Patents
Literature
Patsnap Eureka AI that helps you search prior art, draft patents, and assess FTO risks, powered by patent and scientific literature data.

487 results about "Microbiome" patented technology

A microbiome is "the ecological community of commensal, symbiotic, and pathogenic microorganisms that literally share our body space." Joshua Lederberg coined the term, arguing the importance of microorganisms inhabiting the human body in health and disease. Many scientific articles distinguish "microbiome" and "microbiota" to describe either the collective genomes of the microorganisms that reside in an environmental niche or the microorganisms themselves, respectively. However by the original definitions these terms are largely synonymous. The human body contains over 10 times more microbial cells than human cells, although the entire microbiome only weighs about 200 grams, with some weight estimates ranging as high as 3 pounds. Some regard it as a "newly discovered organ" since its existence was not generally recognized until the late 1990s and it is understood to have potentially overwhelming impact on human health. Modern techniques for sequencing DNA have enabled researchers to find the majority of these microbes, since the majority of them cannot be cultured in a lab using current techniques.

Method and system for predicting juvenile depression based on intestinal flora

The invention discloses a method and system for predicting juvenile depression based on intestinal flora, and relates to the technical field of bioinformatics and artificial intelligence, and the method comprises the steps: firstly, obtaining an original sequence of a microbiome, carrying out the preprocessing of the original sequence of the microbiome, and obtaining a feature matrix; and screening core flora characteristics with stable trans-folding by adopting characteristic importance evaluation and interpretability analysis based on a gradient boosting decision tree. A mixed weighted graph is constructed based on Spearman correlation and a proximity relationship, and an absolute value of a correlation coefficient is taken as an edge weight and an edge density is adjusted through a threshold adaptive strategy. And finally, through an improved graph attention neural network, based on edge weight attention, layer normalization and random inactivation, enhancing robustness, and adopting adaptive optimization to complete parameter learning. And determining a dynamic classification threshold according to the AUC of the target patient, and outputting a sample discrimination result and confidence. According to the method, the accuracy, stability and biological interpretability of juvenile depression recognition are remarkably improved.
Owner:SOUTHWEST JIAOTONG UNIV

Marine microorganism-derived antibacterial peptide, antibacterial composition and application

The invention belongs to the field of polypeptides, and particularly relates to an antibacterial peptide derived from marine microorganisms, an antibacterial composition and application. Based on a deep learning algorithm, five potential antibacterial peptides are mined from a global marine microbiome database, and the five antibacterial peptides are expressed in yarrowia lipolytica. Experimental tests show that the five antibacterial peptides have differentiated antibacterial effects on different bacteria, and the antibacterial peptide shown in SEQ ID NO: 3 can have an obvious inhibition effect on escherichia coli, pseudomonas aeruginosa and staphylococcus aureus, has low hemolysis and has a positive application prospect. The antibacterial peptide disclosed by the invention has the potential of further developing novel antibacterial drugs or antibacterial additives.
Owner:ZHONG KE YAO CHUANG (QING DAO) FA JIAO GONG CHENG YOU XIAN GONG SI

Salmonella infection resistant complex microbial inoculant and application thereof

The invention relates to the technical field of microorganisms, in particular to a complex microbial inoculant for resisting salmonella infection and application of the complex microbial inoculant. The invention provides a microbial composition for resisting salmonella infection. The microbial composition comprises lactobacillus reuteri, lactobacillus mucosa, lactobacillus plantarum, lactobacillus bulgaricus and pediococcus pentosaceus. Results of the embodiment of the invention show that the complex microbial inoculant provided by the invention has an excellent anti-salmonella typhimurium effect, and only the anti-salmonella typhimurium effect of the complex microbial inoculant in a specific proportion provided by the invention is optimal; meanwhile, the complex microbial inoculant can effectively relieve the harm of salmonella typhimurium to chickens, improve the growth performance of the chickens and improve the immunity of the chickens. The invention provides a new prevention and treatment thought for salmonella.
Owner:HENAN UNIV OF SCI & TECH

Directional enrichment method of soil active organic carbon, biochar-microorganism composite preparation and preparation method of biochar-microorganism composite preparation

The invention provides a directional enrichment method of soil active organic carbon, a biochar-microorganism composite preparation and a preparation method, and relates to the technical field of soil improvement and agricultural sustainable development. The method comprises the following steps: (1) screening biochar; (2) screening and culturing a functional microbiome which at least comprises carbon-decomposing bacteria, nitrogen-fixing bacteria and phosphate-solubilizing bacteria, and compounding the carbon-decomposing bacteria, the nitrogen-fixing bacteria and the phosphate-solubilizing bacteria according to a CFU ratio of (1-5): (1-3): (1-2); (3) compounding the biochar in the step (1) and the functional microbiome in the step (2) by adopting an adsorption-embedding combined process to form a biochar-microbiome synergistic regulation system; and (4) applying the charcoal-microbiome coordinated regulation system obtained in the step (3) to target soil, and culturing. According to the invention, not only is input of soil organic carbon increased, but also accurate and efficient enrichment of the soil active organic carbon library is realized.
Owner:ZHEJIANG UNIV CITY COLLEGE

Formulations for improving gut health

Various benefits to intestinal health are made by delivery of an active agent to the colon of an animal, including a human. Active ingredients include of riboflavin, vitamin A, vitamin C, vitamin D, vitamin E, vitamin K, folic acid, β-carotene, vitamin B1, niacin, vitamin B5, vitamin B6, biotin, vitamin B12, omega-3 fatty acids and combinations thereof. Benefits include increased concentration of at least one short-chain fatty acid its salt thereof in the intestine, increased microbiome diversity in the intestine, increased beneficial bacteria in the intestine, increased the butyrate synthesis pathway in the intestine, improved barrier function of the intestine, reduced redox potential of the gut, reduced amount of gas produced in the intestine; and stimulation of intestinal immune responses.
Owner:DSM IP ASSETS BV

L-DOPA microbiome therapy

The present invention generally provides methods and compositions for the treatment of Parkinson's disease and depression and / or anxiety. The invention relates to recombinant microorganisms, particularly gut-colonizing probiotics, modified to produce L-DOPA.
Owner:IOWA STATE UNIV RES FOUND INC +1

Antimicrobial compositions with low corrosivity and toxicity and the use thereof

The disclosure relates to compositions, including ready-to-use spray or wipe compositions, that are non-toxic, non-corrosive, biodegradable acidic antimicrobial compositions that exhibit broad-spectrum antimicrobial efficacy, wherein the compositions comprise an amine oxide, such as an alkyl amine oxide, in combination with an acidulant. Beneficially, the acidic antimicrobial compositions are capable of achieving at least a 3-log microbial reduction within 5 minutes under relatively mild pH conditions. The compositions provide cleaning and sanitizing.
Owner:ECOLAB USA INC

Caproic acid-producing microbial composition and application thereof

The invention belongs to the technical field of microorganisms, and particularly relates to a caproic acid-producing microbial composition and application thereof. According to the specific technical scheme, the microbial composition comprises caproic acid bacteria, clostridium and lactic acid bacteria. The caproic acid producing microbiome provided by the invention not only can be used for resourceful treatment of wastewater with high lactic acid concentration and reduction of environmental protection cost, but also can be used for construction and maintenance of pit mud, and provides a new practical reference for research of Luzhou-flavor liquor synthesis microbiome and preparation of artificial pit mud.
Owner:SICHUAN MIANZHU JIANNANCHUN DISTILLERY CO LTD +1

Composition with bacteriostatic, anti-inflammatory and / or oral cavity repairing effects and application of composition in toothpaste

The invention relates to a composition with bacteriostatic, anti-inflammatory and / or oral cavity repairing effects and application of the composition in toothpaste, and belongs to the technical field of daily chemicals. The composition disclosed by the invention is prepared from the following components in parts by weight: 0.04 to 0.06 part of pyrroloquinoline quinone and 0.2 to 0.3 part of carboxymethyl chitosan. Based on the anti-oxidative stress regulation and control capability of pyrroloquinoline quinone and the broad-spectrum antibacterial synergistic effect of carboxymethyl chitosan, pyrroloquinoline quinone and carboxymethyl chitosan are compounded and applied to a toothpaste formula system, so that the toothpaste has the effects of inhibiting bacteria, resisting inflammation, proliferating and repairing gingival fibroblasts and regulating the composition and diversity of oral microorganisms. According to the composition disclosed by the invention, through a multi-mechanism synergistic effect, an oral health maintenance system integrating bacteriostatic protection, inflammation regulation and control and mucous membrane repair is constructed, and the compound requirements of modern consumers on oral microenvironment regulation and control, mucous membrane barrier strengthening and long-term health management are accurately met.
Owner:DR KANG DAILY CHEM GRP CO LTD

Sewage treatment system based on artificial intelligence and biological targeting dynamic regulation and control

The invention discloses a sewage treatment system based on artificial intelligence and biological targeting dynamic regulation and control, and relates to the technical field of sewage treatment. By collecting inflow water quality data of sewage in real time, taking the inflow water quality data, a historical water quality fluctuation period, an environment temperature and meteorological information as input data, and combining with a pre-trained water quality prediction model, a water quality prediction model is established; obtaining water quality prediction data; matching a functional microorganism combination based on the water quality prediction data, and calculating a microorganism release amount; and the reactor execution unit releases the corresponding microorganisms through a release device based on the microorganism release amount. The problems that a traditional biological treatment system is lagging in response, low in degradation efficiency, high in operation cost and the like are solved, and the artificial intelligence and biological targeting dynamic regulation sewage treatment system is developed.
Owner:CHINESE RES ACAD OF ENVIRONMENTAL SCI

HIV (Human Immunodeficiency Virus) combined non-alcoholic fatty liver diagnosis and prediction marker and application thereof

The invention belongs to the technical field of medical diagnosis, and provides an HIV (human immunodeficiency virus) combined non-alcoholic fatty liver diagnosis and prediction marker and application. The marker comprises 39 biomarkers in total, wherein the 39 biomarkers comprise two intestinal microorganisms of enterobacter and klebsiella and 37 plasma metabolites of diacylglycerol, lysophosphatidic acid and the like; by integrating microbiome and metabonomics, the multi-dimensional marker is screened and verified, so that the problems of lack of high specificity and sensitivity, difficulty in early disease screening and incapability of effective risk assessment of an HIV (Human Immunodeficiency Virus) combined NAFLD (Non-Amplified Fragment Leukemia) early diagnosis method caused by unknown pathogenesis in the prior art are solved; the marker combination is applicable to preparation of diagnostic kits, construction of disease prediction models and development of targeted therapy drugs, and a theoretical basis is provided for early discovery, risk early warning and advanced intervention of the HIV combined with the non-alcoholic fatty liver disease.
Owner:ZHEJIANG UNIV

Colorectal cancer risk assessment system based on intestinal microbial diversity

The invention relates to the technical field of bioinformatics and medical artificial intelligence data processing, in particular to a colorectal cancer risk assessment system based on intestinal microbiological diversity, which comprises a multi-modal time sequence data acquisition module, a multi-modal time sequence data acquisition module, a target object microbiome time sequence feature data acquisition module and a target object microbiome time sequence feature data acquisition module, obtaining current medical resource load state parameters; the compliance entropy calculation module is used for resolving longitudinal compliance entropy representing the data uploading continuity willingness of the target object; the artifact interference identification module is used for generating a physiological disturbance probability value and a denoised pathological evolution feature vector; the double-constraint risk assessment module is used for calculating an initial pathological risk index of the target object; the dynamic decision scheduling module is used for determining a final dynamic intervention strategy for the target object; according to the method, the false positive and false alarm rate is remarkably reduced, and the technical pain point that real pathological evolution and environmental interference are difficult to distinguish by a traditional method is solved.
Owner:THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV

Methods and systems for generating spatial maps for agriculture sites and implementing agriculture interventions according to generated archetypes

Systems and methods for generating high-resolution spatial maps of microbiome and physicochemical indices for an agriculture site are provided. The spatial maps are generated from a limited / reduced number of physical samples acquired using a smart sampling tool provided by the systems and methods described. Insights for the agriculture site can be used to guide selection and application of interventions, according to various intervention archetypes, based upon the customized needs of the agriculture site. Performance of the agriculture site can thus be enhanced in an unprecedented, accessible, and sustainable manner.
Owner:BIOME MAKERS INC

Methods, Devices, Computer Readable Storage Media, and Electronic Devices for Obtaining Microbial Species Identity and Related Information by Sequencing

This invention relates to the area of microorganism identification, specifically involving a method of obtaining microorganism identities and related information by sequencing. The method includes: i) obtaining sequencing data, said sequencing data are obtained by amplification of microbial characteristic sequences using primers followed by sequencing the amplification products using next-generation sequencing technology; ii) comparing said sequencing data with characteristic sequence database to identify microbial composition in said samples tested; wherein perform clustering on said characteristic sequence database in advance based on the sequence similarity among reference sequences containing said characteristic sequences, obtain one or more tiers of clusters, there is at least one child seed in each cluster, and there are several seeds as reference sequences in the bottom tier cluster.
Owner:INQUIRE LIFE DIAGNOSTICS INC

Compositions and formulations based on 12-carbon atom chain structures having broad-spectrum antimicrobial activity

Novel compositions are described, each comprising at least one active constituent that has a 12-carbon atom backbone as a 12-carbon chain base structure having at least a sub-terminal nitrogen and no terminal amino group. One of the active constituents is Boc-12-Ado-OH (BOA) and / or N,N-dimethyldodecylamine N-oxide (LO). Novel particle or liposomal compositions comprising at least BOA and / or LO may be prepared with an emulsifier and / or lipid and optionally a biopolymer, and may be formulated into pharmaceutically acceptable formulations and / or medicaments with or without one or more pharmaceutically acceptable carriers or excipients for utilization as an antimicrobial against one or more microbial pathogens. The novel antimicrobial compositions have broad-spectrum growth inhibitory or other destructive activity against microbial pathogens, biofilms produced by one or more pathogens, and biofilm infections.
Owner:NATUREZA RESEARCH INC

Acquisition method and application of lactobacillus crispatus specific metabolic substrate and application of specific CAZzyme gene and PUL

The invention belongs to the technical field of bioengineering and microbiomics, and particularly relates to an acquisition method and application of a specific metabolic substrate of lactobacillus crispatus and application of a specific carbohydrate active enzyme CAZzyme gene and a polysaccharide utilization site (PUL). Genomes of lactobacillus crispatus and lactobacillus inertus are obtained from a public database, gene annotation is carried out on the genomes of the lactobacillus crispatus and the lactobacillus inertus, and a random forest model and a KEGG metabolic pathway diagram are combined to find specific CAZzyme genes, PUL and other genes with metabolic functions of the lactobacillus crispatus; a substrate which only lactobacillus crispatus can metabolize is searched based on the genome difference of the two bacteria, and the ability of the obtained substrate for promoting the growth of lactobacillus crispatus and inhibiting the growth of inert lactobacillus is evaluated through experiments. Growth and reproduction of the lactobacillus crispatus are promoted through the substrates, so that the lactobacillus crispatus accounts for a higher proportion in vagina microecology, the vagina is protected, and reproduction of other unfavorable bacteria is reduced. The assisted reproduction success rate is improved.
Owner:DALIAN MEDICAL UNIVERSITY

Method for improving saline-alkaline soil using salvia miltiorrhiza combined with biochar

A method for improving saline-alkaline soil using Salvia miltiorrhiza combined with biochar, comprising the following steps: S1. Soil preparation: applying harmless treatment organic fertilizer as a base fertilizer, evenly applying biochar according to a proportion, plowing and tilling the soil, and, according to planting density and topographical conditions, planning ridge spacing and ridge width of double high ridges; S2. Salvia miltiorrhiza planting: performing Salvia miltiorrhiza seedling transplantation using a seedling transplantation method and hole planting means, digging holes on ridge surfaces, trimming overly long parts of seedling roots, planting seedlings vertically, and covering with soil; S3. field management after transplanting: performing fertilization, weeding, and top dressing management. The present method for improving saline-alkaline soil using Salvia miltiorrhiza cultivation combined with biochar application reduces soil pH and total salt content, increases soil sucrose enzyme activity, increases soil alkaline phosphatase activity, and alters soil microbiome structure.
Owner:SHANDONG ANALYSIS AND TEST CENTER

Microbial compositions for the treatment of skin diseases

Provided herein are compositions, methods, kits, and devices for the treatment of skin diseases. Also provided herein are isolated and purified bacteria, excipients, carriers, dosage forms and routes of administration for such bacteria. Furthermore, provided herein are isolated and purified mixtures of bacteria, excipients, carriers, dosage forms and routes of administration for such mixtures. Also provided herein are conditions for treatment with bacteria and bacterial mixtures.
Owner:CONCERTO BIOSCIENCES INC

Microbial enhanced compositions comprising surfactant blends which overcome antagonistic surfactant incompatibility

Disclosed are compositions that can overcome the adverse effect that particular surfactants have on the viability, growth and biological activity of live beneficial microorganisms. The compositions include at least one anionic surfactant and at least one amphoteric surfactant or glyceryl monoesters and / or diesters, each of which, individually, adversely affect viability, growth, and / or biological activity of beneficial microorganisms, but used in combination, overcome the adverse effect that each surfactant exhibits on the beneficial microorganism. The compositions further include the beneficial microorganism, and optionally, at least one nonionic surfactant that adversely affects the viability, growth, and / or biological activity of beneficial microorganism. Also disclosed is a method for overcoming the adverse effect that particular surfactants have on beneficial microorganisms by combining selected anionic surfactants and amphoteric surfactants or glyceryl monoesters and / or diesters in particular amounts and ratios with the beneficial microorganism.
Owner:STEPAN COMPANY

Cosmetic multi-component active ingredient complex to support the skin barrier, immune balance and microbiome modulation.

Cosmetic multi-component active ingredient complex, functionally comprising at least one active ingredient from each of the following seven classes of active ingredients: • microbiome-modulating substances, • cell-protecting substances, • immunomodulating substances, • barrier-stabilizing substances, • antioxidant substances, • hydrating substances, • Soothing ingredients for sensitive skin, where the assignment of an active ingredient is made exclusively according to the primary cosmetic function defined in the description and multiple assignments are excluded.
Owner:POSTL JÖRG

Storage stable microbial composition

The present invention relates to a method for producing a stable hydrogel-cell composition comprising the steps of:a) providing a reaction mixture comprising at least one polymerizable substrate and at least one enzyme capable of polymerizing said at least one substrate, and cells, andb) incubating the mixture of step a) to form a stable hydrogel-cell composition.
Owner:LANBIOTIC GMBH

A system and method for analysing excreta

The invention provides a computer implemented method of analysing at least one excreta, comprising the steps of; - receiving a first visual information of a first excreta of a first subject; identifying at least one region of interest within the first visual information; - applying a trained machine learning model to the identified at least one region of interest in order to identify characteristics of the first excreta; and determining a microbiome profile of the first excreta based on the identified characteristics of the first excreta, wherein said characteristics comprise at least one of colour, consistency, and texture. The invention further provides a non-transitory computer readable medium and a system for analysing at least one excreta.
Owner:NV NUTRICIA

A composition for inhibiting growth of microbial contamination and a method thereof

PCT designated stageWO2025229559A1BiocideFungicidesBiotechnologyMicroorganism
A composition (100) for inhibiting growth of microbial contamination is disclosed The composition includes a plurality of volatile antimicrobial components (110) including at least one of potassium sorbate and sorbic acid. The composition further includes a plurality of non-volatile antimicrobial components (120) including natamycin. A weight ratio of the plurality of volatile antimicrobial components to the plurality of non-volatile antimicrobial components is in the range of 10:2 to 10:1. The composition is placed at a distance from a target surface to inhibit microbial growth on the target surface by releasing the plurality of volatile antimicrobial components and the plurality of non-volatile antimicrobial components into a surrounding air. The target surface is exposed to microbial contaminants. moisture and humidity.
Owner:SINGH VISHAL

A method for screening a key bacteria affecting the feed efficiency trait of poultry, probiotic bacteria and uses

The application belongs to the field of biology, and discloses a screening method for key bacteria affecting the grain-saving trait of poultry, comprising the following steps: step 1: constructing two groups of poultry with different feed utilization rates; step 2: using the feces of the high feed utilization rate group as raw material to prepare a bacterial solution, and implanting the bacterial solution into the intestinal tract of the low feed utilization rate group through fecal transplantation technology to construct a fecal transplantation group; step 3: screening first difference information and second difference information; and finding bacteria that exist simultaneously from the first difference information and the second difference information. The method of the application can quickly and accurately screen key bacteria that have a significant effect on the grain-saving trait of poultry by constructing high / low feed utilization rate groups and a fecal transplantation group, and through detection of the cecal microbiota and IgA + microbiome, and the use thereof. A key bacterium and the use thereof are also disclosed.
Owner:ANIMAL SCI RES INST GUANGDONG ACADEMY OF AGRI SCI

Microbial composition for enhancing plant growth

The present invention relates to microbial compositions, useful as biological amendments to enhance plant growth. Provided are isolated microbial strains, agricultural compositions comprising them, and their use in methods of improving plant growth and / or increasing plant yield.
Owner:CONCERT BIO LTD

Microbial composition for preventing and treating vomitoxin as well as preparation method and application of microbial composition

The invention discloses a microbial composition for preventing and treating vomitoxin as well as a preparation method and application of the microbial composition. The microbial composition for preventing and treating vomitoxin is mainly prepared by mixing a component I and a component II according to a mass ratio of (50.0-0.1): (50.0-99.9), the component I comprises trichoderma harzianum powder, trichoderma asperellum powder and penicillium bayi powder; and the component II comprises potassium phosphite, alkene potassium phosphate and potassium tripolyphosphate. The preparation method comprises the following steps: adding the component I and the component II into a stirrer, and stirring and mixing to obtain the coating. The invention also discloses an application of the microbial composition for preventing and treating vomitoxin. The microbial composition disclosed by the invention can generate metabolites with a biocontrol effect, has efficient inhibitory activity on fusarium, can reduce generation of vomitoxin, can effectively regulate diversity of soil microorganisms, realizes crop yield increase and soil improvement, and is green and environment-friendly. The method and application are simple, the cost is low, and the method is suitable for agricultural application.
Owner:CHENGDU HUAHONG ECOLOGICAL AGRI TECH CO LTD

NCP reference system, central processing unit, terminal, program, storage medium, and similar area NCP data extraction method

To provide an NCP reference system for determining an NCP to be noted, a central processing unit, a terminal, a program, a storage medium, and a similar place NCP data extraction method.SOLUTION: The program causes the central processing unit to execute a step (S1) of receiving the target microbial flora association data from the terminal, a step (S2) of extracting the target microbial flora data from the target microbial flora association data, a step (S3) of calculating a similarity between the target microbial flora data and the reference microbial flora data, a step (S4) of extracting the reference microbial flora data having a high similarity by comparing the similarity with a similarity threshold, and a step (S5) of extracting the reference area microbial data included in the reference area data to which the reference microbial flora data having the high similarity belongs, as the similar area microbial data.SELECTED DRAWING: Figure 1
Owner:SUNLIT SEEDLINGS INC

Soil pollution treatment method and system utilizing microbial remediation

The invention belongs to the technical field of pollution control, and relates to a soil pollution treatment method and system utilizing microbial remediation, and the method comprises the following steps: obtaining target remediation functional microbial agent genome and to-be-remedied site native microbiome metagenome data, and constructing a biological information basic data set; processing the data, and constructing an interaction network model containing microbial inoculum and native species nodes based on metabolic complementarity and ecological niche overlapping degree simulation calculation; analyzing the network topology structure to screen a key native co-generation node set, and generating a growth promotion demand map; determining a targeted metabolism regulation factor with targeted selectivity based on atlas reverse matching, and generating a targeted signal instruction; executing the instruction and putting a microbial agent, activating a synergistic node in situ and coupling with the microbial agent to construct a degradation function network; the method solves the problem that the colonization efficiency of the exogenous functional microbial inoculum is not high due to lack of accurate regulation and control on the native microbial community.
Owner:SHENZHEN CHUANGYINGZHE TECHNOLOGY CO LTD

Compositions and methods for modulating gut microbiomes

Provided herein are compositions and methods for modulating gut microbiomes to treat or prevent diseases. For example, provided herein are microorganisms or components thereof ( e.g., proteins involved in associating dietary fibers, such as resistant starch, with beneficial gut microorganisms) that find use treating diseases having an inflammatory component, such as Graft versus Host Disease and cancer. Prebiotic, probiotic, and synbiotic compositions are also provided. In some embodiments, the bacteria are those that naturally express pili that attach to RS granules. In other embodiments, the bacterial are engineered to express or present pili or pilus proteins (e.g., tip pilin) that attach to RS granules.
Owner:THE RGT UNIV OF MICHIGAN