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63 results about "Kidney pelvis" patented technology

Urethelium carcinoma detection marker composition based on ONECUT2 and DMRTA2 gene methylation

The invention relates to the technical field of biomedical detection, in particular to a urinary tract epithelium cancer detection marker composition based on ONECUT2 and DMRTA2 gene methylation, which comprises a CpG island region of an ONECUT2 gene, a CpG island region of a DMRTA2 gene and a kit for detecting urinary tract epithelium cancer. The CpG island region of the ONECUT2 gene is located in chr18: 57441548-57441674, and the CpG island region of the ONECUT2 gene is located in The CpG island region of the DMRTA2 gene is located in chr1: 50418714-50418823, and the CpG island region of the DMRTA2 gene is located in chr1: The kit for detecting urothelial carcinoma comprises a first primer pair and a first probe which are used for specifically detecting the methylation state of the CpG island region of the ONECUT2 gene in the claim 1, and a second primer pair and a second probe which are used for specifically detecting the methylation state of the CpG island region of the DMRTA2 gene. The urinary tract epithelium cancer detection marker composition based on ONECUT2 and DMRTA2 gene methylation has high sensitivity and high specificity, the sensitivity and the specificity are both 90% or above, early-stage and low-grade urinary tract epithelium cancer can be effectively detected, comprehensive coverage is achieved, and the urinary tract epithelium cancer detection marker composition is not only suitable for bladder cancer, but also suitable for upper urinary tract epithelium cancer such as renal pelvis cancer and ureter cancer.
Owner:WUHAN AIMISEN LIFE TECH CO LTD

Ureteral stent external drainage device

The utility model belongs to the technical field of drainage devices, and discloses a ureteral stent external drainage device which comprises a hard silicone tube arranged outside a patient body, part of the hard silicone tube is located in the patient body, and the liquid inlet end of the hard silicone tube is fixedly connected with a soft silicone tube. The liquid inlet end of the soft silicone tube extends to a pelvis ureter connecting part of a patient to the interior of the ureter along a preset puncture path, a channel for conveying liquid along the preset path is formed between the soft silicone tube and the hard silicone tube, and the diameter of the channel is not smaller than that of the puncture needle; the hard silicone tube is provided with a fixing piece used for fixing the hard silicone tube, the fixing piece is located outside a patient body, after the hard silicone tube and the soft silicone tube are placed in the pelvic ureter in the patient body in an operation, the wound of the connecting portion of the pelvic ureter matched in the operation is supported through the soft tube, and effusion is guided to be discharged through the soft silicone tube and side holes in the soft silicone tube. The device can be placed in the body of a patient for a long time, and the replacement frequency is low.
Owner:TIANJIN CHILDRENS HOSPITAL

Ureter leading-in sheath with real-time pressure monitoring capability

The invention relates to the technical field of medical instruments, in particular to a ureter leading-in sheath with real-time pressure monitoring capability, which comprises a sheath tube and a sheath seat arranged at the near end of the sheath tube, the sheath seat is provided with a perfusion joint and a suction joint, and the sheath tube defines a channel for an instrument to pass through; the resistance detection piece is arranged on the sheath and is used for detecting the axial propelling resistance borne by the sheath tube when the sheath tube enters the human body cavity in real time and generating a resistance signal; the torque detection piece is arranged on the sheath and used for detecting the circumferential torque borne by the sheath tube when the sheath tube rotates in the human body cavity in real time and generating a torque signal; by arranging the detection system composed of the resistance detection piece, the torque detection piece and the pressure detection piece, objective operation guidance and over-limit early warning can be provided through real-time and quantitative force and pressure monitoring, and the risk of ureteral injury and renal pelvis high pressure related complications is greatly reduced.
Owner:AFFILIATED PEOPLES HOSPITAL OF NINGBO UNIV

Treatment of kidney disease using renal nerve denervation via the renal pelvis

In an illustrative embodiment, systems and methods for treating kidney disease in a human patient are disclosed. A method includes advancing a collapsible array of RF electrodes through a urinary tract of the patient in collapsed form and into a position in or near a renal pelvis. The effector is deployed to an expanded form to engage at least a portion of an interior wall of the renal pelvis. RF energy delivered through the array of electrodes target afferent nerves proximate the interior wall of the renal pelvis to inhibit or destroy their function. eGFR of the patient can be raised after treatment according to the method.
Owner:VERVE MEDICAL

Curved ureteral channel sheath

A ureteral channel sheath (UAS) is provided. The UAS includes an elastically deformable tube having a shape memory that includes an arcuate bend at a head end thereof that corresponds to an anatomical shape of a ureter inlet up to and through a junction into a renal cavity (renal pelvis), and an introduction funnel at a tail end of the tube. The UAS further comprises a corresponding dilator provided with a tubular body having a shape memory, the shape of which comprises an arcuate bend at the head end thereof, the arcuate bend substantially corresponding to the curved shape of the elastically deformable tube of the UAS.
Owner:帕韦尔维希涅夫斯基

A self-adapting high radial support ureteral stent

The application provides a ureteral stent with adaptive high radial support force, which comprises a ureteral segment, a renal pelvis end segment and a bladder end segment connected to two ends of the ureteral segment, and drainage holes are arranged on the side surfaces of the renal pelvis end segment and the bladder end segment; the renal pelvis end segment and the bladder end segment are curved segments, and the ureteral segment is a straight segment; the ureteral segment comprises an inner cladding layer, an intermediate adaptive support layer and an outer cladding layer, the inner cladding layer and the outer cladding layer are respectively arranged on the inner and outer sides of the intermediate adaptive support layer, the inner cladding layer is connected to the inner side of the renal pelvis end segment and the bladder end segment in a smooth transition mode, and the outer cladding layer is connected to the outer side of the renal pelvis end segment and the bladder end segment in a smooth transition mode; the intermediate adaptive support layer comprises a plurality of support members, and the plurality of support members are distributed along the axial direction and the circumferential direction of the ureteral segment.
Owner:INNOVEX MEDICAL CO LTD

Akimethod based on fusion of multi-modal image features

The application relates to the field of image analysis, in particular to an AKI diagnosis method fusing multi-modal image features, which obtains kidney area MRI and CT images, extracts kidney pelvis candidate response boundary change information, completes area alignment and multi-scale response fusion through path aggregation, priority judgment and directionality adjustment, outputs a diagnosis graph and combines abnormal expansion direction to optimize an image set. According to the application, a high-response pixel set of a kidney pelvis area in an MRI image is extracted, pixel density and edge gradient change trend are combined, boundary change feature groups are established, the spatial distribution characteristics of potential lesion areas in the image can be finely described, and the initial accuracy of lesion identification is enhanced. The connectivity stability and path consistency of a response block are taken as the measurement basis, a path sorting mechanism in path construction is introduced, and the structural integrity and boundary controllability are improved in the feature path screening stage.
Owner:SECOND MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL

An antibacterial-coated ureteral stent and implantation device thereof

The application relates to the technical field of antibacterial coating ureteral stents, and discloses an antibacterial coating ureteral stent, which comprises a telescopic liquid-permeating mechanism, and both ends of the telescopic liquid-permeating mechanism are provided with fixing mechanisms. The antibacterial coating ureteral stent and the implanting device thereof are provided with the telescopic liquid-permeating mechanism, the fixing mechanism, the guide wire mechanism and the pushing mechanism, can form elasticity through the vortex fixed end pipe and the spring permeation pipe during use, can self-adapt to the elastic telescoping of the ureter when the patient's body position changes or moves, and can form storage for the end part through the multilayer vortex structure of the vortex fixed end pipe, so that rigid contact of the top end with the renal pelvis and the bladder wall is avoided, and the comfort of the patient is improved.
Owner:THE THIRD MEDICAL CENT OF THE CHINESE PEOPLES LIBERATION ARMY GENERAL HOSPITAL

Children urinary system image and pathological image reconstruction and analysis system based on multi-modal data

The invention discloses a children urinary system image and pathological image reconstruction and analysis system based on multi-modal data, which belongs to the technical field of image processing and comprises a multi-modal data input module, a key area positioning module, a dynamic selective preprocessing unit and a reconstruction analysis module. The multi-modal data input module is used for receiving multi-modal data of a child urinary system and performing format standardization; the key area positioning module is used for positioning a key area and a non-key area of the urinary system of the child. According to the method, only high-compression-ratio storage, simplified denoising and other low-intensity processing are executed on a non-key area, and the calculation steps and carrying cost of redundant data are greatly reduced; the key areas such as the pelvis and the ureter opening are preprocessed according to the characteristics of the key areas, and it is ensured that diagnosis core information is not lost. According to the processing mode, the rigid contradiction that the full-amount processing efficiency is low and the full-amount simplification feature is damaged is solved, and the accurate balance between the efficiency and the integrity is realized.
Owner:昆明市儿童医院(云南省儿童医院)

Ureter guide sheath capable of reducing internal pressure of renal pelvis and bladder pressure

The utility model belongs to the field of ureter guiding sheaths, particularly relates to a ureter guiding sheath capable of reducing internal pressure of a renal pelvis and pressure of a bladder, and aims to solve the problems that when an existing guiding sheath injects water into a kidney during an operation, the pressure of the kidney is too large, water flows back into blood, infection risk is increased, and the operation time is prolonged. Liquid in the bladder is gradually increased, bladder pressure is increased, the bladder is overfilled, and the bladder function is damaged. According to the scheme, the catheter comprises a guide sheath tube, a bendable catheter is arranged at the front end of the guide sheath tube, a plurality of evenly-distributed second holes are formed in the outer portion, away from the bendable catheter, of the guide sheath tube, and a plurality of evenly-distributed first holes are formed in the outer portion of the front end of the bendable catheter and the outer portion of the front end of the guide sheath tube. Through the arrangement of the first hole and the second hole, liquid in the kidney and the bladder can be further drained out of the body through the liquid passing ability of the measuring holes, the pressure in the kidney and the pressure of the bladder are effectively relieved, and it is ensured that drainage is more sufficient and effective.
Owner:核工业四一六医院

Disposable bladder renal pelvis ureter flexible mirror system with intelligent temperature and pressure control function

PendingCN122123632ASurgeryEndoscopesFlexible ureteroscopyKidney pelvis
This invention relates to the field of ureteroscopic surgery technology, providing a disposable flexible cystoscopic, pyelonephric, and ureteroscopic system with intelligent temperature and pressure control functions. The system includes a disposable flexible endoscope body and an intelligent temperature and pressure control unit. The disposable flexible endoscope body includes a mid-section flexible insertion tube, a distal sensing lens tip, and a proximal operating handle. The distal sensing lens tip integrates an in-situ temperature and pressure measurement sensor, a miniature imaging module, an illumination fiber optic bundle, an instrument operating channel outlet, an irrigation channel outlet, and a suction channel outlet. Precise real-time monitoring is achieved through the in-situ temperature and pressure sensor at the tip, combined with dual-channel closed-loop control, keeping renal pelvic pressure fluctuations and temperature errors within a safe range, thus reducing the risk of infection and thermal damage at the source. The integrated structure eliminates the need for a pressure measuring sheath, resulting in less trauma and lower cost. Furthermore, the fully automated control significantly shortens the learning curve, greatly improving safety and practicality.
Owner:ZHEJIANG MINGKE MEDICAL OPTICAL TECH CO LTD

Head-end-bendable ureter leading-in sheath with fixed balloon device

The utility model relates to the technical field of ureter leading-in sheaths, solves the technical problem that a leading-in sheath cannot be limited in a urethra, and particularly relates to a ureter leading-in sheath with a bendable head end and a fixed balloon device, which comprises a protective tube serving as a supporting foundation, the inner side of the protection tube is provided with a limiting and steering assembly used for limiting and steering the guide-in sheath, the limiting and steering assembly is provided with a calculus discharging assembly used for discharging calculus broken stone, the limiting and steering assembly comprises a guide-out tube arranged on the inner side of the protection tube, and one end of the guide-out tube is connected with a limiting bag. Due to the arrangement of the limiting steering assembly, after the guiding-in sheath is inserted into the pelvis, the balloon is limited in the bladder by injecting water into the limiting bag, the stability of the guiding-in sheath in the urethra can be improved, and the fixing sheath can effectively reduce the pressure of the pelvis and reduce the risk of infection.
Owner:ANHUI LAIKANG MEDICAL EQUIP CO LTD

Product and method for detecting urothelial carcinoma based on DNA methylation

The invention provides a product and a method for detecting urinary tract epithelial carcinoma based on DNA methylation, and belongs to the technical field of urinary tract epithelial carcinoma detection, the product comprises reagents for detecting methylation of the following DNA regions: a PENK gene CpG island region Chr8: 56446618-56446724, a TMEM106A gene CpG island region Chr17: 43211685-43211847, and an OTX1 gene CpG island region Chr2: 63056808-63056956. Through joint detection of the target gene areas, accurate prediction of urothelial carcinoma is realized, and the kit has comprehensive coverage (bladder cancer, pelvis cancer and ureteral cancer) and detection advantages of early and low-grade cancers, can be used for early screening, postoperative recurrence monitoring, prognosis evaluation and other stages, and has a wide application prospect in the fields of early screening, postoperative recurrence monitoring, prognosis evaluation and the like. The positive significance is realized on the whole disease course management of the urothelial carcinoma.
Owner:WUHAN AIMISEN LIFE TECH CO LTD

Renal scoring method and device for kidney tumor

PendingCN120977550AImage enhancementImage analysisNatural coordinate systemKidney pelvis
The invention discloses a Renal scoring method and device for kidney tumors, and belongs to the field of medical image processing. The method comprises the steps that segmentation data are acquired, and the segmentation data comprise data of kidneys, tumors and blood vessels; anatomical analysis is carried out based on the segmentation data, the kidney principal axis, the renal pelvis position and the ureter are determined, and a natural coordinate system of the kidney is established; calculating the maximum diameter of the tumor based on the tumor voxel, and determining an R score according to the maximum diameter of the tumor; constructing a kidney convex hull based on the kidney parenchyma coordinates, and determining an E score based on the proportion of tumor voxels inside and outside the kidney convex hull; taking the ureter as a set system, determining the minimum distance from the tumor voxel to the set system, and determining an N score according to the minimum distance; constructing a natural interface based on the pelvis position, and determining an A score based on the natural interface; detecting polar lines based on the renal door depression, and determining an L score according to the polar lines. The method provided by the invention eliminates the subjective judgment difference of the scorer.
Owner:SHANDONG UNIV QILU HOSPITAL +1

Artificial neural network–based method for evaluating renal tumor and device for evaluating renal tumor using same

The present invention provides a renal tumor evaluation method and an evaluation device and system using same. The method, which is implemented by a processor, comprises the steps of: receiving a medical image including a kidney and a renal tumor; generating three-dimensional image data from the medical image; segmenting, in the received three-dimensional image data, regions corresponding to the tumor, the renal parenchyma, the renal pelvis, and the renal hilum by using a prediction model trained to segment the regions of the tumor, the renal parenchyma, the renal pelvis, and the renal hilum using three-dimensional image data as input; determining, on the basis of the segmented regions, a first boundary surface between the tumor and the renal parenchyma or a second boundary surface between the tumor and the renal hilum; determining a first distance between the first boundary surface and the renal hilum or a second distance between the second boundary surface and the renal hilum; and performing renal tumor evaluation on the basis of the first distance or the second distance.
Owner:IND ACADEMIC COOP FOUND YONSEI UNIV

Auxiliary supporting guide wire for torsion of ureter

PendingCN122075894AAvoid "stick-slip" damageAvoid the risk of pressure surgesGuide wiresSurgeryKidney pelvisUretero-ureteral
The invention relates to the technical field of medical auxiliary instruments, in particular to a ureter distortion auxiliary supporting guide wire which comprises an extension guide wire, a position guide wire, a guide wire head and a connecting sleeve seat. The position guide wire is provided with an expansion base ring and at least three sets of plate type expansion assemblies driven by a pneumatic mechanism I. The plate type expansion assemblies drive arc-shaped expansion plates to swing through tooth bars, point type and controllable expansion of the narrow portion of the ureter is achieved, and the problems of mucous membrane damage and complete lumen blockage caused by large-area contact of a traditional air bag are solved. And meanwhile, an air cavity and at least three groups of radial movement positioning assemblies driven by a pneumatic mechanism II are arranged in the guide wire head, and an arc-shaped positioning plate is pushed by a multi-stage telescopic cylinder to extend out in the radial direction to form multi-point contact with the inner wall of the renal pelvis, so that stable anchoring of the guide wire head is realized. The operation injury risk can be effectively reduced, smooth perfusion is guaranteed, and the positioning stability of the guide wire in the renal pelvis is improved.
Owner:JIANGSU CHANGSHOU STICK TECH CO LTD

Anti-reflux ureteral stent

ActiveCN224235896UStentsWound drainsKidney pelvisUrine reflux
The utility model discloses an anti-reflux ureteral stent, which belongs to the technical field of ureteral stents and comprises a stent pelvis section, a stent ureteral section and a stent bladder section. At least one hollow expansion part is arranged on the tube wall of the bladder section of the stent, and an integrated anti-reflux valve is arranged in a tube cavity of the expansion part. The valve is composed of a plurality of valve-shaped structures, the free ends of the valve-shaped structures can be close to each other to seal a lumen when subjected to retrograde liquid pressure from the bladder to the kidney, the free ends of the valve-shaped structures are separated from each other to open the lumen when subjected to forward liquid pressure from the kidney to the bladder, and therefore one-way drainage of urine is achieved. The anti-backflow urine bag is simple in structure and capable of effectively preventing backflow of urine and complications such as lumbago and hydronephrosis caused by backflow of urine. Meanwhile, due to the structure of the expansion part, the valve can be completely attached to the wall when opened, and operation smoothness and safety are guaranteed when a guide wire is placed in.
Owner:SOUTHEAST UNIV

Multifunctional spherical bladder section ureter stent tube

PendingCN121729257ACatheterUreter stentKidney pelvis
The invention relates to medical equipment, in particular to a ureteral stent tube with a spherical bladder section (3). The technical problems that a traditional double-pigtail ureter support pipe needs to be placed under direct vision, bladder stimulation is obvious, and no anti-reflux structure exists are solved. The bladder section (3) of the ureteral stent tube is designed to be in a sphere-like shape, the function of a limiting head can be achieved, the ureteral stent tube can be placed in place without endoscope monitoring, stimulation of a thin tubular structure to the bladder can be avoided, and meanwhile the interior of the sphere-like structure can provide enough space for containing an anti-reflux one-way valve (6). Comprising a renal pelvis section (1), a ureter section (2) and a bladder section (3), the renal pelvis section (1) is in a bent tube shape, the ureter section (2) is in a straight tube shape, the bladder section (3) is of a sphere-like structure, the sphere-like structure of the bladder section (3) comprises a round ball, a flat ball, a hemisphere, a heart shape, a concave core ball and the like, the ureter section (2) is directly connected with the bladder section (3), and drainage holes can be formed in the wall of the sphere-like structure of the bladder section (3). And structures such as an anti-reflux one-way valve (6) can be arranged inside.
Owner:钱庆鹏

Home body position calculus removal guiding device

The utility model belongs to the technical field of medical equipment, and provides a home body position calculus removal guiding device which comprises a fixed base, a movable base and a guide rod. The kidney model is arranged on the fixed base, a ureter is arranged on the kidney model, and the kidney model is a transparent material model; a renal pelvis cavity, a kidney large calyx cavity and a kidney small calyx cavity are formed in the kidney model, and the ureter, the renal pelvis cavity, the kidney large calyx cavity and the kidney small calyx cavity are used for simulating the ureter, the renal pelvis, the kidney large calyx and the kidney small calyx of the human kidney respectively. The transparent kidney model is convenient for the patient to intuitively observe the movement track of the stone-like member in the kidney model under different body positions. When the kidney model is used, a patient can wear the kidney model at the preset position of the waist, and the body position is changed according to the dynamic condition of the stone-like piece in the kidney model until the stone-like piece is discharged out of the pelvis. Therefore, the cost of the body position drainage bed for the patient is reduced, the hospital return frequency of the patient is reduced, and the body position calculus removing efficiency of the patient is improved.
Owner:THE UNIVERSITY OF HONG KONG SHENZHEN HOSPITAL

Methods and systems for identifying different types of cancer cells in a patient with renal pelvis cancer based on urine

ActiveCN115232875BKidney pelvisCancer cell
The present application relates to the field of cancer cell identification, and particularly relates to a method and system for identifying different types of cancer cells of a renal pelvis cancer patient based on urine, the method comprising: collecting a urine sample, obtaining a detection sample by using the urine sample; sequencing the detection sample to obtain a cell expression profile of the detection sample; obtaining cell expression profile data of a mixed urothelial cell subpopulation by using the cell expression profile, the mixed urothelial cell subpopulation comprising normal urothelial cells and cancerous urothelial cells; extracting different proto-oncogene expression data from the cell expression profile data of the mixed urothelial cell subpopulation; analyzing the different proto-oncogene expression data to obtain a cancer cell ratio and identify different types of cancer cells. The present method quickly and accurately obtains different types of cancerous urothelial cells through non-invasive examination and proto-oncogene expression profile data, and provides a reference and basis for preoperative neoadjuvant therapy of renal pelvis cancer.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

Use of electricity to enhance the delivery of pharmaceutical agents and other substances into the surface mucosa and wall of the ureter and renal pelvis, and into the renal parenchyma

A medical urology device for drug delivery to the lining and deeper tissues of the ureter and kidney. The present invention features an electromotive drug administration (EMDA) catheter device for deploying a fluid to deep tissues of a patient. The device includes a catheter body with fenestrations along its distal length. The device may further comprise a multiport component for allowing access to the catheter body. The device may further comprise a conductive wire removably disposed through the multiport component within the catheter body. Fluid may be directed through the multiport component and the plurality of fenestrations to the body structure of the patient. Electrical stimulation directed through the conductive wire enhances the penetration of medications with the same polarity to electrical stimulation into a body structure of the patient to allow the fluid to penetrate deep tissues.
Owner:RGT UNIV OF CALIFORNIA

Multi-cavity ureter sheathing canal system integrating flushing and pressure monitoring functions

InactiveCN121490231ASuture equipmentsInternal osteosythesisFlexible ureteroscopyKidney pelvis
The invention discloses a multi-cavity ureter sheathing canal system integrating flushing and pressure monitoring functions, and relates to the technical field of medical instruments, the multi-cavity ureter sheathing canal system is characterized by comprising a sheathing canal main body and a micro-catheter channel, the micro-catheter channel is integrated in the wall of the sheathing canal main body, and the micro-catheter channel is communicated with the sheathing canal main body. The sheathing canal main body is provided with a main working channel penetrating through the sheathing canal main body, and the micro-catheter channel and the main working channel extend in parallel; a flexible ureteroscope is arranged in the main working channel in a penetrating mode, and a lateral suction connector is arranged at the near end of the main working channel and used for being connected with a negative pressure suction device. The near end of the sheath tube body is connected with a ureter sheath base, and a water sealing cap is connected to an opening in the near end of the ureter sheath base. The system can continuously supplement perfusate to the pelvis during negative pressure suction, maintain the shape of the pelvis, avoid mucosal injury and realize real-time and accurate pressure monitoring in an operation, so that the broken stone removal efficiency and the operation safety are remarkably improved.
Owner:李羿贤

Water-lubricity composite balloon ureteral dilator

The utility model discloses a water lubricity composite balloon ureteral dilator, and relates to the technical field of ureteral dilators, the ureteral dilator comprises a dilator, the top of the dilator is provided with a flaring, the outer part of the dilator is provided with a dilation mechanism, and the lower end of the dilator is fixedly provided with a guide tube. Under the cooperation of the upper connecting pipe, the first dilatation balloon, the lower connecting pipe, the second dilatation balloon, the catheter, the connector and the hydrophilic adhesive film, dilatation of a narrow part can be achieved, meanwhile, the semi-ellipsoid-shaped dilatation balloon can reduce the occupied space in a cavity, meanwhile, the whole operation process is simple and convenient, and the working efficiency is improved. And through the guide wire channel and the formed containing cavity, the ureteral dilator can be safely and smoothly placed into a ureteral cavity under the guidance of the guide wire, a ureteral submucous false channel and a ureteral perforation are prevented from being formed, and after the guide wire is withdrawn, the effect of temporarily draining urine in the pelvis can be achieved.
Owner:SHENZHEN TAIRUISHI MEDICAL TECH CO LTD

Construction method of BBN-induced mouse upper urinary tract and urinary tract epithelium cancer in-situ tumorigenesis model

ActiveCN121464982AAnimal husbandryURINARY BLADDER CARCINOMAKidney pelvis
The invention relates to the technical field of animal model construction methods, in particular to a construction method of a BBN (N-butyl-N-(4-hydroxybutyl) nitrosamine) induced upper urinary tract urothelial carcinoma animal model, according to the method, BBN (N-butyl-N-(4-hydroxybutyl) nitrosamine is used for conducting drinking water administration treatment at different stages and with different concentrations on a mouse, and the in-situ tumorigenesis upper urinary tract urothelial carcinoma animal model is formed through induction. According to the technical scheme, the problem that in the prior art, BBN can only induce urothelium carcinoma mainly including bladder cancer can be solved, the whole development stage of animal pelvis cancer and ureteral cancer from early abnormality to advanced cancerization can be observed through the upper urothelium carcinoma animal model constructed through the technical scheme, and the mechanism of different disease courses can be researched conveniently. The animal model is expected to further explain the occurrence and development mechanism of the upper urinary tract epithelial cancer and screen new therapeutic drugs, and has ideal application prospects.
Owner:PEKING UNIVERSITY FIRST HOSPITAL (PEKING UNIVERSITY FIRST CLINICAL MEDICAL COLLEGE)

A gender-neutral urine-based mirna test for detecting urological cancers

PCT designated stageWO2026050611A1Microbiological testing/measurementDisease diagnosisEarly Cancer DetectionKidney pelvis
The present invention provides a gender-neutral, non-invasive diagnostic method for detecting urological cancers, including prostate, bladder, kidney, renal pelvis, and testis cancers, using urine-based microRNA (miRNA) biomarkers. The method comprises obtaining a self-collected urine sample, extracting miRNA, and quantifying biomarker expression levels using, e.g., reverse transcription quantitative PCR (RT-qPCR), next-generation sequencing (NGS), or microarray analysis. A panel of miRNAs, e.g., hsa-let-7b-5p, hsa-miR-26b-5p, hsa-miR-145-5p, hsa-miR-4253p, hsa-miR-195-5p, hsa-miR-203a-3p, hsa-miR-30c-5p, and hsa-miR-30a-3p, enables sensitive and specific discrimination between cancer and non-cancer patients. The invention is capable of high diagnostic performance and accuracy. The assay may be highly reproducible. This present invention provides a cost-effective, non-invasive, inclusive platform applicable across cisgender, transgender, and non-binary populations, facilitating early cancer detection and improved healthcare accessibility.
Owner:NOTHING CREATIVE LLC

Ureteral catheter capable of dynamically monitoring pressure

The invention relates to the field of ureters, and discloses a ureteral catheter capable of dynamically monitoring pressure, comprising: a flexible pigtail tube for supporting the whole device, the flexible pigtail tube is a hollow tube, the flexible pigtail tube is provided with a plurality of groups of catheterization holes, and the inner wall of the flexible pigtail tube is provided with a renal pelvis pressure sensor; the bladder end bent tube is used for extending into the bladder of the patient and connected with one end, far away from the pelvis pressure sensor, of the bendable pigtail tube, a tail tube hanging ring is arranged at the other end of the bendable pigtail tube, and a bladder pressure sensor is mounted on the inner wall of the bladder end bent tube; and the inner walls of the bladder end bent tube and the bendable pigtail tube are jointly provided with two groups of channels. By means of the bladder pressure sensor arranged in the bladder end bent pipe, bladder pressure can be monitored in real time and transmitted to terminal equipment such as a display screen through Bluetooth, and by monitoring the bladder pressure, a patient can be guided to judge whether urinary catheterization is needed to reduce the bladder pressure or not, and urine backflow to the pelvis is reduced.
Owner:THE SECOND HOSPITAL OF DALIAN MEDICAL UNIV

Gender-neutral urine-based mirna test for detecting urological cancers

PendingUS20260062758A1Microbiological testing/measurementDisease diagnosisEarly Cancer DetectionKidney pelvis
The present invention provides a gender-neutral, non-invasive diagnostic method for detecting urological cancers, including prostate, bladder, kidney, renal pelvis, and testis cancers, using urine-based microRNA (miRNA) biomarkers. The method comprises obtaining a self-collected urine sample, extracting miRNA, and quantifying biomarker expression levels using, e.g., reverse transcription quantitative PCR (RT-qPCR), next-generation sequencing (NGS), or microarray analysis. A panel of miRNAs, e.g., hsa-let-7b-5p, hsa-miR-26b-5p, hsa-miR-145-5p, hsa-miR-4253p, hsa-miR-195-5p, hsa-miR-203a-3p, hsa-miR-30c-5p, and hsa-miR-30a-3p, enables sensitive and specific discrimination between cancer and non-cancer patients. The invention is capable of high diagnostic performance and accuracy. The assay may be highly reproducible. This present invention provides a cost-effective, non-invasive, inclusive platform applicable across cisgender, transgender, and non-binary populations, facilitating early cancer detection and improved healthcare accessibility.
Owner:NOTHING CREATIVE LLC

Ureteral stent capable of being flexibly positioned in real time

The invention relates to the technical field of medical supplies. A flexible real-time positioning ureteral stent comprises a ureteral stent body, an optical fiber real-time positioning module is arranged at the pelvis end of the ureteral stent body, and an umbrella-shaped floating stent body is arranged at the bladder end of the ureteral stent body; the umbrella-shaped floating support comprises a thermal response support, a hidden groove is formed in the position, corresponding to the thermal response support, of the outer wall of the ureter support, and the thermal response support can be contained in the hidden groove in the initial state. According to the ureteral stent capable of being flexibly positioned in real time, friction to the triangular area of the bladder can be effectively avoided, the safety of a patient is guaranteed, whether the pelvis end stent is in place or not can be judged in real time in an operation, and calculi can be early warned; the technical problems that in the prior art, an existing traditional ureter support is single in structure, the bladder end rubs a triangular area for a long time, other diseases are likely to be caused, whether the pelvis end is in place or not is inconvenient to confirm, and higher practical requirements cannot be met are solved.
Owner:CHANGSHU HOSPITAL OF TRADITIONAL CHINESE MEDICINE (CHANGSHU NEW DISTRICT HOSPITAL)

Flexible ureteroscope sheath system

The flexible ureteroscope sheath system comprises an outer sheath tube, an intelligent control host and a negative pressure drainage pipeline. A groove is formed in the inner wall of the far end of the outer sheath tube, a pressure detection unit is embedded in the groove, the surface of the pressure detection unit is covered with a pressure-permeable protective film, and the signal line is connected with the intelligent control host through a signal transmission channel in the wall of the outer sheath tube. And the negative pressure drainage pipeline is communicated with the negative pressure interface at the near end of the outer sheath tube. And the intelligent control host receives the real-time pressure value, compares the real-time pressure value with a preset upper limit threshold value and a preset lower limit threshold value, controls the output of the adjustable negative pressure source or controls the pressure relief unit to act, and outputs an alarm signal in a continuous abnormal state. The intraoperative pelvis pressure monitoring system can realize real-time monitoring and dynamic adjustment of intraoperative pelvis pressure, and also considers drainage, pressure management and abnormity prompt.
Owner:THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL

Pelvis internal pressure and excessive expansion monitoring system based on patch type multi-probe ultrasound

The invention discloses a pelvis internal pressure and excessive expansion monitoring system based on patch type multi-probe ultrasound, and relates to the technical field of ultrasonic diagnosis and monitoring. According to the invention, a patch type multi-probe ultrasonic transducer is used as a hardware basis, high-quality original ultrasonic signals are provided, processed accurate pelvis form data and strain distribution data are combined as supports, multi-data fusion with individual characteristics of a patient is carried out, and a multi-module deep collaborative monitoring system is constructed. Reliable internal pressure estimation values and volume data are input into an early warning module for dynamic threshold adjustment, graded early warning response and data tracing management, the accurate and personalized dynamic monitoring function of renal pelvis internal pressure and excessive expansion in a non-invasive state is achieved, dynamic monitoring and risk early warning of kidney function related indexes can be completed in a non-invasive mode in the whole process, and the reliability of renal pelvis internal pressure and excessive expansion is improved. Complete data support is provided for clinically formulating individualized diagnosis and treatment schemes and early intervention of kidney injury, and diversified clinical requirements of long-term monitoring and emergency response are met.
Owner:THE THIRD MEDICAL CENT OF THE CHINESE PEOPLES LIBERATION ARMY GENERAL HOSPITAL