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1723results about How to "Inhibit production" patented technology
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Methods of treating HIV infected subjects
InactiveUS6905680B2Expanding population of cellIncrease the number ofVirusesPeptide/protein ingredientsAccessory moleculeExogenous growth
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR) / CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.
Owner:GENETICS INST INC +2
System to control content and prohibit certain interactive attempts by a person using a personal computer
InactiveUS6065056AReduce usageAvoid spreadingDigital data information retrievalMultiple digital computer combinationsPasswordWord search
A computer, terminal and a method for blocking the use and creating of vulgar and pornographic material in a responsive and interactive matter that comprehensively monitors computer operations for creation or transmission of vulgar and pornographic material. Data created by the keyboard, data passing through the clipboard, data selected by the mouse pointer, and data passing through the Internet interface are monitored for content and further operation of the computer terminal is blocked. The computer terminal may only be unblocked by a supervisory intervention, such as by entering of a password, or by restarting or resetting the terminal. Key word searches, such as those in Internet search engines, are also monitored, but the terminal adapts to monitor not only for words of a profane and vulgar nature, but also for words that are behaviorally tested to produce lists containing vulgar and profane items, e.g., Internet sites. The computer terminal and method can be modified to block other forms of communication or computer operation, such as blocking transmission of secret business data, blocking execution or opening of certain programs or files, and the like.
Owner:TW SECURITY CORP
Tunable catalyst gas phase hydrogenation of carboxylic acids
InactiveUS20100121114A1High selectivityExcessive loss of activityOrganic compound preparationHeterogenous catalyst chemical elementsPlatinumAcetic acid
A process for selective formation of ethanol from acetic acid includes contacting a feed stream containing acetic acid and hydrogen at an elevated temperature with catalyst comprising platinum and tin on a high surface area silica promoted with calcium metasilicate. Selectivities to ethanol of over 85% are achieved at 280° C. with catalyst life in the hundreds of hours.
Owner:CELANESE INT CORP
Permeable cement and sand control methods utilizing permeable cement in subterranean well bores
InactiveUS20040261993A1Inhibit productionMinimize potentialFluid removalFlushingMaterials scienceCement
This invention relates to improved methods for completing wells in unconsolidated subterranean zones. More specifically, the present invention relates to cement compositions useful in subterranean applications, and more particularly, to permeable cement compositions and methods for forming consolidated permeable cement masses in well bores to prevent sand influx into the well bores with produced fluids. In one embodiment, the permeable cement compositions of the present invention comprise a hydraulic cement, water, and a degradable material capable of undergoing an irreversible degradation downhole.
Owner:HALLIBURTON ENERGY SERVICES INC
Integral joining
InactiveUS7160405B2Optimum introduction of loadHarmful stress concentrationLaminationLamination apparatusMaterials science
Owner:WOODWELDING
Material storage and dispensing packages and methods
InactiveUS20090212071A1Solve the lack of spaceInhibit productionPower operated devicesShock-sensitive articlesEngineeringParticle generation
Packages and methods for storage and dispensing of materials, e.g., high purity liquid reagents and chemical mechanical polishing compositions used in the manufacture of microelectronic device products, including containment structures and methods adapted for pressure-dispensing of high-purity liquids. Liner packaging of liquid or liquid-containing media is described, in which zero or near-zero head space conformations are employed to minimize adverse effects of particle generation, formation of bubbles and degradation of contained material.
Owner:ADVANCED TECH MATERIALS INC
Integral joining
InactiveUS20050126680A1Optimum introduction of loadHarmful stress concentrationLaminationLamination apparatusMaterials science
Owner:WOODWELDING
Thermoplastic dicyclopentadiene-base open-ring polymers, hydrogenated derivatives thereof, and processes for the preparation of both
InactiveUS6511756B1Improve efficiencyGood moldabilityPlastic/resin/waxes insulatorsSynthetic resin layered productsThermoplasticDouble bond
A thermoplastic dicyclopentadiene ring-opening polymer obtained by ring-opening polymerization of a monomer component containing a dicyclopentadiene monomer, characterized in that polycyclic rings which are repeating units of the polymer are bonded in cis-position relative to the carbon-carbon double bond of the main chain of the polymer in 50 mol % or more of the repeating units based on the total repeating units and the content of a low-molecular weight component of 2,000 or less in molecular weight is 10% by weight or less based on the total polymer components, and a hydrogenation product obtained by hydrogenating the carbon-carbon unsaturated bond of the thermoplastic dicyclopentadiene ring-opening polymer.
Owner:ZEON CORP
Heterocyclic compounds as inhibitors of beta-lactamases
This invention discloses and claims methods for inhibiting bacterial β-lactamases and treating bacterial infections by inhibiting bacterial β-lactamases in man or an animal comprising administering a therapeutically effective amount to said man or said animal of a compound, or pharmaceutically acceptable salt thereof, of formula (I) either alone or in combination with a β-lactamine antibiotic wherein said combination can be administered separately, together or spaced out over time. Pharmaceutical compositions comprising a compound of formula (I), or a combination of a compound of formula (I) and a therapeutically effective amount of a β-lactamine antibiotic, and a pharmaceutically acceptable carrier are also disclosed and claimed.
Owner:FOREST LAB HLDG LTD
Fused heterocyclic compounds
ActiveUS20050250770A1Inhibit productionInhibit formationSenses disorderNervous disorderDiseaseStereochemistry
This invention provides fused heterocyclic compounds, pharmaceutical compositions of, the compounds, and methods of using the compounds for the treatment of, inter alia, IL-12 related disease and disorders.
Owner:MADRIGAL PHARMA INC
Library of compounds comprising pyrrolobenzodiazepine moieties
InactiveUS7704924B2Easily brokenPrevent premature cleavageAntibacterial agentsOrganic active ingredientsNitrogenDouble bond
A compound of formula (IV): O is a solid support; L is a linking group or a single bond; X′ is selected from CO, NH, S, or O; A is O, S, NH, or a single bond; R2 and R3 are independently selected from: H, R, OH, OR, ═O, ═CH—R, ═CH2, CH2—CO2R, CH2—CO2H, CH2—SO2R, O—SO2R, CO2R, COR, CN and there is optionally a double bond between C1 and C2 or C2 and C3; R6, R7, and R9 are independently selected from H, R, OH, OR, halo, nitro, amino, Me3Sn; R11 is either H or R; Q is S, O or NH; R10 is a nitrogen protecting group; and Y is a divalent group such that HY═R, and other related compounds and collections of compounds.
Owner:MEDIMMUNE LTD
Pump systems and methods
InactiveUS6543543B2Increase pressureInhibit productionPositive displacement pump componentsConstructionsParticulatesReciprocating motion
A pumping system comprises a pump barrel that is adapted to be placed into a well casing. A plunger is reciprocatably positioned within the pump barrel and has an open top end, a bottom end, and a traveling valve at the bottom end. A connector is coupled to the plunger below the top end. A rod is coupled to the connector and is translatable to reciprocate the plunger within the pump barrel using an upstroke and a downstroke. Further, the top end of the plunger is adapted to direct particulate into the plunger and away from the pump barrel upon each upstroke.
Owner:MUTH PUMP
Electrically heated water pipe smoking device
A water pipe including a bowl for placing therein a smoking substance, a tube that fluidly connects the bowl to a base member, at least one hose connection port, in fluid communication with the base member, for connecting with at least one flexible hose, an electric heating element disposed in the bowl for heating the smoking substance, the electric heating element being shaped as an inner periphery of the bowl, and a controller in electrical communication with the electric heating element, the controller controlling electrical power to the electric heating element for heating the smoking substance to a temperature that vaporizes volatile aromatic components of the smoking substance without substantially causing combustion of the smoking substance.
Owner:KANNEL MANAGEMENT
Methods and compositions for the inhibition of transplant rejection
InactiveUS20120177645A1Inhibit and reduce transplant rejection of insulin-producingInhibiting and reducing chronic transplant rejectionNervous disorderAntibody mimetics/scaffoldsTransplant rejectionT cell
Methods for modulating immune responses in a subject are provided. A preferred embodiment provides methods and compositions for reducing or inhibiting transplant rejection in a subject, preferably a human subject. Transplant rejection can be inhibited or reduced in a subject by administering an effective amount of B7-H4 polypeptide, fragments or fusions thereof to inhibit or reduce the biological activity of an immune cell or to reduce the amounts of proinflammatory molecules at a site of transplant. Th1, Th17 and Th22 cells are exemplary T cells that can be targeted for inhibition by B7-H4 polypeptides, fusion proteins or fragments thereof to inhibit or reduce inflammation.
Owner:MEDIMMUNE LLC
Polypeptides related to natriuretic peptides and methods of their identification and use
InactiveUS7341838B2Prevent degradationThe result is accurateCompound screeningApoptosis detectionTissue sampleEvent triggered
The present invention relates to the identification and use of polypeptides that bind to antibodies directed to a desired polypeptide of interest. Using natriuretic peptides and their precursors, and in particular BNP, as an example, the present invention describes a number of natriuretic peptides fragments produced in biological samples, most preferably blood-derived samples, that bind to antibodies directed to BNP. Because production of such fragments is an ongoing process that may be a function of, inter alia, the elapsed time between onset of an event triggering natriuretic peptide release into the tissues and the time the sample is obtained or analyzed; the elapsed time between sample acquisition and the time the sample is analyzed; the type of tissue sample at issue; the storage conditions; the quantity of proteolytic enzymes present; etc., such fragments may be used when both designing an assay for one or more natriuretic peptides, and when performing such an assay, in order to provide an accurate prognostic or diagnostic result.
Owner:VERMILLION INC +1
Optical integrator, illumination optical device, exposure device, and exposure method
ActiveUS20070132977A1Easily avoidedInhibit productionMirrorsPhotomechanical apparatusLight beamEngineering
An optical integrator of a wavefront dividing type permits an arbitrary distance to be set between an entrance surface and an exit surface, without production of aberration and without reduction in reflectance on reflecting films. The optical integrator has a plurality of first focusing elements (first concave reflector elements 18a) arranged in parallel, a plurality of second focusing elements (second concave reflector elements 20a) arranged in parallel so as to correspond to the first focusing elements, and a relay optical system (19) disposed in an optical path between the first focusing elements and the second focusing elements. The relay optical system refocuses a light beam focused via one of the first focusing elements, on or near a corresponding second focusing element so as to establish an imaging relation of one-to-one correspondence between one of the first focusing elements and one of the second focusing elements.
Owner:NIKON CORP
Blocking/inhibiting operation in an arc fault detection system
InactiveUS6477021B1Reliably detectsImprove reliabilityPower network operation systems integrationEmergency protection for supplying operative powerWave shapeElectrical and Electronics engineering
A system for determining whether arcing is present in an electrical circuit includes a sensor for monitoring a current waveform in the electrical circuit, and an arc fault detection circuit which determines whether an arc fault is present in response to the sensor. The arc fault detection circuit includes a controller which produces a trip signal in response to a determination that an arcing fault is present in the electrical circuit, and an inhibit / blocking function for preventing the production of the trip signal under one or more predetermined conditions.
Owner:SQUARE D CO
Pump systems and methods
InactiveUS6250392B1Inhibit sand productionIncrease pressureConstructionsPositive displacement pump componentsParticulatesReciprocating motion
A pumping system comprises a pump barrel that is adapted to be placed into a well casing. A plunger is reciprocatably positioned within the pump barrel and has an open top end, a bottom end, and a traveling valve at the bottom end. A connector is coupled to the plunger below the top end. A rod is coupled to the connector and is translatable to reciprocate the plunger within the pump barrel using an upstroke and a downstroke. Further, the top end of the plunger is adapted to direct particulate into the plunger and away from the pump barrel upon each upstroke.
Owner:MUTH PUMP
Pump systems and methods
InactiveUS20020066572A1Increase pressureInhibit productionPositive displacement pump componentsConstructionsParticulatesReciprocating motion
A pumping system comprises a pump barrel that is adapted to be placed into a well casing. A plunger is reciprocatably positioned within the pump barrel and has an open top end, a bottom end, and a traveling valve at the bottom end. A connector is coupled to the plunger below the top end. A rod is coupled to the connector and is translatable to reciprocate the plunger within the pump barrel using an upstroke and a downstroke. Further, the top end of the plunger is adapted to direct particulate into the plunger and away from the pump barrel upon each upstroke.
Owner:MUTH PUMP
Compounds to treat Alzheimer's disease
The present invention is substituted amines of formula (XV) useful in treating Alzheimer's disease and other similar diseases.
Owner:ELAN PHARM INC
Method for screening compounds inhibiting signal transduction through inflammatory cytokines
InactiveUS6989244B1Avoid low activityHigh activityCompound screeningApoptosis detectionCytokineProinflammatory cytokine
The present invention relates to methods of screening for compounds that inhibit signal transduction by inflammatory cytokines. The methods include providing a sample that contains a TAK1 and a TAB1; contacting the sample with a compound; detecting binding between the TAK1 and the TAB1; and selecting the compound if binding between the TAK1 and TAB1 is inhibited in the sample compared to a control.
Owner:CHUGAI PHARMA CO LTD
Method of separation and recovery of elements from radioactive liquid wastes
InactiveUS6843921B2Efficient elutionImprove efficiencyOther chemical processesSolid sorbent liquid separationRare-earth elementElution
A method of separation and recovery of elements from radioactive liquid wastes, includes a step of bringing into contact a high-level radioactive liquid waste containing separation target elements including Americium, Curium, Zirconium, Molybdenum, Palladium and rare earth elements with solid absorbent containing organophosphorus compounds so that the separation target elements are absorbed in the solid absorbent, a step of bringing into contact the solid absorbent with an acidic solution containing diethylenetriaminepentaacetic acid so that Americium, Curium, Zirconium, Molybdenum, Palladium and heavy rare earth elements are eluted from the solid absorbent, and a step of bringing into contact the solid absorbent underwent the first elution step with water or dilute nitric acid so that light rare earth elements are eluted from the solid absorbent. With the method, elements, which include Americium, Curium, Zirconium, Molybdenum, Palladium and rare earth elements, are efficiently and economically separated and recovered from the radioactive liquid waste.
Owner:JAPAN ATOMIC ENERGY AGENCY INDEPENDANT ADMINISTRATIVE CORP +1
Reducing concentration of organic materials with substituted cyclodextrin compound in polyester packaging materials
InactiveUS6709746B2Inhibit productionImprove barrier propertiesNon-fibrous pulp additionWrappersScavengerCyclodextrin
Volatile organic compound or other materials are produced in the thermoplastic manufacture of thermoplastic polyester beverage containers. Such materials can be eluted into beverages such as carbonated beverages, sparkling or still water from the polyester. Such thermoplastic polyester resins can be manufactured with a substituted cyclodextrin material that can prevent the formation of, or react with, and absorb volatile by-products during the formation of thermoplastic preforms or containers from the thermoplastic pellet or chip. Further, as the preform is blown into a polyester container, the active materials of the invention prevent the generation of additional undesirable volatile materials. Lastly, the scavenger material can act as a barrier that prevents transport of materials from the exterior of the container into the container contents.
Owner:ARTEVA NORTH AMERICA SARL +1
Stirring coffee press
InactiveUS7040218B1Easily and efficiently manufactured and marketedLow priceBeverage vesselsFree rotationEngineering
A stirring coffee press for brewing beverage grounds, such coffee or tea, while simultaneously compressing and agitating the grounds in a single container. The stirring coffee press includes a container with a fitted lid, a plunger assembly slidably and rotatably received within the container and being attached to a hollow shaft which extends out through an opening in the lid, and a blade assembly attached to a shaft that extends and exits through the hollow shaft of the plunger assembly. The hollow shaft of the plunger assembly has a handle attached to the end of the hollow shaft, wherein the plunger handle is adapted to be received and retained into the aperture in the lid, thereby preventing the plunger assembly from rotating. The blade assembly shaft has a knob attached to its open end allowing the blade assembly to be freely rotated.
Owner:BIOLCHINI JR ROBERT F
Process for producing fibrillated fibers
ActiveUS7566014B2Inhibit productionIncreased fiber lengthFilament/thread formingGrain treatmentsFiberShear rate
A process for making fibrillated fibers includes preparing a fluid suspension of fibers, low shear refining the fibers at a first shear rate to create fibrillated fibers having a reduced CSF, and subsequently higher shear refining the fibers at a second shear rate, higher than the first shear rate, to increase the degree of fibrillation of the fibers. The refining at the first shear rate may be with a rotor at a first maximum shear rate and the refining at the second shear rate may be with a rotor at a second maximum shear rate, higher than the first maximum shear rate. The process may further include pre-treating the fibers by high shear refining with impact to stress the fibers prior to low shear refining.
Owner:KX TECH LLC (DW US)
Selective androgen receptor modulators and methods of use thereof
InactiveUS20060241180A1Shorten the progressPrevent relapseBiocideGroup 4/14 element organic compoundsDiseaseSelective androgen receptor modulator
This invention provides a class of androgen receptor targeting agents (ARTA). The compounds are selective androgen receptor modulators (SARM) useful for, inter-alia, suppressing spermatogenesis, treating a subject having a hormone related condition, treating a subject suffering from prostate cancer, delaying the progression of prostate cancer, preventing the recurrence of prostate cancer, and treating the recurrence of prostate cancer.
Owner:UNIV OF TENNESSEE RES FOUND
Novel azole compound
InactiveUS20060194850A1Improve liver functionInhibition of physiological activityBiocideNervous disorderDiseaseHydrogen atom
Azole compounds represented by formula I: wherein ring A is isoxazole and the like, R1 is a substituted or unsubstituted aryl group and the like, R2 is a hydrogen atom and the like, and R3 is a substituted or unsubstituted alkyl group and the like, and pharmaceutically acceptable salts thereof inhibit the physiological activity of lysophosphatidic acid (LPA), and are useful as for the prophylaxis or treatment of diseases in which inhibition of the physiological activity of LPA is useful for the prophylaxis or treatment thereof, such as diseases involving the LPA receptor.
Owner:AJINOMOTO CO INC
Plasma processing apparatus
InactiveUS20060236932A1Inhibit productionElectric discharge tubesSemiconductor/solid-state device manufacturingEngineeringVacuum chamber
The invention provides a plasma processing apparatus capable of preventing the production of particle and preventing the influence of particle on the sample. The plasma processing apparatus comprises a vacuum chamber; process gas introducing means for introducing process gas into the vacuum chamber; means, coupled to a first RF power supply, for applying RF energy to the process gas introduced into the vacuum chamber to turn the process gas into plasma; a sample mounting electrode for mounting a sample on an upper surface thereof and holding the sample in the vacuum chamber; evacuation means for evacuating the process gas in the vacuum chamber; and plasma confining means, provided on a peripheral side of the mounting electrode in the vacuum chamber, for inflecting flow of the process gas caused by the evacuation means on a downstream side of a sample mounting surface of the mounting electrode to prevent plasma from diffusing downstream of the sample mounting surface.
Owner:HITACHI HIGH-TECH CORP
Light-emitting-diode lamp
InactiveUS7585090B2Easy to assembleLow costCoupling device connectionsLighting support devicesElectricityIlluminance
A light-emitting-diode (LED) lamp includes a control circuit board having a control circuit and a plurality of insertion holes provided thereon; a plurality of LED units, each of which including a circuit board, a plurality of LEDs mounted on the circuit board, and terminals provided at an end of the circuit board for plugging into the insertion holes on the control circuit board to thereby electrically assemble the LED unit to the control circuit board; and a glass bulb or tube for receiving the assembled control circuit board and LED units to complete the LED lamp that can be mounted to a general lamp holder. When electricity is supplied to the LED lamp, the LEDs are driven by the control circuit to emit light for illumination. The number of LED units and of the LEDs may be adjusted according to desired illuminance.
Owner:UWIN TECH
Sand Control Screen Assembly and Method for Use of Same
A sand control screen assembly (40) is operably positionable within a wellbore (48). The sand control screen assembly (40) includes a base pipe (42) having at least one opening (60) and an internal flow path (44). A swellable material layer (46) is disposed exteriorly of the base pipe (42). A fluid collection subassembly (50) is disposed exteriorly of the swellable material layer (46). The fluid collection subassembly (50) is in fluid communication with the internal flow path (44). A filter medium (62) is operably associated with the sand control screen assembly (40) and is disposed in a fluid path between the exterior of the sand control screen assembly (40) and the internal flow path (44). In response to contact with an activating fluid, radial expansion of the swellable material layer (46) causes at least a portion of the fluid collection subassembly (50) to contact the wellbore (48).
Owner:HALLIBURTON ENERGY SERVICES INC
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