467 results about "Aorta" patented technology

Apparatus and methods are described including a ventricular assist device that includes a tube configured to traverse a subject's aortic valve. The tube defines a generally-cylindrical central portion, and a proximal conical portion that narrows from a proximal end of the central portion to a proximal end of the tube. The tube defines one or more blood inlet openings in a vicinity of a distal end of the tube, and one or more blood outlet openings that extend axially from the central portion of the tube at least partially into the proximal conical portion of the tube. A blood pump pumps blood into the tube from the subject's left ventricle through the one or more blood inlet openings, and from the tube into the aorta through the one or more blood outlet openings. Other applications are also described.

The invention relates to the field of physiological status real-time monitoring, provides a virtual patient physiological status real-time monitoring method and system based on digital twinning, and is used for solving the problems of non-linear combination deviation and multi-source data synchronization lag of virtual patient physiological status monitoring caused by dependence on a static model and one-way feedback. The method comprises the steps that a valve three-dimensional model is built based on aorta CT data, and a simulation model containing motion conditions is built in combination with a fluid mechanics equation; the blood flow pressure difference and vortex parameters of valve opening and closing are calculated in real time, an optical fiber virtual sensor is embedded in the topological surface of the valve to simulate blood flow deformation, and a valve state mechanical signal is output; parameters and signals are input into a digital twin engine, particle trajectories and refractive indexes are adjusted to generate a visual interface, blood flow velocity-pressure gradient spatio-temporal data are extracted, model boundary conditions are reversely corrected, and valve movement is synchronized with the physiological state of a patient. According to the technical scheme, heart valve movement is simulated in real time, and the real heartbeat rhythm of the patient is automatically matched.

Apparatus and methods are described including delivering a left-ventricular assist device to a subject's aorta. The device including a distal-tip element that defines a straight proximal portion, and a curved distal portion, the curved distal portion defining first and second curves with an elongated straight portion between the first and second curves. The distal-tip element is centered with respect to the aortic valve using the curved distal portion of the distal-tip element, to thereby guide the device through the subject's aortic valve atraumatically. A pump pumps blood through from the subject's left ventricle to the subject's aorta. Other applications are also described.

A normothermic perfusion circuit can be used to perfuse a donor heart after transportation and before transplantation. The circuit can drain the organ storage container of cold preservation solution, perfuse the aorta of the heart with warm fluid to initiate heart activity, and then perfuse the left atrium of the heart with warm fluid to bolster heart activity and evaluate heart viability. Heart viability can be determined using parameters measured by sensors in the circuit.

Apparatus and methods are described including delivering a left-ventricular assist device to a subject's left ventricle. A tube is positioned such that a proximal portion of the tube traverses an aortic valve of the subject, and a distal portion of the tube is disposed within a left ventricle of the subject. A pump pumps blood through the tube from the subject's left ventricle to the subject's aorta such as to cause the proximal portion of the tube to be maintained in an open state, and to cause at least a portion of the tube to become curved. Other applications are also described.

A normothermic perfusion circuit can be used to perfuse a donor heart after transportation and before transplantation. The circuit can drain the organ storage container of cold preservation solution, perfuse the aorta of the heart with warm fluid to initiate heart activity, and then perfuse the left atrium of the heart with warm fluid to bolster heart activity and evaluate heart viability. Heart viability can be determined using parameters measured by sensors in the circuit.

An intravascular blood pump includes a pump housing having an input port and an output port. A relatively short intake cannula may draw blood in through an intake port and deliver the blood to the input port of the pump housing. The intake cannula is relatively short, to prevent excess hydraulic loss. An outflow hose is connected to the output port of the pump housing, so as to convey blood exiting the output port through the outflow hose in a downstream direction to a discharge port, e.g. into an aorta or other blood vessel. Despite the short intake cannula, the outflow hose longitudinally separates the intake port from the discharge port sufficiently so the intake port and the discharge port remain on opposite sides of a heart valve, despite inadvertent longitudinal shifts of the intravascular heart pump.

The invention provides an aorta morphological characteristic automatic measurement and clinical aid decision-making method and system based on artificial intelligence, and is suitable for three-dimensional medical image analysis of aorta and main branches thereof. The method comprises the steps of image data acquisition and preprocessing, vascular structure automatic segmentation, center line extraction and key point positioning, multi-parameter automatic measurement, risk assessment and clinical aid decision making, data standardization output and system feedback optimization. The corresponding system comprises an image acquisition and processing module, a segmentation module, a center line extraction module, a parameter measurement module, an auxiliary decision-making module, a data output module and a verification optimization module. Through a deep learning model and a morphological calculation means, efficient recognition and quantitative analysis of a vascular structure are realized, and individualized risk suggestions and surgical plans are output based on a statistics and machine learning model. According to the method, the automation, standardization and intelligence levels of blood vessel analysis are improved, and the clinical auxiliary decision-making capability under complex cases is enhanced.

The present invention discloses a pharmaceutical composition comprising a circular RNA and a drug delivery carrier. Compared with traditional linear 1 * siRNA and annular 1 * siRNA, the number of repeated series connection of positive-sense strands is increased to include but not limited to two or more, it is accidentally found that the silence effect is remarkably enhanced, the expression level of the PCSK9 gene can be remarkably reduced, and degradation of mRNA of PCSK9 protein is mediated. The nano-particles are used for delivering oligonucleotide, so that the stability is improved, the immunogenicity is reduced, the effects of lowering cholesterol, reducing aortic plaque load and resisting atherosclerosis are improved, and the nano-particles are safe and free of obvious liver and kidney toxicity and have a wide application prospect in the aspect of preparing medicines for treating hypercholesterolemia and coronary heart disease.

The invention discloses an acute aortic syndrome early warning method, system and device and a storage medium, and belongs to the technical field of medical image processing. The method comprises the steps that an aorta CT image is acquired and preprocessed; generating a CTA image by using the cascade generative adversarial network model; and carrying out key information feature extraction on the CTA image by using a deep learning classification model DenseNet, and outputting an aortic syndrome classification result. According to the method, the high-quality CTA image can be generated without using a contrast agent, the risk possibly generated by contrast agent examination of a patient is reduced, and the method is particularly suitable for patients with renal function impairment or contrast agent allergy; compared with the prior art, an economical and efficient alternative scheme is provided, dependence on traditional CTA examination equipment and professionals is reduced, meanwhile, the accuracy rate and the timeliness rate of early warning of the acute aortic syndrome can be effectively increased, and remarkable clinical application value and social benefits are achieved.

A drive system for achieving supra-aortic access and neurovascular treatment site access includes a guidewire hub configured to adjust an axial position and a rotational position of a guidewire, a procedure catheter hub configured to adjust an axial position and a rotational position of a procedure catheter, a guide catheter hub configured to adjust an axial position of a guide catheter, and an access catheter hub configured to adjust an axial position and a rotational position of an access catheter, the access catheter further configured to laterally deflect a distal deflection zone of the access catheter.

A method and system for performing transseptal extracorporeal membrane oxygenation is disclosed. The method may include puncturing a septum between the right atrium and the left atrium and advancing a catheter system through the puncture and into the aorta. A first portion of the catheter system can remove blood from the patient, in some examples near the inferior vena cava. A second portion can return oxygenated blood to the patient, through the transseptal puncture and into the aorta.

Provided is a pharmaceutical composition, comprising a circular RNA and a drug delivery carrier. It is surprisingly found that compared with conventional linear 1 x siRNAs and circular 1 x siRNAs, increasing the number of tandem repeats in the sense strand to two or more significantly enhances the silencing effect, significantly reduces the expression level of the PCSK9 gene, and mediates the degradation of the PCSK9 protein mRNA. The use of nano-particles for delivering oligonucleotides features improved stability, reduced immunogenicity, improved cholesterol-lowering, aortic plaque load-reducing and anti-atherosclerotic effects, good safety, no significant liver and kidney toxicity, and therefore good prospects in preparing medicaments for treating hypercholesterolemia and a coronary heart disease.

An apparatus includes a communication interface and at least one processor. The processor is configured to obtain a size of a lumen in each of a plurality of aortic zones and first information for each of the plurality of aortic zones based on segmentation results of an aorta and the plurality of aortic zones within the aorta; and visualize the size of the true lumen, the first information, and a ratio between the size of the true lumen and the first information in each of the plurality of aortic zones by using a visualization segment corresponding to each of the plurality of aortic zones.

Modular prosthetic valves are disclosed that may support a customized number of leaflets. e.g., four or more leaflets carried by a support structure, such as a frame or stent, which may be used to replace diseased mitral, aortic, tricuspid, or pulmonary valves.

An aorta intervention catheter device for heart failure comprises a catheter and a bag body arranged at one end of the catheter, an elastic diaphragm is arranged in the bag body, an inner cavity of the bag body is divided into a blood chamber and an air chamber by the elastic diaphragm, the blood chamber is communicated with the catheter, an exhaust assembly is arranged on the bag body, and the air chamber is connected with an air source connector arranged on the bag body; the other end of the catheter is a proximal end, first guide films which are staggered at intervals and inclined towards one side of the proximal end and second guide films which are inclined towards a distal end are arranged on the inner wall of the catheter, and first guide holes and second guide holes which correspond to the first guide films and the second guide films and are communicated with an inner cavity of the catheter are respectively formed in the outer wall of the catheter; the proximal side of the second guide film is provided with at least one set of third guide films which are fixed to the inner wall of the catheter, incline towards the distal end and are tightly attached to each other to be closed. The aorta is directly intervened to enter the heart, and coronary artery blood perfusion is increased in the diastolic period; the left ventricular post-load is reduced in the systolic period, and the heart failure can be more directly treated.

The invention discloses an artificial heart valve near-physiological pulsation fluid external evaluation device and method, and relates to the technical field of heart valve testing.The artificial heart valve near-physiological pulsation fluid external evaluation device comprises a supporting frame, a driving unit, a tested valve installation unit and an artery and peripheral loop unit, the driving unit provides power for liquid flowing, and the tested valve installation unit is used for fixing an artificial heart valve; and a liquid volume assembly and a resistance assembly of the artery and peripheral loop unit can simulate the compliance and resistance of aorta blood vessels and peripheral artery blood vessels, so that the pressure waveform simulation of the systemic circulation loop is more accurate. On the basis of the air cavity, the elastic corrugated pipes with different frequency responses are arranged, the compliance and rebound resilience of the aorta are simulated, a device for rapidly replacing the tested valve is designed, and the mechanical property of the simulated human body aorta is adjusted by adjusting the parameters such as the output frequency and the vibration amplitude of the driving unit; real pressure and flow waveforms under different physiological / pathological conditions are simulated, and a more accurate and convenient detection environment is realized.

The utility model discloses a double-gas-path gas source system and a double-gas-path heart auxiliary system. The double-air-path heart assisting system comprises a pressure generating mechanism which alternately generates positive pressure and negative pressure when working; the first auxiliary device comprises first driven equipment and a first piping pipeline, a pipe body at the farthest end of the first piping pipeline is provided with an inflow channel and an outflow channel, and the first driven equipment is located in the pipe body of the first piping pipeline and corresponds to the outflow channel in position; the second auxiliary device comprises second driven equipment and a second piping pipeline communicated with the second driven equipment; the pressure generating mechanism enables the second driven device to repeatedly expand and contract through the second piping. The detection device is used for acquiring the pressure in the cardiac chamber and the pressure in the aorta; and the control mechanism is used for controlling the pressure generation mechanism to respectively drive the first driven equipment and the second driven equipment according to the corresponding time sequence in a cycle control period according to the pressure signal sent by the detection device.

The invention discloses a donor heart preservation method based on a crystal cardioplegic solution (CC solution) and a UW solution and application of the donor heart preservation method, and belongs to the field of biomedical engineering. The method comprises the following steps: (a) preparing CC liquid; (b) perfusing CC liquid through the aorta at the pressure of 150mmHg for 3-5 minutes to cause cardiac arrest; (c) taking out the heart, and performing secondary perfusion with 2000ml of 4 DEG C UW solution for 8-12 minutes; and (d) immersing the heart into a UW solution for cold preservation, wherein the cold ischemia time is less than or equal to 8 hours. In combination with a CC liquid perfusion step, the protection effect of the cold preservation liquid is remarkably improved by reducing the metabolic rate of cardiac cells; through double perfusion of CC liquid and UW liquid, optimization of metabolic balance and effective inhibition of inflammatory response are realized in the cold storage process of the heart; the invention has the functions of prolonging cold ischemia time and keeping heart cells, and provides a new technical means for long-time cold preservation.

The large-area contact type threaded degradable magnesium alloy aorta blood vessel anastomat comprises a conical inner ring, a conical outer ring and a sleeve outer ring which are sequentially arranged from inside to outside, a blood vessel clamping space is formed between the conical inner ring and the conical outer ring, and the conical outer ring and the sleeve outer ring are in threaded fit. The sleeve outer ring is rotated to adjust the size of the blood vessel clamping space. The blood vessel anastomosis device is simple in structure, reasonable in design and convenient to use, the size of a blood vessel clamping space is adjusted by rotating the conical outer ring and the sleeve outer ring, so that blood vessels are fixed, blood vessel anastomosis is rapidly achieved, meanwhile, the traditional outward turning type end face combination mode is avoided, the contact area between the blood vessels is greatly increased, and blood leakage is prevented.

The present disclosure relates to the technical field of medical instruments. Provided is an aortic endovascular structure and blood flow whole-course remodeling device, comprising a sealing portion and a main body. When the sealing portion is arranged in a first tube portion of the main body, the sealing portion arranged on the inner wall of the first tube portion can seal a vascular rupture or another lesion at the position thereof, thereby preventing the flow of blood. In this way, the aortic endovascular structure and blood flow whole-course remodeling device does not rely on the membrane structure of covered stents in the prior art, and thus has improved durability, and also avoids the risk of membrane structure rupture. As the mesh structure of a mesh portion, especially a braided one, allows the shape of the mesh portion to change when subjected to an external force, the aortic endovascular structure and blood flow whole-course remodeling device has good compliance, enabling shearing and damage to vascular walls to be reduced.

The invention discloses a double-gas-path gas source system, a double-gas-path heart assisting system and a using method. The double-air-path heart assisting system comprises a pressure generating mechanism which alternately generates positive pressure and negative pressure when working; the first auxiliary device comprises first driven equipment and a first piping pipeline, a pipe body at the farthest end of the first piping pipeline is provided with an inflow channel and an outflow channel, and the first driven equipment is located in the pipe body of the first piping pipeline and corresponds to the outflow channel in position; the second auxiliary device comprises second driven equipment and a second piping pipeline communicated with the second driven equipment; the pressure generating mechanism enables the second driven device to repeatedly expand and contract through the second piping. The detection device is used for acquiring the pressure in the cardiac chamber and the pressure in the aorta; and the control mechanism is used for controlling the pressure generation mechanism to respectively drive the first driven equipment and the second driven equipment according to the corresponding time sequence in a cycle control period according to the pressure signal sent by the detection device.

The present application relates to the field of medical devices, and specifically to an aortic valve auxiliary prosthesis for preventing regurgitation, comprising: a main body, which is configured to remain in place in the aorta at the surgical site; and three auxiliary leaflet segments configured to cooperate with the three free segments of the native leaflets of the aortic valve; the three auxiliary leaflet segments are fixed to the main body. The present invention allows the original native leaflets to be retained, and when the native valve is closed, the purpose of improving the prevention of regurgitation is achieved by overlapping and covering the free segments of the native valve, with significant therapeutic effects and stronger targeting. Since the native valve is retained, most of the impact force of blood when flowing is still on the native valve, the reliability requirements for the fixed positioning of the main body are low, and the morphological changes to the native valve are smaller.

Aspects of the present disclosure describe systems and methods for predicting an intra-aortic pressure of a patient receiving hemodynamic support from a transvalvular micro-axial heart pump. In some implementations, an intra-aortic pressure time series is derived from measurements of a pressure sensor of the transvalvular micro-axial heart pump and a motor speed time series is derived from a measured back electromotive force of a motor of the transvalvular micro-axial heart pump. Furthermore, in some implementations, machine learning algorithms, such as deep learning, are applied to the intra-aortic pressure and motor speed time series to accurately predict an intra-aortic pressure of the patient. In some implementations, the prediction is short-term (e.g., approximately 5 minutes in advance).

The invention provides a control method and system of an in-aorta balloon counterpulsation system, and relates to the technical field of medical system control. According to the method provided by the invention, through the pre-trained neural network model, the target cardiac cycle of the target user can be quickly and accurately determined according to the historical electrocardiogram monitoring data of the target user under the condition that the target user has arrhythmia or the electrocardiogram signal quality is poor; according to the embodiment of the invention, the target cardiac cycle of the IABP system is obtained, and then inflation and deflation control of the air bag of the IABP system is realized according to the target cardiac cycle, compared with a mode of controlling the IABP system through electrocardio triggering in related technologies, the method provided by the embodiment of the invention can effectively improve the safety and effectiveness of the IABP system, and the use risk of a user is reduced.

A delivery system and method for delivering a prosthetic heart valve to the aortic valve annulus via a transaortic approach. The system includes a balloon catheter for delivering a balloon-expandable prosthetic heart valve through an introducer from an approach from outside the patient, through a minimally-invasive opening in the chest cavity through an incision in the aorta, and into the aorta and aortic annulus. The balloon catheter includes a flexible, tapered tip just distal of the balloon to facilitate positioning of the prosthetic heart valve in the proper orientation within the aortic annulus. The prosthetic heart valve may be installed over the existing calcified leaflets, and a pre-dilation valvuloplasty procedure may also be utilized.

The limiting expandable aortic valve pipeline comprises an aortic valve preliminary pipeline attached with a collagen fiber coating, and the aortic valve preliminary pipeline comprises a proximal pipeline, a valve connecting pipe and a telecentric pipeline. The invention also discloses a preparation method thereof. The limiting expandable aortic valve pipeline provided by the invention is used for replacing an aortic artificial blood vessel and a Bentall type operation of an aortic valve, and after the artificial bioprosthetic valve declines, the limiting expandable aortic valve pipeline provided by the invention provides a condition for embedding the artificial bioprosthetic valve with the same size as an original valve in an interventional manner, so that the limiting expandable aortic valve pipeline can be used for replacing the Bentall type operation of the aortic valve and the artificial bioprosthetic valve. In this way, after the bioprosthetic valve declines, the valve with the same size as the original valve can be placed in an interventional mode, and the patient does not need to open the chest to replace the bioprosthetic valve with the same size.

Intravascularly delivered blood pumps and associated devices, systems, and methods, are disclosed herein. A method of intravascularly delivering a blood pump in accordance with embodiments of the present technology can include, for example, advancing an elongated delivery dilator through a patient's vasculature such that a first portion of the elongated delivery dilator is externally accessible proximate to the subclavian artery and a second portion of the elongated delivery dilator is externally accessible proximate to the femoral artery. The method can further include attaching the second portion of the elongated delivery dilator to a driveline, which is coupled to a balloon at the opposite end, and then pulling on the first portion of the elongated delivery dilator to move the driveline and the balloon through the patient's vasculature to a target site with the balloon positioned within the aorta.

The utility model discloses an in-aorta balloon and an IAB catheter. The in-aorta balloon comprises a balloon body and a catheter which is located outside the balloon body and connected with the front end of the balloon body. A balloon catheter with the hardness larger than that of the balloon body is arranged in the balloon body. The balloon catheter extends from the front end of the balloon body to the tail end of the balloon body by a preset length; the tail end of the balloon catheter is closed and a plurality of through holes are formed in the surface of the balloon catheter; the inner cavity of the catheter is communicated with the inner cavity of the balloon catheter or the inner cavity of the catheter, the inner cavity of the balloon catheter and the inner cavity of the balloon body are communicated at the same time, and when the front end of the balloon body is sucked to be shrunken, the tail end of the balloon body is sucked to be shrunken through the through holes in the surface of the balloon catheter at the same time. The balloon catheter is arranged, so that rapid deflation of the balloon is achieved, the negative pressure requirements of the rear end driving device and the negative pressure tank are reduced, meanwhile, deflation of the balloon can be accelerated, and the rapid response capacity when the heart rate is high or the heart rate is not stable is facilitated.

Apparatuses and methods for performing transseptal extracorporeal membrane oxygenation are disclosed. The method may include puncturing a septum between the right atrium and the left atrium and advancing a catheter system through the puncture and into the aorta. The catheter system may include coaxially arranged and independently moveable venus and arterial sheaths having independently positionable openings for removing blood from the patient and for returning oxygenated blood to the patient, e.g., within the aorta.