131 results about "Membrane permeabilization" patented technology

The invention discloses a baicalin and boric acid antibacterial peptide assembly and a preparation method and application thereof, belongs to the technical field of biological medicine, and provides a baicalin and boric acid antibacterial peptide assembly which comprises baicalin and boric acid antibacterial peptide. The amino acid sequence of the boric acid antibacterial peptide is one of SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4, SEQ ID NO. 5 or SEQ ID NO. 6. According to the baicalin and boric acid antibacterial peptide assembly, phenylboronic acid molecules introduced to the C end of boric acid antibacterial peptide polypeptide can form boric acid ester bonds with the baicalin, the water solubility and membrane permeability of the baicalin can be improved, the baicalin can enter bacterial cells more easily to play a role, and the baicalin and the boric acid antibacterial peptide can form a multi-target synergistic antibacterial effect; therefore, the antibacterial effect is obviously improved.

A membrane fouling monitoring and analysis system may be used on a food and beverage membrane operated over a plurality of production periods separated by daily clean-in-place cleanings. In some examples, the system receives data indicative of a flow of one or both of a permeate stream and a retentate stream of the membrane during the plurality of production periods and determines a trend of at least one parameter associated with the data to provide a determined trend. The system may compare the determined trend to a baseline fouling trend and determine if and / or when to perform a deep cleaning on the membrane based on comparison. The system may subsequently execute the deep cleaning on the membrane at the scheduled time.

The invention discloses a treatment system for removing scale-forming ions in a water body and a working method.The treatment system comprises an anode plate, an anode diaphragm, a cathode diaphragm and a cathode plate, and an anode chamber, a deionized water chamber and a cathode chamber which are mutually independent, and aqueous solutions in the anode chamber and the deionized water chamber can be mutually communicated only through a micropore structure on the surface of the anode diaphragm; and the aqueous solution in the cathode chamber and the aqueous solution in the deionized water chamber can be communicated with each other only through the microporous structure on the surface of the cathode diaphragm. According to the invention, the membrane permeation mass transfer mechanism is applied in the electrochemical reaction process, so that ions in the system are enriched on the surfaces of two poles and are removed through reaction, the descaling efficiency of the reactor is improved, and the method has the characteristics of strong applicability and simple operation steps.

The invention discloses a trace water vapor removal device and method based on a membrane permeation technology, and relates to the technical field of online total sulfur analysis, the trace water vapor removal device specifically comprises a membrane drying assembly, the membrane drying assembly comprises a through exchange cavity, a top cover and a bottom cover, the through exchange cavity serves as the center, the top cover is fixed to the top of the through exchange cavity through a bolt, and the bottom cover is fixed to the bottom of the through exchange cavity through a bolt; a bottom cover is fixed at the bottom; an intelligent adjustment and efficient dehydration structure is adopted, the humidity of reaction gas is monitored in real time through a humidity sensor, data are fed back to an external controller, and intelligent linkage adjustment of the opening size of the movable ventilation pipe and the power of the circulating pump is achieved; the dynamic regulation and control mechanism can automatically optimize the flow rate of purge gas and the water-gas exchange area according to the actual humidity change, and it is ensured that the efficient and stable dehydration effect can be achieved under different working conditions.

There is provided a method for producing a product by cells, the method including filtering a cell broth through a porous membrane to obtain a product by the cells, in which the porous membrane has a liquid contact surface having at least any one selected from the group consisting of an opening ratio of 57.5% or less, a pore diameter having a coefficient of variation of 0.5 or less, and a ratio of pore diameter / fiber diameter of 1.3 or less, and the liquid contact surface has at least any one selected from the group consisting of a structural anisotropy of 0.97 or more and 1.03 or less and a ratio of long pore diameter / short pore diameter of 1.8 or less, and a shear stress due to a flow of the cell broth on the liquid contact surface is set to 4.0 N / m2 or less.

The present disclosure provides a carrier peptide fragment with excellent cell membrane permeability. The carrier peptide fragment disclosed herein includes the following amino acid sequence set forth in SEQ ID No.: 1: KKRTLRKSNRKKR, and a lysine residue at a 12th position from an N-terminus of the amino acid sequence is a D-form, and the other amino acid residues are L-forms.

TITLE OF THE INVENTION: DEVICE AND METHOD FOR SEPARING MIXED DIHYDROGEN IN A NATURAL GAS NETWORK A device (35) for separating mixed dihydrogen in a natural gas network, comprising: - an inlet pipe (11) for a gaseous mixture of dihydrogen and natural gas, said inlet pipe including a flow meter (14), - a first outlet (33) for a first gaseous mixture enriched in dihydrogen, - a second outlet (26) for a second gaseous mixture depleted in dihydrogen, said second pipe including a sensor (22) for a dihydrogen concentration, - at least two membrane permeation separation modules (20-1, 20-2, 20-3, 20-4, 20-5) mounted in parallel, producing a retentate discharged through the first outlet and a permeate discharged through the second outlet, connected to the general inlet pipe via a connector (16) comprising a valve (17),and - an automated control system (34) for each valve, determining the number of open valves based on the gas mixture flow rate and the dihydrogen concentration, and controlling the actuation of all or part of the valves according to the determined number. Figure for the abbreviation: Figure 1,

The invention discloses a preparation method and application of a silicon-based functionalized fluorenyl polysubstituted acetylene copolymer and a gas separation membrane thereof. Belongs to the technical field of polymer material and gas separation. The invention provides a new thought for preparation of a high-permeability gas separation membrane material. The preparation method comprises the following steps: carrying out copolymerization on 1-phenyl-2-(7-trimethylsilyl-9, 9-bis (trimethylsilyl-fluorene-2-yl) acetylene and 1-phenyl-2-(7-trimethylsilyl-9, 9-dimethyl-fluorene-2-yl) acetylene under the catalysis of TaCl5-n-Bu4Sn, so as to prepare a copolymer with high molecular weight; the preparation method comprises the following steps of: carrying out film casting on a solution of the nano-silver oxide, and then carrying out desiliconization treatment by using normal hexane / trifluoroacetic acid to obtain a gas separation membrane with the thickness of 100-220 microns, the specific surface area of 298-492 m / g and the total pore volume of 0.134-0.299 cm / g. The prepared separation membrane has the advantages that the COpermeability is up to 36,900 Barrer, the Opermeability is 19,800 Barrer, the thermal decomposition temperature exceeds 420 DEG C, the separation membrane can be used for separating gases such as COO, ON and the like, the preparation process is simple and convenient, and the industrial potential is realized.

The invention relates to a method and system for preparing isobutene from tert-butyl alcohol, and the method comprises the following steps: S1, hydrolyzing initial tert-butyl alcohol to obtain a first product containing water, isobutene and unreacted tert-butyl alcohol; s2, performing membrane permeation separation on the first product to obtain a water permeate and a retentate containing isobutene and unreacted tert-butyl alcohol; s3, performing flash evaporation separation on the retentate to obtain gas-phase isobutene and liquid-phase tert-butyl alcohol; circulating the liquid-phase tert-butyl alcohol and repeating the steps S1 to S3 until the total conversion rate of the initial tert-butyl alcohol reaches a preset value; rectifying the liquid-phase tert-butyl alcohol, all water permeates and all gas-phase isobutene obtained in the last-stage circulation to obtain high-purity isobutene, water-tert-butyl alcohol azeotrope and wastewater; the water-tert-butyl alcohol azeotrope is extracted from the side line of the rectifying stripping section and returns to S2 for recycling. Through cyclic coupling of hydrolysis, membrane permeation separation, flash separation and rectification, high-purity isobutene is obtained, the conversion rate of tert-butyl alcohol is high, and the discharge amount of wastewater is low.

The invention provides a method for preparing a homoporous straight-through membrane from a non-solvent-induced phase separation quaternary system, which mainly comprises the following steps: firstly, mixing a metal compound, a high-molecular polymer, a polar solvent and a pore-foaming agent according to a certain proportion, and fully stirring at 30-80 DEG C to form a homogeneous membrane casting solution; then uniformly blade-coating a porous cloth or an inorganic glass plate with the membrane casting solution, evaporating a film obtained by blade-coating at room temperature for a certain time, transferring the film into a 25-75 DEG C deionized water coagulating bath, and coagulating to form a membrane; and finally, soaking the solidified membrane in absolute ethyl alcohol to remove impurities, taking out the membrane, and airing to obtain the uniform-pore membrane with uniform membrane pores and finger-shaped through pore structures. The preparation method of the uniform-hole straight-through membrane provided by the invention is simple and easy to operate, and the used solvent is non-toxic, green and environment-friendly; the prepared homoporous membrane is good in permeability, high in selectivity and high in strength, can be applied to the fields of water treatment, biomedicine or protein separation and the like, and has a wide application prospect.

The present invention discloses a method for promoting membrane fouling resistance of an anaerobic membrane bioreactor under the action of an electric field and its application, belonging to the technical field of in-situ control of membrane fouling. In the process of treating sewage, the present invention adopts a Ni / Fe LDH@C-BIO hybrid synthesized by coprecipitation and electrostatic attraction to prepare an anaerobic membrane bioreactor, and performs an electrochemical redox reaction under the action of an external electric field to achieve membrane fouling resistance. The Ni / Fe LDH@C-BIO hybrid used in the anti-membrane fouling method has a large amount of positive charge on its surface and can quickly hybridize with anaerobic sludge with a negative charge on its surface. The external electric field promotes the regulation of the electrical activity of the anaerobic sludge EPS, decomposes the main pollutants that cause membrane clogging, and alleviates the deposition of microbial flocs and their metabolites. At the same time, the LDH with acidified activated carbon as a conductive substrate has excellent specific surface area catalytic performance and conductive performance, accelerates electron transfer, thereby further improving the reaction rate and effectively improving the anti-fouling ability and membrane permeability of the membrane assembly of the anaerobic membrane bioreactor.

This invention discloses an acid and alkali resistant polyamide membrane and its preparation method. The method is as follows: S1: Immerse the ultrafiltration base membrane in an aqueous sodium hydroxide solution for soaking and then set aside; S2: Treat the base membrane with a mixed aqueous solution of polyamine and aziridine crosslinking agent; S3: Wet the base membrane in an organic phase solution of polyacrylamide monomer to obtain a polyamide composite membrane; S4: Immerse the prepared polyamide composite membrane in an alcoholic solution of hydroxymethyl crosslinking agent, then dry it in a forced-air drying oven, and after washing with water, obtain the acid and alkali resistant polyamide membrane. This application uses two crosslinking agents, aziridine and hydroxymethyl, which can undergo specific crosslinking reactions with the carboxyl groups inside the polyamide membrane, to directly perform dual crosslinking modification on the membrane interior and surface, without introducing other polymer materials to avoid excessive increase in membrane permeation resistance. The polyamide membrane prepared by this method has both good acid and alkali resistance and water permeability.

Processes and systems are provided for treating the tail gas stream of a sulfur recovery plant. The process comprising the steps of treating the compressed tail gas stream in a pre-treatment unit to remove the impurities; separating the dry stream in a first stage membrane unit, the first stage membrane unit comprises a membrane selective to carbon dioxide and hydrogen; reducing a temperature of the cryogenic feed in a cryogenic cooler to produce a cryogenic stream; separating the cryogenic feed in a knock-drum to produce a liquid carbon dioxide and membrane feed; separating the membrane feed in a second stage membrane unit to produce a rubbery membrane permeate and a rubbery membrane retentate, where the second stage membrane unit comprises a membrane selective to carbon dioxide over hydrogen; and treating the rubbery membrane retentate in a hydrogen recovery process to produce a hydrogen product stream and a carbon dioxide lean stream.

The present invention provides a spiral membrane element suitable for suppressing a decrease in a permeation rate (or a permeation flux) of a permeated fluid from a separation membrane. A spiral membrane element of the present invention includes: a central tube; a membrane leaf that has a separation membrane and a permeation spacer and is wound around the central tube; and a flow passage spacer that is connected to the permeation spacer and is wound around the central tube on a side closer to the central tube than the membrane leaf is. A pressure loss of the flow passage spacer measured by a predetermined test is smaller than a pressure loss of the permeation spacer.

The purpose of this invention is to provide a method for preparing a mixed matrix membrane for CO2 / CH4 separation, belonging to the field of gas separation technology. This method prepares a mixed matrix membrane by incorporating Cu(Qc)2 into a 6FDA-DAM matrix, which improves the limiting effect between the permeability and selectivity of the 6FDA-DAM membrane and greatly enhances the CO2 permeability coefficient and CO2 / CH4 selectivity.

The invention discloses thiazolidinedione or a derivative thereof as well as a preparation method and application thereof, the structural formula of the thiazolidinedione or the derivative thereof is non-substituted or randomly substituted by at least one R, and R is halogen or hydroxyl. An activity detection experiment and a compound dissociation constant test experiment on the inhibition activity of aldose reductase and alpha-glucosidase on the compound prove that the compound disclosed by the invention is an efficient AKR1B1 / alpha-GC double-target inhibitor with excellent membrane permeability, and is capable of relieving hyperglycemia while preventing abnormal metabolism of polyhydric alcohols; by utilizing a double-target collaborative intervention strategy, the application prospect in preparation of related medicines for preventing and / or treating diabetic complications is good.

The present invention provides a physiologically active peptide derivative for use in the treatment of ocular diseases having a physiologically active peptide sequence and a functional sequence comprising a membrane permeation enhancing sequence and an endosome escape enhancing sequence.

This invention relates to a PDMS / PAN composite membrane based on a chemically modified PAN membrane, which is composed of a PAN substrate membrane sequentially modified with NaOH and GMA and grafted with methacrylate-functionalized PDMS. The invention also relates to a method for preparing the above membrane, which involves sequentially chemically modifying the PAN substrate membrane with NaOH and GMA in two steps to introduce acrylate double bonds onto the surface of the PAN membrane, followed by further photopolymerization grafting of a PDMS selective layer to prepare the PDMS / PAN composite membrane. This improves the adhesion of the PDMS selective layer, effectively mitigating cracking and delamination phenomena in practical applications of the PDMS / PAN composite membrane. Simultaneously, the membrane's performance in pervaporation and ethanol separation is significantly enhanced, greatly improving the application prospects of PDMS membranes in actual pervaporation processes.

The application discloses a method for improving the flux and hydrophobicity of a uniform pore membrane by selective fluorination, comprising the following steps: immersing a uniform pore membrane with a pore size of 5-100 nm and containing carboxyl functional groups into a reaction solution, wherein the reaction solution comprises a silver salt catalyst with a mass concentration in the range of 0.1-3.5 wt%, a fluorination reagent with a mass concentration in the range of 0.15-5.5 wt%, an oxidizing agent with a mass concentration in the range of 0.05-7.5 wt%, a co-catalyst with a mass concentration in the range of 0.15-5.5 wt%, water and an organic solvent with a mass concentration in the range of 5-65 wt%; reacting at 4-60 DEG C for 15 min-72 h, taking out the membrane, and then sequentially cleaning the membrane with ethanol and deionized water to obtain a uniform pore membrane with good membrane flux and hydrophobicity. The application improves the permeability and separation selectivity of the uniform pore membrane by selective fluorination, and the uniform pore membrane is not damaged, and the method has universality.

Provided is a membrane permeation promoter that promotes permeation of a conjugate of a target substance and a transmembrane peptide into a lipid bilayer membrane, the membrane permeation promoter containing a flavonoid. Also provided are a membrane permeation promoting method and intracellular delivery method using the membrane permeation promoter, and an intracellular delivery kit comprising the membrane permeation promoter.

The present disclosure provides a performance prediction method and system for a fuel cell in an anode recirculation mode. The method includes: calculating output results of a membrane water transfer equation, a liquid water transfer equation, and a temperature transfer equation based on the membrane water transfer equation, the liquid water transfer equation, and the temperature transfer equation inside the fuel cell; calculating output results of a gas transfer equation based on output results of a first labeling equation according to a phenomenon of nitrogen transmembrane permeation inside the fuel cell; determining gas state parameters in the anode recirculation mode based on the output results of the temperature transfer equation and the gas transfer equation; and predicting output voltage performance of the fuel cell based on the gas state parameters in the anode recirculation mode and output results of a second labeling equation.

The invention discloses an AcrB efflux pump inhibitor with a membrane permeabilization effect as well as a preparation method and application thereof. The AcrB efflux pump inhibitor is a solvent compound, an enantiomer, a diastereoisomer, a tautomer or a mixture of a compound with a structure as shown in a formula I or pharmaceutically acceptable salt of the compound, wherein R is C6-C16 straight chain or branched chain alkyl, alkenyl, ester group, amide or substituted phenyl; x is N or C; y is N or C. The compound provided by the invention has better efflux inhibition activity, and the minimum inhibitory concentration can be reduced by 64 times when the compound is combined with minocycline for use.

Installation and method for treating a feed gas stream (1) comprising carbon dioxide and methane by membrane permeation, said feed gas stream comprising at least 90 mol% carbon dioxide and between 0.5 and 10 mol% methane, and said apparatus comprising a compressor (8) configured to compress the feed gas stream (1) to a pressure between 2 barg and 16 barg, a membrane separation unit (3) configured to receive the feed gas stream (1) and to provide a permeate (2) and a retentate (4), a feed line (5) for the feed gas stream (1) to the membrane separation unit (3), and a retrieval line (9) for the retentate (4) configured to send the retentate (4) to a biogas production and / or storage unit. Abbreviated figure: Fig. 1

The invention discloses a polypeptide and an application of the polypeptide in preparation of antibiotics. The amino acid sequence of the polypeptide is LRDLVCYCRS10 RGCKGRERMN20 GTCRK25. According to the invention, it is found that L-Crp1 tends to form a double alpha-spiral structure in a membrane environment, the double alpha-spiral structure can fully expose alkaline residues, and the double alpha-spiral structure closely interacts with a microbial membrane and mediates membrane permeation of polypeptide, which is the key of the strong bactericidal activity of L-Crp1 to escherichia coli; however, the disordered segment of the C end of the L-Crp1 peptide chain does not participate in the interaction with the membrane, the polypeptide obtained after the segment is cut off still has a complete double-alpha-spiral structure, the bactericidal activity of the polypeptide is equivalent to that of the L-Crp1, but the length of the peptide chain of the polypeptide is shorter than that of the L-Crp1, so that the production cost is greatly reduced (reduced by 30-40%), and the polypeptide has greater application potential than the L-Crp1.

We provide novel, specific cytotoxic drug therapies with minimal side effects. [Solution] A composition for a membrane-permeable complex for transport across a lipid membrane is provided, comprising one or more molecular induction system (MGS) peptides and a cytotoxic agent. A method for treating cancer is also provided, comprising administering this composition to a cancer patient.

Processes and systems arc provided for treating the tail gas stream of a sulfur recovery plant. The process comprising the steps of treating the compressed tail gas stream in a pre-treatment unit to remove the impurities; separating the dry stream in a first stage membrane unit, the first stage membrane unit comprises a membrane selective to carbon dioxide and hydrogen; reducing a temperature of the cryogenic feed in a cryogenic cooler to produce a cryogenic stream; separating the cryogenic feed in a knock-drum to produce a liquid carbon dioxide and membrane feed; separating the membrane feed in a second stage membrane unit to produce a rubbery membrane permeate and a rubbery membrane retentate, where the second stage membrane unit comprises a membrane selective to carbon dioxide over hydrogen; and treating the rubbery membrane retentate in a hydrogen recovery process to produce a hydrogen product stream and a carbon dioxide lean stream.

There is provided a method for producing a product by cells, the method including filtering a cell broth through a porous membrane to obtain a product by the cells, in which the porous membrane has a liquid contact surface having at least any one selected from the group consisting of an opening ratio of 57.5% or less, a pore diameter having a coefficient of variation of 0.5 or less, and a ratio of pore diameter / fiber diameter of 1.3 or less, and the liquid contact surface has at least any one selected from the group consisting of a structural anisotropy of 0.97 or more and 1.03 or less and a ratio of long pore diameter / short pore diameter of 1.8 or less, and a shear stress due to a flow of the cell broth on the liquid contact surface is set to 4.0 N / m2 or less.

According to the technical scheme, the membrane integrated treatment process mainly comprises the following steps: firstly, the food pickling high-salinity wastewater enters a wastewater collection tank, and sequentially enters an inorganic silicon carbide ceramic membrane pretreatment system and a silicon carbide ceramic membrane through a delivery pump to filter and remove pollutants such as suspended solids; the silicon carbide ceramic membrane concentrated liquid is subjected to outsourcing treatment; the silicon carbide ceramic membrane penetrating fluid enters a nanofiltration membrane treatment system to obtain nanofiltration concentrated water and nanofiltration produced water, the nanofiltration concentrated water is subjected to catalytic oxidation through an ozone catalysis tower, and wastewater without COD, NH3-N, plant washing water and the like enters a biochemical treatment-MBR (AAO / MBR) membrane treatment system together to be discharged after reaching the nanotube standard; the nanofiltration produced water is divided into two streams, one stream is recycled for pickling, and the other stream passes through a bipolar membrane system to prepare hydrochloric acid and liquid caustic soda which are applied to acid-base regulation in a factory area. The method provided by the invention realizes recycling of food pickling wastewater, and has the advantages of high efficiency, stability, energy conservation, consumption reduction and the like.

A novel reverse osmosis or nanofiltration (RO / NF) system is developed that utilizes a uniquely configured membrane permeate flow path within the system to detect and respond to the onset of fouling, generating time-sensitive data. Membrane performance data under real-time operating conditions is then used to rapidly detect membrane fouling, fouling rate, and fouling causes. Subsequently, controller-based system-generated actions are employed to stop fouling and recover from or slow it down. Furthermore, operator intervention steps are anticipated, planned, and scheduled, if necessary, to restore optimal system operating conditions. The end result is a novel, energy-efficient, and advanced (machine learning) reverse osmosis system for brackish water desalination and fouling management.