60 results about "Malonate" patented technology

The invention belongs to the technical field of fine chemical engineering, and discloses a synthesis method of a malonate compound, which comprises the following steps: under the action of a heterogeneous catalyst, carrying out hydrolysis-esterification reaction on cyanoacetic acid and alcohol, and after the reaction is finished, carrying out post-treatment to obtain the malonate compound, the heterogeneous catalyst comprises a carrier and an active component; the active component comprises ionic liquid and active metal; the carrier is an ordered mesoporous material; the active metal is alkaline earth metal. According to the method, malonate products can be obtained, the problems of low yield, serious equipment corrosion and large amount of three wastes are solved, efficient synthesis of malonate compounds is realized, meanwhile, the production efficiency is improved, and the environmental pollution is greatly reduced.

The application belongs to the field of organic synthesis, and discloses a method for preparing chiral 2-(1,3-diarylallyl)malonate by using a Pd / phosphine oxygen bidentate phosphine phenol ligand catalysis, which comprises the following steps: under a protective atmosphere, mixing P, O-bidentate phosphine phenol ligand, a palladium catalyst, N, O-bis(trimethylsilyl)acetamide, a malonate nucleophilic reagent and an allyl acetate electrophilic reagent in dichloromethane, and reacting to obtain chiral 2-(1,3-diarylallyl)malonate product. The system has the advantages of high enantioselectivity, high catalytic efficiency, wide substrate application range and mild conditions.

The application relates to a low-temperature calcined ytterbium oxide powder and a preparation method thereof, and belongs to the technical field of metal powder processing. The preparation method comprises the following steps: reacting ytterbium carbonate with malonic acid in an aqueous solution to generate a ytterbium malonate precursor; dispersing the ytterbium malonate precursor in a buffer solution, adding a dopamine salt for polymerization coating, and forming a polydopamine coating layer on the surface of the particles; and calcining the coated compound at 500-750 DEG C to obtain the ytterbium oxide powder. The ytterbium malonate is used to replace the traditional ytterbium carbonate precursor, so that the thermal decomposition temperature can be effectively reduced; the carbon coating layer formed by carbonization of the polydopamine plays a particle spacing protection role in the calcination process, effectively inhibits excessive grain growth and hard agglomeration, and high-dispersity and high-purity ytterbium oxide powder can be obtained at a low temperature. The method has low raw material cost, simple and controllable process, is green and environment-friendly, and is suitable for large-scale industrial production.

This invention relates to the field of chemical synthesis, specifically to a malonate dithioester compound, its preparation method, and its uses. The structural formula of the malonate dithioester derivative of this invention is shown in Formula I. The malonate dithioester compound of this invention is more stable than malonyl chloride and has the advantage of higher reactivity than ordinary malonate ester derivatives, and can be used as an excellent intermediate for the synthesis of pyrido[1,2-α]pyrimidinone mesoionic compounds.

The present application relates to phenylethyl malonic acid diethyl ester heating technical field, specifically, it is a kind of phenylethyl malonic acid diethyl ester reaction heating device capable of uniform heating.It includes heating tank, feeding opening, discharge port and heater, heating tank is fixedly provided with sleeve inside, the sleeve is used to separate the inner wall of heating tank and sleeve into liquid storage cavity and shunt cavity, liquid storage cavity is located above shunt cavity, auxiliary liquid mixing stirring mechanism is arranged in the inner ring of sleeve, reciprocating mechanism is arranged at the top end of sleeve inside and the end of stirring mechanism.Liquid inside the sleeve is guided into the liquid storage cavity, then steam in the heater flows outward through shunt ring and steam pipe, the flowing steam can continuously conduct heat to the shunt ring, the shunt ring conducts heat to the sprayed liquid, and the sprayed liquid is divided into two streams under the action of shunt ring, so that the contact area of liquid and shunt ring is increased, thereby improving the efficiency of heat transfer and enhancing the uniformity of heat conduction.

The invention discloses an organic-inorganic hybrid malonate polar crystal material as well as a preparation method and application thereof, and belongs to the technical field of optical crystal materials. The chemical formula of the organic and inorganic hybrid malonate polar crystal material is RbLi (C3H2O4). H2O. The invention further discloses a preparation method of the organic and inorganic hybrid malonate polar crystal material. The invention also discloses a preparation method and application of the organic-inorganic hybrid malonate polar crystal material. According to the crystal material, flexible malonic acid radical anions are used as polar functional elements, the malonic acid radical is effectively induced to generate moderate structural distortion by utilizing a synergistic cation regulation strategy of Rb < + > and Li < + >, so that the crystal is stably crystallized in a polar space group, and meanwhile, the crystal material shows excellent nonlinear optical performance and is wide in application prospect.

Disclosed in the present invention is a process method for preparing fluopyram. The process method comprises the following steps: in the presence of a solvent 1, the compound potassium dimethyl 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]malonate reacting with a compound 1-D in a reaction vessel to obtain an intermediate compound, then distilling, and recovering the solvent 1, wherein the intermediate compound does not need to be purified; then adding water, a base, and a solvent 2 to the reaction vessel for reaction; after the reaction is finished, adjusting the pH, and continuing reaction; and after the reaction is finished, performing work-up to obtain the product fluopyram. The solvent 1 is selected from acetate solvents having a boiling point ranging from 40ºC to 110ºC at room temperature and atmospheric pressure. The process method of the present invention is simple, has high overall yield, and low cost, the quality of the product is stable and meets standards, and fluopyram is prepared in one pot, thereby facilitating reduction of the number of production devices, reducing investment, reducing costs, and increasing efficiency, and facilitating large-scale commercial production.

To provide a crystal of 2 - (4-acetylbenzyl) - 3 - ((4-fluorophenyl) amino) - 577 - trimethyl-7, 8-dihydro-pyrazolo-imidazo [1, 2-a] 2H [4, 3-e] pyrimidin-4 (5H) - one.SOLUTION: Provided is a crystal of an acid addition salt form selected from, for example, succinate form, citrate form, adipate form, tartrate form (e.g., L-tartrate form), malate form, gluconate form (e.g., D-gluconate form), maleate form, fumarate form, aspartate form (e.g., L-aspartate form), hippurate form, sebacate form, glycolate form, galactarate form, benzoate form, pamoate form, oxalate form and malonate form.SELECTED DRAWING: None

The invention discloses a synthesis method of 6-pentyl-2H-pyran-2-ketone, which comprises the following steps: step 1, reacting n-hexanoic acid or n-hexanoyl chloride with a malonate compound to obtain a compound a; step 2, carrying out carbonyl ketal protection reaction on the compound a to obtain a compound b; 3, the compound b is subjected to a reduction reaction, and a compound c is obtained; 4, the compound c is subjected to an oxidation reaction, and a compound d is obtained; 5, the compound d is subjected to a Wittig reaction, and a compound e is obtained; step 6, hydrolyzing the compound e, and removing a protecting group to obtain a compound f; and step 7, carrying out cyclization on the compound f, so as to obtain the 6-amyl-2H-pyran-2-one. According to the method, n-hexanoic acid (or n-hexanoyl chloride) serves as a starting raw material, 6PP is prepared through decarboxylation, ketal protection, reduction, oxidation, wittig reaction, hydrolysis deprotection and cyclization, the raw materials are cheap and easy to obtain, reaction conditions are mild, and the method is environmentally friendly and suitable for industrial production.

The invention discloses a kind of ethyl benzoate and its preparation method, belong to the field of fine chemical preparation. The preparation method of ethyl benzoate is, in the first step, acrolein and ethyl malonate are subjected to Kneuwengel condensation reaction to generate enester under triethylenediamine catalyst; In the second step, the diene ester and acrolein generated by the first step undergo Diels-Alder reaction to obtain cyclohexene carboxylate substituted with aldehyde group; In the third step, the cyclohexene carboxylate substituted with aldehyde group is subjected to decarbonylation and dehydrogenation reaction to generate ethyl benzoate under metal catalyst. The reaction conditions of the present invention are simple, the catalyst is simple and easy to obtain, and the cost is low. It is a method for synthesizing spices and flavors through a biomass route with great industrialization prospects.

A lithium secondary battery electrolyte solution includes an organic solvent and a first additive, a second additive, and an electrolyte salt that are dissolved in the organic solvent. The organic solvent includes a carboxylate solvent. A mass percent W1 of the carboxylate solvent in the organic solvent is 20% to 80%. The first additive includes one or more of monofluorophosphate, difluorophosphate, tetrafluoroborate, fluorosulfonate, oxalate borate, malonate borate, oxalate phosphate, or malonate phosphate. The second additive includes one or more of vinylene carbonate or a derivative thereof, or ethylene carbonate or a derivative thereof. The mass percent of the first additive and the mass percent of the second additive in the electrolyte solution are W2 or W3 respectively, satisfying: 0.035≤(W2+W3) / W1≤0.15.

The present invention discloses a method for preparing an indole-3-ylalkyl malonate compound. The method uses economical, cheap and readily available reaction raw materials, and is carried out under mild electrochemical conditions by reacting C (sp) with three components. 3 )–H / C(sp 2 )–H functionalization reaction, one-step construction to obtain indole-3-alkyl malonate compounds. This method is through C(sp 3 )‑H / C(sp 2 )-H functionalization regioselective pathway, with H2 as the only theoretical byproduct. Mechanistic studies suggest that the reaction proceeds via C(sp 3 )-H bond oxidation to generate alkyl radicals, radical addition to C=C bond, single electron oxidation and C(sp 2 Compared with existing methods, the preparation method of the present invention has the advantages of cheap and readily available raw materials, a wide range of reaction substrates, high yield of target products and good atom economy of the reaction.

The application discloses an asymmetric catalytic hydrogenation method of indolocyclopentenyl malonate and application thereof. The method comprises the following steps: in the presence of hydrogen atmosphere, a chiral Ir-SpiroPAP catalyst, a base and a solvent, performing asymmetric catalytic hydrogenation on indolocyclopentenyl malonate to obtain indolocyclopentenyl malonate. The indolocyclopentenyl malonate containing one tertiary carbon chiral center prepared by the method can be used as a key chiral raw material for asymmetric synthesis of a chiral drug Velsipity (Etrasimod). The method has higher enantioselectivity, lower catalyst consumption and a wide substrate application range.

Disclosed are chromane compounds, analogs thereof, and methods of their synthesis and use. The compounds may be synthesized by methods involving reductive annulations of arylidene malonates with unsaturated electrophiles using photoredox / Lewis acid cooperative catalysis. The compounds may be formulated in a pharmaceutical composition for treating one of the aforementioned diseases or disorders.

This invention discloses a controlled-release nitrogen fertilizer containing organic acid salt signaling substances. From the inside out, it comprises urea particles, a cross-linked material-trace element mixture, molten urea, and a bio-based polyurethane coating material. The cross-linked material-trace element mixture is a porous cross-linked material loaded with trace elements. The porous cross-linked material is obtained by cross-linking alginic acid and organic acid salts through a cross-linking agent. The organic acid salts are selected from at least one of sodium citrate, sodium fumarate, sodium maleate, sodium malonate, and sodium succinate. The trace elements are selected from at least one of zinc, cobalt, molybdenum, and iron. This invention, through alginic acid-organic acid salt cross-linking, precise loading of trace elements, and multi-layer coating technology, produces a novel controlled-release fertilizer that combines pH responsiveness, environmental resistance, and high nutrient utilization. Nutrient release can be dynamically controlled according to soil pH and crop needs, reducing nutrient loss and environmental pollution, meeting the needs of green agriculture development, and providing an innovative solution for improving fertilizer utilization and crop yield.

The invention discloses a polyether malonate fullerene derivative and a preparation method and application thereof, and belongs to the technical field of photovoltaic materials.The preparation method comprises the steps that firstly, a polyether malonate derivative is prepared, then the obtained polyether malonate derivative reacts with DBU, I2 and C60 under the water-free and oxygen-free conditions to obtain the polyether malonate fullerene derivative, and finally the polyether malonate fullerene derivative is obtained. The synthesis method is simple, application is convenient, operability is high, reaction raw materials are low in price and easy to obtain, the process for preparing a perovskite solar cell by using the polyether malonate fullerene derivative prepared through the method as an electron transport material is green and environmentally friendly, and the corresponding perovskite solar cell has the advantages of being high in device efficiency and stability.

The application discloses plant oil-containing insulating oil and a preparation method and application thereof, and belongs to the technical field of lubricating oil, and is used for solving the problems that plant oil-type insulating oil is prone to solidification at low temperature, and antioxidation stability and flame retardation need to be further improved in the prior art, wherein the preparation method of the plant oil-containing insulating oil comprises the following steps: uniformly mixing dimethyl 2-(4-aminophenyl)malonate and 4-(1-hydroxyethyl)-2,6-dimethoxyphenol in an inert gas atmosphere, adding dibutyl tin dilaurate, stirring, heating, and reacting to obtain modified steric phenol; mixing N,N-dimethylformamide, the modified steric phenol and di-tert-butyl chloromethyl phosphate, adding triethylamine, heating to reflux, stopping the reaction, washing, and drying to obtain a modified antioxidant; the plant oil-containing insulating oil prepared by the application has environmental protection, antioxidation and certain flame retardation, and is not prone to solidification at low temperature, these characteristics expand the application range of the insulating oil, and meet more strict application requirements.

本发明属于化学传感技术领域，具体涉及一种基于逻辑门检测 HeLa 细胞内阴离子的 NBD 锌配合物双模式光学探针及其制备方法和应用。所述传探针分子式为Zn(NBD‑BPHA)I2，其合成方法简单，实施可行性高，成本低廉，灵敏度、选择性、稳定性高，可同时检测丙二酸根、草酸根和焦磷酸根阴离子，为丙二酸根、草酸根和焦磷酸根阴离子检测领域的应用提供了一种新方法。

The application discloses a preparation method of 2-methyl-3-nitro-4-hydroxypyridine, which comprises the following steps: taking 2-chloro-4-amino pyridine as raw material, and first reacting with mixed acid to obtain an intermediate 2-chloro-3-nitro-4-amino pyridine; the obtained intermediate is first reacted with dimethyl / ethyl malonate to obtain dimethyl / ethyl 2-(4-amino-3-nitro pyridine-2-yl) malonate, and then the dimethyl / ethyl 2-(4-amino-3-nitro pyridine-2-yl) malonate is subjected to a hydrolysis reaction to obtain an intermediate 2-methyl-3-nitro-4-amino pyridine; and the intermediate 2-methyl-3-nitro-4-amino pyridine is subjected to diazotization and hydrolysis reactions to obtain 2-methyl-3-nitro-4-hydroxypyridine. The target product is obtained by adopting a three-step method, raw materials are cheap and easy to obtain, the process is simple and easy to operate, the cost is low, the product has high yield and purity, the method is suitable for large-scale production, and has a wide application prospect.

This invention belongs to the field of supercapacitor technology. It discloses a method for preparing a Russian nesting doll-shaped porous carbon material and its application in a high-performance potassium-ion hybrid capacitor. The method includes simultaneously adding dihydrazine malonate and potassium hydroxide in a 1:1 molar ratio to a ball mill, grinding and aerating for at least 30 minutes, and transferring the resulting powder into a tube furnace under a N2 atmosphere at 2... o C min ‑1 Heating rate to 800 o C was calcined for 0.5 hours to obtain the carbonized product, which was then treated with deionized water and HCl (1 mol L). ‑1 The carbonized products were washed multiple times and freeze-dried for two days to obtain the final product. A potassium-ion hybrid capacitor assembled using Russian nesting doll-shaped porous carbon as the negative electrode and activated carbon as the positive electrode exhibits high energy density, ultra-high power output, and long cycle life, highlighting the superiority of the Russian nesting doll-shaped porous structure. This invention is simple to operate and environmentally friendly, and provides important guidance for the design of three-dimensional pore structures, especially multi-channel pore structures.

Disclosed in the present invention is a process for preparing a key intermediate of fluopyram. The key intermediate is dimethyl [3-chloro-5-(trifluoromethyl)pyridin-2-yl]({[2-(trifluoromethyl)benzoyl]amino}methyl)malonate. The process comprises the following steps: in the presence of a solvent 1, reacting the compound potassium dimethyl 2-[3-chloro-5-(trifluoromethyl)pyridyl]malonate with the compound 1-D in a reaction container, and recovering the solvent 1 by means of distillation, so as to obtain the intermediate compound, wherein the solvent 1 is selected from acetic ester solvents having a boiling point range of 40-110°C at a normal temperature and a normal pressure. The process of the present invention is simple and convenient, the total yield is high, the solvent is easy to recover, and the product purity is high; the intermediate does not require any post-purification treatment, and can be directly used for the synthesis of fluopyram; and the process can be amplified, and is beneficial for cost reduction, efficiency improvement and commercial mass production.

The invention discloses a method for separating copper-sulfur minerals through pre-oxidation-xanthate-free flotation, and belongs to the technical field of ore separation. The method comprises the steps that firstly, sodium percarbonate is added into copper-sulfur mineral primary ore pulp for pulp mixing, then dibutyl oxalate or diisopropyl malonate is added into the ore pulp to serve as a collecting agent, and copper concentrate and tailings are obtained after one-time roughing, two-time sweeping and two-time concentration grading operation. The high-selectivity ester collecting agent is adopted, the selective collecting capacity and foamability are both considered, copper-sulfur mineral flotation separation can be achieved under the lime-free, high-alkali and xanthate-free conditions, the problems of high-alkali pollution, poor xanthate selectivity and the like in a traditional copper-sulfur separation process are effectively solved, and the method has the multiple advantages of being low in cost, simple in process, environmentally friendly and the like.

The invention relates to the use of at least one malonate of formula (I) as a stabiliser for storage stability in compositions containing isocyanate groups, and to a curable composition obtained from the use according to the invention. The malonate of formula (I) makes possible one-component elastic adhesives with very good storage stability, which adhere excellently to glass and ceramic substrates without pretreatment using primers. Such an adhesive is particularly suitable for bonding panes in the vehicle industry.

The application belongs to the technical field of crystal form drug molecules, and relates to zolpidem salts, and a preparation method and application thereof. The application specifically provides zolpidem oxalate, zolpidem fumarate, zolpidem malonate and zolpidem-5-sulfosalicylate methanol compound. The method for preparing the zolpidem salt provided by the application is simple to operate, and the prepared crystal has high purity. The zolpidem salt provided by the application has good chemical stability and good solubility.

The present disclosure belongs to the technical field of battery materials, and particularly relates to a method for preparing iron phosphate dihydrate by using wet-process phosphoric acid, comprising the following steps: (1) mixing a wet-process phosphoric acid solution with an aluminum shielding agent to obtain a mixed solution, and then adding a pH regulator and standing; the aluminum shielding agent is at least one of malonate, succinate and phthalate; (2) performing water bath on the mixed solution obtained in step (1) under stirring, adding iron sulfate to the mixed solution, and then adding iron phosphate dihydrate seeds, and then performing solid-liquid separation after reaction to obtain a solid, and then washing to obtain iron phosphate dihydrate.

The invention discloses a chiral surface active agent for enantioselective reverse micelle extraction. The chiral surfactant for enantioselective reverse micelle extraction is N-alkanoyl substituted chiral amino acid, and the preparation method comprises the following steps: with malonate (S1) as a raw material, carrying out C-alkylation reaction on malonate (S1) and halogenated hydrocarbon under base catalysis to prepare alkyl malonate (S2); s2, carrying out hydrolysis reaction to obtain alkyl malonic acid (S3); s3, performing high-temperature decarboxylation to prepare alkyl acid (S4); s4 is subjected to acylating chlorination and then is subjected to an N-acylation reaction with chiral amino acid, and N-alkanoyl substituted chiral amino acid (S) is obtained. Reverse micelle formed by the chiral surfactant in a non-aqueous solvent insoluble in water is used as a chiral recognition extraction agent, and resolution of a raceme compound can be realized.

This invention relates to a series of malonate borate nonlinear optical crystals, their preparation methods, and applications. The general molecular formula of this series of compounds is AM[C3H2O4]B(OH)3(H2O). x Where A = K, Rb, Cs; M = K, Rb, Cs, x = 0, 1, molecular weight is 242.08–436.72, prepared by room temperature solution method, orthorhombic crystal system, space group P 212121 (No. 19), with cell parameters a = 6.6168(11) - 7.256(3) Å, b = 9.574(5) - 10.271(3) Å, c = 13.0172(12) - 13.984(5) Å. α =90, β =90, gamma =90, Z =4, V=851.3(4)-1042.2(7)Å 3 The series of malonate borate nonlinear optical crystals obtained by this method have advantages such as a wide transmission band, stable physicochemical properties, moderate mechanical hardness, resistance to breakage, and ease of cutting, polishing, and storage. They can withstand 1064nm infrared light incident on AM[C3H2O4]B(OH)3(H2O). x The crystal can produce green frequency-doubled light with a wavelength of 532nm, and the output intensity is about 0.5-1.2 times that of KDP under the same conditions.

The invention discloses a vitamin K2 oil agent, which is prepared from the following components in percentage by mass: 1 to 20.0 percent of vitamin K2, 0.1 to 10.0 percent of antioxidant, 0.1 to 10.0 percent of light protective agent and 60.0 to 98.0 percent of grease. The grease is selected from dicapryl carbonate or isononyl isononanoate or a mixture of the dicapryl carbonate or isononyl isononanoate and other grease, and the light protective agent is selected from caryophyllyl malonate diethylhexyl ester, 2-(4-hydroxy-3, 5-dimethoxy styryl) malonate diisooctyl ester or trimethoxy benzal pentanedione or a mixture of the caryophyllyl malonate diethylhexyl ester, the 2-(4-hydroxy-3, 5-dimethoxy styryl) malonate diisooctyl ester and trimethoxy benzal pentanedione and other light protective agents. The antioxidant is selected from vitamin E or a mixture of vitamin E and other antioxidants. The vitamin K2 oil agent has high activity loading capacity and excellent light / oxidation stability, and the application of the vitamin K2 in cosmetics is promoted.

The present application relates to ethyl malonate mixing technical field, specifically, it relates to a kind of condensation device for reducing mixing time of diethyl phenylethyl malonate production.The condensation device includes mixing bin, condensation kettle, stirring device and storage bin fixedly arranged at the top of mixing bin, the bottom of mixing bin is communicated with condensation kettle with communicating pipe, storage bin is formed with liquid storage cavity and nitrogen cavity for storing raw materials and nitrogen respectively in the inside, and isolating mechanism for separating first mixed liquid and secondary mixed liquid is movably arranged in the inside of mixing bin.The gravity of secondary mixed liquid on the floating plate is used to pressurize first mixed liquid in discharge cavity, at the same time, the gravity of secondary mixed liquid is used to hit reciprocating plate, so that nitrogen in nitrogen cavity is transported into discharge cavity, the pressure in discharge cavity is increased, the speed of liquid discharge is improved, and in the process of first mixed liquid discharge, stirring device can also stir first mixed liquid and secondary mixed liquid simultaneously, so as to shorten mixing time.

The present invention relates to a combination of the following active ingredients: c) in cosmetic excipients a) one or more alkylamide thiazoles and b) diethylhexyl clove subunit malonates.