247 results about "Aorta" patented technology

Apparatus and methods are described including delivering a left-ventricular assist device to a subject's aorta. The device including a distal-tip element that defines a straight proximal portion, and a curved distal portion, the curved distal portion defining first and second curves with an elongated straight portion between the first and second curves. The distal-tip element is centered with respect to the aortic valve using the curved distal portion of the distal-tip element, to thereby guide the device through the subject's aortic valve atraumatically. A pump pumps blood through from the subject's left ventricle to the subject's aorta. Other applications are also described.

A normothermic perfusion circuit can be used to perfuse a donor heart after transportation and before transplantation. The circuit can drain the organ storage container of cold preservation solution, perfuse the aorta of the heart with warm fluid to initiate heart activity, and then perfuse the left atrium of the heart with warm fluid to bolster heart activity and evaluate heart viability. Heart viability can be determined using parameters measured by sensors in the circuit.

Apparatus and methods are described including delivering a left-ventricular assist device to a subject's left ventricle. A tube is positioned such that a proximal portion of the tube traverses an aortic valve of the subject, and a distal portion of the tube is disposed within a left ventricle of the subject. A pump pumps blood through the tube from the subject's left ventricle to the subject's aorta such as to cause the proximal portion of the tube to be maintained in an open state, and to cause at least a portion of the tube to become curved. Other applications are also described.

A normothermic perfusion circuit can be used to perfuse a donor heart after transportation and before transplantation. The circuit can drain the organ storage container of cold preservation solution, perfuse the aorta of the heart with warm fluid to initiate heart activity, and then perfuse the left atrium of the heart with warm fluid to bolster heart activity and evaluate heart viability. Heart viability can be determined using parameters measured by sensors in the circuit.

An intravascular blood pump includes a pump housing having an input port and an output port. A relatively short intake cannula may draw blood in through an intake port and deliver the blood to the input port of the pump housing. The intake cannula is relatively short, to prevent excess hydraulic loss. An outflow hose is connected to the output port of the pump housing, so as to convey blood exiting the output port through the outflow hose in a downstream direction to a discharge port, e.g. into an aorta or other blood vessel. Despite the short intake cannula, the outflow hose longitudinally separates the intake port from the discharge port sufficiently so the intake port and the discharge port remain on opposite sides of a heart valve, despite inadvertent longitudinal shifts of the intravascular heart pump.

A drive system for achieving supra-aortic access and neurovascular treatment site access includes a guidewire hub configured to adjust an axial position and a rotational position of a guidewire, a procedure catheter hub configured to adjust an axial position and a rotational position of a procedure catheter, a guide catheter hub configured to adjust an axial position of a guide catheter, and an access catheter hub configured to adjust an axial position and a rotational position of an access catheter, the access catheter further configured to laterally deflect a distal deflection zone of the access catheter.

An apparatus includes a communication interface and at least one processor. The processor is configured to obtain a size of a lumen in each of a plurality of aortic zones and first information for each of the plurality of aortic zones based on segmentation results of an aorta and the plurality of aortic zones within the aorta; and visualize the size of the true lumen, the first information, and a ratio between the size of the true lumen and the first information in each of the plurality of aortic zones by using a visualization segment corresponding to each of the plurality of aortic zones.

The invention discloses an artificial heart valve near-physiological pulsation fluid external evaluation device and method, and relates to the technical field of heart valve testing.The artificial heart valve near-physiological pulsation fluid external evaluation device comprises a supporting frame, a driving unit, a tested valve installation unit and an artery and peripheral loop unit, the driving unit provides power for liquid flowing, and the tested valve installation unit is used for fixing an artificial heart valve; and a liquid volume assembly and a resistance assembly of the artery and peripheral loop unit can simulate the compliance and resistance of aorta blood vessels and peripheral artery blood vessels, so that the pressure waveform simulation of the systemic circulation loop is more accurate. On the basis of the air cavity, the elastic corrugated pipes with different frequency responses are arranged, the compliance and rebound resilience of the aorta are simulated, a device for rapidly replacing the tested valve is designed, and the mechanical property of the simulated human body aorta is adjusted by adjusting the parameters such as the output frequency and the vibration amplitude of the driving unit; real pressure and flow waveforms under different physiological / pathological conditions are simulated, and a more accurate and convenient detection environment is realized.

The utility model discloses a double-gas-path gas source system and a double-gas-path heart auxiliary system. The double-air-path heart assisting system comprises a pressure generating mechanism which alternately generates positive pressure and negative pressure when working; the first auxiliary device comprises first driven equipment and a first piping pipeline, a pipe body at the farthest end of the first piping pipeline is provided with an inflow channel and an outflow channel, and the first driven equipment is located in the pipe body of the first piping pipeline and corresponds to the outflow channel in position; the second auxiliary device comprises second driven equipment and a second piping pipeline communicated with the second driven equipment; the pressure generating mechanism enables the second driven device to repeatedly expand and contract through the second piping. The detection device is used for acquiring the pressure in the cardiac chamber and the pressure in the aorta; and the control mechanism is used for controlling the pressure generation mechanism to respectively drive the first driven equipment and the second driven equipment according to the corresponding time sequence in a cycle control period according to the pressure signal sent by the detection device.

Aspects of the present disclosure describe systems and methods for predicting an intra-aortic pressure of a patient receiving hemodynamic support from a transvalvular micro-axial heart pump. In some implementations, an intra-aortic pressure time series is derived from measurements of a pressure sensor of the transvalvular micro-axial heart pump and a motor speed time series is derived from a measured back electromotive force of a motor of the transvalvular micro-axial heart pump. Furthermore, in some implementations, machine learning algorithms, such as deep learning, are applied to the intra-aortic pressure and motor speed time series to accurately predict an intra-aortic pressure of the patient. In some implementations, the prediction is short-term (e.g., approximately 5 minutes in advance).

The invention provides a real-time monitoring and control method and system for pressure in a catheter in breast duct endoscopy, and relates to the technical field of medical equipment monitoring and control, and the method comprises the following steps: forming a multi-dimensional parameter characteristic matrix by collecting temperature, conductivity and image data in the catheter, and carrying out adaptive filtering analysis to extract fluid characteristic parameters; pressure distribution characteristics in the conduit are calculated, fluid flow state parameters are monitored in combination with a microfluid sensor array to identify a local turbulence area, when the turbulence intensity exceeds an early warning threshold value, wavelet transform is adopted to analyze and calculate the turbulence development trend, and the pressure in the conduit is controlled within a safe range through an active pulsation compensation technology; and the safety and the accuracy of breast duct endoscope examination are improved.

Systems, devices and methods are provided for supporting cardiac function. A device comprises an elongate housing configured for implantation into a patient exterior to the chest cavity. The housing includes a first inlet and an outlet that define a primary blood flow path from the left atrium through at least a portion of the housing within the right atrium, and to the aorta. The housing comprises a motor disposed within the housing and an impeller coupled to the motor for pumping blood from the first inlet to the outlet of the housing through the primary blood flow path. The device bypasses the left ventricle by drawing freshly oxygenated blood from the left atrium and propelling this blood directly into the aorta. Implanting the pump exterior to the chest cavity is less invasive and allows the pump to be quickly and easily repaired, cleaned, repositioned and or replaced without removing or replacing the tubes that are anchored to sensitive tissue structures within the thoracic cavity.

The invention provides a self-adaptive control method and device for a double-ventricle auxiliary system. The method comprises the steps that target aortic pressure detected by a first pressure sensor, target left ventricular end diastolic pressure detected by a second pressure sensor, target right atrial pressure detected by a third pressure sensor and target pulmonary artery pressure detected by a fourth pressure sensor are obtained; and determining a strategy for adjusting the left ventricular assist device or the right ventricular assist device according to the target left ventricular end diastolic pressure, the target right ventricular pressure and the target pulmonary arterial pressure when the peripheral perfusion of the target user is insufficient or the lung is over-perfused. The pressure sensors are arranged to detect the pressure of the inlets and the outlets of the left ventricular assist device and the right ventricular assist device, whether adverse events such as peripheral insufficiency or pulmonary hyperperfusion occur to a user or not is judged according to the detected pressure, and then the adverse events are relieved or even solved by adjusting the rotating speeds of the left ventricular assist device and the right ventricular assist device. And the safety of the user is greatly improved.

The present invention discloses a closure device for mitral valve leaflet repair, which relates to the technical field of mitral valve leaflet repair. The present invention includes an upper jaw assembly, one side of the upper jaw assembly is set to an opening shape, and a positioning clamp assembly is slidably connected to the inner wall of the opening. The end of the positioning clamp assembly is provided with an outer protrusion, and the top of the upper surface of the outer protrusion is provided with a hook-shaped groove. The present invention utilizes the continuous abutment and approach of the closure assembly to finally connect the port with the clamp arm, thereby forming an integrated structure between the closure assembly and the two clamp arms, so that the closure assembly is connected to the bottom of the mitral valve, and the first clamp arm and the second clamp arm are connected to the top of the mitral valve. Therefore, during the systole of the heart, the mitral valve is tightly closed, preventing blood from the left ventricle from flowing back to the left atrium, thereby ensuring that blood can be pumped from the left ventricle into the aorta in the correct direction, and the closure assembly can be closed without relying on external force. Compared with the existing technology, the external operating structure for controlling the turning is saved.

The utility model relates to a large area contact type thread type degradable magnesium alloy aortic blood vessel anastomat, including the conical inner ring, conical outer ring and sleeve outer ring that set gradually from inside to outside, be provided with blood vessel clamping space between the conical inner ring and conical outer ring, it is the thread cooperation between conical outer ring and sleeve outer ring, adjust the size of blood vessel clamping space through the rotation sleeve outer ring, sleeve outer ring. The utility model simple structure, reasonable in design, convenient to use, adjust the size of blood vessel clamping space through the rotation conical outer ring and sleeve outer ring to fixed blood vessel, realize blood vessel anastomosis fast, avoid the mode of the traditional everted type through end face combination simultaneously, greatly increase the contact area between blood vessel and prevent the occurrence of blood leakage.

The present invention provides an auxiliary occlusion device for aortic valve regurgitation. The auxiliary occlusion device comprises a positioning mechanism and an auxiliary occlusion member disposed proximal to the positioning mechanism. When the positioning mechanism is released, it is secured within the aorta, positioning the auxiliary occlusion member between the aortic valves. The auxiliary occlusion device can assist the aortic valve in occluding the gap between the aorta and the left ventricle in the presence of aortic valve regurgitation, thereby reducing or preventing blood backflow through the aortic valve. Furthermore, the auxiliary occlusion device does not obstruct blood flow in the aorta during ventricular contraction.

The invention discloses application of gynostemma pentaphyllum polysaccharide to prevention of vascular wall thickening caused by space microgravity and a medicine, the gynostemma pentaphyllum polysaccharide is applied to prevention of vascular wall thickening caused by space microgravity and the medicine for prevention of vascular wall thickening caused by space microgravity, and the medicine contains the gynostemma pentaphyllum polysaccharide; the gynostemma pentaphyllum polysaccharide reduces thickening of blood vessel walls by inhibiting proliferation and migration of vascular smooth muscle cells, can be used for preventing or treating aorta blood vessel wall thickening caused by space microgravity, and is suitable for health guarantee of astronauts in long-term space missions.

Embodiments of the present disclosure are directed to stents, valved-stents, and associated methods and systems for their delivery via minimally-invasive surgery.

A delivery system for delivering a prosthetic valve in a compressed condition over an inner shaft of a catheter. The delivery system includes a tip extending distally from the inner shaft. The tip has a proximal section and an opposite distal section extending to an end of the tip. The proximal section is configured to support an end of the prosthetic valve during loading and delivery of the prosthetic heart valve and includes a first portion, a second portion, and a third portion. The first portion is adjacent the distal section. The second portion is between the first portion and third portion. The third portion is adjacent a proximal end of the tip. An outer diameter of the first portion is greater than an outer diameter of the inner shaft, an outer diameter of the second portion, and an outer diameter of the third portion.

The invention discloses a staged pump speed regulation and control implementation method for improving VA-ECMO cycle stability, and relates to the technical field of biomedical engineering. The method comprises the following steps: acquiring a real-time aorta pressure waveform, a peripheral artery pressure waveform and an ECMO post-pump pressure waveform of a patient, and extracting pulse wave characteristics, a pressure oscillation amplitude and phase deviation information; calculating a heart-ECMO blood flow intersection collision intensity index and evaluating a heart load state grade; acquiring a vascular compliance estimated value of a patient, and determining a target pump speed adjusting mode and adjusting amplitude according to a hierarchical regulation strategy library; and the current actual pump speed is obtained, a speed regulation decision is made, the ECMO pump is driven to execute graded stepped pump speed regulation, and the regulation speed is dynamically corrected in real time in the regulation process until the cyclic stable interval is reached. Quantitative evaluation and self-adaptive regulation and control of the pump speed are achieved, hemodynamic fluctuation is inhibited, and the stability and safety of VA-ECMO cycle support are improved.

The invention provides a ventricular elasticity value estimation method and device.The method comprises the steps that a first parameter and a second parameter are obtained, the first parameter comprises at least one of target ventricular pressure, target aortic pressure and target pulmonary arterial pressure of a target user, and the second parameter comprises at least one of the target ventricular pressure, the target aortic pressure and the target pulmonary arterial pressure; the second parameter comprises the pumping flow of the target ventricular assist device and the cardiac cycle of the target user; inputting the first parameter and the second parameter into a target decision model, and outputting a target ventricular volume; and estimating a target ventricular elasticity value according to the ratio of the target ventricular pressure to the target ventricular volume. The ventricular volume of the current user is estimated through the decision model, the estimated ventricular elasticity value is calculated according to the ratio of the ventricular pressure to the ventricular volume, and the ventricular elasticity value of the patient can be accurately predicted in real time without depending on ultrasonic equipment.

The invention belongs to the technical field of biological medicine, and particularly provides application of flufenidone in preparation of a medicine for preventing or treating left heart failure. The research finds that the flufenidone has the effects of relieving myocardial cell hypertrophy under a heart failure cell model and relieving myocardial hypertrophy, fibrosis and heart function deterioration of an aortic constriction animal model. According to the present invention, further research results show that fluorofenidone is directly combined with SERCA2a through Q758, D812 and E917 residues of SERCA2a so as to inhibit recognition, combination and polyubiquitination effects of WWP1 on SERCA2a, such that the protein level and the activity of SERCA2a are stabilized so as to achieve the chronic left heart failure treatment purpose. Therefore, the flufenidone serving as an active ingredient has good application prospect and application value in research and development of novel medicines for treating chronic left heart failure.

The invention provides an in-aorta balloon catheter with a thrombus prevention function, and belongs to the technical field of aorta balloon counterpulsation. Comprising an expandable balloon, a first outer catheter is arranged in the center of the interior of the balloon, a thrombus filtering part is arranged at the end, away from the balloon, of the first outer catheter, a third outer catheter is arranged at the other end of the thrombus filtering part, and a connecting part which is arranged outside a body and used for allowing the balloon to be shrunken and inflated and allowing a guide wire to penetrate is arranged on the other side of the third outer catheter. By opening the thrombus filtering part and the filtering umbrella net, small thrombus fragments which are crushed and fall off by the balloon can be filtered and collected in the filtering umbrella net, so that the thrombus fragments are effectively prevented from flowing along with blood, and the small thrombus fragments which are accumulated between the closed filtering umbrella net and the outer catheter II are moved out of a human body along with the outer catheter I and the thrombus filtering part; the fallen small-fragment thrombus can be well removed from the human body, the risk that the small-fragment thrombus flows to the minimum end of a blood vessel along with blood flow to cause embolism is effectively reduced, and the using effect is greatly improved.

This application relates to a blood pump, comprising a primary pumping device, a first catheter, a secondary pumping device, and a second catheter connected in sequence. The primary pumping device has a first inlet and a first outlet, and the secondary pumping device has a second inlet and a second outlet. The secondary pumping device includes a secondary cannula, which has a proximal end, a distal end, and an enlarged portion. The proximal end is adjacent to the second catheter and has a second outlet. The distal end is connected to the first catheter and has a second inlet. The two ends of the enlarged portion are smoothly transitioned to the proximal end and the distal end, respectively. This blood pump increases the blood volume pumped by the secondary pumping device, allowing most of the blood in the aorta to be accelerated by the secondary pumping device, thus significantly improving the pumping efficiency of the secondary pumping device.

The invention relates to the technical field of medical instruments, and particularly discloses a catheter handle, a catheter pump and a catheter pump system. According to the catheter handle, the perfusion liquid inflow connector, the artery pressure measuring liquid inlet connector, the artery pressure measuring liquid outlet connector and the catheter connector are arranged on the perfusion support, the perfusion liquid outflow connector is arranged on the coupling support, the perfusion support and the coupling support are large in size, and therefore the connectors can be conveniently arranged; the number of parts is reduced, so that the machining process of the guide pipe device is simplified; besides, the artery pressure measuring liquid inlet connector and the artery pressure measuring liquid outlet connector are arranged on the perfusion stent, the connectors can be conveniently arranged, an independent aorta pressure sensing channel is formed, and compared with the prior art, flowing of perfusion liquid used for sensing the aorta pressure is not prone to being interfered by other factors, and the perfusate can be used for sensing the aorta pressure. And thus, the aortic pressure sensing precision is improved.

The application discloses an auxiliary instrument for aortic replacement artificial blood vessel surgery, which comprises a collapsible and inflatable bag body which extends into the aorta of a heart to block blood, wherein the bag body is provided with a bag body channel for blood to pass through, and the upper end of the bag body is connected with a drainage tube; the connection end of the drainage tube with the bag body is provided with a drainage tube cavity; the outer side of the drainage tube is provided with a drainage tube through hole for guiding the seepage blood between the bag body and the aorta of the heart into the drainage tube cavity; the drainage tube is respectively provided with a drainage tube channel which is communicated with the bag body channel and is used for sending the blood in the aorta of the heart into an extracorporeal circulation device, an injection channel which is used for injecting or extracting liquid or gas to the bag body so as to make the bag body inflate or shrink, and a seepage blood extraction channel which is used for extracting the seepage blood in the drainage tube cavity; the seepage blood is guided into the drainage tube cavity through the drainage tube through hole, and the seepage blood is extracted through the seepage blood extraction channel, so that the problem of the seepage blood blocking the suture visual field is solved.

The application provides a rotating type artificial mechanical heart valve, and belongs to the technical field of heart valves, and comprises: a valve ring; a valve leaflet group, which is rotationally arranged in the valve ring; when the valve leaflet group is in an open state, a spiral channel is formed in the valve ring; and when the valve leaflet group is in a closed state, the valve leaflet group limits blood flow through the valve ring; the rotating type artificial mechanical heart valve of the application forms a spiral channel with the same rotation direction as the blood rotation flow state when the valve leaflet group is in the open state; the spiral channel is arranged to effectively rotate the blood flow, generate corresponding spiral flow state, and the rotation of the outlet blood flow is beneficial to the full flow and development of the blood flow in the aorta, reduces the turbulence, stagnation area and damage to the normal rotation flow state in the aorta, and the heart valve provided by the application has excellent hemodynamic characteristics and can effectively inhibit the aortic dilation complication caused by aortic valve replacement.

The invention relates to a guide-wire-free integrated balloon catheter system, which comprises a balloon dilatation mechanism, a balloon catheter and a balloon catheter, the balloon dilatation mechanism comprises a first balloon, a second balloon and a balloon pushing rod, and the first balloon and the balloon pushing rod are arranged in a penetrating manner; the first balloon is used for blocking the aorta I region; the second balloon and the balloon pushing rod are arranged in a penetrating manner; the second balloon is used for blocking the aorta III region; a first outlet and a second outlet are respectively formed in the balloon pushing rod between the first balloon and the second balloon and in the other side of the second balloon, and a blood inlet is further formed in the other side of the first balloon; the blood inlet is communicated with the first outlet and the second outlet through a pipeline and is closed or opened through a valve, and the pipeline is located in the balloon pushing rod. The balloon is used for improving the hemostasis and plugging effects, meanwhile, avascular necrosis of internal organs and limbs below the plugging position can be prevented, the balloon can better play the hemostasis, plugging and other roles, and the hemostasis time is prolonged.

An occlusion assembly for occluding the aorta of a patient is presented. The occlusion assembly includes an elongate shaft of two separate extrusions to which an elastomeric balloon envelope is bonded to an end of each. A support wire extends through the elongates shaft and the balloon envelope. At a distal end of the shaft, the support wire is provided with an atraumatic J-tip. At the proximal end of the shaft the proximal end of the support wire is secured to a proximal hub to give the entire assembly sufficient stiffness to be advanced into the vasculature of the patient. The balloon envelope is pre-molded to have a reverse teardrop or “ice cream cone” like shape and will maintain that general shape throughout inflation to the fully inflated state. If the balloon envelope is over inflated, the balloon envelope will advance distally and proximally (lengthening) along the support wire without damage to the surrounding vessel.

A delivery device prevents longitudinal expansion of an aortic prosthesis under compression by engagement of a clutch with a pin upon release of a handle rotating a gearing mechanism about the pin that advances the aortic prosthesis during endovascular implantation at a surgical site.