The invention discloses an oblique launching method for a large-section rectangular jacking pipe. The oblique launching method includes the steps that S1, an enclosure structure is constructed on the periphery of a jacking pipe working well; S2, the pipe jacking working well is excavated, and an inclined steel ring is pre-buried at the position of a tunnel portal in the jacking direction; S3, the enclosure structure at the position of a jacking pipe starting portal is chiseled off; S4, according to the jacking direction, guide rail base concrete is constructed in the pipe jacking working well, and a guide rail is installed on the guide rail base concrete; S5, a wedge-shaped extension steel ring is installed, a rib plate is installed at the exposed end of the wedge-shaped extension steel ring, and a cavity formed by the enclosure structure, the inclined steel ring, the wedge-shaped extension steel ring and the rib plate is filled a low-strength machinable filler; S6, a wedge-shaped rear backrest, a jack support, a propelling jack and a rectangular pipe jacking machine are hoisted; S7, linkage jacking iron is placed in the pipe jacking working well and connected with the propelling jack, and retaining devices are installed on the two sides of the jack support on the inclined face side of the wedge-shaped rear backrest; and S8, the rectangular pipe jacking machine is pushed to move forwards for construction through the propelling jack, and the oblique launching of the rectangular jacking pipe is completed.