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1691results about How to "Promote enrichment" patented technology

Methyl aldehyde adsorbing substance and preparation method thereof

The invention relates to a formaldehyde adsorbent and a preparation method. The formaldehyde adsorbent consists of a basis material, a high molecular organic amine polymer and a polylol polymer, wherein the high molecular organic amine polymer and the polylol polymer account for 1 to 50 percent of the formaldehyde adsorbent, and the balance being the basis material. The preparation method for the formaldehyde adsorbent comprises steps of preparing formaldehyde reagent, preprocessing the basis material, solidifying and forming, and the like. When the formaldehyde adsorbent adsorbs formaldehyde, formaldehyde gas can quickly enrich on the surface of the formaldehyde adsorbent, and carries out chemical reaction to generate substances harmless to human body, so as to achieve the effect of uninterruptedly and thoroughly removing the formaldehyde; the adopted raw materials are nontoxic and harmless; the preparation technology has simple and easily controlled process; and the prepared formaldehyde adsorbent is safe and environment-friendly, and has no secondary pollution.
Owner:718TH RES INST OF CHINA SHIPBUILDING INDAL CORP

Preparation method of loading iron based metal organic skeleton out phase Fenton catalyst and application thereof

The invention relates to a preparation method of a loading iron based metal organic skeleton out-phase Fenton catalyst and an application thereof. The preparation method comprises the following steps of by taking MIL-100 (Fe) as a basal body, loading a ferrous component through a hydrothermal method so as to obtain the loading iron based metal organic skeleton out-phase Fenton catalyst, namely Fell@ MIL-100 (Fe). The catalyst is used for degrading an organic pollutant in waste water by using an out-phase Fenton catalyst system. Compared with the prior art, the loading catalyst prepared by the invention fully utilizes the advantages of MIL-100 (Fe) and a ferrous component in an out-phase Fenton reaction, so that the loading catalyst has high porosity, large specific surface area, and is stable in a water phase, catalytic activity sites are uniformly dispersed, the capacity is controllable and the like, meanwhile, the mutual circulation action of the Fe<2+> component in a carrier and a Fe<3+> in the basal body are utilized to further strengthen the Fenton reaction activity, the catalyst is suitable for removing refractory organics in waste water by catalytic oxidation of out-phase Fenton, the operation of the technology is simple, the cost is low, the preparation method is an efficient and energy-saving new technology, and the catalyst has the far-reaching application prospect and wide social and economic benefits.
Owner:TONGJI UNIV

Lipidosome-polymer drug-loaded nanoparticle and preparation method and application thereof

The invention provides a lipidosome-polymer drug-loaded nanoparticle and a preparation method and application thereof. The lipidosome-polymer drug-loaded nanoparticle comprises a three-layer structure, wherein the innermost layer is the drug-loaded nanoparticles formed by taking an amphiphilic cationic polymer as a carrier-coated chemotherapeutic drug; the intermediate layer is a platelet inhibitor layer adsorbed onto the surface of the drug-loaded nanoparticles; and the outermost layer is a lipid bilayer connected with tumor microenvironment responsiveness polypeptides. The lipidosome-polymer drug-loaded nanoparticle disclosed by the invention is capable of specifically targeting tumor tissues, has tumor microenvironment responsiveness, and can achieve the effects of improving tumor vascular permeability without influencing functions of blood vessels at normal tissue or cell parts, enhancing permeability and retention of the drug-loaded nanoparticles to tumor cells, enhancing the EPR effect, improving enrichment of the drug-loaded nanoparticles at tumor location and realizing high tumor killing efficiency.
Owner:THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA

Method and device for producing methane by using dry anaerobic digestion for urban sludge and organic matter

The invention belongs to the field of reclamation of solid wastes, in particular relating to a method and a device for producing methane by using a dry anaerobic digestion for urban sludge and an organic matter. The device comprises a reaction chamber and a double-layer helix ribbon type agitator and is provided with a feed inlet and outlet, a sample port, a temperature-setting controller, a methane metering device, a stirring control device and others devices. The method comprises the following steps: dewatering sludge is placed into a fermentation tank for inoculation and seal, the revolving speed at start-up stage is 5-15r / min and daily stirring time is 12h, the revolving speed at acid-producing stage is 10-20r / min, intermittent operation is carried out; the daily stirring time is more than or equal to 8h and less than or equal to 16, and starting and stopping frequency for the motor is required to be increased; temperature control is performed at acid-producing stage and methane-producing stage and material temperature is controlled to be 35+ / -1 DEG C; and after finishing the fermentation, one fourth to one third of biogas residues are left for being used as inoculum for the next batch of fermented materials and the rest of residues are discharged. The invention can be applied to reclamation treatment of the urban sludge and can obviously save equipment investment and land occupation compared with the wet fermentation.
Owner:TONGJI UNIV

Method for producing DHA by Schizochytrium in high-density culture through fermentation

The invention discloses a method for producing DHA by Schizochytrium in high-density culture through fermentation, relates to a preparation method of DHA, and provides a method for producing DHA by using a microbial fermentation method, which replaces fish oil to extract omega-3 polyunsaturated fatty acids. The method comprises the following steps of: inoculating strains in a shake flask according to the ratio of strains to a culture medium of 1: (5-10) for culturing until the dry weight of cells in fermentation liquor is 10-12g / L; inoculating the strains in the shake flask in a 1000L seed fermenter according to the inoculum size of 5-10%, culturing until the dry weight of the cells in the fermentation liquor is 20-24g / L; inoculating the strains in the 1000L seed fermenter in a 8000L seed fermenter according to the inoculum size of 5-10%, and culturing for 120-130 hours, wherein the dry weight of the cells in the fermentation liquor is 120-150g / L, and the DHA content is up to 26-30g / L. In the invention, through optimizing the culture medium and optimizing the culture conditions and by adopting a conventional fermentation method, the production rate of the DHA is at least 3 times more than the reported production rate. The production costs of the strains (the Schizochytrium), the culture medium and the culture condition are low, the yield is high, and the method is applicable to the industrial production of the DHA.
Owner:XIAMEN HUISON BIOTECH

Composite soldering material for soldering titanium alloy and ceramic or ceramic matrix composition material and method for soldering by using same

The invention discloses a composite soldering material for soldering a titanium alloy and a ceramic or a ceramic matrix composition material and a method for soldering by using the same, and solves the problems that a welding joint obtained by soldering the titanium alloy and the ceramic or the ceramic matrix composition material through the conventional soldering material is easy to crack and has low strength, and the introduction of a ceramic phase in a method of introducing the ceramic phase into the soldering material causes reduction of wettability of a connecting layer for a base metal. The composite soldering material consists of Cu, Ni and a reinforced phase, wherein the reinforced phase is TiB2 powder or SiC powder. The method comprises the following steps of: performing ball milling on the Cu, Ni and TiB2 or SiC powder, uniformly mixing, and coating to-be-welded surfaces of the titanium alloy and the ceramic to obtain to-be-welded parts; and putting the to-be-welded parts into a vacuum brazing furnace for vacuum brazing treatment. In the soldering process, the composite soldering material has good wettability for the ceramic and ceramic materials, and the obtained welding joint has no crack, the shear strength between 16 and 45MPa, and good mechanical properties.
Owner:HARBIN INST OF TECH

Pyridine degradable bacteria, complex bacterial agent thereof, preparation and use

The invention discloses a pyridine-degrading bacterium as well as a composite bacterial agent, a preparation method and uses thereof. The newly-separated Rhodococcus pyridinovora KT-J002 CGMCC No.2789 and Cellulomonas sp KT-J007 CGMCC No.2788 not only can effectually degrade the high concentration pyridine, but also has tolerance or degradation ability for toxic substances such as benzene, phenol, dimethylbenzene, quinoline, cyanide and the like; the composite bacterial agent composed of Rhodococcus pyridinovora KT-J002 CGMCC No.2789, Cellulomonas sp KT-J007 CGMCC No.2788, Paracoccus d enitrificans W12 CGMCC No.1673, Micrococcus luteus ATCC 49442 and Arthrobacter crystallopoietes ATCC 15481 is used for environmental improvement, can effectually degrade the pyridine and is particularly suitable for the biological treatment of coking waste water.
Owner:SINOBIOWAY BIO AGRI GRP CO LTD

Method and device for treating organic waste gas by combining photocatalysis and microorganisms and application thereof

The invention provides a method for treating organic waste gas by combining photocatalysis and microorganisms. Simultaneously, the invention also discloses a device of the method for treating the organic waste gas by combining the photocatalysis and the microorganisms and application thereof. The method for treating the organic waste gas by combining the photocatalysis and the microorganisms comprises the steps of physical dust removal, photocatalyst catalytic oxidation, microorganism purification, and the like, and can effectively eliminate total suspended particulate matters in the organic waste gas and volatile organic compounds in waste gas. The device of the method for treating the organic waste gas by combining the photocatalysis and the microorganisms is applied to treating industrial organic waste gas, and is particularly applicable to treating the organic waste gas in various industrial organic waste gas emission workshops.
Owner:深圳市中拓天达环保科技有限公司

Method for preparing malts with high malt aroma and beer thereof

ActiveCN103773642AImprove foam stabilityRaise the level of freshnessMalt preparationBiotechnologyMaillard reaction
The invention relates to the field of malting and in particular relates to a method for preparing malts with high malt aroma and beer thereof. The method mainly comprises the following steps: selecting wheat, raw material pretreatment, steeping, sprouting, green malt drying, kilning and removing roots. According to the steeping and sprouting process, the sprouting uniformity is improved, lots of amino acids and reducing sugars are generated under the optimum water activity conditions, the degree of a Maillard reaction is controlled through the drying and gradient temperature rise kilning process, specific malt aroma components are generated, and due to sensory evaluation, the malt has pure and strong aroma, is clean and coordinative and does not have burnt taste and other odors. The method is used for improving the content of malt aroma substances in the malt, the defects that the malt prepared in the prior art is not obvious in aroma and partial specific malts have obvious burnt taste except certain malt aroma are overcome, the technical problem that the malt is aromatic but easily burnt is effectively solved, pure and strong malt aroma is presented, the malt can be used for preparing high-malt aroma wort or high-malt aroma beer, and the typical flavor characteristics of the malt aroma of the beer are reflected.
Owner:TSINGTAO BREWERY

Multiple combined repairing system and method for arsenious organism in soil

The invention belongs to the technical field of environmental protection, and particularly relates to a multiple combined repairing system and a multiple combined repairing method for arsenious organism in the soil. The repairing system consists of a microwave repairing system, a chemical oxidation system and a plant repairing system; the microwave repairing system is used for heating the to-be-repaired soil, collecting gas generated by volatile organisms and injecting oxidant into the soil so as to enable the arsenious organism to have oxidation reaction under the microwave catalysis, the trivalent arsenic is oxidized into pentavalent arsenic, then the pentavalent arsenic is enriched by planting hyperaccumulator, pteris vittata, and the microwave repairing system and the plant repairing system are alternately operated. The microwave repairing method is combined with the chemical oxidation method to intermittently and alternately repair the soil in combination with plant repair, so that the arsenious organism in the soil can be effectively and further treated.
Owner:NORTH CHINA ELECTRIC POWER UNIV (BAODING)

ph and oxidation-reduction dual-sensitive layer cross-linking nanoparticle as well as preparation method and application thereof

The invention relates to a pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle as well as a preparation method and an application thereof. A hydrophilic layer which at least contains PCB (Polycarboxylate Betaine) or PEG (Polyethylene Glycol) is positioned on the surface of the nanoparticle, a hydrophobic nuclei which at least contains a pH-sensitive polymer unit is positioned in the nanoparticle, and an S-S (Disulfide Bond) cross-linking layer which is formed through cross-linking reaction between PDS (Polymethacrylamide Ehtylpyridine Disulfide) units is positioned between the hydrophilic layer and the hydrophobic nuclei. A tumor targeted group can be modified on the hydrophilic layer positioned on the surface of the pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle, and the gathering of the nanoparticle on a tumor tissue and the endocytosis of the nanoparticle on the tumor cell are accelerated through the specific targeted effect of the nanoparticle on a tumor cell. The pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle disclosed by the invention has the advantages of good biocompatibility and low toxicity. According to the pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle, a cross-linked structure is dissociated under the action of glutathione inside the tumor cell, so that the release of a medicine is promoted. The preparation method disclosed by the invention is simple, convenient, good in stability and conveniently operated and popularized.
Owner:天津渤化讯创科技有限公司

Biomatrix Hydrogels and Methods of Use Thereof

This invention is directed to aragonite and calcite hydrogel biomatrices, optionally seeded with precursor cells and uses thereof in tissue engineering, regeneration and repair, including in inducing or enhancing bone formation, cartilage formation or a combination thereof in a subject, and kits related thereto.
Owner:CARTIHEAL 2009

On-line analysis system for automatic pretreatment by adopting ultra high performance liquid chromatography/mass spectrum

The invention discloses an on-line analysis system for automatic pretreatment by adopting an ultra-high performance liquid chromatography / mass spectrum. The on-line analysis system has an automatic pretreatment mode and a post-column compensation mode, and comprises four chromatography pumps, two high-pressure switch valves, an automatic sample injector, an on-line diluter, an extraction column, an on-line filter, two sample rings, a miniature mixer, a chromatographic column, a tee joint, a mass spectrometry detector and the like. On-line dilution, extraction, desorption, separation, detection and post-column compensation analysis can be carried out on a target analyte in a liquid sample by combination of an on-line dilution / extraction / desorption device, a stigma focusing device, a post-column compensation device and an ultra high performance liquid chromatography / mass spectrum device, the overall analysis process is automatically controlled, and is high in accuracy and precision, and the on-line analysis system can be effectively applied to the analysis detection on trace organic compounds in a complicated liquid sample or a liquid extracting solution.
Owner:SHIMADZU (CHINA) CO LTD

Targeted photothermal black phosphorus nano-preparation as well as preparation method and application thereof

The invention provides a targeted photothermal black phosphorus nano-preparation, which is prepared from a black phosphorus nano-slice, polyethylene glycol absorbed on the surface of the black phosphorus nano-slice by means of electrostatic attraction, and folic acid connected to the polyethylene glycol by means of an amide bond, wherein one end of the polyethylene glycol is amino, and the other end of the polyethylene glycol is imino; nitrogen atom of the imino and carbonyl carbon atom of the folic acid are connected with each other so as to form the amide bond; the folic acid is exposed at the outermost layer of the nano-preparation. The targeted photothermal black phosphorus nano-preparation is high in stability, good in target recognition ability and excellent in light-heat property, is capable of effectively killing cancer cells, and can be used for performing targeted photothermal treatment on cancers at the cellular level. The invention also provides a preparation method and application of the targeted photothermal black phosphorus nano-preparation.
Owner:SHENZHEN UNIV

Method for enhancing aerobiotic ammonia oxidizing bacterium gathering through N-acylated homoserine lactones

The invention belongs to the technical field of sewage treatment and relates to a method for enhancing aerobiotic ammonia oxidizing bacterium (AOB) gathering through N-acylated homoserine lactone (AHLs) compounds. The method includes the specific steps that AHLs signal molecules with the specific variety and the specific concentration are added to a reactor containing AOB activated sludge, under the condition that a sufficient nitrogen source and oxygen are provided, a quorum-sensing system is enhanced, aerobiotic ammonia oxidizing bacterium gathering growth is promoted, and biological membranes or granular sludge is obtained. According to the method, the AOB physiology is adjusted and controlled on the aspect of the signal molecules, AOB gathering growth is enhanced, rapid and efficient enrichment of AOB is achieved, and the AOB is fixed in a qualified sense, so that losses are reduced, and time needed for AOB enrichment is shortened. A new thought is provided for rapid AOB enrichment through the method, the method is expected to be used for the biological nitrogen removal process, and important significance is provided for efficient and stable operation of the ammonia-nitrogen wastewater biological treatment process.
Owner:BEIJING NORMAL UNIVERSITY

Preparation method of microfluidic monolithic column chip and application of chip in raman detection

The invention provides a preparation method of a microfluidic monolithic column chip and an application of the chip in raman detection. The method comprises the steps that a polydimethylsiloxane (PDMS) microfluidic chip is prepared; a porous monolithic column solution is prepared; a monomer, a crosslinking agent, a pore-forming agent and a photoinitiator are subjected to ultrasonic mixing; nitrogen is supplied for deoxygenization; and finally the monolithic column solution is put in an ice bath for preservation. The solution is injected into a microfluidic chip pipeline, sealed and subjected to ultraviolet exposure, methanol washing is adopted for removing the pore-forming agent and the unreacted monomer, deionized water is used for washing sufficiently, a silver microsphere solution is injected into the microfluidic chip, ultra-sensitive raman real-time detection of a to-be-detected sample is achieved by utilizing silver microsphere enrichment and a surface raman enhancement effect, and a detection limit of the method can reach 10-12M. The method is convenient, flexible, low in cost, low in energy consumption, and convenient to popularize, and is widely applied to the fields of serum marker detection, gas marker detection, environmental monitoring, food safety and the like.
Owner:SHANGHAI JIAO TONG UNIV

Subcritical hydrothermal treatment-based efficient recycling treatment process for sludge

The invention relates to a subcritical hydrothermal treatment-based efficient recycling treatment process for sludge. According to the treatment process, sludge with the solid content of 10 to 25 percent of a sewage treatment plant is placed into a hydrothermal reaction kettle for 5 to 30 minutes at the subcritical high temperature of 200 to 300 DEG C and under the high pressure of 1.6 to 8.6 MPa, so that intracellular substances in sludge are fully dissolved, solid organic matters are fully dissolved and hydrolyzed and are partially decomposed; the release of bound water and surface water in the sludge facilitates improvement on the dehydration performance of the sludge. The sludge which is subjected to hydrothermal modification is dehydrated to enable the solid content of the dehydrated sludge to be not higher than 60 percent, and then aerobic composting stabilizing treatment is performed. The filtrate which is rich in dissolved organic matters and is obtained by dehydrating the sludge enters a high-speed anaerobic digestion system for fully recovering methane. According to the technology, the hygienization, the recycling and the stabilization of the sludge are realized effectively; the subcritical / supercritical reaction speed is high, the subsequent efficient anaerobic digestion hydraulic retention time is short, and the solid residues generated after hydrothermal modification dehydration are few, so that large-scale urban sludge treatment capacity can be realized by adopting small-capacity reactors in a hydrothermal link, an anaerobic link and an aerobic link of the treatment process.
Owner:TONGJI UNIV

Nutritious sprouted glutinous coarse rice flour and preparation process thereof

The invention discloses nutritious sprouted glutinous coarse rice flour and a preparation process thereof. The nutritious sprouted glutinous coarse rice flour comprises 50-80% of sprouted glutinous coarse rice flour, 10-30% of buckwheat flour, 5-10% of bean flour and 5-10% of sesame flour; and the preparation process comprises the following steps of: sprouting at a selected proper temperature, spraying a mixed solution containing CaCl2 and monosodium glutamate during the sprouting operation to promote the enrichment of gamma-amino butyric acid (GABA) in sprouting, and finally, obtaining the nutritious sprouted glutinous coarse rice flour with GABA content of up to 20-40 mg / 100g, thereby supplementing the nutritious ingredients such as GABA and the like in the rice flour. The nutritious sprouted glutinous coarse rice flour plays roles in reducing blood pressure, improving brain function, calming nerves and promoting long-term memory; after being baked and cured, the nutritious sproutedglutinous coarse rice flour product has intense rice incense and good pasting performance and anti-caking performance. Due to the adoption of the nutritious sprouted glutinous coarse rice flour, the varieties and designs of the glutinous rice flour are enriched, and the utilization rate and the additional value of the glutinous coarse resources are increased.
Owner:ANHUI SCI & TECH UNIV +1

Polyurethane elastomer with lateral chain containing fluoroalkyl and preparation method thereof

The invention discloses a polyurethane elastomer with a lateral chain containing fluoroalkyl and a preparation method thereof. The method comprises the following steps: (1) adding RFOH, halogenated oxygen heterocyclic ring compound, catalyst and polar solvent according to a ratio, reacting under the protection of nitrogen and stirring, reducing pressure and distilling to obtain the monomer of fluoroalkyl-substituted oxygen heterocyclic ring compound; (2) adding solvent, cyclic ether compound, initiator and catalyst according to a ratio, dropwise adding the monomer of fluoroalkyl-substituted oxygen heterocyclic ring compound, reacting under the protection of nitrogen and stirring, washing, standing for layering followed by reducing pressure and distilling to obtain polyether polyalcohol resin with a lateral chain containing fluoroalkyl; and (3) taking the polyether polyalcohol resin with the lateral chain containing fluoroalkyl, diisocyanate and catalyst according to a ratio, reacting under the protection of nitrogen to obtain a prepolymer, rapidly pouring the prepolymer into a preheating mould for curing after chain extension reaction and degassing to obtain the polyurethane elastomer with the lateral chain containing fluoroalkyl. The invention can be used for manufacturing high performance coating and elastomer.
Owner:SHANGHAI INST OF TECH

Cationic liposome and preparation method thereof

The invention discloses a cationic liposome, comprising cationic lipid, neutral phospholipid, polyethylene glycol derivatived phospholipid and mannose or mannan oligosaccharide, wherein a shell-shaped phospholipid bilayer is formed by phospholipid molecules in the the cationic lipid, the neutral phospholipid and the polyethylene glycol derivatived phospholipid; and mannose- or mannan oligosaccharide- modified polyethylene glycol derivatived phospholipid is formed by connecting the mannose or the mannan oligosaccharide with one end of the polyethylene glycol derivatived phospholipid. By adding the mannose- or mannan oligosaccharide- modified polyethylene glycol derivatived phospholipid, targeting property and enrichment in lymph glands of antigen-presenting cells are increased; the cationic liposome has an immunologic enhancement effect; and the immune efficacy of liposome-encapsulated vaccines can be increased. The invention also provides a preparation method of the cationic liposome.
Owner:SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI

Refueling method for fuel assemblies of reactor core of PWR (pressurized water reactor) nuclear power plant

The invention is applicable to the field of fuel management on reactor cores of pressurized water reactors, and provides a refueling method for fuel assemblies of a reactor core of a PWR (pressurized water reactor) nuclear power plant. The method comprises: classifying the fuel assemblies of the reactor core into three enrichment areas according to different enrichment degrees; in an initial cycle, respectively adding 8, 12 and 16 burnable poison rods into the fuel assemblies, and according to a cycle length of 18 months, placing the fuel assemblies with high enrichment degree outside the reactor core, and placing the fuel assemblies with low enrichment degree in the reactor core, wherein the enrichment degrees of the fuel assemblies of an initial reactor core are respectively 3.9%, 3.1% and 2.0%; and in subsequent cycles, starting from a second cycle, and rapidly transitioning the subsequent cycles to an equilibrium cycle according to an enrichment degree of 4.45%, wherein a mode of 18-month refueling is adopted, and the fuel assemblies of 1 / 2-1 / 3 of the reactor core are replaced every time; meanwhile, placing the new fuel assemblies in the reactor core, and placing the fuel assemblies which are burned outside the reactor core. By using the refueling method provided by the invention, the cycle period is extended, the fuel consumption is improved, and the purpose of completely low neutron leak loading is achieved in the subsequent cycles.
Owner:GUANGDONG NUCLEAR POWER JOINT VENTURE

Comprehensive washing remediation method and system for heavy metal contaminated soil

The invention discloses a comprehensive washing remediation method for heavy metal contaminated soil. The comprehensive washing remediation method comprises the following steps: ploughing and smashing soil, applying acid and alkaline washing agent solid materials, then drawing water when ploughing, washing and dissolving heavy metal out of the soil, and transferring the heavy metal into washing water; guiding the washing water into a sedimentation tank, adding a coagulant, and removing the heavy metal in the washing water through coagulation and sedimentation; draining the washing water into a microorganism and biochar purifying tank, utilizing biochar bags to absorb the heavy metal, and at the same time, enriching the heavy metal through microorganisms on biochar surfaces; and collecting used biochar bags, adding a dilute acid solution into the biochar bags, stirring, and separating the heavy metal absorbed to the biochar surfaces. The invention further discloses a corresponding comprehensive washing remediation system. The technical scheme of the invention greatly increases the absorption rate of the heavy metal, avoids heavy metal secondary pollution, is simple in technical process, is high in automation degree and is low in cost.
Owner:HUAZHONG UNIV OF SCI & TECH

Method for preparing functional gradient hydrogel for bone-cartilage repair

The invention discloses a method for preparing functional gradient hydrogel for bone-cartilage repair and belongs to the technical field of biological materials. Two parts of double-bond biomacromolecule pre-polymerization liquid with the same mass fraction are prepared firstly, then the pre-polymerization liquid is prepared into upper-layer cartilage repair pre-polymerization liquid containing repair factor nanoparticles and lower-layer subchondral bone repair pre-polymerization liquid containing calcium phosphorus nanoparticles, and based on suspension principle and optical polymerization reaction, the functional gradient hydrogel is formed through sedimentation and diffusion of nanoparticles, wherein the function of the functional gradient hydrogel changes along with the change of compositions and structure. The prepared bionic hydrogel has high biodegradability and biocompatibility, loaded growth factors are high in efficiency and slow release performance, cartilage and subchondral bone repair can be induced, bidirectional regeneration of bone-cartilage is achieved, and repair of cartilago articularis injuries is achieved.
Owner:SOUTHWEST JIAOTONG UNIV

Drug target virtual screening method based on interactive fingerprints and machine learning

ActiveCN106446607AFully consider the specificityAvoid the pitfalls of underfittingBiostatisticsSpecial data processing applicationsProtein targetBinding site
The invention relates to a drug target virtual screening method based on interactive fingerprints and machine learning. According to the method, based on traditional molecular docking, the interactive fingerprints of known active and non-active micromolecules and target protein are trained through machine learning to obtain a screening model of targets, and the obtained model is used for virtual screening. The specific targets are specifically trained, the specificity of each kind of targets is fully considered, and the defect of insufficient fitting of a traditional scoring function is avoided; interaction energy of each micromolecule and each residue in a binding pocket is calculated, so that effective binding sites or binding modes can be found; non-linear fitting is carried out through machine learning, and compared with linear fitting, the correlation or coupling effect between all the interaction energy can be better processed; by means of the method, enrichment of active molecules is better promoted.
Owner:EAST CHINA NORMAL UNIV

Immobilized nitrobacteria enrichment culture method and device in sewage treatment process

The invention discloses an immobilized nitrobacteria enrichment culture method and device in a sewage treatment process. A sequencing-batch biomembrane activated sludge process is utilized to perform enrichment culture on nitrobacteria: dewatered sludge is inoculated in an immobilized nitrobacteria culture device, and an enrichment culture solution is added; and in the nitrobacteria enrichment culture process, the biomembrane ammonia nitrogen load is gradually enhanced, and the pH value is controlled. The enrichment culture solution is formed by mixing NH4HCO3 and pretreated municipal sewage, the ammonia nitrogen concentrations are respectively 100, 300, 500, 700 and 1000 mg/L, and the COD (chemical oxygen demand) concentration is 30-60 mg/L. By controlling the immobilized nitrobacteria culture device, the DO in the reaction mixture is 2-6 mg/L, the pH value is 6.5-8.0, the biofilm-formation acclimatization culture temperature is 10-14 DEG C, and the enrichment purification culture temperature is 15-25 DEG C. The device can be used for culturing nitrobacteria at low temperature, and the nitrobacteria content is up to 40-45%. The immobilized nitrobacteria have high low-temperature nitration resistance, and can treat the wastewater of which the ammonia nitrogen concentration is up to 1000 mg/L, so that the ammonia nitrogen in the wastewater is lowered to 1.0 mg/L or below.
Owner:BEIJING GENERAL MUNICIPAL ENG DESIGN & RES INST

Affinity chromatography fixed phase of immobilization metal and its preparation method

InactiveCN101288844AImprove selective enrichment effectReduce non-specific adsorptionOther chemical processesSynthesis methodsMicrosphere
The invention relates to a separation and purification technique, in particular to an affinity chromatography stationary phase of immobilized metal and a preparation method thereof. The structure of the stationary phase is shown in the drawing; wherein, the particle size of GMAPolymer micro-sphere is 10nm-50um; the GMAPolymer micro-sphere is poly-methacrylic acid glycidyl esters micro-sphere. By carrying out amination and phosphoric esterification, a synthesis method of the high-performance poly-methacrylic acid glycidyl ester-group novel affinity chromatography stationary phase is gained and used for the research in phosphorylation proteomics and highly-selective separation, enrichment and purification of phosphopeptide by the chelation with zirconium ions and iron ions; meanwhile, compared with the traditional stationary phase, the affinity chromatography stationary phase reduces the nonspecific adsorption on the non-phosphopeptide.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI

Method for converting active sludge into autotrophic denitrified sludge based on mixed type continuous flow reactor

The invention belongs to the treatment field of waste water, and provides a method for converting active sludge into autotrophic denitrified sludge based on a mixed type continuous flow reactor. The method which is used for converting the common active sludge into the autotrophic denitrified sludge by the continuous flow reactor specifically comprises two stages. The first stage comprises the steps of: converting anaerobic or anoxic sludge into a nitrosation status by the condition which controls the organic matter concentration (COD (chemical oxygen demand) is less than 20mg / L), the water dissolved oxygen concentration (1-0.5mg / L), and the inflowing ammonia nitrogen concentration (50-450mg / L), and restraining the growth of the other microorganisms step by step by the running condition and the washing characteristic of the continuous flow reactor. When the cumulative percentage of the nitrite is more than 60%, the second stage is started. The second stage comprises the step of: promoting the nitrosation status to be converted into the autotrophic denitrification status by the condition which improves the ammonia nitrogen concentration (450-550mg / L), reduces the dissolved oxygen (0.5mg / L), and keeps a certain PH value (7.5-8.0) to form a system which is coupled nitrosified microorganism to anammox microorganism. The practice proves that the system can stably run for a long term. After entering into the practical running stage of the waste water treatment, the method leads the ammonia nitrogen removing rate and the total nitrogen removing rate to be respectively more than 80% and 70% by the reaction which is remained only by the natural reoxygenation or a small quantity of aeration without aeration.
Owner:SUN YAT SEN UNIV

Method for dissolving out rare-earth by treating waste neodymium-iron-boron materials

The invention discloses a method for dissolving out rare-earth by treating waste neodymium-iron-boron materials. The method comprises the following steps of: crushing materials into powder, wetting and dispersing by using an electrolyte solution, and carrying out size mixing; then controlling electric potential between +400 mV and +800 mV by adding an oxidizing agent, and controlling pH between 2.5 and 4.5 by adding inorganic acid; leaching for 30-80 minutes under the condition that the temperature is 50-90 DEG C; after the leaching is completed, carrying out solid-liquid separation and filter residue washing; purifying, enriching and separating the rare-earth from leach liquor with solid leaching residues separated, wherein filter residues are taken as raw materials used for producing iron products after being washed. The method disclosed by the invention improves the extraction rate of the rare-earth and is convenient for extracting the rare-earth subsequently by adopting multiple methods by adopting subacid oxidizing leaching, reduces the usage amount of acid, alkali and other chemicals, does not adopt the high-temperature oxidation method and reduces the energy consumption.
Owner:CENT SOUTH UNIV
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