385results about How to "Non-traumatic" patented technology

The invention relates to an active controllable type capsule endoscope robot system comprising a capsule endoscope robot, a receiving memory, a motion control box and an image display system. A driving mechanism of the capsule endoscope robot generates the radial expansion and contraction of an oil bag and the extension and contraction of a capsule by a direct-current motor, a double-shaft multiplexing speed reducer and a geometer motion distribution mechanism and realizes progression and retrogression by matching according to a certain time sequence; after the capsule endoscope robot enters the gastrointestinal tract of a human body by oral administration, the capsule endoscope robot shoots the image information of each position of the gastrointestinal tract at real time by the self geometer creeping and transmits the image information outside the body in a wireless mode. In a part outside the body, the receiving memory is used for receiving and storing image data transmitted by the capsule endoscope robot in a wireless way; the motion control box controls the progression, the retrogression or the stop of the capsule endoscope robot in a wireless transmission mode so as to repeatedly observe a questionable position in the gastrointestinal tract; and the image display system reads and processes the image data recorded in the receiving memory at real time by a computer so as tobe observed and diagnosed by a doctor.

The invention relates to a watch-type non-trauma optical acoustic blood sugar monitor. A display screen, a control button, a controller, a cell and a measurement box are arranged in watch-type casing, an acoustic insulating layer, a sound absorption pad, a semiconductor laser tube, a Fourier lens, a light-transparent protection film and a hollow multi-ring array sensor are packaged in the measurement box to form a integrated coaxial confocal structure. The watch-type casing is equipped with a watchband to be wore on wrist of detector, an optical acoustic excitation source and an optical path lens system generate focused laser beam which passes through the hollow multi-ring array sensor and radiates to blood vessel of wrist to realize optical acoustic blood sugar detection of continuous A-type dynamic focusing scan and provide optical acoustic blood sugar results of multiple sites along wrist depth direction. The monitor has advantages of having small structure and simple operation, realizing real-time monitoring of optical acoustic blood sugar, having no trauma when detecting, having no need of blood supply and test paper, and avoiding cross infection and environmental influence.

A personalized stereo health index measuring method and device features that the variation of multiple physiologic data in different psychological and spirits states of a person is monitored to indicate its health state and health potential.

The invention provides a traditional Chinese medicine gastrointestinal auxiliary for type-B ultrasonic and a preparation method thereof, and the traditional Chinese medicine comprises the following raw medicinal materials: cumin, galangal, rhizome cyperi, three-nerved spicebush roots, cuttlebone, green tangerine peels, medicated leaven, malts, immature bitter orange, rheum officinale, mirabilite, cortex magnoliae officinalis, radix aucklandiae, amomum, agastache rugosa, finger citron, hawthorns, radish seeds, calcined concha arcae, evodia, pinellia ternate, semen arecae, atractylodes macrocephala koidz, rhizoma nardostachyos and fritillary bulb. The traditional Chinese medicine gastrointestinal auxiliary for type-B ultrasonic has the beneficial effects of being safe to use, painless, noninvasive, non-toxic, free from anaphylactic reaction, short in examination time, high in development rate, convenient to use and low in cost, providing a new technology and a new method for corrective early-stage diagnosis of diseases, and powerful basis for clinical diagnosis, and being a desirable novel auxiliary. Furthermore, the preparation process is simple and practical.

The invention discloses a blood flowing detection device and method. The detection device comprises an inflation pressure binding belt, a detection host, as well as a temperature sensor and a humidity sensor which are connected with the detection host; and the detection host comprises a control button, a switching voltage-stabilized power supply circuit, a singlechip microcomputer central control-processing unit, a preamplifier, an A / D (analog-to-digital) conversion circuit, a display and a buzzer. The detection method comprises the following steps: releasing restriction after a blood flow atthe proximal end of a heart is restrained for a certain period of time; measuring changes of skin temperature and humidity on a position at a distal end of the heart, and comparing the changes with the standard parameters of people with a normal blood flowing condition; determining whether a testee has vascular endothelial dysfunction or not; and evaluating the severity of early symptoms of cardiovascular sclerosis and hemodynamics of the testee. The detection device has the advantages of simple structure, low cost and convenience for operation, causes no trauma or pain, and can be used for routine physical examination and community general examination.

The invention provides a traditional Chinese medicine contrast medium adjuvant used for B ultrasonic, which comprises the following materials in part by weight: 10-20 parts of bighead atractylodes rhizome, 10-20 parts of poria cocos, 10-20 parts of turmeric, 10-20 parts of tangerine peel, 10-20 parts of cortex magnoliae officinalis, 10-20 parts of radix aucklandiae, 10-20 parts of Rhizoma atractylodis, 10-20 parts of cuttlebone, 10-20 parts of calcined oyster shell, 10-20 parts of Chinese yam, 10-20 parts of charred triplet, 10-20 parts of myristica fragrans, 10-20 parts of gizzard pepsin, 10-20 parts of rhizome cyperi, 10-20 parts of codonopsis pilosula, 10-20 parts of combined spicebush root, 10-20 parts of eclipta, 10-20 parts of jasmine, 10-20 parts of baical skullcap root and 10-20 parts of field pennycress. The traditional Chinese medicine contrast medium adjuvant used for B ultrasonic provided by the invention not only can adapt to stomach hyperfunction type, but also can adapt to decreased stomach function type, and also can be applied to the mixed type of various flatulence and mucinosis, check time is short, imaging rate is high, and preparation process is simple and practical. The contrast medium adjuvant has no obvious toxic side effect and has prospect on further development research.

The invention discloses oral cavity comprehensive detecting method and apparatus based on a flexible phase controlled ultrasonic array. The apparatus comprises a display module, a phase controlled ultrasonic transmitting module and a phase controlled ultrasonic receiving module connected with a control module, respectively. The phase controlled ultrasonic transmitting module and the receiving module are further connected with a flexible phased array ultrasonic transducer array. The method comprises the following steps of: performing ultrasonic scanning to detect teeth facing outwards skin in periphery of the oral cavity on the face or in all directions of other soft tissues of the oral cavity through the flexible phased array ultrasonic transducer array; transmitting ultrasonic waves with set frequency to detection points through the phased array focused ultrasound when detecting the teeth so as to detect the amplitude of the reflected wave and detect whether defect waves exist in the reflected wave; and transmitting ultrasounds with different frequencies to the detection points through the phased array focused ultrasound and detecting the attenuation of the transmitted wave with different frequencies at the other end when detecting the soft tissues of the oral cavity so as to obtain broadband ultrasonic attenuation parameters. Therefore, health states of the soft tissues of oral cavity can be obtained rapidly.

The invention provides a human DNRG4 / TFPI2 gene methylation detection marker and a reagent kit. The human DNRG4 / TFPI2 gene methylation detection marker comprises capture primers, methylation primers and probes of three genes of ACTB, NDRG4 and TFPI2. The marker can be used for performing detection and auxiliary diagnosis on colorectal cancer and prediction and treatment effect evaluation on relapse and has the advantages of being high sensitivity and specificity and low in detection cost, materials are easy to get, and samples are easy to store.

The present invention discloses a noninvasive blood glucose detection instrument basing on the energy conservation principle, which includes a blood glucose detection sensor, a signal processing circuit, a simulation filter circuit, an amplifying circuit, an A / D converter, a communication circuit, a display, a single chip microcomputer, a personal computer and a blood oxygen detection module. The blood glucose detection sensor, the signal processing circuit, the simulation filter circuit, the amplifying circuit and the A / D converter are connected successively in series. The blood glucose detection instrument detects physiological quantity signals of a human body. The signals are pretreated by the signal processing circuit, the simulation filter circuit and the amplifying circuit and are converted into digital signals by the A / D converter to be transmitted to the single chip microcomputer. Then, the digital signals are transmitted to the personal computer through a communication circuit. The personal computer processes the detected data, finishes the calculation of the blood glucose concentration and displays the calculation results. Through the parameters of the detections of the convection, the radiation and the heat evaporation dissipating capacity of finger surfaces, the blood flow and the blood oxygen saturation of local tissues, etc., the present invention realizes the blood glucose fast detection, which has the advantages of painless performance, disinfection and simple and rapid performances.

The invention discloses a traditional Chinese medicine shadow assisting agent used in B-ultrasound and a preparation method thereof, and the shadow assisting agent comprises various materials with the following weight proportions: 10 to 20 portions of abalone shell, 10 to 20 portions of concha mauritiae, 10 to 20 portions of medicated leaven, 10 to 20 portions of radix codonopsitis, 10 to 20 portions of atractylodes, 10 to 20 portions of tuckahoe, 10 to 20 portions of bletilla striata, 10 to 20 portions of field pennycress, 10 to 20 portions of radix linderae and 10 to 20 portions of radix aucklandiae. The traditional Chinese medicine shadow assisting agent used in B-ultrasound has safe usage, no pain, no wound, no toxicity, no allergy reaction, short checking time, high imaging rate, convenient i usage, easy application and low cost, and provides a new technology and new method for the accurate diagnosis of diseases at early stage, and provides a powerful foundation for the clinical diagnosis, and the traditional Chinese medicine shadow assisting agent is a comparatively ideal novel shadow assisting agent.

The invention relates to a non-contact type magnetic induction imaging system and an imaging method thereof. The imaging system comprises a signal generating module, a signal transmitting module, a control module, a signal receiving module, a signal processing module and an image display module. The control module controls the signal generating module to generate a single-frequency radio frequency signal, the radio frequency signal is applied into the signal transmitting module in an alternating current mode, an alternating magnetic field is generated through the alternating current, the signal receiving module receives the alternating magnetic field and transmits the received signal to the signal processing module through the control module, the signal processing module reconstructs the received signal to obtain a two-dimensional restructured image of a target living body, and the two-dimensional restructured image is transmitted to the image display module to be displayed. The imaging method comprises the steps of electromagnetic wave stimulation, echo signal measuring, target living body two-dimensional imaging processing and two-dimensional restructured image display.

The invention discloses an antibacterial medical suture and a production method thereof. A titanium-nickel memory alloy thread is adopted as a base material of the antibacterial medical suture. A silver-ion cladding layer with thickness of 0.1-1 micrometer is deposited on the surface of the base material. The production method includes depositing the silver-ion cladding layer on the base material in winding-type continuous coating equipment by a physical vapor deposition method. The antibacterial medical suture has functions of sterilization and bacteriostasis, and silver ions contact with positions of cuts, wounds and needle holes, so that infection prevention and resistance are realized; the antibacterial medical suture further keeps all properties of existing titanium-nickel memory alloy while having an antimicrobial property, is stable in chemical property, and can meet the requirements on stitching of infected wounds and seborrheic cuts; rejection is avoided during long-term in-vivo implantation, mechanical property is not changed, and the purposes of freeness of trauma, hyperplasia and in-vivo foreign matters are achieved.

The invention discloses a traditional Chinese medicine composition for treating lumbar and cervical spondylosis. The traditional Chinese medicine composition is prepared from the following raw materials: radix aconiti, radix aconiti agrestis, nux vomica, raw excrementum pteropi, rhizoma pinelliae, mastic, myrrh, raw rhubarb, angelica, radix astragal, safflower, walnut meat, brazilwood, lignum acronychiae, cinnamon, flos caryophylli, rhizoma drynariae, radices dipsaci, cortex eucommiae, tuberculate speranskia herb, herba lycopodli, asarum, rhizoma sparganii, radices zedoariae, long-noded pit viper, scorpion tail, large centipede, large ant black ant and pangolin. With the composition, the healing rate of lumbar spondylosis, in particular lumbar intervertebral disc protrusion and cervical spondylosis can reach 99 percent; the diseases can be alleviated for one-hour treatment and can be healed through treatment for eight times; and the composition has the characteristics of rapid curative effect and high healing rate. The composition is prepared from traditional Chinese medicines, has no hormone, no anaesthetic, no wound, no pain in treatment, no toxicity, no side effect, safety and no danger in treatment.

The invention relates to an arterial puncture system and a method for determining an arterial puncture position. The arterial puncture system is provided with a surgical bed, mechanical arms, a braking device, an arterial detection device, a skin disinfection device, an arterial fixation device, a puncture needle operation device, an arterial pressing device and a control platform, and the controlplatform includes an image acquisition and analysis module, an image reconstruction module, a mechanical arm control module, a position collection module, a braking module, an arterial detection module, an arterial puncture module and an arterial hemostasis module. The method for determining the arterial puncture position is completed by using the arterial puncture system. Human body imaging, human body contour recognition, pulse-induced skin pressure change and the like are organically combined, a relationship between pulse wave conduction velocity and blood vessel wall hardness is utilizedto eliminate arterial diseases, and the complete fully-automated precise positioning arterial puncture system with practical operability is constructed.

The invention discloses a fishing two-endoscope one-wire combined minimal invasive liver protection internal and external bile duct calculus crushing and removing method, and relates to medical instruments. The method is used for solving the problems that an existing calculus removing mesh basket touches the inner wall of a bile duct, pain, a wound and bleeding are easily caused in an operative process, and bile duct calculus removal, irrigation, radiography and dilation cannot be integrated. The method comprises a calculus removing mesh basket, a choledochoscope and a laparoscope, the calculus removing mesh basket comprises a catheter, a hollow guide head and mesh baskets, the guide head is positioned at the left end of the catheter, the mesh baskets are positioned on the guide head and include at least two first mesh baskets and at least two second mesh baskets, the catheter comprises an outer tube, a sliding tube, an inner tube and a sliding connector which are arranged from outside to inside, the sliding connector comprises a first terminal, a second terminal and a connecting shaft, and the connecting shaft is used for connecting the first terminal with the second terminal. By the design of the closed mesh baskets, the calculus removing mesh basket cannot touch the inner wall of the bile duct, pain, the wound and bleeding are avoided in the operative process, and bile duct calculus removal, irrigation, radiography and dilation can be integrated.

The invention discloses a positioning method for a craniomaxillofacial surgery. The positioning method comprises the following steps of: first, producing an occlusal splint referring tracer according to a plaster model of dentition of a patient; secondly, fixing an occlusal splint in an oral cavity of the patient, performing CT (Computed Tomography) scanning on the patient to obtain CT scanning image data, and segmenting and reconstructing the CT scanning image data through CT image reconstruction software to obtain a triangular mesh model of soft and hard craniomaxillofacial tissues of the patient and the occlusal splint referring tracer; and thirdly, arranging a standard fixing reference frame at the head of the patient, reading a transformation matrix M2 of the occlusal splint referring tracer in a three-dimensional coordinate system of the standard fixing reference frame, solving a transformation matrix M of the standard fixing reference frame in the three-dimensional coordinate system of the head, solving a transformation matrix Mf of a light-reflecting ball array of a tool in the three-dimensional coordinate system of the head, tracing and navigating the light-reflecting ball array of the tool relative to the three-dimensional coordinate system of the head in real time, and positioning the light-reflecting ball array of the tool.

The invention discloses a manufacturing method of a surgical guide template for an oral cavity planting operation, comprising the following steps of taking a patient oral cavity inner impression; duplicating a plaster model; determining planting positions according to agomphosis gaps, alveolar bone width and the like; marking at a fixed point by utilizing a ball drill; fixing a wax wire with the diameter of 2.5 mm at a fixed point marked part; then filling an agomphosis region by utilizing self-solidifying plastic; covering partial buccal labial surfaces, occlusal surfaces and tongue palatal surfaces of adjacent 1-2 teeth; after the self-solidifying plastic is cured, taking off the template; and washing off the wax wire by utilizing warm water to form a planting path. According to the manufacturing method, the accuracy and the precision of the planting are guaranteed, the conditions that the position and the direction of the planting path are not good due to post-drilling of the traditional surgical guide template so that the position and the direction of a planted body are not good, and the functions and the aesthetics of a planting body long term are failed are avoided. The manufacturing method disclosed by the invention is simple and convenient, is economical, is strong in practical applicability, is noninvasive, easily obtains materials, and is easy to master and high in accuracy.

The invention discloses a plantar reflection area treatment instrument with an Internet-of-Things function. The plantar reflection area treatment instrument comprises a case, a reciprocating mechanism, a rotating mechanism, a massaging head, a foot positioning device and a control system, a cavity is arranged in the case, the reciprocating mechanism is arranged in the lower section of the cavity of the case, the rotating mechanism is arranged above the reciprocating mechanism which drives the rotating mechanism to be in up-down reciprocating motion, the massaging head is connected with the reciprocating mechanism and / or the rotating mechanism, the foot positioning device is arranged at the top of the case, a massaging head opening for exposing the massaging head is arranged on the case and / or the foot positioning device, and the control system is electrically connected with the reciprocating and / or the rotating mechanism and / or the foot positioning device. The plantar reflection area treatment instrument has the Internet-of-Things function and can transmit treatment information to a cloud server, personalized customizing of treatment modes can be realized, and health management and health interference are realized. The plantar reflection area treatment instrument can mechanically stimulate planta pedis, can realize photothermal stimulation of planta pedis and is free of trauma, suffering and side effect during treatment, reliable in treatment effect, simple and reasonable in structure and diverse in function.

The invention provides a digital design and 3D printing method for a personalized pressure mask. The method comprises the steps of 1, operating to acquire point cloud data; 2, importing the point cloud data into digital design to acquire a preliminary three-dimensional mask model; 3, importing an STL format file of the three-dimensional mask preliminary mode into 3-MATIC software for repairing, then performing digital design in GEOMAGIC STUDIO software to acquire a finished three-dimensional mask model, and storing as the STL format file; 4, importing the STL format file of the finished three-dimensional mask model into MAGIC software to perform digital design and well adjusting a printing parameter; and 5, copying the file of the mask model to be printed into a 3D printer for printing to acquire the personalized pressure mask. The method provided by the invention is safe in data collection, quick in speed and simple in design process; the printed pressure mask is portable, high in matching degree with a user and good in effect.

The invention relates to a three-dimensional ultrasonography-based early liver cancer diseased tissue target detection method. The method comprises the following steps of: (1) scanning a three-dimensional ultrasonic reconstruction C surface by using a free arm; (2) scanning a target by a coordinate displacement method or a sector scanning method, and observing the C surface of an image in a minimum three-dimensional reconstruction mode; (3) amplifying and observing the shape, brightness, distribution condition and internal structure of an actual image of the target; (4) effectively reflecting the valuable ultrasonographic information in a three-dimensional mode; and (5) enabling the display precision of the image of the target to reach 0.1 millimeter-scale level sampling thickness. The three-dimensional ultrasonography-based early liver cancer diseased tissue target detection method has the advantages that: the imaging mode breaks through the limit of the action of an ultrasonic physical principle, a diseased tissue of which the minimum size is about 0.1mm can be observed, and an effect similar to a microscopic observation effect is achieved; a brand new image structure is generated to ensure that the information content of an ultrasonic image is greatly enriched and the objectivity and accuracy of image analysis are obviously improved; and the method lays a novel important basis for early diagnosis and treatment of various liver diseases.

The invention discloses a cerebral hemorrhage and cerebral ischemia distinguishing system based on non-contact magnetic induction. The cerebral hemorrhage and cerebral ischemia distinguishing system comprises a signal generator, a power amplifier, a transmitting coil, a receiving coil, a data collection card and a computer. The transmitting coil and the receiving coil are square, are the same in size and are parallel. A detected head is placed in the space of the middle of the two coils. Signals output by the receiving coil and reference signals output by the signal generator are connected to the two input ends of the data collection card. The electric conductivity of the detected head can be reflected by measuring the phase difference between the signals at the two input ends of the data collection card. Due to the fact that the direction of integrated brain electric conductivity changes caused by cerebral hemorrhage is opposite to the direction of integrated brain electric conductivity changes caused by cerebral ischemia, the cerebral hemorrhage and cerebral ischemia distinguishing system achieves non-contact novel magnetic induction detection, and is free of wounds, easy and convenient to use and capable of achieving rapid measurement.

The invention discloses a traditional Chinese medicine composition for treating sinusitis. The medicine composition is prepared from the following components: 120 to 150g of scutellaria, 120 to 150g of gypsum, 50 to 80g of radix bupleuri, 120 to 150g of honeysuckle, 120 to 150g of radix sileris, 120 to 150g of fructus viticis, 180 to 220g of fried fructus xanthii, 120 to 150g of angelica, 50 to 80g of flos magnoliae liliflorae, 50 to 80g of herba centipedae, 50 to 80g of chrysanthemum, 50 to 80g of bombyx batryticatus, 50 to 80g of scorpio, and 120 to 150g of licorice. The medicine composition has the functions of dispelling wind and dispersing dampness, detoxicating and resolving a mass, unblocking orifice and stopping pain, and treating chronic rhinitis, sinusitis and allergic rhinitis. The formulation has the advantages of good curative effect, economy, no trauma and no obvious toxic and side effects, and easily cures the sinusitis.

The invention discloses a test strip for fast detecting premature rupture of fetal membranes, which is formed in a way that a sample pad, a glass fiber membrane, a coating membrane and absorbent paper are sequentially overlapped and pasted on a substrate, wherein the glass fiber membrane is coated with a high-specificity monoclonal antibody of latex particle-labeled insulin-like growth factor binding protein-1 (IGFBP-1); and the coating membrane comprises a detection area coating an anti-IGFBP-1 specific monoclonal antibody and a control area coating an anti-mouse antibody. Compared with the radioimmunoassay method and the enzyme-linked immunosorbent assay (ELISA) method, the test strip disclosed by the invention has the advantages of operational safety, fast detection and the like, is simple and convenient and is applicable to individual detection. The test strip disclosed by the invention can be conveniently and fast operated by people without professional skills, can not cause damages and can realize timely on-site and household self detection of premature rupture of fetal membranes; and the result can be read easily.

The invention relates to a test paper for detecting allergen-specific IgE antibody in a tear sample. The pH value of the test paper is 6.4-7.7, and the test paper is composed of an absorbent pad, a sample pad, a colloidal gold reagent pad, a cellulose membrane, an adhesive layer, a polystyrene baseboard and two toughened glass side boards, wherein the adhesive layer is fixedly arranged on the polystyrene baseboard; the cellulose membrane, the absorbent pad and the colloidal gold reagent pad are fixedly arranged on the adhesive layer; the cellulose membrane is provided with a quality control line and a detection line; the sample pad is arranged on the colloidal gold reagent pad; and the two toughened glass side boards are symmetrically and fixedly arranged at two sides of one end of the test paper provided with the absorbent pad. An advanced allergen immunochromatography technique is adopted to qualitatively determine the specific IgE antibody in the tear sample in order to detect the tear sample, and the test paper has the advantages of noninvasiveness and harmlessness to human bodies, high sensitivity, strong specificity, convenient detection and simple convenient, can complete full detection within 10-15min, is convenient to popularize and use, and can well meet needs of practical application.

The invention provides a hepatitis B microRNA molecular marker composition and application thereof in preparing a hepatitis B infection diagnosis and / or prognosis evaluation kit. The hepatitis B microRNA molecular marker composition comprises more than one microRNA molecule as shown in SEQ NO. 1-18. The invention also provides a diagnostic kit for instructing the infection diagnosis and / or prognosis evaluation of hepatitis B. The hepatitis B microRNA molecular marker and the diagnostic kit which are provided by the invention have the characteristics of easiness for operation, safety, no injury, high specificity, high sensitivity and easiness for large-scale screening in instructing the infection diagnosis and / or prognosis evaluation of a hepatitis B patient.

The invention relates to an early-stage diagnosis marker for an aorta disease and application thereof. The application mainly relates to the fact the lumican serves as the early-stage diagnosis marker for the aorta disease in preparation of an early-stage diagnosis reagent for the aorta disease. The early-stage diagnosis marker for the aorta disease and the application of the marker has the advantages that blood serum lumican detection to a chest pain patient is fast in detection process, economical in detection cost and wound-free to the patient.

The invention discloses an intelligent detection system for gastrointestinal hemorrhage, belonging to the technical field of medical appliances. The intelligent detection system comprises a micro gastrointestinal blood color detection device, a bleeding point positioning device, an in-vitro data storage device and a gastrointestinal bleeding diagnosis analysis system, wherein the micro gastrointestinal blood color detection device enters the gastrointestinal tract by being taken orally and is applied to noninvasive detection and wireless emission of gastrointestinal hemorrhage amount information; the bleeding point positioning device is used for detecting the in-vivo position information of the micro gastrointestinal blood color detection device and transmitting the in-vivo position information to the in-vitro data storage device through a lead; the in-vitro data storage device is used for receiving and storing the gastrointestinal hemorrhage amount information transmitted by the micro gastrointestinal blood color detection device and the position information transmitted by the bleeding point positioning device; and the gastrointestinal bleeding diagnosis analysis system is used for reading and processing data stored in the in-vitro data storage device. The intelligent detection system can be used for detecting in a painless and noninvasive way without performing gut purge, and physiological parameters such as the pH, pressure and the like of the gastrointestinal tract of a human body do not influence the detection result.

The invention relates to a method utilizing event-related potentials equipment to assist in screening mild cognitive impairment. The method adopts the event-related potentials technology to assist in screening mild cognitive impairment (MCI) and judging clinical intervention effect, adopts the learning-recognizing experimental mode to allow a testee to learn and recognize three emotional faces (positive, neutral and negative) during operation, and also utilizes event-related electrocortical potentials equipment to record the electroencephalogram of the testee. Collected data are calculated according to the unique algorithm, so that four indexes, such as the response accuracy, the N170 ingredient, the early-stage old / new effect and the late-stage old / new effect of the testee, become effective indexes for recognizing MCI, and the method is used for early-stage diagnosis and curative effect determination of MCI, is noninvasive, can be easily accepted by patients and is suitable for clinical popularization.

The invention provides a colorectal cancer microRNA molecular marker combination which comprises more than one microRNA nucleic acid molecule selected from: miR-21-3p, miR-877-5p, miR-181d, miR-202-3p, miR-19b-3p, miR-380-5p, miR-1246, miR-627, miR-451a, miR-339-5p, miR-520e, miR-21-5p and miR-532-3p, as well as application to preparation of a colorectal cancer diagnostic kit, and the colorectal cancer diagnostic kit. The comparison between the content of microRNA molecular markers of a colorectal cancer patient in plasma / serum and the content of microRNA molecular markers of colorectal polyppatient and health comparison in plasma / serum shows a great difference. The molecular marker used for guiding diagnoses has the characteristics of high sensitivity, high specificity and the like.