316 results about "Target vessel" patented technology

An apparatus for performing anastomosis between a graft vessel and a target vessel may include a connector holder having spaced-apart arms, and a member connected to the connector holder, where the member is insertable through an opening in a wall of the target vessel at least partially into the lumen of the target vessel. One or more connectors, such as staples, may be deployed from each arm to connect the graft vessel to the target vessel. One or more connectors may be deformable against the member.

An anastomosis system and method uses an anvil to control and support a tissue site during an anastomosis procedure. The anvil is particularly useful for supporting a wall of a coronary artery during attachment of a graft vessel to the coronary artery because the wall of the coronary artery is very thin, difficult to grasp, and susceptible to tearing. In one method, the anvil is inserted into a pressurized or unpressurized target vessel and is pulled against an inner wall of the target vessel causing tenting of the thin tissue of the vessel wall. A graft vessel is then advanced to the anastomosis site and an end of the graft vessel is positioned adjacent and exterior of the target vessel. Staples are inserted through the tissue of the graft vessel and the target vessel by pivoting the arms of a staple holder towards the anvil. When the ends of the staples engage staple bending features on the anvil, the ends of the staples bend over securing the graft vessel and target vessel together. After stapling is complete, an incision is formed in the wall of the target vessel to allow blood flow between the target vessel and the graft vessel.

A vascular interventional device may be introduced over a guidewire into a vessel of the cardiovascular system of a patient. This device includes a hollow, flexible tube having a proximal end and a distal end that is adapted to selectively engage a target vessel of the cardiovascular system of the patient. This tube also includes a lumen that is continuous from the proximal to the distal end, and has an end hole in the distal end that is in fluid communication with the lumen. A plurality of side holes are provided near the distal end of the tube, each of which is in continuous fluid communication with the lumen. The device also includes a hollow vessel dilator that is adapted for insertion into and through the tube and over the guidewire. The dilator has an inside diameter that is slightly larger than the guidewire and an outside diameter that is slightly smaller than the diameter of the lumen of the tube. The distal end of the dilator is adapted to accommodate vascular entry over the guidewire, and the dilator is adapted to dilate the vessel to accept the tube. The device also includes a hub at the proximal end of the tube. The hub includes an end port through which a second interventional device having an outside diameter smaller than the diameter of the lumen may be introduced into the lumen of the tube. The hub also includes a side port through which a fluid agent may be injected for delivery through the lumen and out the end hole and side holes of the tube. A sealing mechanism is also provided in the hub to prevent air from entering the tube and blood and other fluids from leaking out of the tube through the hub. A pair of vascular interventional devices, at least one of which is constructed according to the invention, may be utilized to treat or study a cardiovascular condition, or to measure the blood pressure across a vascular segment.

A vascular interventional device may be introduced over a guidewire into a vessel of the cardiovascular system of a patient. This device includes a hollow, flexible tube having a proximal end and a distal end that is adapted to selectively engage a target vessel of the cardiovascular system of the patient. This tube also includes a lumen that is continuous from the proximal to the distal end, and has an end hole in the distal end that is in fluid communication with the lumen. The device also includes a hollow vessel dilator that is adapted for insertion into and through the tube and over the guidewire. The dilator has an inside diameter that is slightly larger than the guidewire and an outside diameter that is slightly smaller than the diameter of the lumen of the tube. The distal end of the dilator is adapted to accommodate vascular entry over the guidewire, and the dilator is adapted to dilate the vessel to accept the tube. The device also includes a hub at the proximal end of the tube. The hub includes an end port through which a second interventional device having an outside diameter smaller than the diameter of the lumen may be introduced into the lumen of the tube. The hub also includes a side port through which a fluid agent may be injected for delivery through the lumen and out the end hole of the tube. A sealing mechanism is also provided in the hub to prevent air from entering the tube and blood and other fluids from leaking out of the tube through the hub. A pair of vascular interventional devices, at least one of which is constructed according to the invention, may be utilized to treat or study a cardiovascular condition, or to measure the blood pressure across a vascular segment.

A dual mode handheld ultrasonic device is provided for guiding a venous access catheter into a patient's peripheral vein. It provides B-mode imaging with a predetermined aperture and operating frequency which locates and displays a gray scale cross-sectional image of the target blood vessel. A single doppler beam in a separate mode detects the same blood vessel and creates a single scanline image superimposed to such B-mode cross-sectional image. Simultaneously, the intensity of the positive doppler shift detected by the single doppler beam as it hits the target blood vessel activates a plurality of light emitting diode (LED) indicator lights with varying voltage requirements mounted in the scanhead. Activated LED indicator lights forms an arrow pointing inferiorly perpendicular to the target vessel which guides a physician or a paramedical professional to the precise catheter insertion spot on a patient's extremity while simultaneously viewing the target blood vessel's cross-section on the display screen.

Methods and devices for placing a conduit in fluid communication with a target vessel and a source of blood, such as the aorta or a heart chamber. The device may be actuated using one hand to place the conduit. The invention allows air in the conduit to be removed prior to placement of the conduit. The invention deploys the conduit in the target vessel by moving a sheath in a distal direction and then in a proximal direction. A conduit is provided with a reinforcing member to prevent kinking of the conduit, and a structure for preventing blockage of the conduit by tissue. A vessel coupling may be used to secure a conduit to a target vessel so as to preserve native blood flow through the vessel, and the conduit may be placed in fluid communication with a target vessel via a laparoscopic or endoscopic procedure.

Devices and methods for delivering stents to target vessel regions, including stent delivery through microcatheters to narrow cerebral arteries. One stent delivery device includes a stent having the distal region everted over the distal end of a delivery tube, having the everted stent distal end captured by a distal element of a elongate release member disposed through the delivery tube. The delivery tube can have a distal taper to a small profile distal end. The everted stent distal region can be captured between the release member distal element and the surrounding delivery tube distal region walls. The captured and everted stent can be distally advanced to a target site, followed by manipulating the release member to free the captured stent. Some devices utilize distal advancement of the release member while other devices use proximal retraction of the release member to free the captured stent distal end. Once released, the stent is free to self-expand or be expanded against the surrounding blockage and/or vessel walls. In some methods, a guide catheter or microcatheter is also included and disposed about the everted and captured stent to advance the stent, delivery tube, and release member to a location near the site to be stented. The devices and methods provide stent delivery not requiring an enclosing delivery sheath about the stent. The everted stent can thus have a very small distal profile enabling small diameter vessels to be crossed and treated.

Methods and devices for forming an anastomosis during a bypass procedure utilize a graft vessel secured to a vessel coupling adapted to be fixed to a target vessel without using suture. The graft vessel is placed in fluid communication with a heart chamber containing blood. The vessel coupling may be collapsed for introduction into the target vessel and then expanded to fix the coupling thereto. The vessel coupling may be a stent with the graft vessel secured thereto to form a stent-graft assembly. The anastomosis is carried out to place the graft and target vessels in fluid communication while preserving native proximal flow through the target vessel, which may be a coronary artery. As a result, blood flowing from the aorta and past an obstruction in the coronary artery is not blocked by formation of the anastomosis; rather, such proximal blood flow is free to move past the vessel coupling and the anastomosis.

The present invention provides an improved method for reducing the risk or severity of restenosis following cardiac angioplasty. The method includes administering to a target vessel region, a morpholino antisense compound having uncharged phosphorus-containing backbone linkages, and spanning the start codon of a human c-myc mRNA. Also disclosed are novel antisense compounds and compositions, and a method for assaying the effectiveness of antisense delivery and uptake to a target vessel region.

A prosthetic assembly for repairing a target tissue defect within a target vessel region configured includes an exclusion structure sized to substantially bypass target tissue defect, and includes a branch assembly. The branch assembly can include a self-expanding outer branch prosthesis having an inflow region configured to deform to a non-circular cross-sectional-shape when deployed, and a support structure at least partially disposed within the inflow region. The support structure preserves blood flow to the branch vessel while the deformed inflow region inhibits blood leakage between and/or around the prosthetic assembly.

Endoluminal prosthetic devices having fluid-absorbable compositions for repair of vascular tissue defects, such as an aneurysm or dissection, are disclosed herein. A prosthesis for repairing an opening or cavity within a target vessel region configured in accordance herewith includes a tubular body sized to substantially cover the opening or cavity, and having channels formed in a wall thereof. The channels can include a fluid-absorbable composition deposited therein and which is configured to absorb fluid (e.g., blood) and swell within the channels, thereby providing radial expansion of the tubular body in situ.

Methods and devices for forming an anastomosis utilize a graft vessel secured to a vessel coupling that is fixed to a target vessel without using suture. The vessel coupling may be collapsed for introduction into the target vessel and then expanded to engage the vessel wall. The vessel coupling may be a stent attached to a graft vessel to form a stent-graft assembly. The anastomosis may be carried out to place the graft and target vessels in fluid communication while preserving native proximal flow through the target vessel, which may be a coronary artery. As a result, blood flowing through the coronary artery from the aorta is not blocked by the vessel coupling and thus is free to move past the site of the anastomosis.

The inventive apparatus may be inserted into a guiding catheter or other thru-lumen catheters and tubing to assist in navigating and placing the distal end of the guiding catheter or other thru-lumen catheters and tubing at a target location within a patient, by utilizing an externally applied magnetic field to align a plurality of magnetically responsive elements on the apparatus towards the target location. The guiding catheter or other thru-lumen catheters and tubing is then advanced and guided by the apparatus, which facilitates access of the guiding catheter or other thru-lumen catheters and tubing to the target vessel to save time during the catheter placement procedure. The apparatus in combination with magnetic navigation also provides support to hold the guiding catheter or other thru-lumen catheters and tubing in place to resist back out of the catheter.

Some embodiments relate to endoluminal prostheses having a first stent portion and a second stent portion, a main graft body comprising first, second, and third portions, the second portion having a cross-sectional size that is significantly larger than a cross-sectional size of the first or third portions, and also significantly larger than a cross-sectional size of the target vessel. In some embodiments, the first portion of the main graft body can be attached to the first stent portion and the third portion of the main graft body can be attached to the second stent portion. The prostheses can be configured such that the second portion of the main graft body is not directly attached to the first stent portion, the second stent portion, or any other internal support structure. In some embodiments, one or more openings can be formed in the second portion of the main graft body.

Expandable emboli filter and thrombectomy devices adapted for use with microcatheters to remove debris from blood vessels. The devices embody expanded profiles that span the entirety of various sized target vessels and thus are particularly effective in the engagement of debris found in vessels.

The present invention provides a semi-automated method for three-dimensional ultrasound for constructing and displaying 3-D ultrasound images of luminal surfaces of blood vessels. The method comprises acquiring a 3-D ultrasound image of a target vessel and segmenting the luminal surfaces acquired from the 3-D ultrasound image of the target vessel to generate a 3-D ultrasound image of the lumen of the target vessel, wherein an inflating balloon model is used for segmenting the luminal surfaces of the target vessel. The method is useful for diagnostic assessment of bodily vessels as well as provides for therapy planning and as a prognostic indicator.

Vessel wound closure systems and method for sealing a puncture wound in a target vessel, such as those puncture wounds that occur from prior interventional procedures. A sealing member is deployed intravascularly into the target vessel, and an anchor member is deployed extravascularly of the target vessel. The sealing member and the anchor member are connected by a suture that may be drawn to tighten the sealing member and the anchor member relative to one another in order to effect the seal of the puncture wound. After tightening, the suture is secured to maintain the sealing member and the anchor member relative to one another in order to maintain the seal. Preferably, the anchor member, the suture and the sealing member are comprised of biocompatible, bioresorbable materials that are absorbed into the body after the sealing of the puncture wound has been achieved. The sealing member, suture and the anchor member are delivered by a delivery rod or other components over a guidewire or through an introducer already in place from the preceding interventional procedure.

A coronary artery bypass graft procedure is performed through one or more openings made in the patient to create a point of entry to the thoracic cavity. A vein measurement device measures the distance between the proximal and distal anastomotic sites for each graft. A proximal anastomosis tool splits to release a graft vessel after deploying an anastomosis device at the proximal anastomosis site. The tool may be articulated. An integrated stabilizer stabilizes one or more tools relative to the surface of the beating heart at a distal anastomotic site. A distal anastomotic tool may be provided as part of the integrated stabilizer, and connects one end of the graft vessel to a target vessel. An epicardial dissector may be provided as part of the integrated stabilizer, and dissects the epicardium from the target vessel at a distal anastomotic site, as needed.