9 results about "Membrane permeability" patented technology

The application discloses a novel preparation for inhibiting botrytis cinerea and application thereof, and relates to the technical field of bacteriostatic drugs, and has the technical scheme as follows: the active ingredient of the preparation is composed of isoeugenol and bacillus velezensis fermentation liquor.The half bacteriostatic concentration EC50 value of the novel preparation reaches 59.7 ug / mL, and the bacteriostatic capacity is higher than that of the existing technology of bacto in the same concentration.Based on the influence on the membrane permeability of filamentous fungi, the application can synergistically inhibit the pathogenic activity of postharvest fungi of fruits, and is expected to be used for preparing a novel preparation for preventing and treating high-sugar fruits after harvesting.The application is simple to use, environment-friendly, can be directly smeared on the surface of fruits in the planting stage, can not be directly contacted with the fruits in the storage period, and can provide the bacteriostatic capacity for the storage period by using the fumigation mode.The application provides a new choice for the biological prevention of fruits, and has good economic benefits and social benefits.

The invention relates to a method for providing a water-soluble adduct and an ibuprofen adduct, wherein the membrane permeability of the adduct is improved and the classification according to the Biopharmaceutics Classification System is influenced.

The application belongs to the technical field of microorganisms, and discloses application of shikimic acid in preparation of antibacterial preparations for inhibiting staphyloxin synthesis. It is found that shikimic acid can inhibit synthesis of staphyloxin in methicillin-resistant Staphylococcus aureus (MRSA), reduce tolerance of the bacteria to oxidative stress, induce accumulation of intracellular active oxygen, and damage cell membrane structure and function, including reducing cell membrane order, inducing membrane depolarization, increasing membrane permeability, and leading to ATP leakage and energy metabolism disorder. A new strategy and preparation direction are provided for clinical treatment of multi-drug resistant Staphylococcus aureus infection, and the application has important theoretical value and application prospect.

The membrane permeability robust prediction method based on working condition adaptive division belongs to the field of sewage treatment and resource utilization. Due to the influence of different working conditions on the MBR sewage treatment process, unbalanced samples exist in the membrane pollution related data, which may reduce the prediction performance. In order to solve this problem, the present application proposes a membrane permeability robust prediction method based on working condition adaptive division to predict the membrane permeability. First, a cross-entropy index based on spatial membership calculation is proposed, which can adaptively divide the membrane pollution related data set by evaluating the data fluctuation characteristics of the input information; second, a nonlinear regression model is used to predict the membrane permeability. The results show that the method can effectively predict the value of the membrane permeability.

This invention relates to a method for the simultaneous removal of antibiotic-resistant bacteria and resistance genes using a solar-driven interfacial heat-Fenton oxidation-like process. The method involves placing a photothermal film loaded with carbon black composite photothermal material in a photothermal sterilization reactor, introducing antibiotic-resistant wastewater, adding H2O2, turning on a xenon lamp to preheat the photothermal film, sealing the reactor, and allowing the wastewater to pass through the photothermal film under gravity. This invention utilizes a photothermal conversion material to absorb light radiation and convert it into thermal radiation, treating antibiotic-resistant bacteria through the high-temperature interfacial heat effect generated on the photothermal film. High-temperature interfacial heat causes localized heating of the bacterial cell membrane structure, leading to a certain degree of breakage of fatty acid chains in the bacterial membrane lipid bilayer. This increases cell membrane permeability, and the resulting physical damage damages the bacterial outer membrane structure, further increasing membrane permeability and thus disrupting membrane integrity.

This invention discloses a drug-loaded microcapsule-type controlled-release formulation of trigonelline and its preparation method. The method includes: using microcrystalline cellulose pellets as an inert carrier, sequentially loading a trigonelline drug-loaded layer, a hydroxypropyl methylcellulose isolation layer, and a composite controlled-release membrane layer composed of ethyl cellulose, RS / RL acrylic resin, triethyl citrate, and talc using bottom-spray fluidized bed coating technology; and then filling the mixture into capsules after curing. This invention effectively isolates the drug from the controlled-release membrane layer through the isolation layer and utilizes the RS / RL resin compound to synergistically regulate membrane permeability, achieving stable controlled release of trigonelline. The resulting formulation shows a release rate of no more than 25% in 0.1 mol / L hydrochloric acid after 2 hours, and release rates of 20%-45%, 45%-75%, and 70%-95% after 4 hours, 8 hours, and 12 hours in pH 6.8 buffer solution, respectively. The release behavior is stable and controllable, effectively solving the problem of burst release of highly water-soluble drugs and prolonging the duration of action.

The application belongs to the technical field of nanofiltration membranes, and discloses a eutectic solvent-induced furan bio-based composite polyamide nanofiltration membrane, and a preparation method thereof, which comprises four steps of synthesis of difuran dimethylamine monomers, pretreatment of an ultrafiltration membrane, preparation of an aqueous phase / organic phase solution, and interfacial polymerization to form a membrane; the interfacial polymerization aqueous phase is a mixed solvent of a eutectic solvent-water, the difuran dimethylamine is a monomer, and the organic phase is a polyacyl chloride solution.The difuran dimethylamine with a biomass source is used as the monomer, and dependence on petroleum-based raw materials is eliminated; the eutectic solvent is used to solve the bottleneck of poor water solubility of the furan monomer, the monomer diffusion kinetics is controlled through high viscosity of the eutectic solvent, excessive cross-linking is inhibited, a uniform and dense polyamide separation layer is formed, the trade-off effect between traditional membrane permeability and selectivity is broken, and the synergistic improvement of high water flux and ultra-high Mg 2+ / Li + separation selectivity is realized, the prepared nanofiltration membrane has excellent permeability and magnesium-lithium separation efficiency, and can be widely applied in the fields of water treatment and lithium extraction from salt lakes.

The utility model relates to the field of cyclic peptide membrane observation discloses a kind of cyclic peptide membrane permeability observation device, including device base, the inner wall of device base is slidably connected with moving block, the inner wall of moving block is provided with limit mechanism, the inner wall of device base is fixedly connected with square, the top inner wall of device base is elastically connected with sliding block by tension spring, the bottom of sliding block is provided with wheel, sliding block is provided with multiple groups, multiple groups sliding block are connected by cross bar, the top of device base is provided with detection device, the top of device base is provided with container, the limit mechanism includes L-shaped plate.In the utility model, by setting moving block, L-shaped plate and sliding block, wheel and other components, wheel can be quickly exposed device and contact with ground, it is convenient for subsequent whole device to adjust its position on plane, change the defect that part cyclic peptide membrane permeability observation device cannot be safely moved.

The invention relates to a method for providing water-soluble taxane formulations, in particular a paclitaxel formulation and water-soluble formulations of paclitaxel derivatives, wherein the membrane permeability and the efficacy of paclitaxel and paclitaxel derivatives are improved and the classification according to the Biopharmaceutics Classification System is influenced.