128 results about "Mucosal lesion" patented technology

The invention relates to a preparation and using method of medical biocompatible stent material. The medical biocompatible stent material is prepared by applying the small intestine submucosal and the tendon tissue of people or animals as the raw materials. The invention has good biocompatibility, appropriate porosity and mechanical strength and stable spatial structure, and the invention contains various growth factors to induce the tissue for regeneration and reconstruction, thereby improving the success rate of the repair of the various tissue defects and the reconstruction of tissue structures, therefore, the invention is an ideal tissue engineering material. The medical biocompatible stent material which is provided by the invention is applicable to the preparation of various tissue engineering equipments and the application in the repair of various tissue defects and injuries, including skin, blood vessels, nerves, tendons, bones, cartilages, abdominal walls, urinary tracts, oral mucosa and so on, and the invention can be used in the treatment of trauma, abdominal external hernia, anal fistula, rectovaginal fistula, rectum anterior protrusion, bone and cartilage defects, vascular injuries, nerve injuries, tendon injuries, oral mucosal injuries, relaxed pelvic floor, urinary tract injuries and other diseases.

The invention relates to the field of tobaccos, and particularly relates to a gastric mucosa protected mouth-holding type smokeless tobacco product and a preparing method thereof. The gastric mucosa protected mouth-holding type smokeless tobacco product comprises, by weight, 15-60 parts of a tobacco material, 0.1-10 parts of a gastric mucosa protected traditional Chinese medicine agent, 0.5-5 parts of a saline taste agent, 0-20 parts of a sweetening agent, 0.5-6 parts of an acidity regulator, 0.5-15 parts of a natural flavoring agent, 1-5 parts of a humectant, 1-10 parts of polybutene, 0.005-1 part of an antioxidant, 0.005-0.5 part of a corrosion remover and 40-60 parts of moisture. The mouth-holding type smokeless tobacco product is comfortable in taste and appropriate in strength; the problems of the discomfort stomach, gastric mucosal lesion and the like caused by intake of a large amount of nicotine in the smoking process of an existing mouth-holding type smokeless tobacco product are solved, and the effect of protecting the gastric mucosa is achieved.

The present invention belongs to the field of biotechnology and particularly relates to a composition for the auxiliary protection of gastric mucosa and / or the remission of gastrectasia and a microecological preparation thereof. The composition for the auxiliary protection of gastric mucosa and / or the remission of gastrectasia is prepared through the synergistic combination of traditional Chinese medicines homologous in medicine and food, and probiotics. The traditional Chinese medicines homologous in medicine and food are composed of hericium erinaceus and poria cocos. The microecological preparation is prepared by the above composition and preparation auxiliary components. According to the technical scheme of the invention, the composition is prepared through the synergistic combination of traditional Chinese medicines homologous in medicine and food, and probiotics, so that the composition can well protect the gastric mucosal lesion and / or the gastrectasia. Meanwhile, the composition can adjust the balance of intestinal flora and improve the resistance. The traditional Chinese medicines homologous in medicine and food, and the probiotics play effects synergistically and promote each other, thus entirely regulating the body constitution and maintaining the normal health status.

The present invention relates to novel compounds of 2-propene-1-one series, of general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them, wherein R5, R6, Q and Y are as defined in the specification. The present invention also relates to a process for preparing such compounds, compositions containing such compounds, and use of such compound and composition in medicine. The compounds of the general formula (I) induce HSP-70 and are useful for the treatment of diseases accompanying pathological stress in a living mammalian organism, including a human being, such as stroke, myocardial infarction, inflammatory disorder, hepatotoxicity, sepsis, diseases of viral origin, allograft rejection, tumourous diseases, gastric mucosal damage, brain haemorrhage, endothelial dysfunctions, diabetic complications, neuro-degenerative diseases, post-traumatic neuronal damage, acute renal failure, glaucoma and aging related skin degeneration.

Inhibiting gastric proton pump in a mammal is accomplished by the use of a compound of formula (1) wherein the variables have the meaning given in the present description. A preferred compound of formula (2) is this treatment ameliorates, diminishes, actively treats, reverses or prevents any injury, damage or lesions of gastric mucosa, e.g. gastric mucosal lesions and ulceration.

The invention provides high-adhesion bi-component self-crosslinking digestive tract injury mucosa protection glue and application thereof. The high-adhesion bi-component self-crosslinking digestive tract injury mucosa protection glue comprises an aldehyde group-containing high polymer biological material and an amino group-containing high polymer biological material. The two components are mixed through a double-cavity injector and then injected to the surface of a digestive tract injury mucosa through an endoscope, aldehyde groups and amino groups in the two components are crosslinked to forma colloid membrane, the aldehyde group-containing high polymer biological material is combined with protein amino groups exposed on a wound surface and firmly adheres to the wound surface, the stimulation effect of intestinal digestive juice on the digestive tract injury mucosa is avoided, and healing of the wound surface is promoted. Animal tests show that the high-adhesion bi-component self-crosslinking digestive tract injury mucosa protection glue can obviously promote repair of the injury mucosa, and therefore the high-adhesion bi-component self-crosslinking digestive tract injury mucosaprotection glue has the effects of promoting healing and protecting esophagus, stomach and intestinal tract mucosa injuries and skin wound surfaces.

The present invention provides therapeutic compositions comprising extracts of the plant species Echinacea purpurea and Sambucus nigra and the extract(s) of at least one further plant selected from the group consisting of Hypericum perforatum, Commiphora molmol and Centella asiatica. The compositions of the invention are of particular utility in the management of inflammatory mucosal diseases of both viral and non-viral origin.

The present invention discloses a Chinese medicine compound for gastric mucosa protection and the preparation method. The plantaginis and the dandelion are taken as the raw materials in the compound, which are mixed with the excipient into an oral preparation after extraction with the ethanol subsiding method or the alcohol extraction and decompression of the recycling recycling. The present invention has synergistic interaction function. Single application of the plantaginis and the dandelion both have gastric mucosa protection function, which have a synergistic interaction function after combination and the treatment effect can increase dramatically. The technique process is simple and convenient. The active part can be maintained as much as possible. The present invention has a good protection and treatment function for the acute gastric mucosa injury, the chronic gastric mucosa injury and the chronic atrophic gastritis.

The invention provides a functional food facilitating the recovery of gastric mucosal lesion. The functional food comprises the following components of wall-breaking pollen, polysaccharide, oligopeptide, fructo-oligosaccharide and maltitol. According to the functional food disclosed by the invention, medicinal and edible foods and new resource foods are preferably selected, and diet and health preservation are organically combined through a modern enzymatic biotechnology, so that gastric ulcer is recuperated, prevented and resisted, and the functional food has the unique advantage of integrating the treble efficacies of dietetic therapy, prevention and recuperation into a whole.

The invention discloses a composition of cockroaches and pseudo-ginseng, and application thereof. The composition is prepared from cockroach extract and pseudo-ginseng extract according to a ratio of1: 3. A preparation method for the cockroach extract comprises the following steps: subjecting cockroaches to reflux extraction with an 80% ethanol solvent for three times, wherein each extraction lasts for 1 h; then removing oil and carrying out filtering; and then successively carrying out pressure-reduced concentration, drying and crushing so as to obtain the cockroach extract. A preparation method for the pseudo-ginseng extract comprises the following steps: adding 70% ethanol into the medicinal material pseudo-ginseng, carrying out extraction for 2 h, and then carrying out cooling; carrying out filtering and recovering ethanol from the obtained filtrate; and then successively carrying out pressure-reduced concentration, drying and crushing so as to obtain the pseudo-ginseng extract. The composition has substantial effect when applied to prevention and treatment of gastric mucosal lesions, especially gastric mucosal lesions caused by aspirin; and the composition has obvious effectcompared with separate usage of the cockroach extract and the pseudo-ginseng extract.

The invention relates to the fields of medical treatment evaluation and detection technology, and in particular relates to a method for preparing an intestinal mucosa injury animal model and applications of the prepared intestinal mucosa injury animal model. According to the scheme, the medicine L-MSO having good water solubility and realizing convenient and simple gavaging operation is adopted, the mouse intestinal mucosa injury is conveniently and stably induced, and meanwhile, the corresponding tissue pathological change and inflammatory factor change are caused. For the preparation method provided by the invention, the intestinal mucosa injury animal model is prepared from the metabolism injury direction obviously different from the molding direction of immune injury inducing in the prior art, particularly, the low-concentration L-MSO is adopted for preparing the common injured model, wherein the intestinal mucosa of the laboratory mouse has the mild-moderate injury, the high-concentration L-MSO is adopted for preparing the seriously injured model, wherein the intestinal mucosa of the laboratory mouse has the severe injury; the prepared intestinal mucosa injury model has the significant values for the research and practice of inflammatory bowel diseases.

The invention relates to a method for analyzing molecular typing based on gastric mucosal lesion proteomics, different gastric mucosal lesion proteomics molecular subtype characteristics and correlation between the molecular typing and the subtype characteristics and the gastric mucosal lesion progress. A protein marker database related to gastric cancer and gastric mucosal lesion progress is established by calculating the relationship between protein expression and gastric mucosal tissue pathological state, proteome molecular subtype and gastric mucosal lesion progress, and a gastric mucosallesion sample disease progression risk scoring system is established. According to the invention, a molecular epidemiological research means is combined with bioinformatics analysis and machine learning, microscopic and macroscopic gastric cancer cause risk factors are integrated, a gastric mucosal lesion molecular typing framework and a progress risk prediction model are established, and a foundation is laid for finally constructing a comprehensive and systematic gastric cancer prevention strategy.

The invention discloses lactobacillus fermentum capable of regulating intestinal tract Claudin-1 and application of the lactobacillus fermentum, and belongs to the technical field of microorganisms. According to the lactobacillus fermentum CCFM1058 provided by the invention, the barrier function of intestinal mucosa can be effectively improved; compared with a colitis group, the lactobacillus fermentum CCFM1058 has the advantages that the expression level of the Claudin-1 protein gene is increased by nearly two times, and the colonic mucosal lesion is repaired. The level of lactobacillus fermentum CCFM1058 for improving the Claudin-1 is obviously better than that of a lactobacillus fermentum strain CECT5716 of a model strain. Therefore, the lactobacillus fermentum CCFM1058 with the function of regulating the Claudin-1 to protect the intestinal mucosa barrier has a wide application prospect in the fields of foods and microecological preparations.

Provided is a ganoderma lucidum spore oil with a protective effect on gastric mucosa. The ganoderma lucidum spore oil is obtained by extracting ganoderma lucidum spore powder through a supercritical carbon dioxide double extraction technology, the oleic acid value of the ganoderma lucidum spore oil is smaller than or equal to 2 KOH (mg / g), and the peroxide value is smaller than or equal to 0.1%. Afirst extraction uses a supercritical carbon dioxide extraction technology to extract the ganoderma lucidum spore powder to obtain ganoderma lucidum spore crude oil, and a second extraction uses theganoderma lucidum spore crude oil extracted by the first extraction and then uses the supercritical carbon dioxide extraction technology to purify the ganoderma lucidum spore crude oil to obtain the ganoderma lucidum spore oil. The ganoderma lucidum spore oil has the effect of protecting the gastric mucosa, can significantly reduce gastric mucosal lesion ulcer and bleeding caused by ethanol, inflammatory pain and other gastric mucosal lesion agents, and delays the occurrence time of an ethanol effect. The ganoderma lucidum spore oil is stable in quality, when the ganoderma lucidum spore oil isused as a raw material of food, health-care food or medicine, a product has the effects of protecting the gastric mucosa and preventing and treating gastric mucosa injury, ulcer and bleeding, and supercritical double extraction, purification and separation can be carried out on line.

The present invention provides a Chinese medicine compound for curing gastric and duodenal ulcer, made from the raw materials with weight portions such as yanhusuo, dandelion, nutgrass flastedge, mastic gum, alum and liquorice, and a preparation method of capsule, tablet, pill, granule, powder, dropping pill and oral liquid of the compound. The present invention has the functions of obvious sterilization and bacteriostasis on helicobacter pylori, reduction of gastric juice amount, gastric free acid and total acidity, and pepsin output, as well as pain alleviating and inflammation resisting, so the present invention has the functions of inhibiting stress type, ostium pyloricum deligation, acetic acid and ethanol ulcer, as well as pain alleviating and inflammation resisting. In addition, the present invention can reduce the stimulus factors of chronic gastricism, gastric ulcer and gastratrophia lesions, improve the symptoms of patients with gastric ulcer and play a promoting role in repairing and improving gastric mucosal lesion.

The invention discloses an eatable drug having the function of assisting treatment of gastric mucosal lesion and a preparation method thereof and relates to the technical field of eatable drugs. The eatable drug contains endothelium corneum gigeriae galli, pseudo-ginseng, cardamom seeds, radix polygonati officinalis, angelica dahurica, cuttlebone, radix paeoniae alba, dried tangerine or orange peels, fried rice straw, roasted malt, seaweed polysaccharides and yam flour. The endothelium corneum gigeriae galli, the fried rice straw and the roasted malt in the eatable drug have digestion helping and stomach invigorating effects; the cardamom seeds, the dried tangerine or orange peels and the yam flour have the effect of tonifying the spleen and nourishing the stomach; the pseudo-ginseng, the angelica dahurica and the cuttlebone have hyperacidity relieving and pain relieving effects; the radix polygonati officinalis has the effects of nourishing Yin and moistening dryness; the radix paeoniae alba has the effects of calming the liver and relieving the pain; the seaweed polysaccharides can enhance immunity and can be antibacterial and anti-inflammatory. After fermentation, the seaweed polysaccharides and the above medicinal materials (foods) are compatible, so that the eatable drug has the effects of treating stomach cold, stomach pain, gastrectasia, gastritis, gastric ulcers, gastric mucosa shedding and other stomach diseases.

The invention relates to a device for examining rectum-anal canal mucosal lesion tissues. The device comprises an image acquisition portion, an image processing portion, an image reconstruction portion and an image display portion. The image acquisition portion is used for acquiring rectum-anal canal mucosal images; the image processing portion is used for processing image data acquired by the image acquisition portion; the image reconstruction portion is used for reconstruction of the rectum-anal canal mucosal images shot by the image acquisition portion; the image display portion is used for displaying the images generated by the image reconstruction portion. The device has advantages that the contrast ratio of surface blood capillary and subcutaneous microvascular imaging is increased, the color tone of lesions is deeper, boundaries of the lesions and surrounding normal mucosa are clearer, blood vessel morphological changes and texture images can be observed clearly, and accordingly direct references can be provided for doctors to recognize the lesions, judge benign or malignant tumors and the like, diagnosis sensitivity can be improved, accuracy in lesion range judgment is achieved, and corresponding surgical operations can be guided.

The invention provides a special medical purpose formula food compound with a digestive tract immunoregulation function and a preparation method thereof, and belongs to the field of special food. Thespecial medical purpose formula food compound is prepared from L-glutamine, oligopeptide, protein peptide, probiotics and stachyose. The preparation method of the compound comprises the following steps of crushing, screening, premixing, blending, inert gas filling, sub-packaging and packaging. The compound and food or special food or a pharmaceutically acceptable carrier or accessory can be made into an oral preparation. The preparation can be powder or tablets or capsules or granules or oral liquid. The compound can be applied for preparing food or special food or medicines which have a protection effect on gastric mucosal lesions and can adjust intestinal flora.

The invention discloses a pharmaceutical composition for treating postpartum perineal mucosal lesions, so as to solve the problem of treatment of postpartum perineal mucosal lesions. The pharmaceutical composition is characterized by being prepared from the following crude drugs: bark of himalayan coralbean, smallflower bracketplant herb, bobbin, alpinia japonica, parasitic loranthus, radix ranunculi ternate, dark malt, burnt medicated leaven, Chinese ephedra root, spina gleditsiae, peach gum, and rhizome anemones altaicae. The clinical test shows that the pharmaceutical composition has the characteristics of good curative effect and high safety on treatment of the postpartum perineal mucosal lesions, and is worthy of clinical application and popularization.

The invention discloses a novel wound self-healing biological material, a preparation method and application thereof, and relates to the technical field of biological materials. The wound self-healing biological material comprises a solid component and a liquid component, wherein the solid component comprises a cationic water-soluble chitin derivative which is a chitin derivative soluble in purified water, and accounts for 0.1 to 100 weight percent of the total weight of solid component. The novel wound self-healing biological material has the advantages that the structure and performance of a molecular scaffold of the cationic water-soluble chitin derivative is close to those of skin and mucosal intercellular matrix mucopolysaccharide (such as hyaluronic acid), and is an excellent matrix material for the growth of skin and mucosal cells, and the self-healing of human skin and mucosal injury is promoted effectively by the antibiotic property of cationic macromolecules.

The invention discloses a preparation for protecting stomach, protecting liver and dissipating the effects of alcohol and application of the preparation. The preparation comprises the following components: a hericium erinaceus fruiting body extract, a hericium erinaceus mycelium extract, a coriolus versicolor fruiting body extract, pueraria lobata ultrafine powder, flos puerariae ultrafine powder, aloe gel powder and aloe whole-leaf powder, wherein the weight ratio of the hericium erinaceus fruiting body extract to the hericium erinaceus mycelium extract to the coriolus versicolor fruiting body extract to pueraria lobata ultrafine powder to flos puerariae ultrafine powder to aloe gel powder to aloe whole-leaf powder is (5-15):(6-10):(6-15):(25-40):(5-15):(2-12):(5-15). The preparation for protecting stomach, protecting liver and dissipating the effects of alcohol, provided by the invention, has an obvious inhibiting effect on the increasing of VLDL of model mice, can obviously relieve gastric mucosal lesion, can be used for daily health care of liver and stomach, and can be further used as health food before and after alcohol use.

The invention discloses application of acetic acid and a salt thereof. Acetic acid and the salt thereof can be applied to preparation of medicines for preventing or treating ethanol induced gastric mucosal lesion, and the salt is a pharmaceutically acceptable salt. Acetic acid can be used for activating the specific acceptor GPR43 of acetic acid and inhibiting inflammation reaction, and the signal path is the key of anti-inflammation and anti-oxidation of acetic acid. Acetic acid serving as a histone deacetylase inhibitor (HDACi) can be used for regulating gene expression, inhibiting inflammation reaction, and promoting expression of MUC5AC and IL-10 by GPR43 or by inhibiting HDAC so as to enhance mucosal defense and reduce inflammation and oxidative damage. Acetic acid can be used for reducing ethanol induced gastric mucosal lesion by resisting inflammation and oxidation and promoting expression of MUC5AC.

The invention relates to a kind of intestinal mucosa damage restoring agent as well as preparative method. It has solved many defects of traditional method such as no obvious therapeutic efficacy of digallic acid soybean protein to diarrhea caused by bacteria, fungus, virus, toxins and parasites, the increase of drug resistant strain and multidrug resistant strain, the increase of chemical resistance and drug tolerance of pathogenic bacteria. The product in the invention contains 15-100% (by weight) of digallic acid antimicrobial active protein. The preparing method of the invention: adopting digallic acid to load antimicrobial active protein. The total efficiency of the agent can reach 100%, the diarrhea symptoms of patients can be substantially released after 1 day of taken the medicine, after 2-3 days, the cure rate can reach 85% or more. The yield of the antimicrobial active protein in the invention is 80% or higher by weight.

The invention relates to a composition for treating a gastric ulcer combined gastrointestinal bleeding. The composition comprises the following active components in parts by weight: 8-25 parts of ginsenoside Re, 10-30 parts of ginsenoside Rg3 and 5-20 parts of ginsenoside Rh1. The composition has the effects of obviously improving the gastric mucosal lesion and gastric mucosal lesion, promoting the blood coagulation and stopping bleeding, and is capable of effectively treating and / or preventing gastrointestinal diseases of the gastric ulcer combined gastrointestinal bleeding and the like.

The invention provides an anti-alcohol drink used for protecting liver and gastric mucosa, and a preparation method of the drink. The method comprises the steps of mixing semen hoveniae, radix salviae miltiorrhizae, radix puerariae, radix codcnopsitis pilosulas, pericarpium citri reticulatae, fructus lycii, flos puerariae, fructus crataegi, radix glycyrrhizae and fructus ligustri lucidi according to a weight ratio, and decocting a mixture twice by using water with the weight 8 times that of the mixture; and combining filter liquors and performing reduced pressure concentration to prepare fluid extract. By building models of acute liver injury and gastric mucosal lesion of mice, tissue forms of the liver and the gastric mucosa are checked, and indexes such as ALT, AST, ALB and the like in serum are measured; an immunohistochemical method is used for detecting expression situations of MnSOD, BCL-2 and Caspase-3 of the liver; a fluorescent PCR method is used for detecting gene expression levels of Nrf2 and SOD of liver tissues; gastric mucosal lesion indexes, inhibition rates and content of endothelin-1 and the like of the gastric mucosa of each group of mice are measured; the protection effect of the drink on the liver and gastric mucosa of a mouse is comprehensively researched; and experimental data proves that the drink can improve oxidation resistance of the liver and inhibit liver cell apoptosis, and has the effect of protecting gastric mucosal lesion.

The present invention provides a composition for topical treatment of skin and mucosal membrane lesions comprising a synergistic combination of copper compound and hypericum perforatum extract.

The invention relates to the technical field of functional food processing, in particular to a hericium erinaceus tableting candy, and a preparation method and an application thereof. The invention provides the hericium erinaceus tableting candy which at least comprises the following ingredients in parts by weight: 40-60wt% of hericium erinaceus powder, 15-20wt% of lactose, 10-16wt% of isomaltooligosaccharide, 6-10wt% of maltodextrin, 4-8wt% of fructose and 0.5-1wt% of magnesium stearate. The hericium erinaceus does not contain any food prohibited auxiliary materials, and the tableting candy meets a food safety quality standard and has an active meaning in the application of preparing functional food and / or drugs capable of preventing and / or treating gastric mucosal lesion.

The invention provides a self-curing two-component ion and temperature double-sensitive digestive tract injured mucosa protective glue and a preparation method thereof. The self-curing two-component digestive tract injured mucosa protective glue comprises colloid liquid and fixing liquid. The colloid liquid comprises a temperature sensitive biological material, a gelation temperature regulator, abiological adhesive agent, an ion sensitive fixing agent and a dissolving liquid, and the fixing liquid is a water-soluble calcium solution, wherein the percentage ratio of the temperature sensitive biological material to the gelation temperature regulator to the biological adhesive to the ion sensitive fixing agent is (1-30):(0.5-5):(0.3-5):(0.2-1). The colloid liquid is in a liquid state at a temperature lower than the room temperature, and is sprayed on the mucosa of a digestive tract wound surface; then the fixing liquid is sprayed to avoid loss; and a colloid film is further formed at thebody temperature, so that the stimulation effect of intestinal tract digestive liquid on the digestive tract injured mucosa is avoided, and healing of the wound surface is promoted. Animal tests showthat the protective glue provided by the invention can obviously promote repair of the injured mucosa, and thus has healing promoting and protecting effects on the damage of mucosa of esophagi, stomachs and intestinal tracts.

Topical composition for the treatment of mucosal lesions It relates to a topical composition comprising specific amounts of: a) a hyaluronic acid or a pharmaceutically or veterinary acceptable salt thereof, b) one or more adhesive agents, and c) a non-absorbable antibiotic; to delivery devices comprising it; and to its uses in medicine, in particular, in the treatment and / or prevention of mucosal lesions; in the prevention of postpolypectomy syndrome; as adjuvant therapy to mechanical treatments in gastrointestinal perforations, and as sealant treatment in surgical anastomoses and leaks or fistulas in gastrointestinal tract.

The invention relates to microsphere capsules with an assistant protection function on gastric mucosal lesion. The microsphere capsules are prepared from, by weight, 20-40 parts of chitosan, 25-55 parts of pilose asiabell root extract, 20-50 parts of langehead atractylodes rhizome extract and 8-12 parts of radix notoginseng extract. The microsphere capsules with the assistant protection function on the gastric mucosal lesion have the advantages that the chitosan is taken as a carrier to be combined with the traditional Chinese medicines, and the chitosan and pilose asiabell root extract, langehead atractylodes rhizome extract and radix notoginseng extrac mutually cooperate for compatibility to achieve the effect of protecting the gastric mucosa; meanwhile, microspheres with the particle size about 10-150 micrometers are prepared by adopting an ultrasonic emulsion technology, absorption is good, and the bioavailability is high.