275 results about "Genital tract" patented technology

The present invention relates to compositions and methods for the administration of lipid-based vehicles to treat various disorders, including bladder inflammation, infection, dysfunction, and cancer. In various aspects, the compositions and methods of the invention are useful for prolonged delivery of drugs, e.g., antibiotics, pain treatments, and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system, and other organs or body systems. In particular, the present invention relates to liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin, and toxins, such as botulinum toxin, for the treatment of bladder conditions, including pain, inflammation, incontinence, and voiding dysfunction. Further related are methods of using these vehicles alone or in conjunction with antibodies, e.g., uroplakin antibodies, to improve duration of liposome attachment, and provide a long-term intravesical drug delivery platform. The present invention specifically relates to antibody-coated liposomes that are useful for targeting specific receptors for drug, peptide, polypeptide, or nucleic acid delivery. In one particular aspect, the present invention relates to liposomes coated with antibodies against nerve growth factor (NGF) receptor and containing NGF antisense nucleic acids, which are used as a treatment for neurogenic bladder dysfunction.

PCT No. PCT / SE97 / 00610 Sec. 371 Date Dec. 8, 1998 Sec. 102(e) Date Dec. 8, 1998 PCT Filed Apr. 11, 1997 PCT Pub. No. WO97 / 37587 PCT Pub. Date Oct. 16, 1997Device and method for collecting endogenous gaseous nitric oxide (NO), in the urogenital tract, for example in the urinary tract and in the uterus and oviducts. According to one embodiment, a NO permeable, liquid impermeable inflatable body (16) is positioned in the urethra (5) surrounded by the prostate gland (17), whereby an additional inflatable body (4) positioned in the bladder (2) serves to seal off the bladder from the urethra and helps in the positioning of the device. The present invention further relates to a method and a system for use in the diagnosis of inflammatory states in said organs.

The present invention relates to a method for the early diagnosis of neoplastic disorders such as cancers as well as their precursor stages, particularly cancers of the respiratory tract, the urinary system, the reproductive tract, cancer associated with HPV infection or cancer of the anogenital tract, from solubilized body samples. The invention is also directed to test kits usable for this purpose as well as in-vitro diagnostic devices. The development of the kits and in-vitro diagnostic devices for the above purpose is also one aspect of the present invention.

The present invention is directed to non-pathogenic, oncolytic, recombinant polioviruses for the treatment of various forms of malignant tumors. The recombinant polioviruses of the invention are those in which the internal ribosomal entry site (IRES) of the wild type poliovirus was exchanged with the IRES of other picornaviruses, and optionally P1, P3 or the 3'NTR thereof was exchanged with that of poliovirus Sabin type. More particularly, the present invention is directed to the administration of the non-pathogenic, oncolytic, recombinant poliovirus to the tumor directly, intrathecally or intravenously to cause tumor necrosis. The method of the present invention is particularly useful for the treatment of malignant tumors in various organs, such as: breast, colon, bronchial passage, epithelial lining of the gastrointestinal, upper respiratory and genito-urinary tracts, liver, prostate and the brain. Astounding remissions in experimental animals have been demonstrated for the treatment of malignant glioblastoma multiforme, an almost universally fatal neoplasm of the central nervous system.

The invention discloses a full-automatic genital tract infection detection system which comprises a plurality of joint inspection cards for detecting a sample, an automatic supply unit, an automatic card dispatching unit, an automatic sample injection unit, an automatic transmission unit, an automatic incubation unit, a reagent injection unit, an automatic measuring and reading unit and an electrical control unit, wherein the electrical control unit controls automatic running of all the units through software of a computer. According to the full-automatic genital tract infection detection system disclosed by the invention, due to the processes of automatic card dispatching, automatic sample injection, automatic incubation, automatic measuring and reading and the like which are controlled through the computer, manual participation steps are reduced, the measuring and reading accuracy is improved, and the test speed of detecting more than a set number of samples per hour can be achieved.

The invention relates to the technical field of antibacterial gel, in particular to antibacterial gel and a preparation method thereof. The antibacterial gel per liter comprises the following raw materials: 1.7-1.9g benzalkonium chloride, 30-50ml glycerol, 0.1-1.3g menthol, 1-1.8g alums, 0.3-0.4g lactic acid, 2.5-5g carbomer, 3-6g traditional Chinese medicine extract and the balance of purified water. The antibacterial gel contains various anti-inflammatory, antibacterial and analgesic components; an antibacterial effect is best through a synergistic effect of the raw materials; the biocompatibility of the antibacterial gel meets GB / T 16886.11-2011; a microbiological indicator of the antibacterial gel meets GB 15979-2002; and the antibacterial gel is suitable for nursing of various vaginal bacterial infection, trichomonas infection, leukorrhea, monilial infection, cervix and genital tract or mucosal wound surface infection, promotes healing of a wound surface after cervical erosion physiotherapy, and is further suitable for internal hemorrhoid, external hemorrhoid, mixed hemorrhoid, anal fissure and anorectal postoperative nursing.

The invention discloses an integrated molecular nucleic acid POCT device and method. The integrated molecular nucleic acid POCT device is composed of a reagent card box and a card box support. Different cavities connected with one another are formed in the reagent card box, and each cavity corresponds to a valve switch for controlling opening and closing of liquid. The card box support provides switch opening and closing, piston motion, heating temperature measurement, card box existence determination and other functions for the reagent card box, and plays a role in supporting and positioning.The integrated device allows samples such as nasopharyngeal swabs, genital tract swabs, sputum and blood to be directly added without other treatment, and therefore integrated detection of sample input and result output is achieved. The device has the main characteristics that (1) the structure is simple, the cost is low, the operation is simple and convenient, and the whole process is finished in a closed manner, so that pathogenic bacteria and aerosol pollution are effectively prevented; (2) the integrated molecular nucleic acid POCT device is provided for field POCT; and (3) the cost performance is high, the preparation is simple, and grassroots and popular consumption are facilitated.

The invention relates to the technical field of antibacterial gel, in particular to chitosan antibacterial gel and a preparation method thereof. Each liter of the chitosan antibacterial gel comprises the following raw materials by weight: 5-30g of modified chitosan, 2.5-10g of carbomer, 1-1.8g of alum, 2-40g of glycerol, 0.3-10g of lactic acid, 0.1-0.8g of menthol and 2-8g of sodium carboxymethylcellulose. The chitosan antibacterial gel which is good in curative effect, can be used for preventing relapse of inflammation and is harmless to human body is prepared by using the synergistic effect of modified chitosan serving as a major raw material as well as carbomer, alum, glycerol, lactic acid and sodium carboxymethylcellulose serving as auxiliary materials, and is suitable for preventing, treating and nursing various vaginal bacterial infections, trichomonas infections, mixed infections, vulvitis, leucorrhea, candidal infection as well as wound infections of cervix uteri, genital tract and mucous membrane. By using the chitosan antibacterial gel, wound healing after physical treatment of cervical erosion is promoted, and nursing of vaginal dryness as well as cross infections in sexual intercourse and the like is improved.

The invention discloses a preparation method and an application of a tissue slice for observing temporal-spatial distribution of early embryo development in vivo. The preparation method comprises the following steps that 4% paraformaldehyde fixing, upward gradient ethanol dehydration, wax dipping, embedding, serial section, baking, dewaxing and downward gradient ethanol rehydration are performed in sequence on oviducts or uterine tissues which contain mice embryos in every period, and finally, after haematoxylin-eosin staining is performed on the tissues in the slice, neutral gum is used for sealing the slice, or after immunofluorescence histochemical staining is performed on the slice, a fluorescence resistant quenching sealing agent is used for sealing the slice. The tissue slice disclosed by the invention can be used for manufacturing a map of early mice embryo development and detecting the expression of Crb3 in the mice embryos in every period of development in vivo. The preparation method has the advantages that positions of all organs in the embryos can be relatively fixed, so that the position change of embryo cells in a genital tract and the continuity of embryo development can be conveniently observed, the structure is clear, and the tissue slice is convenient to store.

The present invention is directed to non-pathogenic, oncolytic, recombinant polioviruses for the treatment of various forms of malignant tumors. The recombinant polioviruses of the invention are those in which the internal ribosomal entry site (IRES) of the wild type poliovirus was exchanged with the IRES of other picornaviruses, and optionally P1, P3 or the 3'NTR thereof was exchanged with that of poliovirus Sabin type. More particularly, the present invention is directed to the administration of the non-pathogenic, oncolytic, recombinant poliovirus to the tumor directly, intrathecally or intravenously to cause tumor necrosis. The method of the present invention is particularly useful for the treatment of malignant tumors in various organs, such as: breast, colon, bronchial passage, epithelial lining of the gastrointestinal, upper respiratory and genito-urinary tracts, liver, prostate and the brain. Astounding remissions in experimental animals have been demonstrated for the treatment of malignant glioblastoma multiforme, an almost universally fatal neoplasm of the central nervous system.

The current invention provides improved methods and means for the treatment of virally induced intraepithelial neoplasias of the ano-genital tract, such as HPV induced vulvar-, cervical-, vaginal-, penile- and anal intraepithelial neoplasias (VIN, CIN, VAIN, PIN and AIN). The invention provides a method of treatment of a subject suffering from an anogenital intraepithelial neoplasia comprising at least the steps of first determining whether the subject has a T-cell reactivity for viral early antigens, in particular high risk type HPV antigens; and subsequently a local treatment of the neoplasia with immune modulating compounds eliciting local inflammation if the subject scores positive for the T-cell reactivity, preferably a CD4+response against HPV early antigens. The invention also comprises methods and means to induce or further stimulate a cellular immune response against HPV antigens, prior to or during treatment with the immune modulating compound capable of eliciting a local inflammatory response.

The invention provides a kit capable of proliferating and / or testing pathogens and application thereof and a pathogen testing method and device. The kit comprises at least two pairs of the following 13 pairs of primer sequences: SEQ ID NO:1 and SEQ ID NO:2, SEQ ID NO:3 and SEQ ID NO:4, SEQ ID NO:5 and SEQ ID NO:6, SEQ ID NO:7 and SEQ ID NO:8, SEQ ID NO:9 and SEQ ID NO:10, SEQ ID NO:11 and SEQ ID NO:12, SEQ ID NO:13 and SEQ ID NO:14, SEQ ID NO:15 and SEQ ID NO:16, SEQ ID NO:17 and SEQ ID NO:18, SEQ ID NO:19 and SEQ ID NO:20, SEQ ID NO:21 and SEQ ID NO:22, SEQ ID NO:23 and SEQ ID NO:24 and SEQ ID NO:25 and SEQ ID NO:26. By utilizing the kit, the method and / or the device, multiple pathogens can be tested simultaneously, results are accurate, the detection cost is low, and consumed time is short.

The invention relates to a compound Chinese traditional medicine granule used for treating chicken coccidiosis, including four medicines of southernwood, dichroa febrifuga, Chinese bulbul and radix astragali. The invention is mainly used for treating various chicken coccidiosis diseases and also is used for treating the symptoms of bloody stool of sick chicken, emaciation, poor growth, and laying decline of adult chickens caused by chronic coccidial infection. The invention has the efficacies of clearing away heat and toxic material; considering the short avian genital tract and the special physiological structure of inability to digest lignocellulose, the medicine is prepared into soluble granules which can quickly be dissolved into drinking water which is absorbed by sick chickens so as to achieve the purpose of quick effect.

The invention relates to the field of care products, and in particular to functional female care wet tissue and a preparation method thereof. The functional female care wet tissue is made by injecting the following raw material components into hydroentangle non-woven fabrics: functional probiotics, propylene glycol, polyhexamethylene biguanidine hydrochloride, moisturizing curing agent, essential oil and purified water. The functional female care wet tissue provided by the invention is used for cleaning female pudendum, due to specific formula ratio, the functional probiotics are introduced, the long-term activity of the probiotics is maintained, growth and reproduction of escherichia coli, staphylococcus aureus and candida albicans at the female pudendum are effectively inhibited, and the micro-ecological environment of the pudendum is reestablished. The functional female care wet tissue has the effects of gentle cleaning and soft nourishing, and can inhibit harmful bacterium infection at the female pudendum. By adopting the female care wet tissue, harmful bacterium growth can be well inhibited, the situation of pruritus, inflammation and the like caused by harmful bacterium infection at the female private part is reduced, the health of the female pudendum and the genital tract is effectively maintained, and the wet tissue is free of irritation or sensitization and is safe and effective.

A method for application of natural vaginal flora transplantation in treating gynecological inflammation is characterized in that feminine dysbacteriosis is recovered by means of the opsonization of normal feminine vagina probiotics florae on feminine vaginal diseases, so that the feminine urogenital tract health is maintained. The method is also characterized in that bacteria are used as an antibacterial agent, and the micro-ecology treatment method free of drug resistance and side effects is realized by maintaining the stability of feminine lower genital tract florae; the adopted preparation is a vaginal embolism which is easy to make, convenient to use and quite low in cost.

The invention provides an extraction-free direct amplification reagent for real-time fluorescent quantitation PCR and application thereof. The direct amplification reagent comprises the following components: sodium hydroxide (NaOH), Surfactin, dimethyl sulfoxide (DMSO), sucrose and chelex-100. When the reagent is used, there is no need to extract and purify nucleic acid from a sample, only the sample and the reagent need to be mixed according to the equal volume ratio of 1:1. The mixture can be directly used for fluorescent PCR detection. The extraction-free direct amplification reagent is applicable to nucleic acid extraction of human genome, bacteria and viruses in mouth swabs, nasopharyngeal swabs, serum, plasma, genital tract secretion and other samples. The reagent is suitable for both the fluorescence PCR of a probe method and the PCR of a dying method, is suitable for a variety of clinical applications and has the advantages of low cost, simple operation, accurate results and the like, and detection can be simple and quickly completed.

The invention discloses a non-woven fabric with a biological regulation function and a preparation method thereof. The non-woven fabric disclosed by the invention is processed by using a finishing agent prepared by using a functional combined solution, the functional combined solution comprises 25-60 wt% of oligosaccharides and 5-30 wt% of probiotic bacteria metabolites, and the functional combined solution accounts for 7-20% of the weight of the finishing agent. The preparation method comprises the following steps: 1) the preparation of the functional combined solution, namely, taking all components in proportion, adding oligosaccharides into a moderate amount of water, and stirring the obtained mixture; after the oligosaccharides are dissolved, adding probiotic bacteria metabolites into the obtained object, and stirring the obtained mixture; and adding the other components of the functional combined solution and the balance of water, and after the obtained object is mixed, adjusting the pH value of the obtained mixture to be 5-6 by using a pH regulator; 2) taking the functional combined solution and the other finishing agent components in proportion so as to prepare a finishing agent; and 3) applying the finishing agent containing the functional combined solution to the non-woven fabric, removing the redundant finishing agent, and then drying or air-drying the obtained product. The non-woven fabric disclosed by the invention has a biological regulation function, and can enhance the microbial barrier capabilities of skins and genital tracts, restrain the proliferation of pathogenic bacteria, and protect the human health.

A composition and method for treatment of viral-induced skin lesions, such as warts, are described. The composition is comprised of tea tree oil and / or derivatives from tea tree oil and one or more minerals, such as iodide and / or selenium. The composition is used to prepare medicaments for the treatment of viral-induced lesions, such as warts caused by the Molluscum contagiosum virus, human papillomavirus, and / or herpes simplex virus. The composition is applied topically to the human epidermis and / or to the genital tract as needed.

The invention discloses a temperature and pressure real-time monitoring and adjusting device used for a urogenital tract intraluminal surgery. The temperature and pressure real-time monitoring and adjusting device comprises a perfusion fluid inputting and adjusting system, a temperature and pressure monitoring system and a medical waste water and waste residue treatment system. The perfusion fluid inputting and adjusting system is used for mixing a perfusion fluid in an indoor-temperature perfusion fluid soft bag and a perfusion fluid in a preheating perfusion fluid soft bag, and inputting the mixture into an endoscope body by means of a perfusion pump; the temperature and pressure monitoring system is used for detecting temperature data and pressure data in a surgery area in real time by means of an optical-fiber-type temperature and pressure sensor, receiving a video signal collected by a video collecting system by means of an endoscope video signal receiving unit, and outputting the temperature data, the pressure data and the video signal to a display unit; the medical waste water and waste residue treatment system is used for separating medical waste water from medical waste residues, and conducting innocent treatment on the medical waste water. The temperature and pressure real-time monitoring and adjusting device is suitable for the urogenital tract intraluminal surgery, it can be guaranteed that the surgery is conducted at the proper temperature and pressure in the whole process, and operative complications are reduced or even avoided.

The current invention provides improved methods and means for the treatment of virally induced intraepithelial neoplasias of the ano-genital tract, such as HPV induced vulvar-, cervical-, vaginal-, penile- and anal intraepithelial neoplasias (VIN, CIN, VAIN, PIN and AIN). The invention provides a method of treatment of a subject suffering from an anogenital intraepithelial neoplasia comprising at least the steps of first determining whether the subject has a T-cell reactivity for viral early antigens, in particular high risk type HPV antigens; and subsequently a local treatment of the neoplasia with immune modulating compounds eliciting local inflammation if the subject scores positive for the T-cell reactivity, preferably a CD4+response against HPV early antigens. The invention also comprises methods and means to induce or further stimulate a cellular immune response against HPV antigens, prior to or during treatment with the immune modulating compound capable of eliciting a local inflammatory response.

The invention relates to a traditional Chinese medical oral liquid used for curing colibacillosis of poultries, which comprises four medicines of purslane, heartleaf houtluynia, Chinese pulsatilla and phellodendron. The combination of the four medicines has the effects of clearing away heat and toxic material, curing dysentery and improving the symptom of diarrhea caused by colon bacillus. Based on the fact that the specific physiological structure of poultries can not digest wood fibre owing to the short genital tracts, the medicaments are made into a dosage form of oral liquid which can be dispersed in drinking water and can be taken by sick poultries through drinking water, thereby being convenient for absorbing, and achieving the purpose of taking effect rapidly.

The present invention discloses a guiding object and a probe for testing the human urogenital tract pathogens, and a method for testing the human urogenital tract pathogens using the guiding object and the probe. The present invention can test three different pathogens including Neisseria gonorrhoeae, mycoplasma ureaplasma and chlamydia trachomatis in a same reaction tube simultaneously. The present invention not only can increase the early detection rate of the sexually transmitted diseases, but also can reduce the operating time of the medical personnel, lower the cost, and lighten the economic burden of the patient.

The invention relates to the technical field of compound traditional Chinese medicines for veterinary use, and particularly discloses a compound traditional Chinese medicine extract for preventing and treating livestock diarrhea syndrome, a preparation method and an application of the extract. The compound traditional Chinese medicine extract is prepared from traditional Chinese medicines such as codonopsis pilosula, rhizoma atractylodis nacrocephalae, Sichuan golden cypress, the roots of Chinese pulsatilla, common andrographis herb, pericarpium citri reticulatae and poria cocos which are mixed in a certain proportion. The medicines matched have the functions of clearing away heat and toxic materials, invigorating spleen and stomach, clearing damp, promoting diuresis and relieving diarrhea with astringents. Meanwhile, aiming at the physiological feature of livestock, particularly the characteristic of short genital tract of livestock, as traditional Chinese medicine cellulose is hard to digest and absorb, the medicine is prepared as the traditional Chinese medicine extract which can be blended and delivered in drinking water to be conveniently absorbed, so as to quickly realize the purpose of treatment. The compound traditional Chinese medicine extract has good economic and social benefits.

The invention relates to the technical field of biology, in particular to a novel lactobacillus gasseri strain for preventing and / or treating genital tract infection and / or genital tract flora disorder and application of the novel lactobacillus gasseri strain. In order to solve the technical problems of different degrees of side effects, high recurrence rate or large trauma and the like of the existing medicine for treating genital tract infection, the invention screens out a new lactobacillus gasseri TM13-16 for preventing and / or treating genital tract infection and / or genital tract flora disorder, which can generate secretions such as lactic acid, hydrogen peroxide and the like is used for inhibiting the growth of pathogenic bacteria of genital tract infection, is used for preventing and / or treatment genital tract infection diseases, particularly reducing the recurrence rate, has small toxic and side effects and lasting efficacy, and can be used as dominant lactobacillus for vagina to repair flora disorder and restore vaginal homeostasis.

The invention discloses a probiotic composite bactericide for improving microecology of an animal house and the body surface of an animal and an application method thereof. Particularly, the probiotic composite bactericide is composed of one or more than one of bacillus licheniformis, bacillus subtilis, bacillus natto, lactic acid bacteria and bifidobacteria and yeast as well as a carrier and an essence. The probiotic composite bactericide can be applied to the inner surface of the animal house and the body surface of an animal in a powder spreading or liquid spraying manner so as to remarkably improve the microecological balance of the animal house and the body surface of the animal, further reduce the incidence of digestive tract, respiratory tract and genital tract diseases and improvethe growth speed of the animal, thereby achieving a health care effect.

The invention discloses an intelligent multifunctional dairy cow / beef cattle semen deposition gun, and belongs to artificial insemination tools. A semen deposition channel is formed in a gun barrel and an inner cavity of a gun body in a through mode, a camera and a light source of a vidicon are arranged in a cavity in the front portion of the pipe barrel, a display screen is arranged on the upper wall of the gun body and is connected with the camera through a wire, a temperature control device and a vibrating device are arranged on the periphery of the semen deposition channel, a power source is arranged in a handle, and a selection switch is arranged on the inner side of the handle. The intelligent multifunctional dairy cow / beef cattle semen deposition gun has the advantages that the temperature control device enables seminal fluid to be kept at appropriate temperature and reduces damage caused to semina by low temperature; video helps an operator to accurately and quickly find out the cervical orifice so that the push-rod-type semen deposition gun can pass through the cervix uteri to enter the uterus and the semen deposition part can be determined conveniently, and meanwhile, the optimal semen deposition time can be judged according to the cervix uteri opening condition and the endometrium condition; the vibrating device enables physiological changes in the artificial insemination genital tract during artificial insemination to be closer to changes generated when animals conduct mating naturally, visual and temperature control functions are integrated and the cow conception rate can be increase easily.