A preparation method of the invented quick-soluble scaffold for anastomosis of blood vessel includes the following steps: firstly, preparing double-distilled water solution by using dissolvable polymer, heating the above-mentioned solution, quickly stirring and adding physiological salt powder to form ropy compound, using mould to extrude or draw the said compound to make it into claviform or hollow tube which is identical to vassel of human body in diameter so as to obtain the invented soluble scaffold material. This blood vessel scaffold possesses micrometer level porosity in structure, after it is compounded with physiological salt crystal, its mechanical strength is increased, in the course of application, it features proper dissolving time, smooth surface, good elasticity and does not damage endangium, and it is non-toxic, and has no residual. It is quick in anastomosis speed, simple and easy to implement.