29 results about "Chlorhexidine Acetate" patented technology

The application belongs to the technical field of detection, and particularly relates to a method for determining the content of chlorhexidine acetate in a disinfectant. The method for determining the content of chlorhexidine acetate in the disinfectant comprises the following steps: (1) dispersing the sample with glacial acetic acid, releasing chlorhexidine acetate combined with sample matrix components, and extracting with a methanol aqueous solution; and (2) taking a tetrabutylammonium bromide-acetic acid-acetonitrile solution as a mobile phase, and detecting with a high-performance liquid chromatograph. The method for detecting chlorhexidine acetate is simple in operation, good in reproducibility, complete in separation from impurities, high in accuracy, and has a good application prospect.

The invention belongs to the technical field of detection, and particularly relates to a method for determining the content of chlorhexidine acetate in a disinfectant. The method for determining the content of chlorhexidine acetate in the disinfectant comprises the following steps: (1) dispersing a sample by using glacial acetic acid, releasing chlorhexidine acetate combined with matrix components of the sample, and extracting by using a methanol aqueous solution; and (2) detecting by using a high performance liquid chromatograph by taking a tetrabutylammonium bromide-acetic acid-acetonitrile solution as a mobile phase. The method for detecting chlorhexidine acetate is simple and convenient to operate, good in reproducibility, complete in impurity separation and high in accuracy, and has a good application prospect.

The present disclosure is directed to a device for delivering an antimicrobial composition into a medical device. Some embodiments disclosed herein provide a method for preventing infection and microbial ingress in medical device connections. The device includes a male connector with a distal tip and a recess at the distal tip. The surface of the recess includes an antimicrobial composition. In certain implementations a male luer comprises a tapered sealing member further comprising a recess containing chlorhexidine acetate.

An analgesic, antipruritic, tissue-regenerating, wound-healing, and antibacterial ointment and its preparation method are disclosed. This invention relates to the field of traditional medicine and skin antibacterial preparations. It comprises the following components by weight: 400-600 parts sesame oil, 30-80 parts beeswax, 25-100 parts a plant-based medicinal composition, 5-25 parts an animal-based medicinal composition, 1-5 parts a mineral-based medicinal composition, and 0.1-0.3 parts an antibacterial agent. The plant-based medicinal composition includes elm branches, willow branches, purple gromwell root, and jujube branches; the animal-based medicinal composition includes dragon's blood and earthworm; the mineral-based medicinal composition is red silver pearl powder; and the antibacterial agent is chlorhexidine acetate. Using pure natural Chinese medicinal herbs as core raw materials, with a reasonable formulation and stable preparation process, it has rapid analgesic, antipruritic, hemostatic, antibacterial, tissue-regenerating, and wound-healing effects. It has significant effects on acute trauma, burns, and chronic, difficult-to-heal wounds, is safe and non-irritating, and has controllable quality.

The invention relates to the field of medicine, in particular to a sterilization composition and application thereof.The sterilization composition comprises water, chlorhexidine acetate and saussurea involucrata extract, and the mass ratio of chlorhexidine acetate to saussurea involucrata extract is 1: (10-40). The bactericidal composition has the following effects: (1) inhibiting the growth and reproduction of vaginal pathogenic bacteria; (2) relieving and anti-inflammatory effects are achieved; (3) a synergistic effect is achieved, the cost is low, and the bacteriostatic effect is good.

This utility model discloses a metering and spraying device for chlorhexidine acetate solution. The metering spraying mechanism includes a cavity located on one side of the inner wall of the housing. A first connecting rod is rotatably connected to one side of the cavity. Both ends of the outer wall of the first connecting rod are fixedly connected to rings. Two fixed seats are fixedly connected to the top of each ring. A first connecting rod is rotatably connected to one side of each of the two fixed seats. A second connecting rod is rotatably connected to the other side of the cavity. A cam is fixedly connected to the middle of the outer wall of the second connecting rod. In this utility model, when spraying chlorhexidine acetate solution, the metering cavity is first filled with chlorhexidine acetate solution. When the pressing rod is pressed, the pressure generated by the push plate will squeeze out the chlorhexidine acetate solution inside. Then, it will be re-fed through the feeding mechanism, so that the same amount of chlorhexidine acetate solution will be sprayed out each time, thereby achieving the purpose of metering and spraying, thus improving the efficiency of using chlorhexidine acetate solution.

The invention belongs to the technical field of medical supplies, and particularly relates to an implant restoration screw channel sealing material and a preparation method thereof.The preparation method comprises the following steps that S1, a polytetrafluoroethylene belt is prepared, and an expanded polytetrafluoroethylene film is obtained; s2, sodium-naphthalene complex surface modification: soaking the expanded polytetrafluoroethylene film in a sodium-naphthalene complex treatment solution to defluorinate the surface and form a carbonized layer, and then cleaning with ethanol and deionized water; s3, chitosan-chlorhexidine acetate modification: spraying a chitosan / chlorhexidine acetate stable solution on the surface of the expanded polytetrafluoroethylene film treated in S2 to form a chitosan-chlorhexidine acetate modified coating; and S4, preparing the expanded polytetrafluoroethylene film treated in S3 into a columnar solid, and performing high-temperature steam sterilization to obtain the implant restoration screw channel sealing material.

The invention relates to a traditional Chinese medicine composition for relieving or treating functional constipation, a gel ointment and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine composition is prepared from the following raw materials: radix paeoniae alba, pericarpium citri reticulatae, radix rehmanniae, angelica sinensis body, liquorice, almond, fistular onion stalk and aloe concentrated juice. The invention further provides a gel ointment containing the traditional Chinese medicine composition, the gel ointment comprises the traditional Chinese medicine composition and pharmaceutically acceptable auxiliary materials, for example, carbomer is used as a gel matrix, chlorhexidine acetate is used as a preservative, and NaOH is used as a pH regulator. The preparation method comprises the following steps: preparing the traditional Chinese medicine extract and the scallion juice; dispersing carbomer into the aloe concentrated juice to form initial gel; adding a NaOH solution to adjust the pH value to 5.5-6.5; and adding the traditional Chinese medicine extract, the preservative and the scallion juice into the gel, and uniformly mixing. The traditional Chinese medicine composition disclosed by the invention has a good bowel relaxing effect.

The present application relates to the technical field of gynecological bacteriostatic gel, and particularly relates to a ulipristal bacteriostatic gel and a preparation method thereof; the ulipristal bacteriostatic gel comprises the following components in parts by weight: chlorhexidine acetate 1-3 parts, meihua grass extract 4-8 parts, carbomer 0.8-1.2 parts, triethanolamine 0.4-0.6 parts, penetration enhancer 0.5-1.5 parts, modified nano-silver 0.04-0.07 parts, glycerol 5-8 parts, hydrogenated polyisobutylene 0.03-0.07 parts, disodium edetate 0.1-0.3 parts and purified water in a remainder amount; the chlorhexidine acetate and the meihua grass ethanol extract are compounded at a ratio of 1:(2.5-4), the flavones and polyphenols in the meihua grass can destroy the cell membrane permeability of microorganisms, promote the chlorhexidine acetate to enter the inside of the microorganism, and significantly reduce the minimum bacteriostatic concentration.

The invention provides a composite spray lotion of a targeted vaginal pathogenic bacterium biological membrane and an ultrasonic infiltration promotion system. The spray lotion comprises the following components in parts by weight: 0.1-5 parts of antibacterial peptide; 10 to 100 parts of bacteriophage; 30 to 80 parts of rose water; 10 to 30 parts of betaine; 20 to 50 parts of cocamidopropyl betaine; 5 to 20 parts of lauryl glucoside; 5 to 20 parts of sodium lauroyl sarcosinate; 0.2 to 1 part of chlorhexidine acetate; and 500 to 1000 parts of purified water. The antibacterial peptide of the spray-washing liquid directly acts on extracellular polymeric substances of vagina biomembranes, the compact structure of the extracellular polymeric substances is destroyed, and a permeation channel is opened for subsequent antibacterial components; meanwhile, pathogenic bacteria in vaginal biomembranes can be directly killed, the action mechanism of the antibacterial peptide is that bacterial cell membranes are physically damaged, and the pathogenic bacteria are not prone to generating drug resistance. The components such as the rose water can relieve discomfort such as pruritus, dryness and scorching hot caused by vaginal infection or improper cleaning, and are suitable for treatment scenes such as colpitis mycotica and abnormal leucorrhea, high in safety and wide in applicability.

The invention discloses a hydrocortisone compound ointment preparation for treating haemorrhoids, and belongs to the technical field of medicines. The technical problem to be solved is to provide a hydrocortisone compound ointment preparation which has a good hemorrhoid treatment effect and is stable. The hydrocortisone compound ointment preparation comprises the following components in percentage by weight: 0.15%-1% of corticoid, 0.025%-0.1% of a vasoconstrictor, 2%-4% of a local anesthetic, 0.1%-1.5% of L-menthol, 0.02%-0.5% of chlorhexidine acetate and 0.05%-1% of allantoin. The hydrocortisone compound ointment preparation disclosed by the invention has the medicinal effects of relieving pain and discomfort of patients suffering from haemorrhoids, promoting healing and repairing of haemorrhoids tissues, preventing infection and relieving inflammatory response, and has obvious effects of stopping bleeding and relieving swelling and pain in haemorrhoids treatment.

The invention discloses a parnassia palustris antibacterial liquid and a preparation method thereof, particularly relates to the technical field of disinfection and sterilization, and relates to the parnassia palustris antibacterial liquid and the preparation method thereof. According to the parnassia palustris antibacterial liquid, chlorhexidine acetate serves as a sterilization core, the irritation of the parnassia palustris antibacterial liquid is reduced through a hydroxypropyl-beta-cyclodextrin inclusion technology, and the parnassia palustris extract and zinc citrate are introduced to form a synergistic sterilization system; the invention discloses a parnassia palustris essence which is prepared from the following raw material components in parts by weight: 0.4 to 0.8 part of chlorhexidine acetate, 1.0 to 2.0 parts of hydroxypropyl-beta-cyclodextrin, 8 to 12 parts of propylene glycol, 0.1 to 0.3 part of zinc citrate, 0.3 to 0.7 part of parnassia palustris essential oil and 100 parts of parnassia palustris extract. Natural plant extracts and metal ions are introduced to construct a multi-target synergistic sterilization system with core components, and the components can efficiently cover and act on different life processes of microorganisms by utilizing a uniform atomized film formed by a spray formulation, so that a drug-resistant path of bacteria is effectively blocked, and the drug resistance of the bacteria is effectively inhibited. The purposes of keeping high efficiency after long-term use and not easily inducing drug resistance are achieved.

This invention discloses a long-acting antipruritic and antibacterial topical skin preparation, comprising N-ethyl-γ-L-glutamine, 1-1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphate-N-(L-γ-glutamyl-N-ethyl)-ethanolamine (POPE-N-Et-Gln-α), chlorhexidine acetate, and saffron extract as active ingredients, formulated into a hydrogel or cream with a pharmaceutically acceptable matrix. POPE-N-Et-Gln-α provides rapid transdermal action, while N-ethyl-γ-L-glutamine offers sustained-release and long-lasting effects; saffron extract provides anti-inflammatory and antioxidant effects, and chlorhexidine acetate provides antibacterial and antifungal effects. This invention is hormone-free and non-addictive, achieving both rapid and long-lasting antipruritic effects, and is suitable for eczema, urticaria, dry skin, neurodermatitis, psoriasis, microbial infections, and skin itching caused by insect bites.

The invention discloses a composition of a medical catheter lubricating hydrophilic coating and a preparation method of the composition, belongs to the technical field of medical materials, and aims to solve the problems of excessive swelling, poor combination stability, short service time, low cost and the like caused by uniform water absorption of a coating formed by curing a medical catheter hydrophilic lubricating coating composition in the prior art. In order to overcome the defects that an existing improvement scheme depends on a complex process, is high in cost and is easy to layer, the invention relates to the technical field of medical instruments, and comprises the following components in percentage by mass: 7-10% of polyvinylpyrrolidone; 1.5 to 2.5 percent of polyethylene glycol diacrylate; 0.8 to 1.2 percent of a silane coupling agent KH-570; the content of the medical grade 2-hydroxy-4-methoxyacetophenone is 0.1 to 0.2 percent; 62-68% of absolute ethyl alcohol; 14 to 18% of deionized water; 0.1 to 0.3 percent of chlorhexidine acetate; and 0.2 to 0.5 percent of citric acid. The composition has the property of spontaneously forming a gradient cross-linked structure, the gradient water absorption characteristic can be achieved under the conditions of conventional coating and single-condition curing, extra precise process control is not needed, the industrialization difficulty and cost are reduced, and meanwhile the problem that the binding force between multiple coatings is poor is solved.

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a pharmaceutical composition containing a high-molecular complex for external use on skin and a preparation method of the pharmaceutical composition, and the pharmaceutical composition comprises the following components in percentage by weight: 0.1-0.3% of sodium humate; 0.8 to 1.4% of a bacteriostatic composition; 0.8 to 1.4% of a soothing composition; 0.12 to 0.14 percent of chlorhexidine acetate; 6-20% of a humectant; 1-3% of an emulsifier; 0.1%-0.5% of a functional auxiliary material; the balance of pure water; the antibacterial composition comprises a glabrous sarcandra herb extract, a radix sophorae flavescentis extract and a fructus cnidii extract; the soothing composition comprises an earthworm extract and a fructus kochiae extract. The sodium humate is compounded with other components, so that the inhibition effect of the composition on microorganisms such as candida albicans, staphylococcus aureus and escherichia coli can be improved. Meanwhile, the sodium humate can effectively repair and relieve skin mucosa, so that the skin is quickly recovered to a healthy state.

The invention discloses an aloe barbadensis leaf water composition for removing acnes and application thereof, and the composition is prepared from the following components in percentage by mass: 91 to 97 percent of aloe barbadensis leaf water, 1 to 4 percent of nicotinamide, 1 to 4 percent of arbutin, 0.1 to 0.4 percent of benzalkonium bromide and 0.1 to 0.6 percent of chlorhexidine acetate. The invention also provides a preparation method and application of the composition. The method comprises the following steps: weighing the raw materials in proportion, then mixing the aloe barbadensis leaf water, nicotinamide, arbutin, benzalkonium bromide and chlorhexidine acetate in a container, stirring and dissolving uniformly, sampling and detecting to be qualified, disinfecting and sterilizing, and finally, sealing, packaging and storing the aloe barbadensis leaf water, the nicotinamide, the arbutin, the benzalkonium bromide and the chlorhexidine acetate. The composition is used for preparing skin care products for removing acnes. The aloe barbadensis leaf water composition for removing acnes, prepared by the preparation method disclosed by the invention, adopts acnes-removing components derived from the nature, is safe in acnes removal without hurting the skin, restores the skin to a healthy state while repairing the damaged skin, and inhibits the re-breeding of acnes and bacteria.

The invention provides a novel wound surface protection film coating agent as well as a preparation method and application thereof, and belongs to the technical field of trauma healing. The film coating agent provided by the invention is prepared from the following raw materials: polyacrylic resin, an ethyl acrylate-methyl methacrylate copolymer, povidone, dragon's blood and the like. The preparation method of the film coating agent comprises the following steps: adding chlorhexidine acetate, povidone, triethyl citrate and the like into 95% ethanol under low-speed stirring; adding polyacrylic resin, uniformly stirring, and swelling; adding the ethyl acrylate-methyl methacrylate copolymer, the antibacterial agent and the dragon's blood, and continuously stirring and uniformly mixing to obtain the film coating agent. The wound surface protection film coating agent is fast in film forming, can form a film within 1 min, is good in film integrity, can effectively absorb wound exudate, is good in antibacterial ability, can effectively prevent scar hyperplasia, and has a good treatment effect on wound surfaces such as scratches, stabbing wounds, scratches and scalds.

The invention belongs to the technical field of preparation of antibacterial preparations, and particularly relates to an antibacterial composition, an antibacterial nano-emulsion, an antibacterial preparation and application of the antibacterial composition, the antibacterial nano-emulsion and the antibacterial preparation. Through verification, the benzalkonium bromide and the chlorhexidine acetate can achieve the effect of synergistically resisting methicillin-resistant staphylococcus aureus (MRSA) by inhibiting or removing a biological membrane (cell membrane), and particularly, the nano-emulsion prepared from the benzalkonium bromide and the chlorhexidine acetate has an excellent MRSA resisting effect; the minimum inhibitory concentration (MIC) of the prepared nanoemulsion on MRSA bacteria is 1.5625 [mu] g / mL, and the minimum bactericidal concentration (MBC) of the prepared nanoemulsion on MRSA bacteria is 6.25 [mu] g / mL; in addition, the prepared nanoemulsion is low in toxicity and excellent in stability. Moreover, the antibacterial preparation disclosed by the invention is simple in preparation process, stable in quality and suitable for large-scale production, can be widely applied to infection of multiple drug-resistant bacteria of skin wounds, and has a good market application prospect.

The invention relates to immunoregulation hydrogel with antibacterial and antioxidant characteristics and a preparation method of the immunoregulation hydrogel. The immunoregulation hydrogel is prepared from nanoparticles self-assembled by procyanidine and chlorhexidine acetate, methacrylated gelatin and a porcine acellular dermal matrix. The hydrogel disclosed by the invention has good biocompatibility, self-healing capability and mechanical property, has excellent antibacterial and antioxidant properties, can effectively regulate immunity and promote wound healing, shows remarkable effects in all aspects, and has a good application prospect.

The application discloses a preparation method and application of a compound preparation containing triamcinolone acetonide. The compound preparation containing triamcinolone acetonide comprises the following raw materials in percentage by weight: triamcinolone acetonide acetate 0.06%-0.2%, heparin sodium 0.002%-0.004%, allantoin 0.4%-0.6%, chlorhexidine acetate 0.015%-0.025% and a pH regulator; wherein the pH regulator adjusts the pH of the compound preparation containing triamcinolone acetonide to 6-7. The application provides preparation of an external preparation of triamcinolone acetonide with a higher specification, and the drug amount penetrating into the skin is more in the same time, and the existing product is faster in effect. In the preparation formula, the stability of the preparation is ensured by controlling the pH value of the preparation, the problem of oil-water stratification is avoided, and the stability of the preparation is improved.

The invention discloses tea tree oil bacteriostatic cream and a preparation method thereof. The tea tree oil bacteriostatic cream is prepared from the following raw materials in parts by weight: 80 parts of vaseline, 4 parts of wool fat, 3 parts of tea tree oil, 2 parts of borneol, 2 parts of menthol, 2 parts of vitamin E, 0.3 part of chlorhexidine acetate, 15 parts of centipede, 45 parts of scorpio and 6.7 parts of 75% ethanol. The antibacterial paste has the advantage of good antibacterial effect, and solves the problems that in the preparation process of existing antibacterial paste, natural antibacterial components and chemical antibacterial components are inconvenient to combine, the natural antibacterial components and the chemical antibacterial components have different action mechanisms, and if the natural antibacterial components and the chemical antibacterial components cannot be well combined for use, the antibacterial effect is poor. The advantages of the two can not be fully utilized to cover a wider antibacterial spectrum, so that the overall antibacterial effect of the product is influenced.

1. Name of the product in this design: Packaging Box (Compound Chlorhexidine Acetate Antibacterial Solution). 2. Purpose of this design: For product packaging. 3. The key design elements of this product are the combination of shape, pattern, and color. 4. The image or photograph that best illustrates the design's key points: a 3D model. 5. The design for which protection is sought includes color.

The invention discloses an oral gargle as well as a preparation method and application thereof, relates to the technical field of oral care, and solves the problem that an existing product is difficult to safely and effectively relieve a dry mouth symptom for a long time. Comprising a moisturizing film-forming agent, an antibacterial disinfectant, an anti-allergy soothing agent and a flavoring agent, the moisturizing film-forming agent is polyethylene glycol active ester. The antibacterial disinfectant is selected from chlorhexidine, chlorhexidine acetate, benzalkonium chloride and polyhexamethylene biguanidine; the anti-allergy soothing agent is selected from allantoin, tocopherol acetate, tranexamic acid, dipotassium glycyrrhizinate, a calendula extract, a chamomile extract, matricaria recutita / eucalyptus globulus leaf oil, a tea leaf extract, a propolis extract and the like; the flavoring agent is selected from peppermint essence, xylitol, sucralose, saccharin sodium salt and sodium citrate. The mouthwash can be used as a product for preventing or treating xerostomia or oral mucositis, and the mouthwash is packaged in a powder form and forms a product unit together with an auxiliary bottle for dissolving the powder.

The invention relates to a rapid self-condensing hydrogel dressing applied to wound repair and a preparation method of the rapid self-condensing hydrogel dressing. The dressing is prepared from phenylboronic acid grafted oxidized dextran POD, carbonyl dihydrazine modified gelatin Gel-CDH and nanoparticles PAC NPs self-assembled by procyanidine and chlorhexidine acetate. When the dressing disclosed by the invention is in contact with wound exudate, the dressing can be quickly self-crosslinked to form stable hydrogel, and has excellent tissue adhesiveness, self-healing capability and mechanical properties similar to skin. Besides, the hydrogel has broad-spectrum antibacterial activity, strong ROS (reactive oxygen species) removal capacity and high biocompatibility, can promote macrophages to be polarized to M2 phenotype, down-regulate proinflammatory cytokines and enhance anti-inflammatory markers, and has a good market application prospect.

The invention relates to the technical field of disinfectants, and particularly discloses a skin mucosa disinfectant and a preparation process thereof. The skin mucosa disinfectant is prepared from the following raw materials in percentage by weight: 3%-6% of povidone iodine, 0.02%-0.1% of monopotassium phosphate, 0.2%-0.4% of dipotassium phosphate, 0.02%-0.06% of chlorhexidine acetate, 1%-3% of a surfactant, 2%-4% of polyvinylpyrrolidone and the balance of purified water. According to the skin mucosa disinfectant disclosed by the invention, povidone iodine and chlorhexidine acetate are taken as effective bactericidal components, and loss of effective iodine content in a povidone iodine solution system is effectively reduced through dipotassium phosphate and monopotassium phosphate; the povidone-iodine solution system has good stability and durability in the storage process, so that the disinfectant can have good disinfection and sterilization effects when acting on an affected part.

The invention belongs to the field of biological medicine, and provides a selective bacteriostatic agent for resisting vaginal infection and application thereof. The selective bacteriostatic agent comprises at least one of triclosan (12.5 to 300 [mu] g / mL), parachlorometaxylenol (100 to 200 [mu] g / mL), chlorhexidine acetate (25 [mu] g / mL) and chlorhexidine gluconate (50 [mu] g / mL); the inhibiting effect of the selective bacteriostatic agent on harmful bacteria in the vagina is obviously higher than that of the selective bacteriostatic agent on probiotics. The invention also discloses an application of the selective bacteriostatic agent in preparing a medicine for treating vaginitis, and a preparation for resisting vaginal infection, which comprises the selective bacteriostatic agent. The four bacteriostatic agents disclosed by the invention can effectively inhibit the growth of harmful bacteria in the vagina in respective concentration and pH ranges, have weak inhibitory effect on probiotics in the vagina, have remarkable selective bacteriostatic activity, and can be effectively used for vagina cleaning and disinfection and prevention and treatment of infection.

The invention discloses antibacterial liquid with functions of tightening and repairing vaginal mucosa tissues and a production process thereof. The antibacterial liquid is prepared from the following components in parts by weight: 20-30 parts of sandalwood oil, 20-30 parts of grape seed oil, 20-30 parts of sea buckthorn seed oil, 5-10 parts of polygala tenuifolia, 5-10 parts of semen cuscutae, 5-10 parts of fructus evodiae, 1-5 parts of Chinese prickly ash, 0.1-0.3 part of chlorhexidine acetate and 0.5-1.5 parts of a stabilizer, wherein the stabilizer comprises tert-butyl hydroxy anisd and caprylyl glycol; the antibacterial liquid prepared from the raw materials has good stability, and can maintain effective antibacterial ability in a severe environment and a long-term storage scene.

The invention discloses a chlorhexidine acetate lotion and a preparation method and application thereof.The chlorhexidine acetate lotion is prepared from, by weight, 4.6 parts to 5.4 parts of rhizoma coptidis, 6.8 parts to 8.2 parts of cortex phellodendri, 6.8 parts to 8.2 parts of radix et rhizoma rhei, 1.12 parts to 1.4 parts of aloe, 1.12 parts to 1.4 parts of radix sophorae flavescentis, 2.2 parts to 2.8 parts of radix sanguisorbae, 0.44 part to 0.56 part of chlorhexidine acetate, 0.8 part to 1.0 part of glacial acetic acid solution, 4.5 parts to 5.5 parts of Tween 80 and the balance purified water. The chlorhexidine acetate lotion is remarkable in antibacterial effect, small in irritation and high in stability, can promote wound healing, has important application value in preparation of related antibacterial drugs and skin ulcer nursing drugs, meets clinical use requirements, and is wide in application scene and high in market value.

To provide a solid cleaning preparation.SOLUTION: A solid cleaning preparation for cleaning an intraoral appliance such as a denture or an orthodontic retainer, the solid cleaning preparation containing (A) at least one selected from the group consisting of a dichloroisocyanurate salt, a quaternary ammonium salt, isopropylmethylphenol, a fluoride, thymol, hinokitiol, cetylpyridinium chloride, benzethonium chloride, chlorhexidine acetate, chlorhexidine gluconate, sodium monofluorophosphate, triclosan, lysozyme chloride, and chlorhexidine hydrochloride, (B) an oxygen-based bleaching agent, (C) a foaming agent, and (D) at least one selected from the group consisting of calcium silicate, dextrin, lactose, starch, gum arabic, gelatin, casein, and talc, wherein an amount of the component (D) is 0.2 pt.mass or more and 5 pts.mass or less with respect to 1 pt.mass of the component (A).SELECTED DRAWING: None