113 results about "Vascular wall" patented technology

The invention discloses an artery plaque detection and evaluation method and device, and relates to the technical field of image recognition. The method comprises the following steps: acquiring a to-be-used image group, wherein the to-be-used image group comprises at least one modal magnetic resonance image; performing blood vessel wall segmentation operation on the to-be-used image group to obtain a binary blood vessel skeleton image; inputting the to-be-used image group and the binarized vascular skeleton image into a trained plaque segmentation model to obtain a binarized plaque mask combination; inputting the binarized plaque mask combination and the to-be-used image group into a trained plaque component recognition model to obtain a multi-label segmentation result image; and performing plaque vulnerability judgment according to the multi-label segmentation result image so as to obtain plaque vulnerability judgment information. According to the method, the problems of high subjectivity, poor generalization ability, sensitivity to image quality and the like caused by dependence on artificial feature extraction and threshold segmentation in a traditional method are solved.

Disclosed herein are systems and methods for locating and identifying nerves innervating the wall of arteries such as the renal artery. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The methods includes evaluating a change in physiological parameters after energy is delivered to an arterial wall; and determining the type of nerve that the energy was directed to (sympathetic or parasympathetic or none) based on the evaluated results. The system includes at least a device for delivering energy to the wall of blood vessel; sensors for detecting physiological signals from a subject; and indicators to display results obtained using said method. Also provided are catheters for performing the mapping and ablating functions.

An implantable medical device for closure of a tissue tract / opening in a vessel wall includes a constraint disposed around and constraining the implantable medical device in a constrained configuration and one or more deployment lines attached to the constraint. A flexible hollow body is coupled proximate a midpoint of the implantable medical device. The implantable medical device and flexible hollow body are operable to transition (pivot) from a parallel, side-by-side arrangement to be substantially angled relative to one another. Retracting the one or more deployment lines causes the constraint to release the implantable medical device to transition from the constrained configuration to an expanded configuration.

Methods, systems, devices, components, and apparatuses for renal denervation. The treatment component includes a first sensor configured to detect a first temperature or a first impedance. The treatment component includes a first energy delivery element configured to deliver energy to the vessel wall. The treatment component includes a processor. The processor is configured to determine a heart rate based on the first temperature or the first impedance. The processor is configured to determine that the heart rate is less than a threshold heart rate indicating a slowing of the heart rate. The processor is configured to control the first energy delivery element to regulate the delivery of energy to the vessel wall.

The invention discloses a vascular calcification dynamic monitoring method based on signal pattern recognition, and relates to the technical field of vascular mechanics signal analysis, and the method comprises the steps: obtaining acoustic original data of a target vascular region in a cardiac cycle, completing time synchronization and noise suppression based on a cardiac cycle starting point, and obtaining an acoustic data segment; constructing a displacement sequence changing along with time in the radial depth direction, and extracting amplitude, phase and deformation tracks to form a motion parameter set; arranging the motion parameters according to depths to construct a cardiac cycle response fingerprint matrix, and determining boundary positions of an intima, a middle membrane and an adventitia of a blood vessel wall according to motion mode differences of different depths; local offset features are collected and recognized based on multiple moments, the depth position of calcification in the blood vessel wall is determined, and dynamic monitoring of calcification along with time is achieved. According to the method, continuous presentation of the hierarchical structure of the blood vessel wall and fine expression of mechanical response of multiple layers of tissues are realized, and abnormal changes related to calcification can be sensitively recognized.

Balloon based therapy devices for treatment of diseased vessels with particular applicability to veins are described. The devices are adapted for active aspiration of a closure zone, in particular aspects to an isolated closure zone, prior to delivery of a closure agent. The devices may be used for treatment of diseased veins in the lower limbs and pelvis. The devices may also include a plurality of angular offset abrasion elements adapted to engage with a vessel wall, such as along a treatment zone.

This invention provides a bicuspid aortic valve implantable annuloplasty ring, comprising two symmetrically arranged semi-annular bodies. The two ends of the two semi-annular bodies are connected in a saddle shape by a connecting post, and the connecting post extends upward by a predetermined length, forming the highest point of the annuloplasty ring. At the connection point, the two semi-annular bodies form a first predetermined angle. The semi-annular bodies are made of flexible material, and the connecting post is made of rigid material. This invention can be conveniently implanted into the bicuspid aortic valve annuli and can be operated within the aorta, eliminating the need for dissection outside the vessel wall.

An implantable device for sealing an aperture in a tissue of a body vessel, includes: an external fixation disposed on the outside of a vessel wall; a scaffold disposed on the inside of the vessel wall and interfacing with the external fixation, at least a portion of the scaffold disposed through an aperture in the vessel wall; and a patch disposed on the inside of the vessel wall and sandwiched between the external fixation and the scaffold, the patch substantially covering the full area of the aperture, thereby sealing the aperture.

A cardiac electrode assembly. The inventive electrode assembly includes an active fixation device, such as a helical electrode configured to screw into the myocardium or a vessel wall. The invention also includes an array of two or more reversed tines. The reverse tines bear against the heart wall or vessel wall and inhibit unwanted distal motion of the electrode assembly. Various deployment devices that aid in the installation of the inventive electrode assembly are also described.

The application discloses an aortic dissection risk reverse evaluation method and system, relates to the technical field of cardiovascular disease risk evaluation, and discloses an aortic dissection risk reverse evaluation method and system, which calculates a contradiction coefficient of blood vessel stability and behavior load by integrating medical image data and daily behavior dynamic data, generates early warning information based on the difference, effectively solves the technical problems that a traditional evaluation method cannot dynamically capture mechanical changes of a blood vessel wall and identify potential risk conflicts, can dynamically monitor the contradictory relationship between the geometric stability of a blood vessel and daily behavior load in real time, generates high-risk early warning information in time, avoids the early warning loss caused by too long an examination interval in the traditional evaluation method, and improves the accuracy and timeliness of risk evaluation.

A catheter system for treating a treatment site within or adjacent to a vessel wall includes a light source, a balloon, a light guide, and an optical analyzer assembly. The light source generates light energy. The balloon is positionable substantially adjacent to the vascular lesion. The balloon has a balloon wall that defines a balloon interior that receives a balloon fluid. The light guide receives light energy from the light source at a guide proximal end and guides the light energy toward a guide distal end and into the balloon interior. The optical analyzer assembly is configured to optically analyze light energy emitted from the guide proximal end of the light guide.

Methods, apparatuses and systems for monitoring, including electrically and optically monitoring an aspiration catheter to identify material in proximity to or within the catheter. In particular, described herein are methods and apparatuses that may be used to identify clot material, and to distinguish clot material from blood and / or vessel wall. Also described herein are methods and apparatuses for sizing vessels and identifying side vessels.

To provide a suitable intravascular imaging display system.SOLUTION: An intravascular imaging display system having control circuitry and video output circuitry is provided. The video output circuit is configured to generate a display output including a user interface. The user interface includes a plurality of graphical elements associated with the vessel being imaged. The plurality of graphical elements includes a first detected feature portion defined by a first graphical indicator and a second detected feature portion defined by a second graphical indicator. The first graphic indicator is visually distinct from the second graphic indicator. The first detected feature portion and the second detected feature portion are assigned by the control circuit to indicate one or more locations along the vessel wall based on whether the attenuance of the ultrasound return signal exceeds a threshold.SELECTED DRAWING: Figure 1

The invention discloses a preparation method of a coronary artery microcirculation disturbance animal model, and belongs to the technical field of biological medicine. According to the method, the stable mouse CMD model can be established by injecting 20-40 [mu] g / mL Calcimycin into the cardiac apex for the first time. Calcimycin is a calcium ion (Ca < 2 + >) carrier commonly used in a laboratory and can transport calcium ions outside cells into the cells, so that the concentration of the calcium ions in the cells is increased. Particularly, when 40 [mu] g / mL of Calcimycin is injected, the pathological severity of the Calcimycin is further aggravated, myocardial fiber arrangement is disordered, boundary is unclear, a large number of myocardial cells are necrotic and dissolved, cavitation is formed, vascular wall degeneration swelling is caused, inflammatory cell infiltration is caused, and thrombus is formed in microvessels.

By using a distal element comprising an expandable mesh, retrieval of material from a blood vessel lumen can be improved. A treatment device includes an elongated member having a proximal portion and a distal portion configured to be positioned intravascularly at a treatment site at or near a thrombus. A distal element comprising an expandable mesh is coupled to the distal portion of the elongated member by a connection assembly. In an expanded state, at least a portion of the mesh is configured to be juxtaposed with a vessel wall at the treatment site to anchor or stabilize the elongated member relative to the vessel. The distal element can be electrically coupled to an extracorporeal current generator.

An endovascular system for targeted photothermal ablation of perivascular nerves is disclosed. A catheter includes a fluid lumen communicating with outlet orifices, and an electromagnetic radiation emitter positioned within a support structure that apposes the array against a vessel wall. A proximal console independently controls irradiation and injection parameters. In use, a nanofluid comprising plasmonic nanoparticles, such as gold nanorods tuned for near-infrared absorption, is injected into or through the vascular wall and subsequently irradiated intraluminally; the nanofluid absorbs energy and converts it to heat to ablate adjacent nerve fibers while reducing non-target tissue heating.

Medical systems, devices and methods for creation of autologous tissue valves within a mammalian body are disclosed. One example of a device for creating a valve flap from a vessel wall includes an elongate tubular structure having a proximal portion and a distal portion and a longitudinal axis; a first lumen having a first exit port located on the distal portion of the elongate tubular structure; a second lumen having a second exit port located on the distal portion of the elongate tubular structure; a recessed distal surface on the distal portion of the elongate tubular structure, wherein the recessed distal surface is located distally to the first exit port; and an open trough on the recessed distal surface extending longitudinally from the first exit port.

The invention discloses a cardiovascular disease assessment method and system based on CT enhanced scanning examination, relates to the technical field of CT enhanced scanning, and discloses the cardiovascular disease assessment method and system based on CT enhanced scanning examination, which obtains original projection data through dynamic CT enhanced scanning, and calculates permeability function data and time delay data; a vascular wall inflammation score and a microcirculation dysfunction score are generated by using a dual-channel deep learning fusion model, so that synchronous quantitative evaluation of vascular wall inflammation activity and microcirculation functions is realized, and the vascular wall inflammation activity state and the microcirculation dysfunction degree can be synchronously quantified; therefore, the accuracy of cardiovascular disease risk assessment is improved.

The present application relates to the application of delta-Viniferin in the preparation of drugs for preventing or treating metabolic cardiovascular diseases. Delta-Viniferin can inhibit the expression level of aging and inflammation related genes / proteins of vascular endothelial cells, reduce endothelial dysfunction, and clarify its anti-hypertensive effect. Delta-Viniferin can inhibit the expression level of vascular smooth muscle cell phenotype conversion related genes / proteins, improve the contraction function of vascular smooth muscle, and significantly alleviate the degradation of elastic fibers of the vascular wall and the rupture of the intima of the aortic wall in vivo, and clarify its effect on preventing and treating aortic dissection. Delta-Viniferin can inhibit the expression level of myocardial fibroblast fibrosis related genes / proteins, and clarify its anti-myocardial fibrosis effect. Delta-Viniferin can promote white adipose tissue browning by targeting the SIRT1-FOXO1 axis, increase energy consumption, and clarify its effect on resisting obesity. In summary, the compound delta-Viniferin has the effect of protecting various metabolic cardiovascular diseases, and can be used to prepare drugs for preventing and treating metabolic cardiovascular diseases.

This invention relates to the field of medical image reconstruction technology, specifically to a method for reconstructing low-dose CT images of patients with coronary artery disease based on image enhancement. The method includes: acquiring multi-angle raw projection data of low-dose CT images from patients with coronary artery disease; performing statistical noise modeling and signal recovery on the projection data to obtain denoised projection data; generating an initial coronary CT image sequence through an iterative reconstruction algorithm; extracting cardiac structures and completing region segmentation to obtain labeled images; performing region-specific differential image enhancement based on the labeled images; enhancing vessel wall details and extracting calcified plaque features; combining edge-preserving noise suppression with post-optimization; and outputting high-quality low-dose CT reconstructed images. This method effectively improves the noise artifact problem caused by low-dose scanning, preserves key anatomical details and lesion features of the coronary arteries and myocardium, and enhances the clinical diagnostic practicality of low-dose CT images for coronary artery disease.

According to an aspect of the present invention, there is provided a method for imaging vasa vasorum density of a vessel in the body such as coronary and carotid arteries and the aorta and thereby assessing the risk of adverse health outcomes for a patient, comprising administering a contrast agent to the patient; performing a contrast-enhanced CT scan to measure Hounsfield distribution and heterogeneity related to vasa vasorum density in and around the vessel wall of a patient; analyzing the data to determine a metric related to the density of the vasa vasorum; and recommending a diagnostic and / or therapeutic next step to the patient to prevent adverse health outcomes based at least in part on the metric related to the vasa vasorum density.

In some examples, a medical system includes processing circuitry configured to determine the periodicity of the flow rate of fluid delivered by the medical system to a balloon for medical ablation. The balloon is configured to inflate to facilitate heat transfer between the vessel wall and the fluid flowing through the balloon. The medical system is configured to vary the flow rate of the fluid delivered to the balloon between an upper and lower limit flow rate within this period. When the medical system delivers fluid at the upper limit flow rate, the lower limit flow rate, and this period, the upper limit flow rate, the lower limit flow rate, and the period maintain tissue at a tissue depth within a narrow temperature range around a target temperature.

Systems and methods of facilitating determination of risk of coronary artery disease (CAD) based at least in part on one or more measurements derived from non-invasive medical image analysis. The methods can include accessing a non-invasive generated medical image, identifying one or more arteries, identifying, regions of plaque within an artery, analyzing the regions of plaque to identify low density non-calcified plaque, non-calcified plaque, or calcified plaque based at least in part on density, determining a distance from identified regions of low density non-calcified plaque to one or more of a lumen wall or vessel wall, determining embeddedness of the regions of low density non-calcified plaque by one or more of non-calcified plaque or calcified plaque, determining a shape of the more regions of low density non-calcified plaque, and generating a display of the analysis to facilitate determination of one or more of a risk of CAD of the subject.

Endovascular valve formation systems with imaging capabilities and associated devices and methods are disclosed herein. In some embodiments, a valve formation and imaging system can include, for example, (i) a valve formation device configured to access a vessel wall and dissect a portion of the vessel wall to form an autologous valve leaflet and (ii) an imaging device configured to image the vessel wall and components of the valve formation device during a valve formation procedure. In some embodiments, the imaging device is integrated into a distal end portion of the valve formation device. In some embodiments, the imaging device is a separate catheter device positionally coupled to the valve formation device and / or components thereof.

Systems and methods can involve wedge dissectors attached to strips in turn attached to medical balloons, for forming serrations within vascular wall tissue for angioplasty as well as drug delivery. Such balloon blowing techniques can reduce the balloon profile, the material costs, and the manufacturing time to build a serrated balloon catheter device. The design and process to build this type of balloon is described herein.

This application provides a method and system for in vivo stent orientation based on the principle of spatial reversal, relating to the field of vascular interventional technology. The method includes: during the advancement of a main stent delivery system carrying an integrated branch stent along an ultra-rigid guidewire towards the aortic arch, acquiring the orientation information of the delivery system and its contact force information with the vessel wall; then comparing the orientation information with a spatial reference path, and determining the entry point into the curved section of the aortic arch based on the comparison results; generating a reversal speed adjustment amount based on the deviation of the delivery system's orientation from the branch vessel opening direction, the vessel curvature, and the contact force information; finally, controlling the delivery system to rotate synchronously during advancement based on this adjustment amount, gradually adjusting the orientation of the branch stent from a preset position to directly facing the opening of the left subclavian artery, while dynamically adjusting the advancement speed according to the contact force information to maintain the contact force within a preset safe range. This application improves the accuracy and operational safety of in vivo stent orientation.

According to the pulse wave analysis method based on ultrasonic imaging, the pulse wave analysis equipment and the ultrasonic imaging system, ultrasonic data stored in a real-time scanning state can be read in a non-real-time scanning state, and the pulse wave analysis equipment is used for analyzing the pulse wave based on the ultrasonic image. Performing pulse wave analysis again according to the read ultrasonic data to obtain and output a pulse wave analysis result after reanalysis; besides, in the function of performing pulse wave analysis again in a non-real-time scanning state to obtain a pulse wave analysis node after reanalysis, one or more links such as redetermination of an interested area, reidentification of a blood vessel wall and reidentification of the early / late period of the heart can be extended; the flexibility of the pulse wave analysis function, the utilization rate of case data and the efficiency of clinical diagnosis can be greatly improved.

This invention provides a graded embolization protection device, belonging to the field of vascular interventional medical device technology. The device includes a delivery guidewire, with multiple protection units fixedly arranged at intervals at the distal end of the guidewire. Each protection unit has a proximal open end and a distal closed end, and each protection unit has a flexible support frame for support at a target location. Multiple open areas are formed on the support frame, and a soft, elastic filter membrane is arranged on the edge of each open area or on the sidewall of the entire support frame to cover the open area. In use, the multiple protection units are axially deployed graded along the target location, with the flexible support frame of each protection unit fully conforming to the inner wall of the blood vessel, and the soft, elastic filter membrane intercepting emboli in the blood flow. This addresses at least the technical problems of existing embolization protection devices, such as poor flexibility due to the high coverage of the rigid support structure, difficulty in adapting to complex vascular morphologies, and poor fit with the vascular wall, leading to embolism escape.

This invention provides a delivery device and system for delivering stents. The delivery device includes a sheath for receiving the stent and a support member slidably disposed within the sheath. The support member includes a pushing portion and a plurality of supporting portions disposed within the pushing portion, wherein the distal ends of at least two supporting portions are not flush with each other, so that the proximal end of the stent can be released from the support member in stages. The delivery device of this invention can effectively prevent the proximal end of the vascular stent from simultaneously springing outwards at the same moment during release, thus avoiding further damage to the surrounding vascular wall.