2519 results about "Mortality rate" patented technology

Present invention is a system of blood glucose monitoring and intensive insulin therapy in a ICU for strict maintenance of normoglycemia which reduces intensive care and hospital mortality and morbidity of critically ill adult patients. The findings of present study also reveal factors determining insulin doses needed to maintain normoglycemia as well as the impact of insulin dose versus blood glucose level on the observed outcome benefits have been established. The invention provides a control system that adapts the flow of the insulin infusion based on insulin requirement calculated by blood glucose levels and clinical parameters such as history of diabetes, Body Mass Index, blood glucose level on admission, reason of ICU admission, time in the ICU, type and severity of illness, caloric intake, obesity, drugs affecting insulin sensitivity). This automated insulin monitoring systems significantly reduces the workload and human resource management problems for intensive insulin therapy in patients in the ICU.

Molecules are provided for inducing or facilitating exon skipping in forming spliced mRNA products from pre-mRNA molecules in cells. The molecules may be provided directly as oligonucleotides or expression products of vectors that are administered to a subject. High rates of skipping can be achieved. High rates of skipping reduce the severity of a disease like Duchene Muscular Dystrophy so that the disease is more like Becker Muscular Dystrophy. This is a severe reduction in symptom severity and mortality.

Present invention is a system of blood glucose monitoring and intensive insulin therapy in a ICU for strict maintenance of normoglycemia which reduces intensive care and hospital mortality and morbidity of critically ill adult patients. The findings of present study also reveal factors determining insulin doses needed to maintain normoglycemia as well as the impact of insulin dose versus blood glucose level on the observed outcome benefits have been established. The invention provides a control system that adapts the flow of the insulin infusion based on insulin requirement calculated by blood glucose levels and clinical parameters such as history of diabetes, Body Mass Index, blood glucose level on admission, reason of ICU admission, time in the ICU, type and severity of illness, caloric intake, obesity, drugs affecting insulin sensitivity). This automated insulin monitoring systems significantly reduces the workload and human resource management problems for intensive insulin therapy in patients in the ICU.

Molecules are provided for inducing or facilitating exon skipping in forming spliced mRNA products from pre-mRNA molecules in cells. The molecules may be provided directly as oligonucleotides or expression products of vectors that are administered to a subject. High rates of skipping can be achieved. High rates of skipping reduce the severity of a disease like Duchene Muscular Dystrophy so that the disease is more like Becker Muscular Dystrophy. This is a severe reduction in symptom severity and mortality.

The present invention relates to novel muteins of human fibroblast growth factor 21 with improved pharmaceutical properties. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, metabolic syndrome, and in reducing the mortality and morbidity of critically ill patients.

The invention discloses an ecological scale breeding method of green shell egg laying hens. The method mainly includes the following steps: (1) selecting breeding hens; (2) stocking in a rotational grazing mode in woodland and meadow; (3) selecting hatching eggs; (4) incubating the hatching eggs with an incubator; (5) managing broods of the green shell egg laying hens; (6) managing feeding of the green shell egg laying hens; and (7) preventing epidemic diseases of the green shell egg laying hens. The method is strong in systematicness, changes traditional breeding technology of the green shell egg laying hens, combines with effective breeding measures, improves quality of the breeding hens and the hatching eggs and production capacity of the green shell egg laying hens, increases egg weight and egg yield, and lowers morbidity and mortality rates of the green shell egg laying hens.

A method for treating or preventing spontaneous preterm birth in pregnant women and improving neonatal morbidity and mortality. The method includes administering to a pregnant woman in need thereof an effective amount of progesterone sufficient to prolong gestation by minimizing the shortening or effacing of her cervix. Treatment and prophylaxis with progesterone in pregnant women having symptoms of short cervix has been clinically shown to increase neonatal health.

The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to monitor cardiorenal syndrome using assays that detect NGAL, preferably together with assays that detect natriuretic peptides such as BNP. Such methods and compositions can provide early indications of a deterioration in cardiorenal syndrome status, including prognosis regarding mortality and worsening renal function.

Biomarkers for sepsis and resulting mortality can be detected by assaying blood samples. Changes in the concentration of the biomarkers can be used to indicate sepsis, risk of sepsis, progression of sepsis, remission from sepsis, and risk of mortality. Changes can be evaluated relative to data sets, natural or synthetic or semisynthetic control samples, or patient samples collected at different time points. Some biomarkers' concentrations are elevated during disease and some are depressed. These are termed informative biomarkers. Some biomarkers are diagnostic in combination with others. Individual biomarkers may be weighted when used in combinations. Biomarkers can be assessed in individual, isolated or assays, in parallel assays, or in single-pot assays.

Systems and methods for compiling and presenting physician quality information to consumers are provided. The physician quality information system aggregates data from data sources such as claims data, patient satisfaction data, and public discharge data and computes metrics based on definitions. These metrics can be things such as mortality rate, patient wait time after the scheduled appointment, and whether a physician performed a certain test when a specified set of symptoms were present. The consumer is presented with the physician quality information system through a website. The consumer can enter his or her preferences regarding the physician search into the website and these preferences are used to customize the report that is generated from the information that is computed and complied by the physician quality information system.

The invention discloses a pregnant sow feeding mode and belongs to the technical field of sow breeding. Aiming at physiological characteristics and nutritional requirements of sows during gestation period, the physiological stage of pregnant sows is further subdivided, the nutritional requirements of the pregnant sows at each stage per day are specified, and the body conditions, feeding environments and the like of different pregnant sows are combined. Meanwhile, aiming at the physiological characteristics and feeding modes of the pregnant sows at each stage, pregnancy beginning feed, pregnancy first-half-period feed, pregnancy second trimester feed, pregnancy latter half feed and perinatal feed are scientifically compounded. A reasonable, detailed and scientific feeding mode is formulated, the motion quantity of the pregnant sows can be effectively improved, the nutrient substances are accurately and timely supplied, the functions of the digestion and absorption system and immune system of the pregnant sows are promoted and improved, the number of living piglets is obviously increased, the embryo mortality is reduced, and the birth weight and uniformity of piglets are improved.

Devices and methods are provided for percutaneously treating atherosclerotic plaques within blood vessels. Atherosclerotic plaques cause significant morbidity and mortality by narrowing the arteries, which adversely affects blood flow, and by acting as a source for thrombi and emboli thus causing acute organ ischemia. Current treatments include open surgery with its inherent drawbacks, and stenting, which is less invasive but leaves the plaque material in the artery, which promotes restenosis. The present invention combines the advantages of both approaches. In general, the invention provides tools that enable percutaneously dissecting the plaque from the arterial wall and removing it from the body.

The present invention relates to a monitor respiration movements device to be used on humans and also on animals for controlling the respiration movements and to control the apnea periods on infants, wherein the device reduces the mortality rate caused by the sudden instant death syndrome (SIDS), wherein the device comprises an accelerometer and a micro controller, with the accelerometer including a motion detector and a plurality of output plugs, the micro controller includes a plurality of input sockets, and wherein the plurality of output plugs are connected to the plurality of input sockets and the micro controller includes signal outputs which are connected to an alarm.

The invention relates to a sucking pig compound feed and a preparation method thereof. The feed comprises the following raw materials in parts by weight: 30-90 parts of vegetable feed raw material, 25-80 parts of vegetable puffed feed, 5-25 parts of fermentation bean pulp, 2-10 parts of fish meal, 6-30 parts of dairy product, 1-4 parts of oil, 0.2-3 parts of amino acid, 0.01-0.05 part of liquid additive and 1-3 parts of solid additive. The preparation method of the feed provided by the invention can ensure the best use of the nutrient components of different materials, can overcome the instability of enzyme agents and microbial ecological agents caused by heating, and can effectively eliminate the indigestion caused by hyposecretion of digestive enzymes before and after the weaning of thesucking pig and improve the intestinal canal health as well as the pig immunity. Through the sucking pig compound feed provided by the invention, the problem of weaning stress of the sucking pig is solved; and compared with the common piglet feed, the morbidity is greatly reduced, the feed intake and daily gain are increased, and the material-meat ratio, morbidity and mortality are reduced.

The present invention relates to novel muteins of human fibroblast growth factor 21 with improved pharmaceutical properties. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, metabolic syndrome, and in reducing the mortality and morbidity of critically ill patients.

The invention discloses a pig feed and application thereof, belonging to the technical field of sow feeding. Physiological stages of a pregnant sow are further subdivided and detailed according to physiological characteristics and nutritional requirements of the sow during a pregnancy period, the feed suitable for each stage is provided according to the nutritional requirements of the pregnant sow at each stage each day, and a reasonable and detailed feeding method is designed by combination with body conditions, feeding environments and the like of different pregnant sows, so that the exercise of the pregnant sow can be effectively increased, nutritional substances can be accurately and timely fed, the functions of a digestive absorption system and an immunity system of the pregnant sow can be promoted and improved, the number of living piglets is remarkably increased, the embryo mortality is reduced, the birth weight of the piglets is increased, and the uniformity of the piglets is improved.

This patent is an evolution of previous combination medication patents. Previous combination patents such as U.S. Pat. No. 6,613,354 which is a combination of an NSAID and Proton Pump Inhibitor. Thus the previous patents have covered gastrointestinal prophylaxis but none has covered both gastrointestinal and cardiovascular prophylaxis. This is likely because the cardiovascular side effects of NSAIDs were only recently discovered. This patent thus represents a leap in safety in a class of medication that is used by millions of Americans on a daily basis. This combination would thus decrease morbidity and mortality.

A Candida albicans bloodstream infections cause significant morbidity and mortality in hospitalized patients. Filament formation and adherence to host cells are critical virulence factors of C. albicans. Multiple filamentation regulatory pathways have been discovered, however the downstream effectors of these regulatory pathways remain unknown. The cell surface proteins in the ALS group are downstream effectors of the filamentation regulatory pathway. Particularly, Als1p mediates adherence to endothelial cells in vitro and is required for virulence. The blocking of adherence by the organism is described resulting from the use of a composition and method disclosed herein. Specifically, a pharmaceutical composition comprised of a gene, gene product, or specific antibody to the ALS gene family is administered as a vaccine to generate an immune response capable of blocking adherence of the organism.

A method of improving longevity and / or alleviating a symptom of aging or preventing age related diseases is provided. The method includes a step in which the subject's average and type of daily protein intake, IGF-I, and IGFBP1 levels, and risk factors for overall mortality, cancer and diabetes are determined. With respect to protein consumption, the relative amounts of protein calories from animal and plant sources are determined. A periodic normal calorie or low calorie but low protein fasting mimicking diet with frequencies of every 2 weeks to 2 months is provided to the subject if the subject's average daily protein intake level and type and / or IGF-I levels, and / or IGFBP1 levels is identified as being greater or lower than a predetermined cutoff intake / level and if the subject is younger than a predetermined age. The method is also shown to alleviate symptoms of chemotoxicity.

A method for preventing or treating tissue damage associated with ischemia-reperfusion injury and thoraco-abdominal aortic aneurysm (TAAA) repair by administering a tissue damage preventing or treating amount of a complement inhibitor to a patient likely to suffer from or suffering from tissue damage associated with ischemia-reperfusion injury or TAAA repair. The complement inhibitors are preferably antibodies that bind to and inhibit complement proteins involved in the formation of the membrane attach complex, preferably antibodies that inhibit MBL, MASP1, MASP2, and MASP3 in the lectin pathway. The complement inhibitors can be used alone or in combination to decrease the morbidity and mortality caused by tissue damage associated with ischemia-reperfusion injury or TAAA repair.

A retirement planning method for computing possible future values of a portfolio of an investor. In one embodiment, the method includes the steps of (a) receiving a plurality of user inputs comprising an initial value of the portfolio and a current age of the investor; (b) providing data indicating one of cumulative probabilities of living to an age of death and cumulative probabilities dying at an age of death for persons of a given age group; (c) randomly drawing a number between 0 and 1 for the investor; (d) defining the randomly drawn number as one of said one of cumulative probabilities of living to an age of death and cumulative probabilities of dying at an age of death; (e) determining an age of death of the investor in accordance with said data based on the current age of the investor and the randomly drawn number; (f) computing a future value of the portfolio using the age of death of the investor determined in step (e), a predetermined rate of return, and the initial value of the portfolio; and (g) outputting the computed future value of the portfolio.

The invention discloses a method for propagating market hogs. According to the different growth and physiological stages of the market hogs, the growth of the market hog comprises the stages of lactation and luring, weaning and stress, pigling breeding, growing development and beef gain, fodder with good nutrition, smell, and luring performance is provided in the stage of lactation and luring; fodder with diarrhea resistance and high nutrition concentration and capable of keeping the healthy of intestinal tract is provided in the stage of weaning and stress; fodder capable of strengthening immunity, promoting growth and exercising the intestinal tract is provided in the pigling breeding; fodder for increasing nutrition and protein synthesis is provided in the stage of growing development;the fodder with high energy and high amino acid is provided in the beef gain. According to the method, the fodder is schemed according to the physiology and development stage and the stress conditions; the method has the advantages of low mortality, quick growth speed, short propagation period, low feed conversion ratio, high weight and the like; in addition, the propagation cost of the market hog is lowered, and the economic benefits of propagating market hog are improved.

An manned, mobile traffic enforcement platform with aimable violation and documentation devices employing digital video and still images, incorporating contextual information as well as data input by the system operator and driver. The mobile enforcement platform (MEP) is operated by a trained and authorized system operator (typically a police officer trained and experienced in traffic enforcement) who applies pre-determined criteria, protocols, procedures and routines that are approved and authorized by the user-jurisdiction for use with the MEP system. MEP's aimable devices support detection, identification, and documentation of violations occurring in any of several lanes behind or in front of the moving MEP vehicle. MEP also can be used from the roadside. The violation information and documentation can be transmitted to a fixed facility for citation processing or it can be transferred in batches over landlines or by direct link for later citation processing. MEP is designed to capture all types of moving violations, including aggressive driving and reckless driving, in readily retrievable documentation that will support citation preparation and can even be provided with the citation to substantiate the content as required by the respective jurisdiction. The MEP operator or driver also can identify gross violations to police dispatchers for attempted interception of the violator by other police units. MEP also generates traffic-related information of interest to planners and police enforcement and can perform homeland security monitoring tasks as well as other surveillance activities. MEP is a traffic enforcement tool that is designed to greatly expand police productivity, reduce police officer paperwork and court time, increase enforcement credibility (eventually reducing court caseloads), reduce crash costs and fatalities, and dramatically improve highway safety.

The present disclosure identifies a novel subtype of follicular lymphoma (FL) characterized by dysregulation of the cyclin / CDK / RB proliferative pathway. This subtype of FL is associated with increased malignancy and mortality, relative to FL which is not associated with cell cycle dysregulation. Accordingly, this disclosure presents novel methods to subtype FL and stratify patient risk by detection of biomarkers associated with RB inactivation. This disclosure further presents novel therapies for the treatment of FL subtyped by inactivation of RB.

The disclosed methods and devices utilize various techniques to detach the distal end of a catheter from an obstruction with minimal invasiveness and effort by the surgeon. As reflux of an embolic agent or hardening material over the catheter tip is a major causative factor in the increased morbidity / mortality of embolization procedures and also a technical limitation preventing a better cure rate, a method has been developed for the detachment of the distal end of catheters within the body, preferably with no regard to the amount of reflux, and preferably at the proximal edge of the reflux, in order to be able to make embolization procedures safer and more effective.

The invention provides a total artificial method for cultivating the cordyceps sinensis, and belongs to the field of the total artificial cultivation of the cordyceps sinensis. The method comprises the steps of: a. preparing a Chinese hirsutella suspension; b. acquiring, propagating and raising the host insect; c. infecting: taking the hepialus larva obtained by the step b, and soaking the suspension of the step a by a needle-shaped apparatus with the diameter which is less than 0.2mm at one end to prick the hepialus larva to complete the infection; and d. continuously raising. After the method is used, the improper mortality of the chrysalis can be reduced, and the eclosion rate of the hepialus is improved; the mating rate of the hepialus can be improved; and the infection rate of the Chinese hirsutell to the host hepialus larvae can be greatly improved, and the total artificial industrial production of the cordyceps sinensis can be realized.

The present invention provides a new class of peptides related to rapid replication and high human mortality, and their use in diagnosing, preventing and treating disease including vaccines and therapeutics for emerging viral diseases and methods of identifying the new class of peptides and related structures.