40 results about "Genital tract" patented technology

The invention discloses a primer combination for identifying six genital tract pathogens and detecting drug resistance genes, a kit and application, the primer combination comprises a primer combination for identifying chlamydia trachomatis, mycoplasma genitalium, ureaplasma urealyticum, mycoplasma hominis, neisseria gonorrhoeae and trichomonas vaginalis and detecting the drug resistance genes of the six genital tract pathogens, and nucleotide sequences are shown as SEQ ID NO.1-SEQ ID NO.50. Microorganisms and related drug-resistant genes in a detection range are identified by utilizing a multiple PCR targeted three-generation sequencing method, the specificity is good, the sensitivity is high, the detection technology has important clinical significance when being applied to identification of genital tract infection pathogens, and compared with a traditional detection method, the detection flux, the coverage range and the sensitivity are higher, and detection is stable; compared with pathogenic microorganism metagenome (mNGS) detection, the method has the advantages that the detection cost is lower, and the detection sensitivity on drug-resistant genes and drug-resistant gene mutation is higher.

The invention relates to lactobacillus gasseri FMTA1121E with an effect of regulating a vaginal micro-ecological environment and application of the lactobacillus gasseri FMTA1121E. The lactobacillus gasseri FMTA1121E is classified and named as lactobacillus gasseri, and the preservation number of the lactobacillus gasseri FMTA1121E is CGMCC No.34962. The lactobacillus gasseri FMTA1121E can be metabolized to generate beneficial components such as lactic acid, gamma-aminobutyric acid and hydrogen peroxide so as to regulate the genital tract environment and improve the health degree; and the bacillus subtilis has excellent bacteriostasis and sterilization effects on various common vaginal pathogenic bacteria such as escherichia coli, staphylococcus aureus, gardnerella vaginalis, candida albicans, neisseria gonorrhoeae and the like. Therefore, the lactobacillus gasseri FMTA1121E strain can be applied to preparation of preparations for preventing and treating related genital tract diseases such as vaginitis.

The application provides a primer probe composition and application thereof in detection of urogenital tract pathogens, and relates to the technical field of biology. The primer probe composition comprises a chlamydia trachomatis primer probe pair with sequences shown in SEQ ID NO:1-6; a gonococcus primer probe pair with sequences shown in SEQ ID NO:7-9; and a mycoplasma genitalium primer probe pair with sequences shown in SEQ ID NO:10-12. The primer probe pairs in the primer probe composition do not have significant cross interference, the lower limit of detection can be as low as 20 copies / reaction, 200 copies / mL, and the problem that the lower limit of detection of the urogenital tract pathogens in the prior art needs to be reduced is solved.

The invention discloses a primer probe group and a kit for joint detection of mycoplasma genitalium, ureaplasma urealyticum and chlamydia trachomatis, and belongs to the technical field of molecular biological detection. The primer probe group comprises a primer probe group A for directly detecting a mycoplasma genitalium mgpB gene, a primer probe group B for directly detecting a ureaplasma urealyticum ureB gene and a primer probe group C for directly detecting a chlamydia trachomatis ompA gene; the kit comprises a PCR (Polymerase Chain Reaction) reaction solution and the primer probe group. Nucleic acid extraction is not needed, the detection cost is greatly reduced, the experiment time is shortened, meanwhile, the specificity and accuracy are still guaranteed, meanwhile, the sensitivity is improved, and the method has wide application prospects in the fields of non-gonococcal genital tract infection main pathogen detection, infertility and prenatal and postnatal care screening and the like. And the kit has important significance on clinical diagnosis, early treatment and prevention of diseases, prevalence and the like.

In an aspect, a method for applying beta-alanine to a tissue surface is described. The method may comprise applying a composition comprising from about 0.01 % w / w to about 5.0 % w / w beta-alanine to a tissue surface. The beta-alanine may comprise between about 0.08 % w / w to about 2 % w / w. The tissue surface may be suffering from a condition. The tissue surface may be from the group consisting of epidermis, mucosal membrane, respiratory tract lining, urinary tract lining, and reproductive tract lining. In another aspect a composition may comprise from about 0.01 % w / w to about 5.0 % w / w beta-alanine; water; an emulsifying component; and a fat. The fat may be an emollient or a moisturizing component.

The invention belongs to the technical field of medical supplies, and particularly relates to an adjustable cervix uteri multi-point micro-injection device which comprises a guide cylinder, an adjusting mechanism is mounted in the guide cylinder, and an injection needle is mounted on the side, extending into a human body, of the adjusting mechanism; the other side of the adjusting mechanism is connected with the carry control mechanism, the rotation control mechanism and the deflection control mechanism through a first connecting rod, a second connecting rod and a third connecting rod. The other side of the adjusting mechanism is further connected with a connecting hose, and the other end of the connecting hose is connected with an injector. Wherein the adjusting mechanism comprises a carry mechanism, a rotating mechanism and a deflection mechanism, the situation that the device pierces other parts of the genital tract of a patient to cause injury before reaching the cervical lesion part can be avoided, and the injection needle can be deflected towards different parts through the adjusting mechanism; according to the device, the injection needle can accurately pierce a diseased region for injection under the condition that the adjustment range in the genital tract of a patient is minimum.

The invention belongs to the technical field of medicines, and discloses a gynecological bacteriostatic lotion and a preparation method and application thereof.The lotion is prepared from extracts of traditional Chinese medicinal materials such as radix sophorae flavescentis, cortex phellodendri, coptis chinensis, scutellaria baicalensis, rhizoma smilacis glabrae, cortex dictamni, fructus cnidii, areca nuts, cortex meliae, golden larch bark, lithospermum erythrorhizon, lavender, rheum officinale and honeysuckle as main raw materials, and parachloroxylenol, salicylic acid and borneol as auxiliary materials. A compound preparation with multiple effects is formed through scientific proportioning and a preparation process, the product can effectively inhibit common pathogenic bacteria such as Candida albicans, Staphylococcus aureus and Escherichia coli, shows a broad-spectrum and efficient antibacterial effect, and is small in irritation, high in safety to vaginal mucosa and genital tract environment and free of toxic and side effects. The product can maintain local micro-ecological balance and reduce inflammation recurrence while cleaning and nursing, has the advantages of long-term conditioning of a traditional Chinese medicine compound and rapid sterilization of western medicine components, and is suitable for clinical popularization and application.

The invention discloses a vaginal balance peptide derived from a vaginal microbiome and application thereof, the vaginal balance peptide can selectively inhibit lower genital tract infection pathogens, has no inhibition effect on vaginal probiotic lactobacillus, and has: (a) an amino acid sequence as shown in SEQ ID NO.1; or (b) an amino acid sequence which is obtained by substitution, deletion and / or addition of one or more amino acids of the amino acid sequence as shown in SEQ ID NO.1 and has the same function as that of SEQ ID NO.1; or (c) an amino acid sequence which has at least 85% homology with the amino acid sequence shown in SEQ ID NO.1 and has the same function as the amino acid sequence shown in SEQ ID NO.1. The balance peptide is efficient in antibiosis, specifically inhibits growth of lower genital tract infection pathogens, and has a remarkable inhibiting effect on gardnerella vaginalis, group B streptococcus, candida albicans and the like; the selectivity is high, the effect of inhibiting growth of various common vaginal probiotics lactobacillus is avoided, and the effect of balancing micro-ecology is achieved; the safety and the treatment effect are good.

The utility model relates to the technical field of animal husbandry instruments, in particular to a genital tract effusion collecting device for livestock in animal husbandry. The genital tract effusion collection device comprises an extraction part, a suction catheter used for stretching into the effusion position and a support assembly. The extraction part is provided with a storage cylinder used for containing genital tract effusion. And a piston is arranged in the storage cylinder. A connecting column is arranged at the bottom of the storage cylinder. And a suction channel is arranged in the connecting column. The side wall of the connecting column is sleeved with the suction catheter. The suction catheter is connected with the storage cylinder through the suction channel. The support assembly comprises a lantern ring and supporting legs. And the lantern ring is mounted on the side wall of the storage barrel. And the plurality of supporting legs are circularly arranged along the axis of the lantern ring. The supporting legs are connected with the side wall of the lantern ring. According to the genital tract effusion collecting device for the livestock in the animal husbandry, collection of the genital tract effusion of the livestock is achieved, the safety is improved, the difficulty of effusion extraction is reduced, and the collecting efficiency is improved.

The application discloses a primer and probe for urogenital tract microorganism detection, a kit and a use method of the kit. The primer and probe for urogenital tract microorganism detection, the kit and the use method of the kit can simultaneously detect chlamydia trachomatis, ureaplasma urealyticum and gonococcus. By using real-time fluorescent PCR amplification technology, only one nucleic acid extraction and one-step PCR detection reaction are needed. The use method of the kit is rapid, simple, specific, high in sensitivity and wide in detection range. The sensitivity can reach 400 copies / ml, the detection range is 400 copies / ml to 4.00E+09 copies / ml, and the non-chlamydia trachomatis, ureaplasma urealyticum and gonococcus pathogenic microorganisms cannot be detected, so the problem of false positive is not prone to occur.

A microbiome modulating composition and a method for producing the microbiome modulating composition are described herein. The method comprises preparing a culture from at least two of any Lactobacillus spp. bacteria, Limosilactobacillus spp. bacteria, or combinations thereof, passaging the culture on a glycogen carbon source to form a postbiotic ferment of the at least two of any Lactobacillus spp. bacteria, Limosilactobacillus spp. bacteria, or combinations thereof, and adding the postbiotic ferment to a carrier. Further disclosed is a method for treating microbial dysbiosis of an urogenital area or a skin area of a user, the method comprising applying the microbiome modulating composition to an urogenital or a skin area of a user. The disclosed methods and microbiome modulating compositions help promote the growth of healthy Lactobacillus spp. bacteria to prevent dysbiosis and other related conditions and infections.

This invention provides a composition for detecting genital tract pathogens, its preparation method, and its application, belonging to the field of nucleic acid or microbial assays or tests. The composition provided by this invention includes a forward primer, a reverse primer, and a probe targeting seven genital tract pathogens. The forward and reverse primers are used to amplify the target DNA. A blocking group is added between the i-th nucleotide and the (i+1)-th nucleotide from the 3' end of the reverse primer, where 4 ≤ i ≤ 8. The probe is labeled with a fluorescent group and a second quenching group at both ends, and a first quenching group in the middle. A portion of the probe's sequence is identical to a portion of the reverse primer's sequence. The composition provided by this invention enables multiplex qualitative detection of seven genital tract pathogens: Neisseria gonorrhoeae, Chlamydia trachomatis, Ureaplasma urealyticum, Ureaplasma microsporum, Mycoplasma hominis, Mycoplasma genitalium, and herpes simplex virus type 2.

The application discloses a multiplex detection kit for urogenital tract infection pathogens, which can simultaneously and efficiently and accurately detect at least two of four pathogens, CT, MG, MH and NG, the minimum detection limit of the four pathogens is 400 copies / mL, and the kit is perfectly compatible with three samples, namely, non-invasive urine, male urethral secretions and female cervical secretions, and has a wide application range.

Lower genital tract access devices, methods, systems and kits Disclosed are devices, methods, systems and kits for obtaining biological tissue samples. Also disclosed are hysteroscopy or colposcopy devices that eliminate the need for a separate speculum and that improves patient comfort.

The present invention relates to a composition, especially to a pharmaceutical composition, for intravesical application into the urinary bladder, preferably via instillation by means of a catheterizing device), particularly for use in the prophylactic and / or curative treatment of diseases and / or dysfunctions of the urogenital tract, preferably diseases and / or dysfunctions of the urinary bladder.

Lower genital tract access devices, methods, systems and kits Disclosed are devices, methods, systems and kits for obtaining biological tissue samples. Also disclosed are hysteroscopy or colposcopy devices that eliminate the need for a separate speculum and that improves patient comfort.

The invention discloses application of double-cavity probiotic intervention in colon cancer chemotherapy and intestinal tract and genital tract flora, and relates to the technical field of biological medicine. The bifidobacterium longum subsp. Longum NCU-05 is preserved in the China General Microbiological Culture Collection Center (CGMCC) on January 18, 2023, and the preservation number is CGMCC NO.26492; the lactobacillus crispatus NCU-28 is preserved in the China General Microbiological Culture Collection Center on July 22, 2024, and the preservation number of the lactobacillus crispatus NCU-28 is CGMCC NO.31387. The lactobacillus crispatus NCU-28 has been preserved in the China General Microbiological Culture Collection Center. The traditional Chinese medicine composition has the beneficial effects that intestinal tract and genital tract flora imbalance after colon cancer chemotherapy can be improved, and the traditional Chinese medicine composition can be used as an auxiliary medicine for treating colon cancer. The bifidobacterium longum subsp. Longum and the lactobacillus crispatus are administered through a bidirectional crosstalk cavity of intestinal-vaginal microbiota in a combined medication form, so that the intestinal tract and genital tract dysbacteriosis after colon cancer chemotherapy is effectively improved.

This invention provides a dual-segment, dual-color pH comparison catheter for clinical identification of premature rupture of membranes, belonging to the field of medical catheter technology. It includes a main catheter tube with a urine segment pH membrane and an amniotic fluid segment pH membrane sequentially arranged along the axial direction on the anterior outer wall of the main tube. The urine segment pH membrane has a color development range of pH 5.5-6.5, and its color change is a continuous gradient from yellow to green. This invention achieves zero-sampling detection under sterile conditions, highly integrating pH identification function into routine catheterization procedures. The pH value of urine and any potentially mixed amniotic fluid is simultaneously detected upon catheter insertion into the bladder, without the need for vaginal speculum, sampling swabs, or any form of secondary sterile opening. This design completely blocks the path of exogenous bacteria into the maternal reproductive tract at a physical level, thereby fundamentally and effectively reducing the incidence of clinically common chorioamnionitis and urinary tract infections, and improving perinatal medical safety and quality.

This invention relates to the field of in vitro diagnostics, and particularly to a combined diagnostic kit for prostate diseases. The invention provides reagents including pH, peroxidase, elastase, lecithin bodies, citric acid, zinc, and acid phosphatase under mild reaction conditions, enabling rapid differentiation of inflammatory and non-inflammatory prostatitis, benign prostatic hyperplasia, and non-prostatic genital tract infections using a single test card. Through extensive experimentation, this invention has developed a one-step reaction scheme suitable for the dry chemical determination of acid phosphatase and lecithin bodies in seminal plasma. This method eliminates the need for a stop solution, achieving a one-step reaction under mild conditions that will not cause damage to operators or fully automated instruments. The samples used are seminal plasma or semen, allowing for large sample volumes and easy acquisition, significantly improving diagnostic efficiency for doctors and patient comfort.

The invention discloses a control method for a liquid path system of a genital tract secretion analyzer. The control method comprises the following steps: 1, confirming the pure water amount of a water feeding unit, the reagent amount in a first container and the waste liquid amount of a waste liquid unit; then filling a water feeding unit and a reagent, and quantitatively adding a sample diluent into the sample by utilizing a reagent filling unit to obtain a diluted sample; the sample filling unit is used for taking a TIP head and quantitatively sucking and diluting a sample into a board card and a reaction container for several times; quantitatively filling a reaction reagent into the board card by using a reagent filling unit, and carrying out dry chemical detection; a reagent filling unit is used for quantitatively filling staining fluid into the reaction container, and the staining fluid is dropwise added to a slide for morphological detection after staining. The sample filling unit adopts a sample pump for direct filling, and the reagent filling unit adopts positive pressure filling, so that only one TIP head is needed in the detection process of each sample, on one hand, the TIP head material consumption is remarkably reduced, on the other hand, the action logic of sample pretreatment is simplified, and the detection efficiency of an instrument is improved.

The invention discloses a genital tract dilation device for early and middle stage pregnancy termination, relates to the technical field of genital tract dilation instruments, and provides the following scheme that the genital tract dilation device comprises a valve type cervical orifice dilator and a pair of genital tract dilation forceps, and the valve type cervical orifice dilator is clamped at the tip position of the front side of the genital tract dilation forceps; the valve type cervical orifice dilator comprises 6-8 arc-shaped side plates which are arranged in an annular array. According to the technical scheme, the expansion control mechanisms are arranged on the forceps arms of the oval forceps, and by means of an arc-shaped strip and a rectangular clamping groove in the left forceps arm, after the two forceps arms are expanded by a certain angle, a rectangular coupling clamping block in the right forceps arm is pushed forwards to be clamped into the rectangular clamping groove in the arc-shaped strip, and then the forceps arms are expanded by a certain angle. The opening and closing angle of the pliers is stably and firmly limited; in addition, by arranging the valve type cervical orifice dilator, the cervical orifice is dilated in multiple directions in a pneumatic mode, amniotic fluid can be helped to flow out when the pregnancy is terminated, and a space for clamping a pregnancy object can also be provided.

The invention discloses a phycocyanin hydrogel capable of resisting endometritis and promoting vaginal flora regulation as well as a preparation method and application of the phycocyanin hydrogel. The preparation method comprises the following steps: a, adding a polylactic acid high-molecular polymer material into a sterile solvent, and performing low-temperature stirring reaction to obtain a hydrogel solution; and b, adding phycocyanin powder into the hydrogel solution prepared in the step a, and carrying out low-temperature stirring reaction to obtain the phycocyanin hydrogel. The hydrogel is phycocyanin hydrogel formed by wrapping natural phycocyanin with a polylactic acid derivative, accurate delivery in the genital tract can be achieved, and meanwhile, the anti-inflammatory and anti-apoptosis effects of phycocyanin can be fully exerted by slow release of the phycocyanin in the hydrogel; and the hydrogel can maintain an acidic environment in the vagina and regulate vaginal flora. The phycocyanin hydrogel disclosed by the invention is expected to bring a new treatment means for patients with endometritis and vaginal dysbacteriosis.

According to the kit for rapidly and quantitatively detecting the microorganisms in the genital tract and the micro-ecological evaluation method thereof provided by the invention, quantitative detection of nearly 50 different types and different types of microorganisms in the genital tract can be realized by designing a primer probe combination and improving amplification reaction conditions; according to the method, vaginal lactobacillus groups, pathogenic genital tract microorganisms, sexually transmitted microorganisms and cervix uteri microorganisms are covered, 32 kinds of microorganisms can be distinguished, main microorganisms in the genital tract are comprehensively covered, meanwhile, a corresponding micro-ecological evaluation method is designed in a matched mode, various vaginitis, sexually transmitted diseases and HPV are rapidly diagnosed, and the method has the advantages of being simple in operation, convenient to operate and high in practicability. And a basis is provided for clinical treatment and prognosis of genital tract infection.

This invention relates to the field of molecular detection technology, and particularly to the application of Trichomonas vaginalis target genes, primer-probe combinations, and kits. This invention provides a novel application of Trichomonas vaginalis target genes in the detection of Trichomonas vaginalis, and its specific primer-probe design. The primers and probes described in this invention have high specificity, exhibiting no cross-reactivity with closely related species and common pathogens of the urogenital tract. They also possess advantages such as rapid detection speed and high sensitivity, achieving detection results within 1 hour using real-time fluorescence PCR, and can detect as few as a single Trichomonas vaginalis. This invention also provides a kit with high detection sensitivity, enabling the detection of Trichomonas vaginalis even in urine samples. It can also be combined with primers and probes for Mycoplasma genitalium and / or Mycoplasma hominis to form primer-probe combinations.

The present invention discloses a Lactiplantibacillus plantarum and its application. The Lactiplantibacillus plantarum is named strain LSA-410, which was deposited at the Guangdong Provincial Culture Collection Center of Microorganisms on August 18, 2022, with the deposit number GDMCC No. 62712. The strain LSA-410 has a strong lactic acid production ability, can effectively inhibit the growth of common pathogenic bacteria in the urogenital tract (such as Gardnerella vaginalis, uropathogenic Escherichia coli, etc.), can strongly adhere to cervical epithelium (Hela cells) and human bladder transitional cell carcinoma cells (T24 cells), is non-toxic, non-pathogenic, safe and reliable. Based on these advantages, the strain LSA-410 can be used for the research and development of vaginal microecological preparations for the treatment / prevention of urogenital diseases, and reduce the infection and recurrence rates of urogenital diseases.

This application belongs to the field of microbial technology, specifically disclosing the application of *Lactobacillus fermentum* BLF03 in anti-Candida activity. *Lactobacillus fermentum* BLF03 was deposited on November 6, 2025, at the China General Microbiological Culture Collection Center (CGMCC) with accession number CGMCC No. 36521. This application proposes a *Lactobacillus fermentum* BLF03 strain resistant to *Candida albicans* and *Candida krusei*, which can significantly inhibit the growth, reproduction, and hyphal transformation of *Candida albicans* and *Candida krusei* at the in vivo level, alleviate Candida-induced infection symptoms, reduce the expression level of the inflammatory marker procalcitonin (PCT) after Candida infection, improve the inflammatory stress response induced by infection, and has a significant protective effect against tissue damage caused by Candida invasion. It also has targeted preventive and adjunctive therapeutic effects on Candida infections in the urogenital tract and other sites, providing a new, safe, and highly effective strain for anti-Candida products.

The invention discloses a gel composition for repairing female genital tracts as well as a preparation process and application of the gel composition. The composition comprises three functional core systems: a polysaccharide-enzyme compound A which is formed by self-assembly of superoxide dismutase and oxidative degradation modified aloe polysaccharide and has antioxidant and microenvironment regulation functions; a metal ion-polysaccharide slow-release antibacterial body B formed by coordination of zinc ions and low-molecular-weight chitosan provides instant and long-acting antibacterial protection; the plant polyphenol-protein tissue repair body C is formed by non-covalent binding of epigallocatechin gallate and hydrolyzed collagen, and tissue regeneration and functional reconstruction are promoted. The three components are compounded according to a mass ratio of (1-2): (0.5-1): (2-4), and are integrated with a carbomer matrix to form stable gel. The invention further provides a specific preparation process and a synergistic effect mechanism of all the components. The gel has good stability, biocompatibility and repairing efficiency, and is suitable for treating or improving female genital tract mucosa lesion, inflammation or flora imbalance.

The invention focuses on a quantum dot microfluidic immunodetection chip and a kit for detecting female genital tract chlamydia trachomatis. The chip comprises a substrate and a cover plate, a sample loading area, a pretreatment area, a reaction area, a detection area and a waste liquid area which are sequentially communicated are formed on the substrate, a plurality of layers of polyelectrolyte-nano magnetic bead self-assembled films are formed in the pretreatment area, an electromagnetic coil is embedded in the cover plate and is aligned with the center of the pretreatment area, and the electromagnetic coil is embedded in the cover plate. A quantum dot anti-MOMP antibody is fixed on the inner wall of a channel of the reaction area, and a photonic crystal microcavity is formed in the detection area. The kit comprises the chip. According to the chip, rapid, high-sensitivity and high-specificity detection of CT is realized through three core innovative designs of a fluorescence enhancement region, an active in-situ pretreatment and enrichment structure and a space-time resolution antibody arrangement structure; meanwhile, a kit containing the chip is provided, the detection convenience and the automation level are further improved, and the application requirements of basic medical institutions are met.

The invention provides a composition with vaginal antibacterial, anti-inflammatory and repairing effects and an external preparation comprising the composition. The composition comprises carbomer, glycosaminoglycan quaternary ammonium salt and recombinant III-type collagen. The invention also provides a gel with vaginal antibacterial, anti-inflammatory and repairing effects and a preparation method thereof. Carbomer and glycosaminoglycan quaternary ammonium salt are adopted, have synergistic antibacterial and anti-inflammatory effects, are matched with the recombinant III-type collagen, can keep the vagina moisturized and lubricated and keep the vagina moist and compact, have a repairing effect on the vagina, can synergistically enhance the mucous membrane elasticity and repairing capacity and improve the wound healing capacity, and can be used for repairing the vagina. A strong repairing effect is achieved on a genital tract wound surface or an erosion surface; the invention further provides a gel containing the composition with the vaginal antibacterial, anti-inflammatory and repairing effects, and the quality of a gel product is ensured by adopting a double preservative system of sodium methyl p-hydroxybenzoate and sodium propyl p-hydroxybenzoate.