33 results about "Sinusitis" patented technology

The present invention provides a Lactiplantibacillus plantarum strain capable of resisting Streptococcus pneumoniae infection in the respiratory tract, with a deposit number of CCTCC NO: M2022359. The Lactiplantibacillus plantarum VHProbi P06 strain provided by the present invention has a strong adhesion effect on nasal epithelial cells and can colonize in the nasal cavity; and can significantly inhibit the adhesion effect of Streptococcus pneumoniae, the main pathogenic microorganism of sinusitis, on nasal epithelial cells; it also has an inhibitory effect on the growth of most other pathogenic microorganisms of sinusitis, including β-hemolytic streptococcus, Streptococcus pyogenes, Escherichia coli, Staphylococcus aureus, etc. The Lactiplantibacillus plantarum VHProbi P06 strain provided by the present invention has no toxic effect on the body and has good safety. It can be added to drugs for preventing respiratory diseases or improving respiratory symptoms caused by bacterial infections, and has broad application prospects.

The utility model provides an atomizing mask. The atomization cover comprises a cover body, a medicine inlet pipe and a breathing hole, the cover body is worn on the face of the human body, the medicine inlet pipe is connected to the cover body, and the breathing hole is formed in the cover body. The shielding assembly comprises a shielding plate and a plurality of mounting parts, the mounting parts are detachably mounted on the medicine inlet pipe, and the shielding plate is mounted on the mounting parts, shields the mouth of the human body and is configured to abut against the mouth of the human body under the action of the mounting parts. The utility model further provides an atomizer which comprises an atomizing mask and an atomizer body, and the atomizer body is detachably installed at the end, away from the shielding plate, of the medicine inlet pipe. According to the atomization mask, when rhinitis, nasosinusitis, bronchitis, pneumonia and other diseases are treated, liquid medicine is prevented from flowing back into the oral cavity of a user, it is guaranteed that the atomized liquid medicine is sucked into the airway of a patient as much as possible, the treatment effect of the device is improved, and the treatment effect is improved. The liquid medicine can be prevented from entering the oral cavity, so that the use comfort of a user is reduced, and bacterial infection is avoided.

The application discloses an ear-nose-throat department rhinitis and rhinosinusitis nasal cavity flushing device, and belongs to the technical field of medical instruments, which comprises a flushing liquid injection mechanism and an inner-outer cannula breathing mechanism which are used in cooperation, wherein the flushing liquid injection mechanism comprises a liquid storage bag and a first conducting pipe, the first conducting pipe is connected with the liquid storage bag through a liquid delivery pipe, a nasal cavity liquid supply assembly and a nasal cavity foreign matter cleaning assembly are arranged on the first conducting pipe, and the nasal cavity liquid supply assembly is used in cooperation with the liquid delivery pipe; the inner-outer cannula breathing mechanism comprises a second conducting pipe, and a flushing liquid discharge assembly and a positioning assembly are arranged on the second conducting pipe; through the arrangement of the flushing liquid injection mechanism and the inner-outer cannula breathing mechanism, the device can effectively clean the nasal cavity of a patient, meets the demand of different cleaning modes, and has the characteristics of good cleaning effect, simple and convenient use and low manufacturing cost.

The present invention relates to a patch (1) for the topical treatment of sinusitis in a person to be treated, the patch (1) comprising at least one active section (2) with at least one active ingredient and at least one adhesive section (3), wherein the patch (1) is designed to be at least partially, preferably completely, occlusive in the at least one active section (2) and / or in the at least one adhesive section (3), wherein it is provided according to the invention that the at least one active section (2) contains a therapeutically effective amount of a non-steroidal anti-inflammatory drug and / or its physiologically compatible compounds / salts and / or physiologically compatible chemical derivatives as the at least one active ingredient, and that the patch (1) has a shape that is adapted to the anatomical conditions of the application site, wherein the application site is in the face in the area of ​​at least one of the paranasal sinuses,preferably located in the area of ​​the cheek of the person to be treated, in order to enable targeted percutaneous treatment of the sinusitis.

The present invention discloses a composition for improving rhinitis symptoms and nasal cleaning, as well as its preparation method and application. The composition comprises, by weight, 0.1 to 7 parts of yeast β-glucan and 0.1 to 6 parts of mussel mucin. The present invention prepares a composition for improving rhinitis symptoms and nasal cleaning by rationally combining ultra-low molecular weight yeast β-glucan, low molecular weight yeast β-glucan, medium molecular weight yeast β-glucan, high molecular weight yeast β-glucan, and mussel mucin. The composition can be effectively used for nasal cleaning of patients with nasal diseases such as acute rhinitis, chronic rhinitis, allergic rhinitis, nasal polyps, sinusitis, etc., and can also be used for nasal cleaning after nasal tumor surgery or chemotherapy.

The invention provides magnolia denudata compound essential oil as well as a preparation method and application thereof, and the magnolia denudata compound essential oil comprises the following components in parts by mass: 30-40% of magnolia denudata essential oil, 15-20% of peppermint oil, 5-10% of fructus forsythiae oil, 8-10% of radix angelicae oil, 5-8% of radix saposhnikoviae oil, 5-8% of eucalyptus oil, 5-8% of ligusticum wallichii oil, 5-10% of lavender oil and 5-10% of agastache rugosus. The total percentage is 100%. The product provided by the invention can be applied to nasal products such as snorting, nasal stickers and nasal cleaning rods, relieving poor breath caused by acute nasosinusitis, nasal obstruction and headache caused by cold, relieving pressure and anxiety, refreshing and the like. The traditional Chinese medicine composition is extracted from pure plants, has no adverse reaction, can relieve poor breath caused by acute nasosinusitis and nasal obstruction and headache caused by cold at the same time, can relieve pressure and anxiety, and can refresh mind and restore consciousness.

A method for treating a narrowed region of a lumen in a patient's ear or nose is described herein. The method includes advancing a catheter within the lumen such that a distal end of the catheter is positioned proximate the narrowed region, filling a fillable member to cause the fillable member to expand within the lumen, and generating at least one shockwave from at least one shockwave emitter. The at least one shockwave creates one or more fractures in a bone structure of the narrowed region of the lumen that causes the narrowed region to expand.

The invention provides systems and methods for therapeutically modulating nerves in or associated with a nasal region of a patient for the treatment of a rhinosinusitis condition. The method includes providing a treatment device comprising a treatment comprising a plurality of electrodes and advancing the treatment element into the nasal cavity of a subject such that two or more of the plurality of electrodes of the treatment element are positioned relative to targeted neural tissue within the nasal cavity. The method further includes controlling, via a console unit operably coupled to the treatment device, delivery of one or more treatment applications applied via the treatment element for altering transmission of signals through the targeted tissue.

This invention relates to the application of a traditional Chinese medicine composition in the preparation of a drug for sinusitis. The composition is characterized by being prepared from ephedra (processed with honey), bitter almond, perilla seed, prepared pinellia, licorice, scutellaria, angelica, belamcanda, coltsfoot flower, mulberry bark, cicada slough, silkworm, and earthworm. The composition of this invention improves sinusitis symptoms, reduces inflammation levels, and regulates the pH of nasal secretions in a sinusitis model prepared by Staphylococcus aureus, suggesting that this traditional Chinese medicine composition has a good therapeutic effect on sinusitis.

This invention relates to an antisense oligonucleotide targeting the interleukin-4 receptor and its applications. The antisense oligonucleotide (ASO) molecule is 16-22 bases in length and specifically pairs with a specific region of the target gene (interleukin-4 receptor). The ASO is used to treat diseases related to IL-4Rα, including but not limited to asthma (including eosinophilic types), atopic dermatitis, eosinophilic esophagitis, sinusitis, nasal polyps, nodular prurigo, urticaria, COPD, bullous pemphigoid, pruritus, and gastritis.

The invention discloses a traditional Chinese medicine composition for treating nasosinusitis, an external ointment and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 45 to 55 parts of flos magnoliae liliflorae, 55 to 65 parts of radix angelicae, 25 to 35 parts of flos genkwa, 45 to 55 parts of fructus gleditsiae, 75 to 85 parts of leech, 115 to 125 parts of maggot, 95 to 105 parts of centipeda minima, 25 to 35 parts of fructus xanthii, 55 to 65 parts of muskmelon base, 25 to 35 parts of herba asari, 15 to 25 parts of borneol, 5 to 15 parts of menthol and 15 to 25 parts of sal ammoniac. The biond magnolia flower and the cocklebur fruit are used as monarch drugs, the radix angelicae, the centipeda minima and the asarum are used as ministerial drugs, the lilac daphne flower bud, the leech, the maggot, the muskmelon base, the fructus gleditsiae and the sal ammoniac are used as adjuvant drugs, and the borneol and the menthol are used as conductant drugs, so that a compound structure of dredging orifices, expelling pus and guiding channels is formed, and the traditional Chinese medicine composition is suitable for phlegm-heat congestion type nasosinusitis and is quick in effect and high in cure rate.

A composition comprising isolated Streptococcus pyogenes extracellular vesicles (EVs) suspended in a vehicle, for use in eliciting an adaptive immune response against group A streptococcus (GAS) in a subject. The EVs may comprise antigens MtsA, Spy_1228, PrsA1, PrsA2, SPy_0319 and / or GlnP. A composition comprising isolated S. pyogenes protein(s) MtsA, SPy_1228, PrsA1, PrsA2, GlnP, SPy_0319 and / or MalX. The compositions may be used for inducing protective immunity in a subject against a GAS infection, such as streptococcal pharyngitis, scarlet fever, impetigo, streptococcal meningitis, streptococcal sinusitis, necrotizing fasciitis, cellulitis, streptococcal toxic shock syndrome, rheumatic fever and post-streptococcal glomerulonephritis.

This invention is a high-potency medicinal oil composition and industrial processing method designed to prevent and treat acute and chronic respiratory tract infections, including sinusitis and tonsillitis, in a manner that breaks down the drug-resistant properties of pathogens (Antimicrobial A89. የ65ራርት1ረሰ6). The invention has a well-established framework for producing a precise 1 liter (1000 ML) pure liquid product with consistent quality.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a traditional Chinese medicine composition for treating chronic rhinitis-sinusitis, its preparation method, and its uses. The traditional Chinese medicine composition is made from Codonopsis pilosula, Astragalus membranaceus (processed), Atractylodes macrocephala (processed), Ligustrum lucidum, Magnolia biondii, Xanthium sibiricum (processed), Angelica dahurica, Ligusticum chuanxiong (processed), Platycodon grandiflorus, Cinnamomum cassia, Saposhnikovia divaricata, Glycyrrhiza uralensis (processed), and Asarum heterotropoides. This traditional Chinese medicine composition has the effects of clearing the lungs and dispelling pathogens, strengthening the spleen and replenishing qi, and draining pus and opening the nasal passages, showing significant therapeutic effects on chronic rhinitis-sinusitis. Furthermore, the preparation method of this traditional Chinese medicine composition has the advantages of simple preparation process, high efficiency, energy saving, and minimal destruction of effective components.

The invention discloses a traditional Chinese medicine composition for treating rhinitis and nasosinusitis and a preparation thereof, and relates to the technical field of traditional Chinese medicine preparations, and the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 3-5 parts of honeysuckle, 1-3 parts of ginseng, 1-3 parts of radix angelicae, 0.5-2 parts of ligusticum wallichii, 0.5-2 parts of salvia miltiorrhiza, 0.5-2 parts of magnolia flower, 0.5-2 parts of rhizoma zingiberis, 0.5-2 parts of divaricate saposhnikovia root and 0.5-2 parts of ephedra. Through a synergistic effect mechanism of oral administration and external use, a new choice is provided for treatment of rhinitis and nasosinusitis. All the medicinal materials in the oral composition are reasonable in compatibility, and common symptoms such as nasal obstruction and runny nose can be relieved; the external preparation can directly act on local nasal cavity, and the mild preparation form is beneficial for patients to accept and use for a long time.

This invention provides a method for preparing a thermosensitive gel for the prevention and treatment of nasal diseases and its application. By weight and volume percentage, it comprises recombinant human type III collagen, mussel adhesive protein, an anti-allergy agent, traditional Chinese medicine extracts, thermosensitive materials, and a sodium pyruvate-cocamidopropyl betaine ion-pair complex. This invention, by pre-forming the ion-pair complex, simultaneously solves the technical problems of existing nasal gels, such as poor anti-dilution ability, short adhesion time, and easy inactivation of active ingredients. The product is liquid below 30°C and can be sprayed for complete nasal coverage. At body temperature, it transforms into a gel within 2 minutes for long-lasting adhesion, exhibiting rapid anti-inflammatory, nasal patency-clearing, antipruritic, and mucosal repair effects. It is suitable for the prevention and treatment of allergic rhinitis and sinusitis, as well as nasal wound care, with significantly better efficacy than similar commercially available products.

A set of antisense oligonucleotides specifically inhibiting thymic stromal lymphopoietin and the use thereof. The antisense oligonucleotide molecules have a length of 16-20 bases. The antisense oligonucleotide molecules have the following use: (1) in the preparation of a preparation for inhibiting the expression level of thymic stromal lymphopoietin; or (2) in the treatment of asthma, atopic dermatitis, chronic obstructive pulmonary disease, sinusitis, and nasal polyps.

The invention provides systems and methods for therapeutically modulating nerves in or associated with a nasal region of a patient for the treatment of a rhinosinusitis condition. The method includes providing a treatment device comprising a treatment comprising a plurality of electrodes and advancing the treatment element into the nasal cavity of a subject such that two or more of the plurality of electrodes of the treatment element are positioned relative to targeted neural tissue within the nasal cavity. The method further includes controlling, via a console unit operably coupled to the treatment device, delivery of one or more treatment applications applied via the treatment element for altering transmission of signals through the targeted tissue.

Diagram "Algorithm for the diagnosis and treatment of post-implantation sinusitis that occurs after sinus lift and dental implantation"

The invention discloses a CRSwNP paranasal sinus automatic segmentation and intrinsic type prediction method and system based on a CT image, and the method is characterized in that the method comprises the steps: collecting a paranasal sinus CT image comprising an axial position layer, a coronal position layer and a sagittal position layer, marking a paranasal sinus region, marking an intrinsic type label, generating and converting the paranasal sinus region into a paranasal sinus 3D image, and forming a CRSwNP image database; the intrinsic type labels comprise eosinophilic type labels and non-eosinophilic type labels; designing a 3D multi-task classification segmentation network model for receiving a 3D paranasal sinus CT image and predicting an intrinsic type category and a paranasal sinus region; training the 3D multi-task classification segmentation network model by using a CRSwNP image database to obtain a prediction model; and predicting the paranasal sinus area and the intrinsic type of nasosinusitis with nasal polyp in the 3D paranasal sinus CT image by using the prediction model. According to the method, automatic segmentation of the paranasal sinus 3D model based on the CT image is realized, and accurate prediction of the CRSwNP intrinsic type is carried out on the basis of the paranasal sinus 3D model, so that a clinician can be guided to carry out individualized accurate treatment.

This invention relates to a group of antisense oligonucleotides that specifically inhibit thymic stromal lymphopoietin and their applications. The antisense oligonucleotide molecules are 16-20 bases in length. This invention also relates to the following applications of the antisense oligonucleotide molecules (ASO): (1) preparing preparations that inhibit the expression of thymic stromal lymphopoietin; (2) treating asthma, atopic dermatitis, COPD, sinusitis and nasal polyps.

The present invention relates to the field of medical devices, specifically a maxillary sinus natural opening exploration and expansion kit. Currently, nasal endoscopic surgery is used to treat sinusitis and other diseases, and the uncinate process is usually removed to achieve the patency of the maxillary sinus natural opening, which has many impacts on the patient's postoperative recovery, nasal cavity and sinus function, etc. The technical solution of the present invention includes a probe and expander and an aspirator combination of a curved rod and a curved tube structure. The structural design conforms to the overall spatial structure of the human nasal cavity, maxillary sinus, and sinus orifice and nasal meatus complex. For most patients in clinical practice, this device can avoid the interference of nasal cavity structures such as the front end of the middle turbinate on the treatment operation, and achieve the exploration and expansion of the maxillary sinus natural opening while retaining the uncinate process, and use the aspirator to flush and administer medicine to the maxillary sinus cavity. The patient does not need to be hospitalized for surgery, which avoids the impact of surgical treatment on the patient's future life, greatly reduces the pain and damage during the treatment process, and alleviates the economic and psychological burden of the patient, which is in line with the concept of minimally invasive surgery.

This invention discloses a method for constructing a sinusitis regulation analysis model based on nasal polyp cell inhibition data, belonging to the field of CRSwNP disease analysis technology. The method includes the following steps: collecting Lund-Kennedy scores and corresponding nasal polyp cell inhibition data from CRSwNP patients to obtain raw sample data; screening the raw sample data to remove unqualified raw sample data from CRSwNP patients to obtain standard sample data; performing index preprocessing based on the standard sample data and obtaining the optimal lag order to obtain reference sample data; constructing an LK analysis prediction model based on the reference sample data and analyzing and predicting the Lund-Kennedy scores of CRSwNP patients. This invention addresses the problem that existing CRSwNP disease analysis technologies cannot provide clinicians with objective and reliable analytical and predictive tools when analyzing and predicting the Lund-Kennedy scores of CRSwNP patients, thus failing to help clinicians reliably predict the disease progression of CRSwNP patients during treatment.

The application discloses a method for stereoscopic reconstruction and visualization of nasal polyp tissue based on artificial intelligence recognition of continuous pathological sections, which comprises the following steps: strict continuous section of a reconstruction object; HE staining of the continuous sections; affine registration of the continuous pathological sections; one-by-one analysis of the registered continuous pathological sections; stacking according to the registration sequence, then processing, to obtain three-dimensional model data of the nasal polyp tissue structure; and visual rendering of the three-dimensional model data of the nasal polyp tissue structure, combined with a preliminary stereoscopic model, to obtain a final stereoscopic model of the nasal polyp tissue structure. The method can reconstruct and visualize the nasal polyp tissue, and can show the three-dimensional structure of the distribution characteristics of inflammatory cells and tissue structure of the nasal polyp in the spatial structure, so that the morphological structure content of the nasal polyp tissue is enriched, and morphological basis is provided for further exploring the occurrence and development mechanism of chronic rhinosinusitis with nasal polyps.

Provided is a method for treating a TSLP-associated inflammatory disease (e.g., nasal polyp and / or sinusitis) using an anti-TSLP antibody or an antigen-binding fragment thereof and pharmaceutical use.

The invention discloses a nasal cavity flushing device for rhinitis and nasosinusitis in the otolaryngology department, and belongs to the technical field of medical instruments.The nasal cavity flushing device comprises a flushing fluid injection mechanism and an inner and outer sleeve breathing mechanism which are used in cooperation, the flushing fluid injection mechanism comprises a fluid storage bag and a first communicating pipe, and the first communicating pipe is connected with the fluid storage bag through a fluid conveying pipe; a nasal cavity liquid feeding assembly and a nasal cavity foreign body cleaning assembly are arranged on the first conduction pipe, and the nasal cavity liquid feeding assembly is used in cooperation with the liquid feeding pipe; the inner and outer sleeve breathing mechanism comprises a second conduction pipe, and a flushing fluid discharge assembly and a positioning assembly which are arranged on the second conduction pipe; through the arrangement of the flushing fluid injection mechanism and the inner and outer sleeve breathing mechanism, the nasal cavity of a patient can be effectively cleaned, the requirements of different cleaning modes are met, and the nasal cavity cleaning device has the advantages of being good in cleaning effect, easy and convenient to use and low in manufacturing cost.

The invention discloses a nasal polyp tissue three-dimensional reconstruction and visualization method based on artificial intelligence recognition of continuous pathological sections. The method comprises the following steps: strictly and continuously slicing a reconstruction object; carrying out HE staining on the continuous sections; performing affine registration on the continuous pathological sections; analyzing the registered continuous pathological sections one by one; stacking according to the registration sequence, and then processing to obtain three-dimensional model data of the nasal polyp tissue structure; and performing visual rendering on the three-dimensional model data of the nasal polyp tissue structure, and obtaining a final three-dimensional model of the nasal polyp tissue structure in combination with the preliminary three-dimensional model. According to the method, three-dimensional reconstruction and visualization are carried out on the nasal polyp tissue, the three-dimensional structure showing the distribution characteristics of inflammatory cells and tissue structures of the nasal polyp in the spatial structure can be achieved, the morphological structure content of the nasal polyp tissue can be enriched, and the visual effect of the nasal polyp tissue is improved. Meanwhile, a morphological basis is provided for further exploring the occurrence and development mechanism of chronic sinusitis with nasal polyp.

The invention belongs to the field of traditional Chinese medicines, and discloses an external medicine for treating nasal diseases, which comprises the following raw material medicines: cocklebur fruit, mint, radix angelicae, centipeda minima, asarum, magnolia flower, divaricate saposhnikovia root, agastache rugosus, houttuynia cordata and borneol. According to different dosage forms, the external medicine disclosed by the invention not only can be adhered to the nose bridge, but also can be applied in the nasal cavity during use, and is convenient to use. Especially, the nasal mucosa cannot be directly stimulated when the nasal mucosa is externally attached to the nose bridge, discomfort brought by treatment to a patient is reduced, the nasal mucosa patch is easy to accept by the patient, and treatment compliance and safety of the patient are high. The externally applied medicine disclosed by some examples has a good curative effect on various chronic rhinitis, 550 patients with various nasal diseases are treated in the clinical diagnosis and treatment process, the clinical cure rate of acute rhinitis reaches 92%, the clinical cure rate of chronic rhinitis, nasosinusitis, allergic rhinitis and postnasal drip syndrome reaches 89%, and the cure rate of infantile adenoid hypertrophy and nasal polyp reaches 93%.

The invention relates to the technical field of medical instruments, in particular to a dynamic protection system for maxillary sinus perforation in an apical surgery, which comprises an air bag, the air bag is connected with an air inflation device, a negative pressure suction device and a water leakage sensing device are arranged on the outer side of the air bag, and the air inflation device, the negative pressure suction device and the water leakage sensing device are all electrically connected with a controller. The liquid leakage condition at the perforation position is monitored in real time through the water leakage sensing device, once a leakage signal is detected, the controller immediately instructs the negative pressure suction device to start and suck away liquid and instructs the air inflation device to supplement air at the same time, the size of the air bag is finely adjusted and increased, gaps generated due to tissue changes are compensated, and it is ensured that the air bag is continuously and tightly attached to the edge of the perforation. Oral liquid and infections are fundamentally prevented from entering the maxillary sinus, the clear and dry operation view is kept, hydrostatic pressure generated by liquid accumulation is prevented from damaging the sealing performance of the air bag, and the discomfort of a patient in an operation and the occurrence probability of postoperative maxillary sinusitis are greatly reduced.

Described herein are compositions, methods, kits and devices for the treatment and / or prevention upper respiratory tract conditions, including sinusitis. In particular, bacterial populations described herein are live, purified bacteria for the modulation, restoration and / or promotion of the microbiome in the upper respiratory tract of a subject, including the nasal cavity, to promote health. Such bacterial populations may include single or multiple strains for bacteria. The multiple strains of bacteria may be strains from the same or different species, including species of Corynebacterium and / or Dolosigranulum pigrum.