463 results about "Target site" patented technology

The invention relates to the field of field engineering characteristic evaluation, in particular to a fracture characteristic calculation method based on resistivity tomography and resistivity static sounding. The method comprises the steps that firstly, in-situ site resistivity parameter calibration is carried out through a resistivity static sounding (RCPTU) test technology, and a resistivity index background value of a target site is obtained; then, acquiring an initial value of the electrical resistivity of the whole area of the target site by adopting a three-dimensional electrical resistivity tomography (ERT) technology; and finally, according to the resistivity-fracture inversion model, identifying the fracture distribution condition of the whole region of the target site, and giving a fracture rate evaluation model of the target site. According to the method, the precision problem of single in-situ test equipment is solved, the test precision of site three-dimensional resistivity parameters is improved, the reliability of three-dimensional inversion calculation is improved, and the three-dimensional space distribution of the soil body fractures can be evaluated quickly, nondestructively and accurately.

The invention discloses a highway accident scene sensing system based on AI identification and unmanned aerial vehicle cooperation, and relates to the technical field of intelligent traffic. Comprising a central planning node for fusing geographic information, meteorological information and road obstacle information of a target site with the real-time state of an unmanned aerial vehicle, constructing a digital twin scene model, generating an initial four-dimensional collaborative awareness route plan, and dividing sub-airspaces; the distributed airborne intelligent agent obtains peripheral multi-source data of the unmanned aerial vehicle, constructs a surrounding environment real-time situation map through an AI recognition algorithm, and determines a flight instruction of the unmanned aerial vehicle according to the surrounding environment real-time situation map and the divided sub-airspace; and the reconfigurable intelligent metasurface is used for adjusting surface electromagnetic characteristics according to the divided sub-airspaces and sending directional beams to the unmanned aerial vehicle. Therefore, the problems of cooperative scheduling, obstacle avoidance and communication guarantee of multiple unmanned aerial vehicles in a complex accident scene are effectively solved, and the efficiency and safety of emergency disposal are remarkably improved.

The invention relates to a site micro-vibration attenuation test measuring point determination method and system, belongs to the technical field of vibration test, and solves the problem that vibration test measuring point arrangement depends on vibration source load accuracy or artificial experience in the prior art. The method comprises the following steps: determining a basic measuring point based on a target site parameter, obtaining an actual measurement vibration response, and calculating an actual measurement response transfer ratio; establishing an initial finite element model of the target site, and applying a preset load to the initial finite element model to obtain an initial finite element calculation result; according to the basic measuring points, corresponding model calculation points and predicted vibration responses are extracted, and predicted response transfer ratios are calculated; and performing model parameter updating by using the actually measured response transfer ratio and the predicted response transfer ratio, obtaining a basic finite element model, generating a vibration transfer form curve, obtaining vibration transfer characteristics, and determining the number and the positions of the measuring points. The micro-vibration transmission characteristics are accurately determined without depending on the vibration source load, and the number and the positions of the vibration attenuation test points are reasonably formulated.

The invention provides a radiotherapy plan generation method and device, equipment and a medium, and the method comprises the steps: obtaining a target function image of a target object; the target function image comprises a target region, an organ at risk and a target part; determining target dose information of the target part based on the target function image, the target function partitioning result, the target region segmentation result and the endangered organ segmentation result; the target function partitioning result is used for indicating spatial distribution of a plurality of functional regions of the target part divided according to the functional state, and the target dose information comprises doses of different regions of the target part; and generating a radiotherapy plan based on the target dose information. By applying the embodiment of the invention, the set dose information of the target part is more reasonable, so that the radiotherapy plan generated based on the target dose information can ensure the accuracy of tumor control, reduce the risk of radioactive injury and realize targeted protection of the target part.

The invention discloses a fan site selection method and system based on different-mode nested grids, and belongs to the technical field of fan site selection, and the method comprises the steps: firstly constructing a large-region sea ice background field by using global data to preliminarily screen candidate regions, then constructing a small-region high-resolution background field through a grid nesting technology, and carrying out the dynamic simulation, according to the method, a sea ice evolution field is obtained, an initial field is corrected by fusing field and satellite data, errors are quantized, comprehensive scoring is carried out to screen target site selection, finally, simulation parameters are dynamically optimized according to actually measured data, and a final site selection is determined through iterative correction. According to the method, multi-scale evaluation from macroscopic preliminary screening to microcosmic fine screening is realized, and through data fusion and dynamic optimization, the precision and reliability of fan site selection in a complex sea ice environment are remarkably improved.

Provided is a reverse prime editing system, which is used for achieving site-specific and precise small-fragment DNA editing upstream of a target site. In the reverse prime editing system, a targeted strand nickase (such as D10A-Cas9) is used to cleave a nick on a targeted strand, thereby enabling precise small-fragment DNA base insertion, deletion and substitution upstream of the target site under the action of a reverse transcriptase.

The present invention provides an elongated member for positioning a medical device at a target site within a body lumen. [Solution] The elongated member may include one or more articulated joints for maneuvering, one or more transducers for positioning, and one or more lumens for delivering the instrument to a target site. Some embodiments, in particular, relate to medical devices that guide an operator to a target site, confirm the location of the target site, enable a biopsy to be taken from the target site, and / or deliver treatment to the target site. For example, a position tracking sensor may be used to guide the medical device to the target site, a phased array sensor may be used to confirm proper positioning at the target site, and a biopsy needle inserted through a lumen may be used to take a sample from the target site.

The embodiment of the specification discloses a kind of station risk identification rule processing method, device and equipment, the method comprises: obtaining the site information of target network site to be identified;Based on the preset site identification demand information, corresponding prompt information is constructed, based on prompt information, using first large language model, generate first risk identification rule for target site based on site information;The first risk identification rule is extended and handled, and the rule population for target site is obtained;Each rule in the rule population is evaluated by a plurality of different modes by a preset multi-modal large model, to obtain the evaluation result of rule population;Based on the evaluation result of rule population, the rule population is iteratively optimized by difference evolution algorithm, to obtain the optimized rule population, based on the optimized rule population, determine the risk identification rule for target site.

A fiber optic treatment tool system according to the present invention comprises: a treatment tool that treats tissue of an observation target site; a light-emitting unit that emits light in a wavelength band that excites a fluorescent reagent contained in a drug bound to the observation target site; a light guide part that is configured using an optical fiber and that guides light between one end and the other end thereof; a light-receiving unit that detects return light from the treatment tool or the observation target site incident on the light guide part; and a control unit that controls the intensity of the light emitted by the light-emitting unit. The light guide unit has one end located at the end of the treatment tool on the observation target site side and the other end connected to the light-emitting unit and the light-receiving unit. The control unit reduces the light emission intensity of the light-emitting unit when the intensity value of the return light acquired from the light-receiving unit is equal to or greater than a preset threshold value.

The present disclosure relates to a delivery device such as a pusher for delivering a medical device such as a stent through tortuous anatomy while reducing twisting or flattening. The delivery device may also aid in expansion of the medical device upon reaching a target site. The delivery device may include a core wire and one or more coils disposed around the core wire. The one or more coils may function to effectively stiffen and / or increase the outer diameter of the delivery device along certain portions of its length.

A computer system that performs pairwise harmonization is described. During operation, the computer system may receive information specifying magnetic-resonance diffusion measurements, where the magnetic-resonance diffusion measurements are associated with at least an individual and a first site. Then, the computer system may perform the pairwise harmonizing of the magnetic-resonance diffusion measurements based at least in part on target magnetic-resonance diffusion measurements, where the target magnetic-resonance diffusion measurements are associated with a population and one or more target sites, and the magnetic-resonance diffusion measurements and the target magnetic-resonance diffusion measurements may be acquired using different magnetic-resonance scanners. Next, the computer system may perform quality control on the pairwise harmonized magnetic-resonance diffusion measurements, where the quality control may include comparing the pairwise harmonized magnetic-resonance diffusion measurements associated with the first site and the one or more target sites.

The invention provides a dose optimization method and device, equipment and a medium, and the method comprises the steps: obtaining a functional image of a target object and the initial dose information of a target part; the functional image comprises a target part, and the initial dose information comprises initial doses of different areas in the target part; determining a damage prediction result of the target part through a pre-trained damage prediction model based on the functional image and the initial dose information; the damage prediction result is used for indicating the probability of radioactive damage at each position in the target part; based on the damage prediction result, optimizing the initial dose information to obtain target dose information of the target part; the target dose information comprises target doses of different areas in the target part. By applying the embodiment of the invention, the dose optimization effect can be ensured, the risk of radioactive injury of the target part is reduced, and the protection effect on the target part is improved.

Systems and methods for sealing tissue sites may comprise coring tissue at a target site such that a tissue core is removed from the target site thereby creating a core cavity at the target site and causing sealing of at least a portion of the target site.

An implantable device includes two or more alignment marker elements, and a system and method for manufacturing such an implantable device, as well as a method for utilizing such an implantable device. For example, an implantable device may include a first alignment marker element and a second alignment marker element, which can be used to ensure proper alignment with a target site.

The invention discloses a distributed transaction processing method and system, and belongs to the technical field of database systems, the method is suitable for a distributor, and the method comprises the following steps: obtaining transaction processing information of a current to-be-processed transaction, determining a target site for processing the transaction, sending the transaction processing information to the target site, and sending the transaction processing information to the target site; after the target site receives the transaction processing information, if new transaction processing information is not received within a preset time period, transaction processing is carried out according to the transaction processing information, and a transaction processing result is obtained and fed back; and otherwise, taking the current to-be-processed transaction and a new to-be-processed transaction received in the preset time period as target processing transactions, sorting according to the timestamps, sequentially processing the transactions, obtaining a transaction processing result, feeding back the transaction processing result to the distributor, and feeding back the result by the distributor according to the transaction processing result. By implementing the method and the device, the problem of low processing efficiency caused by transaction processing by using a traditional lock mechanism in the prior art can be solved.

The invention relates to recombinant IL2 variant polypeptides suitable to generate IL2 prodrugs and the prodrugs comprising said variant polypeptides that may be activated at a target site.

This invention discloses a gene editing method and application for *Trichoderma reesei* based on a ribonucleoprotein complex. It aims to overcome the problems of low editing efficiency, easy generation of heterozygotes, and risk of exogenous DNA integration in *Trichoderma reesei* using plasmid-based CRISPR / Cas9 systems. This invention combines a dual-site cleavage strategy guided by double sgRNAs with direct RNP delivery. The method involves: designing two guide RNAs spaced 50-700 bp apart for the target gene, pre-assembling them with Cas9 protein in vitro to form an active RNP complex; delivering this complex along with exogenous donor DNA to *Trichoderma reesei* protoplasts. The exogenous donor DNA contains a left homologous arm, an editing sequence, and a right homologous arm, wherein the left and right homologous arms are homologous to the genomic sequences outside the dual cleavage sites on the target gene determined by the double sgRNAs, respectively; upon entering the cell, the RNP complex introduces dual-site cleavage at the target site, achieving precise editing under the guidance of the exogenous donor DNA.

The invention relates to modified apolipoprotein with a targeting body. The targeting body may for example be an antibody or antigen binding fragment that allows targeting of e.g. a specific cell, tissue or organ. The modified apolipoprotein can be used as a carrier for a payload as such or when incorporated in a lipid nanoparticle. The modified apolipoprotein finds use in the treatment or prevention of diseases, or targeting a pay load to a specific target site.

A deployment system for accurate placement of localization tags within biological tissue is disclosed. The system comprises a catheter hub with sheath, a stylet, and a loader. The catheter hub provides an interface for system components, while the flexible sheath allows navigation to target sites. The stylet, operable in multiple positions, guides the sheath and assists in tag deployment. The loader houses the localization tag and acts as a safety spacer during deployment. The system is compatible with endoscopes and various imaging modalities, offering improved accuracy and efficiency over traditional wire localization techniques. The localization tags may be passive or active, with potential for advanced functionalities such as biosensing or drug delivery. This minimally invasive system finds applications in tumor marking, lymph node localization, and targeted therapy delivery across multiple medical specialties.

The utility model discloses a lifting auxiliary mounting device for an evacuation platform of a subway tunnel. The lifting auxiliary mounting device comprises a frame, a lifting feeding mechanism, a first feeding mechanism, a second feeding mechanism and a guide mechanism. The lifting feeding mechanism is arranged on the upper end face of the frame and located on one side of the second conveying channel, the first feeding mechanism is arranged on the first conveying channel, and the second feeding mechanism is arranged on the second conveying channel. After the device arrives at a target site, the first feeding mechanism conveys the materials to the second feeding mechanism, the second feeding mechanism conveys the materials to the lifting feeding mechanism, and the lifting feeding mechanism conveys the materials to a mounting target site. The device can also work cooperatively with various feeding devices, and full-automatic seamless feeding is achieved. The device is high in automation degree, and workers can convey materials in a tunnel conveniently; meanwhile, the device is highly suitable for the narrow environment of the tunnel, the installation and transportation efficiency of the tunnel evacuation platform steel beam and the platform plate is improved, and the material conveying difficulty is reduced.

The invention discloses a method and device for determining an access point deployment scheme, equipment, a medium and a product, and belongs to the technical field of communication. The method comprises the following steps: acquiring a house type image and an input vector of a target place; an initial deployment scheme is obtained by inputting the house type image and the input vector into a pre-trained scheme prediction model, and the initial deployment scheme comprises a plurality of deployment areas in the target place and AP parameter information corresponding to the deployment areas; determining a search space corresponding to each deployment area based on the AP parameter information, and generating a plurality of candidate deployment schemes by performing neighborhood search in the search space; and determining a target deployment scheme according to the signal quality estimated values of the plurality of candidate deployment schemes. Through the mode, the network signal quality in the target place can be improved to the greatest extent, and the problem of non-uniform signal coverage is avoided, so that the internet surfing experience of the terminal equipment is improved.

This disclosure provides a system and method for non-invasively delivering ultrasound (US) pulses to a target site in a subject. The target site is either a blood vessel or blood-flowing tissue. By delivering US pulses to the target site, a therapeutic process in the body is facilitated. This therapeutic process is typically associated with the production of nitric oxide molecules induced by ultrasound irradiation. This disclosure provides a solution combining a US transducer with one or more sensors. The sensors can detect parameters indicating whether the US transducer is properly coupled and positioned to the subject's body site, enabling safe application of US pulses, or whether the subject and / or target area are in a state to tolerate ultrasound irradiation.

The invention provides a device for treating at least one of rhinitis, congestion, and / or rhinorrhea to thereby reduce or eliminate symptoms associated therewith, including, but not limited to, coughing, sneezing, nasal or throat irritation and itching, and difficulty sleeping. The device includes a shaft, a retractable and expandable end effector, and handle, that, as a whole, provide a high level of precise control and feedback to an operator during a procedure. The shaft includes an electrode array provided along a length thereof configured to deliver energy to specific target sites within the nasal passage and nasal cavity in conjunction with neuromodulation provided by the end effector.

Embodiments of the present invention provide devices and methods for treating various target sites, such as vascular abnormalities. For example, a medical device according to one embodiment includes at least one layer of a fabric of braided strands having proximal and distal ends and a central axis extending therebetween. The medical device has an expanded configuration a generally frustroconical shaped portion at each end. The medical device is configured to be constrained to a reduced configuration for delivery through a diagnostic catheter and to at least partially return, when unconstrained, towards the expanded configuration.

The embodiment of the invention provides a satellite navigation reference station site selection method and device and electronic equipment. The method comprises the following steps: acquiring a selected area, and determining an area to be built according to topographic information of the selected area, an electric power communication guarantee area and position information of built stations; and performing grid division according to the position information of the selected area, determining a plurality of to-be-built sites, and determining a plurality of candidate to-be-built sites and scores of the candidate to-be-built sites according to the to-be-built site area and the plurality of to-be-built sites. According to the scores of the multiple candidate sites to be built, at least one target site to be built is screened out from the multiple candidate sites to be built, and the target site to be built is the target satellite navigation base station site to be built. According to the invention, the intelligent level of site selection and the site selection efficiency are improved.

Techniques are described for performing a phase correction for magnetic resonance imaging. The techniques include: for each slice of a target site: using a channel compression algorithm to determine each virtual channel of the slice using a channel compression matrix; determining a main virtual channel of the slice from each virtual channel; using phase correction data of the main virtual channel of the slice of the target site to perform phase correction on multi-segment image data of each virtual channel of the slice of the target site. This results in a reduction in phase errors in multi-segment MR image data.

The invention provides a construction method and application of a humanized MECP2 gene mouse model, and relates to the field of gene engineering. The model animal with the humanized hMECP2 gene is successfully prepared, the humanized hMECP2 protein can be normally expressed in the body of the model, and the model can be used for MECP2 gene function research and screening and evaluation of human MECP2 targeted drugs and therapies. The animal model prepared by the invention can be used for rapidly establishing more different MECP2 mutation humanized disease mouse models, and is applied to drug screening, drug effect research, related nervous system disease and tumor treatment and the like aiming at human MECP2 target sites, so that the research and development process of new drugs is accelerated, the time and the cost are saved, and the drug development risk is reduced. And a powerful tool is provided for researching the functions of the MECP2 protein and screening drugs.

A skin treatment device is disclosed, which has a head capable of contacting a target site of a user, the head having an electrically driven cutter unit capable of cutting hair when in operation, and an action mechanism configured to apply a specific action to the target site of the user contacted by the cutter unit based on power supplied from a power source. The action mechanism includes, for example, a heating element that generates heat by flowing a direct current and / or a pair of electrodes that generate an electric stimulus.

Disclosed are methods of delivering a therapeutic to a target site of a subject comprising administering a lipid capsule to a target site of a subject, wherein the lipid capsule comprises a therapeutic agent; and applying an alternating electric field, at a frequency for a period of time, to the target site of the subject, wherein the alternating electric field releases the therapeutic from lipid capsule at the target site of the subject. Disclosed are methods of increasing target site specific release of a therapeutic agent in a subject comprising administering a lipid capsule to a target site of a subject, wherein the lipid capsule comprises a therapeutic agent; and applying an alternating electric field, at a frequency for a period of time, to the target site of the subject, wherein the alternating electric field releases the therapeutic agent from the lipid capsule at the target site of the subject, thereby increasing the target site specific release of the therapeutic agent. Disclosed are methods of treating comprise administering a lipid capsule to a target site of a subject in need thereof, wherein the lipid capsule comprises a therapeutic agent; and applying an alternating electric field, at a frequency for a period of time, to the target site of the subject in need thereof, wherein the alternating electric field releases the therapeutic agent from the lipid capsule at the target site of the subject in need thereof. Disclosed are methods of killing a cell comprising administering a lipid capsule to a target site, wherein the lipid capsule comprises a therapeutic agent; and applying an alternating electric field for a period of time, to the target site, wherein the alternating electric field releases the therapeutic agent from the lipid capsule at the target site, wherein the target site comprises a cell, wherein the therapeutic kills the cell.

CHAMP1 haploinsufficiency syndrome is caused by deficiencies in normal CHAMP1 protein expression. Herein are described methods of identifying target site blocking (TSB) oligonucleotides that hybridize to CHAMP1 mRNA and thereby block the binding of inhibitory non-coding RNAs, such as miRNAs. Such TSB oligonucleotides are therefore useful in treating CHAMP1 haploinsufficiency syndrome.