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214 results about "Aromatic moiety" patented technology

The four drugs that contain aromatic moiety are fluconazole, celecoxib, stanozolol and tazobactum. The structures are shown in the picture attached, please hview the full answer.

Thyroid receptor ligands and method II

New thyroid receptor ligands are provided which have general formula (I) in which: n is an integer from 0 to 4; R1 is halogen, trifluoromethyl, or alkyl of 1 to 6 carbons or cycloalkyl of 3 to 7 carbons; R2 and R3 are the same or different and are hydrogen, halogen, alkyl of 1 to 4 carbons or cycloalkyl of 3 to 5 carbons, at least one of R2 and R3 being other than hydrogen; R4 is a carboxylic acid amide (CONR′R″) or an acylsulphonamide (CONHSO2R′) derivative, or a pharmaceutically acceptable salt thereof, and all stereoisomers thereof; or when n is equal to or greater than one, R4 may be a heteroaromatic moiety which may be substituted or unsubstituted, or an amine (NR′R″). R5 is hydrogen or an acyl (such as acetyl or benzoyl) or other group capable of bioconversion to generate the free phenol structure (wherein R5=H). In addition, a method is provided for preventing, inhibiting or treating a disease associated with metabolism dysfunction or which is dependent upon the expression of a T3 regulated gene, wherein a compound as described above is administered in a therapeutically effective amount. Examples of such diseases associated with metabolism dysfunction or are dependent upon the expression of a T3 regulated gene include obesity, hypercholesterolemia, atherosclerosis, cardiac arrhythmias, depression, osteoporosis, hypothyroidism, goiter, thyroid cancer as well as glaucoma, congestive heart failure and skin disorders.
Owner:KARO BIO AB

Modulation of anxiety through blockade of anandamide hydrolysis

Fatty acid amide hydrolase inhibitors of the Formula:
are provided wherein X is NH, CH2, O, or S; Q is O or S; Z is O or N; R is an aromatic moiety selected from the group consisting of substituted or unsubstituted aryl; substituted or unsubstituted biphenylyl, substituted or unsubstituted naphthyl, and substituted or unsubstituted phenyl; substituted or unsubstituted terphenylyl; substituted or unsubstituted cycloalkyl, heteroaryl, or alkyl; and R1 and R2 are independently selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, and substituted or unsubstituted phenyl, substituted or unsubstituted biphenylyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl; with the proviso that if Z is O, one of R1 and R2 is absent, and that if Z is N, optionally R1 and R2 may optionally be taken together to form a substituted or unsubstituted N-heterocycle or substituted or unsubstituted heteroaryl with the N atom to which they are each attached. Pharmaceutical compositions comprising the compounds of Formula I and methods of using them to inhibit FAAH and/or treat appetite disorders, glaucoma, pain, insomnia, and neurological and psychological disorders including anxiety disorders, epilepsy, and depression are provided.
Owner:UNIV DEGLI STUDI DI PARMA +1

Polycarbonate-polyorganosiloxane copolymer and method for producing same

Provided is a polycarbonate-polyorganosiloxane copolymer having high impact resistance and excellent transparency, in particular, a high total light transmittance and a small haze, and a method of producing thereof. Specifically, provided is a polycarbonate-polyorganosiloxane copolymer, containing a main chain having a repeating unit represented by the following general formula (I) and a constituent unit represented by the following general formula (II), in which: n in the general formula (II) is 25 to 50; and the copolymer satisfies the following conditions (a) and (b): (a) a molded article having a thickness of 2 mm made of the copolymer has a total light transmittance measured based on ISO 13468 of 88% or more and a haze measured based on ISO 14782 of 0.7% or less; and (b) a molded article having a thickness of 3 mm made of the copolymer has a total light transmittance measured based on ISO 13468 of 88% or more and a haze measured based on ISO 14782 of 1.0% or less.(In the formulae, R1 and R2 each independently represent a halogen atom, an alkyl group or an alkoxy group, X represents a single bond, an alkylene group, an alkylidene group, a cycloalkylene group, a cycloalkylidene group, —S—, —SO—, —SO2—, —O— or —CO—, and a and b each independently represent an integer of 0 to 4. R3 to R6 each independently represent a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group or an aryl group, Y represents a single bond, or an organic residue containing an aliphatic or aromatic moiety, and n represents an average repetition number.)
Owner:IDEMITSU KOSAN CO LTD
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