365results about How to "Improve clinical outcomes" patented technology

Data from a plurality of sensors representing a patient's condition, including measurement signals and also secondary parameters derived from the measurement signals, are displayed in a simple way by calculating a novelty index constituting a one-dimensional visualization space. The novelty index is based on the distance of the current data point in a multi-dimensional measurement space, whose coordinates are defined by the values of the measurement signals and secondary parameters, from a predefined normal point. This may be achieved by using a suitably trained artificial neural network to sum the distance between the current data point in the measurement space and a plurality of prototype points representing normality.

A cutting tool to be utilized in the resection or removal of bone tissue from patients includes a handle that tensions a wire or cable-like cutting member with a small diameter between at least two features on the handle to present a thin cutting profile. The design of the cutting tool includes features that protect against soft tissue damage and minimize the incision size necessary to utilize the tool. Some embodiments feature details of the cutting tool that interface with a surgical cutting guide system. Other embodiments describe a cutting tool with a selectively changeable length of the cutting profile of the wire cutting member. In one embodiment, the wire cutting member of the cutting tool is energized by mechanical energy in the form of a unidirectional rotation of the cutting member, a mechanical vibration of the cutting member, or an oscillating movement of the wire cutting member.

The present invention provides systems and methods for the evaluation of the urethra and periurethral tissues using an MRI coil adapted for insertion into the male, female or pediatric urethra. The MRI coil may be in electrical communication with an interface circuit made up of a tuning-matching circuit, a decoupling circuit and a balun circuit. The interface circuit may also be in electrical communication with a MRI machine. In certain practices, the present invention provides methods for the diagnosis and treatment of conditions involving the urethra and periurethral tissues, including disorders of the female pelvic floor, conditions of the prostate and anomalies of the pediatric pelvis.

Soft tissue implants (e.g., breast, pectoral, chin, facial, lip, and nasal implants) are used in combination with an anti-scarring agent in order to inhibit scarring that may otherwise occur when the implant is placed within an animal.

Methods and systems for delivery of digital data in connection with medical treatment and patient care include detecting a current medical condition of a patient receiving medical treatment and delivering electronic informational data to the patient over a network. The informational data can be selected for delivery based on the current medical condition of the patient. The informational data can includes a plurality of informational data content options, and the patient can choose one or more of the informational data content options for delivery to the patient over the network. The chosen content can be displayed to the patient on a digital data display device, such as a touch screen monitor.

Implants are associated with a combination of paclitaxel or derivatives and dipyridamole or derivatives in order to inhibit fibrosis that may otherwise occur when the implant is placed within an animal. Exemplary implants include intravascular implants (e.g., coronary and peripheral vascular stents, catheters, balloons), non-vascular stents, pumps and sensors, vascular grafts, perivascular devices, implants for hemodialysis access, vena cava filters, implants for providing an anastomotic connection, electrical devices, intraocular implants, and soft tissue implants and fillers.

A sampling hub directs a medical device towards a target area. The hub may have some of: a hub body; a lumen passing between openings at the front end and the rear end, the lumen allowing for passage of an elongate element through the entire lumen; the bottom of the hub body may be flat; the top of hub body preferably is sloped downwardly; the lumen is preferably sloped downwardly to enable guidance of the elongate body towards the target area; and an area surrounding the opening of the lumen at the rear end configured to receive a support for the elongate element, the support for the elongate element having a diameter in the support larger than a diameter of the elongate element.

Disclosed is a compound represented by the Structural Formula (I):

• • Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both >C═Z groups to which it is bonded, is a substituted or unsubstituted aromatic group. Preferably, Y is a covalent bond or —C(R₇R₈)—.
  • R₁ and R₂ are independently an aryl group or a substituted aryl group, R₃ and R₄ are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group.
  • R₅-R₆ are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group.
  • R₇ and R₈ are each independently —H, an aliphatic or substituted aliphatic group, or R₇ is —H and R₈ is a substituted or unsubstituted aryl group, or, R₇ and R₈, taken together, are a C2-C6 substituted or unsubstituted alkylene group.
  • Z is ═O or ═S.

Also disclosed are pharmaceutical compositions comprising the compound of the present invention and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a subject with cancer by administering to the subject a compound of Structural Formula (I) in combination with taxol or an analog of taxol.

A method of inserting and positioning an intervertebral spacer is provided. The spacer includes a longitudinal axis, an on-axis interface coincident with or parallel to the longitudinal axis, and an off-axis interface angled to the longitudinal axis. The spacer's front end may be curved. The method may include inserting the spacer into the disc space utilizing a tool to engage an on-axis interface and then to engage one or more of the off-axis interfaces, which may be used for further modification of the spacer. The tool is moved substantially along a single insertion direction, which may be substantially parallel to a posterior-anterior axis of the disc space. The method may result in the longitudinal axis of the spacer being perpendicular to the insertion direction, or substantially parallel to a medial-lateral axis of the disc space. The spacer may also be positioned in an anterior aspect of the disc space.

The invention is a novel adaptive CT-compatible brachytherapy applicator with remotely-controlled radial and longitudinal motion radioactive source lumen shields that can be manipulated by the radiation oncologist to optimize the dose distribution to the target and normal tissue structures for brachytherapy procedures.

The present invention provides for cellular compositions which facilitate engraftment of hematopoietic stem cells from a syngeneic, allogeneic or xenogeneic donor. The cellular compositions of the invention facilitate engraftment while minimizing the risk of graft versus host disease in the graft recipient. According to a preferred embodiment of the invention, a cell composition is provided, which cell composition comprises hematopoietic stem cells, such as CD34⁺ cells and/or facilitating cells, in combination with αβ TCR⁺ T cells. The invention also relates to methods of using the cellular compositions of the invention to induce donor specific tolerance in a recipient, thus allowing the transplantation of donor organs, cells and tissues. Also disclosed are methods of treating leukemia and cancer as well as infectious diseases caused by viruses.