83424results about How to "Easy to move" patented technology

The present invention includes a surgical stapler having a curved end-effector which is configured to deploy staples in at least one curved staple line. The surgical stapler can include a staple cartridge configured to removably store staples therein, an anvil configured to deform the staples, and a cutting member having a cutting surface. The staple cartridge and / or anvil can include a curved slot configured for receiving and guiding the cutting member wherein at least a portion of the cutting member can be defined by a curvature that substantially matches the curvature of the slot. In these embodiments, the curved cutting member can be easily moved within the curved slot thereby reducing the possibility that the cutting member will become stuck within the slot.

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

A surgical sealing device (405), suitable for use during a surgical procedure such as a laparoscopic procedure or a hand-assisted laparoscopic procedure, comprises a first sealing member (5) and a second sealing member (6). A thin slit is defined between the sealing members (5, 6). In a closed configuration, the first sealing member (5) overlaps the distal end opening of a passageway (2) through the second sealing member (6) to prevent leakage of insufflation gases out of an abdomen (4). In an open configuration, the first sealing member (5) is retracted to reveal the distal end opening of the passageway (2) and thus facilitate passage of an object, such as a surgeon's hand or forearm (3), into the abdomen (4). The device (405) comprises a planar support element (406) fixedly attached to the proximal exterior surface (408) of the first sealing member (5). The first sealing member (5) is fixedly attached to the second sealing member (6) at an attached region (409), with a detached region (407) remaining detached from the second sealing member (6). The support element (406) acts as a stiffening element to increase the stiffness of the detached region (407) of the first sealing member (5) to minimise the deformation of the detached region (407) of the first sealing member (5) when the surgeon's hand / forearm (3) is pushed through the passageway (2). It is thus easier for the surgeon to retract the first sealing member (5) laterally to reveal the distal end opening of the passageway (2) by pushing the hand / forearm (3) through the passageway (2) and easier for the surgeon to pass the hand / forearm (3) through the device (405) and gain access to the abdomen (4).

A surgical stapler has a handle assembly including a stationary handle and a trigger. The stapler also has a drive assembly with a body having a working end and a cam member supported on the working end. The cam member is positioned to translate relative to the anvil to maintain the anvil in the closed position during firing of the stapler. The trigger is operatively connected to a power cell. The power cell is operably connected to a motor of the drive assembly. The manipulation of the trigger actuates the power cell such that the power cell powers the drive assembly to effect translation of the cam member relative to the anvil. The stapler also has a channel for supporting the staple cartridge and the motor of the drive assembly controls the actuation sled supported within the cartridge. The actuation sled urges the plurality of staples from the cartridge when the anvil is in the closed position and in cooperative alignment with the staple cartridge.

The present invention provides modular intraluminal tubular prostheses, particularly stents and stent-grafts, for the treatment of disease conditions, particularly aneurysms. Modular sections of the prostheses, or "prosthetic modules," may be selectively combined to form a composite prosthesis having characteristics which are tailored to the specific requirements of the patient. Each prosthetic module preferably includes one or more standard interface ends for engaging another module, the module / module interface typically comprising ends which overlap and / or lock within a predetermined axial range. Advantageously, the axial length, cross-section, perimeter, resilient expansive force, axial flexibility, liner permeability, liner extensibility, radial conformability, liner / tubal wall sealing and anchoring, and other prosthetic characteristics may be varied along the axis of the composite prosthesis, and also along the axis of each prosthetic module. The modules are preferably individually introduced into a lumen system of a patient body so that the composite prosthesis is assembled in situ. Ideally, selection of appropriate prosthetic modules and the flexibility of the interface overlap range provides a custom fit intraluminal prosthesis which provides a therapy tailored to the individual patient's needs.

Modified DNA polymerases have an affinity for DNA such that the polymerase has an ability to incorporate one or more nucleotides into a plurality of separate DNA templates in each reaction cycle. The polymerases are capable of forming an increased number of productive polymerase-DNA complexes in each reaction cycle. The modified polymerases may be used in a number of DNA sequencing applications, especially in the context of clustered arrays.

A multimedia bookmark (VMark) bulletin board service (BBS) system comprises: a web host comprising storage for messages, a web server, and a VMark BBS server; a media host comprising storage for audiovisual (AV) files, and a streaming server; a client comprising storage for VMark, a web browser, a media player and a VMark client; and a VMark server located at the media host or at the client; a communication network connecting the web host, the media host and the client. A method of performing a multimedia bookmark bulletin board service (BBS) comprises: creating a message including a multimedia bookmark for an AV file; and posting the message into the multimedia bookmark BBS. A method of sending multimedia bookmark (VMark) between clients comprises: at a first client, making a VMark indicative of a bookmarked position in an AV program; sending the VMark from the first client to a second client; and playing the program at the second client from the bookmarked position. A system for sharing multimedia content comprises: a multimedia bookmark bulletin board system (BBS); and means for posting a multimedia bookmark to the BBS.

An aerosol generator includes a flow passage having an inlet and an outlet, a heater arranged relative to the flow passage for heating the flow passage, a source of material to be volatilized in communication with the inlet of the flow passage, a valve to open and close communication between the source of material and the inlet of the flow passage, and a pressurization arrangement for causing material in the source of material to be introduced into the flow passage when the valve is in an open position. The aerosol generator further includes a source of power for operating the heater and the valve, and a control device for controlling supply of power from the source of power to the heater and the valve. A metering device in an inhaler includes a pressurized source of medicated fluid and a metering chamber configured to deliver a predetermined volume of fluid to a heated flow passage in the inhaler. The metering chamber can be part of a rotary valve having a bore and a displacement member moveable within the bore from a first position where the fluid is loaded into the bore to a second position where the predetermined volume is ejected out of the bore. Another metering chamber has an elastic portion of a delivery passage in fluid communication with the pressurized source of liquid and the elastic portion of the delivery passage is deformed to eject the predetermined volume.

A bone fixation assembly including a coupling element having an inner surface defining a first bore coaxial with a first longitudinal axis, and a second bore coaxial with a second longitudinal axis, whereby the second longitudinal axis intersects the first longitudinal axis. The coupling element has a seat adjacent the lower end of the coupling element, the seat being defined by the inner surface of the coupling element. The assembly includes an anchoring element assembled with the coupling element, the anchoring element having a first end for insertion into bone and a head spaced from the first end, the head being in contact with the seat of the coupling element. The assembly provides sufficient angulation between adjacent anchoring elements securing a common orthopedic rod, and is particularly useful for assemblies mounted in spines having abnormal curvatures and in the cervicothoracic region of the spine.

Screen having a touch-sensitive user interface (8) for command input via local touching of the user interface (8) and generation of a command signal where the extent of touch is sufficient, comprising electrically actuatable means (5) assigned to the user interface (8) to generate a signal that is haptically perceptible to the user in the position touched on the user interface (8), depending on a command signal being generated.

Spinal stabilization devices, systems and methods are provided that include at least one pedicle screw and at least one mechanism that supports three degrees of rotational freedom relative to the pedicle screw. The mechanism may include a universal joint mechanism or a ball and socket mechanism. In the case of the ball and socket mechanism, at least one spherical element is mounted with respect to the at least one pedicle screw and a socket member cooperates with the spherical element. The spherical element and the socket member cooperate to define a dynamic junction that allows the socket member to move relative to the ball element while remaining engaged therewith. The dynamic junction is advantageously incorporated into a spinal stabilization system that includes additional pedicle screw(s), spherical element(s) and socket member(s). The spinal stabilization system may incorporate dynamic stabilizing member(s) to so as to provide clinically efficacious results.

An ultrasonic surgical clamp coagulator apparatus is configured to effect cutting, coagulation, and clamping of tissue by cooperation of a clamping mechanism of the apparatus with an associated ultrasonic end-effector. The handle of the apparatus is configured to permit hand activation for cutting, coagulation, and clamping of tissue during surgical procedures. In order to promote convenient and efficient use of the apparatus, the fingertip controls are provided directly into the disposal shears handle in a position that allows surgeons to activate the device without repositioning their hand. The two buttons provide independent control of the two power levels available from the generator, matching the two foot pedal configuration of the prior art.

A physiological sensor device for attachment to a mammalian subject including first and second regions of sensors attachable to a subject in use, which first and second regions of sensors are separated by a flexible web adapted to enable variable separation of the first and second sensor regions from one another in use. The physiological sensor device is manufactured by forming a strip of electrically conductive material on a flexible electrically non-conductive substrate and cutting a slot through both the flexible substrate and conductive strip to define a pair of adjacent edges of conductive material separated by a non-conductive gap thereby also to define adjacent electrode sensors each having one of the pair of adjacent edges formed in the strip of conductive material. The physiological sensor device is attached to the subject for measurement of numerous physiological parameters for a period of time, such as 24 hours, and is then thrown away.

A method for forming an insulation film on a semiconductor substrate by plasma reaction includes: introducing into a reaction chamber a source gas of a silicon-containing hydrocarbon compound comprising in its molecule at least one Si—O bond and at least one bond selected from the group consisting of a Si—Si bond, Si—N bond, and Si—H bond; introducing into the reaction chamber an additive gas constituted by C, H, and optionally O; controlling a susceptor at a temperature of −50° C. to 50° C.; forming by plasma reaction an insulation film constituted by Si, O, H, and optionally N on an irregular surface of a substrate at a deposition rate of 100 nm / min or less; and heat-treating the substrate with the insulation film, thereby increasing a density of the insulation film to more than 2.1 g / cm3 as a result of the heat treatment.

A surgical implant is provided that includes first and second abutment surfaces between which are positioned a force imparting mechanism. A sheath is positioned between the first and second abutment surfaces, and surrounds the force imparting mechanism. The sheath is fabricated from a material that accommodates relative movement of the abutment members, while exhibiting substantially inert behavior relative to surrounding anatomical structures. The sheath is generally fabricated from expanded polytetrafluoroethylene, ultra-high molecular weight polyethylene, a copolymer of polycarbonate and a urethane, or a blend of a polycarbonate and a urethane. The force imparting member may include one or more springs, e.g., a pair of nested springs. The surgical implant may be a dynamic spine stabilizing member that is advantageously incorporated into a spine stabilization system to offer clinically efficacious results.

The invention is directed a delivery system for implantation a self-expanding medical device in a body which includes a control handle and a catheter portion. The catheter portion includes an outer restraining member which covers the collapsed, medical device, an inner catheter member having a distal end including a region upon which the medical device is mounted, and an outer sheath which is removably attached to the control handle. The outer sheath creates a conduit for the catheter portion to prevent the inner catheter member from moving axially when the outer restraining member is retracted. The control handle has a rotatable thumbwheel to actuate a retraction mechanism attached to the proximal end of the outer restraining member which moves the restraining member in a proximal direction to deploy the medical device.

The invention, in various embodiments, is directed to a solid-state flow generator and related systems, methods and applications.

One embodiment of the present invention provides a gas-delivery system for delivering reaction gas to a reactor chamber. The gas-delivery system includes a main gas-inlet port for receiving reaction gases and a gas-delivery plate that includes a plurality of gas channels. A gas channel includes a plurality of gas holes for allowing the reaction gases to enter the reactor chamber from the gas channel. The gas-delivery system further includes a plurality of sub-gas lines coupling together the main gas-inlet port and the gas-delivery plate, and a respective sub-gas line is configured to deliver a portion of the received reaction gases to a corresponding gas channel.

Microneedle devices and methods of manufacturing the microneedle devices. The microneedle devices include microneedles protruding from a substrate, with the microneedles piercing a cover placed over the substrate surface from which the microneedles protrude. The cover and the microneedle substrate together define a capillary volume in fluid communication with the base of each microneedle. One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and / or extract blood or tissue. Manufacturing methods may include simultaneous application of pressure and ultrasonic energy when piercing the cover with the microneedles.

The invention is directed to a delivery system for implantation a self-expanding medical device in a body which includes a control handle and a catheter portion. The catheter portion includes an outer restraining member which covers the collapsed, medical device, an inner catheter member having a distal end including a region upon which the medical device is mounted, and an outer sheath which is removably attached to the control handle. The outer sheath creates a conduit for the catheter portion to prevent the inner catheter member from moving axially when the outer restraining member is retracted. The control handle has a rotatable thumbwheel to actuate a retraction mechanism attached to the proximal end of the outer restraining member which moves the restraining member in a proximal direction to deploy the medical device.