52 results about "Chlorhexidine Acetate" patented technology

The invention discloses a female private part composite bacteriostatic agent and a preparation method thereof, and relates to the technical field of female care products. The female private part compound bacteriostatic agent is prepared from the following raw materials in percentage by weight: 0.2 to 0.5 percent of cortex phellodendri extract, 0.2 to 0.5 percent of radix sophorae flavescentis extract, 0.05 to 0.1 percent of tanshinone extract, 0.05 to 0.1 percent of fructus cnidii extract, 0.5 to 1.2 percent of cranberry extract, 0.02 to 0.04 percent of chlorhexidine gluconate, 0.02 to 0.04 percent of chlorhexidine acetate, 0.08 to 0.2 percent of glycerol monolaurate, 0.3 to 0.9 percent of lactic acid, 0.3 to 0.9 percent of probiotic microcapsules, 1 to 2 percent of compound amino acid surfactant, 0.1 to 0.5 percent of vitamin E and the balance of water. 0.1-0.3% of a preservative, 2-4% of glycerol and the balance of water. The antibacterial health-care product has an excellent antibacterial effect, and can effectively regulate the micro-ecological balance of the private parts of women.

The invention discloses a cassia seed antibacterial liquid for eyes and a preparation method thereof. The semen cassiae antibacterial liquid for the eyes is prepared from the following components in percentage by mass: 2.0 to 3.0 percent of semen cassiae extract, 2.0 to 3.0 percent of magnolia flower leaf extract, 2.0 to 3.0 percent of flos chrysanthemi indici extract, 2.0 to 3.0 percent of radix gentianae extract, 2.0 to 3.0 percent of flos eriocauli extract, 1.0 to 2.0 percent of radix ginseng extract, 2.0 to 3.0 percent of rhizoma polygonati extract, 1.0 to 2.0 percent of radix codonopsis extract and the balance of water. The traditional Chinese medicine composition has the beneficial effects that various eyesight-improving traditional Chinese medicine components are adopted, the traditional Chinese medicine composition does not contain any artificial hormone and antibiotic, has no toxic or side effect, has the effects of clearing liver and improving eyesight, resisting bacteria and inflammation, and improving retina microcirculation and blood flow volume, and is matched with chlorhexidine acetate, so that the traditional Chinese medicine composition has the effects of clearing liver and improving eyesight, resisting bacteria and inflammation, and improving retina microcirculation and blood flow volume. The eye drops have the advantages that the eye drops have strong inhibition effects on candida albicans, escherichia coli and staphylococcus aureus, the components of the eye drops do not contain any irritant component, irritation influence on eyes is avoided, the preparation method is simple, and the eye drops can be easily applied to large-scale production and processing processes.

The present invention belongs to the technical field of contact lens preparation, and discloses an antibacterial coating for contact lenses and a contact lens with an antibacterial coating and a preparation method thereof. The antibacterial coating of the present invention comprises the following components by mass: 2 to 4 parts of hydroxypropyltrimethylammonium chloride chitosan nanoparticles, 5 to 8 parts of chlorhexidine acetate, 2 to 4 parts of asiaticoside, 10 to 15 parts of hyaluronic acid, 2 to 6 parts of γ-polyglutamic acid, 10 to 15 parts of polyvinyl alcohol and 1 to 5 parts of a buffer. The antibacterial coating for contact lenses of the present invention has excellent antibacterial properties, and can significantly reduce the number of fungi on the surface of the contact lens coated with the antibacterial coating; the angular contact angle of the antibacterial coating for contact lenses can be as low as 50°, so that the contact lenses coated with the antibacterial coating of the present invention have excellent moisturizing properties, thereby improving the comfort of the contact lenses when worn.

The invention provides a composition with vaginal bacteriostasis, the composition comprises chlorhexidine acetate, a Chinese herbal medicine preparation, lactic acid and a lactobacillus fermentation product, the Chinese herbal medicine preparation comprises cortex phellodendri, fructus cnidii, radix sophorae flavescentis and radix stemonae, and the pH value of the composition is 3.8-4.5. The invention also provides a lotion containing the composition and having a vaginal bacteriostasis effect and a preparation method of the lotion, besides the traditional bacteriostasis component chlorhexidine acetate, the traditional Chinese medicine bacteriostasis component, lactic acid and a lactobacillus fermentation product are also added, and all the components have a synergistic effect on vaginal bacteriostasis after being combined, so that the composition has a good effect on vaginal bacteriostasis. The pH value of the lotion is adjusted to 3.8-4.5 by the added lactic acid, so that the normal acidity of the vaginal cavity is not damaged, the growth of vaginal bacillus is facilitated, the lotion does not contain sugar substances such as chitosan and glucose, the growth and reproduction of pathogenic bacteria and trichomonas vaginalis are not facilitated, and the lotion has a special antibacterial function while the biological characteristics of the vaginal cavity are maintained.

The application belongs to the technical field of detection, and particularly relates to a method for determining the content of chlorhexidine acetate in a disinfectant. The method for determining the content of chlorhexidine acetate in the disinfectant comprises the following steps: (1) dispersing the sample with glacial acetic acid, releasing chlorhexidine acetate combined with sample matrix components, and extracting with a methanol aqueous solution; and (2) taking a tetrabutylammonium bromide-acetic acid-acetonitrile solution as a mobile phase, and detecting with a high-performance liquid chromatograph. The method for detecting chlorhexidine acetate is simple in operation, good in reproducibility, complete in separation from impurities, high in accuracy, and has a good application prospect.

The invention belongs to the technical field of detection, and particularly relates to a method for determining the content of chlorhexidine acetate in a disinfectant. The method for determining the content of chlorhexidine acetate in the disinfectant comprises the following steps: (1) dispersing a sample by using glacial acetic acid, releasing chlorhexidine acetate combined with matrix components of the sample, and extracting by using a methanol aqueous solution; and (2) detecting by using a high performance liquid chromatograph by taking a tetrabutylammonium bromide-acetic acid-acetonitrile solution as a mobile phase. The method for detecting chlorhexidine acetate is simple and convenient to operate, good in reproducibility, complete in impurity separation and high in accuracy, and has a good application prospect.

The present disclosure is directed to a device for delivering an antimicrobial composition into a medical device. Some embodiments disclosed herein provide a method for preventing infection and microbial ingress in medical device connections. The device includes a male connector with a distal tip and a recess at the distal tip. The surface of the recess includes an antimicrobial composition. In certain implementations a male luer comprises a tapered sealing member further comprising a recess containing chlorhexidine acetate.

An analgesic, antipruritic, tissue-regenerating, wound-healing, and antibacterial ointment and its preparation method are disclosed. This invention relates to the field of traditional medicine and skin antibacterial preparations. It comprises the following components by weight: 400-600 parts sesame oil, 30-80 parts beeswax, 25-100 parts a plant-based medicinal composition, 5-25 parts an animal-based medicinal composition, 1-5 parts a mineral-based medicinal composition, and 0.1-0.3 parts an antibacterial agent. The plant-based medicinal composition includes elm branches, willow branches, purple gromwell root, and jujube branches; the animal-based medicinal composition includes dragon's blood and earthworm; the mineral-based medicinal composition is red silver pearl powder; and the antibacterial agent is chlorhexidine acetate. Using pure natural Chinese medicinal herbs as core raw materials, with a reasonable formulation and stable preparation process, it has rapid analgesic, antipruritic, hemostatic, antibacterial, tissue-regenerating, and wound-healing effects. It has significant effects on acute trauma, burns, and chronic, difficult-to-heal wounds, is safe and non-irritating, and has controllable quality.

The invention relates to the technical field of medicines, in particular to skin antibacterial transdermal liquid and a preparation method thereof. The traditional Chinese medicine composition is prepared by mixing the following raw materials in percentage by weight: 0.1%-0.4% of radix euphorbiae lantu, 0.25%-0.75% of rhizoma smilacis glabrae, 0.15%-0.55% of honeysuckle flower, 0.08%-0.38% of radix salviae miltiorrhizae, 0.2%-0.8% of flos chrysanthemi indici, 0.05%-0.55% of spina gleditsiae, 0.05%-0.45% of typhonium giganteum, 3%-8% of borneol, 0.25%-0.6% of radix sophorae flavescentis, 0.2%-0.65% of fructus cnidii, 0.15%-0.45% of fructus kochiae, 0.01%-0.45% of radix stemonae and 0.02%-0.55% of chlorhexidine acetate. The skin antibacterial transdermal liquid has the beneficial effects that through the synergistic interaction of various natural traditional Chinese medicine components and the combination of a modern extraction process, effective components are fully reserved, the skin antibacterial transdermal liquid has a remarkable inhibition effect on various skin pathogenic bacteria such as staphylococcus aureus, escherichia coli and candida albicans, and the antibacterial rate can reach 90% or above; meanwhile, the traditional Chinese medicine is used for improving skin microcirculation, and penetration promoting components such as borneol are used, so that the medicine can quickly penetrate through the skin cuticle and penetrate into the skin tissue to exert the medicine effect, the symptoms such as skin itch and inflammation are effectively relieved, the preparation process is relatively simple, and industrial production is easy.

The invention discloses a component traditional Chinese medicine preparation for treating moderate and severe uterine prolapse, which is prepared from the following components in percentage by mass: 2.5 to 3.5 percent of rhizoma bletillae gum, 1.0 to 2.0 percent of centella asiatica total glycosides, 0.3 to 0.6 percent of fructus cnidii oil, 0.2 to 0.5 percent of cinnamon oil, 0.001 to 0.005 percent of NP-700 type sodium polyacrylate, 0.35 to 0.65 percent of B type carbomer, 4.5 to 7.5 percent of glycerol, 0.35 to 0.65 percent of triethanolamine, 0.05 to 0.09 percent of chlorhexidine acetate and the balance of purified water. The sum of the mass percentages of the components is 100%. The specific preparation method comprises the following steps: weighing the components, dissolving, mixing, adjusting the pH value, and forming. The traditional Chinese medicine preparation is used for preparing medicines for treating moderate and severe uterine prolapse, has the effects of warming yang and promoting tissue regeneration, and can repair degenerated and damaged pelvic floor muscle groups by promoting collagen expression, extracellular matrix generation and muscle cell proliferation in pelvic floor tissues after vaginal administration; the structural strength and supporting tension of pelvic floor tissue are improved, the supporting and lifting effect on the uterus is recovered, and the prolapsed uterus is stably reset.

The invention relates to the technical field of antibacterial products, in particular to skin antibacterial liquid. The skin antibacterial liquid is prepared from the following raw materials in parts by mass: akebiaquinata, cortex dictamni, tribulus terrestris, radix sophorae flavescentis, slough, chlorhexidine acetate, sodium benzoate and purified water. The skin antibacterial liquid is a Chinese herbal medicine preparation, does not contain hormones, has the effects of clearing away heat and toxic materials, removing dampness and relieving itching, sterilizing and treating tinea and promoting wound healing, is high in permeability, can eliminate deep skin inflammation, can cure various difficult and miscellaneous diseases of skin, and relieves pains of patients with skin diseases. The ointment has an inhibiting effect on staphylococcus aureus, escherichia coli and candida albicans, and is suitable for acute, subacute and chronic eczema, specific dermatitis, contact dermatitis, insect biting and crawling dermatitis, paronychia, hormone drug sequelae, pompholyx, sweat stain, miliaria, sunburn, burn, frostbite, wound infection, scabies, tinea capitis, tinea pedis, tinea manuum, tinea cruris, tinea corporis and the like.

The invention relates to the field of medicine, in particular to a sterilization composition and application thereof.The sterilization composition comprises water, chlorhexidine acetate and saussurea involucrata extract, and the mass ratio of chlorhexidine acetate to saussurea involucrata extract is 1: (10-40). The bactericidal composition has the following effects: (1) inhibiting the growth and reproduction of vaginal pathogenic bacteria; (2) relieving and anti-inflammatory effects are achieved; (3) a synergistic effect is achieved, the cost is low, and the bacteriostatic effect is good.

This utility model discloses a metering and spraying device for chlorhexidine acetate solution. The metering spraying mechanism includes a cavity located on one side of the inner wall of the housing. A first connecting rod is rotatably connected to one side of the cavity. Both ends of the outer wall of the first connecting rod are fixedly connected to rings. Two fixed seats are fixedly connected to the top of each ring. A first connecting rod is rotatably connected to one side of each of the two fixed seats. A second connecting rod is rotatably connected to the other side of the cavity. A cam is fixedly connected to the middle of the outer wall of the second connecting rod. In this utility model, when spraying chlorhexidine acetate solution, the metering cavity is first filled with chlorhexidine acetate solution. When the pressing rod is pressed, the pressure generated by the push plate will squeeze out the chlorhexidine acetate solution inside. Then, it will be re-fed through the feeding mechanism, so that the same amount of chlorhexidine acetate solution will be sprayed out each time, thereby achieving the purpose of metering and spraying, thus improving the efficiency of using chlorhexidine acetate solution.

The invention belongs to the technical field of medical supplies, and particularly relates to an implant restoration screw channel sealing material and a preparation method thereof.The preparation method comprises the following steps that S1, a polytetrafluoroethylene belt is prepared, and an expanded polytetrafluoroethylene film is obtained; s2, sodium-naphthalene complex surface modification: soaking the expanded polytetrafluoroethylene film in a sodium-naphthalene complex treatment solution to defluorinate the surface and form a carbonized layer, and then cleaning with ethanol and deionized water; s3, chitosan-chlorhexidine acetate modification: spraying a chitosan / chlorhexidine acetate stable solution on the surface of the expanded polytetrafluoroethylene film treated in S2 to form a chitosan-chlorhexidine acetate modified coating; and S4, preparing the expanded polytetrafluoroethylene film treated in S3 into a columnar solid, and performing high-temperature steam sterilization to obtain the implant restoration screw channel sealing material.

The present invention relates to a solid composition in the form of powder or granulate comprising a salt of chlorhexidine selected from chlorhexidine digluconate and chlorhexidine diacetate or a mixture thereof, and cetylpyridinium chloride for use in the prevention and / or treatment of oral infectious pathologies.

The invention relates to a traditional Chinese medicine composition for relieving or treating functional constipation, a gel ointment and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine composition is prepared from the following raw materials: radix paeoniae alba, pericarpium citri reticulatae, radix rehmanniae, angelica sinensis body, liquorice, almond, fistular onion stalk and aloe concentrated juice. The invention further provides a gel ointment containing the traditional Chinese medicine composition, the gel ointment comprises the traditional Chinese medicine composition and pharmaceutically acceptable auxiliary materials, for example, carbomer is used as a gel matrix, chlorhexidine acetate is used as a preservative, and NaOH is used as a pH regulator. The preparation method comprises the following steps: preparing the traditional Chinese medicine extract and the scallion juice; dispersing carbomer into the aloe concentrated juice to form initial gel; adding a NaOH solution to adjust the pH value to 5.5-6.5; and adding the traditional Chinese medicine extract, the preservative and the scallion juice into the gel, and uniformly mixing. The traditional Chinese medicine composition disclosed by the invention has a good bowel relaxing effect.

The invention provides compound antibacterial powder for inhibiting gynecological infection and a preparation method, and relates to the technical field of gynecological infection disease treatment, the compound antibacterial powder comprises 15%-25% of pomegranate flower extract, 15%-25% of pomegranate peel extract, 10%-20% of nutgall extract, 10%-20% of rose extract, 5%-10% of chlorhexidine acetate, 2%-5% of chitosan, 18%-45% of starch, and 0.5%-1% of microcrystalline cellulose. According to the compound antibacterial powder for inhibiting gynecological infection, the traditional Uygur medicine materials and the modern compound PCSB-1 are adopted, so that the antibacterial powder formula with multiple effects in one dose is realized. In the components, pomegranate flower, pomegranate peel and nutgall extract synergistically destroy pathogenic biomembranes and provide powerful antibacterial, antifungal and antiamebic activity, rose extract has the effects of soothing liver-qi stagnation, promoting blood circulation and repairing mucous membranes, and medicine-grade chlorhexidine acetate and chitosan are added, so that the bacterium loading capacity can be rapidly reduced, a protective film is formed on the vaginal mucous membranes, and the effects of preventing and treating the vaginal mucous membranes are achieved. The drug effect retention time is prolonged.

The present application relates to the technical field of gynecological bacteriostatic gel, and particularly relates to a ulipristal bacteriostatic gel and a preparation method thereof; the ulipristal bacteriostatic gel comprises the following components in parts by weight: chlorhexidine acetate 1-3 parts, meihua grass extract 4-8 parts, carbomer 0.8-1.2 parts, triethanolamine 0.4-0.6 parts, penetration enhancer 0.5-1.5 parts, modified nano-silver 0.04-0.07 parts, glycerol 5-8 parts, hydrogenated polyisobutylene 0.03-0.07 parts, disodium edetate 0.1-0.3 parts and purified water in a remainder amount; the chlorhexidine acetate and the meihua grass ethanol extract are compounded at a ratio of 1:(2.5-4), the flavones and polyphenols in the meihua grass can destroy the cell membrane permeability of microorganisms, promote the chlorhexidine acetate to enter the inside of the microorganism, and significantly reduce the minimum bacteriostatic concentration.

The invention provides a composite spray lotion of a targeted vaginal pathogenic bacterium biological membrane and an ultrasonic infiltration promotion system. The spray lotion comprises the following components in parts by weight: 0.1-5 parts of antibacterial peptide; 10 to 100 parts of bacteriophage; 30 to 80 parts of rose water; 10 to 30 parts of betaine; 20 to 50 parts of cocamidopropyl betaine; 5 to 20 parts of lauryl glucoside; 5 to 20 parts of sodium lauroyl sarcosinate; 0.2 to 1 part of chlorhexidine acetate; and 500 to 1000 parts of purified water. The antibacterial peptide of the spray-washing liquid directly acts on extracellular polymeric substances of vagina biomembranes, the compact structure of the extracellular polymeric substances is destroyed, and a permeation channel is opened for subsequent antibacterial components; meanwhile, pathogenic bacteria in vaginal biomembranes can be directly killed, the action mechanism of the antibacterial peptide is that bacterial cell membranes are physically damaged, and the pathogenic bacteria are not prone to generating drug resistance. The components such as the rose water can relieve discomfort such as pruritus, dryness and scorching hot caused by vaginal infection or improper cleaning, and are suitable for treatment scenes such as colpitis mycotica and abnormal leucorrhea, high in safety and wide in applicability.

The invention provides a cold-dampness-dispelling quick-acting sterilization and deodorization spray and a preparation method thereof. The cold-dampness-dispelling quick-acting sterilization and deodorization spray integrates quick-acting sterilization, cold-dampness-dispelling and long-acting deodorization. The spray comprises a component A and a component B which are stored separately, the component A contains acidic substances, fatty acid, chlorhexidine acetate, boric acid, menthol and chitosan, and the pH value of the component A is 4.0 + / -0.05; the component B contains sodium chlorite, plant essential oil, ethanol and polyvinylpyrrolidone, and the pH value of the component B is 9.0 + / -0.05. During use, the components are mixed according to a ratio of 1: 1 to trigger a chemical reaction to generate chlorine dioxide, so that rapid broad-spectrum sterilization is realized. The product is subpackaged by a double-cavity spray bottle, so that the active ingredients are prevented from reacting in advance, and the storage stability is ensured. The preparation method comprises the following steps: respectively preparing the component A and the component B, sub-packaging in a double-cavity bottle, and mixing and atomizing during use. The invention has fast-acting property, durability and safety, realizes the integration of sterilization, repair and deodorization through acid-base split charging design and instant reaction mechanism, and is suitable for application in multiple scenes of skin, clothes and environment.

The invention discloses a hydrocortisone compound ointment preparation for treating haemorrhoids, and belongs to the technical field of medicines. The technical problem to be solved is to provide a hydrocortisone compound ointment preparation which has a good hemorrhoid treatment effect and is stable. The hydrocortisone compound ointment preparation comprises the following components in percentage by weight: 0.15%-1% of corticoid, 0.025%-0.1% of a vasoconstrictor, 2%-4% of a local anesthetic, 0.1%-1.5% of L-menthol, 0.02%-0.5% of chlorhexidine acetate and 0.05%-1% of allantoin. The hydrocortisone compound ointment preparation disclosed by the invention has the medicinal effects of relieving pain and discomfort of patients suffering from haemorrhoids, promoting healing and repairing of haemorrhoids tissues, preventing infection and relieving inflammatory response, and has obvious effects of stopping bleeding and relieving swelling and pain in haemorrhoids treatment.

The invention discloses a parnassia palustris antibacterial liquid and a preparation method thereof, particularly relates to the technical field of disinfection and sterilization, and relates to the parnassia palustris antibacterial liquid and the preparation method thereof. According to the parnassia palustris antibacterial liquid, chlorhexidine acetate serves as a sterilization core, the irritation of the parnassia palustris antibacterial liquid is reduced through a hydroxypropyl-beta-cyclodextrin inclusion technology, and the parnassia palustris extract and zinc citrate are introduced to form a synergistic sterilization system; the invention discloses a parnassia palustris essence which is prepared from the following raw material components in parts by weight: 0.4 to 0.8 part of chlorhexidine acetate, 1.0 to 2.0 parts of hydroxypropyl-beta-cyclodextrin, 8 to 12 parts of propylene glycol, 0.1 to 0.3 part of zinc citrate, 0.3 to 0.7 part of parnassia palustris essential oil and 100 parts of parnassia palustris extract. Natural plant extracts and metal ions are introduced to construct a multi-target synergistic sterilization system with core components, and the components can efficiently cover and act on different life processes of microorganisms by utilizing a uniform atomized film formed by a spray formulation, so that a drug-resistant path of bacteria is effectively blocked, and the drug resistance of the bacteria is effectively inhibited. The purposes of keeping high efficiency after long-term use and not easily inducing drug resistance are achieved.

This invention discloses a long-acting antipruritic and antibacterial topical skin preparation, comprising N-ethyl-γ-L-glutamine, 1-1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphate-N-(L-γ-glutamyl-N-ethyl)-ethanolamine (POPE-N-Et-Gln-α), chlorhexidine acetate, and saffron extract as active ingredients, formulated into a hydrogel or cream with a pharmaceutically acceptable matrix. POPE-N-Et-Gln-α provides rapid transdermal action, while N-ethyl-γ-L-glutamine offers sustained-release and long-lasting effects; saffron extract provides anti-inflammatory and antioxidant effects, and chlorhexidine acetate provides antibacterial and antifungal effects. This invention is hormone-free and non-addictive, achieving both rapid and long-lasting antipruritic effects, and is suitable for eczema, urticaria, dry skin, neurodermatitis, psoriasis, microbial infections, and skin itching caused by insect bites.

The invention discloses a composition of a medical catheter lubricating hydrophilic coating and a preparation method of the composition, belongs to the technical field of medical materials, and aims to solve the problems of excessive swelling, poor combination stability, short service time, low cost and the like caused by uniform water absorption of a coating formed by curing a medical catheter hydrophilic lubricating coating composition in the prior art. In order to overcome the defects that an existing improvement scheme depends on a complex process, is high in cost and is easy to layer, the invention relates to the technical field of medical instruments, and comprises the following components in percentage by mass: 7-10% of polyvinylpyrrolidone; 1.5 to 2.5 percent of polyethylene glycol diacrylate; 0.8 to 1.2 percent of a silane coupling agent KH-570; the content of the medical grade 2-hydroxy-4-methoxyacetophenone is 0.1 to 0.2 percent; 62-68% of absolute ethyl alcohol; 14 to 18% of deionized water; 0.1 to 0.3 percent of chlorhexidine acetate; and 0.2 to 0.5 percent of citric acid. The composition has the property of spontaneously forming a gradient cross-linked structure, the gradient water absorption characteristic can be achieved under the conditions of conventional coating and single-condition curing, extra precise process control is not needed, the industrialization difficulty and cost are reduced, and meanwhile the problem that the binding force between multiple coatings is poor is solved.

The present invention proposes a skin antibacterial cream and a preparation process thereof, comprising the following raw materials: angelica, sophora flavescens, rhubarb, phellodendron chinense, brucea brucea, herba aconitifolii, notoginseng, scutellaria baicalensis, angelica dahurica, ligusticum chuanxiong, salvia miltiorrhiza, saltpeter, white pearl and chlorhexidine acetate. The present invention has the beneficial effects that after the Chinese medicine extract is prepared into an ointment for transdermal administration, the content of the active ingredient of the drug per unit area of ​​the epidermis can be increased, which is beneficial to improving the drug efficacy; at the same time, by selecting a suitable ointment type, the activity of the active ingredient of the Chinese medicine extract can be protected to prevent it from being inactivated or ineffective during long-term placement, so it is superior to injection and oral therapy, as well as smearing drug powder, for skin diseases, and can be used for a variety of skin diseases, with good efficacy, quick effect and no side effects; the skin antibacterial cream prepared by the preparation process of the skin antibacterial cream of the present invention has good skin feel, heat and cold resistance and long-term stability.

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a pharmaceutical composition containing a high-molecular complex for external use on skin and a preparation method of the pharmaceutical composition, and the pharmaceutical composition comprises the following components in percentage by weight: 0.1-0.3% of sodium humate; 0.8 to 1.4% of a bacteriostatic composition; 0.8 to 1.4% of a soothing composition; 0.12 to 0.14 percent of chlorhexidine acetate; 6-20% of a humectant; 1-3% of an emulsifier; 0.1%-0.5% of a functional auxiliary material; the balance of pure water; the antibacterial composition comprises a glabrous sarcandra herb extract, a radix sophorae flavescentis extract and a fructus cnidii extract; the soothing composition comprises an earthworm extract and a fructus kochiae extract. The sodium humate is compounded with other components, so that the inhibition effect of the composition on microorganisms such as candida albicans, staphylococcus aureus and escherichia coli can be improved. Meanwhile, the sodium humate can effectively repair and relieve skin mucosa, so that the skin is quickly recovered to a healthy state.

The invention discloses an aloe barbadensis leaf water composition for removing acnes and application thereof, and the composition is prepared from the following components in percentage by mass: 91 to 97 percent of aloe barbadensis leaf water, 1 to 4 percent of nicotinamide, 1 to 4 percent of arbutin, 0.1 to 0.4 percent of benzalkonium bromide and 0.1 to 0.6 percent of chlorhexidine acetate. The invention also provides a preparation method and application of the composition. The method comprises the following steps: weighing the raw materials in proportion, then mixing the aloe barbadensis leaf water, nicotinamide, arbutin, benzalkonium bromide and chlorhexidine acetate in a container, stirring and dissolving uniformly, sampling and detecting to be qualified, disinfecting and sterilizing, and finally, sealing, packaging and storing the aloe barbadensis leaf water, the nicotinamide, the arbutin, the benzalkonium bromide and the chlorhexidine acetate. The composition is used for preparing skin care products for removing acnes. The aloe barbadensis leaf water composition for removing acnes, prepared by the preparation method disclosed by the invention, adopts acnes-removing components derived from the nature, is safe in acnes removal without hurting the skin, restores the skin to a healthy state while repairing the damaged skin, and inhibits the re-breeding of acnes and bacteria.

The invention relates to the field of disinfectants, and particularly discloses a sterilization disinfectant and a preparation method thereof. The sterilization disinfectant is prepared from the following raw materials in parts by weight: 0.01 to 0.03 part of slow-release chlorhexidine acetate; and 0.82 to 0.84 part of 75% ethanol. The preparation method comprises the following steps: preparing slow-release chlorhexidine acetate; according to the proportion, the slow-release chlorhexidine acetate is mixed with 75% ethyl alcohol, the mixture is stirred to be uniform, and the sterilization and disinfection agent can be prepared. The sterilization disinfectant provided by the invention can be used for disinfecting hands, and has the advantages of improving the disinfection effect and prolonging the disinfection action time.

The invention provides a novel wound surface protection film coating agent as well as a preparation method and application thereof, and belongs to the technical field of trauma healing. The film coating agent provided by the invention is prepared from the following raw materials: polyacrylic resin, an ethyl acrylate-methyl methacrylate copolymer, povidone, dragon's blood and the like. The preparation method of the film coating agent comprises the following steps: adding chlorhexidine acetate, povidone, triethyl citrate and the like into 95% ethanol under low-speed stirring; adding polyacrylic resin, uniformly stirring, and swelling; adding the ethyl acrylate-methyl methacrylate copolymer, the antibacterial agent and the dragon's blood, and continuously stirring and uniformly mixing to obtain the film coating agent. The wound surface protection film coating agent is fast in film forming, can form a film within 1 min, is good in film integrity, can effectively absorb wound exudate, is good in antibacterial ability, can effectively prevent scar hyperplasia, and has a good treatment effect on wound surfaces such as scratches, stabbing wounds, scratches and scalds.

The invention belongs to the technical field of preparation of antibacterial preparations, and particularly relates to an antibacterial composition, an antibacterial nano-emulsion, an antibacterial preparation and application of the antibacterial composition, the antibacterial nano-emulsion and the antibacterial preparation. Through verification, the benzalkonium bromide and the chlorhexidine acetate can achieve the effect of synergistically resisting methicillin-resistant staphylococcus aureus (MRSA) by inhibiting or removing a biological membrane (cell membrane), and particularly, the nano-emulsion prepared from the benzalkonium bromide and the chlorhexidine acetate has an excellent MRSA resisting effect; the minimum inhibitory concentration (MIC) of the prepared nanoemulsion on MRSA bacteria is 1.5625 [mu] g / mL, and the minimum bactericidal concentration (MBC) of the prepared nanoemulsion on MRSA bacteria is 6.25 [mu] g / mL; in addition, the prepared nanoemulsion is low in toxicity and excellent in stability. Moreover, the antibacterial preparation disclosed by the invention is simple in preparation process, stable in quality and suitable for large-scale production, can be widely applied to infection of multiple drug-resistant bacteria of skin wounds, and has a good market application prospect.