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441 results about "Streptococcus" patented technology

Streptococcus is a genus of gram-positive coccus (plural cocci) or spherical bacteria that belongs to the family Streptococcaceae, within the order Lactobacillales (lactic acid bacteria), in the phylum Firmicutes. Cell division in streptococci occurs along a single axis, so as they grow, they tend to form pairs or chains that may appear bent or twisted. (Contrast with that of staphylococci, which divide along multiple axes, thereby generating irregular, grape-like clusters of cells.)

Preparation method of tricholoma matsutake fermentation product with anti-wrinkle and firming effects as well as product and application of tricholoma matsutake fermentation product

The invention relates to a preparation method of a tricholoma matsutake fermentation product with anti-wrinkle and firming effects as well as a product and application of the tricholoma matsutake fermentation product. The preparation method comprises the following steps: mixing a composite plant extract, a carbon source, inorganic salt and water, then sterilizing to obtain a sterilized culture medium, inoculating a composite probiotic agent into the medium, and carrying out fermentation culture to obtain the tricholoma matsutake fermentation product with anti-wrinkle and firming effects. Centrifuging, filtering and sterilizing the culture product to obtain a tricholoma matsutake fermentation product; the bacterial strains in the compound probiotic agent comprise a combination of streptococcus thermophilus, a lactobacillus paracasei YK-L003 bacterial strain and a saccharomyces cerevisiae YK-S001 bacterial strain. According to the invention, specific strains are subjected to compounding and combined fermentation, and the fermentation product filtrate obtained after fermentation treatment of the three strains has an excellent skin conditioning effect, can effectively improve the skin state and resist and weaken wrinkles, and has an excellent effect when being applied to moisturizing and anti-wrinkle cosmetics.
Owner:GUANGZHOU YOUKE BIOTECHNOLOGY CO LTD

Preparation method of rice leavening with scalp care effect as well as product and application of rice leavening

The invention relates to a preparation method of a rice leavening with a scalp care effect and a product and application thereof, the preparation method comprises the following steps: mixing a rice raw material, a plant raw material, water, a magnesium salt, a sodium salt and Tween, sterilizing to obtain a fermentation medium, inoculating a compound microbial agent into the fermentation medium, and fermenting to obtain the rice leavening with the scalp care effect. After the fermentation liquid is finished, sterilizing and filtering to obtain a rice leavening; wherein the compound microbial agent comprises a first microbial strain and a second microbial strain; the strains in the first microbial strain comprise a combination of streptococcus thermophilus, bifidobacterium breve and a plant lactobacillus YK-L002 strain; and the second microbial strain comprises a trichosporon YK-S004 strain. According to the invention, specific strains are subjected to compounding and combined fermentation, and the fermentation product filtrate obtained after fermentation treatment of four bacteria has excellent hair care and nourishing effects, and can effectively condition the scalp micro-ecological environment and nourish the hair quality.
Owner:ZHENGZHOU JUNXI COSMETICS CO LTD

Probiotic composition for preventing and / or inhibiting oral pathogens as well as derivative product, preparation method and application thereof

The invention provides a probiotic composition for preventing and / or inhibiting oral pathogens as well as a derivative product, a preparation method and application of the probiotic composition, and belongs to the technical field of oral care. The probiotic composition comprises the following bacterial strains in parts by mass: 90 to 0.45 part of a lactobacillus rhamnosus bacterial strain A2114, 10 to 0.3 part of a plant lactobacillus bacterial strain A2124, 80 to 0.4 part of a pediococcus pentosaceus bacterial strain A2135, 250 to 0.25 part of a lactobacillus reuteri bacterial strain A21350, and 40 to 0.2 part of a plant lactobacillus bacterial strain A2109. The probiotic composition or the metabolite thereof can effectively inhibit oral pathogens such as streptococcus mutans, porphyromonas gingivalis, helicobacter pylori, escherichia coli and staphylococcus aureus. Therefore, the probiotic composition or the metabolite thereof shows a good application prospect in the aspects of preventing and relieving oral problems such as decayed teeth, periodontitis and ozostomia.
Owner:SICHUAN AISHENG LIFE TECHNOLOGY CO LTD +2

Probiotic granules capable of improving intestinal functions as well as preparation method and application of probiotic granules

The invention belongs to the technical field of probiotic particles, and particularly relates to probiotic particles for improving intestinal functions as well as a preparation method and application of the probiotic particles. The probiotic particles capable of improving the intestinal function comprise a probiotic core, a first embedding layer, a second embedding layer and a third embedding layer, the probiotic inner core is prepared from plant lactobacillus, bifidobacterium animalis, lactobacillus acidophilus, bifidobacterium longum, lactobacillus paracasei, lactobacillus rhamnosus, lactobacillus fermentum, lactobacillus helveticus, streptococcus thermophilus, plant lactobacillus, lactobacillus helveticus and lactobacillus rhamnosus. According to the present invention, the twelve probiotics are contained, and the latest three-layer embedding technology is adopted so as to enhance the storage property and the digestive tract tolerance, such that the product can maintain the beneficial bacterium activity for a long time without refrigeration, and the product is suitable for the crowd with the alteration of the intestinal flora.
Owner:JIANG TENG MEDICAL SCI & TECH CO LTD

Preparation method of white truffle fermentation product with anti-oxidation effect as well as product and application of white truffle fermentation product

The invention relates to a preparation method of a white truffle fermentation product with an anti-oxidation effect as well as a product and application of the white truffle fermentation product. The preparation method comprises the following steps: mixing a composite plant extract, inorganic salt, water and a composite probiotic agent for fermentation culture, and centrifuging, filtering and sterilizing a culture product to obtain the white truffle fermentation product, the strains in the compound probiotic agent comprise a combination of streptococcus thermophilus, saccharomyces cerevisiae boulardii, a plant lactobacillus YK-L002 strain and a saccharomyces cerevisiae YK-S001 strain. According to the invention, specific strains are subjected to compounding and combined fermentation, and the fermentation product filtrate obtained after fermentation treatment of four bacteria has an excellent skin conditioning effect, can effectively improve the skin state, significantly resist oxidation and resist and weaken wrinkles, and has an excellent effect when being applied to moisturizing and anti-oxidation cosmetics.
Owner:GUANGZHOU YOUKE BIOTECHNOLOGY CO LTD

Graminophyllum brasiliensis as well as fermentation method and application thereof

PendingCN121427747ABiocideAgriculture tools and machinesBiotechnologyStreptococcus pyogenes
The invention belongs to the technical field of microorganisms, and relates to a strain of herbaspirillum as well as a fermentation method and application thereof. The invention provides a strain of brassica juncea, the brassica juncea is brassica juncea YLHb25.7, the brassica juncea is named as Herbaspiril huttiense, the brassica juncea is preserved in China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC No.35297. The invention also provides a preparation method of the brassica juncea. The herbispirillum sp. YLHb25.7 disclosed by the invention has the capabilities of producing ACC deaminase, producing IAA and fixing nitrogen, and has good drought resistance and saline-alkaline tolerance. The herbaspirillum sp. YLHb25.7 and the fermentation product thereof can promote the growth of wheat and corn, can be used as a microbial agent or bacterial fertilizer, and can be applied to the agricultural market.
Owner:NORTHWEST A & F UNIV

Esophageal adenocarcinoma plasma circulation microbial marker combination, reagent, kit, risk prediction model and application thereof

The invention discloses an esophageal adenocarcinoma plasma circulation microbial marker combination, a reagent, a kit, a risk prediction model and application thereof, and belongs to the cross technical field of liquid biopsy and microbiomics. The esophageal adenocarcinoma plasma circulating microbial marker combination disclosed by the invention comprises enterobacteriaceae, cilia, prevotella, ackermania, lactobacillus fermentum and streptococcus. When the esophageal adenocarcinoma plasma circulating microbial marker combination is used for verifying esophageal adenocarcinoma patients and healthy controls, the AUC is 0.952, the sensitivity is 100%, the specificity is 80.00%, the accuracy is 91.43%, the positive predictive value is 86.96%, and the negative predictive value is 100%; the esophageal adenocarcinoma plasma circulating microbial marker combination can effectively distinguish esophageal adenocarcinoma patients from healthy people, is suitable for early screening of esophageal adenocarcinoma, and has remarkable clinical screening application value.
Owner:BEIJING XUTENG GENE TECHNOLOGY CO LTD

Phytobacterium plantarum TRT-01 with anti-inflammatory and bacteriostatic functions as well as preparation method and application of phytobacterium plantarum TRT-01

The invention relates to the field of microorganisms, in particular to lactobacillus plantarum TRT-01 with anti-inflammatory and bacteriostatic functions as well as a preparation method and application of the lactobacillus plantarum TRT-01, the lactobacillus plantarum TRT-01 is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.32237, and the preservation date is October 17, 2024. The plant lactobacillus has broad-spectrum bacteriostatic activity on 10 pathogenic bacteria such as helicobacter pylori, streptococcus mutans and the like, and can regulate Th1 / Treg immune balance and relieve inflammatory response by inducing dendritic cells to secrete cell factors IL-10 and IL-12, inducing T cells to secrete cell factors TGF-beta and IFN-gamma and inhibiting secretion of cell factors IL-6 at the same time. Therefore, the plant lactobacillus TRT-01 disclosed by the invention can be used for preparing a composition with anti-inflammatory and bacteriostatic effects, is suitable for the fields of medicines, foods, health-care products and the like, and is particularly suitable for developing a microbial preparation with a probiotic effect.
Owner:BEIJING TONGRENTANG XINGAN HEALTH TECH CO LTD

Lactobacillus rhamnosus for improving oral health and application of lactobacillus rhamnosus

The invention relates to an oral microbiome regulation and control technology, in particular to lactobacillus rhamnosus capable of improving oral health and application of the lactobacillus rhamnosus. The preservation number of the LRa37 strain is CGMCC No.34558, the LRa37 strain is preserved in China General Microbiological Culture Collection Center on May 15, 2025, and the preservation address is No.3, No.1 Yard, Beichen West Road, Chaoyang District, Beijing. The LRa37 strain inhibits oral pathogenic bacteria through targeted inhibition of prevotella intermedia, streptococcus pasteurii and streptococcus parablood, improves oral micro-ecological balance and further improves the oral health state.
Owner:WUHAN WEIKANG PROBIOTICS RES INST CO LTD

Primer probe composition and kit for detecting lower respiratory tract infection pathogens

The invention belongs to the technical field of biology, and particularly relates to a primer probe composition and a kit for detecting lower respiratory tract infection pathogens. The primer probe composition is used for detecting mycobacterium tuberculosis, mycobacterium avium, mycobacterium abscessus, mycobacterium kansasii, pseudomonas aeruginosa, klebsiella pneumoniae, acinetobacter baumannii and haemophilus influenzae, and the primer probe composition is used for detecting mycobacterium tuberculosis, mycobacterium avium, mycobacterium abscessus, mycobacterium kansasii, pseudomonas aeruginosa, klebsiella pneumoniae, acinetobacter baumannii and haemophilus influenzae. The composition is one or more of a composition for detecting staphylococcus aureus, a composition for detecting streptococcus pneumoniae, a composition for detecting escherichia coli, a composition for detecting moraxella catarrhalis, a composition for detecting serratia marcescens, a composition for detecting mycoplasma pneumoniae, a composition for detecting candida albicans or a composition for detecting adenovirus; the RAA-RDB technology has the core advantages of rapidness, high sensitivity, low cost and easy operation, and is especially suitable for multiple pathogen screening and basic medical application.
Owner:WEIFANG MEDICAL UNIV

Complex microbial inoculant for fermenting modified corn flour, fermentation method and application

The invention provides a complex microbial inoculant for fermenting modified corn flour, a method and application, and belongs to the technical field of fermented food. The complex microbial inoculant comprises a liquid state fermentation complex microbial inoculant (streptococcus thermophilus is greater than or equal to 1 * 10 < 9 > cfu / mL and bacillus subtilis is greater than or equal to 1 * 10 < 9 > cfu / mL) and a solid state fermentation complex microbial inoculant (monascus spore suspension is greater than or equal to 1 * 10 < 6 > spores / mL and lactobacillus plantarum is greater than or equal to 1 * 10 < 8 > cfu / mL), and the fermentation modification method comprises the following steps: performing microwave puffing treatment on corn flour, mixing the corn flour with oat bran, and sequentially performing liquid state fermentation and solid state fermentation, and spraying the liquid fermentation supernatant back to the solid substrate, and finally drying to obtain the modified corn flour. Through the synergistic effect of a two-stage fermentation system, the content of functional components such as soluble dietary fibers and Monacolin K in the corn flour is remarkably increased, and the obtained product has the characteristic of lowering cholesterol.
Owner:INST OF FOOD PROCESSING HEILONGJIANG ACAD OF AGRI SCI

Postbiotic composition for effectively inhibiting dental caries in oral cavity and preparation method thereof

The invention belongs to the technical field of biomedical treatment and biological fermentation, discloses a metagen composition for effectively inhibiting oral dental caries and application thereof, and aims to solve the problems of great side effect, weak effect and unknown mechanism of the existing dental caries prevention and treatment means. The composition is prepared by mixing a metagen 1 which is prepared by fermenting lactobacillus salivarius Postbio-YY with a metagen 2 which is prepared by fermenting lactococcus lactis Postbio-F3 and lactobacillus paracasei Postbio-P6 step by step. In the preparation process, the active ingredients are reserved by accurately controlling the fermentation pH, time and pasteurization parameters. The composition can be prepared into multiple dosage forms such as toothpaste and the like, can remarkably inhibit the growth of streptococcus mutans and destroy the thallus structure, inhibits biofilm and exopolysaccharide synthesis by down-regulating fimI, wcaJ and wcae genes, is safe and free of side effects, and provides an efficient scheme for decayed tooth prevention and treatment.
Owner:YANGZHOU PERFECT DAILY CHEM

High-temperature-resistant and inflammation-relieving Witzia ciliaris CN985 and application thereof

PendingCN121472086AAntibacterial agentsBacteriaBiotechnologyStreptococcus pyogenes
The invention provides a strain of high-temperature-resistant and inflammation-relieving Witzia ciliaris and an application thereof, the high-temperature-resistant and inflammation-relieving Witzia ciliaris is Witzia ciliaris CN985 and is preserved in the China Center for Type Culture Collection (CCTCC), the preservation date is April 7, 2024, and the preservation number is CCTCC NO: M 2024641. The invention further provides a preparation method of the high-temperature-resistant and inflammation-relieving Witzia ciliaris strain for preventing and treating inflammation of the high-temperature-resistant and inflammation-relieving Witzia ciliaris strain for preventing and treating inflammation of the high-temperature-resistant and inflammation-relieving Witzia ciliaris strain. The invention provides a brand new strain of Witzia ciliaris CN985, which is resistant to high temperature, has better acid resistance and bile resistance, and has no hemolysis risk when being applied to a human body. The Witzia coagulans CN985 has excellent antibacterial performance, and especially can significantly inhibit streptococcus pyogenes, salmonella enteritidis and / or group B streptococcus; besides, experimental results show that the Witzia ciliaris CN985 can relieve enteritis, improve the immunity of the organism and relieve pharyngitis, and especially when the Witzia ciliaris CN985 and the phytobacterium plantarum CE18 are combined for use, the Witzia ciliaris CN985 and the phytobacterium plantarum CE18 have a synergistic interaction effect, so that the relieving effect on enteritis can be remarkably improved.
Owner:KEWEI BIOLOGICAL (ZHENJIANG) CO LTD

Double-milk-source fermented milk of double-peak camel milk and brown milk and preparation method of double-milk-source fermented milk

The invention discloses double-milk-source fermented milk of double-peak camel milk and brown milk and a preparation method of the double-milk-source fermented milk, and the preparation method comprises the following steps: mixing raw materials: mixing the double-peak camel milk and the brown milk according to a mass ratio to obtain double-milk-source mixed milk; pretreatment: sequentially carrying out homogenization treatment and heat treatment on the double-milk-source mixed milk; strain inoculation: inoculating the pretreated double-milk-source mixed milk with a fermentation strain, wherein the fermentation strain comprises a core strain and an auxiliary strain; the core strains are lactobacillus and streptococcus thermophilus which have tolerance to antibacterial components of the camel milk, and the core strains contain strains capable of producing exopolysaccharides. Through scientific matching of lactobacillus, streptococcus thermophilus and specific auxiliary strains which have tolerance to antibacterial components of the camel milk, the inhibition effect of natural antibacterial components such as lysozyme and lactoferrin in the camel milk on conventional strains is successfully overcome.
Owner:XINJIANG YIHA DAIRY FARM CO LTD

Streptococcus pneumoniae capsular polysaccharides and immunogenic conjugate thereof

The present invention provides an immunogenic composition comprising a Streptococcus pneumoniae polysaccharide-protein conjugate, comprising a capsular polysaccharide derived from one or more selected from the group consisting of serotypes 1, 2, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, and 33F, derived from Streptococcus pneumoniae; and one or 2 or more of carrier proteins conjugated to the respective capsular polysaccharide, and method of preparation thereof. Through one example of the present invention, an immunogenic composition for preventing or treating pneumococcal infection can be provided.
Owner:SK BIOSCI CO LTD

Multiplex PCR (Polymerase Chain Reaction) primer for simultaneously detecting eight respiratory tract pathogenic bacteria and application of multiplex PCR primer

The invention belongs to the technical field of bacterium detection, and discloses a multiple PCR primer for simultaneously detecting eight respiratory tract pathogenic bacteria and application thereof. On the basis of a Luminex liquid phase chip technology, specific primers are designed aiming at eight common respiratory tract infection pathogenic bacteria including pseudomonas aeruginosa, staphylococcus aureus, streptococcus pneumoniae, klebsiella pneumoniae, acinetobacter baumannii, stenotrophomonas maltophilia, haemophilus influenzae and escherichia coli; the multiple PCR primers which are high in amplification efficiency, good in specificity and suitable for simultaneously detecting the eight respiratory tract pathogenic bacteria are screened out, the multiple PCR system and microsphere hybridization conditions are continuously optimized, the multiple PCR method for the eight respiratory tract pathogenic bacteria is successfully constructed by applying the Luminex xTAG technology, and the multiple PCR method can be applied to rapid detection of multiple pathogenic microorganisms.
Owner:HEBEI MEDICAL UNIVERSITY

Traditional Chinese medicine composition for intervening in non-alcoholic fatty liver and preparation method thereof

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for intervening in non-alcoholic fatty liver and a preparation method thereof. The preparation method comprises the following steps: (1) weighing the following raw materials: hawthorn, salvia miltiorrhiza, rhizoma alismatis, radix puerariae, astragalus membranaceus, semen cassiae and poria cocos, and respectively crushing; (2) mixing radix astragali, semen cassiae and poria cocos, and performing water extraction to obtain concentrated paste; (3) preparing a fermentation substrate; (4) simultaneously inoculating lactobacillus rhamnosus and lactobacillus acidophilus into the fermentation substrate, and carrying out first-stage anaerobic fermentation; (5) continuously inoculating lactobacillus paracasei and streptococcus thermophilus into the fermentation liquid, and carrying out second-stage anaerobic fermentation; and (6) carrying out vacuum concentration, freeze drying and crushing on the traditional Chinese medicine fermentation liquor to obtain the traditional Chinese medicine fermentation composition for intervening in the non-alcoholic fatty liver disease. The traditional Chinese medicine composition is prepared through specific raw material compatibility and a specific fermentation mode, and a new path is provided for application of traditional Chinese medicine in the field of fatty liver treatment.
Owner:BEIJING GUOHUA XINYE TRADITIONAL CHINESE MEDICINE RES INST CO LTD

Method for preparing dendrobium officinale full-liquid yoghurt through ultrasonic synergistic composite enzymolysis method

The invention relates to a method for preparing dendrobium officinale full-liquid yoghurt by an ultrasonic synergistic composite enzymolysis method. The method comprises the following steps: selecting and treating raw materials; putting the dendrobium officinale stem slurry into an ultrasonic device, and then starting the ultrasonic device to carry out ultrasonic treatment on the dendrobium officinale stem slurry for a certain time; adding a compound enzyme mixture into the dendrobium officinale stem slurry subjected to ultrasonic pretreatment, and carrying out enzymolysis reaction to obtain enzymolysis slurry; terminating the enzymolysis reaction; filtering, centrifuging and collecting supernate to obtain dendrobium officinale whole liquid; performing freeze-drying treatment; adding the dendrobium officinale whole liquid freeze-dried powder into milk to form a mixed solution, and then adding streptococcus thermophilus and lactobacillus bulgaricus into the uniformly stirred mixed solution for fermentation to form the yoghourt. The method has the advantages that the physical wall breaking effect of ultrasonic waves and the biological catalysis effect of the compound enzyme are combined, so that the extraction efficiency of active ingredients such as polysaccharide, anthocyanin and amino acid in the dendrobium officinale stems is improved, and the biological activity of the ingredients is reserved to the maximum extent.
Owner:HANGZHOU YUHANG AGRICULTURAL TECHNOLOGY MIDDLE SCHOOL (HANGZHOU LIANGZHU VOCATIONAL SENIOR HIGH SCHOOL)

Bacillus velezensis, microbial preparation as well as preparation method and application of microbial preparation

The invention discloses bacillus velezensis, a microbial preparation as well as a preparation method and application of the microbial preparation, and relates to the technical field of microorganisms. The bacillus velezensis strain is preserved in the China Center for Type Culture Collection, and is named as bacillus velezensis XNW-BLSYB1, the preservation number is CCTCC NO: M 2025721, the preservation time is April 8, 2025, and the 16S rDNA sequence of the bacillus velezensis strain is as shown in SEQID No.1. The bacillus velezensis strain has the advantages that the bacillus velezensis strain is named as bacillus velezensis XNW-BLSYB1; the spore formed by the bacillus velezensis XNW-BLSYB1 strain can survive at high temperature, and can inhibit the reproductive and respiratory syndrome virus and inhibit the activity of bacteria such as streptococcus suis, infectious actinobacillus pleuropneumoniae, clostridium perfringens, pasteurella multocida and escherichia coli.
Owner:WUHAN SINOWAY BIOTECHNOLOGY CO LTD

Vaccine for protection against Streptococcus suis serotype 9, sequence type 16

ActiveUS12383610B2Bacterial antigen ingredientsAntibacterial agentsStreptococcus suis serotypeAntigen
The present invention pertains to a vaccine comprising in combination an IgM protease antigen of Streptococcus suis and a Streptococcus suis bacterin of serotype (9), sequence type (16), for use in a method for protecting pigs against a pathogenic infection with Streptococcus suis serotype (9), sequence type (16).
Owner:INTERVET INC

Raw material composition for preparing yogurt, yogurt, food and preparation method thereof

This invention discloses a raw material composition for preparing yogurt, yogurt, food, and a method for preparing the same. The raw material composition includes fermentation ingredients, additives, and a starter culture. The fermentation ingredients include 80-90 wt% soy milk; the additives include 0.1-0.4 wt% dietary fiber, 1-3 wt% natural starch, and 0.5-1.5 wt% coconut extract; the starter culture is used at 0.005-0.02 wt%, and includes *Streptococcus thermophilus*, *Lactobacillus delbrueckii* subsp. bulgaricus, *Lactobacillus casei*, and *Lactobacillus plantarum*. The yogurt of this invention has a good taste and flavor at room temperature, maintains a stable pH, and can be stored at room temperature for one month while ensuring the activity of lactic acid bacteria.
Owner:HEILONGJIANG FEIHE DAIRY CO LTD +1

Primer group, kit and method for simultaneously detecting 11 microorganisms and diagnosing chronic endometritis intrauterine infection

The invention provides a primer group, a kit and a method for simultaneously detecting 11 microorganisms and diagnosing chronic endometritis intrauterine infection. The primer group is used for detecting the existence of 11 chronic endometritis pathogens: chlamydia trachomatis, enterococcus faecalis, escherichia coli, trichomonas vaginalis, klebsiella pneumoniae, mycoplasma hominis, neisseria gonorrhoeae, staphylococcus, streptococcus, reproductive mycoplasma and ureaplasma urealyticum. The primer group is used for performing multiple joint detection on chronic endometritis related pathogens, has high specificity and sensitivity, and is adaptive to an endometrial tissue sample. The invention provides a method for simultaneously detecting 11 microorganisms for diagnosing chronic endometritis intrauterine infection, which comprises the following steps of: collecting an endometrial sample by adopting a disposable sterile endometrial sampler, detecting 11 microorganisms in the endometrial sample by adopting a multiplex PCR (Polymerase Chain Reaction) technology, and accurately detecting the intrauterine microbial infection condition. Meanwhile, more accurate technical support is provided for clinically identifying whether pathogenic bacteria causing chronic endometritis exist or not, and clinical doctors can comprehensively consider medication guidance conveniently.
Owner:浙江凯瑞思医疗科技有限公司

Affinity-enzyme linked assay for detection of bacterial toxins using desorption-ionization mass spectrometry

PCT designated stageWO2025247435A1Particle separator tubesMicrobiological testing/measurementFamily PeptostreptococcaceaeMass spectrometry measurement
This invention relates to a method for detecting the activity of a toxin produced by bacteria of the families Peptostreptococcaceae or Clostridiaceae using mass spectrometry, which comprises the following steps: a) providing a planar surface suitable for mass spectrometry measurement, with attached affinity molecules; b) incubating the planar surface from step a) with the substrate of the toxin to be detected, to bind the substrate to the affinity molecules; c) subsequently incubating the planar surface from step b) with a sample in which the active toxin is to be detected, in the presence of a modification compound, and incubating it for a time sufficient for the substrate to react with the modification compound in the presence of the active toxin, if present in the sample, to form a modified substrate if the active toxin is present in the sample; d) removing the remnants of the sample; e) subjecting the (modified) substrate on the planar surface to matrix-assisted laser desorption / ionization, ionizing it and subsequently measuring the mass spectrum of the (modified) substrate; f) analyzing the measured mass spectrum, such that if the measured mass spectrum corresponds to the non-modified substrate, the active toxin is not present, and if the measured mass spectrum corresponds to the modified substrate or a mixture of the modified and non-modified substrate, then the active toxin is present in the sample. The invention further relates to a device for the soft landing of affinity molecule ions onto a planar surface suitable for mass spectrometry for carrying out step a) of the above method.
Owner:UNIV KARLOVA V PRAZE +1

A sulfated arabinogalactan derived from *Streptococcus linearis*, its preparation method and application

This invention discloses an arabinogalactan sulfate derived from *Streptococcus filamentosa*, its preparation method, and its applications, belonging to the fields of natural product chemistry and marine biological resource development technology. The technical solution includes an arabinogalactan sulfate derived from *Streptococcus filamentosa*, with a monosaccharide composition comprising arabinose, galactose, and rhamnose, the molar percentage of arabinose being not less than 70%; the main chain backbone is modified with natural sulfate groups, with the sulfate groups replacing at least one hydroxyl site of the arabinose residues. This invention, when applied to anticoagulation, exhibits good safety and a significant anticoagulant effect.
Owner:SHANDONG ACAD OF MARINE SCI (QINGDAO NAT MARINE SCI RES CENT)

A moisturizing coating with flavor-enhancing function and its application in cigarettes

The present invention discloses an application of a moisturizing coating with a flavoring function on cigarettes. The moisturizing coating comprises: a composite bacterial solution, a tobacco polysaccharide solution, and a chitosan solution. The volume ratio of the composite bacterial solution, the tobacco polysaccharide solution, and the chitosan solution is (3-4): (2-3): (4-5). The composite bacterial solution is formed by mixing lactic acid streptococci, bacillus, and yeast in a certain proportion. In the moisturizing coating of the present application, the secondary metabolites of lactic acid streptococci can inhibit miscellaneous bacteria, chitosan is a natural and harmless antibacterial film, and tobacco polysaccharides themselves have moisturizing properties. The composite bacterial solution can interact with tobacco polysaccharides and chitosan to better inhibit miscellaneous bacteria, and the protective film has a better protective effect. The metabolites of bacillus and yeast produce aroma-causing substances during the combustion and cracking process of cigarettes, thereby increasing the aroma of cigarettes.
Owner:CHINA TOBACCO HENAN IND CO LTD

Application of pantothenic acid in the preparation of anti-caries preparations related to Streptococcus mutans and anti-caries preparations containing pantothenic acid

The present invention discloses the use of pantothenic acid in the preparation of anticaries preparations related to Streptococcus mutans, and anticaries preparations containing pantothenic acid. The invention belongs to the field of biomedicine technology. The anticaries preparations related to Streptococcus mutans include an acid production inhibitor for Streptococcus mutans, a growth inhibitor for Streptococcus mutans, an inhibitor of cariogenic toxins of Streptococcus mutans, and an inhibitor of interspecies competition of Streptococcus mutans. Pantothenic acid can be used to influence the acid production, growth, production of cariogenic toxins, and interspecies competition of Streptococcus mutans, thereby maintaining the balance of the oral microecology.
Owner:SICHUAN UNIV

Fermentation complex microbial inoculant, preparation method and application thereof

The application discloses a kind of fermentation complex microbial inoculant and preparation method and application thereof, the fermentation complex microbial inoculant includes the following weight parts of component: bacillus subtilis microbial inoculant 2-5 parts, bacillus mucilaginosus microbial inoculant 5-10 parts, yeast microbial inoculant 2-10 parts, trichoderma harzianum microbial inoculant 10-20 parts, aspergillus niger microbial inoculant 10-20 parts and streptococcus thermophilus microbial inoculant 2-5 parts;The fermentation complex microbial inoculant of the application is prepared by selecting each strain and amount, is added to pigeon manure and is fermented to prepare organic fertilizer, can better decompose macromolecular substance, significantly improve the organic matter and total nitrogen content in preparation organic fertilizer, and can better improve seed germination rate;In addition, the preparation method of pigeon manure organic fertilizer of the application is simple in process, easy to operate, and convenient for production.
Owner:SHANGHAI ANIMAL EPIDEMIC PREVENTION & CONTROL CENT

A Pediococcus acidilactici YYS-J2 capable of degrading acrylamide and producing high phenyllactic acid and its application

The present invention relates to the field of microbial technology, and provides a Pediococcus acidilactici YYS-J2 that can degrade acrylamide and produce high levels of phenyllactic acid, and its application. Pediococcus acidilactici The preservation number of YYS-J2 is CGMCC No. 28183. This *Pediococcus lactis* YYS-J2 exhibits excellent acrylamide removal capacity, high efficiency in L-phenylalanine utilization and metabolism, high-quality phenyllactic acid production capacity, and excellent *Streptococcus mutans* antibacterial activity. It also produces superoxide dismutase (SOD) and shows good tolerance in simulated gastric and intestinal fluids. This *Pediococcus lactis* YYS-J2 can provide a new probiotic source for the development of functional products such as acrylamide removal products, antibacterial products, and SOD-producing products, and has significant application value.
Owner:XIAMEN YUANZHIDAO BIOTECHNOLOGY CO LTD

Silver / schiff base-based antibacterial material, preparation method and application thereof

ActiveCN116649365BBiocideDisinfectantsAntimicrobial actionStreptococcus sanguinis
The application discloses a silver / schiff base antibacterial material, a preparation method and application, and relates to the field of antibacterial materials.The silver / schiff base antibacterial material, the preparation method and the application are characterized in that, based on the large electron cloud density of the carbon-nitrogen double bond of the schiff base, silver ions in a silver nitrate solution are uniformly adsorbed on a schiff base base through the electrostatic adsorption principle; under the reduction of a reducing agent, the silver ions are reduced to nanosilver ions, and a silver / schiff base antibacterial material is obtained, in which nanosilver ions in the form of nanospheres are uniformly dispersed on the schiff base in the form of a thin sheet layer, thereby greatly improving the dispersibility of the nanosilver ions.The preparation method is simple, low in cost, and capable of batch production, and has no cytotoxicity, and has high antibacterial effects on streptococcus, pseudomonas aeruginosa and staphylococcus aureus, and has a good application prospect.
Owner:QUZHOU RES INST OF ZHEJIANG UNIV

Natural pigment lactic acid bacteria microcapsule as well as preparation method and application thereof

The invention belongs to the technical field of biology, and discloses a natural pigment lactic acid bacteria microcapsule which is composed of a wall material and a core material, and the wall material is composed of whey protein isolate and Arabic gum; the core material comprises a natural pigment and lactic acid bacteria, and the natural pigment is one or two of chlorophyll, beet and sodium copper chlorophyllin; the lactic acid bacteria are one or a combination of more of lactobacillus plantarum, lactobacillus bulgaricus and streptococcus thermophilus. According to the natural pigment lactic acid bacteria microcapsule, the natural pigment and the lactic acid bacteria are co-embedded, the natural pigment can promote the growth of the lactic acid bacteria and improve the embedding rate, when the natural pigment lactic acid bacteria microcapsule is used for preparing yoghourt, the brightness, the water-holding capacity, the viscosity and the acidity of the yoghourt can be improved, and the DPPH and ABTS free radical scavenging rate of the yoghourt can be improved; in addition, the natural pigment lactic acid bacteria microcapsules can better protect lactic acid bacteria, so that the shelf life of the yoghourt is prolonged. Meanwhile, the invention further discloses a preparation method and application of the natural pigment lactic acid bacteria microcapsule.
Owner:JIANGSU UNIV