Phototherapeutical apparatus and method for the treatment and prevention of diseases of body cavities

a technology of body cavity and phototherapy, which is applied in the field of can solve the problems of unsolved treatment and prevention of inflammatory diseases of the nasal mucous membrane and paranasal sinuses, increase the cost of direct and indirect disease, and increase the direct microbicidal activity of epithelial cells. , to achieve the effect of enhancing the killing activity of candid

Inactive Publication Date: 2006-06-22
KEMENY LAJOS +5
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The treatment and prevention of inflammatory diseases of the nasal mucous membrane and paranasal sinuses is an unsolved problem.
Because of the high number of patients the direct and indirect costs of this disease are great.
Although hay fever is not a very severe disease, its unpleasant symptoms worsen the quality of life considerably.
However, the presently available drugs often do not eliminate the symptoms.
However, the Saalmann Cup can not be introduced into smaller body cavities because of its large contact area and because of the thickness of the used fiber optic cable.
For this reason, this device is unsuitable for the treatment of body areas, which cannot be visually controlled, such as the nasal and paranasal mucous membrane, the gastrointestinal, and the urogenital mucous membrane.
Although ultraviolet light has been used for the treatment of hyperproliferative and inflammatory skin diseases for many years, it has not been used for the treatment of common, immunologically mediated disorders of the nasal mucous membrane.
However, the intense ultraviolet light damages the tissues with its ablative effect.
However, in these instruments no ultraviolet light is used, and they have special distal ends for tumor treatment (U.S. Pat. Nos. 4,313,431; 4,612,938; 4,676,231; 4,998,930; 5,146,917).
As such, they are either unsuitable or inconvenient for the treatment of small body cavities such as the nasal cavity with visual control.
Ultraviolet lasers are suitable for this purpose, but they are expensive.

Method used

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  • Phototherapeutical apparatus and method for the treatment and prevention of diseases of body cavities
  • Phototherapeutical apparatus and method for the treatment and prevention of diseases of body cavities
  • Phototherapeutical apparatus and method for the treatment and prevention of diseases of body cavities

Examples

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Effect test

example 1

[0100] The symptoms of a patient suffering from ragweed-induced hay fever 10 years ago did not respond to the used antihistamine and topical corticosteroid nasal drops satisfactorily. At examination the patient complained of severe nasal blockage, nasal itching, nose running, frequent sneezing and itching of the nasal palate. On an area of the back of the patient, which was not recently exposed to sunlight, the minimal erythema dosis (MED) was determined to be about 200 mJ / cm2, using a 308 nm xenon chloride laser as ultraviolet light source. One day later the phototherapy of the nasal mucous membrane was started. For this purpose ultraviolet light beam 2 of ultraviolet light source 1 was directed by optical focusing into optical guidance system 4. Optical guidance system 4 was an optical cable made of quartz and it had a diameter of 1.6 mm. The optical cable was connected to patient interface 5 of the type shown in FIG. 4. Output window 26 of patient interface 5 included a plano-par...

example 2

[0102] Phototherapeutical treatment was also performed on patients with perennial allergic rhinitis, which was induced by house dust mite and whose treatment with antihistamine and local steroids proved to be ineffective. The phototherapy was performed with xenon chloride excimer laser of wavelength of 308 nm.

[0103] The MED was measured for each patient and phototherapy was started with 0.5×MED doses. Circular applicator head 34 for cylindrically symmetric treatment was inserted into the meatus nasi inferior area of the nasal cavity for the treatment, then a cylindrically symmetric irradiation was administered onto the tissue surface with the xenon chloride laser. The length of impulses was 15 ns, the frequency of irradiation was 10 Hz. The energy density of each impulse was 2 mJ / cm2. The administering of the dose of 100 mJ / cm2 took 5 seconds. Circular applicator 34 was then inserted into middle and thereafter into the upper part of the nasal cavity and the treatment was repeated i...

example 3

[0104] The severe symptoms of a patient suffering from ragweed-induced hay fever did not improved satisfactorily after using antihistamines and topical corticosteroid nasal drops. At examination the symptoms (nasal blockage, nasal itching, nose running, frequent sneezing, and itching of the nasal palate) of the patient were severe, therefore phototherapeutical method 200 was performed with photochemotherapy. The minimal phototoxicity dose was measured on the forearm of the patient not exposed to sunlight. Ultraviolet light source 1 of the type shown in FIG. 2 was used for the irradiation in a way that two ultraviolet light beams of wavelengths between 310 and 350 nm were coupled into optical guidance system 4 through optical filters. The MPD was 500 mJ / cm2 and the treatment of the nasal mucous membrane was started with a dose of 2.0×MPD (=1000 mJ / cm2) using patient interface 5 shown in FIG. 4. Photochemotherapy was performed after using 8-methoxypsoralen nasal spray. Head 25 of pati...

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Abstract

A phototherapeutical apparatus and method are described. The apparatus includes an ultraviolet light source, an optical guidance system, and a patient interface. The patient interface is insertable at least partially into a body cavity and is operable to apply the guided ultraviolet light to a tissue surface of a body cavity. The method includes providing the phototherapeutical apparatus, preparing for the application of the phototherapeutical apparatus, inserting the patient interface at least partially into a body cavity, and applying the ultraviolet light by the patient interface to a tissue surface of a body cavity, wherein the tissue of the body cavity has an inflammatory or a hyperproliferative disease. The inflammatory diseases include rhinitis, sinusitis and rhinosinusitis. A photochemotherapeutical method is also described, using photosensitizing substances, such as psoralen before treatment with ultraviolet light. The phototherapeutical method is also effective for the prevention of inflammatory or hyperproliferative diseases.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a continuation of U.S. application Ser. No. 10 / 410,690, filed Apr. 9, 2003, which is a continuation of International Application No. PCT / HU01 / 00102, filed Oct. 24, 2001, which claims priority from Hungarian Application No. P0103279, filed Aug. 10, 2001, all of which are incorporated herein by reference.BACKGROUND [0002] 1. Field of the Invention [0003] The present invention relates to the treatment and prevention of inflammatory and hyperproliferative diseases of body cavities, more particularly to the treatment and prevention of diseases of the nasal cavity by phototherapeutical methods. [0004] 2. Description of the Related Art [0005] The treatment and prevention of inflammatory diseases of the nasal mucous membrane and paranasal sinuses is an unsolved problem. These diseases include allergic rhinitis, commonly referred to as hay fever, vasomotor rhinitis, non-allergic eosinophilic rhinitis, chronic sinusitis, which...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61N5/06A61B18/20A61N5/067
CPCA61N5/0601A61N5/0603A61N5/062A61N2005/0605A61N2005/0606A61N2005/0607A61N2005/0608A61N2005/0609A61N2005/0611A61N2005/0644A61N2005/0661A61N2005/067A61N5/067
Inventor KEMENY, LAJOSBOR, ZSOLTSZABO, GABORIGNACZ, FERENCRACZ, BELADOBOZY, ATTILA
Owner KEMENY LAJOS
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