The invention relates to a simulation system of loading and unloading operation processes in pressurized water reactor (PWR) nuclear power plants. The system comprises an LED (light emitting diode) display screen, a touch screen, an operation control table consisting of a component part consisting of a button, a switch, an operating rod, an indicator lamp and an alarm, an information communication and processing device consisting of a programmable logic controller PLC (programmable logic controller) and a PC graphic workstation, a display device consisting of a scene display and a camera, and an industrial personal computer. The simulation system of the loading and unloading operation processes is designed in strict accordance with functions of real loading and unloading machines, is featured with rich simulated objects, reliable simulation data and strong reality, simulates various common abnormal states or failure states, allows interactive operation, clears faults and has a component showing function; the touch screen has an interface control function; the system simplifies layout of an operation table, expands subsequent functions, effectively trains loading and unloading operators and is widely applied to nuclear power stations and related analogue simulation systems.