl [3-chloro-5-(trifluoromethyl)pyridin-2-yl]({[2-(trifluoromethyl)benzoyl]amino}methyl)malonate. The process comprises the following steps: in the presence of a solvent 1, reacting the compound potassium dimethyl 2-[3-chloro-5-(trifluoromethyl)pyridyl]malonate with the compound 1-D in a reaction container, and recovering the solvent 1 by means of distillation, so as to obtain the intermediate compound, wherein the solvent 1 is selected from acetic ester solvents having a boiling point range of 40-110°C at a normal temperature and a normal pressure. The process of the present invention is simple and convenient, the total yield is high, the solvent is easy to recover, and the product purity is high; the intermediate does not require any post-purification treatment, and can be directly used for the synthesis of fluopyram; and the process can be amplified, and is beneficial for cost reduction, efficiency improvement and commercial mass production.

The invention belongs to the technical field of medicines, and relates to a malonate group-containing 2, 3-disubstituted indole derivative as shown in a general formula I, and a stereoisomer and pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof, and substituent groups R, R ', R1, R2 and R3 are defined in the specification. The invention also relates to a method for preparing the compound as shown in the general formula I and related application of the compound in preparation, treatment and prevention of inflammatory diseases, antitumor drugs and bactericides. # imgabs0 #

The invention discloses a method for separating copper-sulfur minerals through pre-oxidation-xanthate-free flotation, and belongs to the technical field of ore separation. The method comprises the steps that firstly, sodium percarbonate is added into copper-sulfur mineral primary ore pulp for pulp mixing, then dibutyl oxalate or diisopropyl malonate is added into the ore pulp to serve as a collecting agent, and copper concentrate and tailings are obtained after one-time roughing, two-time sweeping and two-time concentration grading operation. The high-selectivity ester collecting agent is adopted, the selective collecting capacity and foamability are both considered, copper-sulfur mineral flotation separation can be achieved under the lime-free, high-alkali and xanthate-free conditions, the problems of high-alkali pollution, poor xanthate selectivity and the like in a traditional copper-sulfur separation process are effectively solved, and the method has the multiple advantages of being low in cost, simple in process, environmentally friendly and the like.

The invention relates to the use of at least one malonate of formula (I) as a stabiliser for storage stability in compositions containing isocyanate groups, and to a curable composition obtained from the use according to the invention. The malonate of formula (I) makes possible one-component elastic adhesives with very good storage stability, which adhere excellently to glass and ceramic substrates without pretreatment using primers. Such an adhesive is particularly suitable for bonding panes in the vehicle industry.

The application belongs to the technical field of crystal form drug molecules, and relates to zolpidem salts, and a preparation method and application thereof. The application specifically provides zolpidem oxalate, zolpidem fumarate, zolpidem malonate and zolpidem-5-sulfosalicylate methanol compound. The method for preparing the zolpidem salt provided by the application is simple to operate, and the prepared crystal has high purity. The zolpidem salt provided by the application has good chemical stability and good solubility.