611 results about "Chelation" patented technology

The invention discloses a mine water fluorine removal agent and a preparation method and application thereof, and belongs to the technical field of wastewater treatment.The preparation method of the fluorine removal agent comprises the following steps that aluminum salt, calcium salt, magnesium salt and ferric salt are added into water to be stirred, then a chelating agent, a hydroxy carboxylic acid compound and a dispersing agent are added, the mixture is heated to 40-60 DEG C to be stirred and dispersed, and heat preservation is conducted. The preparation method gets rid of the constraint of traditional calcium salt, introduces the chelating agent, the hydroxy carboxylic acid compound and the dispersing agent on the basis of controlling the compatibility of the materials and the synthesis reaction process, and utilizes the excellent fluorine ion adsorption performance and flocculation settling performance of the aluminum-calcium-magnesium-iron-based quaternary metal material to improve the fluorine ion adsorption performance of the aluminum-calcium-magnesium-iron-based quaternary metal material. Quaternary metals are assembled into a long-chain porous structure through chelation, the specific surface area and the pore volume are further increased, the contact area with fluorine ions in mine water is increased, and the porous structure adsorbs complexing groups to achieve the purposes of rapid coordination, strong adsorption, precise chelation, flocculating settling and efficient removal of fluoride in mine water.

The invention belongs to the technical field of inter-cooling water treatment, and relates to a system and method for cooperatively treating inter-cooling water through multi-stage bypasses. Comprising a gradient filtering unit, a modified adsorption unit and a composite adsorption unit which are sequentially connected, a bottom outlet of the gradient filtering unit is connected with a bottom inlet of the modified adsorption unit; a top outlet of the modified adsorption unit is connected with a top inlet of the composite adsorption unit; the gradient filtering unit sequentially comprises a manganese sand layer and a quartz sand layer from top to bottom; the modified adsorption unit is filled with a coal gangue modified straw biochar material; the composite adsorption unit is internally filled with a microcapsule-embedded calcium alginate-vinasse biochar composite material. According to the invention, three-stage cooperative treatment of iron suspended matter interception, sulfate radical adsorption and iron ion chelation is realized, and low-cost, green and sustainable indirect cooling water deep purification is realized by using the solid waste-based functional material.

The invention provides a low-molecular soluble chelating collector as well as a preparation method and application thereof, and belongs to the technical field of mineral processing. According to the collecting agent, low-molecular-weight ethylene glycol terephthalate serves as a precursor, and isosorbide is introduced for a copolymerization reaction; glutamic acid is introduced as a branched chain unit, and the branching degree and reaction active site density of the molecular structure are remarkably improved by utilizing the polyfunctional group characteristic of glutamic acid. A rigid ring structure and an ether bond of the isosorbide endow the medicament with good water solubility and dispersity, and invalid curling of a macromolecular chain is avoided; the introduction of glutamic acid branched chains greatly increases the number of hydroxyl groups and amino groups capable of reacting with carbon disulfide, so that each molecule carries more xanthate groups, and the adsorption stability and coverage density of the molecule on the surface of arsenopyrite are enhanced. By means of the structure, xanthate functional groups are fully exposed, multi-tooth chelation is easily conducted on the xanthate functional groups and iron and arsenic ions on the surface of arsenopyrite, a strong hydrophobic surface layer is formed, and therefore the collecting selectivity is remarkably improved.

The application discloses a light-controlled nitric oxide releasing hollow single-atom nanoscale enzyme, a preparation method and application, and belongs to the technical field of biomedical materials. In the application, spherical silica nanoparticles are used as a template, and a structure of copper ion-polydopamine coated silica nanoparticles is formed on the surface of the silica nanoparticles through self-polymerization of dopamine and chelation of copper ions, and the spherical structure is maintained with the support of the silica nanoparticles. The copper ion-polydopamine coated silica nanoparticles are pyrolyzed to obtain a copper-based single-atom nanoscale enzyme with a carbon skeleton, and a hollow spherical single-atom nanoscale enzyme is obtained after etching. Nitric oxide donor molecules are loaded into the hollow of the hollow spherical single-atom nanoscale enzyme to obtain the light-controlled nitric oxide releasing hollow single-atom nanoscale enzyme. The application can realize the synergistic treatment effect of photothermal therapy, nitric oxide gas therapy and biological catalytic therapy, is used for efficiently removing bacteria and biofilms at an infected wound site, and effectively promotes the healing of the bacteria-infected wound.

The invention provides a novel macrocyclic compound, a gadolinium chelate thereof, a method for preparing the compound and application of the compound as a magnetic resonance contrast agent. The compound has pertinence on magnetic resonance detection of liver focal lesions and can be used for liver specific imaging.

The invention discloses a preparation process of a rare earth precipitation resistant electrophoretic coating for an automobile body. The preparation process comprises the following steps: S1, preparing a stable solution; s2, preparing a rare earth chelating solution; adding lanthanum lactate into the stable solution for multiple times, and adding ammonium ceric sulfate for multiple times after the lanthanum lactate is completely dissolved; s3, preparing a resin base solution; s4, preparing mixed slurry; s5, adding a solvent and an auxiliary agent; a five-membered ring chelate with thermodynamic stability is formed by carboxyl, hydroxyl and rare earth elements in sodium citrate, rare earth ions can be tightly wrapped through strong coordination bonds, namely, empty orbits of the rare earth ions and lone pair electrons of a chelating agent form coordination bonds, so that the rare earth ions cannot be dissociated in a system, and the rare earth ions are prevented from being dissociated in the system. And a path of generating hydroxide precipitates by free rare earth ions is thoroughly blocked, so that rare earth elements are effectively ensured to be uniformly distributed in the electrophoretic paint, and the surface of a raw material treated by a subsequent electrophoresis process is more uniform.

The invention specifically discloses a preparation method of a FeZn diatomic nano enzyme with adjacent double metal sites. The product is of a planar sheet structure, chitosan serves as a chelating support, and the product is prepared through in-situ doping of bimetallic precursors of Fe and Zn in a competitive coordination and high-temperature pyrolysis mode. The preparation method comprises the following steps: taking chitosan as a sacrificial template, taking ferric nitrate and zinc chloride as precursors, and carrying out in-situ conversion on the metal precursors into bimetallic atom sites by virtue of a high-temperature pyrolysis means, so as to prepare the FeZn diatomic nano-enzyme. FeZn diatoms exist in an adjacent state, the peroxidase-like activity of the FeZn diatoms is larger than that of monatomic Fe nano-enzyme and monatomic Zn nano-enzyme, the FeZn diatoms have excellent storage stability and high-temperature-resistant catalytic stability, and the preparation method has the advantages of being high in expandability, simple in process, green in raw material, stable in diatom structure and the like.

The invention relates to a water-based ball-milled passivated aluminum paste and a preparation method and application thereof, and the preparation method comprises the following steps: carrying out ball milling on aluminum powder, a surface modifier, a hydrophilic solvent and an inorganic passivator until the target particle size of the aluminum powder is reached, and obtaining preliminarily passivated aluminum paste; carrying out suction filtration on the primarily passivated aluminum paste, uniformly stirring and mixing, adding an organic passivator, continuously stirring to carry out a passivation reaction, adding an auxiliary agent, and continuously stirring to obtain aluminum paste; wherein the organic passivator is a combination of a micromolecular organic passivator and a macromolecular organic passivator. According to the method, the in-situ passivation technology is adopted, the aluminum sheet is passivated in the extension process, the influence of dissolution and auxiliaries on the aluminum sheet is small, a more compact protective film is formed through the synergistic effect of the inorganic passivator and the organic passivator and through the oxidation film layer, chelation and precipitation reaction, corrosion of aluminum powder is greatly inhibited, and the service life of the aluminum sheet is prolonged. And the water-based passivated aluminum paste and a water-based resin system maintain good compatibility, and can show good glossiness.

An aqueous pharmaceutical composition including compound having the formula of tetragadolinium [4,10-bis(carboxylatomethyl)-7-{-3,6,12,15-tetraoxo-16-[4,7,10-tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecan-1-yl]-9,9-bis({[({2-[4,7,10-tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecan-1-yl]propanoyl}amino)acetyl]amino}methyl)-4,7,11,14-tetraazaheptadecan-2-yl}-1,4,7,10-tetraazacyclododecan-1-yl]acetate wherein the stereochemistry at the chiral carbon of the four alanine substituents is selected from the group consisting of RRRR, SSSS, RSSS, RRSS, and RRRS stereoisomers, and racemic and diastereomeric mixtures of any thereof, or a tautomer, a hydrate, a solvate, or a salt thereof, or a mixture of same is described. The compounds may be used as an MRI contrast imaging agent.

The invention relates to the technical field of polypeptides, in particular to an enzyme-mimetic polypeptide, hydrogel, a preparation method and application, the enzyme-mimetic polypeptide selects a peptide fragment I and a peptide fragment II with biocompatibility and degradability as basic sequences, and the peptide fragment I and the peptide fragment II form a beta folding unit, so that the stability of a polypeptide structure can be enhanced; then, the peptide chain is driven to be self-assembled to form a regular nanofiber structure; according to the invention, the characteristic that the biomimetic polypeptide and metal ions are subjected to a complex reaction to form a chelate is utilized, the transparent and stable hydrogel can be rapidly formed without adding a gelatinizing agent, and TEM, SEM and rheological characterization are carried out on the hydrogel to find that the hydrogel containing the biomimetic polypeptide has a porous nanofiber network structure, so that the biomimetic polypeptide can be used for preparing the hydrogel. Meanwhile, the biomimetic polypeptide hydrogel has the same flexibility as natural tissues, and the characteristics indicate that the biomimetic polypeptide hydrogel is expected to have wide application prospects in the aspects of biomimetic materials, antibiosis, cell culture, drug carriers and the like.

The invention discloses an insect antibacterial peptide nutrient solution as well as a preparation method and application thereof, and belongs to the technical field of biology. Insect protein (fly maggot powder / hermetia illucens) and plant fiber (bran) are subjected to enzymolysis and then subjected to a pH gradient chelation process (5.0-7.0-8.5), metal ions (Fe < 2 + > / Mn < 2 + > / Zn < 2 + >) are added in stages for chelation, the chelation degree is larger than or equal to 91.4%, lentinan and alginate oligosaccharide are added for synergistic interaction, and finally the insect antibacterial peptide nutrient solution is obtained. Experiments prove that after the insect antibacterial peptide nutrient solution prepared by the invention is used for carrying out root irrigation treatment on plants, tomato yellow leaf curl virus or tomato spotted wilt virus can be remarkably prevented and treated, and the insect antibacterial peptide nutrient solution has high efficiency and persistence and conforms to the development direction of green plant protection.

The invention relates to the technical field of high polymer materials, in particular to an anti-aging thread gluing material and a preparation process thereof. Comprising the following steps: preparation of aluminum-doped zinc oxide, tannic acid modified aluminum-doped zinc oxide, ferulic acid modified nylon fiber and modified nylon master batch preparation of the thread gluing. According to the invention, groups of tannic acid and aluminum ions and zinc ions of aluminum-doped zinc oxide are driven by heat energy of a reflux reaction to simultaneously generate chelation-dehydration condensation to form a five-membered ring chelate, so that a compact coating layer is formed on the surface, and the coating layer is simple in component and has very stable chemical bonds; the ultraviolet light stability of aluminum-doped zinc oxide is enhanced, the layer can generate hydrogen bond / pi-pi interaction with nylon amido bonds, the interface bonding strength is improved, the particle size is kept at the level of no filter pressure fluctuation in the spinning process, and the volume resistivity of nylon fibers is reduced.

The specific embodiment of the invention provides an anti-rust coating and a coating, the anti-rust coating comprises a water-based rust conversion agent and a water-based epoxy coating, the water-based rust conversion agent comprises a water-based acrylic emulsion and ammonium polyacrylate salt, the pH value of the water-based rust conversion agent is 6-8, Fe < 3 + > is converted into a stable complex in situ through a carboxyl chelation reaction, and the stable complex is added into the water-based epoxy coating. The water-based rust conversion agent and the epoxy coating have the advantages that the water-based rust conversion agent is added into the water-based epoxy coating, the continuous acid etching risk of a matrix is avoided, the water-based epoxy coating comprises polydopamine grafted and coated silicon dioxide, micropores can be reduced by the coating, permeation of water, oxygen and chloride ions can be inhibited, hydrolytic stripping and secondary corrosion can be prevented, and the water-based rust conversion agent and the epoxy coating have good compatibility; the formed coating is excellent in interlayer adhesive force and compact and firm in film layer, and the long-acting protection requirement in a severe corrosion environment can be met when the anti-rust coating is used for coating corrosion prevention of a steel member.

The invention relates to the technical field of fertilizers, in particular to a preparation method of a chelated medium element preparation for a synergistic liquid fertilizer. The technical problems that a chelating agent is high in cost, poor in stability and low in bioavailability are solved. The efficient chelating agent is prepared by efficiently extracting or converting a polysaccharide-polyphenol compound and a small peptide mixture with unique chelating performance from specific agricultural or industrial wastes and mixing the polysaccharide-polyphenol compound and the small peptide mixture. Then, a chelating-wrapping dual-stabilization technology is adopted, specifically, a high-efficiency chelating agent and medium element ions are subjected to a chelating effect, and then modified chitosan is added to wrap the chelate, so that nutrient loss is reduced, and nutrient elements are released more evenly. The chelated medium element preparation remarkably improves the stability and effectiveness of nutrient elements through the synergistic effect of double stabilization mechanisms.

The invention relates to the technical field of agriculture, and discloses a synergistic technology for repairing soil and promoting plant stem cells by using modified amino active groups. Comprising the following steps: modifying an amino acid compound, namely modifying active groups in amino acid and fulvic acid, so that the active groups have a synergistic effect with cellulase, hemicellulase, urease, phosphatase, chitinase, beta-glucanase, superoxide dismutase, peroxidase and catalase; through the strong chelation of the modified amino active groups and heavy metal ions in soil, the bio-availability and mobility of heavy metals can be effectively reduced, for example, the chelation removal rate of cadmium, lead and other heavy metals can reach 40% or above, the heavy metal contaminated soil is repaired, the soil structure is improved, the content of organic matters in the soil is increased, and the pH value of the soil is adjusted; the acidified or alkalized soil is gradually restored to a pH range suitable for plant growth, and the water and fertilizer retention capability of the soil is improved.

The present application relates to a kind of composite phosphorus-free scale inhibitor and its preparation method, including 800-1200 parts by weight of desalted water, 1-3 parts by weight of modified lignin sulfonate, 2-4 parts by weight of calcium magnesium acetate, 0.5-1.5 parts by weight of azole, 400-600 parts by weight of soluble inorganic zinc salt and 50-150 parts by weight of copolymer A.The composite phosphorus-free scale inhibitor provided by the present application is clear and transparent concentrate, after the above concentrate is added to circulating water, the effective ingredient in it can form soluble chelate with Ca 2+ , Mg 2+ Forming, increase the saturation solubility of ion, hinder micro-fouling lattice formation, distort crystal growth, so that microcrystalline will not accumulate into scale, and can make old scale loose, gradually shed old scale;At the same time, the special corrosion inhibitor and other corrosion inhibitor produce synergistic effect, which can effectively control the pitting of stainless steel, achieve the purpose of preventing scale, and fundamentally reduce the efficiency of corrosion and scale inhibition.

The invention provides an efficient boiler scale and corrosion inhibition composite agent and a preparation method thereof, and belongs to the technical field of water treatment agents. The sulfonated polycarboxylic acid copolymer is introduced, crystal nucleus formation is inhibited through chelation of carboxylic acid groups of the sulfonated polycarboxylic acid copolymer, the dispersing capacity and hard water tolerance are improved through sulfonic acid groups, normal growth of microcrystals can be adsorbed and interfered through regulation and control of isopropanol on molecular weight, and loose scale bodies easy to remove are promoted to be formed; the polyether grafted copolymer is used as an efficient dispersing agent, the main chain of the polyether grafted copolymer is responsible for adsorbing and anchoring generated tiny scale bodies, and extended polyether long side chains of the polyether grafted copolymer form a steric hindrance shielding layer to wrap particles and suspend stably, so that the scale bodies are prevented from gathering and growing up; the two components cooperate to form a scale inhibition defense line, and cooperate with auxiliary agents such as the compound amine and the deoxidant in the system to construct a comprehensive protection network, so that long-period stable operation of the boiler system is guaranteed.

The invention relates to the field of photoelectrochemistry, in particular to a photo-anode based on phosphonic acid chelation and photoelectrochemistry activation and a preparation method of the photo-anode. The invention aims to provide a deep-energy-level defect dynamic passivation method based on phosphonic acid chelation and photoelectrochemical synergistic activation, which comprises the following steps: introducing 1-hydroxyethylidene-1, 1-diphosphonic acid (HEDP) molecules (ZISH) on the surface of a zinc-indium-sulfur (ZIS) photo-anode in a low-temperature water bath manner, and carrying out chelation reaction on the molecules and Zn sites on the surface in a photoelectrochemical activation manner, so as to obtain the deep-energy-level defect dynamic passivation method based on phosphonic acid chelation and photoelectrochemical synergistic activation. And a stable Zn-O-P coordination structure is formed. Under the action of photoelectric bias, the structure can reconstruct a Zn-S frame in situ, adjust the coordination number of Zn and convert a deep trap into a shallow energy level state (ZISA), so that interface recombination is effectively inhibited while a high hole injection rate is maintained.

The invention discloses a polydopamine-tea polyphenol coated copper manganese oxide composite nano-enzyme as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. According to the invention, a DA-Cu (II)-EGCG (epigallocatechin gallate) complex is formed by virtue of chelation of main components of dopamine and tea polyphenol, namely epigallocatechin gallate, and copper ions; potassium permanganate is introduced for oxidative polymerization to obtain the polydopamine-tea polyphenol / copper manganese oxide organic-inorganic hybrid nano composite material, the nano composite material is monodisperse nano particles, the average particle size is about 80 nm, the nano composite material shows excellent nano enzyme catalytic activity, active oxygen free radicals can be effectively removed, and the nano composite material can be used for preparing nano-enzyme. The material has good photo-thermal conversion performance under near-infrared light, and shows excellent photo-thermal and photodynamic synergistic antibacterial effects. The preparation method disclosed by the invention is simple, mild, environment-friendly, low in cost and convenient for batch production.

The invention provides an etching solution, application thereof and an etching method of an aluminum-based metal laminated film, and particularly relates to the technical field of etching solutions. The etching liquid is prepared from the following components in percentage by weight: 3 to 10 percent of metal oxidizing agent, 55 to 85 percent of phosphoric acid, 5 to 15 percent of organic acid, 0.2 to 1.8 percent of organic acid ammonium, 0.1 to 1.2 percent of nitric acid imidazole ionic liquid, 0.15 to 0.8 percent of amino acid based ionic liquid, 0.05 to 1.2 percent of modified beta-cyclodextrin, 0.08 to 1 percent of polyalcohol ether compound and the balance of water. The etching liquid has the advantages of low line width loss, excellent etching profile, high cleanliness, good compatibility and long service life, a buffer system, a chelation mechanism and a volatilization inhibition function are effectively cooperated, the service life of the liquid medicine is greatly prolonged, excellent chemical stability and aging resistance are fully reflected, high-compatibility etching is realized, and the corrosion resistance of the liquid medicine is improved. And the comprehensive performance advantages of high precision, low defect and long service life are also realized.

The invention discloses a preparation method and application of high-sensitivity and high-stability time-resolved fluorescent microspheres, and relates to the technical field of immunochromatography. The preparation method comprises the following steps: (1) preparing high-stability high-carboxyl-density polystyrene microspheres; (2) preparing a high-stability europium ion chelate; and (3) preparing the high-stability fluorescent microspheres. Through a strategy of combining functional monomer copolymerization and surface covalent labeling, the fluorescent microspheres which are connected through strong covalent bonds from inside to outside and are high in stability and carboxyl density are constructed; obvious differential advantages and innovativeness are shown in the aspects of chemical stability, anti-leakage capability of fluorescent markers and surface functional group density. A time-resolved fluorescent microsphere test strip developed based on the microspheres has the advantages of good stability, high detection sensitivity and the like, and can realize rapid detection and analysis of a substance to be detected.

The invention belongs to the field of field remediation functional materials, and particularly relates to a preparation method and application of a chelating iron agent for remediation of organic contaminated soil. The preparation method comprises the following steps: firstly, preparing a chelating agent aqueous solution, adding ferrite under a continuous stirring condition to carry out chelation reaction, then adding organic acid to carry out stabilization treatment, finally adding an activating auxiliary agent fulvic acid, uniformly mixing, and adjusting the pH value of the solution to a required value to obtain the chelating iron agent. The chelating iron agent can be used for activating an oxidizing agent during in-situ / ex-situ remediation of an organic polluted site, and has the advantages that the chelating iron agent is environment-friendly, the ferrous ion stability is good, the contact reaction with the oxidizing agent is mild and controllable, iron precipitates are not easy to form, and the growth and metabolic activity of indigenous organisms are stimulated.

The invention belongs to the technical field of petrochemical anticorrosion, and provides a multifunctional water-soluble corrosion inhibitor for an oil refining device and a preparation method of the multifunctional water-soluble corrosion inhibitor, and the corrosion inhibitor is a functionalized grafted copolymer obtained by a ring-opening reaction of a succinimide ring on a polysuccinimide intermediate and a plurality of amino-containing compounds; the amino-containing compound at least comprises gemini imidazoline quaternary ammonium salt with a corrosion inhibition function; a polyaspartic acid chain segment precursor with scale inhibition and dispersion functions; the organic amine compound has targeted chelating and pH buffering functions and contains sulfonic acid groups and carboxyl groups; according to the invention, double-anchored gemini imidazoline quaternary ammonium salt is taken as a corrosion inhibition core, and a polysuccinimide ring-opening grafting process is combined, so that chain segments with corrosion inhibition, scale inhibition, targeted buffering and temperature-sensitive self-repairing functions are covalently integrated into a same polymer main chain, and multi-functional efficient protection of a single agent in an oil refining device water phase system is realized.

The invention belongs to the field of biomedical materials, and particularly relates to a coagulation-promoting embolism microsphere and a preparation method thereof. The sericin-based embolism microspheres are creatively prepared, and the sericin membrane layer on the surface of the microspheres can prevent the risk that a catheter is solidified during an operation due to thrombin burst release during the operation. On the other hand, sericin in the microspheres has excellent water absorption swelling property and lubricity, and is beneficial to embolism and prevention of reflux; moreover, sericin molecules contain a large amount of hydroxyl and carboxyl, so that the chelation of blood coagulation factor calcium ions is greatly improved. In addition, thrombin factors are loaded into the microspheres, calcium ions are chelated on the surfaces of the microspheres, the microspheres are endowed with rapid embolism capacity through the superimposed effect, blood flow blocking of target blood vessels can be effectively accelerated, and reflux is prevented. The prepared procoagulant embolism microspheres are suitable for being applied to treatment of vascular-rich tumors of the brain and can effectively prevent mistaken closure of many complex functional blood vessels of the brain due to reflux.

The application discloses an automatic control method for oxidation flocculation parameters in mancozeb wastewater treatment, and belongs to the technical field of industrial wastewater treatment and automatic control. In view of the problem that the existing process relies on manual experience and the oxidation and flocculation stages are improperly connected, the multifunctional modified material containing dithiocarbamate salt groups, quinone groups and pre-complexed manganese and zinc ions is prepared first; the material and hydrogen peroxide are synchronously added in the acid oxidation stage, and the control system monitors the redox potential change rate in real time; when the redox potential reaches the preset threshold value and the characteristic change point with the first derivative of zero or the change from positive to negative appears and is maintained for the preset maintenance time, the system is automatically adjusted to be alkaline, the modified material triggers the net capture and chelation crosslinking reaction, and finally solid-liquid separation is carried out; the polymer skeleton is protected from indiscriminate attack of free radicals, the problem of drug antagonism is overcome, and the stable and up-to-standard effluent quality is realized.

The invention relates to the technical field of synthesis of inorganic porous materials, in particular to a hierarchical pore ZSM-5 molecular sieve and a synthesis method thereof.The method comprises the steps that an aqueous solution of a guiding agent serves as a solvent, an aluminum source is dissolved in the solvent to form a mixed solution, a chelating agent and a silicon source are added into the mixed solution, the chelating agent and the silicon source react to form a chelate, seed crystals are added, and the hierarchical pore ZSM-5 molecular sieve is obtained. According to the present invention, the guiding agent can be adsorbed on the surface of the seed crystal to obtain the mixed gel, and the hierarchical pore ZSM-5 molecular sieve is obtained after the hydrothermal reaction of the mixed gel, and the synthesized hierarchical pore ZSM-5 molecular sieve has the typical MFI type micropore channel, the micropore-mesopore-macropore combined hierarchical pore structure and the ultra-large particle size of 10-35 [mu] m, the method has a huge application prospect in the chemical fields of macromolecular catalysis, adsorption and the like.

The invention relates to a radionuclide labeled trimer probe 68Ga-TRAP-(FAPI) 3 targeting FAP and a preparation method thereof, Trap is used as a trivalent chelating platform, and three FAPI targeting units are covalently connected by clicking a chemical linking arm to form a trimer structure; the invention further relates to application of the 68Ga-TRAP-(FAPI) 3 probe in preparation of imaging agents or therapeutic drugs for diagnosing FAP positive diseases, experiments prove that the trimer probe is good in affinity and high in stability, and in cell experiments and animal experiments, the uptake rate of FAP positive cells is kept at a high level within 240 minutes; preclinical and preliminary clinical applications show that the tumor detection rate of the < 68 > Ga-TRAP-FAPI 3 in various cancer models is superior to that of < 18 > F-FDG, and compared with < 68 > Ga-FAPI-04, the < 68 > Ga-TRAP-FAPI 3 is clearer to display focuses (particularly tiny metastases), higher in uptake intensity and particularly outstanding in delayed imaging, and the < 68 > Ga-TRAP-FAPI 3 can be used for preparing a medicine for treating cancer. And a novel drug candidate with better performance is provided for precise diagnosis and staging of tumors and subsequent radionuclide targeted therapy.

The invention discloses a lipid compound for delivering a therapeutic agent as well as a preparation method and application of the lipid compound, and particularly discloses a compound shown in a formula I or pharmaceutically acceptable salt, stereoisomer, tautomer, solvate, chelate, non-covalent complex or precursor of the compound, the ionizable lipid compound can effectively deliver nucleic acid molecules, small molecule compounds and other drugs, and through comparison, the lipid nanoparticles are good in particle size distribution and high in encapsulation efficiency, the delivery effect can be obviously better than that of contrast lipid nanoparticles, and the requirement of in-vivo delivery can be met. (I)

The invention discloses cysteine mediated Hf / Cu bimetal synergistic self-assembled nano-particles as well as a preparation method and application of the cysteine mediated Hf / Cu bimetal synergistic self-assembled nano-particles. According to the method, cysteine is used as a multifunctional ligand, carboxyl and sulfydryl of cysteine are in bridge connection with metal through coordination, ligand chelation and assembly guiding effects are synchronously exerted, bimetallic ions are induced to be cooperatively self-assembled in an alkaline system (pH is 9-10), and metal cysteine self-assembled nanoparticles with uniform structures are formed through in-situ nucleation and multistage aggregation. According to the method, the ligand function and the bimetallic synergistic effect are accurately matched, the synthesis process is mild (room temperature), the operation is simple and convenient, and the product is excellent in dispersity and stability. Meanwhile, a close coordination structure constructed by cysteine provides a key channel for energy / electron transfer from sensitizing metal to Cu under X-ray irradiation, and lays a structural foundation for subsequent catalytic effect enhancement.

The invention belongs to the technical field of medicine manufacturing, and particularly relates to a compound preparation containing faropenem sodium as well as a preparation method and application of the compound preparation. According to the invention, the production prescription is optimized, the stability of the medicine can be effectively improved, the unpleasant smell of the medicine is covered, and the medication compliance of children is obviously improved. The epigallocatechin-aluminum complex can serve as a free radical scavenger in a preparation system, oxygen free radicals are effectively captured and neutralized, and the influence of oxidative stress on the medicine is reduced; moreover, the existence of aluminum ions not only enhances the stability of EGCG, but also reduces the drug degradation reaction under the catalysis of the ions through chelation with trace metal ions (such as iron, copper and the like) in the preparation. In addition, aluminum ions can also directly form a stable complex with faropenem sodium, so that the chemical stability of the faropenem sodium is further improved.