366 results about "Psoralen" patented technology

The invention discloses a Chinese herbal livestock feed additive and the application thereof, belonging to the technical field of preparation of livestock farming feed. The Chinese herbal livestock feed additive is powder prepared from hawthorn, medicated leaven, fried malt, yam, barley, licorice, Chinese angelica, astragalus, Codonopsis, lily, Ophiopogon, Atractylodes lancea, bighead atractylodes rhizome, betel nut, Cyrtomium fortunei, Agrimonia pilosa, cortex acanthopanacis, Curculigo, Citrus aurantium, basil, mugwort, garlic powder, onion powder, Elsholtzia grass, semen cassiae, mustard Seed, Ligustrum lucidum, rangooncreeper Fruit, radish seed, psoralen, dodder and other Chinese herbs according to the conventional preparation technology. Compared with the prior art, the Chinese herbal livestock feed additive has prominent substantive features and significant advantages of capability of improving disease resistance and disease prevention, no hormone, no toxic side effect, and delicious, safe, reliable, healthy and green livestock meat.

The invention provides nutrition noodles containing Chinese medicine components and a preparation method thereof; the nutrition noodles are prepared from the raw materials which comprise flour and the following Chinese medicine components, wherein every 5kg of flour is mixed with the Chinese medicine components by weight: 4 to 10g of ginseng, 3 to 6g of radix codonopsitis, 3 to 6g of astragalus, 4 to 8g of polygonatum, 2 to 5g of atractylode, 10 to 20g of yam, 3 to 6g of rehmannia, 4 to 8g of polygonum, 3 to 8g of angelica, 4 to 10g of donkey-hide gelatin, 5 to 10g of medlar, 4 to 6g of root of herbaceous peony, 4 to 8g of radix, 3 to 6g of asparagine, 4 to 8g of polygonatum, 4 to 8g of root of straight ladybell, 10 to 15g of lily, 4 to 8g of ligustrum lucidum, 5 to 8g of psoralen, 4 to 8g of cistanche, 3 to 8g of morinda, 4 to 7g of dodder, 5 to 10g of cornus, 3 to 7g of schisandra, 3 to 7g of poria, 5 to 8g of coix seed, 3 to 6g of clove, 4 to 8g of nutmeg, 3 to 6g of fructus tsaoko, 4 to 8g of rhizoma gastrodiae, 4 to 8g of kidney tonifying nut, 3 to 6g of fructus momordicae, 10 to 20g of lotus seeds and 3 to 7g of notoginseng. The nutrition noodles have various health care effects.

This invention relates generally to systems and methods for identifying and selecting, desired proteins or nucleic acid molecules by linking mRNA, with known or unknown sequences, to its translated protein to form a cognate pair. The cognate pair is selected based upon desired properties of the protein or the nucleic acid. This method also includes the evolution of a desired protein or nucleic acid molecule by amplifying the nucleic acid portion of the selected cognate pair, introducing variation into the nucleic acid, translating the nucleic acid, attaching the nucleic acid to its protein to form a second cognate pair, and re-selecting this cognate pair based upon desired properties. Modified mRNAs operable to crosslink to tRNAs are also provided. Methods of producing a psoralen monoadduct or a crosslink are also provided.

A broad class of photosensitive compounds having enhanced in vivo target tissue selectivity and versatility in photodynamic therapy. Many furocoumarin compounds, such as psoralens, exhibit cytostatic activity when photoactivated but exhibit little in vivo specificity for selectively accumulating in any particular target tissue such as atheromatous plaques. Reactive Oxygen Producing Photosensitizers ("ROPPs") are photoactivatable compounds having an affinity for hyperproliferating cells (such as atheromatous plaque cells), which when photoactivated, produce cytotoxic reaction products. The photoactivity of a ROPP, such as a porphyrin, may be reduced by metalating the porphyrin while the selective affinity of the metalized ROPP for hyperproliferating tissue remains substantially unchanged. By linking a furocoumarin compound to a ROPP to form a F-ROPP, the cytostatic properties of the furocoumarin portion of the F-ROPP can be exploited while the selective affinity of the ROPP portion of the compound for hyperproliferating cells such as atheromatous plaque provides enhanced tissue selectivity without cytotoxicity. In vivo, certain F-ROPPs may be forced to selectively accumulate in a target tissue by illuminating only the target tissue with light having a wavelength operable for photoactivating the F portion of the F-ROPP thereby causing the F-ROPP to either form a monoadduct with or crosslink the cellular DNA in the target tissue. Light of a second wavelength can then be delivered to the target tissue to photoactivate the ROPP portion causing further interference with cellular activity.

Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition, while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix. The matrix containing the particles is contained in a housing, and the particles range in diameter from about 1 μm to about 200 μm. The matrix can be fibrous, and the particles can have a surface area greater than 750 m²/g and a pore diameter between about 25 and 800 Å. The device can be used to adsorb and remove a pathogen-inactivating compound that is a nucleic acid-binding compound such as psoralen, an acridine derivative or a dye from a biological composition such as a blood product.

A functionalized nanoparticle, having a core, optionally having a shell on at least a portion thereof, wherein the core contains a material that can convert applied X-ray energy into emitted UV energy and wherein the shell, when present, contains a plasmonics active material; wherein the nanoparticle has on a surface thereof at least one psoralen compound capable of activation by the emitted UV energy, and the use of the functionalized nanoparticle in a method of treating a cell proliferation disorder such as cancer.

The invention discloses application of psoralen as an agricultural disinfectant or pesticide. The psoralen serving as the pesticide is used for preventing and controlling lepidopterous and homopterous insects, and the psoralen serving as the disinfectant is used for preventing and controlling agricultural fungus diseases and particularly has obvious preventing and controlling effects on sclerotinia rot of colza, cucumber fusarium wilt, rice sheath blight, wheat scab and wheat sharp eyespot. The psoralen serving as the agricultural disinfectant and pesticide is characterized by good effect, broad spectrum, low toxicity, no residue, environmental friendliness and no public hazard, and is particularly favorable for environmental protection.

The invention relates to a health food made of fig, particularly to a method for producing dried figs. The method comprises the steps of selecting figs, cleaning the figs with water, peeling, neutralizing, slicing, panning and drying, fruit slicing softening, sorting out, classifying and packing. The invention has the characteristics that the equipment required for the invention is relatively simple, the production technology is easy to learn, and the method can keep the product nutritional, fresh and delicious for a long period. Fig is known for containing a large amount of anti-cancer substances, such as selenium, phenyl aldehyde, bergaptol, psoralen, etc., so that the regular consumption of fig can improve immune system of human body, prevent health problems such as cardiovascular disease and cancer, and serve the purpose of regulating blood pressure.

The invention discloses a kidney-nourishing and yang-strengthening tea which is prepared from the following components in parts by weight: 100-120 parts of green tea, 5-7 parts of pilose antler, 5-7 parts of red ginseng, 5-7 parts of tuckahoe, 5-7 parts of yam, 5-7 parts of angelica, 5-7 parts of rhizoma chuanxiong, 5-7 parts of psoralen, 5-7 parts of achyranthes, 5-7 parts of schisandra, 5-7 parts of wild jujube, 5-7 parts of polygalaceae, 5-7 parts of morinda officinalis, 5-7 parts of male moths, 5-7 parts of atractylis ovata, 5-7 parts of dodders, 5-7 parts of frutus cnidii, 5-7 parts of rhizoma curculiginis, 5-7 parts of herba cistanches, 5-7 parts of herba epimedii and 5-7 parts of cynomorium songaricum. The kidney-nourishing and yang-strengthening tea can comprehensively improve and enhance the body immunity, nourish and tonify the kidney, co-supplement vital essence and rapidly strengthen virile physical strength, energy and kidney power, and has the efficacy of nourishing the kidney, strengthening the body, refreshing the mind, restoring consciousness, quenching thirst, releasing fatigue, refocillating, benefiting muscular and skeletal action and delaying aging.

A method to encompass a citrus-based cream or gel composition that is highly stable and all-natural from components in situ by removing undesired components from citrus, producing such cream or gel with desired components and texture according to intended use, either as a cosmetic or medicinal lotion, a cream base, or as a food ingredient with nutraceutical and/or binding properties for use in as example analogue meats. The method comprises the steps of grinding whole citrus fruit or peel adjusted via rate of heating and pH to optimize gel consistency and desired residual bioflavonoids rather than maximizing pectin production. Citrus-derived components such as, but not limited to, d-limonene, naringin, and psoralen are added to and blended with the gel for applications which require concentrations higher than found in vivo.

The invention relates to an agricultural bactericidal agent, especially relating to an agricultural bactericidal agent prepared with extract of psoralen to prevent rice blast for rice, late blight for tomato and potato, chilli epidemic disease and gray mold for cucumber and so on. The total extract of psoralen can be got by chemical extracting method, for example, extracting with ethanol of 95%, or methanol or water or organic solvent from psoralen seed powder, then condensing and getting the total extract. Dissolving the total extract in water or acetone or dimethyl sulfoxide or organic solvent to prepare mother liquid. The bactericidal agent is characterized by high efficiency, low toxicity and residual and hard for drug resistance.

The invention provides a method for detecting coumarin series compounds, which comprises the following steps that: ultra high-efficiency liquid chromatography and tandem mass spectrometry detection are carried out to a sample, so as to determine the types and the content of coumarin series compounds contained in the sample. The coumarin series compounds comprise one or more types in vinegar Glass coumarin, dicoumarol, 6-methoxy-7-hydroxy coumarin, 7-hydroxycoumarin, 8-hydroxy-psoralen, 4-methyl-7-hydroxy coumarin, 6,7-dimethoxy coumarin, coumarin, 7-methoxy coumarin, dihydro coumarin, psoralen, psoralen, 8-methoxypsoralen, 7-methyl, 5-methoxypsoralen, 4-methyl-7-ethoxyl coumarin, 4-methyl-7-diethylamino coumarin, 2', 4,8-trimethyl psoralen, imperatorin, isoimperatorin, columbianadin and cyclocoumarol. The method of the invention can complete the analysis and the detection of 22 coumarin series compounds within 4 min.

A Chinese medicine in the form of effervescent tablet for treating osteopathy is prepared from 6 Chinese-medicinal materials including epimedium, dipsacus root, red sage root, rehmannia root, etc through extracting, mixing with auxiliary and tabletting.

A composition including an aliquot of the herb Herba Epimedii; and an aliquot of at least three supplemental herbs selected from the group consisting of Fructus Rosae Laevigatae; Fructus Rubi; Fructus Psoralea; Radix Morindae Officinalis; Fructus Schisandrac Chinensis; Fructus Ligustri Lucidi; Semen Cuscutae; and Radix Astragali. A composition including icariin; ursolic acid; ellagic acid; psoralen; deoxyschizandrin; oleanolic acid; quercetin; aslvagaloside; and an extract of the herb Radix Morindae Officinalis. Methods including administering a composition directed at treatment of various kidney disorders or the promotion of kidney health and to the overall health of the kidney, including the use of a composition in the treatment of prostate cancer, prophylatic prostate health, reduction of polyuria, incontinence, proteinuria, as well as for sexual satisfaction.

A traditional Chinese medicine for curing nettle rash, clearing heat and rash removing belongs to a traditional Chinese medicine for curing nettle rash. Prescription: 6g of Chinese wolfberry root-bark, 10g of white mulberry root-bark, 10g of poriae cortex, 3g of ginger peel, 12g of radix rehmanniae, 6g of broom cypress fruit, 10g of forsythia, 10g of burdock, 12g of radix paeoniae rubra, 10g of spicaprunellae, 6g of periostracum cicadae and 6g of psoralen. The substances in the prescription are made from natural traditional Chinese medicine plus traditional preparing methods. The materials are easy to collect, the prescription and the preparation methods are simple, and the cost of medicine preparation is low. The compatibility of the traditional Chinese medicine is simple; the medicine used in the prescription is fully natural herbal medicine, which is easy to collect and use; the preparation method is simple; the effects for taking and curing are good; the cost of the medicine is low, and the medicine is in particular suitable for the people living in remote villages far from towns; the cost is low for curing the people suffering from nettle rash, which solves the problem that the local area lacks medical conditions to cure the disease because of low household income and poor living condition.

The invention relates to a traditional Chinese medicine external rubbing preparation for hair growth and black hair, which belongs to the field of traditional Chinese medicine for external use. It is a type A extract prepared by immersing 6% of Baibu, 6% of Eclipta, 6% of Polygonum multiflorum, and 12% of side louver into ethanol. Psoralen 11.6% was immersed in ethanol to obtain type B extract, 4% peach kernel, 4% safflower, and peppermint were immersed in ethanol to obtain type C extract, and then A, B, and C were mixed with each other. Mix and store in an airtight container for 30 days. The preparation does not contain any chemical components harmful to the human body, and can make the hair of alopecia patients grow rapidly and the hair of patients with white hair turn black. The problem of large side effects, insignificant curative effect and long treatment time of the currently used medicines for treating hair loss and white hair is solved. The liniment is simple to use and low in production cost, and is suitable for various hair loss patients and middle and early gray hair patients.

A process for preparing ficusin and isoficusin used to prepare the medicine for preventing and treating gastric cancer includes pulverizing psoralea as raw material, immersion extracting in chloroform three times, vacuumizing, recovering solvent to obtain extract, adding silica gel, stirring, low-temp baking, grinding, separation extracting by chromatographic column, gradient eluting with petroleum ether-ethyl acetate solution, vacuum distilling, and laying aside for crystallizing.

The invention relates to a method for preparing psoralen and isopsoralen or an extract containing psoralen and isopsoralen. Particularly the method comprises the steps of (i) conducting backflow extraction on fructus psoraleae medicinal materials by using water, and concentrating a combined extracting solution to obtain a concentrated solution; (ii) adding acid in the obtained concentrated solution, heating and hydrolyzing; (iii) eluting hydrolysate on a macroporous adsorption resin by using water to remove impurities, eluting by using ethanol water solution with concentration larger than 50%, collecting an ethanol eluant, and concentrating or optionally drying further to obtain the extract containing psoralen and isopsoralen; and (iv) optionally subjecting the extract obtained in the step (iii) to a silicagel column, eluting by using an organic solvent, collecting psoralen fraction and isopsoralen fraction, and removing the solvent to respectively obtain psoralen and isopsoralen. The method is simple in operation, short in production period, high in yield, less in pollution and applicable to industrialization mass production.

The invention discloses a cloud point extraction based psoralen and isopsoralen extracting method. The method comprises the following steps: fully mixing Psoralea corylifolia powder with a surfactant solution, and extracting under an ultrasonic condition; collecting the obtained extract liquid after extracting completion, centrifuging, collecting the obtained supernatant, adding an electrolyte for adjusting the ion intensity, balancing in a constant temperature water bath, and allowing the supernatant obtained after the centrifugation to stand in order to obtain an aqueous surfactant solution layer and a surfactant enrichment layer; and filtering the surfactant enrichment layer by an ultrafilter membrane after the two-phase layering, recovering the surfactant, and carrying out rotation evaporation of the obtained filtrate to obtain a fat-soluble crude extract containing psoralen and isopsoralen. The method has the advantages of no need of toxic harmful organic solvents, extracting rate increase, environmental pollution reduction, and suitableness for the industrialized large-scale extraction.

A method of treating chronic HCV infections is disclosed. The method involves the optional treatment of a patient with interferon alpha and the treatment of a patient's blood with a psoralen compound followed by ultra violet light-activation of the psoralen compound. The blood treated as such is returned to the patient in a process known as extracorporeal photopheresis.

The invention discloses a fish bait for catching grass carps. The fish bait consists of parslane herb, psoralen, golden thread, ciderage, cyperus rotundus, sulphur, duckweed powder, drawing powder, food-promoting agent powder for fishes, corn puffed powder, unhulled rice and fresh earthworms. The former five materials are spread out and dried in the sun, are mixed according to proportions and then are crushed into powder; the powder is filled in a container; the container is sealed; the sulphur is ground into powder; the earthworms are cut into sections of which the length is 2 centimetres for later use; the unhulled rice is cooked with water in a boiler until the hulls are open, wherein the additive amount of the water is determined to ensure that no water drips after the unhulled rice is cooked; the cooked unhulled rice is dispersed when the rice is warm; the prepared mixed powder of the parslane herb, the psoralen, the golden thread, the ciderage and the cyperus rotundus is added onto the cooked unhulled rice in the boiler; the boiler is sealed for 3 to 4 hours; the sulphur, the duckweed powder, the drawing powder, the food-promoting agent powder for fishes, the corn puffed powder, the unhulled rice and the fresh earthworms are completely poured into the boiler; the materials are stirred uniformly; the mixture is filled into a big plastic bag; and the bag is sealed.

This invention relates generally to systems and methods for identifying and selecting, desired proteins or nucleic acid molecules by linking mRNA, with known or unknown sequences, to its translated protein to form a cognate pair. The cognate pair is selected based upon desired properties of the protein or the nucleic acid. This method also includes the evolution of a desired protein or nucleic acid molecule by amplifying the nucleic acid portion of the selected cognate pair, introducing variation into the nucleic acid, translating the nucleic acid, attaching the nucleic acid to its protein to form a second cognate pair, and re-selecting this cognate pair based upon desired properties. Modified MRNAs operable to crosslink to tRNAs are also provided. Methods of producing a psoralen monoadduct or a crosslink are also provided.