4320 results about "Thrombus" patented technology

The invention discloses a thrombus excision system. An embolus is extracted through a mechanical embolus extraction device, a blood vessel is dredged, and revascularization of the blood vessel is achieved. A saccule guide catheter is put at the near end of the embolus part when the embolus is extracted, blood flow is temporarily blocked, and thus a fine crushed embolus generated in the embolus extraction process is prevented from being flushed to the far end of the blood vessel; meanwhile, for a relatively large embolus, a part of thrombus can also be sucked by virtue of the saccule guide catheter, and then the residual thrombus can be extracted by virtue of a thrombus exsector. The thrombus exsector, the saccule guide catheter and a delivery microcatheter are arranged on the thrombus excision system disclosed by the invention, wherein the thrombus exsector is used as a main component, an excision spring is arranged, and the release state of the excision spring is a conical spiral state. Compared with the prior art, the thrombus excision system has the advantages that the thrombus exsector is very soft, the minimal through size is 0.014' (0.36mm), the thrombus exsector can easily enter a cerebral vessel, a near-end protection technology is adopted in the operation process, and thrombus suction is combined with mechanical embolus extraction, so that the success rate of the operation is improved, and the complications are reduced.

The invention relates to a device for treating thrombosis of a blood vessel by ultrasound, comprising:-a therapeutic ultrasound transducer (TUT) adapted to generate focused ultrasound waves (OUF) propagating along a transmission axis (AE); -an imaging ultrasound transducer (TUI) for use with the therapeutic transducer; -means (SMDR, FEF) for moving the focal region of the therapeutic ultrasound transducer, for moving the focal region of the therapeutic ultrasound transducer relative to the imaging transducer along the emission axis; a motorized mechanical system (SMM) for translating the transducer at least along a first axis (AD1) parallel to the emission axis and a second axis (AD2) perpendicular to the first axis; -an electronic control system (SEC) for controlling the motorized mechanical system and means for moving the focal region of the treatment transducer.

A method of extracting a thrombus from a thrombus site in a cerebral artery of a patient by advancing a first catheter into an internal carotid artery of the patient; advancing a funnel within the first catheter; moving the funnel and the first catheter with respect to each other to place the funnel outside of the first catheter; expanding the funnel into contact with an inner wall of the internal carotid artery at or proximal to a distal end of a carotid siphon, thereby reducing blood flow past the funnel; applying suction through the funnel; advancing a clot-mobilizer through the first catheter toward the thrombus; engaging thrombus material from the thrombus with the clot-mobilizer; moving the clot-mobilizer and thrombus material proximally at least partially into the funnel; and moving the funnel, the clot-mobilizer and the thrombus material proximally within the vasculature.

The invention relates to the technical field of health status assessment, in particular to a cardiovascular disease layered early warning system, which is characterized in that blood vessel compliance and pulse wave velocity are extracted, arterial dilation capacity is measured, blood vessel elasticity is calculated, blood perfusion distribution is detected, and abnormal vasoconstriction is classified on the basis of a hemodynamic state and a heart electrical activity state; in combination with the thickness of the blood vessel wall and the blood vessel stenosis rate, the plaque deposition condition is analyzed, the arteriosclerosis score is calculated, the thrombosis tendency is detected, the local blood flow blocking degree is quantified, the isolation forest algorithm is adopted, the blood flow dynamic change is calculated, the heart rhythm abnormality is analyzed, the acute vascular occlusion probability is measured, and the sudden heart rhythm abnormality risk is evaluated. And based on a gradient boosting tree algorithm, screening high-risk cases, matching medical intervention measures, setting a risk buffer mechanism, adjusting an individual health management strategy, and optimizing a cardiovascular risk hierarchical early warning system.

A method and system for determining a regional weakening (RW) value in a blood vessel using ultrasonic imaging. A set of images of a portion of a given patient's body collected over time is received. A set of measurements representing the movement of the tissue of the blood vessel is received, and the set of measurements is determined based on the set of images. The movement of the wall and lumen at least partially indicates strain. A blood flow velocity value in the blood vessel is determined based on a Doppler image, and an RW parameter indicating the state of weakening in a region of the blood vessel is determined based on at least the set of measurements, thrombus burden, and blood flow velocity value. A map showing the circumference of the blood vessel including the regional weakening value and the strain value may be displayed.

Disclosed herein are clot treatment systems including integrated / systemized mechanical thrombectomy devices and clot treatment devices, and associated devices and methods. In some embodiments, a method of removing clot material from a blood vessel of patient includes inserting a catheter to proximate the clot material within the blood vessel while radially constraining a clot treatment device and an embolic protection device within the catheter. The method can further include moving the catheter proximally to deploy the clot treatment device at least partially distal to clot material within the blood vessel, and then moving the catheter further proximally to deploy the embolic protection device at least partially proximal to the clot material.

Disclosed herein are clot treatment systems including integrated / systemized mechanical thrombectomy devices and clot treatment devices, and associated devices and methods. In some embodiments, a method of removing clot material from a blood vessel of patient includes inserting a catheter to proximate the clot material within the blood vessel while radially constraining a clot treatment device and an embolic protection device within the catheter. The method can further include moving the catheter proximally to deploy the clot treatment device at least partially distal to clot material within the blood vessel, and then moving the catheter further proximally to deploy the embolic protection device at least partially proximal to the clot material.

Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the thrombectomy system. The system can include a catheter having a distal portion configured to be positioned adjacent to a thrombus in a blood vessel, an electrode disposed at the distal portion of the catheter, and an interventional element configured to be delivered through a lumen of the catheter. The electrode and the interventional element are each configured to be electrically coupled to an extracorporeal power supply.

Systems and methods for removal of thrombus from a blood vessel in a body of a patient are disclosed herein. The method can include: providing a thrombus extraction device including a proximal self-expanding member formed of a unitary fenestrated structure, a distal substantially cylindrical portion formed of a net-like filament mesh structure, and an inner shaft member connected to a distal end of the net-like filament mesh structure; advancing a catheter constraining the thrombus extraction device through a vascular thrombus, deploying the thrombus extraction; retracting the thrombus extraction device to separate a portion of the thrombus from the vessel wall and to capture the portion of the thrombus within the net-like filament mesh structure; and withdrawing the thrombus extraction device from the body to remove thrombus from the patient.

A thrombectomy device including a delivery catheter; a tapered dilator catheter configured to be movably disposed within the delivery catheter; and an expandable aspiration funnel configured to be movably disposed within the delivery catheter in a retracted position and at least partially outside the delivery catheter in an extended position, the funnel comprising a non-permeable covering, a diameter of a distal end of the funnel being greater in the extended position than in the retracted position, the funnel being configured to adapt its shape and length to a surrounding blood vessel such that the funnel lengthens as it narrows to retain a thrombus within the funnel. The invention also includes methods of using the device.

The invention discloses an epoxy group modified zwitterionic polymer / heparin composite coating and a preparation method thereof. The preparation method comprises the following steps: firstly, constructing an amino-containing adhesion layer on the surface of a substrate by adopting a dip-coating method; then, the substrate is soaked in a mixed solution of the zwitterionic polymer and the heparin, and grafting of the zwitterionic polymer and the heparin on the surface of the medical material is completed through incubation. The coating provided by the invention has excellent hydrophilicity, can form a hydration layer, provides a physical barrier, and remarkably prevents adhesion and colonization of microorganisms. The inhibition rate of the coating on escherichia coli and staphylococcus aureus exceeds 99%, protein adhesion is remarkably reduced in an anti-protein adhesion experiment, and the coating is simple in strategy design, has a potential application prospect in the aspect of preventing blood contact catheter related infection and thrombosis, and has a wide application prospect. The complication occurrence rate and the medical care cost can be reduced.

The invention provides conotoxin-derived anticoagulant polypeptide Cb-13 and application thereof, and belongs to the technical field of biological medicine. The invention provides an anticoagulant polypeptide Cb-13. The amino acid sequence of the anticoagulant polypeptide Cb-13 comprises SEQ ID No.1. The invention also provides a coding gene of the anticoagulant polypeptide Cb-13, and provides that the anticoagulant polypeptide Cb-13 does not have hemolytic activity and does not have cytotoxicity when the concentration is 400 [mu] M or below. The anticoagulant polypeptide Cb-13 disclosed by the invention has a prolonging effect on plasma recalcification and coagulation time, has an anticoagulant effect, has small influence on bleeding, and also has an obvious promoting effect on plasmin and uPa. Meanwhile, it is also proved that the anticoagulant polypeptide Cb-13 can inhibit thrombus formation, that is, the anticoagulant polypeptide Cb-13 has in-vivo and in-vitro fibrinolytic effect and anticoagulant effect, has small bleeding risk, and can be used as an antithrombotic or thrombolytic drug.

The thrombus aspiration catheter with the high stability comprises a hollow catheter body, one end of the catheter body is provided with a negative pressure end connected to an external negative pressure component and a sealing end connected with a hollow guide wire tube, and the guide wire tube penetrates through the sealing end and extends to an aspiration end arranged at the other end of the catheter body. A negative pressure hole is formed in the side, close to the negative pressure end, of the guide wire tube, the end, close to the suction end, of the guide wire tube is connected with a thrombus breaking component, an adsorption part is arranged at the joint of the thrombus breaking component and the guide wire tube, a plurality of adsorption holes are formed in the circumferential direction of the adsorption part, and the negative pressure hole is connected with the adsorption holes through a connecting channel arranged in an inner cavity of the guide wire tube. Therefore, thrombus broken by the thrombus breaking component can be adsorbed conveniently. After the thrombus breaking component rotates, a large thrombus can be broken into a small thrombus, the large thrombus is prevented from blocking a catheter and a blood vessel, the thrombus suction effect is improved, the thrombus suction stability of the catheter is improved, and the suction operation efficiency is improved.

Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions.

The invention discloses an intelligent training method for preventing lower limb thrombus and a related device, and the method comprises the steps: inputting the physiological parameters of a patient, the initial exercise ability evaluation information and the personalized rehabilitation target information into a DQN multi-mode fusion model, and generating an ankle pump exercise training scheme meeting the rehabilitation demands of the patient; monitoring ankle pump motion execution information of the patient in real time through wearable equipment; according to the ankle pump motion training scheme and the ankle pump motion execution information of the patient, a lower limb thrombus training effect evaluation result of the patient is calculated, and the lower limb thrombus training effect evaluation result comprises the blood circulation improvement degree, the joint motion range and the gait characteristics; according to a lower limb thrombus training effect evaluation result of the patient, predicting lower limb thrombus potential recovery disorder and a falling risk level of the patient, and starting a grading alarm program according to the potential recovery disorder and the falling risk level. The training effect is comprehensively evaluated through the multi-modal data fusion training method, and the lower limb thrombus rehabilitation efficiency is improved.

Systems and methods include positioning of a catheter lumen in a first position with respect to a thrombus, the catheter lumen defined by a catheter, initiating of evacuation of a tubing lumen, where the tubing lumen is not in fluid communication with the catheter lumen, determination that a pressure within the tubing lumen is equal to or less than a target aspiration pressure, and, in response to the determination that the pressure within the tubing lumen is equal to or less than a target aspiration pressure, automatic establishment of fluid communication between the tubing lumen and the catheter lumen.

A method for removing a clot from a vessel involves the use of a device that can have dual layers where an inner expandable member runs within an outer expandable member. The inner expandable member can be divided into one or more sections, with a proximal section having a clot pinching structure configured to pinch the clot between the pinching structure and an outer catheter. A distal flow channel section of the inner member can be configured to create a flow channel through the clot to restore blood to the downstream vasculature. The struts of the outer expandable member can form closed cells that are not fully circumferential in a proximal portion to allow a clot to pass inside and engage the pinching structure, and fully circumferential in a distal portion to scaffold the vessel for dislodging the clot. A protective element at the distal end of the device can prevent the escape of clot fragments.

The thrombus catcher comprises a thrombus catching section, a wall attaching section and a closing section, the thrombus catching section is of a conical hollow structure with the near end open and the far end diameter gradually reduced, the wall attaching section is woven along the near end of the thrombus catching section and is of a mesh enclosure structure, and the closing section is woven along the near end of the wall attaching section and is arranged in a stranded mode. The thrombus capturing section, the wall attaching section and the closing-in section are integrally formed and woven and are coaxially arranged, the thrombus capturing device is integrally woven, the overall flexibility is good, the thrombus capturing device is not prone to being bent and folded in a blood vessel, thrombus capturing is prevented from being affected, the wall attaching section of the thrombus capturing device can be tightly attached to the blood vessel wall after being released, thrombus is prevented from escaping, and the thrombus capturing effect is good. The woven fan blades wrap the thrombus to prevent thrombus leakage during recovery, the coaxial design enables the thrombus to be not prone to displacement, and the thrombus capturing capacity in the operation is greatly enhanced.

Methods and apparatuses for using intravascular ultrasound in combination with aspiration to remove intraluminal obstructive material (e.g., thrombus / clot material). These methods and apparatuses may allow the removal of intraluminal obstructive material embodiments using an integrated intravascular ultrasound transducer arrays that is arranged to enhance imaging of both target clot material and a zone of aspiration based on the position and orientation of the aspiration orifice.

Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism, deep vein thrombosis, cerebrovascular embolism, and other vascular occlusions. The capture system can include a tubular body comprising a first end, a second end, and an axial length therebetween, the first end having an opening and a capture guide. The capture system can include one or more tensioners coupled to the capture guide. The tubular body has a first configuration in which the first end and the capture guide are expanded while the second end and a majority of the tubular body remains compressed. The tubular body is transformable to a second configuration by application of tension by the tensioners. The catheter can remove a large volume of clot.

The invention belongs to the technical field of medical instruments, and particularly relates to a dense net support. The dense net support comprises a front fixing section, a blocking section and a rear fixing section, and the blocking section is located between the front fixing section and the rear fixing section. The plugging section is connected with the front fixing section through a front connecting piece, and the plugging section is connected with the rear fixing section through a rear connecting piece; the plugging section is used for plugging an aneurysm position of a blood vessel, the plugging section sequentially comprises an inner layer part, a middle layer part and an outer layer part from inside to outside, the inner layer part adopts an inner layer metal stent, and the outer layer part adopts an outer layer metal stent. The dense net stent can adjust hemodynamics more accurately, and it is ensured that the blood flow of healthy blood vessels is not affected while the aneurysm is closed; the sealing effect of the aneurysm is ensured, and thrombosis is well promoted, so that blocking and healing of the aneurysm are promoted; and the endothelialization process of the stent is facilitated, so that the success rate of fusing the stent into the blood vessel is improved, the effect of completely sealing the aneurysm opening is achieved, and the recurrence risk is reduced.

An implantable pump system is provided, suitable for use as a left ventricular assist device (LVAD) system, having an implantable pump, a battery, a controller, and a programmer. The implantable pump includes a flexible membrane coupled to an actuator assembly via a skirt that extends toward the inlet of the pump and curves to guide blood toward the outlet. The actuator assembly is magnetically engageable with electromagnetic coils, so that when the electromagnetic coils are energized, the actuator assembly causes wavelike undulations to propagate along the flexible membrane to propel blood from the inlet, across the skirt, and through the outlet of the implantable pump. The controller may be programmed by a programmer to operate at frequencies and duty cycles that mimic physiologic flow rates and pulsatility while operating in an efficient manner that avoids thrombus formation, hemolysis and / or platelet activation.

The invention discloses a venous thrombosis risk assessment method and system based on a large language model and deep learning, and the method and system can comprehensively capture the clinical information of a patient through the comprehensive utilization of multi-dimensional and multi-modal clinical diagnosis and treatment data, and improve the accuracy of risk assessment. An automatic feature extraction and selection technology is realized by applying a large language model, manual intervention is reduced, and the comprehensiveness and accuracy of feature extraction are improved. The introduction of the deep learning model enhances the prediction performance of the model, supports real-time data processing and risk prediction, and realizes the automation and real-time performance of risk assessment. Besides, the model framework supports continuous learning and updating, can adapt to new clinical data and research progress, and keeps advancement and effectiveness of the model, thereby providing high-quality hospitalized patient VTE risk assessment services.

Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions. The capture system can include a tubular body comprising a first end, a second end, and an axial length therebetween, the first end having an opening and a capture guide. The capture system can include one or more tensioners coupled to the capture guide. The tubular body has a first configuration in which the first end and the capture guide are expanded while the second end and a majority of the tubular body remains compressed. The tubular body is transformable to a second configuration by application of tension by the tensioners. The catheter can remove a large volume of clot. In some embodiments, the body of the catheter or the funnel tip is expandable. The catheter can include a dilator and a peel-away cover.

The invention discloses a catheter with a state-changeable end and a using method, and relates to the technical field of interventional medical instruments. And a deformable body and an adjusting assembly. The diameter of the deformable body is adjusted through the adjusting assembly, so that the diameter of at least part of the deformable body is gradually reduced from the near-end direction to the far-end direction, in the advancing process of the catheter, the deformable body is kept to be small in size, blood vessel wall damage caused by the windowsill effect is prevented, and operation of an operator is convenient and fast; the intervention difficulty is reduced; after the deformable body is in place, the diameter of at least part of the deformable body can be gradually increased from the near-end direction to the far-end direction through the adjusting assembly, the larger suction area is obtained in the suction process due to the increase of the size of the deformable body, the suction efficiency and the thrombus removing effect are improved, the operation time is shortened, and the operation risk is reduced.

Described herein are systems, devices, and methods for methods for autologous blood transfusion. For example, an apparatus may comprise a fluid conduit configured to receive a volume of fluid from a patient and a container fluidically coupled to the fluid conduit. The container may define a reservoir configured to receive the volume of fluid from the fluid conduit. The apparatus may include a vacuum conduit couplable to a vacuum source, a vent configured to vent air into the reservoir, and at least one valve configured to couple the reservoir to the vacuum conduit to generate negative pressure within the reservoir such that the volume of fluid is drawn into the reservoir, and decouple the reservoir from the vacuum conduit while coupling the reservoir to the vent such that air is vented into the reservoir at an average rate that prevents turbulent movement of the volume of fluid within the reservoir.

The invention provides an anticoagulant coating for medical instruments, which can be used in the field of regenerative medical instruments. The prepared anticoagulant coating has short-term and long-term anticoagulant performance, and in addition, the thrombin responsive nanoparticles wrapped in the hydrogel coating can selectively release a factor Xa (FXa) inhibitor apixaban according to needs, so that thrombosis is inhibited in the middle stage of implantation. In-vitro and in-vivo experimental evidences show that after the material is implanted for a long time, an organized endodermis can be seen on the surface of the material, and the material has a special antithrombotic characteristic. The dynamic adjusting system has a multi-layer protection mechanism, and a new thought can be provided for designing the surface of a contact blood material adapting to environmental conditions.

A thrombus engagement tool having a flexible shaft, a clot engagement tip, and a handle. The engagement tip may include one or more radially outwardly extending structures such as a helical thread. The helical thread can be advanced through a catheter to engage a clot. The handle may be configured to be rotated by hand. When the handle is rotated, the helical thread of the engagement tip can rotate in the same direction thereby allowing the helical threat to engage the clot. The helical thread can wrap around the flexible shaft at least about one, two, or four or more full revolutions, but in some cases no more than about ten or no more than about six revolutions.