The invention is directed to a biodegradable,
thermoplastic multiblock copolymer, to a process for preparing a biodegradable,
thermoplastic multiblock copolymer, to the use of a biodegradable
thermoplastic multiblock copolymer, to a composition for the delivery of at least one pharmacologically
active compound to a host, and a
medical device comprising a biodegradable, thermoplastic multiblock
copolymer. The biodegradable, thermoplastic multiblock copolymers of the invention comprise at least one
prepolymer (A) segment and at least one hydrolysable amorphous
prepolymer (B) segment, wherein the segments are linked by a multifunctional chain
extender, wherein the at least one
prepolymer (A) segment comprises: a) one or more hydrolysable linkages, b) a water-soluble polyoxazoline-based
polymer, and c) reaction products of one or more cyclic monomers and / or one or more non-cyclic monomers, wherein the water-soluble polyoxazoline-based
polymer is a
polymer containing a repeating unit of structure ā[N(COR1)CH2CH2]nā where R1 is independently selected for each repeating unit from an
alkyl group and n is 3-100, and wherein the multiblock
copolymer is amorphous.