The invention discloses a controllable
drug release
balloon catheter for treating urethrostenosis and a preparation method of the controllable
drug release
balloon catheter, and belongs to the technical field of medication for urinary diseases, two
layers of coatings with different components are sprayed on the surface of a
balloon, the coatings comprise a
drug-loaded microcapsule complex
coating and a
quaternary ammonium salt modified
silicon dioxide
coating, and the drug-loaded microcapsule complex
coating and the
quaternary ammonium salt modified
silicon dioxide coating are compounded through cooperation of the two coatings. The long-acting effect of the
medicine can be guaranteed, the
medicine is not prone to being washed away by
blood flow and losing
efficacy, the
lubricity is good, the
urethra of a patient is not prone to being damaged, and the local inhibition effect on urethrostenosis
inflammation of the patient is achieved; the drug-loaded microcapsule complex coating on the inner layer has a certain swelling effect, the drug-loaded microcapsule complex coating absorbs water to swell in the
urethra, the
radial pressure generated by swelling can stretch the outer layer, gaps among
silicon dioxide particles are enlarged, disulfide bonds are fully exposed, the fully exposed disulfide bonds are more easily in contact with acid metabolites and reducing agents at the
urethritis part, and therefore the
urethritis treatment effect is improved. The
disulfide bond breaking efficiency is improved, and free release of
quaternary ammonium salt is accelerated.