77 results about "Microbiome" patented technology

Provided herein are compositions, methods, kits, and devices for the treatment of skin diseases. Also provided herein are isolated and purified bacteria, excipients, carriers, dosage forms and routes of administration for such bacteria. Furthermore, provided herein are isolated and purified mixtures of bacteria, excipients, carriers, dosage forms and routes of administration for such mixtures. Also provided herein are conditions for treatment with bacteria and bacterial mixtures.

The invention provides a computer implemented method of analysing at least one excreta, comprising the steps of; - receiving a first visual information of a first excreta of a first subject; identifying at least one region of interest within the first visual information; - applying a trained machine learning model to the identified at least one region of interest in order to identify characteristics of the first excreta; and determining a microbiome profile of the first excreta based on the identified characteristics of the first excreta, wherein said characteristics comprise at least one of colour, consistency, and texture. The invention further provides a non-transitory computer readable medium and a system for analysing at least one excreta.

This invention discloses a meglumine-luteolin complex, its preparation method, and its applications, belonging to the interdisciplinary field of microbiome and drug delivery. Using luteolin as the main material, this invention employs a dual inclusion technique with hydroxypropyl-β-cyclodextrin and meglumine to synergistically prepare a meglumine-luteolin complex with colon-targeted delivery capabilities. This invention significantly improves the delivery efficiency and drug loading of luteolin in the colon through the dual inclusion technique. The preparation process is simple, and it exhibits excellent hypoglycemic effects and colon-targeted release characteristics in the treatment of diabetes and its complications.

This invention discloses a device for preparing a special culture medium for oak based on a combination of disease-preventing and growth-promoting microorganisms. The device includes four storage hoppers, a quantitative grinding drum, a drive motor, a conical material cylinder, and a rotating mixing cone. The four storage hoppers are positioned directly above the quantitative grinding drum, and are fixedly mounted on a first support frame. The quantitative grinding drum is rotatably mounted on the first support frame, with the outlet of each storage hopper adhering to the surface of the quantitative grinding drum. The power output of the drive motor is connected to one end of the quantitative grinding drum. In this invention, the grinding bucket automatically opens when it enters the storage hopper, scooping the raw materials into the quantitative grinding drum. Simultaneously, it can cut long-fiber substrates, allowing multiple substrate materials to quantitatively enter the quantitative grinding drum. The grinding bucket closes after passing through the storage hopper, thus causing the multiple substrate materials to tumble and mix within the quantitative grinding drum.

The invention provides a method for providing skin analysis, and personalized skincare information based on that analysis, to a consumer at a retail point of sale, the method comprising: (i) at the retail point of sale, receiving a sample of the skin microbiome, which is collected from a skin surface of the consumer in a non-invasive manner, (ii) extracting the DNA from the sample of the skin microbiome and analysing the extracted DNA using a portable qPCR thermocycler which is configured to amplify and detect nucleic acids associated with a panel of microorganisms in the sample, (iii) uploading the analysis data from the thermocycler to a machine learning platform, and (iv) providing, at the retail point of sale, a profile of the consumer's skin microbiome and a personalized skincare routine for the consumer, generated from the analysis data using the machine learning platform.

The present application relates to the technical field of microorganism, and particularly relates to a microbial composition, a compound microbial agent and application.The microbial composition of the present application comprises Bacillus amyloliquefaciens, Bacillus brevis and Trichoderma harzianum, the microbial composition of the present application can simultaneously prevent and treat rice seed production process rice blast and storage process aspergillus flavus pollution, realize the whole life cycle protection of rice seed from production to storage, solve the problem that different agents need to be used to prevent and treat rice blast and aspergillus flavus pollution in the prior art.In addition, the compound microbial agent containing the microbial composition is safe, efficient, environmentally friendly, can replace chemical pesticides, reduce environmental pollution and pesticide residues, and the preparation method is simple, easy to industrial production, and has wide application prospect.

This invention discloses a set of biomarkers, reagents, kits, and applications for predicting alcoholic liver disease (ALD), belonging to the field of biomarker technology. The key technical points are: This invention uses non-target metabolomics to analyze plasma from ALD patients and healthy controls to identify potential biomarkers and related metabolic pathways in the plasma of ALD patients. Through human fecal metagenomic sequencing, potential biomarkers in the microbiome of ALD patients are identified, providing a scientific basis for the pathogenesis and early screening of ALD. Furthermore, this invention evaluates the therapeutic effect of L-threonine on ALD and explores its molecular mechanism, providing solid preclinical evidence and theoretical basis for L-threonine as a safe and effective natural metabolite-derived drug for the treatment of ALD, opening new directions for the development of innovative ALD therapies.

The present invention relates to vaginal pharmaceutical compositions and methods and uses thereof, including: treating and preventing genital inflammation in a subject; modulating the level of one or more of Lactobacillus crispatus, Lactobacillus gasseri, Lactobacillus gardneri, Lactobacillus jensenii, and Lactobacillus iners in the genital microbiome of a subject; and maintaining or improving the integrity of the cervical-vaginal epithelial barrier in a subject.

The present application belongs to the technical field of bioinformatics, and specifically relates to a chronic atrophic gastritis biomarker screening method and system based on a multi-modal differential network. The present application comprises: preprocessing metabolome data and microbiome data, respectively constructing intra-modal interaction graphs and inter-modal interaction graphs, and obtaining a multi-modal differential network by making a difference between the interaction graphs under different clinical groupings; based on the constructed differential network, a multi-level difference evaluation index is constructed: CDI is calculated at the node level to quantify the network topology and biological function differences of the biomarkers; at the structure level, a group specificity index GSI is defined to characterize the group specificity of the differential network structure; the feature ranking results obtained by CDI and GSI are fused and screened to obtain a biomarker set for atrophic gastritis classification prediction. The present application improves the effectiveness of biomarker screening under the condition of small sample and high dimension, and provides support for subsequent targeted cultivation of candidate colonies and metabolites and development of potential intervention target points.

This application provides a method and system for testing the anti-permeability and antibacterial effects of a cooktop protective film, applied in the field of material performance testing technology. The method involves constructing pre-defined microscopic damage features on the surface of the sample to simulate the initiation sites for contaminant penetration and microbial attachment. The sample is then placed in a simulated working environment, and a composite contaminant medium containing at least tracer components and microbial components is applied to the microscopic damage area. Within a pre-defined monitoring period, time-resolved monitoring of the damaged area is performed to acquire morphological evolution data, tracer component migration and diffusion data, and biofilm growth characterization data. Finally, the above data are integrated to establish a quantitative correlation model. By analyzing the dynamic interaction of various parameters, the antibacterial performance of the sample is evaluated. This method can simulate the composite aging process in a real kitchen environment and simultaneously evaluate the protective film's ability to block contaminant penetration and inhibit bacterial biofilm formation in the microscopic damage area.

Disclosed herein is are methods of preventing, reducing or inhibiting a viral or immune disorder, comprising administering to a subject at risk or that has acquired a viral or immune disorder an effective amount of a composition comprising a polypeptide derived from a reactive center loop of a serine protease inhibitor or a biologically active variant thereof, wherein the subject has not been administered antibiotics within at least one day of administering the composition. Also disclosed are compositions and kits for preventing, reducing or inhibiting a viral or immune disorder.

This invention relates to fecal microbiota transplantation (FMT) formulations for treating lung cancer, their screening methods, and applications. The invention establishes a microbiome-based quantitative screening system based on the characteristics of the lung cancer immune microenvironment, achieving a precise match between donor screening criteria and tumor-specific immune regulation needs. This overcomes the limitations of traditional FMT formulation preparations that rely on universal health standards, providing reliable support for clinical applications. Furthermore, the invention develops a combined application strategy of FMT formulations and immune checkpoint inhibitors, which can significantly improve disease control rates and prolong progression-free survival in lung cancer patients, providing an innovative solution to overcome drug resistance challenges in lung cancer immunotherapy.

The application discloses atherosclerotic cardiovascular disease patient risk assessment based on blood microorganisms, and further discloses a atherosclerotic cardiovascular disease prediction system, which comprises a sampling and layering module, a microorganism sequencing module, an index detection module and a data analysis module. The sampling and layering module divides samples into four groups, i.e., old men, old women, middle-aged men and middle-aged women, according to age / sex, and each group contains more than 100 ASCVD patients and more than 50 healthy controls. The microorganism sequencing module generates equal-length fragments by digesting DNA through BcgI enzyme digestion, connects the equal-length fragments through a linker, amplifies the equal-length fragments through PCR, and constructs a microorganism tag database (2b-Tag-DB) through Illumina sequencing. The index detection module analyzes traditional risk indexes such as blood cell classification, blood lipids and inflammatory factors. The data analysis module calculates the microorganism Gscore value, screens Gscore>5 species, and carries out diversity analysis in combination with Chao1 / Shannon index and UniFrac / MetaStorms algorithm. The prediction model module integrates the microorganism characteristics and the traditional indexes to generate a risk prediction result. The system significantly improves the ASCVD risk prediction accuracy through the collaborative analysis of the microbiome and the clinical indexes.

The present disclosure provides non-intergeneric remodeled microbes that are able to fix atmospheric nitrogen and deliver such to plants in a targeted, efficient, and environmentally sustainable manner. The utilization of the taught microbial products will enable farmers to realize more productive and predictable crop yields without the nutrient degradation, leaching, or toxic runoff associated with traditional synthetically derived nitrogen fertilizer. The remodeled microbes taught herein are able to be combined with leading agricultural chemistry and elite germplasm. Furthermore, the disclosure provides seed treatments comprising remodeled microbes.

This invention belongs to the field of multi-omics data integration technology. It discloses a system for screening multiple disease biomarkers from the gut microbiota metabolome. The system performs batch-to-batch drift correction based on the comparison values ​​of internal reference metabolites on metabolomic mass spectrometry data from multiple disease and healthy control groups. Then, it calculates the covariant stability index between metabolites and microbial species, and constructs a constrained metabolite association network by combining metabolic pathway topological distance. Based on this, the system integrates pathway constraint betweenness centrality and disease effect size to calculate network-enhanced discriminant scores, performs dimensionality reduction according to the principle of maximum coverage and minimum redundancy, and simultaneously evaluates the stability baseline values ​​of biomarker-related ecological functional modules. Finally, using ecological stability as a constraint, the system optimizes the discriminative power of multiple diseases through marginal contribution evaluation, outputting a balanced and efficient biomarker panel. This invention achieves systematic integration of microbiome and metabolome data, providing a reliable tool for the accurate diagnosis of digestive system diseases.

The present invention relates to methods for determining skin age, and particularly the severity of skin aging, including wrinkles, as well as for identifying compounds with anti-aging properties. These methods are based on measuring the Corynebacterium durum content within the skin microbiome of subjects. The inventors have demonstrated a correlation between the abundance of Corynebacterium durum in the skin microbiome and the severity of skin signs of aging.

Disclosed herein are biocontrol compositions against plant fungal pathogens and methods of use thereof for the prevention or reduction of crop loss or food spoilage. The biocontrol composition may comprise at least one microbe, or a secondary metabolite of the at least one microbe, with anti-fungal or anti-pathogenic activity. The methods and compositions disclosed herein may prevent or inhibit the growth of a variety of different pathogens, including pathogens of the genus Penicillium. The biocontrol compositions may be applied to a plant, a seed, or a produce thereof or to a packaging material used to transport or store the produce.

The application discloses Slackia a new application of sp.D-G6, and particularly relates to Slackia application of sp.D-G6 bacterial powder in pig breeding, and belongs to the field of agricultural animal breeding and microbial technology. The bacterial strain has been preserved in the Guangdong Microbial Culture Collection Center on May 8, 2019, and the preservation number is GDMCC NO: 60661. Research shows that the bacterial powder has no obvious adverse effect on pigs, has good feeding safety, can promote pig feeding and weight gain, improve average daily feed intake and average daily weight gain, and improve growth performance. Further, the bacterial powder can regulate the microbial composition of the ileum of growing pigs, increase the abundance of Firmicutes and Lactobacillus, Lactobacillus and reduce the abundance of Proteobacteria and / or Escherichia-Shigella, Escherichia-Shigella and has application prospect of being developed into a new green feed additive.

The disclosure relates to isolated microorganisms—including novel strains of the microorganisms—microbial ensembles, and compositions comprising the same. Furthermore, the disclosure teaches methods of utilizing the described microorganisms, microbial ensembles, and compositions comprising the same, in methods for modulating the production of poultry, disease resistance, and egg yield. In particular aspects, the disclosure provides methods of increasing feed efficiency, and methods of preventing colonization of pathogenic microbes.

The present invention relates to the Bacteroides eggerthii KGMB05336 strain and a use thereof, wherein, through the analysis of the microbiome in patients with non-alcoholic fatty liver disease that is caused by obesity, the Bacteroides eggerthii strain was identified as a significant strain. Oral administration of the Bacteroides eggerthii strain to animal models of obesity and non-alcoholic fatty liver disease caused by obesity resulted in body weight reduction, liver weight reduction, decrease of fat accumulation in visceral and liver tissues, and reduction in serum levels of AST (U / L), ALT (U / L), cholesterol (mg / dL), and glucose (mg / dL), thus demonstrating that the Bacteroides eggerthii strain can serve as a novel means for the prevention, improvement, or treatment of obesity and diseases caused by obesity, such as fatty liver, hepatomegaly, non-alcoholic fatty liver disease, and diabetes.

This utility model discloses a soil remediation fertilizer processing device combining humic acid and microorganisms, including a shell. A humic acid pretreatment structure communicating with the interior of the shell is provided on the upper side of the shell. The humic acid pretreatment structure includes a pretreatment chamber located on the upper side of the shell. A pulverizing chamber and a sterilization chamber are arranged vertically and vertically within the pretreatment chamber. The pulverizing chamber is circular and contains a pulverizing component for pulverizing humic acid raw materials. A filter screen is provided between the pulverizing chamber and the sterilization chamber. Multiple UVC sterilization lamps are provided in the sterilization chamber. A material pipe communicating with the interior of the shell is provided on the lower side of the sterilization chamber. A microbial component for conveying a microbial solution is also provided on the upper side of the shell. A stirring component for stirring the humic acid and microbial solution is provided inside the shell. This utility model has the advantages of improving fertilizer compounding effect and production quality through humic acid pretreatment.

The present application relates to a quality control product for quality evaluation of a preparation for intestinal flora transplantation, a preparation method and application thereof. The quality control product comprises a complex microbial component, an internal standard component, a simulated matrix and a stabilizer. The present application adopts a "multi-donor mixing" method, and compared with a scheme based on cultured strains, the quality control product prepared by the present application is highly consistent with a real FMT preparation in terms of species composition, relative proportion and bacterial activity state, and the quality control result has a strong clinical relevance. By constructing a "core bacterial spectrum", the complex flora quality control becomes simple, focused and cost controllable. In addition, the use of bifidobacterium as an internal standard has better compatibility with the sample matrix, more accurate monitoring and completely eliminates the risk of exogenous contamination.

This invention belongs to the field of new energy development technology. It discloses a control method and system for maintaining reinjection throughout the entire lifecycle of sandstone geothermal wells. The method includes: extracting continuous core samples and obtaining reservoir property data to establish a set of characteristic parameters for sandstone reservoirs; conducting reinjection condition simulation tests to obtain an optimal combination of parameters for the wellbore filtration structure; performing pumping and reinjection tests on the target geothermal well based on the optimal combination of parameters to determine initial reinjection parameters; acquiring chemical and microbial component data to determine the formation law of blockage substances under different reinjection flow rates, reinjection water temperatures, and system tightness conditions, and screening out an optimal combination of reinjection process parameters; implementing well washing operations; performing reinjection capacity retesting after well washing; comparing the retest results with the initial reinjection parameters; and dynamically adjusting the optimal combination of reinjection process parameters based on the comparison results. This significantly improves the service life of sandstone geothermal wells.

There is provided a microbial composition comprising Paenibacillus cineris and Micrococcus sp. for enhancing the inoculation rate of T. matsutake mycelium in trees, as well as a use thereof. The microbial composition according to the present invention significantly increases the inoculation rate of T. matsutake mycelium in trees. Furthermore, the composition does not inhibit the growth of T. matsutake mycelium and effectively suppresses harmful microorganisms that interfere with mycelium growth. The microbial composition of the present invention also remarkably improves the survival rate of T. matsutake-inoculated seedlings. According to the method for producing T. matsutake mycelium-inoculated seedlings of the present invention, seedlings with a high inoculation rate of T. matsutake mycelium and a high survival rate can be mass-produced and supplied in large quantities to mushroom cultivators.