123results about How to "Avoid infection" patented technology

The invention relates to a novel three-antigen HSV-2 subunit vaccine as well as a preparation method and application thereof, and belongs to the technical field of biology. The novel three-antigen HSV-2 subunit vaccine comprises antigens and a composite adjuvant, the antigens comprise HSV-2 gB2 envelope glycoprotein, HSV-2 gC2 envelope glycoprotein and HSV-2 gD2 envelope glycoprotein, and the composite adjuvant is CpG oligonucleotide and an aluminum adjuvant; the vaccine provided by the invention can induce a high-level neutralizing antibody, and widens targets for developing a novel multi-target antigen HSV-2 virus vaccine.

The invention discloses a pig farm sewage treatment system and method, and belongs to the technical field of farm sewage treatment, the pig farm sewage treatment system sequentially comprises a water collecting tank, a dosing mixing tank, a solid-liquid separator, an adjusting tank, a HiRAD anaerobic device, a reaction sedimentation tank, a water quality adjusting tank, an SBR biochemical tank, a C-MBR biochemical tank, a disinfection tank and a reuse water tank; by means of the system and the method, sewage discharged by the pig farm through the liquid manure technology can be effectively purified, organic carbon in the sewage can be converted into methane to the maximum extent, the methane becomes a high-quality biomass resource, waste is turned into wealth, emission of toxic gas is avoided, it is guaranteed that the pig farm is clean and sanitary, and the economic benefits of the pig farm are improved. Infection and spreading of diseases are avoided; meanwhile, a large number of nutrient sources, such as nitrogen and phosphorus, in the sewage are converted into organic fertilizer; the purified wastewater is deeply cleaned, so that the recycling standard is met, and the cyclic utilization of resources is realized.

This invention discloses a polypeptide that specifically binds to the coronavirus S protein, its encoding gene, and its applications, belonging to the field of molecular biology. The polypeptide specifically binding to the coronavirus S protein provided by this invention contains the following amino acid sequence: HFVKTPARWAWG, obtained through screening using phage display technology. The polypeptide provided by this invention can specifically bind to the coronavirus S protein and specifically block the binding of the coronavirus S protein to ACE2, thereby inhibiting coronavirus infection and can be used to prepare anti-coronavirus drugs.

This invention discloses a method for producing crop cultivation substrate using sugarcane filter mud and sugarcane pith as main raw materials, comprising the following steps: (1) dissolving and diluting 4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid in water to obtain a solution; (2) mixing sugarcane slurry, sugarcane pith, the 4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid solution, fermentation agent, and improver, adjusting the moisture content, and then composting and fermenting. The compost is turned over every few days and continuously composted and fermented for several days to obtain the crop cultivation substrate. The crop cultivation substrate produced by this invention is of excellent quality, allowing direct planting of plants without root burn. Therefore, this invention, using sugarcane filter mud and sugarcane pith as main raw materials to prepare and produce crop cultivation substrate, can effectively solve the problem of comprehensive utilization of sugarcane filter mud and improve product sales.

The application relates to a double-metal hydroxide, in particular to application of a CuAl double-metal hydroxide, in particular to application of the CuAl double-metal hydroxide in preparation of a preparation for inactivation of pathogenic bacteria, fungi and viruses. The CuAl double-metal hydroxide is prepared by a formamide liquid phase stripping method. Compared with the prior art, the application solves the problem of high cost of a silver ion loaded layered double-metal hydroxide in the prior art, and realizes preparation of a low-cost, high-performance and green antibacterial material with a bactericidal and antiviral effect.

This utility model relates to the field of medical device technology and discloses a dressing change kit for infants and young children with persistent seepage at deep vein catheter insertion sites. The kit includes a dressing bag, an inner wall with a sterilization pack, a skin protective dressing, an exposed catheter patch, and a sterile gauze sleeve. Elastic strips are fixedly connected to both the front and back sides of the sterile gauze sleeve. A hemostatic component for the puncture site and continuous bleeding is provided on the inner wall of the dressing bag. This hemostatic component includes a stretchable adhesive tape, the outer side of which is placed on the inner wall of the dressing bag. A pressable circular plate is fixedly connected to the bottom of the stretchable adhesive tape. In this utility model, the operator passes the catheter through the skin protective dressing, the exposed catheter patch wraps around the dialysis catheter, and then the dialysis catheter is inserted into the sterile gauze sleeve, thus securing the dialysis catheter and achieving fixation of the catheter, which cannot be cut.

The present application relates to the technical field of biological materials, in particular to a light-responsive drug gel carrier and a preparation method thereof, in order to improve the controlled release function of the hydrogel material, the methyl methacrylate nitrobenzene compound containing nitrobenzene structure, hydantoin structure and propylene structure is prepared first, under the action of a photoinitiator, the double bond is crosslinked with methyl methacrylate and ethylene glycol methacrylate to form a hydrophilic gel network, so that the drug gel carrier is obtained; wherein the nitrobenzene structure has photosensitivity, and the crosslinking structure will be broken under ultraviolet irradiation, thereby reducing the stability of the gel material, destroying the rearrangement of the gel micelle structure, and realizing the release of the loaded drug; and the hydantoin structure introduced in the methyl methacrylate nitrobenzene compound also has good antibacterial performance, which can effectively avoid wound infection and improve wound recovery.

The utility model discloses an ear penetrating device with a hollow pipe, and belongs to the technology of accessory accessories. The ear penetrating device with the hollow pipe comprises a pushing piece, a clamping piece, a piston piece and an elastic piece. The pushing part is provided with a first cavity and a second cavity, the clamping part is located in the first cavity and comprises a first clamping head and a second clamping head, and the hollow pipe is fixed between the first clamping head and the second clamping head. The piston piece is provided with an installation part used for installing the ear stud base and a guide part capable of extending into the second cavity in a sliding mode, and when the guide part slides along the second cavity, the installation part drives the ear stud base to be connected with the hollow pipe. An ear stud is replaced by the hollow pipe, and the hollow pipe is connected to the ear stud seat. After installation, the diameter of the through groove of the hollow pipe is larger than that of the rod body of the ear stud, the through groove is used for inserting the ear stud, and different ear studs can be used conveniently. And the hollow pipe is arranged, so that an operator can be prevented from frequently contacting the ear stud rod body when using the ear penetrating device, and infection is avoided.

The application of 2-[(7-hydroxy-8-methyl-2-oxochrome-4-yl)methylthiosulfase]-4,6-dimethylpyridine-3-carbamate in the treatment of Ebola virus belongs to the field of pharmaceutical technology. This invention addresses the technical problem of the lack of effective anti-Ebola virus drugs in the prior art by providing 2-[(7-hydroxy-8-methyl-2-oxochrome-4-yl)methylthiosulfase]-4,6-dimethylpyridine-3-carbamate, which can effectively inhibit Ebola virus replication within a non-toxic range. The compound exhibits good anti-infective effects against SUDV, BDBV, and TAFV viruses and can be used to prepare safe and effective broad-spectrum anti-Ebola virus drugs.

This invention discloses a protective garment for epicondylitis of the humerus based on an antibacterial and thermally conductive composite material, belonging to the field of medical protective gear technology. It includes a forearm support and an upper arm support, which are rotatably connected by an adjusting mechanism. The upper arm and forearm sleeves are 3D printed using an antibacterial and thermally conductive composite material, which comprises a polylactic acid matrix, a graphene oxide-silver nanoparticle-carbon nanotube ternary composite filler, and phase change microcapsules, with a thermal conductivity of 1.5-4.0 W·m. ‑1 ·K ‑1 With an antibacterial rate of ≥95%, it solves the problems of poor thermal conductivity, lack of antibacterial properties, and uneven heat therapy in existing protective gear.

The utility model discloses a safe USB flash disk with a hardware isolation function, and aims to solve the problem that a USB flash disk in the prior art is not easy to carry out targeted reading and writing according to the type of a computer. According to the utility model, through the USB flash disk shell, the interface, the single chip microcomputer, the relay, the serial port module, the storage unit and the like, the matching of the interface, the relay and the single chip microcomputer is utilized, a serial port custom protocol is utilized, and verification and identification are carried out on an upper computer software computer, so that the possibility that the USB flash disk is connected with the Internet is avoided, and the isolation effect of the USB flash disk between internal and external network elements is realized; therefore, the USB flash disk is effectively prevented from being infected with viruses, meanwhile, the problem that the USB flash disk is firstly connected with storage data in the plugging process of a common computer end is further avoided by utilizing the connection effect of the serial port module and the normally closed node of the relay, and the isolation effect of the USB flash disk between different hardware is further achieved.

This utility model relates to the field of medical devices, and more particularly to an electric hospital bed with anti-bedsore function. It includes a bed frame, an ultraviolet disinfection box, an ointment storage container, a cleaning chamber, and a waste collection chamber. The ultraviolet disinfection box is connected to the front left side of the bed frame, and the ointment storage container is placed on top of the ultraviolet disinfection box. The cleaning chamber is connected to the front middle side of the bed frame, and the waste collection chamber is connected to the front right side of the bed frame. This utility model uses the ultraviolet disinfection box to disinfect the ointment application board, then uses the application board to scoop out the ointment from the storage container and apply it to the patient. After use, the application board is inserted into the cleaning chamber and held in place by clamps. It is then cleaned by rotating a cleaning brush head. After cleaning, it is disinfected again, and wastewater is collected. This allows for simultaneous cleaning and disinfection of the application board and convenient application of medication to the patient, ensuring treatment continuity, facilitating rapid cleaning of the application board, preventing contamination and infection, and improving the convenience and efficiency of nursing procedures.

The utility model discloses a silica gel indwelling needle patch, and relates to an indwelling needle patch. Comprising a recording strip, release paper, a polyurethane film layer, a microporous silica gel layer, a silica gel adhesive tape strip and an embossed protective layer, the release paper is divided into a first part and a second part, the first part of the release paper is adhered to the polyurethane film layer, an opening is formed in the center of the first part, and the recording strip is arranged on the outer surface of the second part of the release paper; the polyurethane film layer is adhered to the microporous silica gel layer; one surface of the embossed protective layer is divided into a first area and a second area, and the microporous silica gel layer and the silica gel adhesive tape strip are respectively adhered to the first area and the second area of the embossed protective layer. Due to the adoption of the design of the microporous silica gel layer, the air permeability of the indwelling needle patch is improved, the risk of curling and falling off is reduced, the comfort and the fitting feeling of a product are improved, the irritation and the injury to the skin of a patient are reduced, the practicability is improved, and the indwelling needle patch has certain advantages.

This invention provides the application of tea polysaccharide prepared by fermentation of Ganoderma lucidum in the preparation of drugs for the prevention and treatment of varicella-zoster virus infection. The tea polysaccharide is an acidic polysaccharide, abbreviated as FTP, with a molecular weight of 3.51 × 10⁻⁶. 5 The monosaccharide composition and ratio of Da are: Xyl:GalA:Glc:Gal:Rha:Man = 4.99:4.43:3.44:2.81:1.69:1. This invention, through a series of biological experiments, discovered and proved that fermented tea polysaccharide FTP has a significant anti-VZV effect at doses without obvious cytotoxicity, is safe and effective, and holds promise for development as a drug for the prevention and treatment of VZV.

This invention belongs to the field of traditional Chinese medicine technology and discloses drugs and methods of administration for preventing and treating viral infections and tumors. The drugs for preventing and treating viral infections and tumors are divided into two components. By weight, component one includes 0.5-25 parts of ginseng, 1-20 parts of astragalus, 1-18 parts of gastrodia, 1-24 parts of earthworm, 1-26 parts of chuanxiong, 0.1-15 parts of salvia miltiorrhiza, 0.1-10 parts of borneol, 1-28 parts of notoginseng, 1-32 parts of pinellia, 0.1-14 parts of centipede, and 0.1-17 parts of leech. Component two includes 1.5-2.5 parts of borax, 0.5-1.5 parts of potassium nitrate, 1.5-2.5 parts of sal ammoniac, 2-4 parts of agarwood, 4-6 parts of malachite, and 2-4 parts of borneol. This invention combines prevention and treatment. For uninfected individuals, the first component spray can effectively prevent viral infection, while for confirmed patients, the second component powder can kill viruses and tumors, resulting in good therapeutic effects and preventing the disease from worsening and spreading.

The utility model discloses an L-shaped extension tube of a breathing machine. The L-shaped extension tube comprises a sputum suction tube connector and a connector breathing machine connecting tube communicated with a sputum suction tube. An anti-splashing front film is arranged at the top of the sputum suction tube connector, a sputum suction hole allowing a sputum suction tube to be inserted is formed in the anti-splashing front film, an anti-splashing bottom film located below the anti-splashing front film is arranged in the sputum suction tube connector, and one side of the anti-splashing bottom film is fixedly connected with the anti-splashing front film. The anti-splashing bottom film has the initial state that the anti-splashing bottom film is attached to the lower portion of the anti-splashing front film when not stressed and the offset state that the other side of the anti-splashing bottom film is pushed by external force to move downwards. When the sputum suction tube needs to be inserted, the side, not connected with the anti-splashing front membrane, of the anti-splashing bottom membrane is pushed to move downwards due to insertion of the sputum suction tube, the anti-splashing front membrane is kept in the original position, and when the sputum suction tube is inserted and pulled out, due to double-layer blocking of the anti-splashing front membrane and the anti-splashing bottom membrane, the anti-splashing front membrane is prevented from splashing. Liquid can be prevented from being splashed out of the sputum suction tube connector, and operation safety is guaranteed.

This invention discloses a Karl Fischer titrator, relating to the field of chemical analysis instrument technology. It includes a detection stage, a titration flask, a homogenization unit, an anti-fouling unit, and a titration unit. The detection stage provides a mounting base for the titration flask, which holds the reaction solution. The homogenization unit homogenizes the reaction solution, the anti-fouling unit recirculates any residue adhering to the wall back into the reaction solution, and the titration unit controls the amount of Karl Fischer solution added. During titration, the homogenization unit is activated, driving the titration unit to add the Karl Fischer solution to the titration flask while simultaneously homogenizing the solution to prevent dead zones. The anti-fouling unit recirculates any residue adhering to the wall back into the reaction solution, preventing droplets from being unable to participate in subsequent reactions, thus avoiding detection errors and waste.

The invention belongs to the technical field of special medical food, and relates to application of common turnip in products for inhibiting gastrointestinal tract helicobacter pylori. The common turnip extract has the function of treating or preventing helicobacter pylori infection, has a good improvement effect on prevention and inhibition of gastroenteritis caused by helicobacter pylori, remarkably improves the function of a digestive system, and can be used for preventing and treating the gastroenteritis caused by the helicobacter pylori and preventing and treating the gastroenteritis caused by the helicobacter pylori. And support is provided for developing novel dietary nutrition supplements, functional foods, special medical foods and pharmaceutical compositions for inhibiting helicobacter pylori. The invention further discloses a synergistic effect of a medicinal and edible composition formed by combining the common turnip extract with extracts of clove, codonopsis pilosula, hericium erinaceus, fructus amomi and the like on inhibition of helicobacter pylori, and a greater effect of inhibiting the activity of the helicobacter pylori can be achieved. The novel product for inhibiting helicobacter pylori developed by the invention has both safety and effectiveness, and has a very good application prospect.

This invention discloses a high-throughput screening method for monkeypox virus (MPXV) N7-methyltransferase (N7-MTase) inhibitors based on fluorescence polarization technology and its application. This method uses MPXV E1... CTD Using the / E12 protein complex as a target, and leveraging the specific binding characteristic of the fluorescent probe FL-NAH to the target catalytic center, small molecule inhibitors that competitively bind to the SAM binding site are screened by monitoring changes in fluorescence polarization signals. This invention yielded a series of candidate compounds with significant inhibitory activity. Experiments demonstrated that these inhibitors exhibit strong inhibitory effects on MPXV N7-MTase, with a biochemical IC50 level of [missing information]. 50 Preferably, the concentration can reach 4.65 μM; at the cellular level, the compound exhibits a clear attenuation effect against poxviruses, with an EC50 value of [missing value]. 50 The range is up to 46.75 μM, and it has low cytotoxicity (CC). 50 >200 μM).

This invention discloses a targeted adjuvant influenza vaccine composition for atrial fibrillation patients with atrial fibrosis. The vaccine antigen components are selected from the surface antigens of currently prevalent influenza virus strains, such as hemagglutinin (HA) and neuraminidase (NA). High-purity influenza virus antigens are prepared through cell culture or recombinant DNA technology. For example, influenza virus is cultured using Madin-Darby canine kidney (MDCK) cells, and purified through centrifugation, filtration, and chromatography to obtain high-purity HA and NA antigens. After injection into the human body, the influenza virus antigens (HA and NA) are taken up and processed by antigen-presenting cells (such as macrophages and dendritic cells). The antigen-presenting cells present antigen peptides to T lymphocytes and B lymphocytes, activating a specific immune response. B lymphocytes differentiate into plasma cells with the help of T lymphocytes, producing specific antibodies that recognize and bind to the influenza virus, preventing it from infecting host cells and thus preventing influenza virus infection.

The invention belongs to the field of feed additives, and particularly relates to a nano feed additive for improving intestinal flora and a preparation method thereof.The preparation method comprises the following steps that (1) an electric arc furnace with pure copper as an anode and a graphite rod as a cathode is provided, absolute ethyl alcohol is injected into the furnace body in the vacuum state in the electric arc furnace, the arc starting current is controlled to be 40-60 A, and the temperature is controlled to be 20-30 DEG C; and purifying in an argon atmosphere for 12-48 hours to obtain the Cu-coated C nano-particles. And (2) carrying out oxidation reaction on the Cu-coated C nano-particles in an oxygen-containing atmosphere at the reaction temperature of 200-350 DEG C for 1-5 hours to obtain an oxidized product, namely the nano feed additive. The nano feed additive disclosed by the invention can be used for preventing and treating bacterial infection, enhancing the immune function and the anti-oxidative stress function of an organism, improving intestinal flora and prolonging the service life of animals, is an effective and safe functional feed additive, is simple in preparation method and low in production cost, can realize large-scale preparation, and has an important application prospect.

The invention relates to an oxazole compound as shown in a formula (I), a preparation method thereof and application of the oxazole compound in prevention and treatment of plant diseases. Particularly relates to an oxazole compound capable of inhibiting formation of fungus and oomycete appressorium, a preparation method of the oxazole compound and application of the oxazole compound to prevention and treatment of plant diseases caused by fungi and oomycetes.

This invention discloses a method for the rapid asexual propagation of a new ginger lily variety, comprising the following steps: obtaining rhizomes; treating with gibberellin, stacking several layers of rhizomes in a frame by layering them with wet straw, and then placing the frame containing the rhizomes and straw in a dark environment to promote germination; removing rhizomes with sprouting buds, quickly dipping them in a chlorpyrifos solution, and then cultivating them in a shaded area with humidity, allowing the stem buds to grow and differentiate into root tip tissue; uniformly spraying a growth regulator solution onto the surface of the rhizomes and stem buds, cultivating them in a shaded area with humidity, allowing the stem buds to grow into seedlings, dividing the rhizomes to obtain seedlings with complete root systems, and transplanting them; neatly arranging the transplanted seedlings on a seedbed in a shaded area, cultivating them with humidity, watering with a hymexazol solution at regular intervals, spraying foliar fertilizer when the seedlings develop leaves, and transplanting or releasing them from the nursery when the leaf and stem height reaches the standard. Advantages include: balancing the speed and seedling survival rate of asexual propagation of ginger lily, improving the propagation coefficient and seedling quality of the 'Huayao' ginger lily.

The invention belongs to the technical field of African swine fever treatment, and particularly relates to novel application of a compound C75 in preventing or treating African swine fever. It is found that the compound C75 can inhibit transcription of an African swine fever virus structural protein p72 and reduce the expression level of virus proteins p72 and p30, and has the effect of inhibiting African swine fever virus infection; the compound can be used for preparing drugs or adjuvants for resisting African swine fever virus infection and inhibiting replication of African swine fever viruses.

The present application relates to a kind of antibacterial and anti-adhesion catheter based on intelligent response nanofiber membrane, which is composed of medical polymer catheter substrate, silane coupling agent transition layer grafted on the outer surface of the substrate and nanofunctional fiber membrane layer formed on the outer surface of the transition layer by electrospinning process, the nanofunctional fiber membrane layer is composed of polyvinyl alcohol loaded hyaluronic acid grafted copper-doped carbon dots (CCDH), CCDH takes copper-doped carbon dots as core, and forms core-shell structure by grafting hyaluronic acid on the surface. The present application solves the problem of easy peeling of catheter coating by chemical bonding, and the formed antibacterial and anti-adhesion catheter has very low water contact angle and friction coefficient, not only effectively blocks the initial adhesion of bacteria at the physical level by constructing hydration layer, but also releases copper ions and carbon dots by enzymatic hydrolysis of hyaluronic acid under bacterial infection microenvironment, induces the production of reactive oxygen species to kill bacteria efficiently, and has broad application prospect in reducing the risk of catheter-related urinary tract infection.

This application discloses a K47 type Klebsiella pneumoniae capsular polysaccharide monoclonal antibody, its hybridoma cell line, and its applications. The sequence information of the K47 type Klebsiella pneumoniae capsular polysaccharide monoclonal antibody is shown in SEQ NO:1 to SEQ NO:2. As shown in NO:48, the accession numbers of the hybridoma cell lines are CCTCC:C2023296, CCTCC:C2023311, CCTCC:C2023312, CCTCC:C2023313, CCTCC:C2023314 and CCTCC:C2024339, respectively. The K47 Klebsiella pneumoniae capsular polysaccharide monoclonal antibody provided in this application can specifically bind to the capsular polysaccharide of Klebsiella pneumoniae, which is beneficial for the typing of Klebsiella pneumoniae in clinical practice. In both in vivo and in vitro animal experiments, it has been shown to have excellent effects in the prevention and treatment of K47 Klebsiella pneumoniae infection, providing a way to solve the problems of Klebsiella pneumoniae infection and multidrug resistance. It has significant implications for the prevention, diagnosis and treatment of Klebsiella pneumoniae infection, and is of great value for the development of new generation Klebsiella pneumoniae drugs.

This invention discloses an integrated liquid diet supply and digestion monitoring system for gastrointestinal care. The system includes a core control module, a liquid diet supply module, a digestive status monitoring module, a multi-scenario adaptation module, a multi-device collaboration module, and a data management module. By constructing a three-tiered closed-loop system of "early warning-intervention-emergency care" to prevent aspiration, it achieves non-invasive automatic monitoring of gastric residual volume, personalized customization and infusion linkage of liquid diet formulas, linkage between intermittent infusion and oral care, and full-process traceability analysis of abnormal events. It is portable and can interconnect with multiple devices such as smart beds, monitors, and hospital HIS / LIS systems to form a smart medical ecosystem. This invention achieves the integration and intelligentization of liquid diet supply, digestion monitoring, and gastrointestinal care, covering four major scenarios: hospitals, rehabilitation centers, nursing homes, and homes. It significantly improves diagnostic and treatment efficiency and patient comfort, meeting both clinical needs and quality control research requirements.

A dialysis concentrated solution preparation system comprises a main machine, a dialysis powder bag body and accessories, the main machine is an all-in-one machine and comprises a plurality of independently controlled dissolution stations, each station is provided with a multi-mode dissolution device, and the multi-mode dissolution device integrates three working modes of a mechanical shaking mechanism, an ultrasonic generator and a magnetic stirrer. The hemodialysis powder bag body comprises a flexible bag body, the flexible bag body is designed to be foldable, and hemodialysis dry powder is contained in the flexible bag body. The dialysate can be prepared and used on site, and the efficient and flexible liquid preparation effect is achieved through the liquid preparation system.

The invention provides dsRNA capable of simultaneously targeting three key genes of botrytis cinerea and application of the dsRNA, and belongs to the technical field of crop disease prevention and control genes. The dsRNA can be used for simultaneously interfering the expression of three key genes, namely BcRpd3, BcNat1 and BcArd1, of botrytis cinerea. The dsRNA which interferes with the three genes at the same time can effectively prevent and control tomato gray mold and medicago sativa gray mold. The dsRNA provided by the invention can reduce the expression levels of three target genes at the same time, has a better prevention and treatment effect on gray mold compared with dsRNA only interfering any one of the three genes, can be used for effectively preventing and treating tomato gray mold and alfalfa gray mold, has a good market application prospect, and is worthy of popularization and application. Meanwhile, a theoretical basis is provided for multi-target dsRNA design and application of an RNAi technology to prevention and treatment of gray mold.

The invention discloses an application of a small molecule drug ATWLPPR Peptide TFA in resisting mycobacterium bovis infection, and belongs to the field of biological medicine, the small molecule drug ATWLPPR Peptide TFA is an agonist of a target host factor NRP1, and then the inhibition effect of the ATWLPPR Peptide TFA on mycobacterium bovis in vitro and in vivo is researched. An in-vitro bacterial loading titration result shows that the ATWLPPR Peptide TFA treatment can present dose-dependent inhibition of the mycobacterium bovis to adhere to A549 cells. Mouse experiment results show that ATWLPPR Peptide TFA treatment can inhibit mice from being infected with mycobacterium bovis, pathological injuries of mouse lung tissues are effectively relieved, and a brand new direction is provided for prevention and control of mycobacterium bovis.