106 results about "Malonate" patented technology

The invention belongs to the technical field of fine chemical engineering, and discloses a synthesis method of a malonate compound, which comprises the following steps: under the action of a heterogeneous catalyst, carrying out hydrolysis-esterification reaction on cyanoacetic acid and alcohol, and after the reaction is finished, carrying out post-treatment to obtain the malonate compound, the heterogeneous catalyst comprises a carrier and an active component; the active component comprises ionic liquid and active metal; the carrier is an ordered mesoporous material; the active metal is alkaline earth metal. According to the method, malonate products can be obtained, the problems of low yield, serious equipment corrosion and large amount of three wastes are solved, efficient synthesis of malonate compounds is realized, meanwhile, the production efficiency is improved, and the environmental pollution is greatly reduced.

The invention provides a synthesis method of 7-bromo-3, 4-dihydroquinoline-2 (1H)-ketone and the 7-bromo-3, 4-dihydroquinoline-2 (1H)-ketone, and the method specifically comprises the following steps: taking a compound 2-amino-4-bromobenzaldehyde as a raw material, and reacting with isopropyl malonate under a formic acid-triethylamine system to obtain a target compound 7-bromo-3, 4-dihydroquinoline-2 (1H)-ketone. According to the synthetic method, the compound 2-amino-4-bromobenzaldehyde is converted into the compound 7-bromo-3, 4-dihydroquinoline-2 (1H)-ketone through one-step reaction, the reaction condition is mild, aftertreatment and purification are simple, and manufacturability amplification can be achieved; finally, the compound 7-bromo-3, 4-dihydroquinoline-2 (1H)-ketone is prepared through short steps, simple and convenient operation, low cost and relatively mild reaction conditions.

The invention discloses a preparation method of an indole-3-yl alkyl malonate compound and a preparation method of the indole-3-yl alkyl malonate compound. According to the method, reaction raw materials which are economical, cheap and easy to obtain are subjected to a three-component C (sp3)-H / C (sp2)-H functionalization reaction under a mild electrochemical condition, and the indole-3-alkyl malonate compound is obtained through one-step construction. According to the method, a C (sp3)-H / C (sp2)-H functionalization regioselective pathway is adopted, and H2 is a unique theoretical byproduct. Mechanism studies show that the reaction generates alkyl free radicals through C (sp3)-H bond oxidation, the free radicals are added to C = C bonds, and single electron oxidation and C (sp2)-H functionalization cascade reaction are carried out. Compared with an existing method, the preparation method has the outstanding advantages that the raw materials are cheap and easy to obtain, the reaction substrate is wide in application range, the target product yield is high, and the atom economy of the reaction is good.

The application belongs to the field of organic synthesis, and discloses a method for preparing chiral 2-(1,3-diarylallyl)malonate by using a Pd / phosphine oxygen bidentate phosphine phenol ligand catalysis, which comprises the following steps: under a protective atmosphere, mixing P, O-bidentate phosphine phenol ligand, a palladium catalyst, N, O-bis(trimethylsilyl)acetamide, a malonate nucleophilic reagent and an allyl acetate electrophilic reagent in dichloromethane, and reacting to obtain chiral 2-(1,3-diarylallyl)malonate product. The system has the advantages of high enantioselectivity, high catalytic efficiency, wide substrate application range and mild conditions.

This application relates to a lithium secondary battery electrolyte solution, a secondary battery, and an electrical device. The lithium secondary battery electrolyte solution includes an organic solvent and a first additive, a second additive, and an electrolyte salt that are dissolved in the organic solvent. The organic solvent includes a carboxylate solvent. A mass percent W1 of the carboxylate solvent in the organic solvent is 20% to 80%. The first additive includes one or more of monofluorophosphate, difluorophosphate, tetrafluoroborate, fluorosulfonate, oxalate borate, malonate borate, oxalate phosphate, or malonate phosphate. The second additive includes one or more of vinylene carbonate or a derivative thereof, or ethylene carbonate or a derivative thereof. The mass percent of the first additive and the mass percent of the second additive in the electrolyte solution are W2 or W3 respectively, satisfying: 0.035 ≤ (W2 + W3) / W1 ≤ 0.15. The electrolyte solution hereof makes the secondary battery superior in fast-charge performance, cycle performance, and storage performance.

The application relates to a low-temperature calcined ytterbium oxide powder and a preparation method thereof, and belongs to the technical field of metal powder processing. The preparation method comprises the following steps: reacting ytterbium carbonate with malonic acid in an aqueous solution to generate a ytterbium malonate precursor; dispersing the ytterbium malonate precursor in a buffer solution, adding a dopamine salt for polymerization coating, and forming a polydopamine coating layer on the surface of the particles; and calcining the coated compound at 500-750 DEG C to obtain the ytterbium oxide powder. The ytterbium malonate is used to replace the traditional ytterbium carbonate precursor, so that the thermal decomposition temperature can be effectively reduced; the carbon coating layer formed by carbonization of the polydopamine plays a particle spacing protection role in the calcination process, effectively inhibits excessive grain growth and hard agglomeration, and high-dispersity and high-purity ytterbium oxide powder can be obtained at a low temperature. The method has low raw material cost, simple and controllable process, is green and environment-friendly, and is suitable for large-scale industrial production.

This invention relates to the field of chemical synthesis, specifically to a malonate dithioester compound, its preparation method, and its uses. The structural formula of the malonate dithioester derivative of this invention is shown in Formula I. The malonate dithioester compound of this invention is more stable than malonyl chloride and has the advantage of higher reactivity than ordinary malonate ester derivatives, and can be used as an excellent intermediate for the synthesis of pyrido[1,2-α]pyrimidinone mesoionic compounds.

The present invention relates to the use of malonic monoamides and malonamide esters of formula (I) wherein the variables are as defined in the claims and the description for controlling unwanted vegetation, to a method for combating unwanted vegetation by using such compounds, to compositions comprising such compounds and to certain malonic acid monoamides and malonamide esters of formula (I). # imgabs0 #

The present disclosure provides methods for utilizing genetically modified microbes to co-produce 3-hydroxypropionic acid (3-HP) and acetyl-CoA, and derivatives thereof from malonate semialdehyde as a common single intermediate. The disclosure further provides modified microbe that co-produce the 3-HP and acetyl-CoA derivatives from malonate semialdehyde.

The present application relates to phenylethyl malonic acid diethyl ester heating technical field, specifically, it is a kind of phenylethyl malonic acid diethyl ester reaction heating device capable of uniform heating.It includes heating tank, feeding opening, discharge port and heater, heating tank is fixedly provided with sleeve inside, the sleeve is used to separate the inner wall of heating tank and sleeve into liquid storage cavity and shunt cavity, liquid storage cavity is located above shunt cavity, auxiliary liquid mixing stirring mechanism is arranged in the inner ring of sleeve, reciprocating mechanism is arranged at the top end of sleeve inside and the end of stirring mechanism.Liquid inside the sleeve is guided into the liquid storage cavity, then steam in the heater flows outward through shunt ring and steam pipe, the flowing steam can continuously conduct heat to the shunt ring, the shunt ring conducts heat to the sprayed liquid, and the sprayed liquid is divided into two streams under the action of shunt ring, so that the contact area of liquid and shunt ring is increased, thereby improving the efficiency of heat transfer and enhancing the uniformity of heat conduction.

The invention discloses an organic-inorganic hybrid malonate polar crystal material as well as a preparation method and application thereof, and belongs to the technical field of optical crystal materials. The chemical formula of the organic and inorganic hybrid malonate polar crystal material is RbLi (C3H2O4). H2O. The invention further discloses a preparation method of the organic and inorganic hybrid malonate polar crystal material. The invention also discloses a preparation method and application of the organic-inorganic hybrid malonate polar crystal material. According to the crystal material, flexible malonic acid radical anions are used as polar functional elements, the malonic acid radical is effectively induced to generate moderate structural distortion by utilizing a synergistic cation regulation strategy of Rb < + > and Li < + >, so that the crystal is stably crystallized in a polar space group, and meanwhile, the crystal material shows excellent nonlinear optical performance and is wide in application prospect.

Disclosed in the present invention is a process method for preparing fluopyram. The process method comprises the following steps: in the presence of a solvent 1, the compound potassium dimethyl 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]malonate reacting with a compound 1-D in a reaction vessel to obtain an intermediate compound, then distilling, and recovering the solvent 1, wherein the intermediate compound does not need to be purified; then adding water, a base, and a solvent 2 to the reaction vessel for reaction; after the reaction is finished, adjusting the pH, and continuing reaction; and after the reaction is finished, performing work-up to obtain the product fluopyram. The solvent 1 is selected from acetate solvents having a boiling point ranging from 40ºC to 110ºC at room temperature and atmospheric pressure. The process method of the present invention is simple, has high overall yield, and low cost, the quality of the product is stable and meets standards, and fluopyram is prepared in one pot, thereby facilitating reduction of the number of production devices, reducing investment, reducing costs, and increasing efficiency, and facilitating large-scale commercial production.

To provide a crystal of 2 - (4-acetylbenzyl) - 3 - ((4-fluorophenyl) amino) - 577 - trimethyl-7, 8-dihydro-pyrazolo-imidazo [1, 2-a] 2H [4, 3-e] pyrimidin-4 (5H) - one.SOLUTION: Provided is a crystal of an acid addition salt form selected from, for example, succinate form, citrate form, adipate form, tartrate form (e.g., L-tartrate form), malate form, gluconate form (e.g., D-gluconate form), maleate form, fumarate form, aspartate form (e.g., L-aspartate form), hippurate form, sebacate form, glycolate form, galactarate form, benzoate form, pamoate form, oxalate form and malonate form.SELECTED DRAWING: None

The invention discloses a synthesis method of 6-pentyl-2H-pyran-2-ketone, which comprises the following steps: step 1, reacting n-hexanoic acid or n-hexanoyl chloride with a malonate compound to obtain a compound a; step 2, carrying out carbonyl ketal protection reaction on the compound a to obtain a compound b; 3, the compound b is subjected to a reduction reaction, and a compound c is obtained; 4, the compound c is subjected to an oxidation reaction, and a compound d is obtained; 5, the compound d is subjected to a Wittig reaction, and a compound e is obtained; step 6, hydrolyzing the compound e, and removing a protecting group to obtain a compound f; and step 7, carrying out cyclization on the compound f, so as to obtain the 6-amyl-2H-pyran-2-one. According to the method, n-hexanoic acid (or n-hexanoyl chloride) serves as a starting raw material, 6PP is prepared through decarboxylation, ketal protection, reduction, oxidation, wittig reaction, hydrolysis deprotection and cyclization, the raw materials are cheap and easy to obtain, reaction conditions are mild, and the method is environmentally friendly and suitable for industrial production.

The present invention belongs to the field of pharmaceutical synthesis, and specifically relates to a method for synthesizing 3-(6-methoxy-2-pyridine)-propionic acid. The method comprises the following steps: 6-methoxy-2-pyridinemethanol reacts with p-toluenesulfonyl chloride to obtain a p-toluenesulfonate intermediate, and then the p-toluenesulfonate intermediate reacts with a bromide salt to obtain 2-(bromomethyl)-6-methoxypyridine; 2-(bromomethyl)-6-methoxypyridine reacts with diethyl malonate under the action of a base to generate 3-(6-methoxy-2-pyridylmethyl)-diethyl malonate, and 3-(6-methoxy-2-pyridylmethyl)-diethyl malonate is hydrolyzed and decarboxylated to obtain 3-(6-methoxy-2-pyridine)-propionic acid. The invention uses 6-methoxy-2-pyridinemethanol as a starting material, and performs hydrolysis and decarboxylation after three-step substitution reaction to obtain 3-(6-methoxy-2-pyridine)-propionic acid. The method has the advantages of fewer reaction steps, economical and cheap reagents, mild reaction conditions and high product purity, and is suitable for industrial production.

The invention discloses a kind of ethyl benzoate and its preparation method, belong to the field of fine chemical preparation. The preparation method of ethyl benzoate is, in the first step, acrolein and ethyl malonate are subjected to Kneuwengel condensation reaction to generate enester under triethylenediamine catalyst; In the second step, the diene ester and acrolein generated by the first step undergo Diels-Alder reaction to obtain cyclohexene carboxylate substituted with aldehyde group; In the third step, the cyclohexene carboxylate substituted with aldehyde group is subjected to decarbonylation and dehydrogenation reaction to generate ethyl benzoate under metal catalyst. The reaction conditions of the present invention are simple, the catalyst is simple and easy to obtain, and the cost is low. It is a method for synthesizing spices and flavors through a biomass route with great industrialization prospects.

The invention discloses a method for purifying lithium diallyl malonate borate, which comprises the following steps of: 1, adding a first mixed solvent which comprises a high-polarity organic solvent and a low-polarity organic solvent in a mass ratio of (1: 1)-(1: 5) into lithium diallyl malonate borate crude salt, heating, stirring, dissolving and filtering to remove organic impurity filtrate; 2, the filter cake is subjected to vacuum drying and then ground into fine powder, a second mixed solvent is added, cooling and stirring are conducted, the second mixed solvent comprises a high-polarity organic solvent and a low-polarity organic solvent, and the mass ratio of the high-polarity organic solvent to the low-polarity organic solvent is 9: 1-3: 1; filtering while cold to remove insoluble impurity salt; and 3, concentrating the filtrate into particles, grinding the particles into fine powder, and transferring the fine powder to a vacuum drying oven for drying to obtain a lithium bis (malonate) borate finished product. The method has the advantages that the product purity is high, the metal ion content is low, the operation steps are simple, the purification cost is low, and the use requirements of the electrolyte additive are met.

A lithium secondary battery electrolyte solution includes an organic solvent and a first additive, a second additive, and an electrolyte salt that are dissolved in the organic solvent. The organic solvent includes a carboxylate solvent. A mass percent W1 of the carboxylate solvent in the organic solvent is 20% to 80%. The first additive includes one or more of monofluorophosphate, difluorophosphate, tetrafluoroborate, fluorosulfonate, oxalate borate, malonate borate, oxalate phosphate, or malonate phosphate. The second additive includes one or more of vinylene carbonate or a derivative thereof, or ethylene carbonate or a derivative thereof. The mass percent of the first additive and the mass percent of the second additive in the electrolyte solution are W2 or W3 respectively, satisfying: 0.035≤(W2+W3) / W1≤0.15.

The present invention discloses a method for preparing an indole-3-ylalkyl malonate compound. The method uses economical, cheap and readily available reaction raw materials, and is carried out under mild electrochemical conditions by reacting C (sp) with three components. 3 )–H / C(sp 2 )–H functionalization reaction, one-step construction to obtain indole-3-alkyl malonate compounds. This method is through C(sp 3 )‑H / C(sp 2 )-H functionalization regioselective pathway, with H2 as the only theoretical byproduct. Mechanistic studies suggest that the reaction proceeds via C(sp 3 )-H bond oxidation to generate alkyl radicals, radical addition to C=C bond, single electron oxidation and C(sp 2 Compared with existing methods, the preparation method of the present invention has the advantages of cheap and readily available raw materials, a wide range of reaction substrates, high yield of target products and good atom economy of the reaction.

The application discloses an asymmetric catalytic hydrogenation method of indolocyclopentenyl malonate and application thereof. The method comprises the following steps: in the presence of hydrogen atmosphere, a chiral Ir-SpiroPAP catalyst, a base and a solvent, performing asymmetric catalytic hydrogenation on indolocyclopentenyl malonate to obtain indolocyclopentenyl malonate. The indolocyclopentenyl malonate containing one tertiary carbon chiral center prepared by the method can be used as a key chiral raw material for asymmetric synthesis of a chiral drug Velsipity (Etrasimod). The method has higher enantioselectivity, lower catalyst consumption and a wide substrate application range.

Polymorphic forms of crystalline epinephrine malonate salt, including Form A, Form B, and Form C of crystalline epinephrine malonate salt. Also described are pharmaceutical compositions comprising one or more the polymorphic forms and methods for treating a patient comprising administering a pharmaceutical composition of one of the polymorphic forms of crystalline epinephrine malonate.

Disclosed are chromane compounds, analogs thereof, and methods of their synthesis and use. The compounds may be synthesized by methods involving reductive annulations of arylidene malonates with unsaturated electrophiles using photoredox / Lewis acid cooperative catalysis. The compounds may be formulated in a pharmaceutical composition for treating one of the aforementioned diseases or disorders.

The present disclosure relates to methods, cells, and compositions useful for producing malonate.

This invention discloses a controlled-release nitrogen fertilizer containing organic acid salt signaling substances. From the inside out, it comprises urea particles, a cross-linked material-trace element mixture, molten urea, and a bio-based polyurethane coating material. The cross-linked material-trace element mixture is a porous cross-linked material loaded with trace elements. The porous cross-linked material is obtained by cross-linking alginic acid and organic acid salts through a cross-linking agent. The organic acid salts are selected from at least one of sodium citrate, sodium fumarate, sodium maleate, sodium malonate, and sodium succinate. The trace elements are selected from at least one of zinc, cobalt, molybdenum, and iron. This invention, through alginic acid-organic acid salt cross-linking, precise loading of trace elements, and multi-layer coating technology, produces a novel controlled-release fertilizer that combines pH responsiveness, environmental resistance, and high nutrient utilization. Nutrient release can be dynamically controlled according to soil pH and crop needs, reducing nutrient loss and environmental pollution, meeting the needs of green agriculture development, and providing an innovative solution for improving fertilizer utilization and crop yield.

The invention relates to a method for constructing a spectrum-effect relationship of dried orange peel from different producing areas based on electrochemical fingerprints in combination with antioxidant activity. The method comprises the following steps: establishing electrochemical fingerprints of dried orange peel from different producing areas under the conditions that the temperature is 35 DEG C, the concentration of sulfuric acid is 1mol / L, the concentration of ceric ammonium sulfate is 0.005 mol / L, the concentration of malonic acid is 0.45 mol / L and the concentration of sodium bromate is 0.3 mol / L; an ABTS free radical scavenging rate method with high sensitivity and stability is selected for antioxidant activity evaluation. Meanwhile, a rapid and accurate spectrum-activity relationship method is established by analyzing the spectrum-activity relationship between the electrochemical fingerprints of the dried orange peel from different producing areas and the semi-inhibitory concentration of the ABTS free radical scavenging rate in combination with Pearson correlation. The method has certain scientific value and wide application value.

The invention discloses a polyether malonate fullerene derivative and a preparation method and application thereof, and belongs to the technical field of photovoltaic materials.The preparation method comprises the steps that firstly, a polyether malonate derivative is prepared, then the obtained polyether malonate derivative reacts with DBU, I2 and C60 under the water-free and oxygen-free conditions to obtain the polyether malonate fullerene derivative, and finally the polyether malonate fullerene derivative is obtained. The synthesis method is simple, application is convenient, operability is high, reaction raw materials are low in price and easy to obtain, the process for preparing a perovskite solar cell by using the polyether malonate fullerene derivative prepared through the method as an electron transport material is green and environmentally friendly, and the corresponding perovskite solar cell has the advantages of being high in device efficiency and stability.

The application discloses plant oil-containing insulating oil and a preparation method and application thereof, and belongs to the technical field of lubricating oil, and is used for solving the problems that plant oil-type insulating oil is prone to solidification at low temperature, and antioxidation stability and flame retardation need to be further improved in the prior art, wherein the preparation method of the plant oil-containing insulating oil comprises the following steps: uniformly mixing dimethyl 2-(4-aminophenyl)malonate and 4-(1-hydroxyethyl)-2,6-dimethoxyphenol in an inert gas atmosphere, adding dibutyl tin dilaurate, stirring, heating, and reacting to obtain modified steric phenol; mixing N,N-dimethylformamide, the modified steric phenol and di-tert-butyl chloromethyl phosphate, adding triethylamine, heating to reflux, stopping the reaction, washing, and drying to obtain a modified antioxidant; the plant oil-containing insulating oil prepared by the application has environmental protection, antioxidation and certain flame retardation, and is not prone to solidification at low temperature, these characteristics expand the application range of the insulating oil, and meet more strict application requirements.

本发明属于化学传感技术领域，具体涉及一种基于逻辑门检测 HeLa 细胞内阴离子的 NBD 锌配合物双模式光学探针及其制备方法和应用。所述传探针分子式为Zn(NBD‑BPHA)I2，其合成方法简单，实施可行性高，成本低廉，灵敏度、选择性、稳定性高，可同时检测丙二酸根、草酸根和焦磷酸根阴离子，为丙二酸根、草酸根和焦磷酸根阴离子检测领域的应用提供了一种新方法。

The invention relates to a method for recovering dipropyl malonic acid monoester as shown in a chemical structural formula I. The method comprises the following steps: carrying out dipropylation on 1-chloropropane and malonic acid diester in DMF (Dimethyl Formamide) under the action of potassium carbonate or sodium carbonate and quaternary ammonium salt to obtain dipropyl malonic acid diester; in the process of preparing dipropyl malonate, an alcohol solvent is added into a filter cake inorganic salt [residual dipropyl malonate monoester (III)], and dipropyl malonate monoester # imgabs0 # shown in a formula I is obtained through pulping, acidification, crystallization, filtration and low-temperature vacuum drying, wherein M is selected from K or Na; r1 is selected from straight chain alkyl with 1 to 5 carbon atoms or branched chain alkyl with 3 to 5 carbon atoms; the alcohol solvent is selected from methanol, ethanol, C3-C6 straight chain or C3-C6 branched chain monohydric alcohol, ethylene glycol, C3-C5 straight chain dihydric alcohol or C4-C5 branched chain dihydric alcohol; h < + > is selected from hydrochloric acid, phosphoric acid or sulfuric acid.

The utility model discloses a rectifying still for producing diethyl phenylethyl malonate, which is characterized in that a plurality of layers of pore plates are arranged in a still body through an annular support plate, a main shaft penetrates through guide sleeves of the pore plates, and after entering the still body, a diethyl phenylethyl malonate crude product reacts with rising steam, so that gas phase and liquid phase separation is realized; a gas phase is discharged from a gas phase outlet in the top, a liquid phase flows to the bottom of the kettle body, and in the process, when liquid phase stirring and heating in the kettle body are carried out through a stirring paddle at the bottom, the heat exchange effect is improved, so that the gas phase separation effect during boiling is improved, contact between steam and liquid is realized through a pore plate, and the gas-liquid separation effect is improved; a stirring rod is mounted above each layer of pore plate through a main shaft, so that the contact area of steam and the crude product of the diethyl phenylethylmalonate is greatly increased through stirring of the stirring rods, the gas-phase separation effect of the diethyl phenylethylmalonate is further improved, the rectification frequency is reduced, and the efficiency is improved.