This invention relates to the field of
biotechnology, specifically disclosing a novel polypeptide, recombinant XIX type humanized collagen, and their applications. This invention provides a novel polypeptide with good
cell adhesion activity and the ability to promote
cell proliferation. The
amino acid sequence of the polypeptide comprises n repeating units; each repeating unit comprises any one of the following (1)-(3)
amino acid sequences or their variants: (1) the
amino acid sequence shown in SEQ ID NO.1; (2) an amino acid sequence having at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99%
sequence identity with the amino acid sequence shown in SEQ ID NO.1; (3) a variant sequence obtained by mutating one or more amino acid residues of the amino acid sequence shown in SEQ ID NO.1; wherein n ≥ 1 and is an integer. The polypeptide of this invention can be used in various fields such as promoting
skin barrier repair,
wound healing, and epidermal renewal.