The invention provides an in-vitro distal blood-supply device for free skin flap for plastic surgery. The device comprises a vein puncture needle, a first catheter, a precision peristaltic pump, a second catheter, a venous skin flap anastomosis needle, an arterial puncture needle, a third catheter, a three-way head, a fourth catheter, a precision syringe pump, a replaceable filter cartridge structure, an arterial skin flap anastomosis needle, a heating box, a circulating copper tube, a disassembly tube, a constant temperature water tank, a water pump, a disassembly and fixing belt structure, an auxiliary traction storage board structure, an auxiliary support plate structure, a fifth tube and a sixth tube, and the vein puncture needle is inserted at the upper end of the first catheter. Thedevice has the beneficial effects that through the arrangement of the replaceable filter cartridge structure, when a plug-in board frame is pulled or pushed, different filter screens can be correspondingly connected with a communication tube, during use, the filter screen can be replaced for use, and the influence of easy obstruction of the single filter screen is avoided.